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Issue 10, 2017
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Copper-catalyzed C–O bond cleavage and cyclization: synthesis of indazolo[3,2-b]quinazolinones

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Abstract

The first example of a copper-catalyzed halogen-free protocol to construct indazolo[3,2-b]quinazolinones was developed through sequential inert C–O bond cleavage followed by intramolecular C–N bond formation. This protocol represents an efficient synthetic tool for accessing a more diverse range of functionalized indazolo[3,2-b]quinazolinones. The structure of the newly synthesized indazolo[3,2-b]quinazolinones was unambiguously confirmed by X-ray crystal diffraction analysis.

Graphical abstract: Copper-catalyzed C–O bond cleavage and cyclization: synthesis of indazolo[3,2-b]quinazolinones

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Publication details

The article was received on 29 okt. 2016, accepted on 23 des. 2016 and first published on 23 des. 2016


Article type: Paper
DOI: 10.1039/C6OB02352E
Citation: Org. Biomol. Chem., 2017,15, 2168-2173
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    Copper-catalyzed C–O bond cleavage and cyclization: synthesis of indazolo[3,2-b]quinazolinones

    R. Qiao, L. Ye, K. Hu, S. Yu, W. Yang, M. Liu, J. Chen, J. Ding and H. Wu, Org. Biomol. Chem., 2017, 15, 2168
    DOI: 10.1039/C6OB02352E

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