Najrul Hussainac,
Pranjal Gogoi*bc,
Puja Khared and
Manash R. Das*ac
aMaterials Science Division, CSIR-North East Institute of Science and Technology, Jorhat-785006, Assam, India. E-mail: mnshrdas@yahoo.com; gogoipranj@yahoo.co.uk
bMedicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat-785006, Assam, India
cAcademy of Scientific and Innovative Research, CSIR, India
dAgronomy & Soil Science Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Near Kukrail Picnic Spot, Lucknow-226015, Lucknow, India
First published on 13th November 2015
In this study, we have developed a cost effective and one-pot strategy for the synthesis of a heterogeneous catalyst consisting of a Ni nanoparticle–reduced graphene oxide composite for Sonogashira cross-coupling reactions. Several characterization tools were employed to characterize the Ni nanoparticle–reduced graphene oxide composite, which indicated that magnetic Ni nanoparticles of a size range of 1–4 nm were uniformly anchored on the reduced graphene oxide nanosheets without using any surfactant or stabilizing agent. Different types of aryl halides and phenylacetylenes were coupled under the optimized reaction conditions with excellent yields to give biphenylacetylenes. The ferromagnetic behaviour of the Ni nanoparticle–graphene composite resulted in it being easily separable from the reaction mixture and the composite was reusable, up to six times, without losing its catalytic activity. The fresh as well as the reused catalyst for the Sonogashira cross-coupling reaction was well characterized using analytical techniques which showed that the Ni nanoparticles were well dispersed on the reduced graphene oxide nanosheets without agglomeration, and the size and morphology of the catalyst remained unchanged after use in the catalytic reaction.
In view of these advantageous properties of metal–graphene composite materials for heterogenous catalysis, some metal nanoparticles have been designed on the surface of graphene sheets for catalytic applications such as CO oxidation, oxidation of alcohols, degradation of organic pollutants, hydrogenation of CC and CO bonds, selective reduction of nitroarenes, Fischer–Tropsch synthesis and coupling reactions.1,13 However, most of these reports deals with the problem of separation of the catalyst from the reaction mixture, which lead to trace amounts of metal contaminants in the product. This problem can be easily overcome by designing a magnetically separable heterogeneous catalyst. In this regard, the development of environmentally friendly, cost effective, practical, and efficient catalytic processes with catalyst reusability has attracted worldwide attention in the field of catalysis. Therefore, in this report, we have decorated magnetic Ni nanoparticles onto the surface of reduced graphene oxide sheets (rGO), which showed excellent ferromagnetic properties and thereby results in effective magnetic separation of the catalyst after completion of the reaction. Magnetic separation of the catalyst is more effective than filtration or centrifugation as it prevents loss of the catalyst. Magnetic separation of the catalyst from the reaction system is simple, cost-effective and favorable for industrial applications. The magnetic Ni nanoparticle–rGO composite material is also a low cost heterogeneous catalyst compared to having a noble metal (Au, Ag, Pt and Pd) anchored on the graphene sheets.
The Sonogashira cross-coupling reaction is one of the most important carbon–carbon bond formation reactions in organic synthesis. This coupling reaction has been extensively used for the synthesis of various pharmaceuticals, bioactive compounds, natural products, molecular organic materials and engineered materials.14–16 This reaction has been well-developed and admirable results can be obtained with Pd-complexes with phosphine ligands.17–20 However, the most commonly used phosphine ligands are sensitive to air and moisture, which means an inert atmosphere is required as a prerequisite during handling, and even a trace amount of such a ligand may act as an inhibitor in some metal-catalyzed asymmetric reactions.21 Therefore, the development of a ligand- and additive-free Pd catalyst is of immense interest. On the other hand, the use of a stable and reusable heterogeneous catalyst to replace the homogenous catalyst for Sonogashira cross-coupling reactions is of great importance in sustainable chemistry. Various heterogeneous Pd nanoparticles have been developed and efficiently used for the Sonogashira cross-coupling reaction.22–24 Although some of these catalysts are highly efficient, most of them gave a low yield of the coupling product even in the presence of different additives.25–27 To enhance the efficiency of the catalyst, bimetallic nanoparticles comprising Pd metal with other non-noble metals such as copper, nickel, iron and cobalt are used in the Sonogashira cross-coupling reaction. Bimetallic nanoparticles such as Ag–Pd@rGO,28 Pd/Co alloy NPs,29 Pd–Co/G alloy NPs,30 Pd/Cu mixed NPs,31 Pd/Ni core shell NPs,32 hollow Pd–Co nanospheres,33 nano-Pd/PdO/Cu systems,34 Pd/Cu nano-alloys,35 and rGO–Cu48Pd52 alloy nanoparticles36 are notable examples that were recently reported for this reaction.
