RSC - RSC Med. Chem. latest articleshttp://pubs.rsc.org/en/Journals/Journal/MDRSC - RSC Med. Chem. latest articlesCopyright (c) The Royal Society of ChemistryFri, 29 Mar 2024 04:31:17 ZRSC - RSC Med. Chem. latest articleshttp://pubs.rsc.org/content/NewImages/rsc_publishing_logo.gifRSC - RSC Med. Chem. latest articleshttp://pubs.rsc.org/en/Journals/Journal/MDhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00028Ehttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00028EA new class of 7-deazaguanine agents targeting autoimmune diseases: dramatic reduction of synovial fibroblast IL-6 production from human rheumatoid arthritis patients and improved performance against murine experimental autoimmune encephalomyelitis<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D4MD00028E" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D4MD00028E, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Michelle Cotter, Shauna M. Quinn, Ursula Fearon, Sharon Ansboro, Tatsiana Rakovic, John M. Southern, Vincent P. Kelly, Stephen J. Connon<br/>IL-6 production in treated human synovial fibroblasts from rheumatoid arthritis patients has been utilised to select candidates from a targeted library of queuine tRNA ribosyltransferase (QTRT) substrates for subsequent <em>in vivo</em> screening in murine experimental autoimmune encephalomyelitis.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-28T00:00:00ZMichelle CotterShauna M. QuinnUrsula FearonSharon AnsboroTatsiana RakovicJohn M. SouthernVincent P. KellyStephen J. Connonhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00136Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00136BDiscovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by synthetic methodology-based library<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00136B, Research Article</div><div>Tao Yu, Rong Zeng, Yu Guan, Bin Pan, Hong-Wei Li, Jing Gu, pengfei zheng, Yan Qian, Qin Ouyang<br/>The discovery of novel and highly effective P-gp inhibitors is considered to be an effective strategy for overcoming tumor drug resistance. In this paper, a phenotypic screening via self-constructed synthetic...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-27T00:00:00ZTao YuRong ZengYu GuanBin PanHong-Wei LiJing Gupengfei zhengYan QianQin Ouyanghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00123Khttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00123KLive cell screening to identify RNA-binding small molecule inhibitors of the pre-let-7–Lin28 RNA–protein interaction<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D4MD00123K" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D4MD00123K, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Sydney L. Rosenblum, Dalia M. Soueid, George Giambasu, Steve Vander Roest, Alexander Pasternak, Erin F. DiMauro, Vladimir Simov, Amanda L. Garner<br/>Dysregulation of the networking of RNA-binding proteins (RBPs) and RNAs drives many human diseases, including cancers, and the targeting of RNA–protein interactions (RPIs) has emerged as an exciting area of RNA-targeted drug discovery.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-19T00:00:00ZSydney L. RosenblumDalia M. SoueidGeorge GiambasuSteve Vander RoestAlexander PasternakErin F. DiMauroVladimir SimovAmanda L. Garnerhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00696Dhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00696DStructure-based virtual screening of unbiased and RNA-focused libraries to identify new ligands for the HCV IRES model system<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00696D" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00696D, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Elisabeth Kallert, Laura Almena Rodriguez, Jan-Åke Husmann, Kathrin Blatt, Christian Kersten<br/>Using structure-based virtual screening, FRET and MST assays, novel ligands of the hepatitis C virus internal ribosome entry site were identified. This proof-of-concept study demonstrated the feasibility of RNA–ligand docking for hit identification.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-18T00:00:00ZElisabeth KallertLaura Almena RodriguezJan-Åke HusmannKathrin BlattChristian Kerstenhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00063Chttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00063CDiscovery of novel SOS1 inhibitors using machine learning<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D4MD00063C" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D4MD00063C, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Lihui Duo, Yi Chen, Qiupei Liu, Zhangyi Ma, Amin Farjudian, Wan Yong Ho, Sze Shin Low, Jianfeng Ren, Jonathan D. Hirst, Hua Xie, Bencan Tang<br/>Machine learning enabled ligand-based virtual screening is a valuable tool in discovering effective SOS1 inhibitors.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-15T00:00:00ZLihui DuoYi ChenQiupei LiuZhangyi MaAmin FarjudianWan Yong HoSze Shin LowJianfeng RenJonathan D. HirstHua XieBencan Tanghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00101Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00101JBenzenesulfonamide Decorated Dihydropyrimidin(thi)ones: Carbonic Anhydrase Profiling and Antiproliferative Activity<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00101J, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Hakan Aslan, Gioele Renzi, Andrea Angeli, Ilaria D'Agostino, Roberto Ronca, Marialuisa Massardi, Camilla Tavani, Simone Carradori, Marta Ferraroni, Paolo Governa, Fabrizio Manetti, Fabrizio Carta, Claudiu Supuran<br/>In the last decades, Carbonic Anhydrases (CAs) have gone right to the top investigated innovative pharmacological targets and, in particular, isoforms IX and XII have been widely studied due to...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-26T00:00:00ZHakan AslanGioele RenziAndrea AngeliIlaria D'AgostinoRoberto RoncaMarialuisa MassardiCamilla TavaniSimone CarradoriMarta FerraroniPaolo GovernaFabrizio ManettiFabrizio CartaClaudiu Supuranhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00690Ehttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00690EInhibition of Bacterial RNA Polymerase Function and Protein-Protein Interactions: A Promising Approach for Next-Generation Antibacterial Therapeutics<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00690E, Review Article</div><div>Jiqing Ye, Cheuk Hei Kan, Xiao Yang, Cong Ma<br/>The increasing prevalence of multidrug-resistant pathogens necessitates the urgent development of new antimicrobial agents with innovative modes of action for the next generation of antimicrobial therapy. Bacterial transcription has been...