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Themed collection Global challenges: Health & Food

77 items - Showing page 1 of 2
Open Access Perspective

Sulfonyl fluorides as privileged warheads in chemical biology

The use of sulfonyl fluoride probes in chemical biology is reviewed.

Graphical abstract: Sulfonyl fluorides as privileged warheads in chemical biology
From the themed collection: Global challenges: Health & Food
Open Access Perspective

Combination of Ru(II) complexes and light: new frontiers in cancer therapy

In this perspective article, we present the recent achievements in the application of ruthenium complexes as photosensitizers and as photoactivatable prodrugs.

Graphical abstract: Combination of Ru(ii) complexes and light: new frontiers in cancer therapy
From the themed collection: Global challenges: Health & Food
Open Access Perspective

Macrocycles: lessons from the distant past, recent developments, and future directions

A noticeable increase in molecular complexity of drug targets has created an unmet need in the therapeutic agents that are larger than traditional small molecules.

Graphical abstract: Macrocycles: lessons from the distant past, recent developments, and future directions
From the themed collection: Global challenges: Health & Food
Open Access Minireview

Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry

The use of site-selective chemical drug-conjugation strategies enables the construction of antibody–drug conjugates (ADCs) with superior therapeutic efficacy.”

Graphical abstract: Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry
From the themed collection: Global challenges: Health & Food
Open Access Minireview

Asymmetric 18F-fluorination for applications in positron emission tomography

To date, both transition metal complexes and organomediators have been employed for enantiocontrolled 18F-incorporation as an alternative to conventional resolution of SN2-based radiochemistry.

Graphical abstract: Asymmetric 18F-fluorination for applications in positron emission tomography
From the themed collection: Global challenges: Health & Food
Open Access Minireview

Palladium: a future key player in the nanomedical field?

Palladium nanostructures with therapeutic potential are emerging as innovative tools in the nanomedical field.

Graphical abstract: Palladium: a future key player in the nanomedical field?
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

In vitro upconverting/downshifting luminescent detection of tumor markers based on Eu3+-activated core–shell–shell lanthanide nanoprobes

We demonstrate the successful use of Eu3+-activated core–shell–shell nanoprobes for in vitro upconverting/downshifting luminescent detection of a cancer biomarker of alpha-fetoprotein.

Graphical abstract: In vitro upconverting/downshifting luminescent detection of tumor markers based on Eu3+-activated core–shell–shell lanthanide nanoprobes
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery

The sequence of the virulence factor LecB differs significantly between the evolutionarily diverged PAO1- or PA14-like strains and can serve as marker for strain classification. Despite these variations, its comparable ligand selectivity makes LecB a highly promising target for anti-virulence therapy.

Graphical abstract: The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Comprehensive multiphase NMR applied to a living organism

Comprehensive Multiphase NMR provides an overview as to all components (liquids, gels, solids) in a living organism.

Graphical abstract: Comprehensive multiphase NMR applied to a living organism
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites

We show that two distinct mechanisms, FRET and MEF, of metallic nanoparticles can be finely tuned by a ligand–receptor interaction, producing a nanocomposite with an enhanced ROS production for targeted imaging and multimodal therapy.

Graphical abstract: Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

A quadrupolar two-photon fluorescent probe for in vivo imaging of amyloid-β plaques

A quadrupolar two-photon fluorescent probe for in vivo imaging of amyloid-β plaques is reported.

Graphical abstract: A quadrupolar two-photon fluorescent probe for in vivo imaging of amyloid-β plaques
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment

The efficacy of DOX·HCl against drug resistant human breast cancer cells is enhanced in the presence of a water-soluble pillar[6]arene (WP6) due to the inhibition of ATP hydrolysis upon formation of WP6⊃ATP in cells, providing a novel strategy to overcome multidrug resistance.

Graphical abstract: Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone

In this manuscript, we describe modification of Cys-residues in peptides and proteins in aqueous solvents via aromatic nucleophilic substitution (SNAr) with perfluoroarenes (fAr).

Graphical abstract: Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes

Structure-based design and syntheses of potent and highly selective BACE2 inhibitors are described.

Graphical abstract: Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Improvement of enzyme-linked immunosorbent assay for the multicolor detection of biomarkers

An activatable graphene-based nanoprobe is used to develop a multicolor immunosorbent assay for the detection of tumor protein biomarkers.

