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Themed collection Recent HOT articles

139 items - Showing page 1 of 2
Communication

Ratiometric fluorescence monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine

A novel ratiometric fluorescence assay for cerebral Cu2+ has been developed based on coumarin-labeled single-stranded DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine.

Graphical abstract: Ratiometric fluorescence monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine
From the themed collection: Recent HOT articles
Communication

C–H oxidation and chelation of a dipyrromethane mediated rapid colorimetric naked-eye Cu(II) chemosensor

Selective C–H oxidation and chelation of DPMs mediated by copper is demonstrated and utilized in the development of a rapid colorimetric naked-eye Cu(II) chemosensor.

Graphical abstract: C–H oxidation and chelation of a dipyrromethane mediated rapid colorimetric naked-eye Cu(ii) chemosensor
From the themed collection: Recent HOT articles
Communication

Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics

Lipid exchange among citrem nanoparticles and an ethanol micellar solution containing soy phosphatidylcholine was investigated in situ by coupling small angle X-ray scattering with a microfluidic device.

Graphical abstract: Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics
From the themed collection: Recent HOT articles
Open Access Communication

Measuring the effects of fractionated radiation therapy in a 3D prostate cancer model system using SERS nanosensors

Using Surface Enhanced Raman Spectroscopy to measure cell death caused by radiation in a 3D model of prostate cancer.

Graphical abstract: Measuring the effects of fractionated radiation therapy in a 3D prostate cancer model system using SERS nanosensors
From the themed collection: Recent HOT articles
Communication

Sensitive SERS nanotags for use with 1550 nm (retina-safe) laser excitation

1550 nm SERS nanotags have been developed to provide effective SERS with picomolar detection limits when excited with a retina-safe laser.

Graphical abstract: Sensitive SERS nanotags for use with 1550 nm (retina-safe) laser excitation
From the themed collection: Recent HOT articles
Communication

The importance of correcting for variable probe–sample interactions in AFM-IR spectroscopy: AFM-IR of dried bacteria on a polyurethane film

Interplay between AFM-IR probe – sample interactions and signal transduction for bacteria – PU bilayer.

Graphical abstract: The importance of correcting for variable probe–sample interactions in AFM-IR spectroscopy: AFM-IR of dried bacteria on a polyurethane film
From the themed collection: Recent HOT articles
Communication

A visual and reversible assay for temperature using thioflavin T-doped lanthanide/nucleotide coordination polymers

A convenient one-step approach has been developed to make thermo-sensitive lanthanide coordination polymer nanoparticles (LCPNs) doped with thioflavin T.

Graphical abstract: A visual and reversible assay for temperature using thioflavin T-doped lanthanide/nucleotide coordination polymers
From the themed collection: Recent HOT articles
Communication

Rapid discrimination of bacteria using a miniature mass spectrometer

Bacteria colonies were analyzed using paper spray ionization coupled with a portable mass spectrometer.

Graphical abstract: Rapid discrimination of bacteria using a miniature mass spectrometer
From the themed collection: Recent HOT articles
Communication

Quantitative carbon detector for enhanced detection of molecules in foods, pharmaceuticals, cosmetics, flavors, and fuels

Analysis of trace compounds, such as pesticides and other contaminants, within consumer products, fuels, and the environment requires quantification of increasingly complex mixtures of difficult-to-quantify compounds.

Graphical abstract: Quantitative carbon detector for enhanced detection of molecules in foods, pharmaceuticals, cosmetics, flavors, and fuels
From the themed collection: Recent HOT articles
Communication

First airborne pathogen direct analysis system

This is the first portable “sample to answer” system for the rapid detection of pathogenic bacteria in air.

Graphical abstract: First airborne pathogen direct analysis system
From the themed collection: Recent HOT articles
Communication

Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide

Imaging hydrogen sulfide (H2S) at the subcellular resolution will greatly improve the understanding of functions of this signaling molecule.