Nickel is a promising and cheaper alternative to the use of a Pd-based catalyst for the Sonogashira cross-coupling reaction. Among the literature found for Sonogashira cross-coupling reactions of aryl halides with phenylacetylenes catalyzed by nickel, Yin et al. have reported the use of a mesoporous silica supported Ni(II) organometallic complex as a reusable catalyst for the Sonogashira cross-coupling reaction.37 Beletskaya et al. reported a homogenous Ni(II) species as an efficient catalyst for the Sonogashira cross-coupling reaction.38 Farjadian et al. showed that poly(vinylpyridine)-grafted silica containing Ni nanoparticles is an efficient catalyst for the Sonogashira cross-coupling reaction of aryl halides and phenylacetylene.39 Wang et al. reported a Ni(0) powder catalyzed Sonogashira cross-coupling reaction in the presence of cuprous iodide and triphenylphosphine.40 Recently, a Ni–Cu system has been developed by Bakherad and his co-workers for the Sonogashira cross-coupling reaction of terminal acetylenes with aryl iodides in the presence of sodium lauryl sulphate.41 Most of these previous reports require either the use of phosphine ligands and surfactant or an inert atmosphere during the reaction.
As a part of our continuous efforts in the synthesis of metal nanoparticle–graphene composite materials and their application in the catalytic field,42–44 herein we have reported the synthesis of magnetically separable Ni nanoparticles on rGO sheets under ligand-free conditions and their application in Sonogashira cross-coupling reactions in the presence of cuprous iodide. To the best of our knowledge, there is no report on Sonogashira cross-coupling reactions catalyzed by magnetic Ni nanoparticles anchored on rGO. In view of this we have developed a heterogeneous catalyst of a very cheap, magnetically recoverable and reusable Ni nanoparticle–rGO composite for the Sonogashira cross-coupling reaction.
Thermogravimetric analysis (TGA), as shown in Fig. 2, provided information on the reduction of GO to rGO and the formation of Ni nanoparticles on the rGO sheets at the same time. The major weight loss of 37.72% that occurred at a temperature around 200 °C is attributed to decomposition of the labile oxygen-containing functional groups present in GO. The weight loss in this region dramatically decreases to 9.72% after formation of the Ni nanoparticle–rGO composite material because of the reduction of the oxygen containing functional groups present in GO, such as carbonyl, hydroxyl, epoxy and carboxyl groups. The weight loss found above 600 °C for both the Ni nanoparticle–rGO composite material and GO results from pyrolysis of the carbon skeleton of the rGO nanosheets.