Graphical abstract: Improvement of enzyme-linked immunosorbent assay for the multicolor detection of biomarkers
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

A pillar[5]arene-based [2]rotaxane lights up mitochondria

Here we integrate diagnostic and therapeutic agents into a mitochondria-targeting [2]rotaxane, which can be utilized as a drug delivery platform to conjugate anticancer drugs to prepare prodrugs for efficient targeted drug delivery.

Graphical abstract: A pillar[5]arene-based [2]rotaxane lights up mitochondria
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Whipped oil stabilised by surfactant crystals

We describe a protocol for preparing very stable air-in-oil foams containing surfactant crystals starting from a one-phase solution of a fatty acid in a vegetable oil. On cooling, plate-like crystals form which adsorb at air bubble surfaces after aeration of the mixture. Such foams can be destabilised by gradual warming leading to crystal melting and bubble coalescence.

Graphical abstract: Whipped oil stabilised by surfactant crystals
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Conjugating a groove-binding motif to an Ir(III) complex for the enhancement of G-quadruplex probe behavior

G-quadruplex groove binder benzo[d,e]isoquinoline was linked to a Ir(III) complex to generate a highly selective DNA probe.

Graphical abstract: Conjugating a groove-binding motif to an Ir(iii) complex for the enhancement of G-quadruplex probe behavior
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods

We report a standardized complex molecule diagnostic approach using collections of relevant drug-like molecules which we call chemistry informer libraries.

Graphical abstract: Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Structurally plastic peptide capsules for synthetic antimicrobial viruses

A conceptual design for artificial antimicrobial viruses is described.

Graphical abstract: Structurally plastic peptide capsules for synthetic antimicrobial viruses
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

A probe for the in situ monitoring of singlet oxygen generation during targeted theranostic photodynamic therapy is developed based on a photosensitizer with aggregation-induced emission (AIE) characteristics and conjugated to a fluorogenic rhodol dye via a singlet oxygen cleavable linker.

Graphical abstract: A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis

A selective quenched activity-based probe detects caspase-3 activity in the endoplasmic reticulum of cancerous cells during apoptosis.

Graphical abstract: A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles

The rise of hospital-acquired infections, also known as nosocomial infections, is a growing concern in intensive healthcare, causing the death of hundreds of thousands of patients and costing billions of dollars worldwide every year.

Graphical abstract: Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(I) complexes in A549 lung cancer cells

Ferrocenylated-Au(I) carbenes were designed, synthesized, and studied for their ability to generate reactive oxygen species and target antioxidant pathways via multiple mechanisms.

Graphical abstract: Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(i) complexes in A549 lung cancer cells
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid

Oxidation of a protein cysteine thiol to sulfenic acid, termed S-sulfenylation, is a reversible post-translational modification that plays a crucial role in regulating protein function and is correlated with disease states.

Graphical abstract: Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Accurate calculation of the absolute free energy of binding for drug molecules

Free energy calculations based on molecular dynamics and thermodynamic cycles accurately reproduce experimental affinities of diverse bromodomain inhibitors.

Graphical abstract: Accurate calculation of the absolute free energy of binding for drug molecules
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

A fully synthetic self-adjuvanting globo H-Based vaccine elicited strong T cell-mediated antitumor immunity

Fully synthetic, self-adjuvanting monophosphoryl lipid A–globo H conjugate elicited strong T cell-mediated immunity that could target and kill breast cancer.

Graphical abstract: A fully synthetic self-adjuvanting globo H-Based vaccine elicited strong T cell-mediated antitumor immunity
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Design, preparation, and selection of DNA-encoded dynamic libraries

DNA-encoded dynamic libraries (DEDLs) are realized by dynamic DNA hybridization and a novel equilibrium-locking mechanism.

Graphical abstract: Design, preparation, and selection of DNA-encoded dynamic libraries
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Target-fueled DNA walker for highly selective miRNA detection

We report a DNA walking biosensor that can realize the detection of let-7a with a detection limit of 58 fM and high selectivity for resolving one nucleotide variation.