Graphical abstract: Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide
From the themed collection: Recent HOT articles
Paper

Dynamic sandwich-type electrochemical assay for protein quantification and protein–protein interaction

A versatile and sensitive electrochemical method for protein–protein interaction study based on DNAzyme has been proposed.

Graphical abstract: Dynamic sandwich-type electrochemical assay for protein quantification and protein–protein interaction
From the themed collection: Recent HOT articles
Paper

A new lateral-flow immunochromatographic strip combined with quantum dot nanobeads and gold nanoflowers for rapid detection of tetrodotoxin

A sensitive, rapid detection strip based on nanoparticles for tetrodotoxin detection was developed and it meets all testing requirements.

Graphical abstract: A new lateral-flow immunochromatographic strip combined with quantum dot nanobeads and gold nanoflowers for rapid detection of tetrodotoxin
From the themed collection: Recent HOT articles
Paper

A ratiometric electrochemical strategy for sensitive determination of Furin activity based on dual signal amplification and antifouling nanosurfaces

Developing a sensitive and accurate method for Furin activity is still the bottleneck for understanding the role played by Furin in cell-surface systems and even in Alzheimer's disease.

Graphical abstract: A ratiometric electrochemical strategy for sensitive determination of Furin activity based on dual signal amplification and antifouling nanosurfaces
From the themed collection: Recent HOT articles
Paper

A fully integrated microfluidic platform for highly sensitive analysis of immunochemical parameters

A fully integrated cartridge for highly sensitive immunochemical analysis of cardiac markers with new microfluidic functionalities is presented.

Graphical abstract: A fully integrated microfluidic platform for highly sensitive analysis of immunochemical parameters
From the themed collection: Recent HOT articles
Paper

Deep convolutional neural networks for Raman spectrum recognition: a unified solution

Classification of unprocessed Raman spectra using a convolutional neural network.

Graphical abstract: Deep convolutional neural networks for Raman spectrum recognition: a unified solution
From the themed collection: Recent HOT articles
Paper

Analysis of human gliomas by swab touch spray-mass spectrometry: applications to intraoperative assessment of surgical margins and presence of oncometabolites

Touch spray mass spectrometry using medical swabs has potential intraoperative application in quickly identifying the disease state of the tissue and in better characterizing resection margins.

Graphical abstract: Analysis of human gliomas by swab touch spray-mass spectrometry: applications to intraoperative assessment of surgical margins and presence of oncometabolites
From the themed collection: Recent HOT articles
Paper

Microelectrode generator–collector systems for electrolytic titration: theoretical and practical considerations

A novel analysis of generator–collector devices is presented and applied to electrolytic acid–base titration.

Graphical abstract: Microelectrode generator–collector systems for electrolytic titration: theoretical and practical considerations
From the themed collection: Recent HOT articles
Paper

Preparation and application of a poly (ionic liquid)-based molecularly imprinted polymer for multiple monolithic fiber solid-phase microextraction of phenolic acids in fruit juice and beer samples

A novel poly (ionic liquid)-based molecularly imprinted polymer for multiple monolithic fiber solid-phase microextraction of phenolic acids.

Graphical abstract: Preparation and application of a poly (ionic liquid)-based molecularly imprinted polymer for multiple monolithic fiber solid-phase microextraction of phenolic acids in fruit juice and beer samples
From the themed collection: Recent HOT articles
Paper

A single-round selection of selective DNA aptamers for mammalian cells by polymer-enhanced capillary transient isotachophoresis

A single-round DNA aptamer selection for mammalian cells was successfully achieved for the first time using a capillary electrophoresis (CE)-based methodology.

Graphical abstract: A single-round selection of selective DNA aptamers for mammalian cells by polymer-enhanced capillary transient isotachophoresis
From the themed collection: Recent HOT articles
Paper

Alkaline peroxidase activity of cupric oxide nanoparticles and its modulation by ammonia

Based on the ammonia-modulated alkaline peroxidase-like activity of CuO nanoparticles, a fluorescent sensor for urea and urease was developed.

