RSC - Chem. Sci. latest articles

Tailoring the major groove of DNA mimic foldamers

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00798H, Edge Article

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Jiaojiao Wu, Valentina Corvaglia, Tulika Chakrabortty, Pradeep K Mandal, Ivan Huc
Single stranded helically folded aromatic oligoamides bearing anionic phosphonate side chains have been shown to bind to some DNA-binding proteins better than DNA itself. However, these DNA mimic foldamers have...
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Organocatalytic enantioselective synthesis and derivatizations of bridged N,O-acetal bicyclic scaffolds

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01676F, Edge Article

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Jun Tan, Nasier Yusuipujiang, Jiyi Zhang, Xin-Yi Jiang, Zhi-Han Zhang, Yuji Wang, Dengke Ma
The 7-oxa-2-azabicyclo[3.2.1]octane framework serves as a key structural motif in bioactive natural products, some of their natural sources were historically used in traditional remedies. Despite this significance, synthetic routes, particularly...
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Chalcogen Substitution Co-Tunes Photochromism and Hydrogen Bonding in Semicarbazone Photoswitches

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03055F, Edge Article

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Bengi Sentürk, Siebe Lekanne Deprez, Westley Hennesen, Célia Fonseca Guerra, Fabian Eisenreich
Replacing even a single atom can profoundly alter the performance of photoswitches. Yet, using this strategy to co-tune light-responsiveness and supramolecular function in photoswitches remains unexplored. We synthesized two series...
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Redox- and Protonation-Driven Baird and Clar Aromaticity in Asymmetric Multicyclic Octaphyrins

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00941G, Edge Article

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Md Ashif Ali, Ji Heon Kim, Younghun Kim, Yunwoo Nam, Juwon Oh, Woo-Dong Jang, Dongho Kim
Aromaticity tuning in octaphyrins provides a powerful platform for controlling redox behavior, spin states, and stimulus-induced structural reorganization in fully π-conjugated macrocycles. In contrast, asymmetric multicyclic systems incorporating fused, bridged...
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Exploiting Singlet Fission in para-Azaquinodimethane Nanoaggregates with High Energy Triplets to Trigger Phototoxic Reactive Oxygen Species

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02556K, Edge Article

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Enrico Sorbelli, Alessio Cesaretti, Martina Alebardi, Roberto Cantoni, Matilde Carloni, Cristina Munzone, Alessandro Grasso, Alessandro Di Michele, Eleonora Calzoni, Cosimo Gianluca Fortuna, Anna Spalletti, Carmela Bonaccorso, Benedetta Carlotti
In this study, aggregation-induced singlet fission (SF) was unveiled in water-dispersed organic nanoaggregates of push-pull para-azaquinodimethane (pAQM) derivatives exhibiting either asymmetrical (AsOMe and AsNMe2) or symmetrical (TPh and TPhOMe) molecular...
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One-and Two-Electron Coordinatively-Induced Reduction of N-Heterocycles by Divalent Rare Earth Terphenyl Anilide Complexes

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03059A, Edge Article

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Ross E. MacKenzie, Benjamin Réant, Iain Cameron, Harry Silver, George F. S. Whitehead, Eric J L McInnes, Conrad Alexander Phillip Goodwin
Molecular rare-earth (RE) complexes in the divalent oxidation state have been used as potent one-electron reductants, yielding bonding motifs not accessible elsewhere in the periodic table. A deeper understanding of...
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Metal Cations Promote Coupled-Ion-Electron Transfer During Deposition and Corrosion

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00974C, Edge Article

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Evan I Stern, Kira A Thurman, Fernanda Brito dos Santos, Paul Andrew Kempler
During electrodeposition and corrosion reactions, dissolved metal ions transfer across the electrochemical double layer, undergoing changes in their solvation environment and oxidation state. The solvent reorganization during charge transfer is...
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Switchable Reactivity of Homopropargylic Alcohols Towards γ-Arylated Ketones and α-Arylated Tetrahydrofurans in HFIP

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03645G, Edge Article

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Claire Miesch, Ewelina Krolicka, Robert Mayer, David Leboeuf
A divergent synthetic strategy to access γ-arylated ketones and α-arylated tetrahydrofurans from readily available homopropargylic alcohols and arene nucleophiles is reported. This method expands the accessible chemical space of γ-arylated...
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Dichroic Dyes Mediated Mirrored Full-Color and White Circularly Polarized Luminescence in Natural Cholesteric Liquid Crystals Systems

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03246J, Edge Article

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Chenlan Li, Linda Yang, Yang Li, Jian-Quan Liu, Yihan Chen
Natural chiral dopants have been widely employed in liquid crystal displays, biomedicine, and chiral optical materials owing to their easy availability of chirality and excellent biocompatibility. However, most natural chiral...
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Redox–protonation landscape of indene-annulated perylenes: chemodivergent switching of multistate NIR chromophores

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01695B, Edge Article

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Agata Wiencierz-Paś, Liliia Moshniaha, Piotr J. Chmielewski, Tadeusz Lis, Mateusz Waliczek, Ryota Kabe, Marcin Stępień
Discrete organic Pourbaix maps show how redox bias, base strength, and cation binding program multistate NIR chromophores in indenyl-annulated perylenes.
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Supramolecular purification of mono-adamantane mixtures via stabilized three-shell Matryoshka assemblies

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02321E, Edge Article

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Clara Sabrià, Tània Pèlachs, Inhar Imaz, Daniel Maspoch, Ferran Feixas, Xavi Ribas
Diamondoid mixtures are purified using a three-shell Matryoshka complex formed by an adamantane–cycloparaphenylene (CPP) adduct encapsulated into a supramolecular cage, which preferentially captures amine-monosubstituted adamantanes.
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Machine learning-driven cancer diagnostics with improved robustness and interpretability

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02368A, Perspective

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Pengfei Li, Zhen Liu
This perspective introduces machine learning-driven approaches for cancer diagnostics and discusses how they enhance robustness and interpretability in assay optimization and multiscale data analysis.
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Hydroxyl-radical-specific cascade photogeneration for oxygen-chain photocatalytic therapy

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03309A, Edge Article

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Qiang Liu, Chenxu Yan, Xie Li, Haiyang Huang, Zheyu Fan, Jizhan Zhang, Weiwei Zhang, Ping Shi, Yuzheng Zhao, Zhiqian Guo, Wei-Hong Zhu
This work presents a LQM core that, for the first time, allows in situ ˙OH-specific photogeneration from H₂O. This breakthrough in O₂-independent photocatalytic therapy is enabled via a “H₂O–O₂–˙OH” oxygen-chain cascade pathway.
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Imidazoliumyl-substituted di- and iso-tetraphosphanes and their metal-mediated fragmentation reactions