Graphical abstract: Target-fueled DNA walker for highly selective miRNA detection
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Lab on a single microbead: an ultrasensitive detection strategy enabling microRNA analysis at the single-molecule level

A single microbead-based sensing platform has been developed, which enables the detection of microRNA at the single-molecule level.

Graphical abstract: Lab on a single microbead: an ultrasensitive detection strategy enabling microRNA analysis at the single-molecule level
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Photoelectrochemical device based on Mo-doped BiVO4 enables smart analysis of the global antioxidant capacity in food

An ultrasensitive Mo-doped BiVO4 composite was used to engineer a photoelectrochemical platform for the direct analysis of the global antioxidant capacity. Using this principle, an integrated device was successfully exploited for the “smart” monitoring of antioxidant-rich foodstuffs.

Graphical abstract: Photoelectrochemical device based on Mo-doped BiVO4 enables smart analysis of the global antioxidant capacity in food
From the themed collection: Global Energy Challenges: Hydrogen Energy
Open Access Edge Article

A cell-penetrating protein designed for bimodal fluorescence and magnetic resonance imaging

A protein-based fluorescence and magnetic resonance bimodal imaging probe was explored in vitro, in cells and in mice.

Graphical abstract: A cell-penetrating protein designed for bimodal fluorescence and magnetic resonance imaging
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Photoresponsive immunomagnetic nanocarrier for capture and release of rare circulating tumor cells

7-Aminocoumarin compound was synthesized and used as phototrigger to cage EpCAM-antibody to construct a photocontrolled CTCs capture and release system.

Graphical abstract: Photoresponsive immunomagnetic nanocarrier for capture and release of rare circulating tumor cells
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Fluorescent carbon dot–molecular salt hydrogels

We report the incorporation of functionalised carbon nanodots within a low molecular weight salt hydrogel enhancing the gelation and fluorescence properties of both the gel and carbon nanomaterial.

Graphical abstract: Fluorescent carbon dot–molecular salt hydrogels
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

The medicinal thiosulfinates from garlic and Petiveria are not radical-trapping antioxidants in liposomes and cells, but lipophilic analogs are

The radical-trapping antioxidant (RTA) activities of allicin and petivericin, thiosulfinates widely believed responsible for the medicinal properties of garlic and Petiveria, were determined in phosphatidylcholine lipid bilayers and mammalian cell culture.

Graphical abstract: The medicinal thiosulfinates from garlic and Petiveria are not radical-trapping antioxidants in liposomes and cells, but lipophilic analogs are
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Cell paintballing using optically targeted coacervate microdroplets

A dynamic holographic assembler was used to “paintball” stem cells with coacervate microdroplets loaded with protein, oligonucleotide or molecular dye.

Graphical abstract: Cell paintballing using optically targeted coacervate microdroplets
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

An iridium(III)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent

This is the first report of a metal complex that targets the BRD4-acylated histone protein-protein interaction (PPI).

Graphical abstract: An iridium(iii)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents

We report the rational design and photodynamic anticancer mechanism studies of iridium(III) complexes with pH-responsive singlet oxygen (1O2) production and lysosome-specific imaging properties.

Graphical abstract: Cyclometalated iridium(iii) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy

A supramolecular nanovehicle (denoted as SNV) was fabricated by encapsulating zinc phthalocyanine (ZnPc) and doxorubicin (DOX) into a copolymer (PVP-b-PAA-g-FA), so as to achieve systematic and targeted tumor imaging and therapy.

Graphical abstract: A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Heterometallic titanium–gold complexes inhibit renal cancer cells in vitro and in vivo

Heterometallic compounds as anticancer agents demonstrating in vivo potential for the first time. Titanocene–gold derivatives: promising candidates for renal cancer.

Graphical abstract: Heterometallic titanium–gold complexes inhibit renal cancer cells in vitro and in vivo
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

An inhibitor of ubiquitin conjugation and aggresome formation

An inhibitor of ubiquitin activating E1 enzyme inhibits ubiquitin conjugation and aggresome formation.

Graphical abstract: An inhibitor of ubiquitin conjugation and aggresome formation
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Selective glycoprotein detection through covalent templating and allosteric click-imprinting

A hierarchical bottom-up route exploiting reversible covalent interactions with boronic acids and so-called click chemistry for selective glycoprotein detection is described. The self-assembled and imprinted surfaces confer high binding affinities, nanomolar sensitivity, exceptional glycoprotein specificity and selectivity.