Graphical abstract: Alkaline peroxidase activity of cupric oxide nanoparticles and its modulation by ammonia
From the themed collection: Recent HOT articles
Paper

New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies

A new penta-saccharide-bearing tripod amphiphile (TPS-E10L) conferred enhanced stability to β2 adrenergic receptor (β2AR) and its Gs complex.

Graphical abstract: New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies
From the themed collection: Recent HOT articles
Paper

A ratiometric fluorescent pH probe based on keto–enol tautomerization for imaging of living cells in extreme acidity

A ratiometric fluorescent pH probe (DDXC) has been developed for extreme acidity, the sensing mechanism of which is based on the reversible protonation of the carbonyl oxygen followed by keto–enol tautomerization.

Graphical abstract: A ratiometric fluorescent pH probe based on keto–enol tautomerization for imaging of living cells in extreme acidity
From the themed collection: Recent HOT articles
Paper

Magnetic nanoparticle-enhanced surface plasmon resonance biosensor for extracellular vesicle analysis

Sensitive analysis of small lipid extracellular vesicles by using a grating-coupled surface plasmon resonance biosensor.

Graphical abstract: Magnetic nanoparticle-enhanced surface plasmon resonance biosensor for extracellular vesicle analysis
From the themed collection: Recent HOT articles
Paper

Sensitive and selective detection of the p53 gene based on a triple-helix magnetic probe coupled to a fluorescent liposome hybridization assembly via rolling circle amplification

Developing a sensitive and selective sensing platform for the p53 gene and its mutation analysis is essential and may aid in early cancer screening and assessment of prognosis.

Graphical abstract: Sensitive and selective detection of the p53 gene based on a triple-helix magnetic probe coupled to a fluorescent liposome hybridization assembly via rolling circle amplification
From the themed collection: Recent HOT articles
Paper

Integrating multiple fitting regression and Bayes decision for cancer diagnosis with transcriptomic data from tumor-educated blood platelets

The application of machine learning in cancer diagnostics has shown great promise and is of importance in clinic settings.

Graphical abstract: Integrating multiple fitting regression and Bayes decision for cancer diagnosis with transcriptomic data from tumor-educated blood platelets
From the themed collection: Recent HOT articles
Paper

An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening

We have developed a next generation aptamer-based bio-barcode (ABC) assay to detect cytochrome-c (Cyto-c), a cell death marker released from cancer cells, for anti-cancer drug screening.

Graphical abstract: An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
From the themed collection: Recent HOT articles
Paper

Onsite cavity enhanced Raman spectrometry for the investigation of gas exchange processes in the Earth's critical zone

Cavity enhanced Raman spectrometry is a sensitive technique which is capable of continuous onsite analysis of multiple soil gases below-ground.

Graphical abstract: Onsite cavity enhanced Raman spectrometry for the investigation of gas exchange processes in the Earth's critical zone
From the themed collection: Recent HOT articles
Paper

Microchip electrophoresis utilizing an in situ photopolymerized Phos-tag binding polyacrylamide gel for specific entrapment and analysis of phosphorylated compounds

A method was developed for the specific entrapment and separation of phosphorylated compounds using a Phos-tag polyacrylamide gel fabricated at the channel crossing point of a microfluidic electrophoresis chip.

Graphical abstract: Microchip electrophoresis utilizing an in situ photopolymerized Phos-tag binding polyacrylamide gel for specific entrapment and analysis of phosphorylated compounds
From the themed collection: Recent HOT articles
Paper

A pneumatically assisted nanospray desorption electrospray ionization source for increased solvent versatility and enhanced metabolite detection from tissue

Pneumatically assisted nano-DESI offers improved sensitivity for metabolite species by 1–3 orders of magnitude through more complete desolvation and reduced ionization suppression.

Graphical abstract: A pneumatically assisted nanospray desorption electrospray ionization source for increased solvent versatility and enhanced metabolite detection from tissue
From the themed collection: Recent HOT articles
Paper

An ultrasensitive enzyme-free electrochemical immunosensor based on redox cycling amplification using methylene blue

An enzyme-free immunosensor based on methylene blue redox cycling was developed for ultrasensitive analytical measurements in plasma and whole blood samples.

