Themed collection Recent Review Articles
Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use
Matthew and Rumack (200 mg or UK ‘Prescott’ line) and the 150 mg Treatment line, both on log scales.
Toxicol. Res., 2019,8, 489-498
https://doi.org/10.1039/C9TX00002J
A review of arsenic exposure and lung cancer
As a well-established human carcinogen, arsenic has increased the risk of lung cancer over the past decades.
Toxicol. Res., 2019,8, 319-327
https://doi.org/10.1039/C8TX00298C
Mechanisms of DNA-reactive and epigenetic chemical carcinogens: applications to carcinogenicity testing and risk assessment
Chemicals with carcinogenic activity in either animals or humans produce increases in neoplasia through diverse mechanisms.
Toxicol. Res., 2019,8, 123-145
https://doi.org/10.1039/C8TX00250A
Rethinking and new perspectives on cardiotoxicity of traditional Chinese medicine
Traditional Chinese Medicine (TCM) has been commonly used in clinical practice for thousands of years and has made enormous contributions to public health in China.
Toxicol. Res., 2019,8, 7-14
https://doi.org/10.1039/C8TX00271A
Thalidomide-type teratogenicity: structure–activity relationships for congeners
Unravelling the molecular basis of thalidomide embryotoxicity, which is remarkably species-specific, is challenging in view of its low toxicity in the mature animal.
Toxicol. Res., 2018,7, 1036-1047
https://doi.org/10.1039/C8TX00187A
Phototoxicity of traditional chinese medicine (TCM)
Phototoxicity can cause toxic responses such as edemas and lesions, and is one of the severe adverse effects that largely limit the use of these phototoxic drugs.
Toxicol. Res., 2018,7, 1012-1019
https://doi.org/10.1039/C8TX00141C
Maternal SSRIs experience and risk of ASD in offspring: a review
Antidepressants are extensively used during pregnancy and associated with severe outcomes, including innate malformations, prematurity, and low birth weight, etc.
Toxicol. Res., 2018,7, 1020-1028
https://doi.org/10.1039/C8TX00102B
Cellular and molecular mechanisms of sulfur mustard toxicity on spermatozoa and male fertility
Sulfur mustard (SM) is a toxic compound that can target human spermatozoa.
Toxicol. Res., 2018,7, 1029-1035
https://doi.org/10.1039/C8TX00062J
Delayed death following paraquat poisoning: three case reports and a literature review
Paraquat (PQ) poisoning is the main medical problem in developing countries and it is spread out worldwide. A similar structure of PQ to MPP+ (1-methyl-4-phenylpyridinium) caused PQ-induced neurotoxicity and injury to renal proximal tubules.
Toxicol. Res., 2018,7, 745-753
https://doi.org/10.1039/C8TX00120K
Big-data and machine learning to revamp computational toxicology and its use in risk assessment
The creation of large toxicological databases and advances in machine-learning techniques have empowered computational approaches in toxicology.
Toxicol. Res., 2018,7, 732-744
https://doi.org/10.1039/C8TX00051D
The association between chemical-induced porphyria and hepatic cancer
The haem biosynthetic pathway is of fundamental importance for cellular metabolism both for the erythroid and nonerythroid tissues.
Toxicol. Res., 2018,7, 647-663
https://doi.org/10.1039/C8TX00019K
Role of xenobiotics in the induction and progression of fatty liver disease
Non-alcoholic fatty liver disease is a major cause of chronic liver pathology in humans.
Toxicol. Res., 2018,7, 664-680
https://doi.org/10.1039/C7TX00326A
The safety evaluation of food flavouring substances: the role of metabolic studies
The safety assessment of a flavour substance examines several factors, including metabolic and physiological disposition data.
Toxicol. Res., 2018,7, 618-646
https://doi.org/10.1039/C7TX00254H
Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators
A large number of nongenotoxic chemicals have been shown to increase the incidence of liver tumours in rats and/or mice by a mode of action (MOA) involving activation of the constitutive androstane receptor (CAR).
Toxicol. Res., 2018,7, 697-717
https://doi.org/10.1039/C8TX00008E
Chromatin dynamics underlying latent responses to xenobiotics
Xenobiotic-induced perturbations of somatic tissue or germline epigenomes may underlie delayed-onset and long-lasting adverse effects.
Toxicol. Res., 2018,7, 606-617
https://doi.org/10.1039/C7TX00317J
Goodbye to the bioassay
It is time to say goodbye to the standard two-year rodent bioassay.
Toxicol. Res., 2018,7, 558-564
https://doi.org/10.1039/C8TX00004B
Collaboration and competition: ethics in toxicology
Toxicology has frequently been a focus of scientific and societal concern. It's time to examine practices such as peer review, resourcing, transparency and data sharing to ensure the field stays current, relevant and ethical.
Toxicol. Res., 2018,7, 576-585
https://doi.org/10.1039/C7TX00306D
Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway
Sensitisation of the respiratory tract to chemicals resulting in respiratory allergy and allergic asthma is an important occupational health problem, and presents toxicologists with no shortage of challenges.
Toxicol. Res., 2018,7, 586-605
https://doi.org/10.1039/C7TX00272F
Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action
The CAR-mediated MOA for liver tumorigenesis is of no carcinogenic risk for humans.
Toxicol. Res., 2018,7, 681-696
https://doi.org/10.1039/C7TX00288B
The state of bisphenol research in the lesser developed countries of the EU: a mini-review
Bisphenol compounds are a class of chemical epoxy resins that are found throughout the world in food packaging, thermal paper products, dental materials, and more.
Toxicol. Res., 2018,7, 371-380
https://doi.org/10.1039/C8TX00064F
Evaluation of the relevance of DILI predictive hypotheses in early drug development: review of in vitro methodologies vs. BDDCS classification
Drug-induced liver injury (DILI) is a major safety concern; it occurs frequently; it is idiosyncratic; it cannot be adequately predicted; and a multitude of underlying mechanisms has been postulated.
Toxicol. Res., 2018,7, 358-370
https://doi.org/10.1039/C8TX00016F
Anticancer, antimicrobial, and analgesic activities of spider venoms
Spider venoms are complex mixtures composed of a variety of compounds, including salts, small organic molecules, peptides, and proteins.
Toxicol. Res., 2018,7, 381-395
https://doi.org/10.1039/C8TX00022K
Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective
After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, N-acetyl-p-aminophenol, APAP) remains the subject of considerable research into both its mode of action and toxicity.
Toxicol. Res., 2018,7, 347-357
https://doi.org/10.1039/C7TX00340D
The impact of nanomaterial characteristics on inhalation toxicity
Due an increasing use of nanotechnology and a ubiquitous human exposition to airborne nanomaterials, this review underlines the importance of the detailed investigation of NM characteristics and the relations to their toxicologic effects.
Toxicol. Res., 2018,7, 321-346
https://doi.org/10.1039/C7TX00242D
About this collection
Toxicology Research publishes authoritative and insightful review articles covering all aspects of the journal scope. In this collection, we have brought together recent reviews published in the journal– we hope you enjoy reading them.