Jump to main content
Jump to site search

Issue 15, 1992
Previous Article Next Article

Unusual ring expansion observed during the Dakin–West reaction of tetrahydroisoquinoline-1-carboxylic acids using trifluoroacetic anhydride: an expedient synthesis of 3-benzazepine derivatives bearing a trifluoromethyl group

Abstract

The reaction of N-acyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids with trifluoroacetic anhydride proceeds through mesoionic 1,3-oxazol-5-one intermediates followed by ring expansion to form 2-trifluoromethyltetrahydro-3-benzazepinone derivatives in good yields.

Back to tab navigation

Article type: Paper
DOI: 10.1039/C39920001076
J. Chem. Soc., Chem. Commun., 1992, 1076-1077

  •   Request permissions

    Unusual ring expansion observed during the Dakin–West reaction of tetrahydroisoquinoline-1-carboxylic acids using trifluoroacetic anhydride: an expedient synthesis of 3-benzazepine derivatives bearing a trifluoromethyl group

    M. Kawase, J. Chem. Soc., Chem. Commun., 1992, 1076
    DOI: 10.1039/C39920001076

Search articles by author

Spotlight

Advertisements