RSC - Lab Chip latest articles

Engineering and Analysis of Surface Interactions in a Microfluidic Herringbone Micromixer

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40356K, Technical Innovation

Thomas P Forbes, Jason Kralj
We developed a computational model and theoretical framework to investigate the geometrical optimization of particle-surface interactions in a herringbone micromixer. The enhancement of biomolecule- and particle-surface interactions in microfluidic devices...
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Engineering the surface properties of microfluidic stickers

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40284J, Technical Innovation

Bertrand Levache, Ammar Azioune, Maurice Bourrel, Vincent Studer, Denis Bartolo
We introduce a simple and effective method to tailor the wetting, and the adhesion, properties of microfluidic stickers. This one-step lithographic scheme combines most of the advantages offered by the...
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Ultra-rapid laser protein micropatterning: screening for directed polarization of single neurons

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21105J, Paper

Mark A. Scott, Zachary D. Wissner-Gross, Mehmet Fatih Yanik
We present a rapid laser protein-micropatterning method using multi-photon photobleaching of fluorophores, and direct the polarization of single neurons using triangle ratchets.
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Integrated rapid-diagnostic-test reader platform on a cellphone

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40235A, Paper

Onur Mudanyali, Stoyan Dimitrov, Uzair Sikora, Swati Padmanabhan, Isa Navruz, Aydogan Ozcan
We demonstrate a cellphone-based rapid-diagnostic-test reader platform that can work with various types of lateral flow immuno-chromatographic assay to sense the presence of a target analyte in a sample.
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Recent progress in the design of nanofiber-based biosensing devices

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21240D, Critical Review

Lauren Matlock-Colangelo, Antje J. Baeumner
This review discusses the nanofiber materials used to increase functional surface area and improve sensitivity of analyte detection within biosensors.
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Ion diode logics for pH control

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40093F, Paper

Erik O. Gabrielsson, Klas Tybrandt, Magnus Berggren
Micro-fabricated ion diodes based on bipolar membranes showing low hysteresis are used as components in a ionic circuit for pH control.
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Polyethyleneimine coating renders polycarbonate resistant to organic solvents

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21297H, Paper

Pawel Jankowski, Dominika Ogonczyk, Wojciech Lisowski, Piotr Garstecki
Polyethyleneimine coating of polycarbonate microfluidic chips allows for handling of organic reactions in toluene, benzene, acetonitrile, tetrahydrofuran, dioxane, acetone, THF, ethyl acetate and ethylene dichloride.
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Contributors to the USA issue

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC90053J, Profile

Lab on a Chip profiles the contributors to the USA issue.
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Lab on a chip: United States of America

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC90052A, Editorial

Donald E. Ingber, George M. Whitesides
The Wyss Institute Symposium on "Microfluidics and Medicine: Accelerating the Flow from Lab to the Clinic", which inspired this issue, focused on work in the microfluidics field that promises to have a transformative impact on medicine and clinical care.
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A ternary model for double-emulsion formation in a capillary microfluidic device

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21235H, Paper

Jang Min Park, Patrick D. Anderson
A ternary diffuse-interface model is presented to predict double-emulsion formation in a capillary microfluidic device.
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Induced hydrophobic recovery of oxygen plasma-treated surfaces

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21052E, Technical Innovation

David J. Guckenberger, Erwin Berthier, Edmond W. K. Young, David J. Beebe
We describe a practical and cheap technique to induce hydrophobic recovery of plasma-treated surfaces that can be easily adopted by any lab with access to common lab supplies such as tapes and wipers.
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Isothermal nucleic acid amplification technologies for point-of-care diagnostics: a critical review

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40100B, Critical Review

Pascal Craw, Wamadeva Balachandran
An up-to-date review of existing isothermal nucleic acid amplification technologies and their implementation in point-of-care diagnostic instrumentation.
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High Throughput Method for Prototyping Three-Dimensional, Paper-Based Microfluidic Devices

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40331E, Technical Innovation

Gregory G Lewis, Matthew J DiTucci, Matthew S Baker, Scott Phillips
This paper describes an efficient and high throughput method for fabricating three-dimensional (3D) paper-based microfluidic devices. The method avoids tedious alignment and assembly steps and eliminates a major bottleneck that...
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Thermoplastic fusion bonding using a pressure-assisted boiling point control system