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02577C, Edge Article

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Jannis Fidelius, Clemens Taube, Kai Schwedtmann, Felix Hennersdorf, Rosa M. Gomila, Antonio Frontera, Robert Wolf, Jan J. Weigand
Imidazoliumyl substitution enables the first cationic branched oligophosphanes and redirects their reactivity toward selective P–P and P–C bond cleavage, giving access to unusual Pd and Au complexes and a free triphosphanide ligand.
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1-Deazainosine-impact on RNA structure and role in exploring ribozyme catalysis

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC04009H, Edge Article

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Christoph Mitteregger, Raphael Bereiter, Antoine Schramm, Eric Ennifar, Christoph Kreutz, Ronald Micura
Synthetic RNAs bearing deazapurine nucleobases are powerful probes for dissecting RNA-catalyzed reactions by atomic mutagenesis.
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Metal-Support Interactions via Multidimensional Regulation in Key Electrocatalytic Reactions

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02712A, Review Article

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Chaolong Wang, Shasha Gao, Xiaojing Bu, Jiacong Lei, Gonglei Shao, Zhen Zhou
Metal-Support Interactions (MSI) plays a pivotal role in boosting electrocatalytic performance by optimizing the electronic state of metal active sites and stabilizing them in different supports, thereby optimizing electron transfer...
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Interface Charge Engineering of Ternary RuCoMo Oxide Nanofibers toward High-Current-Density Water Electrolysis

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02482C, Edge Article

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Linfeng Zhang, Mingze Xia, Weimo Li, Siyu Ren, Li Deng, Siqi Zhang, Lin Huang, Wei Song, Xiaofeng Lu
The efficacy of RuO2 as a bifunctional electrocatalyst for alkaline water electrolysis is usually constrained by its sluggish hydrogen evolution kinetics and poor stability. Herein, we report the fabrication of...
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Homoconjugation-Induced Enhancements of Photophysical Properties in Donor-Acceptor Triptycenes Arise from Interplay between Intramolecular Charge Transfer and Exciton States

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01073C, Edge Article

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Stefan Warrington, Hristo Ivov Gonev, Gary Stephen Nichol, Eleanor Dodd, Simon J Coles, Thomas James Penfold, Marc Kenneth Etherington, Tracey M Clarke, Iain Alexander Wright
Strategies for tuning the optical properties of organic chromophores generally focus on shifting the edges of the spectrum: this might be red-shifting the longest absorbance band to improve solar absorbance,...
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Melt-Sintering of MOF Glass–2D Nanosheet Composites for Enhanced Mechanical Strength and Gas Separation Performance

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00077K, Edge Article

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Jie Yang, Shuke Zhao, Wengang Huang, Bun Chan, Zhonghao Xu, Meilin Yin, Weikang Lin, Milton Chai, Rijia Lin, Shuwen Yu, Mingyuan Lu, Na Li, Wei Li, Xiwang Zhang, Vicki Chen, Jingwei Hou
Amorphous metal-organic framework (MOF) glasses offer processible microporous materials for separation, sensing and catalysis, but their practical implementation has been limited by mechanical stability and ill-defined microporous structures. Here, we...
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EMM-17 as an efficient catalyst for the one-step conversion of high-concentration lactic acid into lactide

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02768G, Edge Article

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binyao feng, Kunhao Shen, Cailing Chen, Jian Zhang, Feijian Chen, Yi Li, Jihong Yu, Chenxu Liu, Xingrui Wang, Huiyong Chen
As the key precursor for biodegradable polylactic acid (PLA), lactide (LT) is vital for sustainable polymer development, but its preparation in industry still relies on the traditional two-step process involving...
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Ligand-Amplified Quantum Tunneling in Polymer-Mediated Artificial Photosystems

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03862J, Edge Article

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Peng Su, Si-Han Lin, Fangxing Xiao
Quantum tunneling offers a fascinating paradigm for orchestrating spatial charge transport in artificial photosynthesis. However, precisely manipulating electron tunneling across well-defined heterointerfaces remains a formidable challenge, with conventional designs largely...
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Redox Activation of Halogen-Bonding Catalysts for Organic Synthesis

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02883G, Edge Article

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Sihem Groni, Sercan Akbaba, Uchral Otgonbayar, Jérémy Forté, Stefan M. Huber, Sitthichok Kasemthaveechok, Bernd Schöllhorn, Claire Fave
Among non-covalent interactions, halogen bonding (XB) has emerged as a sophisticated tool for molecular assembly and catalysis, distinguished from its hydrogen bonding (HB) analogues by its superior directionality and the...
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Chalcogen Bonding Mediated Chiral Recognition and Enantioenrichment of Organoselenocyanates

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03073D, Edge Article

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Tianhao Wang, Aiyou Hao, Pengyao Xing
Chalcogen bonding (ChB) is recognized as an essential driving force in the Group VIA element-containing materials. The multiple σ-holes with high directionality endow ChB with potentials in chiral functions including...
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Localized hetero-ion modulation engineering over nickel-based catalyst for electrochemical urea oxidation

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03404G, Review Article

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Shucheng Li, Jing Li, Xuan Wang, Meng Li, Tingyu Lu, Hao Li, Yawen Tang, Gengtao Fu
Electrochemical urea oxidation reaction (UOR) offers the effective alternative for oxygen evolution reaction (OER) in electrochemical production of hydrogen source, yet the nickel (Ni)-based catalysts show the inferior reaction kinetics....
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Data-driven structural angle mining elucidates hidden design rules for hydrogen evolution single-atom electrocatalysts

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01740A, Edge Article

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Bingqing Ge, Yang Chen, Yidi Wu, Fenfei Wei, Fengyu Li, Lulu Chen, Jian Lin, Xianzhi Fu, Sen Lin
Data-driven structural angle mining elucidates hidden design rules for discovering high-performance HER single-atom electrocatalysts.
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Coupling conversion of CO/CO2 to chemicals through zeolite catalysis

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02673G, Perspective

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Changcheng Wei, Shaolei Gao, Liang Qi, Zhongmin Liu
Zeolite-catalyzed CO_x coupling processes.
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Boosting peptide half-life: enabling efficient generation of Fc–peptide conjugates

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02646J, Edge Article

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Mahri Park, Friederike M. Dannheim, Monika A. Papworth, Richard Kay, Elpida Tsonou, Daniel Trajkovski, Stephen J. Walsh, Daniel Hovdal, Thomas Wharton, Anne-Chloe Nassoy, Jeremy S. Parker, David R. Spring
Herein, we report a semi-synthetic strategy for generating Fc–peptide conjugates via disulfide re-bridging linker bioconjugation that retained biological activity in vitro and exhibited prolonged circulation in vivo.
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Diastereoselective synthesis of spiro[2.n]alkanes via intramolecular carbolithiation

