Jump to main content
Jump to site search

Issue 8, 2016
Previous Article Next Article

Synthesis and characterization of a novel N–F reagent derived from the ethano-Tröger's base: 1JFN coupling constants as a signature for the N–F bond

Author affiliations

Abstract

Methylation of 2,8-dimethyl-6H,12H-5,11-ethanodibenzo[b,f][1,5]-diazocine (ethano-Tröger's base) with methyl iodide followed by ion metathesis and fluorination with N-fluoro-2,3,4,5,6-pentachloropyridinium triflate affords a new electrophilic N–F reagent, that is more reactive than Selectfluor. 2D 19F–15N HMQC experiments provide 1JNF coupling constants which are diagnostic for the N–F functional group.

Graphical abstract: Synthesis and characterization of a novel N–F reagent derived from the ethano-Tröger's base: 1JFN coupling constants as a signature for the N–F bond

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 okt. 2015, accepted on 24 nóv. 2015 and first published on 25 nóv. 2015


Article type: Communication
DOI: 10.1039/C5CC08375C
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 1606-1609
  •   Request permissions

    Synthesis and characterization of a novel N–F reagent derived from the ethano-Tröger's base: 1JFN coupling constants as a signature for the N–F bond

    R. Pereira, J. Wolstenhulme, G. Sandford, T. D. W. Claridge, V. Gouverneur and J. Cvengroš, Chem. Commun., 2016, 52, 1606
    DOI: 10.1039/C5CC08375C

Search articles by author

Spotlight

Advertisements