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-26T00:00:00ZJiqing YeCheuk Hei KanXiao YangCong Mahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00003Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00003JPyrazolopyridine-based kinase inhibitors for anti-cancer targeted therapy<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00003J, Review Article</div><div>Pallabi Halder, Anubhav Rai, Vishal Talukdar, Parthasarathi Das, Naga Rajiv Lakkaniga<br/>The unmet medical need for the treatment of cancer continues to challenge the biomedical reearch community. The advent of targeted therapy significantly improved therapeutic outcomes. Drug discovery and development efforts...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-25T00:00:00ZPallabi HalderAnubhav RaiVishal TalukdarParthasarathi DasNaga Rajiv Lakkanigahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00058Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00058GAnti-cancer activity and mechanism of flurbiprofen organoselenium compound RY-1-92 in non-small cell lung cancer<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00058G, Research Article</div><div>Bo Cui, Xianda Cheng, Xin Zhang, Lili Chen, Wenqian Pang, Yue Liu, Zhe Yang, Hui Li, xianrna he, Xiaolong Li, Xiuli Bi<br/>Lung cancer is one of the malignancies with the highest incidence and mortality rates worldwide, and non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer types....<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-22T00:00:00ZBo CuiXianda ChengXin ZhangLili ChenWenqian PangYue Liu Zhe YangHui Lixianrna heXiaolong LiXiuli Bihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00060Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00060ACarltonine-Derived Compounds for Targeted Butyrylcholinesterase Inhibition<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00060A, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Filip Pidany, Jana Kroustkova, Jaroslav Jenco, Kateřina Breiterová, Lubica Muckova, Luci Novakova, Jiří Kuneš, Jakub Fibigar, Tomas Kucera, Martin Novak, Ales Sorf, Martina Hrabinova, Lenka Pulkrabkova, Jiri Janousek, Ondrej Soukup, Daniel Jun, Jan Korabecny, Lucie Cahlikova<br/>The investigation into human butyrylcholinesterase (hBChE) inhibitors as therapeutic agents for Alzheimer's disease (AD) holds significant promise, addressing both symptomatic relief and disease progression. In the pursuit of novel drug...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-22T00:00:00ZFilip PidanyJana KroustkovaJaroslav JencoKateřina BreiterováLubica MuckovaLuci NovakovaJiří KunešJakub FibigarTomas KuceraMartin NovakAles SorfMartina HrabinovaLenka PulkrabkovaJiri JanousekOndrej SoukupDaniel JunJan KorabecnyLucie Cahlikovahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00164Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00164HPhenythiazoles with Potent & Optimum Selectivity toward Clostridium Difficile<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00164H, Research Article</div><div>Mahmoud Magdy Seif El-Din, Mohamed Hagras, Abdelrahman Mayhoub <br/>Abstract Clostridium difficile (C. difficile) is one of the most threatening bacteria globally, causing high mortality and morbidity in humans and animals, and is considered a public health threat that...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-22T00:00:00ZMahmoud Magdy Seif El-DinMohamed HagrasAbdelrahman Mayhoub http://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00755Chttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00755CEnhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00755C" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00755C, Research Article</div><div>Keiji Nishiwaki, Shiori Nakatani, Shinya Nakamura, Kenji Yoshioka, Eri Nakagawa, Masato Tsuyuguchi, Takayoshi Kinoshita, Isao Nakanishi<br/>The design of the complex structure of CK2α and the inhibitor, leaving crystalline water molecules in the structure, significantly increased the inhibitory activity.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-12T00:00:00ZKeiji NishiwakiShiori NakataniShinya NakamuraKenji YoshiokaEri NakagawaMasato TsuyuguchiTakayoshi KinoshitaIsao Nakanishihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00093Ehttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00093EIdentification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00093E, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Edward A FitzGerald, Daniela Cederfelt, Bjarte A. Lund, Nadine Myers, He Zhang, Doreen Dobritzsch, Helena Danielson<br/>A 1056-membered fragment library has been screened against SMYD3 using a novel multiplexed experimental design implemented in a grating coupled interferometry (GCI) based biosensor. SMYD3 is a prospective target for...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-20T00:00:00ZEdward A FitzGeraldDaniela CederfeltBjarte A. LundNadine MyersHe ZhangDoreen DobritzschHelena Danielsonhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00110Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00110AHelical Sulfonyl-γ-AApeptides in the Inhibition of HIV-1 Fusion and HIF-1α Signaling<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00110A, Review Article</div><div>Xue Zhao, Heng Liu, Justin Zhang, Jianfeng Cai<br/>Unnatural helical peptidic foldamers show promising applications in chemical biology and biomedical sciences by mimicking protein helical segments. Sulfonyl-γ-AApeptide helices developed by our group exhibit good chemodiversity, predictable folding structures,...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-20T00:00:00ZXue ZhaoHeng LiuJustin ZhangJianfeng Caihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00061Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00061GExploiting thiol-functionalized benzosiloxaboroles for achieving diverse substitution patterns – synthesis, characterization and biological evaluation of promising antibacterial agents<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00061G, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Krzysztof Nowicki, Joanna Krajewska, Tomasz Stępniewski, Monika Wielechowska, Patrycja Wińska, Anna Kaczmarczyk, Julia Korpowska, Jana Selent, Paulina H. Marek-Urban, Krzysztof Durka, Krzysztof Wozniak, Agnieszka E. Laudy, Sergiusz Luliński<br/>Benzosiloxaboroles are emerging class of medicinal agents possessing promising antimicrobial activity. Herein, the expedient synthesis of two novel thiol-functionalized benzosiloxaboroles 1e and 2e is reported. The presence of SH group...