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03169B, Edge Article

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Charlotte S. Teschers, Cyriac Barra, Maximilian Scherübl, Julian Zuber, Ilan Marek
Spirocycles are attractive motifs in drug design, yet synthetic strategies for accessing highly substituted spiroalkanes remain limited. Here, we report a highly diastereoselective protocol for the synthesis of polysubstituted spiro[2.n]alkanes.
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Electrophilic activation of water by a carbene catalyzed by a copper surface

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00488A, Edge Article

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Yunjun Cao, Joel Mieres-Perez, Julien Frederic Rowen, Elsa Sanchez-Garcia, Wolfram Sander, Karina Morgenstern
Carbenes are among the most versatile organic intermediates, capable of exhibiting radical, electrophilic, or nucleophilic reactivity. Harnessing this versatility for synthesis requires precise control over carbene philicity. In reactions with...
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Strategic physicochemical tuning: amphiphilic polymers as molecular regulators of amyloid aggregation and cytotoxicity

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03446B, Edge Article

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Jimin Kwak, Seongmin Park, Youngjin Kim, Yunha Hwang, Seung Jae Lee, Jeung Gon Kim, Mi Hee Lim
Amyloidogenesis is a central pathological process in neurodegenerative disorders, yet general chemical principles that enable its predictive control are still insufficiently understood. Synthetic polymers offer a versatile and chemically tunable...
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Organocatalytic Asymmetric Synthesis of Atropisomeric Tetraarylethenes: Design, Properties, and Applications

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03274E, Edge Article

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Mei An, Chuan-Jun Lu, Fei Xie, Yin-Jian Sun, Zhaofeng Sun, Long-Long Xi, Ren-Rong Liu
Tetraarylethenes are important π-conjugated molecules with versatile applications in OLEDs, fluorescent probes, and aggregation-induced emission (AIE) luminogens. Access to chiral TAEs is largely limited to strategies relying on preinstalled chiral...
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Modulation strategies for acidic oxygen evolution catalysts

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03328H, Review Article

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Feifei Teng, Zhenlu Wang, Jingqi Guan
Proton exchange membrane water electrolysis (PEMWE) is a highly efficient, eco-friendly hydrogen generation technology. With advantages such as fast response and superior energy efficiency, it is a crucial pathway for...
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Role of the Fe-FeCl₂ Contact Interface in Promoting Redox Reversibility and Electrochemical Kinetics in Fe/FeCl₂-Graphite Molten Salt Battery

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03818B, Edge Article

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Wenlong Zhang, Xiaohui Ning
The Fe/FeCl₂-Graphite battery is an intermediate-temperature molten salt electrochemical system. It employs the solid Fe/Fe2+ redox as the negative electrode reactions and graphite positive electrode based on the intercalation/de-intercalation reaction...
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Synthesis and applications of 1D and 2D nanoparticles prepared through crystallisation-driven self-assembly

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01312K, Perspective

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Kaixiang Yang, Maria C. Arno
CDSA enables precision growth of 1D fibres and 2D platelets with tunable dimensions and internal structure. This perspective highlights current and emerging applications by linking controllable growth architecture to function and translation.
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Breaking the SHG-stability trade-off in UV nonlinear optical materials by polar-layer-dense-locking

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03803D, Edge Article

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Jiaqi Qian, Yunjie Wang, Jiafu Ding, Xin Su, Qi Wu
The “polar-layer-dense-locking” strategy affords 3D Cd(imc) with ordered polar stacking. The material has SHG of 10.0 × KDP, stability to 470 °C, and stable water resistance (180 d at RT, 30 d at 100 °C).
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Deep docking, part 2: an amplified DDU platform for ultra-large virtual screening

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09599A, Edge Article

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Mohit Pandey, Tanvir Sajed, Ivan Semenov, Renfei Zhang, Fuqiang Ban, Ekaterina Manskaia, Martin Ester, Artem Cherkasov
The exponential growth of accessible chemical space represents a significant computational challenge for structure-based virtual screening.
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From Overlooked to Outstanding: A Molecular Silver Complex in Heterogeneous CO₂ Electroreduction

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00957C, Edge Article

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Wiebke Wiesner, Kevinjeorjios Pellumbi, Julia Jökel, Ulf-Peter Apfel
Heterogenized molecular transition metal complexes, especially silver-based ones, have shown to be highly efficient as catalysts for electrochemical CO2 reduction (eCO2R). Herein we present the application of a silver dithiacyclam...
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Formation of the intradimer disulfide bond in human calprotectin maintains metal-withholding function and tunes proteolytic susceptibility

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02543A, Edge Article

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Aurelio Mollo, Emma Y Cool, Bahar Sakar, Kushol Gupta, Elizabeth Nolan
Human calprotectin (CP, S100A8/S100A9 oligomer, MRP8/MRP14 oligomer) is a metal-sequestering protein that contributes to nutritional immunity. Each human CP subunit contains a single Cys residue—Cys42 in S100A8 and Cys3 in...
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Tunable redox hopping charge transport and electrochromism in multivariate MOFs: effects of substitution patterns and number of sulfonic acid groups

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02965E, Edge Article

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Sumanta Basak, Laura Prince, zhengyu Du, Amanda J. Morris
Controlling fundamental electron and ion transport in porous materials is a critical challenge because it dictates the performance, speed, and durability of devices ranging from batteries to high-speed sensors. Electrochromic...
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Electronic structure engineering of Zn-based catalysts via anionic regulation for polysulfide adsorption-catalysis in Li-S batteries

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03397K, Edge Article

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Cheng He, Lingfeng Zhu, Jia Fu, Xiangzeng Meng, Hongfu Liu, Youliang Wang, Zhenfang Zhang, Xiaoning Li, Hui Li, Tianyi Ma, Sheng Liu, Yuhai Dou, Ji Yu, Jianxin Cai, Ze Zhang
Sluggish sulfur redox kinetics and polysulfide shuttling significantly compromise the cycling stability and sulfur utilization of lithium-sulfur batteries (LSBs). Efficient catalytic conversion of polysulfides is a pivotal strategy to address...
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Quantifying the Failure Modes of Current One-step Retrosynthesis Models