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40252A, Technical Innovation

Taehyun Park, In-Hyouk Song, Daniel S. Park, Byoung Hee You, Michael C. Murphy
One of critical steps in manufacturing polymer microfluidic devices is the sealing process used to obtain closed structures containing microchannels. A novel thermoplastic fusion bonding method using a pressure-assisted boiling...
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Biocompatible "Click" Wafer Bonding for Microfluidic Devices

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21098C, Technical Innovation

Farizah Saharil, Carl Fredrik Carlborg, Tommy Haraldsson, Wouter Wouter van der Wijngaart
We introduce a novel dry wafer bonding concept designed for permanent attachment of micromolded polymer structures to chemically functionalized silicon substrates. The method, designed for simultaneous fabrication of many lab-on-chip...
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Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40114B, Paper

melania paturzo, andrea finizio, PASQUALE MEMMOLO, Roberto Puglisi, Donatella Balduzzi, Andrea Galli, Pietro Ferraro
We show that sharp imaging and quantitative phase-contrast microcopy is possible in microfluidics in flowing turbid media by digital holography. In fact, in flowing liquids with suspended colloidal particles, clear...
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Lab-in-a-Tube: on-chip integration of glass optofluidic ring resonators for label-free sensing applications

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40275K, Paper

Stefan M Harazim, Vladimir A. Bolanos Quinones, Suwit Kiravittaya, Samuel Sanchez, Oliver Schmidt
The fabrication of tubular rolled-up optofluidic ring resonators (RU-OFRRs) based on glass (SiO2) material with high quality factors is reported. A novel methodology combining lab-on-a-chip fabrication methods and rolled-up nanotech...
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Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40213K, Paper

Javier Ramon, Samad Ahadian, Raquel Obregon, Gulden Camci-Unal, Serge Ostrovidov, Vahid Hosseini, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue
Establishing the 3D microscale organization of cells has numerous practical applications, such as in determining cell fate (e.g., proliferation, migration, differentiation, and apoptosis) and in making functional tissue constructs. One...
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Inverted open microwells for cell trapping, cell aggregate formation and parallel recovery of live cells

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40124J, Paper

Massimo Bocchi, Laura Rambelli, Andrea Faenza, Luca Giulianelli, Nicola Pecorari, Enri Duqi, Jean-Charles Gallois, Roberto Guerrieri
The inverted open microwell is a novel microstructure supporting isolation of single cells, analysis of cell-cell and cell-molecule interactions and functional cell sorting. This work introduces the inverted open microwell...
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Nanowire-integrated microfluidic devices for facile and reagent-free mechanical cell lysis

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40154A, Paper

Jung Kim, Jung Woo Hong, Dong-Pyo Kim, Jennifer H Shin, Inkyu Park
Cell lysis is an essential task for the diagnosis of intracellular components. In this work, we introduce novel microfluidic devices integrated with patterned one-dimensional nanostructure arrays for the facile and...
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Continuous operation of a hybrid solid-liquid state reconfigurable photonic system without resupply of liquids

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40191F, Paper

Erica Eunjung Jung, David Erickson
This paper describes an optofluidically reconfigurable photonic system without the need for continuous resupply of liquids during the operation.
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A microfluidic device for whole-animal drug screening using electrophysiological measures in the nematode C. elegans

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC00001F, Paper

Shawn R. Lockery, S. Elizabeth Hulme, William M. Roberts, Kristin J. Robinson, Anna Laromaine, Theodore H. Lindsay, George M. Whitesides, Janis C. Weeks
This paper describes the fabrication and use of a microfluidic device for performing whole-animal chemical screens using non-invasive electrophysiological readouts of neuromuscular function in the nematode worm, C. elegans.
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Microfluidic synthesis of multifunctional Janus particles for biomedical applications

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC90046G, Focus

Shikuan Yang, Feng Guo, Brian Kiraly, Xiaole Mao, Mengqian Lu, Kam W. Leong, Tony Jun Huang
Tony Jun Huang and co-workers discuss microfluidic synthesis of multifunctional Janus particles for biomedical applications - Part of a series of Focus articles elucidating bio-related issues that impact on lab on a chip and microfluidic research.
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High-throughput biophysical measurement of human red blood cells