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-20T00:00:00ZKrzysztof NowickiJoanna KrajewskaTomasz StępniewskiMonika WielechowskaPatrycja WińskaAnna KaczmarczykJulia KorpowskaJana SelentPaulina H. Marek-UrbanKrzysztof DurkaKrzysztof WozniakAgnieszka E. LaudySergiusz Lulińskihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00031Ehttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00031EDesign, synthesis and antibacterial activity evaluation of ebselen derivatives in NDM-1 producing bacteria<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00031E, Research Article</div><div>Wanli Meng, Chenyu Liu, Guangxing Wu, Zhongyue Bai, Zhihao Wang, Sheng Chen, Shengbiao Wan, Wandong Liu<br/>New Delhi-β-lactamase-1 (NDM-1) is a type of one of metal-β-lactamase. NDM-1-expressing bacteria can spread rapidly across the globe via plasmid transfer, which greatly undermines the clinical efficacy of the last...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-20T00:00:00ZWanli MengChenyu LiuGuangxing WuZhongyue BaiZhihao WangSheng ChenShengbiao WanWandong Liuhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00633Fhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00633FChemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00633F" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,1066-1071<br/><b>DOI</b>: 10.1039/D3MD00633F, Research Article</div><div>Aliakbar Khalili Yazdi, Sumera Perveen, Cheng Dong, Xiaosheng Song, Aiping Dong, Magdalena M. Szewczyk, Matthew F. Calabrese, Agustin Casimiro-Garcia, Subramanyam Chakrapani, Matthew S. Dowling, Emel Ficici, Jisun Lee, Justin I. Montgomery, Thomas N. O'Connell, Grzegorz J. Skrzypek, Tuan P. Tran, Matthew D. Troutman, Feng Wang, Jennifer A. Young, Jinrong Min, Dalia Barsyte-Lovejoy, Peter J. Brown, Vijayaratnam Santhakumar, Cheryl H. Arrowsmith, Masoud Vedadi, Dafydd R. Owen<br/>A chemical probe (PFI-7) for the Gid4 subunit of the human E3 ligase CTLH degradation complex.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-05T00:00:00ZAliakbar Khalili YazdiSumera PerveenCheng DongXiaosheng SongAiping DongMagdalena M. SzewczykMatthew F. CalabreseAgustin Casimiro-GarciaSubramanyam ChakrapaniMatthew S. DowlingEmel FiciciJisun LeeJustin I. MontgomeryThomas N. O'ConnellGrzegorz J. SkrzypekTuan P. TranMatthew D. TroutmanFeng WangJennifer A. YoungJinrong MinDalia Barsyte-LovejoyPeter J. BrownVijayaratnam SanthakumarCheryl H. ArrowsmithMasoud VedadiDafydd R. Owenhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00017Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00017JSynthesis and structure–activity relationship of novel thiazole aminoguanidines against MRSA and Escherichia coli<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D4MD00017J" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,1003-1014<br/><b>DOI</b>: 10.1039/D4MD00017J, Research Article</div><div>Ping Yang, Hui-Zhong Liu, Ying-Si Wang, Hong Qi, Ling-Ling Wang, Bei-Bei Wang, Xiao-Bao Xie<br/>Increasing molecular flexibility improves the performance of thiazole aminoguanidines against drug-resistant bacteria and Gram-negative bacteria.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-29T00:00:00ZPing YangHui-Zhong LiuYing-Si WangHong QiLing-Ling WangBei-Bei WangXiao-Bao Xiehttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00674Chttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00674CThe medicinal chemistry evolution of antibody–drug conjugates<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00674C" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,809-831<br/><b>DOI</b>: 10.1039/D3MD00674C, Review Article</div><div>Adrian D. Hobson<br/>For an optimal ADC the symbiotic relationship of the three structurally disparate components requires they all function in unison and medicinal chemistry has a huge role to enable this.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-28T00:00:00ZAdrian D. Hobsonhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00027Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00027GRecognition of arylmethylidene derivatives of imidazothiazolotriazinones as novel tubulin polymerization inhibitors<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D4MD00027G" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D4MD00027G, Research Article</div><div>Alexei N. Izmest'ev, Elena V. Svirshchevskaya, Sergey B. Akopov, Angelina N. Kravchenko, Galina A. Gazieva<br/>Twelve compounds (<strong>2e</strong>, <strong>2f</strong>, <strong>2j</strong>, <strong>2k</strong>, and <strong>2m–2t</strong>) with GI<small><sub>50</sub></small> values against cancer cells in the nanomolar range were found. Compound <strong>2n</strong> blocked tubilin polymerization in the same way as colchicine and induced arrest at the G2/M phase of the cell cycle.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-28T00:00:00ZAlexei N. Izmest'evElena V. SvirshchevskayaSergey B. AkopovAngelina N. KravchenkoGalina A. Gazievahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD90009Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD90009JCorrection: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody–drug conjugate properties<div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,1072-1072<br/><b>DOI</b>: 10.1039/D4MD90009J, Correction</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Adrian D. Hobson, Haizhong Zhu, Wei Qiu, Russell A. Judge, Kenton Longenecker<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-22T00:00:00ZAdrian D. HobsonHaizhong ZhuWei QiuRussell A. JudgeKenton Longeneckerhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00043Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00043ASynthesis and bioactivity of psilocybin analogues containing a stable carbon–phosphorus bond<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D4MD00043A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,998-1002<br/><b>DOI</b>: 10.1039/D4MD00043A, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Marthe Vandevelde, Andreas Simoens, Bavo Vandekerckhove, Christian Stevens<br/>Psilocybin analogues have been synthesized comprising a non-hydrolysable P–C bond to evaluate the biological activity and the selectivity towards 5-HT<small><sub>2A</sub></small>R, 5-HT<small><sub>2B</sub></small>R and the TNAP receptor.