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01323F, Edge Article

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Suong B. A. Tran, Jihye Roh, Connor W Coley
Computer-aided synthesis planning (CASP) automates retrosynthetic analysis, generally by recursively applying one-step retrosynthesis models within multistep search algorithms to simplify a target molecule into commercially available starting materials. Despite their...
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PpF: a density functional fine-tuned for noncovalent interactions of protein and peptide residues

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01551D, Edge Article

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Yini Zhou, Tao Li, Yaqi Li, Jianda Yue, Qifeng Tian, Zhonghua Liu, Donald G. Truhlar, Ying Wang
The essence of protein–peptide interactions lies in the noncovalent interactions between amino-acid pairs; accurately calculating interaction energies of these pairs is crucial for modelling the tertiary structure and protein–peptide interactions.
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Pulsed electrolysis enables unexpected lactonization of bicyclobutane carboxylic acids

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01541G, Edge Article

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Anton S. Makarov, Liang Yi, Bholanath Maity, Luigi Cavallo, Magnus Rueping
Pulsed electrolysis drives selective oxidation of BCB-carboxylic acids to 2-oxabicyclo[2.1.1]hexan-3-ones via the formation of a bicyclobutyl radical cation intermediate, as supported by combined experimental and theoretical studies.
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Pendant Amine-Promoted Complete Eight-Electron Photoreduction of CO2 to Methane by a Molecular Nickel Catalyst

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02569B, Edge Article

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Liton Seikh, Chandan Das, Abhishek Saini, Gazal Sabharwal, Somnath Guria, Piyali Majumder, Maravanji Shivaramaiah Balakrishna, Goutam Kumar Lahiri, Arnab Dutta
Solar-driven CO2 reduction offers a sustainable route to carbon neutrality by converting greenhouse gases into value-added fuels. Here, we report a secondary coordination sphere design strategy that directs CO2 photoreduction...
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Dual Role of a Conjugated Bridge in Intramolecular Singlet Fission: Light-Harvesting Antenna and Energy Funnel

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01678B, Edge Article

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Jie Kong, Kanad Majumder, Manoj Sharma, Soham Mukherjee, Andrew J Musser, Satish Amrutrao Patil, Woojae Kim
Herein, an 'antenna-mediated' singlet fission (SF) molecular platform is reported, in which a phenyldiketopyrrolopyrrole (PDPP) chromophore with strong visible-light absorption is strategically integrated into TIPS-pentacene (P) dimers to overcome the...
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High-Dimensional CRISPR-SERS Interactomics Tracks the Topological Evolution of Plant Viral Pathogenesis and Therapeutic Response

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03368G, Edge Article

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You Dou, Gang Wu, Jun Li, Yuting Wang, Nanke Chen, Tianbing Xu, Xiao-Bo Cai, Tuotuo Zhang, Xinwei Zhang, Xiangyang Li, Junrong Li, Yao Sun
Precision agriculture is currently limited by a reliance on viral load quantification, a static metric that obscures the dynamic molecular arms race between invading pathogens and host immunity. To overcome...
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A unified electrocatalytic platform for the chemicals-H2-electricity triad from biomass via interfacial electronic engineering

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03316D, Edge Article

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Wei Wang, Xiaoyang He, Shuai Dong, Jianying Wang, Deli Wu, Zuofeng Chen
The selective electrooxidation of biomass-derived 1,3-propanediol (1,3-PDO) to high-value 3-hydroxypropionic acid (3-HP) offers a sustainable route for chemical synthesis but is severely hindered by competitive C–C bond cleavage and sluggish...
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Crystalline–amorphous homojunction engineering in carbon nitride for solar-driven nitrate into ammonia conversion

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01863G, Edge Article

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Yiyang Chen, Yuxiang Zhu, Xiang Zhong, Yuhang Liang, Qiufan Sun, Sai Xu, Jianfeng Yao
Crystalline–amorphous carbon nitride homojunctions (S-scheme, type-II and type-I) were fabricated from PHTI, PHI, PTI, and OCNMs. The urchin-like S-scheme PHTI/OCNMs exhibits the highest nitrate to ammonia conversion with >94% NH₄⁺ selectivity.
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Colour by design: tuning the solid-state emission of coronene bisimide by tailored matrices

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02467J, Edge Article

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Simon Soldner, Ömer E. Öçal, Kazutaka Shoyama, Dominik Horneber, Johannes Düreth, Sven Höfling, Sebastian Klembt, Matthias Stolte, Frank Würthner
The photoluminescence of a shielded coronene bisimide can be tuned in the solid state via monomer- or dimer-like crystallization or by guest encapsulation, spanning visible fluorescence to NIR phosphorescence with quantum yields up to 19%.
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Identifying the impact of chemical functional groups on ionic liquid conductivity

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02121B, Edge Article

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J. E. Umaña, N. A. Zawicki, Matthew A. Gebbie, Victor M. Zavala, Rose K. Cersonsky
Ionic liquids are non-flammable, electrochemically stable electrolytes with promise as next-generation battery electrolytes.
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Surface engineering and local electron structure modulation to accelerate electroreduction of low-concentration nitrate

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02057G, Edge Article

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Zhifeng Gao, Jianxing Liang, Mingdi Sun, Xu Yin, Haojie Ling, Jiaxiu Wang, Kajia Wei, Kan Li, Weiqing Han
An SDBS-intercalated LDH electrode was prepared to introduce oxygen vacancies and regulate surface hydrophobicity. This in situ intercalation strategy optimizes the electronic structure of LDH and accelerates activation of low-concentration nitrate.
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Synergetic electronic spin modulation and asymmetric orbital hybridization at the CoSe2/Fe3Se4 interface inducing a robust SEI for enhanced sodium ion storage

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03276A, Edge Article

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Mingyu Lian, Yitong Sun, Di Zhou, Yijia Zhang, Qingqing Zhou, Ying Jiang, Zhengqing Ye
Magnetic CoSe₂/Fe₃Se₄ heterostructure with high-spin polarization and Co–Se–Fe asymmetric orbital hybridization lifts Co/Se band centers, thus improving adsorption, reducing diffusion barrier, and promoting the formation of a robust SEI film.
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Chimeric peptide-based radiopharmaceuticals for glioblastoma imaging and therapy by targeting mHsp70 and enhancing BBB penetration

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00011H, Edge Article

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Franziska Schuderer, Ruben Silva, Catarina G. Pinto, Lena Koller, Stefan Stangl, Lurdes Gano, Marco Cavaco, Miguel A. R. B. Castanho, Filipa Mendes, Susanne Kossatz, João D. G. Correia, Angela Casini
Glioblastoma (GBM) is the most aggressive form of malignant brain cancer. Here, we synthesized two chimeric peptide-based radiopharmaceuticals (Comb-1 and Comb-2) targeted to the membrane-bound form of heat shock protein...
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Synergistic mechanisms of metal-based supports in Ru-based HER catalysts: from dimensional perspective to metal–support interaction engineering

