Jump to main content
Jump to site search

Issue 3, 2016
Previous Article Next Article

Asymmetric 18F-fluorination for applications in positron emission tomography

Author affiliations

Abstract

Positron emission tomography (PET) is becoming more frequently used by medicinal chemists to facilitate the selection of the most promising lead compounds for further evaluation. For PET, this entails the preparation of 11C- or 18F-labeled drugs or radioligands. With the importance of chirality and fluorine substitution in drug development, chemists can be faced with the challenge of preparing enantiopure molecules featuring the 18F-tag on a stereogenic carbon. Asymmetric 18F-fluorination is an emerging field of research that provides an alternative to resolution or conventional SN2-based radiochemistry. To date, both transition metal complexes and organomediators have been successfully employed for 18F-incorporation at a stereogenic carbon.

Graphical abstract: Asymmetric 18F-fluorination for applications in positron emission tomography

Back to tab navigation

Publication details

The article was received on 06 nóv. 2015, accepted on 12 des. 2015 and first published on 17 des. 2015


Article type: Minireview
DOI: 10.1039/C5SC04229A
Citation: Chem. Sci., 2016,7, 1645-1652
  • Open access: Creative Commons BY license
  •   Request permissions

    Asymmetric 18F-fluorination for applications in positron emission tomography

    F. Buckingham and V. Gouverneur, Chem. Sci., 2016, 7, 1645
    DOI: 10.1039/C5SC04229A

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements