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Issue 23, 2016
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Magnetically-responsive silica–gold nanobowls for targeted delivery and SERS-based sensing

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Abstract

Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.

Graphical abstract: Magnetically-responsive silica–gold nanobowls for targeted delivery and SERS-based sensing

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Publication details

The article was received on 24 mar. 2016, accepted on 30 apr. 2016 and first published on 03 maí 2016


Article type: Paper
DOI: 10.1039/C6NR02445A
Citation: Nanoscale, 2016,8, 11840-11850
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    Magnetically-responsive silica–gold nanobowls for targeted delivery and SERS-based sensing

    A. H. Mo, P. B. Landon, K. S. Gomez, H. Kang, J. Lee, C. Zhang, W. Janetanakit, V. Sant, T. Lu, D. A. Colburn, S. Akkiraju, S. Dossou, Y. Cao, K. Lee, S. Varghese, G. Glinsky and R. Lal, Nanoscale, 2016, 8, 11840
    DOI: 10.1039/C6NR02445A

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