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21210B, Paper

Yi Zheng, Ehsan Shojaei-Baghini, Azar Azad, Chen Wang, Yu Sun
This paper describes a microfluidic system for biophysically characterizing and classifying human RBCs at a speed of [similar]120 cells s^-1.
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A facile route for the fabrication of large-scale gate-all-around nanofluidic field-effect transistors with low leakage current

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40112F, Paper

Sangwoo Shin, Beom Seok Kim, Jiwoon Song, Hwanseong Lee, Hyung Hee Cho
We report a rapid, cost-effective route for the fabrication of large-scale nanofluidic field-effect transistors using a simple, lithography-free two-step fabrication process that consists of sputtering and barrier-type anodization.
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Sucrose-based fabrication of 3D-networked, cylindrical microfluidic channel for rapid-prototyping of lab-on-a-chip and vaso-mimetic device

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40267J, Technical Innovation

Jiwon Lee, Jungwook Paek, Jaeyoun Kim
We present a new fabrication scheme for 3D-networked, cylindrical microfluidic (MF) channels based on shaping, bonding, and assembly of sucrose fibers. It is a simple, cleanroom-free, and environment-friendly method ideal...
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Oxygenation by a superhydrophobic slip G/L contactor

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21296J, Paper

Elif Karatay, Rob Lammertink
The compelling need for efficient supply of gases into liquids or degassing of fluids within confined microchannels triggered our study on membrane assisted microchemical systems. Microporous, hydrophobic, flat/micro-structured polyvinylidene fluoride...
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Heterotypic Cell Pair Co-culturing on Patterned Microarrays

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40349H, Paper

Edward James Felton, Craig R Copeland, Christopher S. Chen, Daniel Henry Reich
We present a pair-wise co-culturing technique that creates large numbers of heterotypic cell pairs in patterned arrays. Lithographic patterning produces arrays with thousands of traps, each designed to accommodate only...
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A Compact Optofluidic Cytometer with Integrated Liquid-core/PDMS-cladding Waveguides

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40329C, Paper

Peng Fei, Zitian Chen, Yongfan Men, Ang Li, Yiran Shen, Yanyi Huang
We developed a simple method to construct liquid-core/PDMS-cladding optical waveguides through pressurized filling of dead-ended micro-channels with optical fluids. The waveguides are in the same layer as microfluidic channels which...
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Microfabricated Ratchet Structure Integrated Concentrator Arrays for Synthetic Bacterial Cell-to-Cell Communication Assays

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40294G, Paper

Taesung Kim
We describe a microfluidic concentrator array device that is integrated with microfabricated ratchet structures to concentrate motile bacterial cells in desired destinations with required cell densities. Since the device consists...
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SSA-MOA: A Novel CTC Isolation Platform Using Selective Size Amplification (SSA) and a Multi-Obstacle Architecture (MOA) Filter

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40065K, Paper

Minseok S Kim, Tae Seok Sim, Yeon Jeong Kim, Sun Soo Kim, Hyoyoung Jeong, Jong-Myeon Park, Hui-Sung Moon, Seung-Il Kim, Ogan Gurel, Soo Suk Lee, Jeong Gun Lee, Jae Chan Park
Circulating tumor cells (CTCs) have gained increasing attention as physicians and scientists learn more about the role of these extraordinarily rare cells in metastatic cancer. In developing CTC technology, the...
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UV epoxy bonding for enhanced SAW transmission and microscale acoustofluidic integration

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40085E, Method

Sean Langelier, Leslie Yeo, James R. Friend
Surface acoustic waves (SAWs) are appealing as a means to manipulate fluids within lab-on-a-chip systems. However, current acoustofluidic devices almost universally rely on elastomeric materials, especially PDMS, that are inherently...
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Digital Microfluidics: A Versatile Tool For Applications in Chemistry, Biology and Medicine

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40318H, Critical Review

Mais J. Jebrail, Michael S. Bartsch, Kamlesh D Patel
Digital microfluidics (DMF) has recently emerged as a popular technology for a wide range of applications. In DMF, nanoliter to microliter droplets containing samples and reagents can be manipulated to...
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On-chip electroporation, membrane repair dynamics and transient in-cell recordings by arrays of gold mushroom-shaped microelectrodes

