Fundamental developments in clinical infrared and Raman spectroscopy
Guest editors Matthew Baker and Karen Faulds introduce the Fundamental Developments in Clinical Infrared and Raman Spectroscopy issue of Chemical Society Reviews
Review Article
Quantum cascade lasers (QCLs) in biomedical spectroscopy
This review focuses on the recent applications of QCLs in mid-IR spectroscopy of clinically relevant samples.
Prospects for point-of-care pathogen diagnostics using surface-enhanced Raman scattering (SERS)
This review highlights recent advances in the application of surface-enhanced Raman scattering (SERS) in pathogen detection and discusses many of the challenges in moving this technology to the point-of-care (POC) arena.
Clinical instrumentation and applications of Raman spectroscopy
Clinical diagnostic devices based on Raman spectroscopy provide new sources of information that give insight about the state of health which can then be used to manage patient care.
Fundamental developments in infrared spectroscopic imaging for biomedical applications
This review covers the rapidly emerging field of infrared chemical imaging focussing on new advances in instrumentation and data acquisition.
Developing fibre optic Raman probes for applications in clinical spectroscopy
Raman spectroscopy has been shown by various groups over the last two decades to have significant capability in discriminating disease states in bodily fluids, cells and tissues.
Multiplex in vitro detection using SERS
This review focuses on the recent advances in SERS and its potential to detect multiple biomolecules in clinical samples.
Developing and understanding biofluid vibrational spectroscopy: a critical review
Biofluid vibrational spectroscopy, a promising tool for rapid disease diagnosis.
Raman and infra-red microspectroscopy: towards quantitative evaluation for clinical research by ratiometric analysis
We demonstrate how ratioing spectral bands can circumvent experimental artefacts, and present a library of ratios from the biomedical literature.
Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications
An overview about the instrumentation for spontaneous and coherent Raman scattering microscopic imaging is given with a focus on recent developments.
Attenuated total reflection Fourier-transform infrared (ATR-FTIR) imaging of tissues and live cells
Recent advances and emerging applications of ATR-FTIR spectroscopic imaging for analysis of biomedical samples have been reviewed.
Spectral pre and post processing for infrared and Raman spectroscopy of biological tissues and cells
This review presents the current understanding of the factors influencing the quality of spectra recorded and the pre-processing steps commonly employed to improve on spectral quality, as well as some of the most common techniques for classification and analysis of the spectral data for biomedical applications.
The importance of hydration and DNA conformation in interpreting infrared spectra of cells and tissues
The effect of hydration on cells and tissues modifies the DNA conformation leading to dramatic changes in the FTIR spectra, which has important implications in disease diagnosis.
Tutorial Review
Development of deep subsurface Raman spectroscopy for medical diagnosis and disease monitoring
The advent of non-invasive deep Raman techniques heralds the emergence of novel diagnostic and disease monitoring methods.
About this collection
Chemical Society Reviews is delighted to present a themed issue guest edited by Matthew Baker and Karen Faulds which highlights the fundamental developments in clinical applications of vibrational spectroscopy. This issue focuses on the different vibrational techniques used to gain clinical information from biological samples, as well as on the development of new technologies and methods to understand, evaluate and interpret the collected information. New articles will be added to this collection as they are published.