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Issue 58, 2015
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Multi-functional fluorescent carbon dots with antibacterial and gene delivery properties

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Abstract

Glucose is abundant in nature and can be found in various sources. In this study, we developed multifunctional carbon dots (CDs) with glucose and poly(ethyleneimine) (PEI), which were further quaternized using a facile approach. The CDs are designed to possess both anti-bacteria and gene delivery capabilities. The inherent property was characterized with TEM, NMR, FTIR and fluorescent spectroscopy. Antibacterial activity was evaluated with Broth minimum inhibitory concentration (MIC) assay on both Gram-positive and Gram-negative bacteria. The CDs showed excellent inhibitation to both bacteria. The expression of CDs condensed plasmid DNA in HEK 293T cells was investigated with luciferase expression assay. Gene transfection capability of the quaternized CDs was found to be up to 104 times efficient than naked DNA delivery.

Graphical abstract: Multi-functional fluorescent carbon dots with antibacterial and gene delivery properties

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Publication details

The article was received on 30 apr. 2015, accepted on 13 maí 2015 and first published on 13 maí 2015


Article type: Communication
DOI: 10.1039/C5RA07968C
Citation: RSC Adv., 2015,5, 46817-46822
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    Multi-functional fluorescent carbon dots with antibacterial and gene delivery properties

    Q. Dou, X. Fang, S. Jiang, P. L. Chee, T. Lee and X. J. Loh, RSC Adv., 2015, 5, 46817
    DOI: 10.1039/C5RA07968C

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