Jump to main content
Jump to site search

Issue 5, 2016
Previous Article Next Article

Molecular design for growth of supramolecular membranes with hierarchical structure

Author affiliations

Abstract

Membranes with hierarchical structure exist in biological systems, and bio-inspired building blocks have been used to grow synthetic analogues in the laboratory through self-assembly. The formation of these synthetic membranes is initiated at the interface of two aqueous solutions, one containing cationic peptide amphiphiles (PA) and the other containing the anionic biopolymer hyaluronic acid (HA). The membrane growth process starts within milliseconds of interface formation and continues over much longer timescales to generate robust membranes with supramolecular PA–HA nanofibers oriented orthogonal to the interface. Computer simulation indicates that formation of these hierarchically structured membranes requires strong interactions between molecular components at early time points in order to generate a diffusion barrier between both solutions. Experimental studies using structurally designed PAs confirm simulation results by showing that only PAs with high ζ potential are able to yield hierarchically structured membranes. Furthermore, the chemical structure of such PAs must incorporate residues that form β-sheets, which facilitates self-assembly of long nanofibers. In contrast, PAs that form low aspect ratio nanostructures interact weakly with HA and yield membranes that exhibit non-fibrous fingering protrusions. Furthermore, experimental results show that increasing HA molecular weight decreases the growth rate of orthogonal nanofibers. This result is supported by simulation results suggesting that the thickness of the interfacial contact layer generated immediately after initiation of self-assembly increases with polymer molecular weight.

Graphical abstract: Molecular design for growth of supramolecular membranes with hierarchical structure

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 sep. 2015, accepted on 30 nóv. 2015 and first published on 09 des. 2015


Article type: Paper
DOI: 10.1039/C5SM02381E
Author version available: Download Author version (PDF)
Citation: Soft Matter, 2016,12, 1401-1410
  •   Request permissions

    Molecular design for growth of supramolecular membranes with hierarchical structure

    R. Helen Zha, Y. S. Velichko, R. Bitton and S. I. Stupp, Soft Matter, 2016, 12, 1401
    DOI: 10.1039/C5SM02381E

Search articles by author

Spotlight

Advertisements