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40091J, Paper

Aviad Hai, Micha E Spira
The study demonstrates the use of on-chip gold mushroom-shaped microelectrodes (gM[small micro]Es) to generate localized electropores in the plasma membrane of adhering cultured neurons and to electrophysiologically monitor the ensuing membrane...
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Fluorinated liquid-enabled protein handling and surfactant-aided crystallization for fully in situ digital microfluidic MALDI-MS analysis

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21135A, Paper

Andrew P. Aijian, Debalina Chatterjee, Robin L. Garrell
Complete in situ peptide mass fingerprinting is performed on a digital microfluidic device using fluorinated liquid encapsulation to facilitate movement of the protein droplet and a fluorinated surfactant (PFOA) to enhance matrix co-crystallization and MALDI-MS spectral quality.
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Concurrent recordings of bladder afferents from multiple nerves using a microfabricated PDMS microchannel electrode array

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21277C, Paper

Evangelos Delivopoulos, Daniel J. Chew, Ivan R. Minev, James W. Fawcett, Stephanie P. Lacour
We present a compliant neural interface to record bladder afferent activity from L6 and S1 dorsal rootlets of an anaesthitized rat.
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Control of the length of microfibers

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40280G, Communication

Janine K. Nunes, Krzysztof Sadlej, Jee Ian Tam, Howard A. Stone
We developed a simple microfluidic method for synthesizing polymeric microfibers, where the fiber length can be systematically varied as a function of valve frequency.
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In vitro and in vivo testing of glucose-responsive insulin-delivery microdevices in diabetic rats

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40139H, Paper

Michael K. L. Chu, Jian Chen, Claudia R. Gordijo, Simon Chiang, Alexander Ivovic, Khajag Koulajian, Adria Giacca, Xiao Yu Wu, Yu Sun
We have developed an implantable, glucose-responsive microdevice that shows rapid in vitro and in vivo efficacy in a diabetic rat model.
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Diagnostic microchip to assay 3D colony-growth potential of captured circulating tumor cells

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40130D, Technical Innovation

Colette A. Bichsel, Samy Gobaa, Stefan Kobel, Chiara Secondini, George N. Thalmann, Marco G. Cecchini, Matthias P. Lutolf
Microfluidic immunocapture of circulating tumor cells was merged with three-dimensional (3D) cell culture on the same chip to assess clonal 3D spheroid growth potential.
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High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21290K, Paper

Angela R. Wu, Tiara L.A. Kawahara, Nicole A. Rapicavoli, Jan van Riggelen, Emelyn H. Shroff, Liwen Xu, Dean W. Felsher, Howard Y. Chang, Stephen R. Quake
An automated microfluidic-based, high-throughput platform for chromatin immunoprecipitation screening that is sensitive enough to detect cytokine-induced cellular epigenetic changes over a fine temporal resolution.
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Carbon nanotube based stationary phases for microchip chromatography

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40102A, Critical Review

Klaus B. Mogensen, Jorg P. Kutter
The unique properties of carbon nanotubes and related carbon based nanomaterials for microchip chromatography are critically reviewed.
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Enriching carbonylated proteins inside a microchip through the use of oxalyldihydrazide as a crosslinker

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40103G, Paper

Bryant C. Hollins, Steven A. Soper, June Feng
This report demonstrates the use of oxalyldihydrazide as a novel crosslinker for enrichment of carbonylated proteins inside a disposable, polymeric microfluidic device.
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Single-Step Multiplex Detection of Toxic Metal Ions by Au Nanowires-on-Chip Sensor Using Reporter Elimination

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40185A, Paper

Taejoon Kang, Seung Min Yoo, Mijeong Kang, Hyoban Lee, Hongki Kim, Sang Yup Lee, Bongsoo Kim
We have developed Au nanowires (NWs)-on-chip surface-enhanced Raman scattering (SERS) multiplex sensor that can sensitively detect multiple toxic metal ions. Most importantly, reporter elimination method simplified the detection procedure to...
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Acoustofluidics 12: Biocompatibility and cell viability in microfluidic acoustic resonators