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-21T00:00:00ZMarthe VandeveldeAndreas SimoensBavo VandekerckhoveChristian Stevenshttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00601Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00601HUnusual Ni⋯Ni interaction in Ni(II) complexes as potential inhibitors for the development of new anti-SARS-CoV-2 Omicron drugs<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00601H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,895-915<br/><b>DOI</b>: 10.1039/D3MD00601H, Research Article</div><div>Simranjeet Singh, Mukesh Choudhary<br/>In this study, two nickel(<small>II</small>) coordination complexes [Ni(L)]<small><sub>2</sub></small>(<strong>1</strong>) and [Ni(L)]<small><sub><em>n</em></sub></small>(<strong>2</strong>) of a tetradentate-N<small><sub>2</sub></small>O<small><sub>2</sub></small> donor Schiff base ligand (<strong>H</strong><small><sub><strong>2</strong></sub></small><strong>L</strong>) were synthesized, designed and characterized via spectroscopic and SC-XRD analysis, and molecular docking study.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-20T00:00:00ZSimranjeet SinghMukesh Choudharyhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00708Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00708ADesign, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00708A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,963-980<br/><b>DOI</b>: 10.1039/D3MD00708A, Research Article</div><div>Mihaela-Liliana Ţînţaş, Ludovic Peauger, Anaïs Barré, Cyril Papamicaël, Thierry Besson, Jana Sopkovà-de Oliveira Santos, Vincent Gembus, Vincent Levacher<br/>Promising multitargets ligands in Alzheimer's disease: sequential BuChE and DYRK1A/CLK1 kinases inhibition.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-20T00:00:00ZMihaela-Liliana ŢînţaşLudovic PeaugerAnaïs BarréCyril PapamicaëlThierry BessonJana Sopkovà-de Oliveira SantosVincent GembusVincent Levacherhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00645Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00645JIn vitro biological evaluation and in silico studies of linear diarylheptanoids from Curcuma aromatica Salisb. as urease inhibitors<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00645J" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,1046-1054<br/><b>DOI</b>: 10.1039/D3MD00645J, Research Article</div><div>Tho Huu Le, Dung Ngoc Phuong Ho, Hai Xuan Nguyen, Truong Nhat Van Do, Mai Thanh Thi Nguyen, Lam K. Huynh, Nhan Trung Nguyen<br/>This study reports nine new diarylheptanoids first isolated from the <em>Curcuma aromatica</em> Salisb., among which three are discovered for the first time, and two significantly inhibit urease, shedding light on its potential in treating gastric ulcers.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-16T00:00:00ZTho Huu LeDung Ngoc Phuong HoHai Xuan NguyenTruong Nhat Van DoMai Thanh Thi NguyenLam K. HuynhNhan Trung Nguyenhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00602Fhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00602FApplication of tobramycin benzyl ether as an antibiotic adjuvant capable of sensitizing multidrug-resistant Gram-negative bacteria to rifampicin<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00602F" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,1055-1065<br/><b>DOI</b>: 10.1039/D3MD00602F, Research Article</div><div>Danzel Marie Ramirez, Shiv Dhiman, Ayan Mukherjee, Ruwani Wimalasekara, Frank Schweizer<br/>The emergence of aminoglycoside resistance has prompted the development of amphiphilic aminoglycoside derivatives which target bacterial membranes.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-16T00:00:00ZDanzel Marie RamirezShiv DhimanAyan MukherjeeRuwani WimalasekaraFrank Schweizerhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00719Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00719GDeconvoluting low yield from weak potency in direct-to-biology workflows with machine learning<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00719G" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,1015-1021<br/><b>DOI</b>: 10.1039/D3MD00719G, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>William McCorkindale, Mihajlo Filep, Nir London, Alpha A. Lee, Emma King-Smith<br/>Augmenting direct-to-biology workflows with a new machine learning framework.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-15T00:00:00ZWilliam McCorkindaleMihajlo FilepNir LondonAlpha A. LeeEmma King-Smithhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00619Khttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00619KDesign, synthesis and biological evaluation of rhein–piperazine–furanone hybrids as potential anticancer agents<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00619K" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,848-855<br/><b>DOI</b>: 10.1039/D3MD00619K, Research Article</div><div>Yu He, Si-Si Zhang, Meng-Xue Wei<br/>Novel rhein–piperazine–furanone hybrids, <strong>5</strong>, were designed and synthesized efficiently. Hybrid <strong>5e</strong>, the most potent compound, was 46- and 35-fold more toxic to human lung cancer A549 cells than rhein and the reference cytarabine (CAR), respectively.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-13T00:00:00ZYu HeSi-Si ZhangMeng-Xue Weihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00665Dhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00665DStereoselective synthesis and antiproliferative activity of allo-gibberic acid-based 1,3-aminoalcohol regioisomers<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00665D" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,874-887<br/><b>DOI</b>: 10.1039/D3MD00665D, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Zein Alabdeen Khdar, Tam Minh Le, Zsuzsanna Schelz, István Zupkó, Zsolt Szakonyi<br/>Starting from gibberellic acid (GA3), a library of <em>allo</em>-gibberic acid-based aminoalcohols was synthesised, and their antiproliferative effects were assayed by <em>in vitro</em> MTT method against a panel of human cancer cell lines (HeLa, SiHa, A2780, MCF-7, MDA-MB-231).