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Issue 91, 2015
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Synthesis and base pairing studies of geranylated 2-thiothymidine, a natural variant of thymidine

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Abstract

The synthesis and base pairing of DNA duplexes containing the geranylated 2-thiothymidine have been investigated. This naturally existing hydrophobic modification could grant better base pairing stability to the T–G pair over normal T–A and other mismatched pairs in the duplex context. This study provides a potential explanation for the different codon recognition preferences of the geranylated tRNAs.

Graphical abstract: Synthesis and base pairing studies of geranylated 2-thiothymidine, a natural variant of thymidine

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The article was received on 06 sep. 2015, accepted on 15 sep. 2015 and first published on 15 sep. 2015


Article type: Communication
DOI: 10.1039/C5CC07479G
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 16369-16372
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    Synthesis and base pairing studies of geranylated 2-thiothymidine, a natural variant of thymidine

    R. Wang, S. V. Ranganathan, M. Basanta-Sanchez, F. Shen, A. Chen and J. Sheng, Chem. Commun., 2015, 51, 16369
    DOI: 10.1039/C5CC07479G

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