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Issue 18, 2016
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Single-stranded DNA detection by solvent-induced assemblies of a metallo-peptide-based complex

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Abstract

DNA detection is highly important for the sensitive sensing of different pathogenic bacteria and viruses. The major challenge is to create a sensor that can selectively detect very small concentrations of DNA without the need for amplification or complicated equipment. Different technologies such as optical, electrochemical and microgravimetric approaches can detect DNA fragments. Here we show, for the first time, the use of self-assembled nanostructures generated by a metallo-peptide as an optical sensing platform for DNA detection. The system can selectively detect single stranded DNA fragments by fluorescence measurements as it can discriminate even one base mismatch and can perform in the presence of other interfering proteins. This system may be useful in lab-on-a-chip applications.

Graphical abstract: Single-stranded DNA detection by solvent-induced assemblies of a metallo-peptide-based complex

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Publication details

The article was received on 03 nóv. 2015, accepted on 16 nóv. 2015 and first published on 05 jan. 2016


Article type: Paper
DOI: 10.1039/C5NR07714A
Citation: Nanoscale, 2016,8, 9527-9536
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    Single-stranded DNA detection by solvent-induced assemblies of a metallo-peptide-based complex

    P. Das and M. Reches, Nanoscale, 2016, 8, 9527
    DOI: 10.1039/C5NR07714A

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