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Issue 8, 2014
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A smartphone platform for the quantification of vitamin D levels

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Abstract

Vitamin D deficiency has been linked to a number of diseases and adverse outcomes including: osteoporosis, infections, diabetes, cardiovascular diseases, and even cancer. At present the vast majority of vitamin D testing is performed in large-scale laboratories at the request of a physician as part of an annual panel of blood tests. Here we present a system for rapid quantification of vitamin D levels on a smartphone. The system consists of a smartphone accessory, an app, and a test strip that allows the colorimetric detection of 25-hydroxyvitamin D using a novel gold nanoparticle-based immunoassay. We show that the system can be used to accurately measure physiological levels of 25-hydroxyvitamin D with accuracy better than 15 nM and a precision of 10 nM. We compare our system with well-established ELISA test kits for serum samples of unknown concentration and demonstrate equivalency of the results. We envision this as the first step towards the development of the NutriPhone, a comprehensive system for the analysis of multiple vitamins and micronutrients on a smartphone.

Graphical abstract: A smartphone platform for the quantification of vitamin D levels

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Publication details

The article was received on 11 des. 2013, accepted on 07 feb. 2014 and first published on 07 feb. 2014


Article type: Paper
DOI: 10.1039/C3LC51375K
Author version available: Download Author version (PDF)
Citation: Lab Chip, 2014,14, 1437-1442
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    A smartphone platform for the quantification of vitamin D levels

    S. Lee, V. Oncescu, M. Mancuso, S. Mehta and D. Erickson, Lab Chip, 2014, 14, 1437
    DOI: 10.1039/C3LC51375K

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