Issue 10, 2020

CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review

Abstract

The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anti-tuberculosis, anti-diabetic, and anti-Alzheimer drugs. The importance of click chemistry is due to its ‘quicker’ methodology that has the capability to create complex and efficient drugs with high yield and purity from simple and cheap starting materials. The activity of different triazolyl compounds was compiled considering MIC, IC50, and EC50 values against different species of microbes. In addition to this, the anti-oxidant property of triazolyl compounds have also been reviewed and discussed.

Graphical abstract: CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review

Article information

Article type
Review Article
Submitted
14 Nov 2019
Accepted
08 Jan 2020
First published
04 Feb 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 5610-5635

CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review

A. Rani, G. Singh, A. Singh, U. Maqbool, G. Kaur and J. Singh, RSC Adv., 2020, 10, 5610 DOI: 10.1039/C9RA09510A

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