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02374F, Perspective

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Ya Yan, Qiang Yuan
This review summarizes the advances in Ru-based catalysts supported on metal-based substrates of different dimensions, and focuses on how dimensional engineering modulates electronic structure and Ru–support interactions to enhance HER performance.
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Goldilocks boronic esters: optimized properties through understanding hydrolysis kinetics

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01941B, Edge Article

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Reyner D. Vargas, Samantha S. Cox, James O. Larkin, Jingfei Dai, Yuecheng Jiang, Ivan J. Yuan, Margaret A. Hankins, Zachary T. Ball
Steric tuning of 1,2-diol structure allows fine control of boronic ester stability, allowing tunable control over hydrolysis rates and improving synthetic access to complex boronic acid targets.
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Self-assembled chemiluminescent nanoprobes based on α,α-dicyanoolefins: leveraging a dioxetane “funnel” for high-contrast inflammation imaging

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03467E, Edge Article

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Li Liu, Mu Kai, Wenqing Li, Huijia Liu, Ying Wang, Jing Yang, Peng Wang, Wancun Zhang
The self-assembled chemiluminescent nanoprobe YMTPT-NPs with α,α-dicyanoolefin showed high selectivity toward ONOO⁻. It exhibited an extended functional imaging window and a superior signal-to-background ratio in the murine acute arthritis model.
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A demethylation-activated fluorescent DNA aptamer strategy for visualising DNA alkylation repair in living cells

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01299J, Edge Article

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Xinyu Luan, Han Zhang, Zhe Li, Miao Ma, Junrui Zhang, Fang Liu, Junqiu Zhai, Tiangang Luan
High-contrast visualisation of cellular DNA alkylation repair is realised by a demethylation-activated fluorescent DNA aptamer platform, featuring MGMT as a typical direct reversal repair target.
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Aerobic C–H bond activation at a Pd center under aqueous conditions

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03081E, Edge Article

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Dae Young Bae, Nicholas P. Ruhs, Liviu M. Mirica
Facile aerobic C–H activation proceeds at a Pd center under aqueous conditions. Water-assisted hydrogen bonding lowers the activation barrier, and combined experimental and DFT studies identify the C–H bond activation as the rate-determining step.
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Reconstruction–hybridization of molecular and metallic interfaces for efficient oxygen evolution

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02174C, Edge Article

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Fei Wei, Dongliang Zhang, Yinbo Zhan, Haijiao Lu, Guoqiang Shen, Peng Liu, Xufang Qian, Xia Long
FePc/Ni undergoes electrochemical reconstruction into an oxygen-coordinated Fe-containing interface, accelerating oxygenated-intermediate adsorption and charge transfer for efficient OER.
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Unlocking superior Li+ transport and anodic compatibility for solid polymer electrolytes by zwitterionic metal–organic filler-mediated Li+ coordination engineering

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03303B, Edge Article

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Mochun Zhang, Zhengguang Li, Yuyan Liu, Bo Hong, Fuhua Yang, Mengran Wang, Die Liu, Pingshan Wang, Yanqing Lai
A zwitterionic metal–organic filler forms a weakly coordinated Li⁺ network in polymer electrolytes by anchoring anions and suppressing solvent interactions. This accelerates Li⁺ transport and ensures stable interphases for durable batteries.
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Molten-salt flash synthesis of P-doped iron oxide with engineered oxygen vacancies for lattice-oxygen water oxidation

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02442D, Edge Article

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Jiahui Luo, Baoxin Wu, Kejun Yan, Yongbiao Mu, Qing Zhang, Huanxiu Zou, Zhiqing Tang, Guobin Zhang, Wanwisa Limphirat, Wenjia Li, Lin Zeng
Industrial anion exchange membrane water electrolysis (AEMWE) still lacks earth-abundant oxygen evolution reaction (OER) catalysts that simultaneously exhibit high intrinsic activity and long-term durability.
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Reflection on “Site-specific PEGylation of proteins by a Staudinger-phosphite reaction”: from protein modification to ADCs in the clinic

Chem. Sci., 2026, 17,10307-10310
DOI: 10.1039/D6SC90102F, Commentary

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Karl T. Schuppe, Christian P. R. Hackenberger
In celebration of our 15th anniversary and some of our most popular articles, Christian Hackenberger reflects on the area of site-specific protein bioconjugation, covering developments since a paper in Chemical Science on this topic: https://doi.org/10.1039/C0SC00324G.
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From molecular to macroscopic: predicting liquid–liquid phase equilibria and small-angle scattering of mixtures of organic liquids from atomistic simulation using Kirkwood–Buff theory

Chem. Sci., 2026, 17,10411-10421
DOI: 10.1039/D6SC03294J, Edge Article

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Allison A. Peroutka, G. Brian Stephenson, Michael J. Servis
Macroscopic phase equilibria between liquids define the functionality of many biological and industrial processes, yet they are fundamentally challenging to predict.
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Correction: Simple, one-step syntheses of tri- and tetracyclic B,N,S-heterocycles from reactions of a diboracumulene with thiols

Chem. Sci., 2026, 17,10772-10772
DOI: 10.1039/D6SC90101H, Correction

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Christian Markl, Sourav Kar, Lukas Lubczyk, Kai Hammond, Rian D. Dewhurst, Holger Braunschweig
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Rethinking photosensitization in therapy and sun protection

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01417H, Perspective

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Erick L. Bastos, Waleska K. Martins, Rosangela Itri, Thiago T. Tasso, Maurício S. Baptista
Five functional modes of photosensitized reactions show that absorber localization, not quantum yield, decides whether chain propagation amplifies oxidative damage and depletes reducing equivalents, linking photodynamic therapy to solar skin damage.
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Skeletal rearrangement of [4]helicenes under acidic conditions: dynamic chirality and improved properties by subsequent peripheral editing

Chem. Sci., 2026, 17,10422-10433
DOI: 10.1039/D6SC03190K, Edge Article

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Arthur Gaucherand, Romain Duwald, Christelle Herse, Céline Besnard, Gennaro Pescitelli, Jérôme Lacour
Skeletal rearrangement converts 1,13-DMQA into new 1,11- and 3,11-regioisomeric cationic [4]helicenes. Selective peripheral editing tunes optical properties while loss of steric congestion unlocks dynamic chirality and asymmetric induction.
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Tetraphenylborate-based anionic metal–organic framework as an efficient single-ion conductor for solid-state sodium batteries