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40201G, Focus

Martin Wiklund
In this focus article we discuss the factors defining the biocompatibility of a micro-device for ultrasonic cell manipulation, and different methods to measure cell viability.
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Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40141J, Communication

Fernando Cruz Moraes, Renato Sousa Lima, Thiago Pinotti Segato, Ivana Cesarino, Jhanisus Leonel Melendez Cetino, Sergio Antonio Spinola Machado, Frank Gomez, Emanuel Carrilho
Microfluidic device with vertically aligned SWCNTs that requires a simple microfabrication/functionalization protocol and allows direct and ultrasensitive determinations of serotonin.
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Microengineered physiological biomimicry: Organs-on-Chips

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40089H, Frontier

Dongeun Huh, Yu-suke Torisawa, Geraldine A. Hamilton, Hyun Jung Kim, Donald E. Ingber
Microscale engineering technologies provide unprecedented opportunities to create cell culture microenvironments that go beyond current three-dimensional in vitro models by recapitulating the critical tissue-tissue interfaces, spatiotemporal chemical gradients, and dynamic mechanical microenvironments of living organs.
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Microfluidic Apps for off-the-shelf instruments

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC00043A, Critical Review

Daniel Mark, Felix von Stetten, Roland Zengerle
This article promotes the idea of "Microfluidic Apps"; microfluidic chips that are designed to extend the functionality of existing instruments.
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Thermal analysis of nanofluids in microfluidics using an infrared camera

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40222J, Paper

Pyshar Yi, Aminuddin A. Kayani, Adam F. Chrimes, Kamran Ghorbani, Saeid Nahavandi, Kourosh Kalantar-zadeh, Khashayar Khoshmanesh
We present the thermal analysis of liquid containing Al₂O₃ nanoparticles in a microfluidic platform using an infrared camera.
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Optimized preparation of pDNA/poly(ethylene imine) polyplexes using a microfluidic system

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40176B, Paper

Heiko Debus, Moritz Beck-Broichsitter, Thomas Kissel
A microfluidic method for polyplex formation with poly(ethylene imine) and nucleic acids was compared with the standard pipetting method.
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Proteolysis in microfluidic droplets: an approach to interface protein separation and peptide mass spectrometry

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40206H, Communication

Ji Ji, Lei Nie, Liang Qiao, Yixin Li, Liping Guo, Baohong Liu, Pengyuan Yang, Hubert H Girault
A versatile microreactor protocol based on microfluidic droplets has been developed for on-line protein digestion. Proteins separated by liquid chromatography are fractionated in water-in-oil droplets and digested in sequence. The...
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Microfluidic Very Large Scale Integration (mVLSI) with Integrated Micromechanical Valves

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40258K, Technical Innovation

Ismail Emre Araci, Stephen Quake
Microfluidic chips with a high density of control elements are required to improve device performance parameters such as throughput, sensitivity and dynamic range. In order to realize robust and accessible...
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Research highlights

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC90045A, Highlight

Seila Selimovic, Cole A. DeForest, Mehmet R. Dokmeci, Ali Khademhosseini
Hydrodynamic tweezers - Combinatorial concentration gradients for drug screening - Culturing endothelial cells on micropillars.
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On-chip electrochemical detection of CdS quantum dots using normal and multiple recycling flow through modes

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC00007E, Paper

Mariana Medina-Sanchez, Sandrine Miserere, Sergio Marin, Gemma Aragay, Arben Merkoci
A flexible hybrid polydimethylsiloxane-polycarbonate microfluidic chip with integrated screen printed electrodes was fabricated and applied for electrochemical quantum dots detection.
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Contactless conductivity biosensor in microchip containing folic acid as bioreceptor

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40157F, Communication

Renato S. Lima, Maria H. O. Piazzetta, Angelo L. Gobbi, Ubirajara P. Rodrigues-Filho, Pedro A. P. Nascente, Wendell K. T. Coltro, Emanuel Carrilho
Microfluidic system (a-c) for real time monitoring of biomolecular interactions (d) using capacitively coupled contactless conductivity transduction and FA as a bioreceptor.
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High-throughput immunoassay through in-channel microfluidic patterning

