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Themed collection Top 50 Articles of 2016: Analytical, Biological and Medicinal Chemistry

15 items
Open Access Perspective

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes.

Graphical abstract: Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
From the themed collection: Top 50 Articles of 2016: Organic Chemistry
Open Access Minireview

Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry

The use of site-selective chemical drug-conjugation strategies enables the construction of antibody–drug conjugates (ADCs) with superior therapeutic efficacy.”

Graphical abstract: Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry
From the themed collection: Global challenges: Health & Food
Open Access Minireview

Peptide-based synthetic vaccines

This review summarise the current stand and future perspective on synthetic peptide-based vaccines.

Graphical abstract: Peptide-based synthetic vaccines
From the themed collection: Top 50 Articles of 2016: Organic Chemistry
Open Access Edge Article

A unique approach toward near-infrared fluorescent probes for bioimaging with remarkably enhanced contrast

A universal sensing platform with significantly enhanced image contrast and apparent brightness in biological imaging applications.

Graphical abstract: A unique approach toward near-infrared fluorescent probes for bioimaging with remarkably enhanced contrast
Open Access Edge Article

Structurally plastic peptide capsules for synthetic antimicrobial viruses

A conceptual design for artificial antimicrobial viruses is described.

Graphical abstract: Structurally plastic peptide capsules for synthetic antimicrobial viruses
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Single near-infrared fluorescent probe with high- and low-sensitivity sites for sensing different concentration ranges of biological thiols with distinct modes of fluorescence signals

We describe a unique approach for the development of an interesting type of the fluorescent probes, which can show different modes of fluorescence signals to distinct concentration ranges of a target of interest.

Graphical abstract: Single near-infrared fluorescent probe with high- and low-sensitivity sites for sensing different concentration ranges of biological thiols with distinct modes of fluorescence signals
Open Access Edge Article

A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

A probe for the in situ monitoring of singlet oxygen generation during targeted theranostic photodynamic therapy is developed based on a photosensitizer with aggregation-induced emission (AIE) characteristics and conjugated to a fluorogenic rhodol dye via a singlet oxygen cleavable linker.

Graphical abstract: A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

An ultrasensitive near-infrared ratiometric fluorescent probe for imaging mitochondrial polarity in live cells and in vivo

We describe a new mitochondria-targeting fluorescent probe MCY-BF2 that is singularly sensitive and specifically responsive to mitochondrial polarity.

Graphical abstract: An ultrasensitive near-infrared ratiometric fluorescent probe for imaging mitochondrial polarity in live cells and in vivo
Open Access Edge Article

A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis

A selective quenched activity-based probe detects caspase-3 activity in the endoplasmic reticulum of cancerous cells during apoptosis.

Graphical abstract: A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

A highly selective near-infrared fluorescent probe for imaging H2Se in living cells and in vivo

The first near-infrared fluorescent probe to detect H2Se with high sensitivity was explored in living cells and in mice.

Graphical abstract: A highly selective near-infrared fluorescent probe for imaging H2Se in living cells and in vivo
Open Access Edge Article

LNA-enhanced DNA FIT-probes for multicolour RNA imaging

A surrogate nucleobase based on 4,4'-cyanine provided up to 195-fold enhancement of red fluorescence upon complementary RNA binding. A mixture of FIT probes allowed the localization of oskar mRNA and other polyadenylated mRNA molecules in developing oocytes from Drosphila melanogaster by wash-free FISH and STED.

Graphical abstract: LNA-enhanced DNA FIT-probes for multicolour RNA imaging
Open Access Edge Article

Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid

Oxidation of a protein cysteine thiol to sulfenic acid, termed S-sulfenylation, is a reversible post-translational modification that plays a crucial role in regulating protein function and is correlated with disease states.

Graphical abstract: Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

An optoelectronic nose for identification of explosives

A portable optoelectronic nose for the identification of explosives uses a highly cross-reactive colorimetric sensor array and a handheld scanner.

Graphical abstract: An optoelectronic nose for identification of explosives
Open Access Edge Article

Accurate calculation of the absolute free energy of binding for drug molecules

Free energy calculations based on molecular dynamics and thermodynamic cycles accurately reproduce experimental affinities of diverse bromodomain inhibitors.

Graphical abstract: Accurate calculation of the absolute free energy of binding for drug molecules
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

A minimalist fluorescent probe for differentiating Cys, Hcy and GSH in live cells

A simple and versatile probe was discovered for discriminating between different thiol species with the use of CTAB (cetyl trimethylammonium bromide).

Graphical abstract: A minimalist fluorescent probe for differentiating Cys, Hcy and GSH in live cells
15 items

About this collection

We are delighted to present a collection showcasing the 50 most downloaded Chemical Science articles of 2016. This is only available for a limited time and provides an easy way to quickly access the most important papers published in Chemical Science in the past year. These articles highlight exciting and impactful research across a broad range of subject areas, analytical chemistry, chemical biology, catalysis, energy, inorganic chemistry, materials science, nanoscience, organic chemistry and physical chemistry. We hope you enjoy reading this collection!

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