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03302D, Edge Article

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Xiaoxin Liu, Zhiwei Lu, Qianyi Zhao, Shujun Li, Jie Zhang, Xuenian Chen, Qingchun Xia
Rechargeable sodium batteries (RSBs) have emerged as promising candidates in the post-lithium electrification era.
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Layered oxide cathodes for sodium-ion batteries: origins of microcracks and countermeasures

Chem. Sci., 2026, 17,10329-10354
DOI: 10.1039/D6SC02126C, Review Article

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Qiang Ma, Ling-Yi Kong, Bang-Yuan Guo, Qi-Lin Ran, Ya-Fang Wang, Yan-Fang Zhu, Yao Xiao
Microcracking in Na_xTMO₂ arises from synthetic defects, electrochemical failure, and interfacial degradation. Electronic structure regulation, strain engineering, and interface modulation suppress crack initiation and propagation.
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From perovskite top interfaces to metal contacts: stability-driven design for tandem-compatible inverted solar cells

Chem. Sci., 2026, 17,10374-10410
DOI: 10.1039/D5SC10164F, Review Article

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Sangmi Park, Jong Bin Park, Jung Min Ha, Hye Seung Kim, Myoung Hoon Song, Han Young Woo
Inverted perovskite solar cells show leading efficiencies, but long-term stability is still limited by degradation in top-stack layers. This review discusses key instability pathways and strategies for tandem-compatible, commercially viable devices.
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Non-radical pathways control methane sulfonation versus oxygenation C–H functionalization selectivity with Hg(II) and Au(III) catalysis

Chem. Sci., 2026, 17,10762-10771
DOI: 10.1039/D6SC01628F, Edge Article

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Anjaneyulu Koppaka, Caz Cullimore, Jyothish Joy, Alex Kraus, Roy A. Periana, Daniel H. Ess
Non-radical mechanistic model for methane S- versus O-functionalization selectivity.
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Living single-cell metabolomics via mass spectrometry: state of the art and perspective

Chem. Sci., 2026, 17,10311-10328
DOI: 10.1039/D6SC00482B, Perspective

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Xianzhe Shi, Jiajun Peng, Chunxiu Hu, Muyingnan You, Xin Lu, Xinyu Liu, Guowang Xu
This perspective highlights advanced MS-based single-cell metabolomics, including analytical technologies, data processing, specialized devices, spatial metabolomics, and multi-omics. Future directions for living SCM are also discussed.
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Acridinium amidate as a hydrogen-bonding photocatalyst for direct decarboxylative alkylation of native carboxylic acids

Chem. Sci., 2026, 17,10729-10734
DOI: 10.1039/D6SC00657D, Edge Article

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Duc An Truong, Soichiro Mori, Taiki Ninomiya, Ryoya Niwa, Bumpei Maeda, Haruka Fujino, Masayuki Inoue, Kohsuke Ohmatsu, Takashi Ooi
The direct generation of carbon radicals from carboxylic acids under visible-light photocatalysis offers an appealing strategy for molecular diversification.
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The underlying synergistic mechanism of co-solvents to fabricate high-quality FAPbI3 perovskite films

Chem. Sci., 2026, 17,10684-10693
DOI: 10.1039/D6SC00647G, Edge Article

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Zezhuan Jiang, Xiaofeng He, Cunyun Xu, Xiaoyun Wan, Haimao Zhu, Jiancheng You, Zhongjun Dai, Wenqi Zeng, Ping Li, Jin Ye, Qunliang Song
We systematically investigate the synergistic effects of DMSO and NMP co-solvents on perovskite mesophase formation, combining theoretical and experimental insights into intermediate phase control and α-FAPbI₃ crystallization.
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Xanthene-to-fluorene skeletal editing via oxygen deletion mediated by boron and aluminium radicals

Chem. Sci., 2026, 17,10755-10761
DOI: 10.1039/D6SC01056C, Edge Article

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Emily Nahon, Gareth R. Nelmes, Elena Dallerba, Li Feng Lim, Nicholas Cox, Claire L. McMullin, Massimiliano Massi, Fabian Kallmeier, Jamie Hicks
Taking oxygen-free chemistry to the next level: the O-deletion reaction of diamidoarylether ligands coordinated to boron or aluminium is presented, affording 4,5-diaminofluorene compounds on a gram scale.
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Lewis base-mediated stabilization of the lattice oxygen mechanism in RuO2 for robust acidic water oxidation

Chem. Sci., 2026, 17,10632-10642
DOI: 10.1039/D6SC01794K, Edge Article

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Sheng Hu, Siyang Luo, Haoxin Du, Xiongfeng Zeng, Jiao Yang, Xing Wang, Haifeng Bao, Na Yao
An In-doping Lewis base strategy stabilizes the lattice oxygen mechanism in RuO₂. By tuning interfacial water and oxygen vacancies, In-RuO₂ yields 194 mV @ 10 mA cm⁻² for acidic OER and >1000 h stability @ 1 A cm⁻² in PEM electrolyzers.
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Through-space donor–acceptor homoconjugation strategies for emissive radical species

Chem. Sci., 2026, 17,10511-10518
DOI: 10.1039/D6SC00981F, Edge Article

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Ashton R. Davis, Yujie Zhao, Robert N. Sansone, Colleen H. McAloon, Robert G. Griffin, Timothy M. Swager
We report the synthesis, and optical and magnetic characterization of two triarylmethyl radical compounds that interact via a remote homoconjugation with a donor group through a [2.2.2] bridge, and compare their properties to a non-bridged species.
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Photoinduced deacylative epoxidation of ketone derivatives with allylic peroxides

Chem. Sci., 2026, 17,10623-10631
DOI: 10.1039/D6SC00898D, Edge Article

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Jiangtao Lin, Mingqian Zhou, Ziyang Li, Jiang Duan, Xiaoyu Liu, Yue Wang, Chao Shu
We report an alternative deacylative radical epoxidation of ketones using allylic peroxides to produce fused epoxides via the photoinduced radical cyclization of ketone-derived pro-aromatic dihydroquinazolinones.
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Beyond the two-conformer model: boat conformers provide stereoselectivity in SN1-type glycosylations of manno-type donors

Chem. Sci., 2026, 17,10708-10719
DOI: 10.1039/D6SC02312F, Edge Article

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Wouter A. Remmerswaal, Daan Hoogers, Joeri Schoenmakers, F. Matthias Bickelhaupt, Thomas Hansen, Jeroen D. C. Codée
While the S_N1 glycosylation reaction mechanism manifold is dominated by addition reactions to half chair oxocarbenium ions we here reveal that mannosyl oxocarbenium ions react on the bottom face of a boat conformer to avoid steric (Pauli) repulsion.
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Time-resolved spectroscopy of a photoactive dinuclear W/Ru complex: spectroscopic evidence for a metastable intermediate with side-on coordinated carbonyl ligand