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40145B, Communication

Chunhong Zheng, Jingwen Wang, Yuhong Pang, Jianbin Wang, Wenbin Li, Zigang Ge, Yanyi Huang
Pneumatic button valves enable surface patterning inside microfluidic channels and facilitate highly sensitive and robust immunoassays.
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Electrical fingerprinting, 3D profiling and detection of tumor cells with solid-state micropores

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21012F, Paper

Waseem Asghar, Yuan Wan, Azhar Ilyas, Robert Bachoo, Young-tae Kim, Samir M. Iqbal
We present a solid-state micropore based device that can differentiate cancer cells from whole blood with more than 85% detection efficiency.
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Ion channel drug potency assay with an artificial bilayer chip

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40087A, Paper

Ahmad M. El-Arabi, Carl S. Salazar, Jacob J. Schmidt
We present an automation and array compatible artificial bilayer chip and its use for measurements of drug potency on the TRPM8 ion channel.
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Analytical miniaturization and nanotechnologies

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC90040H, Editorial

Arben Merkoci, Jorg P. Kutter
This Lab on a Chip themed issue is in collaboration with the III International Workshop on Analytical Miniaturization and NANOtechnologies, Barcelona, 2012.
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Printed two-dimensional photonic crystals for single-step label-free biosensing of insulin under wet conditions

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40066A, Paper

Tatsuro Endo, Masaya Sato, Hiroshi Kajita, Norimichi Okuda, Satoru Tanaka, Hideaki Hisamoto
Two-dimensional photonic crystals (2D-PCs) fabricated on a cyclo-olefin polymer (COP) film using a printable photonics technology based on nano-imprint lithography (NIL) were used for label-free biosensing of insulin under wet conditions.
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Microreactor with integrated temperature control for the synthesis of CdSe nanocrystals

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC00011C, Paper

Sara Gomez-de Pedro, Cynthia S. Martinez-Cisneros, Mar Puyol, Julian Alonso-Chamarro
Here we present a ceramic based microfluidic system to perform controlled high temperature synthetic reactions of nanocrystals.
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Nanophotonic lab-on-a-chip platforms including novel bimodal interferometers, microfluidics and grating couplers

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40054E, Paper

Daphne Duval, Ana Belen Gonzalez-Guerrero, Stefania Dante, Johann Osmond, Rosa Monge, Luis J. Fernandez, Kirill E. Zinoviev, Carlos Dominguez, Laura M. Lechuga
We show the implementation of a label-free biosensing LOC platform based on photonic interferometric sensors integrated with a novel all-optical wavelength modulation system, sub-micronic grating couplers and a SU-8 microfluidics network.
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Microfluidic electronics

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21176A, Critical Review

Zhigang WU, Shi Cheng
In contrast to intensive and extensive studies in biology, applications in electronics for microfluidics are less discovered. Exploiting native advantages of microfluidics, recent advances in microfluidic electronics show high potential...
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Wafer-scale Mitochondrial Membrane Potential Assays

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40086C, Paper

Peter John Burke, Tae_Sun Lim, Antonio Davila Jr, Katayoun Zand, Douglas C. Wallace
It has been reported that mitochondrial metabolic and biophysical parameters are associated with degenerative diseases and the aging process. To evaluate these biochemical parameters, current technology requires several hundred milligrams...
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A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC00030J, Paper

Tingjiao Liu, Jianhua Qin, Qian Zhang
Circulating tumor aggregates exhibit a high metastatic potential and could potentially serve as an important target for cancer therapies. In this study, we bioengineered a microfluidic model that reconstitutes and...
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High-yield cell ordering and deterministic cell-in-droplet encapsulation using Dean flow in a curved microchannel

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC00013J, Paper

evelien kemna, rogier schoeman, floor Wolbers, Istvan Vermes, David Alain Weitz, Albert van den Berg
In this article high-yield (77%) and high-speed (2700 cells s-1) single cell droplet encapsulation is described using Dean-coupled inertial ordering of cells in a simple curved continuous microchannel. We use...
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Genotyping from saliva with a one-step microdevice

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC00010E, Paper

Ilija Pjescic, Niel Crews
Genetic results can be obtained directly from saliva within twenty minutes using microfluidics for simultaneous PCR and DNA melting analysis.
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Quantum dot enabled thermal imaging of optofluidic devices

