Issue 27, 2014
From the journal:

RSC Advances

Pd-catalyzed dehydrogenative cross-coupling of pyridine-N-oxides with uracils†

Ebrahim Kianmehr,*a   Masoud Rezaeefard,a   Mehran Rezazadeh Khalkhalia  and  Khalid Mohammed Khanb  

* Corresponding authors

a School of Chemistry, College of Science, University of Tehran, Tehran, Iran
E-mail: kianmehr@khayam.ut.ac.ir
Fax: +98-21-66495291
Tel: +98-21-61113301

b H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Abstract

A highly efficient protocol for the regioselective dehydrogenative cross-coupling of pyridine-N-oxides with N,N-dialkyl uracils via 2-fold C–H activation has been developed. The resultant uracil substituted pyridine-N-oxide structural motifs is readily deoxygenated, making the present procedure a highly attractive route for the synthesis of 5-pyridine substituted uracils.

Graphical abstract: Pd-catalyzed dehydrogenative cross-coupling of pyridine-N-oxides with uracils

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Article information

DOI
https://doi.org/10.1039/C4RA01034E
Article type
Communication
Submitted
05 feb. 2014
Accepted
28 feb. 2014
First published
13 mar. 2014

RSC Adv., 2014,4, 13764-13767

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Pd-catalyzed dehydrogenative cross-coupling of pyridine-N-oxides with uracils

E. Kianmehr, M. Rezaeefard, M. Rezazadeh Khalkhali and K. M. Khan, RSC Adv., 2014, 4, 13764 DOI: 10.1039/C4RA01034E

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