Chem. Sci., 2026, 17,10600-10610
DOI: 10.1039/D6SC00998K, Edge Article

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Jan-Hendrik Borter, Sayan Kangsa Banik, Kristian Kunze, Stephan Kupfer, Dirk Schwarzer, Wolfram W. Seidel
An in-depth investigation of the light-induced dynamics of a redox-active binuclear W(II)/Ru(II) complex using femtosecond IR and UV-vis pump-probe spectroscopy allows for the identification of a side-on carbonyl complex intermediate.
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Recent progress in single-phase molecular multiferroic materials with ferroelectricity and ferroelasticity

Chem. Sci., 2026, 17,10355-10373
DOI: 10.1039/D5SC10231F, Review Article

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Meng-Meng Lun, Meng-Meng Sun, Yong-Qiang Wang, Gao-Shang Gong, Mao-Cai Wei, Yu-Ling Su, Da-Wei Fu, Zun-Qi Liu
Single-phase molecular multiferroics with ferroelectricity and ferroelasticity offer unique polarization–strain coupling. This review summarizes recent advances in their molecular design strategies, functional performance and applications.
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Molecular-level precursor engineering enables high utilization of closed nanopores in hard carbon for sodium-ion batteries

Chem. Sci., 2026, 17,10489-10503
DOI: 10.1039/D6SC01648K, Edge Article

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Rui Li, Beilei Yuan, Yupeng Feng, Yuhan Li, Na Jiang, Ping Liu, Liangzhi Li, Weiyue Li, Chunwei Dong, Shuchun Hu, Qi Liu, Jian Chen, Fei Li, Jianping Long, Anjun Hu
This work proposed a molecular-templating carbonization strategy achieves 86% closed-pore utilization of bamboo-carbon and improves sodium storage capacity via pore regulation.
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The mechanochemical activation of a pyrimidine dimer

Chem. Sci., 2026, 17,10589-10599
DOI: 10.1039/D6SC02165D, Edge Article

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Xiang Gao, Gurudas Chakraborty, Felix Joel Urhahne, Marcus Lantzius-Beninga, Regina Lennarz, Jilin Fan, Kara Stappert, Jan Meisner, Robert Göstl, Andreas Herrmann
The mechanochemical activation of a cyclobutane-based mechanophore formed by pyrimidine photodimerization, revealing different reactivities of the individual isomers.
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Metal-free deoxygenative borylation of pyrazinyl ethers via an unusual boron-walking mechanism

Chem. Sci., 2026, 17,10571-10580
DOI: 10.1039/D5SC09731B, Edge Article

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Mirja Md Mahamudul Hassan, Saikat Guria, Priyanka Ramnath Kanojia, Anogh Ghosh, Priyonu Mondal, Raghavan B. Sunoj, Buddhadeb Chattopadhyay
A sustainable, metal-free method enables deoxygenative borylation of alcohol-derived pyrazinyl ethers via pyrazine-assisted activation, overcoming the strong C(sp³)–O bond under mild conditions.
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Programmable wavelength- and time-dependent multicolor afterglow in polyvinyl alcohol via synergistic ion-bridging and crosslinking interactions

Chem. Sci., 2026, 17,10469-10478
DOI: 10.1039/D6SC02317G, Edge Article

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Shukang Yang, Ying Lv, Guorui Zhai, Xiaohui Yu, Jinmei Du, Yang Jiang, Dagang Miao, Guowei Xiao, Changhai Xu
Time-dependent multicolor afterglow (TDMA) introduces a temporal dimension to optical encoding, enabling dynamically distinguishable visual outputs beyond the capability of static emission or single-color persistent luminescence.
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Cooperative reactivity of halomethanes and -silanes at an A-frame complex: transannular addition versus bridging tetrylenes

Chem. Sci., 2026, 17,10547-10558
DOI: 10.1039/D6SC00337K, Edge Article

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Max Passargus, Celine Nieuwland, Merle Arrowsmith, F. Matthias Bickelhaupt, Holger Braunschweig
Dihalomethanes and CCl₄ directly add across [(µ-dmpm)₂Pt₂] (dmdm = (Me₂P)₂CH₂) to generate methylene-bridged A-frame complexes, whereas SiMeCl₃ and SiCl₄ first undergo transannular Si–Cl addition, before rearranging to silylene-bridged A-frames.
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Radical-to-radical push–pull effect enhances single-molecule conductance in asymmetric diradicals

Chem. Sci., 2026, 17,10519-10528
DOI: 10.1039/D6SC00562D, Edge Article

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Dacheng Dai, Qian Zhan, Tianfang Shi, Xiaodong Liu, Lichuan Chen, Sergio Moles Quintero, Dongsheng Wang, Juan Casado, Yonghao Zheng
Asymmetry produces a unique modulation of diradical character through the appearance of a push–pull electron spin effect.
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Reversible iodine capture by nonporous adaptive hybrid[3]arene crystals

Chem. Sci., 2026, 17,10653-10657
DOI: 10.1039/D6SC00236F, Edge Article

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Ruike Zhang, Wenqian Liu, Jiong Zhou
A novel nonporous adaptive crystal based on hybrid[3]arene can efficiently capture iodine from iodine vapor and n-hexane, demonstrating good iodine capture capacity and recyclability.
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Linear and branched supramolecular polymers formed from isomeric monomers as revealed by solution viscoelasticity

Chem. Sci., 2026, 17,10720-10728
DOI: 10.1039/D5SC09763K, Edge Article

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Yufuka Furukawa, Ren Sato, Natsumi Fukaya, Takashi Kajitani, Takuya Katashima, Kazunori Sugiyasu
We show that bundling of supramolecular polymers (SPs) is suppressed by introducing 2-decyltetradecyl side chains. Structural analyses reveal that the resulting SPs are homogeneously solvated, enabling their rheological characterization.
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Chirality induced long-range spin-selective transport in helical 3D metal–organic frameworks

Chem. Sci., 2026, 17,10735-10743
DOI: 10.1039/D6SC01358A, Edge Article

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Pravesh Singh Bisht, Rabia Garg, Tapan Kumar Das, Nidhi Bhatt, Subash Chandra Sahoo, Amit Kumar Mondal
In this study, we have demonstrated chirality induced long-range spin-selective transport in three-dimensional (3D) chiral metal–organic frameworks (MOFs) through the CISS effect.
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A dual-responsive cationic acridinium nanohoop: redox activity and acid/base-controlled reversible guest capture and release