<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-12T00:00:00ZZein Alabdeen KhdarTam Minh LeZsuzsanna SchelzIstván ZupkóZsolt Szakonyihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00604Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00604BDiscovery of a new pyrido[2,3-d]pyridazine-2,8-dione derivative as a potential anti-inflammatory agent through COX-1/COX-2 dual inhibition<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00604B" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,1038-1045<br/><b>DOI</b>: 10.1039/D3MD00604B, Research Article</div><div>Fernanda A. Rosa, Davana S. Gonçalves, Karlos E. Pianoski, Michael J. V. da Silva, Franciele Q. Ames, Rafael P. Aguiar, Hélito Volpato, Danielle Lazarin-Bidóia, Celso V. Nakamura, Ciomar A. Bersani-Amado<br/>The new pyrido[2,3-<em>d</em>]pyridazine-2,8-dione <strong>7c</strong> showed potential anti-inflammatory activity as a COX-1/COX-2 dual inhibitor.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-08T00:00:00ZFernanda A. RosaDavana S. GonçalvesKarlos E. PianoskiMichael J. V. da SilvaFranciele Q. AmesRafael P. AguiarHélito VolpatoDanielle Lazarin-BidóiaCelso V. NakamuraCiomar A. Bersani-Amadohttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00751Khttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00751KDesign and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00751K" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,981-997<br/><b>DOI</b>: 10.1039/D3MD00751K, Research Article</div><div>Norhan A. Abdelrahman, Ahmed A. Al-Karmalawy, Maiy Y. Jaballah, Galal Yahya, Marwa Sharaky, Khaled A. M. Abouzid<br/>Novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-06T00:00:00ZNorhan A. AbdelrahmanAhmed A. Al-KarmalawyMaiy Y. JaballahGalal YahyaMarwa SharakyKhaled A. M. Abouzidhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00490Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00490BReinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00490B" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,1022-1037<br/><b>DOI</b>: 10.1039/D3MD00490B, Research Article</div><div>Hari Madhav, G. Srinivas Reddy, Zeba Rizvi, Ehtesham Jameel, Tarosh S. Patel, Abdur Rahman, Vikas Yadav, Sadaf Fatima, Fatima Heyat, Kavita Pal, Amisha Minju-OP, Naidu Subbarao, Souvik Bhattacharjee, Bharat C. Dixit, Puran Singh Sijwali, Nasimul Hoda<br/>The present study unveils a thorough reevaluation of diphenylmethylpiperazine and pyrazine-derived molecular hybrids, introducing them as a new class of antimalarials.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-01T00:00:00ZHari MadhavG. Srinivas ReddyZeba RizviEhtesham JameelTarosh S. PatelAbdur RahmanVikas YadavSadaf FatimaFatima HeyatKavita PalAmisha Minju-OPNaidu SubbaraoSouvik BhattacharjeeBharat C. DixitPuran Singh SijwaliNasimul Hodahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00714Fhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00714FInhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00714F" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,916-936<br/><b>DOI</b>: 10.1039/D3MD00714F, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Anjie S. Bispat, Fernanda C. Cardoso, Md. Mahadhi Hasan, Yashad Dongol, Ricki Wilcox, Richard J. Lewis, Peter J. Duggan, Kellie L. Tuck<br/>A detailed SAR study led to two potent Ca<small><sub>V</sub></small>2.2 inhibitors, the sulfonamide derivatives 42 and 45, which showed high plasma stability, low toxicity, favourable CNS MPO scores (4.0–4.4), and strong potency.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-31T00:00:00ZAnjie S. BispatFernanda C. CardosoMd. Mahadhi HasanYashad DongolRicki WilcoxRichard J. LewisPeter J. DugganKellie L. Tuckhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00663Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00663HDiscovery of benzoheterocyclic-substituted amide derivatives as apoptosis signal-regulating kinase 1 (ASK1) inhibitors<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00663H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,856-873<br/><b>DOI</b>: 10.1039/D3MD00663H, Research Article</div><div>Lin Tang, Minxiong Li, Changlin Bai, Xuejin Feng, Haiyang Hu, Yufen Yao, Baiqing Li, Hongwei Li, Guohong Qin, Ning Xi, Genpin Lv, Lei Zhang<br/>Three series of benzoheterocyclic-substituted amide derivatives were designed and synthesized in this work, and compound <strong>17a</strong> was discovered to be a novel potent inhibitor of ASK1 with good druggability.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-30T00:00:00ZLin TangMinxiong LiChanglin BaiXuejin FengHaiyang HuYufen YaoBaiqing LiHongwei LiGuohong QinNing XiGenpin LvLei Zhanghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00648Dhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00648DMolecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00648D" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,937-962<br/><b>DOI</b>: 10.1039/D3MD00648D, Research Article</div><div>Vajja Krishna Rao, Subarno Paul, Mitchell Gulkis, Zhihang Shen, Haritha Nair, Amandeep Singh, Chenglong Li, Arun K. Sharma, Melike Çağlayan, Chinmay Das, Biswajit Das, Chanakya N. Kundu, Satya Narayan, Sankar K. Guchhait<br/>In this study, a unique strategy of scaffold-hopping-based molecular editing of a bioactive agent <strong>NSC-666719</strong> was investigated, which led to the development of new benzodithiazinedioxide-guanidine based anticancer agents with Polβ inhibition.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-30T00:00:00ZVajja Krishna RaoSubarno PaulMitchell GulkisZhihang ShenHaritha NairAmandeep SinghChenglong LiArun K. SharmaMelike ÇağlayanChinmay DasBiswajit DasChanakya N. KunduSatya NarayanSankar K. Guchhaithttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00677Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00677HIndole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00677H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,788-808<br/><b>DOI</b>: 10.1039/D3MD00677H, Review Article</div><div>Wei Zeng, Chi Han, Sarah Mohammed, Shanshan Li, Yixuan Song, Fengxia Sun, Yunfei Du<br/>Over the past few decades indole derived drugs has gained great attention from medicinal chemists. This review provides an overview of all marked drugs containing the indole scaffold and their targets, pharmacological activities and SAR studies.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-30T00:00:00ZWei ZengChi HanSarah MohammedShanshan LiYixuan SongFengxia SunYunfei Duhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00587Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00587ACytochrome bd oxidase: an emerging anti-tubercular drug target<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00587A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,769-787<br/><b>DOI</b>: 10.1039/D3MD00587A, Review Article</div><div>Pallavi Saha, Samarpita Das, Harish K. Indurthi, Rohit Kumar, Arnab Roy, Nitin Pal Kalia, Deepak K. Sharma<br/>Cytochrome bd (cyt-<em>bd</em>) oxidase, one of the two terminal oxidases in the <em>Mycobacterium tuberculosis</em> (<em>Mtb</em>) oxidative phosphorylation pathway, plays an indispensable role in maintaining the functionality of the metabolic pathway under stressful conditions.