Graphical abstract: An ultrasensitive enzyme-free electrochemical immunosensor based on redox cycling amplification using methylene blue
From the themed collection: Recent HOT articles
Paper

A model derived from hydrodynamic simulations for extracting the size of spherical particles from the quartz crystal microbalance

A model derived from hydrodynamic simulations is presented for extracting the size of adsorbed nanoparticles in QCM-D measurements, and is applicable to both low and high surface coverage regimes.

Graphical abstract: A model derived from hydrodynamic simulations for extracting the size of spherical particles from the quartz crystal microbalance
From the themed collection: Recent HOT articles
Paper

Spatial and spectral resolution of carbonaceous material from hematite (α-Fe2O3) using multivariate curve resolution-alternating least squares (MCR-ALS) with Raman microspectroscopic mapping: implications for the search for life on Mars

We report a novel application of multivariate analysis with Raman microspectroscopic mapping to enhance the search for life on Mars.

Graphical abstract: Spatial and spectral resolution of carbonaceous material from hematite (α-Fe2O3) using multivariate curve resolution-alternating least squares (MCR-ALS) with Raman microspectroscopic mapping: implications for the search for life on Mars
From the themed collection: Recent HOT articles
Paper

A surface plasmon field-enhanced fluorescence reversible split aptamer biosensor

Surface plasmon-enhanced fluorescence for the readout of a assay with low affinity split aptamer.

Graphical abstract: A surface plasmon field-enhanced fluorescence reversible split aptamer biosensor
From the themed collection: Recent HOT articles
Paper

Solvent gradient electrospray for laser ablation electrospray ionization mass spectrometry

Changing spray solution polarity in a gradient electrospray improves molecular coverage in LAESI-MS analysis of biological samples.

Graphical abstract: Solvent gradient electrospray for laser ablation electrospray ionization mass spectrometry
From the themed collection: Recent HOT articles
Paper

Sandwiched gold/PNIPAm/gold microstructures for smart plasmonics application: towards the high detection limit and Raman quantitative measurements

A smart plasmonic SERS platform, comprising a layer of a stimuli-responsive polymer sandwiched between two gold layers, is reported.

Graphical abstract: Sandwiched gold/PNIPAm/gold microstructures for smart plasmonics application: towards the high detection limit and Raman quantitative measurements
From the themed collection: Recent HOT articles
Paper

An implantable multimodal sensor for oxygen, neurotransmitters, and electrophysiology during spreading depolarization in the deep brain

An implantable 5 μm sensor is characterized for simultaneous measurements of oxygen, dopamine, and electrophysiology in the deep brain during spreading depolarizations.

Graphical abstract: An implantable multimodal sensor for oxygen, neurotransmitters, and electrophysiology during spreading depolarization in the deep brain
From the themed collection: Recent HOT articles
Paper

Validation of a membrane touch biosensor for the qualitative detection of IgG class antibodies to herpes simplex virus type 2

A 1920s dead-stop end-point titration technique revisited for blood antibody analysis.

Graphical abstract: Validation of a membrane touch biosensor for the qualitative detection of IgG class antibodies to herpes simplex virus type 2
From the themed collection: Recent HOT articles
Paper

Immunoassay quantification using surface-enhanced fluorescence (SEF) tags

A fluorescence immunoassay based on surface-enhanced fluorescence (SEF) was introduced. The use of SEF tags may provide advantages over regular organic dyes for biomedical assays.

Graphical abstract: Immunoassay quantification using surface-enhanced fluorescence (SEF) tags
From the themed collection: Recent HOT articles
Paper

Limited proteolysis in porous membrane reactors containing immobilized trypsin

Trypsin-containing membranes effect limited digestion to identify facile digestion sites in protein structures.

