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Issue 3, 2016
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A tool for the selective sequestration of ATP and PPi to aid in-solution phosphopeptide detection assays

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Abstract

The presence of small phospho-anions, such as PPi and ATP in protein samples often complicates the robust detection of phosphoproteins by metal-based chemosensors and receptors. We herein report the development of a bis(Zn2+-cyclen)-triethylbenzene scaffold which can selectively sequester PPi and ATP without affecting the detection of a di-phosphorylated peptide by a ProxyPhos chemosensor.

Graphical abstract: A tool for the selective sequestration of ATP and PPi to aid in-solution phosphopeptide detection assays

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Publication details

The article was received on 14 júl. 2015, accepted on 02 des. 2015 and first published on 02 des. 2015


Article type: Communication
DOI: 10.1039/C5AN01414J
Author version available: Download Author version (PDF)
Citation: Analyst, 2016,141, 820-822
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    A tool for the selective sequestration of ATP and PPi to aid in-solution phosphopeptide detection assays

    E. Duodu, D. Kraskouskaya, R. F. Gómez-Biagi and P. T. Gunning, Analyst, 2016, 141, 820
    DOI: 10.1039/C5AN01414J

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