Graphical abstract: Selective glycoprotein detection through covalent templating and allosteric click-imprinting
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

HOCl can appear in the mitochondria of macrophages during bacterial infection as revealed by a sensitive mitochondrial-targeting fluorescent probe

HOCl can appear in the mitochondria of macrophages during bacterial infection as revealed by a new sensitive mitochondrial-targeting fluorescent probe.

Graphical abstract: HOCl can appear in the mitochondria of macrophages during bacterial infection as revealed by a sensitive mitochondrial-targeting fluorescent probe
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli

New antibiotics are required to treat bacterial infections and counteract the emergence of antibiotic resistance.

Graphical abstract: Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Convergent chemo-enzymatic synthesis of mannosylated glycopeptides; targeting of putative vaccine candidates to antigen presenting cells

Convergent chemo-enzymatic synthesis of mannosylated glycopeptides enhances uptake by human antigen presenting cells whilst preserving the immunogenicity of peptide epitopes.

Graphical abstract: Convergent chemo-enzymatic synthesis of mannosylated glycopeptides; targeting of putative vaccine candidates to antigen presenting cells
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics

Mitochondria-targeted AIE photosensitizers show multifunctions of targeted and image-guided combination chemotherapy and photodynamic therapy.

Graphical abstract: Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Luminescence switch-on detection of protein tyrosine kinase-7 using a G-quadruplex-selective probe

A novel luminescent G-quadruplex-selective iridium(III) complex was employed in a G-quadruplex-based detection assay for PTK7.

Graphical abstract: Luminescence switch-on detection of protein tyrosine kinase-7 using a G-quadruplex-selective probe
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

pH-responsive and switchable triplex-based DNA hydrogels

pH-responsive DNA hydrogels based on Hoogsteen CG·C+ or TA·T triplex structures undergo reversible pH-induced hydrogel/solution transitions.

Graphical abstract: pH-responsive and switchable triplex-based DNA hydrogels
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery

Supramolecularly engineered phospholipids and liposomes based on complementary hydrogen bonding of nucleosides have been developed.

Graphical abstract: Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Multiplexed detection of serological cancer markers with plasmon-enhanced Raman spectro-immunoassay

A plasmon-enhanced Raman spectroscopic assay has been developed for multiplexed detection of breast cancer markers—with high sensitivity and exquisite specificity, offering the potential of evaluating the breast cancer burden accurately.

Graphical abstract: Multiplexed detection of serological cancer markers with plasmon-enhanced Raman spectro-immunoassay
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Fiber-optic array using molecularly imprinted microspheres for antibiotic analysis

In this article we describe a new class of high-density optical microarrays based on molecularly imprinted microsphere sensors that directly incorporate specific recognition capabilities to detect enrofloxacin (ENRO), an antibiotic widely used for both human and veterinary applications.

Graphical abstract: Fiber-optic array using molecularly imprinted microspheres for antibiotic analysis
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia

Hyperthermia used as an adjuvant with chemotherapy is highly promising in the treatment of certain cancers.

Graphical abstract: In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Ratiometric detection of pH fluctuation in mitochondria with a new fluorescein/cyanine hybrid sensor

The first small-molecular ratiometric pH sensor with mitochondria targeting ability was constructed. With this sensor, the stimulated pHm fluctuation in MCF-7 cells was monitored via both fluorescence confocal microscopy and flow cytometry.

Graphical abstract: Ratiometric detection of pH fluctuation in mitochondria with a new fluorescein/cyanine hybrid sensor
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Highly stable and reusable imprinted artificial antibody used for in situ detection and disinfection of pathogens

We fabricate artificial antibodies based on imprinting technology and develop a sandwich ELISA for pathogen detection.

Graphical abstract: Highly stable and reusable imprinted artificial antibody used for in situ detection and disinfection of pathogens
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

A mechanically interlocked molecular system programmed for the delivery of an anticancer drug

The development of mechanically interlocked molecular systems programmed to operate autonomously in biological environments is an emerging field of research with potential medicinal applications.