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40181A, Paper

Debaditya Choudhury, Daniel Jaque, Airan Rodenas, William T. Ramsay, Lynn Paterson, Ajoy K. Kar
We present quantum dot enabled nanothermometry in an ultrafast laser inscribed optofluidic device.
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Brain slice on a chip: opportunities and challenges of applying microfluidic technology to intact tissues

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21142D, Tutorial Review

Yu Huang, Justin C. Williams, Stephen M. Johnson
Isolated brain tissue, especially brain slices, are valuable experimental tools for studying neuronal function at the network, cellular, synaptic, and single channel levels.
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Passive control of cell locomotion using micropatterns: the effect of micropattern geometry on the migratory behavior of adherent cells

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40084G, Paper

Sang-Hee Yoon, Young Kyun Kim, Eui Don Han, Young-Ho Seo, Byeong Hee Kim, Mohammad R. K. Mofrad
The changes in the migratory behavior of adherent cells exposed to physical spatial cues are explored using a microfabricated biological platform, nicknamed the "Rome platform".
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A microfluidic-based frequency-multiplexing impedance sensor (FMIS)

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40236J, Paper

Robert Meissner, Pierre Joris, Bilge Eker, Arnaud Bertsch, Philippe Renaud
We are presenting a novel technology for simultaneous and simple impedimetric screening of multiple microfluidic channels with only one electrode pair. We have exploited the frequency dimension to distinguish between...
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Microfluidic Droplet Sorting with a High Frequency Ultrasound Beam

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21123H, Paper

Changyang Lee, Jungwoo Lee, Hyung Ham Kim, Shia-Yen Teh, Abraham Lee, In-Young Chung, Jaeyeong Park, Koping Kirk Shung
This paper presents experimental results demonstrating the feasibility of high frequency ultrasonic sensing and sorting for screening single droplets under continuous flow in a microfluidic channel. In these experiments, hydrodynamically...
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On-Chip Ultra-Thin Layer Chromatography and Surface Enhanced Raman Spectroscopy

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40221A, Paper

Jing Chen, Justin Abell, Yao-wen Huang, Y.-P. Zhao
We demonstrate that silver nanorod (AgNR) array substrates can be used for on-chip separation and detection of chemical mixtures by combining ultra-thin layer chromatography (UTLC) and surface enhanced Raman spectroscopy...
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Cell-free protein synthesis from a single copy of DNA in a glass microchamber

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40098G, Paper

Taiji Okano, Tomoaki Matsuura, Yasuaki Kazuta, Hiroaki Suzuki, Tetsuya Yomo
To achieve a cell-mimetic reaction environment, we fabricated and tested microchambers made of quartz (designated as glass microchamber) for conducting protein synthesis using an in vitro transcription and translation system....
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Pinned Films and Capillary Hysteresis in Microfluidic Channels

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40247E, Paper

Yihong Liu, David Nolte, Laura J. Pyrak-Nolte
Pinned water films in a microfluidic channel act as elastic membranes under tension that increase capillary pressures while preserving the mechanical work dissipated around pressure-saturation hysteresis cycles. High-resolution two-photon laser...
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A Microfluidic "Baby Machine" for Cell Synchronization

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40277G, Paper

Josephine W. Shaw, Kristofor Payer, Sungmin Son, William Grover, Scott Manalis
Common techniques used to synchronize eukaryotic cells in the cell cycle often impose metabolic stress on the cells or physically select for size rather than age. To address these deficiencies,...
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High NIR-purity index single-walled carbon nanotubes for electrochemical sensing in microfluidic chips

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40099E, Paper

Diana Vilela, Alejandro Anson-Casaos, Maria Teresa Martinez, Maria Cristina Gonzalez, Alberto Escarpa
High NIR-purity index oxidized SWCNTs for electrochemical sensing in microfluidic chips.
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Capillary soft valves for microfluidics

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC00015F, Paper

Martina Hitzbleck, Laetitia Avrain, Valerie Smekens, Robert D. Lovchik, Pascal Mertens, Emmanuel Delamarche
We present capillary soft valves for stopping liquids in capillary-driven microfluidics. These valves are simple to implement and can be actuated by pressing them with, for example, the tip of a pen.
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