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-27T00:00:00ZPallavi SahaSamarpita DasHarish K. IndurthiRohit KumarArnab RoyNitin Pal KaliaDeepak K. Sharmahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00737Ehttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00737EN-Arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00737E" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,839-847<br/><b>DOI</b>: 10.1039/D3MD00737E, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Rostom Ahmed-Belkacem, Joris Troussier, Adrien Delpal, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart<br/>SAH-derived bisubstrates of SARS-CoV-2 cap RNA <em>N</em>7-methyltransferase were synthesized, and two adenosines with an <em>N</em>-arylsulfonamide core attached by an <em>N</em>-ethylthioether linker proved to be effective inhibitors in the submicromolar range.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-26T00:00:00ZRostom Ahmed-BelkacemJoris TroussierAdrien DelpalBruno CanardJean-Jacques VasseurEtienne DecrolyFrançoise Debarthttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00529Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00529ADevelopment of Hsp90 C-terminal inhibitors with noviomimetics that manifest anti-proliferative activities<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00529A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,888-894<br/><b>DOI</b>: 10.1039/D3MD00529A, Research Article</div><div>Eva Amatya, Chitra Subramanian, Mark S. Cohen, Brian S. J. Blagg<br/>Inhibition of the Hsp90 C-terminal domain offers a promising opportunity to treat numerous diseases/indications.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-18T00:00:00ZEva AmatyaChitra SubramanianMark S. CohenBrian S. J. Blagghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00540Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00540BMinimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00540B" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,832-838<br/><b>DOI</b>: 10.1039/D3MD00540B, Research Article</div><div>Adrian D. Hobson, Haizhong Zhu, Wei Qiu, Russell A. Judge, Kenton Longenecker<br/>Minimising solvent exposed hydrophobic surface area of payload is identified as a critical design parameter for optimising ADC drug-like properties.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-09T00:00:00ZAdrian D. HobsonHaizhong ZhuWei QiuRussell A. JudgeKenton Longeneckerhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00366Chttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00366CSETDB1 as a cancer target: Challenges and perspectives in drug design<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00366C, Review Article</div><div>Haifa Hassanie, André Berndt Penteado, Larissa Costa de Almeida, Raisa Calil, Flavio da Silva Emery, Leticia Veras Costa-Lotufo, Gustavo Trossini<br/>Genome stability is governed by chromatin structural dynamics, which modify DNA accessibility under the influence of intra- and inter-nucleosomal contacts, histone post-translational modifications (PTMs) and variations, besides the activity of...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-19T00:00:00ZHaifa HassanieAndré Berndt PenteadoLarissa Costa de AlmeidaRaisa CalilFlavio da Silva EmeryLeticia Veras Costa-LotufoGustavo Trossinihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00062Ehttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00062ESynthesis and biological evaluation of new naphthalimide–thiourea derivatives as potent antimicrobial agents active against multidrug-resistant Staphylococcus aureus and Mycobacterium tuberculosis<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D4MD00062E" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D4MD00062E, Research Article</div><div>Preeti Rana, Ramulu Parupalli, Abdul Akhir, Deepanshi Saxena, Rahul Maitra, Mohmmad Imran, Pradip Malik, Shaik Mahammad Ghouse, Swanand Vinayak Joshi, Danaboina Srikanth, Y. V. Madhavi, Arunava Dasgupta, Sidharth Chopra, Srinivas Nanduri<br/>Novel series of naphthalimide thiourea derivatives were synthesised and evaluated against bacterial pathogen panel and mycobacterial pathogen panel.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-19T00:00:00ZPreeti RanaRamulu ParupalliAbdul AkhirDeepanshi SaxenaRahul MaitraMohmmad ImranPradip MalikShaik Mahammad GhouseSwanand Vinayak JoshiDanaboina SrikanthY. V. MadhaviArunava DasguptaSidharth ChopraSrinivas Nandurihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00736Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00736GEbselen analogues with dual human neutrophil elastase (HNE) inhibitory and antiradical activity<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00736G" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00736G, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Letizia Crocetti, Francesca Catarzi, Maria Paola Giovannoni, Claudia Vergelli, Gianluca Bartolucci, Marco Pallecchi, Paola Paoli, Patrizia Rossi, Martina Lippi, Igor A. Schepetkin, Mark T. Quinn, Gabriella Guerrini<br/>HNE inhibitors with antiradical properties may be therapeutically beneficial for the treatment of respiratory diseases involving inflammation and oxidative stress.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-19T00:00:00ZLetizia CrocettiFrancesca CatarziMaria Paola GiovannoniClaudia VergelliGianluca BartolucciMarco PallecchiPaola PaoliPatrizia RossiMartina LippiIgor A. SchepetkinMark T. QuinnGabriella Guerrinihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00682Dhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00682DIn vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therapeutic agents for triple negative breast cancer<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00682D" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00682D, Research Article</div><div>Luísa Carvalho, Fábio Pedroso de Lima, Mónica Cerqueira, Ana Silva, Olívia Pontes, Sofia Oliveira-Pinto, Sara Guerreiro, Marta D. Costa, Sara Granja, Patrícia Maciel, Adhemar Longatto-Filho, Fátima Baltazar, Fernanda Proença, Marta Costa<br/>Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the limited therapeutic options show poor efficacy in patients, associated to severe side effects and development of resistance.