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Issue 2, 2016
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Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles

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Abstract

The rise of hospital-acquired infections, also known as nosocomial infections, is a growing concern in intensive healthcare, causing the death of hundreds of thousands of patients and costing billions of dollars worldwide every year. In addition, a decrease in the effectiveness of antibiotics caused by the emergence of drug resistance in pathogens living in biofilm communities poses a significant threat to our health system. The development of new therapeutic agents is urgently needed to overcome this challenge. We have developed new dual action polymeric nanoparticles capable of storing nitric oxide, which can provoke dispersal of biofilms into an antibiotic susceptible planktonic form, together with the aminoglycoside gentamicin, capable of killing the bacteria. The novelty of this work lies in the attachment of NO-releasing moiety to an existing clinically used drug, gentamicin. The nanoparticles were found to release both agents simultaneously and demonstrated synergistic effects, reducing the viability of Pseudomonas aeruginosa biofilm and planktonic cultures by more than 90% and 95%, respectively, while treatments with antibiotic or nitric oxide alone resulted in less than 20% decrease in biofilm viability.

Graphical abstract: Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles

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Publication details

The article was received on 29 júl. 2015, accepted on 24 okt. 2015 and first published on 10 nóv. 2015


Article type: Edge Article
DOI: 10.1039/C5SC02769A
Citation: Chem. Sci., 2016,7, 1016-1027
  • Open access: Creative Commons BY license
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    Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles

    T. Nguyen, R. Selvanayagam, K. K. K. Ho, R. Chen, S. K. Kutty, S. A. Rice, N. Kumar, N. Barraud, H. T. T. Duong and C. Boyer, Chem. Sci., 2016, 7, 1016
    DOI: 10.1039/C5SC02769A

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