Graphical abstract: Limited proteolysis in porous membrane reactors containing immobilized trypsin
From the themed collection: Recent HOT articles
Paper

Quantitative isotopic measurements of gas-phase alcohol mixtures using a broadly tunable swept external cavity quantum cascade laser

Isotopic quantification of gas-phase mixtures is performed using a swept external cavity quantum cascade laser and broadband infrared spectral analysis.

Graphical abstract: Quantitative isotopic measurements of gas-phase alcohol mixtures using a broadly tunable swept external cavity quantum cascade laser
From the themed collection: Recent HOT articles
Paper

Ultra-low fouling methylimidazolium modified surfaces for the detection of HER2 in breast cancer cell lysates

We synthesized novel ultra-low fouling ionic liquids and demonstrated their use with surface plasmon resonance (SPR) sensing for the analysis of HER2 in breast cancer cell lysates.

Graphical abstract: Ultra-low fouling methylimidazolium modified surfaces for the detection of HER2 in breast cancer cell lysates
From the themed collection: Recent HOT articles
Paper

Unique capabilities of AC frequency scanning and its implementation on a Mars Organic Molecule Analyzer linear ion trap

AC frequency scanning in quadrupole ion traps enables unique scan modes.

Graphical abstract: Unique capabilities of AC frequency scanning and its implementation on a Mars Organic Molecule Analyzer linear ion trap
From the themed collection: Recent HOT articles
Paper

Colorimetric and electrochemical quantification of global DNA methylation using a methyl cytosine-specific antibody

We report a simple colorimetric (naked-eye) and electrochemical method for the rapid, sensitive and specific quantification of global methylation levels using only 25 ng of input DNA.

Graphical abstract: Colorimetric and electrochemical quantification of global DNA methylation using a methyl cytosine-specific antibody
From the themed collection: Recent HOT articles
Open Access Paper

LILY-lipidome isotope labeling of yeast: in vivo synthesis of 13C labeled reference lipids for quantification by mass spectrometry

Quantification is an essential task in comprehensive lipidomics studies challenged by the high number of lipids, their chemical diversity and their dynamic range (up to 7 orders of magnitude) of the lipidome.

Graphical abstract: LILY-lipidome isotope labeling of yeast: in vivo synthesis of 13C labeled reference lipids for quantification by mass spectrometry
From the themed collection: Recent HOT articles
Paper

Refinement of insulator-based dielectrophoresis

The development of a new insulator for higher resolution separations using dielectrophoresis.

Graphical abstract: Refinement of insulator-based dielectrophoresis
From the themed collection: Recent HOT articles
Paper

Infrared imaging of high density protein arrays

We propose in this paper that protein microarrays could be analysed by infrared imaging in place of enzymatic or fluorescence labelling.

Graphical abstract: Infrared imaging of high density protein arrays
From the themed collection: Recent HOT articles
Paper

High-index {hk0} faceted platinum concave nanocubes with enhanced peroxidase-like activity for an ultrasensitive colorimetric immunoassay of the human prostate-specific antigen

A novel colorimetric immunoassay is designed for the ultrasensitive detection of the human prostate-specific antigen (PSA) by using a unique type of nanolabel – high-index {hk0} faceted platinum concave nanocubes.

Graphical abstract: High-index {hk0} faceted platinum concave nanocubes with enhanced peroxidase-like activity for an ultrasensitive colorimetric immunoassay of the human prostate-specific antigen
From the themed collection: Recent HOT articles
Paper

A microneedle biosensor for minimally-invasive transdermal detection of nerve agents

A microneedle array based biosensor for minimally invasive electrochemical monitoring of organophosphate (OP) nerve agents under the skin.

Graphical abstract: A microneedle biosensor for minimally-invasive transdermal detection of nerve agents
From the themed collection: Recent HOT articles
Paper

Collapse of chain anadiplosis-structured DNA nanowires for highly sensitive colorimetric assay of nucleic acids

In this work, we have proposed a chain anadiplosis-structured DNA nanowire by using two well-defined assembly strands (AS1 and AS2).

Graphical abstract: Collapse of chain anadiplosis-structured DNA nanowires for highly sensitive colorimetric assay of nucleic acids
From the themed collection: Recent HOT articles
Paper

DNA biosensing with 3D printing technology

Herein, the potential of employing 3D printing technology for the detection of DNA hybridization is assessed.

Graphical abstract: DNA biosensing with 3D printing technology
From the themed collection: Recent HOT articles
Paper

Characterization of lectin binding affinities via direct LC-MS profiling: implications for glycopeptide enrichment and separation strategies

Determining the affinity between a lectin and its target glycans is an important goal, both for understanding the biological functions of a given lectin as well as enabling the use of that lectin for targeted enrichment of glycosylated species from complex samples.

Graphical abstract: Characterization of lectin binding affinities via direct LC-MS profiling: implications for glycopeptide enrichment and separation strategies
From the themed collection: Recent HOT articles
Paper

Orientational binding modes of reporters in a viral-nanoparticle lateral flow assay

Capture of ellipsoidal viral-nanoparticle reporters in a model lateral flow assay is enhanced by behavior of the anisotropic reporters in the local flow field.

Graphical abstract: Orientational binding modes of reporters in a viral-nanoparticle lateral flow assay
From the themed collection: Recent HOT articles
Open Access Paper

Accurate quantification of apoptosis progression and toxicity using a dielectrophoretic approach

A rapid, low-cost and label-free method of cell analysis compares favorably to Annexin-V, MTT and trypan blue for assessment of apoptosis and IC50.

Graphical abstract: Accurate quantification of apoptosis progression and toxicity using a dielectrophoretic approach
From the themed collection: Recent HOT articles
Paper

Detection of evoked acetylcholine release in mouse brain slices

The study of transmitter interactions in the brain requires methodology to detect stimulus-driven neurotransmitter release. This report introduces an enzyme-coated 7 μm carbon-fiber microelectrode used with fast-scan cyclic voltammetry to detect evoked acetylcholine release in mouse brain slices.

Graphical abstract: Detection of evoked acetylcholine release in mouse brain slices
From the themed collection: Recent HOT articles
Paper

Correcting the fundamental ion mobility equation for field effects

Cross sections measured by ion mobility spectrometry are corrected for collision frequency and cooling/heating-controlled momentum transfer.

Graphical abstract: Correcting the fundamental ion mobility equation for field effects
From the themed collection: Recent HOT articles
Paper

Microchip in situ electrosynthesis of silver metallic oxide clusters for ultra-FAST detection of galactose in galactosemic newborns’ urine samples

This work describes for the first time the coupling of microfluidic chips (MC) to electrosynthetized silver metallic oxide clusters (AgMOCs).

Graphical abstract: Microchip in situ electrosynthesis of silver metallic oxide clusters for ultra-FAST detection of galactose in galactosemic newborns’ urine samples
From the themed collection: Recent HOT articles
Paper

Thin-layer voltammetry of soluble species on screen-printed electrodes: proof of concept

Thin-layer diffusion conditions were accomplished on screen-printed electrodes by placing a controlled-weight onto the cast solution and allowing for its natural spreading.

Graphical abstract: Thin-layer voltammetry of soluble species on screen-printed electrodes: proof of concept
From the themed collection: Recent HOT articles
Paper

Microfluidic array for simultaneous detection of DNA oxidation and DNA-adduct damage

A microfluidic electrochemical sensor array detects DNA oxidation and adduct formation for a fast genotoxicity chemistry screen for test compounds.

Graphical abstract: Microfluidic array for simultaneous detection of DNA oxidation and DNA-adduct damage
From the themed collection: Recent HOT articles
Paper

Macro-to-micro interfacing to microfluidic channels using 3D-printed templates: application to time-resolved secretion sampling of endocrine tissue

3D-printed templates enabled sculpting of design-specific fluidic reservoirs into the bulk substrate of microfluidic devices used for culture and time-resolved sampling of islets and adipose tissue explants.

