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Issue 5, 2015
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Selective NaOH-catalysed hydration of aromatic nitriles to amides

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Abstract

The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.

Graphical abstract: Selective NaOH-catalysed hydration of aromatic nitriles to amides

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Publication details

The article was received on 03 mar. 2015, accepted on 18 mar. 2015 and first published on 24 mar. 2015


Article type: Paper
DOI: 10.1039/C5CY00313J
Citation: Catal. Sci. Technol., 2015,5, 2865-2868
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    Selective NaOH-catalysed hydration of aromatic nitriles to amides

    T. E. Schmid, A. Gómez-Herrera, O. Songis, D. Sneddon, A. Révolte, F. Nahra and C. S. J. Cazin, Catal. Sci. Technol., 2015, 5, 2865
    DOI: 10.1039/C5CY00313J

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