Themed collection Bioanalytical Sensors

This minireview highlights the developments in optical chemosensors from 2014 to 2016 that utilise the boronic acid interaction with polyols or Lewis bases.

In this mini review, we will provide a brief introduction focusing on the current applications of single plasmonic nanoparticle-based sensors using DFM, including the detection of molecules, the real-time monitoring of chemical/electrochemical reactions and the imaging of living cells.

The response is what makes a sensor. In this review the methods for characterizing the response are laid out.

A review of the uses of saliva biomarkers, detection methods and requirements for new biomarkers.

High-throughput profiling/sensing of nucleic acids has recently emerged as a highly promising strategy for the early diagnosis and improved prognosis of a broad range of pathologies, most notably cancer. The review highlights some of the most promising strategies for electrochemical sensing of microRNA biomarkers.

Graphene-based aptasensors exhibit wide applications for the biomedical detection of DNA, proteins, small molecules, viruses, bacteria, and cells.

This review highlights advances and trends in microfluidic techniques for selecting and characterizing nucleic acid aptamers.

This critical review provides an overview of sensitivity-enhancement strategies and a systematic, quantitative analysis of field-effect transistor (IS-FET/BioFET) sensor literature.

Principles and signal generation mechanisms for both homogenous and heterogeneous proteases assays are reviewed in this article.

A new design was developed for detection of dopamine using a boronic acid based amphiphile at aqueous–liquid crystal interface. The detection was highly enhanced in presence of gold nanoparticles.

A new immunoassay was designed for the detection of disease-related biomarkers (alpha-fetoprotein, AFP, as a model), coupling an aluminium (Al)/Prussian blue-based electrochromic display with a digital multimeter readout.

Insulin sensor cells for the direct measurement of insulin secreted from single living pancreatic β cells were developed.

A widefield FD-FLIM system with fast acquisition speed is utilized to accurately characterize oxygen gradient distributions within microfluidic devices.

A novel 1-oxo-1H-phenalene-2,3-dicarbonitrile (OPD)-based fluorescent probe was developed to sense and image GSH in HeLa cells, different imatinib-resistant K562 cells, D. magna and zebrafish embryos.

In this work, we demonstrate the potential use of SPRi for secretion-monitoring of pancreatic islets, small micro-organs that regulate glucose homeostasis in the body.

In this study, sulfur–nitrogen co-doped carbon nanoribbon (SNCNR) polymers with stable dual-emission fluorescence were synthesized using a one-step traditional hydrothermal method of 6-mercaptopurine in an aqueous methanol solution.

Here, we found that Thioflavin T (ThT) could specifically bind with a G-GGG unit (named as “Guanine Island”) in double stranded DNA (ds-DNA).

Scheme of the MnO₂ NP-mediated fluorescence turn-off-on process of CDs with MnO₂ NPs and GSH.

Preparation of peroxidase-mimic ZnFe₂O₄–carbon nanotube (CNT)–glucose oxidase (GOD) composite material for sensitive detection of glucose.

In this work, a sensitive and selective electrochemical aptasensor for detection of microcystin-LR was developed based on a dual signal amplification system consisted of a novel ternary composite and horseradish peroxidase.

A multiple signal amplification of a SERS biosensor was developed for sensitive detection of cTnI with the aid of GO/AuNP complexes.

Depicting fluorescence sensing of protamine and heparin based on aggregation and disaggregation of copper nanoclusters.

A simple and novel strategy for detection of AA and ALP via controlled generation of Ag NPs and selective recognition.

A facile Fe-doped carbon quantum dot based fluorescent sensor for dopamine sensing and bioimaging was constructed.

Herein, we developed a sensitive graphitic carbon nitride quantum dot (gCNQD)-based fluorescent strategy for β-amyloid peptide monomer (Aβ) determination down to the ng mL⁻¹ level for the first time.

A conjugated carbon-dot–tyrosinase bioprobe was first designed and applied for sensitive and selective dopamine detection in human serum.

Wearable biosensors are critical for enabling real-time and continuous health monitoring and disease management.

Selectivity in amperometric nitric oxide measurements was improved via controlling the shape of electrodeposited platinum nanostructures without any selective membranes.

An electrochemical nanosensor was fabricated on a single gold nanoelectrode for thrombin sensing with high sensitivity via a signal amplification strategy.

An “off–on” phosphorescent aptasensor was developed to detect thrombin based on PRET and the formation of an antiparallel G-quadruplex.

A robust pyrene-involved MOF is developed as a luminescent platform for sensitive detection of 1-hydroxypyrene, a human intoxication biomarker of PAH carcinogens, by utilizing the efficient host–guest π–π charge transfer interactions.

A PTCA-RGO-MWCNT-Au NP nanocomposite was facilely fabricated for highly sensitive and selective electrochemical detection of dopamine.

The addition of Cu²⁺ to a CD solution quenches the fluorescence emission of CDs while on the addition of TrxR, 2-mercaptopropanoic acid released from the surface of the CDs and emission from CDs was regained.

Non-invasive detection of PSA in human saliva.

A novel multifunctional sensor, RSPT, was identified and developed for multichannel turn-on fluorescent responses to Zn²⁺ and Bi³⁺ in practice.

Hydrogen sulfide (H₂S) and biothiol molecules, such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy), play an important role in biology.

An aptamer based SERS sensor was developed to detect picomolar concentrated ochratoxin solutions using an OPLS model.

A new water soluble and fluorogenic probe (L) that can demonstrate the specific ratiometric detection of a SO₂ derivative (SO₃²⁻) in 100% aqueous medium and live cells has been designed and synthesized.

A functionalized gold nanoparticle-enhanced competitive assay was developed to overcome the sensitivity challenge associated with direct SPR sensing of small-molecule metabolites.

Herein, we report the synthesis and characterization of a conducting polymer film used as a simple and novel multi-signal sensor platform which demonstrates ion selective potentiometric, colorimetric and voltammetric responses in aqueous media.

Due to the high cost and environmental instability of antibodies, there is precedent for developing synthetic molecular recognition agents for use in diagnostic sensors.

Surface plasmon-enhanced fluorescence for the readout of a assay with low affinity split aptamer.

A smart plasmonic SERS platform, comprising a layer of a stimuli-responsive polymer sandwiched between two gold layers, is reported.

A facile means for the detection of iodide ions with ssDNA-CuNPs due to the fluorescence decrease was proposed.

The sensing specificity of a fluorescence resonance energy transfer (FRET)-based MoS₂ nanosheet aptasensor to detect the malarial biomarker Plasmodium lactate dehydrogenase (pLDH) is significantly enhanced through surface passivation in this work.

Functional CuO/Pt nanocomposites were successfully constructed as peroxidase mimics for highly selective colorimetric detection of ascorbic acid.

An ultrasensitive electrochemiluminescence (ECL) immunosensor for carbohydrate antigen 19-9 (CA19-9) detection using multi-walled carbon nanotube–platinum–luminol nanocomposites (MWCNT–Pt–luminol) as nanointerface and signal tags was designed.

We report a stripping voltammetric immunoassay for the electrochemical detection of disease specific exosomes using quantum dots as electrochemical signal amplifiers.

We develop a ratiometric electrochemical biosensor for DNA assay based on DNA four-way junction formation and enzyme-assisted recycling amplification.

A highly sensitive electrochemical sensor based on a carbon paste electrode (CPE) modified with molecularly imprinted polymeric microspheres (MIPMSs) was developed for the determination of bisphenol A (BPA).

A microneedle array based biosensor for minimally invasive electrochemical monitoring of organophosphate (OP) nerve agents under the skin.