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Issue 10, 2015
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A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy

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Abstract

A supramolecular nanovehicle (denoted as SNV) was fabricated by encapsulating zinc phthalocyanine (ZnPc) and doxorubicin (DOX) into a copolymer (PVP-b-PAA-g-FA), so as to achieve systematic and synergistic chemotherapy-photodynamic therapy (PDT), targeted tumor imaging and therapy. The sophisticated copolymer designed in this work can load the PDT photosensitizer (ZnPc) and chemotherapy drug (DOX) simultaneously, which exhibits an excellent performance in chemotherapy-PDT targeted cancer and tumor therapy for both in vitro studies performed with HepG2 cells and in vivo tests with mice. This work provides a new drug formulation with a chemotherapy-PDT synergistic effect by virtue of the supramolecular material design, which possesses the advantages of an ultra-low drug dosage and highly-efficient in vivo targeted tumor imaging/therapy.

Graphical abstract: A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy

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Publication details

The article was received on 19 mar. 2015, accepted on 22 jún. 2015 and first published on 22 jún. 2015


Article type: Edge Article
DOI: 10.1039/C5SC00994D
Citation: Chem. Sci., 2015,6, 5511-5518
  • Open access: Creative Commons BY-NC license
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    A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy

    R. Liang, S. You, L. Ma, C. Li, R. Tian, M. Wei, D. Yan, M. Yin, W. Yang, D. G. Evans and X. Duan, Chem. Sci., 2015, 6, 5511
    DOI: 10.1039/C5SC00994D

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