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-19T00:00:00ZLuísa CarvalhoFábio Pedroso de LimaMónica CerqueiraAna SilvaOlívia PontesSofia Oliveira-PintoSara GuerreiroMarta D. CostaSara GranjaPatrícia MacielAdhemar Longatto-FilhoFátima BaltazarFernanda ProençaMarta Costahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00668Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00668ACoumarin–furo[2,3-d]pyrimidone hybrid molecules targeting human liver cancer cells: Synthesis, anticancer effect, EGFR inhibition and molecular docking studies<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00668A, Research Article</div><div>Tianshuai Wang, Yumeng Gao, Fengxu Wu, Lun Luo, Junkai Ma, Yanggen Hu<br/>The design, synthesis and investigation of antitumor activities of some coumarin–furo[2,3-d]pyrimidone hybrid molecules are reported. In vitro, HepG2 cells were used to investigate the cytotoxicity of 6a-n and 10a-n. The results demonstrated...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-19T00:00:00ZTianshuai WangYumeng GaoFengxu WuLun LuoJunkai MaYanggen Huhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00021Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00021HNew azole derivatives linked to indole/indoline moieties combined with FLC against drug-resistant Candida albicans<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D4MD00021H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D4MD00021H, Research Article</div><div>Yunhong Shen, Min Pan, Hui Gao, Yi Zhang, Ruirui Wang, Jun Li, Zewei Mao<br/>A series of novel azole derivatives linked to indole/indoline moieties were prepared. If combined with FLC, they had high activity against drug-resistant <em>Candida albicans in vitro</em>.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-28T00:00:00ZYunhong ShenMin PanHui GaoYi ZhangRuirui WangJun LiZewei Maohttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00655Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00655GProgress in small-molecule inhibitors targeting PD-L1<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00655G" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00655G, Review Article</div><div>Jindan Xu, Yuanfang Kong, Pengbo Zhu, Mingyan Du, Xuan Liang, Yan Tong, Xiaofei Li, Chunhong Dong<br/>The feature of the PD-L1 protein and the basic backbone of PD-L1 small-molecule inhibitors have been summarized, it is an important guidance for researchers to develop PD-L1 small molecule inhibitors based on protein characteristic.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-04T00:00:00ZJindan XuYuanfang KongPengbo ZhuMingyan DuXuan LiangYan TongXiaofei LiChunhong Donghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00711Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00711ANitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00711A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00711A, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Joana R. L. Ribeiro, Nikoletta Szemerédi, Bruno M. F. Gonçalves, Gabriella Spengler, Carlos A. M. Afonso, Maria-José U. Ferreira<br/>A set of twenty-three new andrographolide derivatives, bearing a nitrogen-containing moiety, is reported. Several derivatives were found to be promising leads for reversing cancer multidrug resistance.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-26T00:00:00ZJoana R. L. RibeiroNikoletta SzemerédiBruno M. F. GonçalvesGabriella SpenglerCarlos A. M. AfonsoMaria-José U. Ferreirahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00744Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00744HA novel BODIPY-based theranostic agent for in vivo fluorescence imaging of cerebral Aβ and ameliorating Aβ-associated disorders in Alzheimer's disease transgenic mice<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00744H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00744H, Research Article</div><div>Jingjing Zhang, Wenming Ren, Xiaohui Liu, Jingjing Chen, Yuteng Zeng, Huaijiang Xiang, Youhong Hu, Haiyan Zhang<br/>We report the synthesis, characteristics, and biological evaluations of a novel theranostic agent, <strong>P14</strong>, for both <em>in vitro</em> and <em>in vivo</em> imaging of central Aβ plaques, inhibition of Aβ aggregation, and neuronal damage as well as behavioral deficits.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-15T00:00:00ZJingjing ZhangWenming RenXiaohui LiuJingjing ChenYuteng ZengHuaijiang XiangYouhong HuHaiyan Zhanghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00730Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00730HDesign, synthesis, in vitro and in silico evaluation of indole-based tetrazole derivatives as putative anti-breast cancer agents<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00730H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00730H, Research Article</div><div>Kamalpreet Kaur, Harkomal Verma, Prabhakar Gangwar, Monisha Dhiman, Vikas Jaitak<br/>Design, synthesis, and <em>in vitro</em> and <em>in silico</em> evaluation of indole-based tetrazole derivatives as putative anti-breast cancer agents.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-19T00:00:00ZKamalpreet KaurHarkomal VermaPrabhakar GangwarMonisha DhimanVikas Jaitakhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00628Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00628JScreening of efficient salicylaldoxime reactivators for DFP and paraoxon-inhibited acetylcholinesterase<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00628J" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00628J, Research Article</div><div>Zhao Wei, Dongxu Zhang, Xueying Liu, Huifang Nie, Qin Ouyang, Xinlei Zhang, Zhibing Zheng<br/>Dual-site binding mode of lead compounds with AChE and construction of novel salicylaldoxime reactivators using a fragment-based drug design strategy.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-30T00:00:00ZZhao WeiDongxu ZhangXueying LiuHuifang NieQin OuyangXinlei ZhangZhibing Zhenghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00038Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00038BDesign, synthesis, and evaluation of novel ferrostatin derivatives for the prevention of HG-induced VEC ferroptosis<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D4MD00038B" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D4MD00038B, Research Article</div><div>Xin-Xin Wang, Run-Jie Wang, Hua-Long Ji, Xiao-Yu Liu, Nai-Yu Zhang, Kai-Ming Wang, Kai Chen, Ping-Ping Liu, Ning Meng, Cheng-Shi Jiang<br/>This work designed and synthesized novel ferrostatin analogs with a benzohydrazide moiety, and identified compound <strong>12</strong> as a promising lead for preventing HG-induced VEC ferroptosis.