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Issue 3, 2016
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A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

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Abstract

The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a fluorogenic green emissive rhodol dye conjugated via a singlet oxygen cleavable aminoacrylate (AA) linker. The probe emits red fluorescence in water, and the red emissive PS can be used for probe self-tracking. Upon image-guided light irradiation, the generated singlet oxygen cleaves the AA linker to yield green fluorescence turn-on of rhodol, which offers real-time and in situ monitoring of singlet oxygen generation during photodynamic ablation of cancer cells, providing a strategy for the early evaluation of the therapeutic effect.

Graphical abstract: A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

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Publication details

The article was received on 22 sep. 2015, accepted on 23 nóv. 2015 and first published on 23 nóv. 2015


Article type: Edge Article
DOI: 10.1039/C5SC03583J
Citation: Chem. Sci., 2016,7, 1862-1866
  • Open access: Creative Commons BY license
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    A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

    Y. Yuan, C. Zhang, S. Xu and B. Liu, Chem. Sci., 2016, 7, 1862
    DOI: 10.1039/C5SC03583J

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