Graphical abstract: Macro-to-micro interfacing to microfluidic channels using 3D-printed templates: application to time-resolved secretion sampling of endocrine tissue
From the themed collection: Recent HOT articles
Open Access Paper

Gas-phase microsolvation of ubiquitin: investigation of crown ether complexation sites using ion mobility-mass spectrometry

The influence of side chain to backbone interactions on the gas-phase structure of ubiquitin and ubiquitin lysine-to-arginine mutants was analysed.

Graphical abstract: Gas-phase microsolvation of ubiquitin: investigation of crown ether complexation sites using ion mobility-mass spectrometry
From the themed collection: Recent HOT articles
Paper

Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry

Novel antibodies to differentiate veterinary BoNTs by immunoassays and mass spectrometry.

Graphical abstract: Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry
From the themed collection: Recent HOT articles
Open Access Paper

Investigating non-specific binding to chemically engineered sensor surfaces using liposomes as models

Clever surface engineering strategies lead to the minimization of non-specific binding of liposomes to sensor substrates.

Graphical abstract: Investigating non-specific binding to chemically engineered sensor surfaces using liposomes as models
From the themed collection: Recent HOT articles
Paper

The efficiencies of resonant and nonresonant multiphoton ionization in the femtosecond region

Multiphoton ionization processes studied using a tunable femtosecond laser.

Graphical abstract: The efficiencies of resonant and nonresonant multiphoton ionization in the femtosecond region
From the themed collection: Recent HOT articles
Paper

Assembling substrate-less plasmonic metacrystals at the oil/water interface for multiplex ultratrace analyte detection

Designing substrate-less plasmonic metacrystals for the multiplex ultratrace detection of analytes from both organic and aqueous phases.

Graphical abstract: Assembling substrate-less plasmonic metacrystals at the oil/water interface for multiplex ultratrace analyte detection
From the themed collection: Recent HOT articles
Paper

In solution SERS sensing using mesoporous silica-coated gold nanorods

Mesoporous silica-coated gold nanorods (AuNR@MS) act as a colloidally stable Raman sensing platform with a built-in analyte size cutoff.

Graphical abstract: In solution SERS sensing using mesoporous silica-coated gold nanorods
From the themed collection: Recent HOT articles
Open Access Paper

Biomolecular environment, quantification, and intracellular interaction of multifunctional magnetic SERS nanoprobes

Multifunctional composite nanoprobes, Ag–Magnetite and Au–Magnetite, were manipulated in fibroblast cells and characterized using SERS, LA-ICP-MS, and nanotomography.

Graphical abstract: Biomolecular environment, quantification, and intracellular interaction of multifunctional magnetic SERS nanoprobes
From the themed collection: Recent HOT articles
Paper

SERS speciation of the electrochemical oxidation–reduction of riboflavin

The electrochemical oxidation and reduction of riboflavin is detected and characterized by SERS.

Graphical abstract: SERS speciation of the electrochemical oxidation–reduction of riboflavin
From the themed collection: Recent HOT articles
Paper

Expanding neurochemical investigations with multi-modal recording: simultaneous fast-scan cyclic voltammetry, iontophoresis, and patch clamp measurements

Simultaneous patch clamp and fast-scan cyclic voltammetry measurements were performed to monitor cell behavior during iontophoretic drug delivery.

Graphical abstract: Expanding neurochemical investigations with multi-modal recording: simultaneous fast-scan cyclic voltammetry, iontophoresis, and patch clamp measurements
From the themed collection: Recent HOT articles
Paper

Pseudo isobaric peptide termini labelling for relative proteome quantification by SWATH MS acquisition

The SWATH-pseudo-IPTL method is a promising strategy in quantitative proteomics, and has been efficiently applied in biological studies due to its high quantitative accuracy.

Graphical abstract: Pseudo isobaric peptide termini labelling for relative proteome quantification by SWATH MS acquisition
From the themed collection: Recent HOT articles
139 items - Showing page 1 of 2

About this collection

This themed collection features original research articles published in Analyst marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.

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