Graphical abstract: A mechanically interlocked molecular system programmed for the delivery of an anticancer drug
Open Access Edge Article

A dual-response BODIPY-based fluorescent probe for the discrimination of glutathione from cystein and homocystein

By employing a dual response approach, distinguishable fluorescence signals are initiated by GSH-mediated and Cys/Hcy-induced cascade reactions, thus allowing selective detection.

Graphical abstract: A dual-response BODIPY-based fluorescent probe for the discrimination of glutathione from cystein and homocystein
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

The RAPTA pharmacophore was linked to beads to identify its biomolecular targets in cancer cells.

Graphical abstract: Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers

An oligoamide helix mimicking foldamer with well-defined conformation is shown to recognize its target protein hDM2 in a manner that depends upon the composition, spatial projection and stereochemistry of functional groups appended to the scaffold.

Graphical abstract: Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe

A novel luminescent G-quadruplex-selective iridium(III) complex was employed in a label-free G-quadruplex-based detection assay for hepatitis C virus NS3 helicase activity.

Graphical abstract: Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease

An in vivo chemical tool designed to target metal−Aβ complexes and modulate their activity was applied to the 5XFAD mouse model of Alzheimer’s disease (AD) demonstrating the involvement of metal−Aβ in AD pathology.

Graphical abstract: A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Photostick: a method for selective isolation of target cells from culture

A new method enables optical selection of one or more cells in culture via photochemical crosslinking to the culture dish.

Graphical abstract: Photostick: a method for selective isolation of target cells from culture
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated graphene electrodes

Dynamic tracking of pathogenic receptor expression with live cells is made possible by pyrenyl glycoanthraquinones decorated on graphene electrodes.

Graphical abstract: Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated graphene electrodes
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging

Fluorescent/phosphorescent dual-emissive conjugated polymer dots were designed and synthesized, ere used for tumor hypoxia sensing via ratiometric imaging and photoluminescence lifetime imaging.

Graphical abstract: Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

Mechanized monodisperse nano metal–organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered release capabilities were constructed for the first time as a new stimuli-responsive theranostic hybrid platform.

Graphical abstract: Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Mesoporous silica nanoparticles for 19F magnetic resonance imaging, fluorescence imaging, and drug delivery

We described perfluorocarbon encapsulated in mesoporous silica nanoparticles which enabled dual modal imaging (NIR/19F MRI) and drug delivery.

Graphical abstract: Mesoporous silica nanoparticles for 19F magnetic resonance imaging, fluorescence imaging, and drug delivery
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Design of an intelligent sub-50 nm nuclear-targeting nanotheranostic system for imaging guided intranuclear radiosensitization

MR/UCL bimodal imaging guided intranuclear radiosensitization was firstly achieved by an intelligent nuclear-targeting nanotheranostic system.

Graphical abstract: Design of an intelligent sub-50 nm nuclear-targeting nanotheranostic system for imaging guided intranuclear radiosensitization
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Encapsulation of Pt(IV) prodrugs within a Pt(II) cage for drug delivery

This report describes a novel strategy for delivery of adamantyl-functionalized payloads using a supramolecular system, with a focus on Pt(IV) prodrugs.

Graphical abstract: Encapsulation of Pt(iv) prodrugs within a Pt(ii) cage for drug delivery
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

Kinetically selective inhibitors of HDAC2 enhanced learning and memory in a CK-p25 mouse model of neurodegeneration.

Graphical abstract: Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

In vivo visible light-triggered drug release from an implanted depot

A visible light-degradable polymer allows on-demand in vivo photorelease of encapsulated dexamethasone from a subcutaneously implanted particle depot.

Graphical abstract: In vivo visible light-triggered drug release from an implanted depot
From the themed collection: Global challenges: Health & Food
Open Access Edge Article

Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium

Highly branched vinyl polymers (hyperbranched polydendrons), displaying combinations of dendritic and PEG end groups, have been synthesised using a mixed initiator approach. Nanoprecipitated polydendron particles have exhibited controlled permeation through a gut epithelium model.

Graphical abstract: Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium
From the themed collection: Global challenges: Health & Food
77 items - Showing page 1 of 2

About this collection

To address major issues facing our planet and humanity, now and in the future, researchers all over the world have increasingly focused their energy and resources on finding solutions to these global challenges.

We are delighted to present this collection of articles recently published in Chemical Science, highlighting some of the excellent work that tackles important challenges related to global health and food.

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