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-28T00:00:00ZXin-Xin WangRun-Jie WangHua-Long JiXiao-Yu LiuNai-Yu ZhangKai-Ming WangKai ChenPing-Ping LiuNing MengCheng-Shi Jianghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00746Dhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00746D1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00746D" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00746D, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Robin van der Straat, Rosalie Draijer, Ewa Surmiak, Roberto Butera, Lennart Land, Katarzyna Magiera-Mularz, Bogdan Musielak, Jacek Plewka, Tad A. Holak, Alexander Dömling<br/>Utilizing a combination of structure-based design, MCR synthesis, biophysics, and protein crystallography to innovate a novel tetrazole scaffold targeting the PD-1/PD-L1 immune checkpoint protein complex.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-21T00:00:00ZRobin van der StraatRosalie DraijerEwa SurmiakRoberto ButeraLennart LandKatarzyna Magiera-MularzBogdan MusielakJacek PlewkaTad A. HolakAlexander Dömlinghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00718Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00718AImidazopyrimidine: From relatively exotic scaffold to evolving structural motif in drug discovery<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00718A, Review Article</div><div>MOUMITA GHOSH CHOWDHURY, Vaishnavi Kalmegh, Saumya Kapoor, Vaishnavi Kamble, Amit Shard<br/>Nitrogen-fused heterocycles are of immense importance in modern drug discovery and development. Among them, imidazopyrimidine is a highly versatile scaffold with vast pharmacological utility. These compounds demonstrate a broad spectrum...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-13T00:00:00ZMOUMITA GHOSH CHOWDHURYVaishnavi KalmeghSaumya KapoorVaishnavi KambleAmit Shardhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00086Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00086BDesign, synthesis and antimycobacterial activity of Imidazo[1,5-a]quinolines and their Zinc-complexes<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00086B, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Michael Marner, Niclas Kulhanek, Johanna Eichberg, Kornelia Hardes, Michael Dal-Molin, Jan Rybniker, Michael Kirchner, Till Schäberle, Richard Goettlich<br/>Tuberculosis remains to be one of the worlds deadliest infectious deseases. Complexity and numerous adversive effects of current treatment options as well as the emergence of multi-drug resistant M. tuberculosis...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-12T00:00:00ZMichael MarnerNiclas KulhanekJohanna EichbergKornelia HardesMichael Dal-MolinJan RybnikerMichael KirchnerTill SchäberleRichard Goettlichhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00686Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00686G4-Trifluormethyl Bithiazoles as Broad-Spectrum Antimicrobial Agents for Virus-Related Bacterial Infections or co-Infections<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00686G, Research Article</div><div>Francesca Barbieri, Vincent Carlen, Maria Grazia Martina, Filomena Sannio, Sacha Cancade, Cecilia Perini, Margherita Restori, Emmanuele Crespan, Giovanni Maga, Jean-Denis Docquier, Valeria Cagno, Marco Radi<br/>Respiratory tract infections, involving a variety of microorganisms such as viruses, bacteria, and fungi, are a prominent cause of morbidity and mortality globally, exacerbating various pre-existing respiratory and non-respiratory conditions....<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-12T00:00:00ZFrancesca BarbieriVincent CarlenMaria Grazia MartinaFilomena SannioSacha CancadeCecilia PeriniMargherita RestoriEmmanuele CrespanGiovanni MagaJean-Denis DocquierValeria CagnoMarco Radihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00015Chttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00015CDesign and Synthesis of Meldrum’s acid Based 7-Azaindole Anchored 1,2,3-Triazole Hybrids as Anticancer Agents<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00015C, Research Article</div><div>Muralikrishna Vanga, Rambabu Bhukya, Vishnu Thumma, S S S S Sudha Ambadipudi, Lakshma V. Nayak, SAI BALAJI ANDUGULAPATI, vijjulatha manga<br/>A series of Meldrum’s acid, 7-azaindole and 1,2,3-triazole hybrids were synthesized and evaluated for their anticancer activity in five different cancer cell lines i.e.: MCF-7 (breast cancer), HeLa (cervical cancer),...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-11T00:00:00ZMuralikrishna VangaRambabu BhukyaVishnu ThummaS S S S Sudha AmbadipudiLakshma V. NayakSAI BALAJI ANDUGULAPATIvijjulatha mangahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00752Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00752AAptamer AS411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00752A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00752A, Research Article</div><div>Yuejie Zhu, Xiang Li, Qi Zhang, Xiantao Yang, Xudong Sun, Yi Pan, Xia Yuan, Yuan Ma, Bo Xu, Zhenjun Yang<br/>Encapsulated by cytidinyl lipid, G-quadruplex based aptamer AS1411 <em>etc.</em> entered nucleus and targeted to KRAS promoter/hnRNP A1 complex, showed higher activity against drug-resistant lung cancer.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-04T00:00:00ZYuejie ZhuXiang LiQi ZhangXiantao YangXudong SunYi PanXia YuanYuan MaBo XuZhenjun Yanghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00600Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00600J2,3-Dihydroquinazolin-4(1H)-ones and Quinazolin-4(3H)-ones as Broad-Spectrum Cytotoxic Agents and Impact on Tubulin Polymerisation<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00600J, Research Article</div><div>Nicholas O'Brien, Jayne Gilbert, Adam McCluskey, Jennette Sakoff<br/>Tubulin plays a central role in mitosis and has been the target of multiple anticancer drugs, including paclitaxel. Herein two separate families of 2,3-dihydroquinazoline-4(1<em>H</em>)-ones and quinazoline-4(3<em>H</em>) ones, comprising 57 compounds...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-06T00:00:00ZNicholas O'BrienJayne GilbertAdam McCluskeyJennette Sakoff