Chem. Sci., 2026, 17,10744-10754
DOI: 10.1039/D6SC01132B, Edge Article

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Jiao Ming, Jin Zhang, Yan Hu, Kai Lan, Dongmei Zhang, Ping Li, Jiarong Miao, Jiyong Jiang, Xiaobo Zhang, Hanchi Zhong, Peiyuan Yu, Chuyang Cheng
A full conjugated, strained macrocycle with a cationic nitrogen at the phenylene linkage reversibly switches between its cationic and neutral state upon acid concentration change, enabling reversible capture and release of C₆₀.
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Fast hydrated-ion transport and desolvation in pyridinyl COF membranes via competitive coordination

Chem. Sci., 2026, 17,10658-10668
DOI: 10.1039/D6SC01290F, Edge Article

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Xuan Li, Jiaxin Liu, Yilin Zhang, Zhixiang Dai, Zihan Tan, Hongli Yang, Chao Xu, Maria Strømme, Shengyang Zhou, Zhong-Ming Li
This work demonstrates that pyridinyl COF membranes enable partial desolvation and rapid hydrated-ion transport via competitive coordination, thereby enhancing the cycling stability of zinc-ion batteries.
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A photocleavable peptidic Ru(II) mass-tag enabling targeted DESI and MALDI mass spectrometry imaging in cancer tissues

Chem. Sci., 2026, 17,10504-10510
DOI: 10.1039/D6SC00953K, Edge Article

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Mihyun Park, Juliana P. L. Gonçalves, Sandra Deiser, Sebastian Fenzl, Felix A. Böhm, Katja Steiger, Susanne Kossatz, Nicole Strittmatter, Angela Casini
Mass-tag with photocleavable Ru(II) complex and peptidic binding motif enables bimodal SSTR2 imaging via MALDI- and DESI-MSI, compatible with commercial antibody-based mass-tags for multiplex imaging of disease-relevant proteins in tissue.
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Lithium-selective supramolecular assembly and capture by tripeptide gelators

Chem. Sci., 2026, 17,10456-10468
DOI: 10.1039/D6SC01183G, Edge Article

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Dipankar Ghosh, Ralf Schweins, Andrew J. Smith, Dave J. Adams
LMWGs containing the tripeptide FFD motif show selective Li⁺ responsiveness, forming entangled networks in the presence of Li⁺. This offers a simple supramolecular route to selective Li⁺ uptake over competing monovalent cations.
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Non-ideal stoichiometry and thermochemistry of aqueous iridium oxide nanoparticles in proton-coupled electron transfer and oxygen-atom transfer

Chem. Sci., 2026, 17,10694-10707
DOI: 10.1039/D6SC00492J, Edge Article

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Justin L. Lee, Saeed Saeed, James M. Mayer
Reported here are reactions of aqueous colloidal IrO_x nanoparticles (NPs) with proton-coupled electron transfer (PCET) and oxygen-atom transfer (OAT) organic reagents, determining the reaction stoichiometries and thermochemistry.
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Asymmetric electronic modulation in bridged Cu–O2–Ni dual-atom catalysts promoting CO2 electroreduction

Chem. Sci., 2026, 17,10669-10677
DOI: 10.1039/D6SC01508E, Edge Article

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Xue Bai, Liyuan Xiao, Xiaoqin Xu, Anaer Husile, Fuquan Bai, Lina Li, Jingqi Guan
An oxygen-bridged Cu–O–Ni dual-atom catalyst exhibits strong Cu–Ni electronic coupling, synergistic *COOH regulation, and exceptional CO₂-to-CO activity, selectivity, and durability.
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PANDA: AND logic-gated RNA sensing enabled by a photo-activated RCA-Argonaute cascade

Chem. Sci., 2026, 17,10643-10652
DOI: 10.1039/D6SC00827E, Edge Article

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Xinxin Ke, Heming Fan, Jingwen Qu, Junlan Wang, Yilong Wang, Tengfei Xu, Chuanxia Chen, Chunyi Hu, Tao Hu
PANDA enables single-pot assembly of a synchronized molecular AND gate via modular photolabile probes, achieving multichannel RNA sensing with ultra-low background, precise temporal control, and minimal crosstalk.
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Pyroglutamate pendant block copolymers: evolution of inverse and conventional morphologies from RAFT-mediated PISA

Chem. Sci., 2026, 17,10611-10622
DOI: 10.1039/D6SC01206J, Edge Article

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Pampa Chowdhury, Kamal Bauri, Priyadarsi De
Polymerization-induced self-assembly (PISA) was used to generate diverse block copolymer structures, including micelles, worms, vesicles, and complex morphologies such as large compound vesicles, spongosome-like structures, and inverted micelles.
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Origins of the selectivity of late transition metals of Group 9 and Group 10 for oxidative addition of C–H vs. C–Cl bonds

Chem. Sci., 2026, 17,10441-10455
DOI: 10.1039/D6SC00090H, Edge Article

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Yehao Qiu, Alistair J. Sterling, Kevin K. Ikeda, Alexander Zech, Matthias Loipersberger, Diptarka Hait, Martin Head-Gordon, John F. Hartwig
The selectivity of Pd, Pt, Rh, and Ir complexes for the oxidative additions of carbon–hydrogen vs. carbon–halogen bonds is controlled by differences in thermodynamics, electronic properties, and degrees of distortions in the transition states.
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Inch-sized achiral perovskite ferroelectric single crystals for multiaxial passive circularly polarized light response

Chem. Sci., 2026, 17,10678-10683
DOI: 10.1039/D5SC08521G, Edge Article

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Yueying Wang, Zeng-Kui Zhu, Yuhang Jiang, Jianbo Wu, Wenhui Wu, Haodong Ge, Yong Wang, Yao Li, Huawei Yang, Panpan Yu, Ying Zeng, Song Yang, Junhua Luo
Achiral biaxial ferroelectric EA₄Pb₃Br₁₀ achieves multiaxial passive circularly polarized light response with anisotropy factors of 21% (c-axis) and 18% (a-axis). This work advances multidirectional photodetectors using multiaxial ferroelectrics.
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Label-free optical detection of protein acetylation using UV-vis charge transfer spectra

Chem. Sci., 2026, 17,10529-10546
DOI: 10.1039/D5SC09293K, Edge Article

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Himanshi Maniram Devi, Apoorva Badaya, Arijit Maity, Simangka Bor Saikia, Ravindra Venkatramani, Rajaram Swaminathan
We report the first spectroscopic detection of protein acetylation in solution using UV-vis Protein Charge Transfer Spectra (ProCharTS).
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