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Issue 7, 2016
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Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites

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Abstract

We have developed a theranostic nanocomposite of metallic nanoparticles that uses two distinct fluorescence mechanisms: Förster Resonance Energy Transfer (FRET) and Metal-Enhanced Fluorescence (MEF) controlled by ligand–receptor interaction. Supramolecular assembly of the fluorophore-labeled glycoligands to cyclodextrin-capped gold nanoparticles produces a nanocomposite with a quenched fluorescence due to FRET from the fluorophore to the proximal particle. Subsequently, interaction with a selective protein receptor leads to an aggregation of the composite, reactivating the fluorescence by MEF from the distal metallic particles to fluorophores encapsulated in the aggregates. The aggregation also causes a red-shift in absorbance of the composite, thereby enhancing the production of reactive oxygen species (ROS) on red-light irradiation. Our nanocomposite has proven suitable for targeted cancer cell imaging as well as multimode therapy using both the photodynamic and drug delivery properties of the composite.

Graphical abstract: Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites

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Publication details

The article was received on 02 apr. 2016, accepted on 03 maí 2016 and first published on 04 maí 2016


Article type: Edge Article
DOI: 10.1039/C6SC01463A
Citation: Chem. Sci., 2016,7, 4004-4008
  • Open access: Creative Commons BY license
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    Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites

    X. Hu, Y. Zang, J. Li, G. Chen, T. D. James, X. He and H. Tian, Chem. Sci., 2016, 7, 4004
    DOI: 10.1039/C6SC01463A

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