The catalytic activity of the catalyst mainly depends on the size and shape of the nanoparticles distributed on the support in a heterogeneous catalysis system. In this regard, we have examined the morphology of the Ni nanoparticles anchored on the rGO sheets (Fig. 3). Graphene sheets of micron size are clearly visible in the TEM images and the Ni nanoparticles are uniformly distributed on those sheets. Ni nanoparticles of a mean diameter of 2.7 nm with a narrow particle size distribution are embedded in the rGO sheets and are spherical in nature. The size of our synthesized Ni nanoparticles is very small in comparison to other previous reports of the synthesis of Ni nanoparticles.45–49 The small size and uniform distribution of the synthesized Ni nanoparticles result from a strong interaction between the surface of the rGO sheets and Ni nanoparticles.50 Lu et al. proposed that the interaction between the graphene and Ni is attributed to partially occupied d-orbitals which are localized in the vicinity of the Fermi level.51 This result clearly fulfils our aim to prepare very small-sized nanoparticles and thereby a large surface to volume ratio in order to get excellent catalytic activity. Xu et al. recently reported Ni nanoparticles of an average size of 9.7 nm decorated on graphene sheets with narrow size distribution.52 Wu et al. also demonstrated the synthesis of a Ni nanoparticle–graphene composite using a solvothermal method via electrostatic induced spread adsorption. Ni nanoparticles of an average size of ∼55 nm were well distributed on the graphene sheets.45 For another synthesis method reported by Tian et al., it was observed that Ni nanoparticles of an average size of 8 nm were homogeneously decorated on rGO sheets in the presence of poly(N-vinyl-2-pyrolidone) (PVP).48 However, Ni nanoparticles of an average size of ∼27 nm were decorated on the rGO sheets without using the stabilizing agent PVP due to agglomeration of the Ni nanoparticles. The surface morphology and elemental composition of the obtained composite material were examined using SEM-EDS (shown in Fig. 4(a)–(c)). The crumpled and rippled structure of GO which results from deformation upon exfoliation is partially destroyed in the composite material due to the reduction of a large amount of oxygen containing functional groups (Fig. 4a and b). Although the rGO sheets were layered in structure, it is irregular and folded where the spherical Ni nanoparticles are uniformly distributed. The EDS analysis (shown in Fig. 4c) clearly confirmed sufficient loading of the Ni nanoparticles onto the surface of the rGO sheets with an insignificant amount of oxygen, which remains due to the presence of unreduced oxygen containing functional groups.
Fig. 3 TEM images of the Ni nanoparticles on rGO nanosheets (a–c). TEM image along with particle size distribution (a), SAED image of Ni nanoparticles (d). |
Fig. 4 SEM images of the Ni nanoparticles on rGO nanosheets (a and b); EDS analysis of the Ni nanoparticle–rGO composite material (c). |
The FTIR spectra of GO and the Ni nanoparticle–rGO composite are shown in Fig. 5. As shown in Fig. 5, prominent peaks at 3131, 1728, 1583, 1436, and 1042 cm−1 occur for GO and are attributed to the stretching vibrations of O–H, CO, CC, C–O–H and C–O–C, respectively. The intensities of these peaks decreased significantly after the formation of the Ni nanoparticles on the rGO sheets due to the reduction of these oxygen containing functional groups present in GO.
To investigate the magnetic properties of our synthesized Ni nanoparticle–rGO composite material, magnetic measurements were performed at room temperature in terms of field dependent magnetization measurements (M–H). The results for the saturation magnetization (Ms), remanent magnetization (Mr) and coercivity (Hc) are listed inside Fig. 6. The hysteresis behaviour and the magnetic parameters clearly reveal a ferromagnetic interaction of the synthesized Ni nanoparticles on rGO nanosheets.53–56 As shown in Fig. 6, the Ni nanoparticle–rGO composite shows a saturation magnetization of 43.54 emu g−1 and the reduction of this saturation magnetization value in comparison to bulk nickel is due to the increase in the surface to volume ratio resulting from a decrease in particle size.54 The remanence magnetization (Mr) of the sample was found to be 6.92 emu g−1 and the coercivity (Hc) 197.54 Oe, which is greater than for bulk nickel. The increase in the coercivity value in comparison to bulk nickel confirms the rule of Hc ∝ 1/D for the multidomain ferromagnetic nanoparticles.55 Thus, the excellent ferromagnetic behaviour of the Ni nanoparticle–rGO composite fulfils our aim to develop a more efficient and easily separable catalyst for catalysis reactions.
Fig. 6 Variation of magnetization (M) with magnetic field (H) at room temperature for the Ni nanoparticles supported on rGO sheets. |
Entry | Solvent | Base | Temperature (°C) | Yieldb (%) |
---|---|---|---|---|
a Reaction conditions: bromobenzene (1 mmol), phenylacetylene (1.2 mmol), CuI (0.08 mmol), catalyst (25 mg, 0.15 mmol Ni), base (3 mmol), solvent (5 mL), 4 h.b Isolated yield. | ||||
1 | H2O | K2CO3 | 110 | 15 |
2 | DMF | K2CO3 | 60 | 40 |
3 | DMF | K2CO3 | 120 | 45 |
4 | Toluene | K2CO3 | 120 | 30 |
5 | NMP | K2CO3 | 60 | 70 |
6 | NMP | K2CO3 | 100 | 85 |
7 | NMP | K2CO3 | 120 | 93 |
8 | DMSO | K2CO3 | 100 | 80 |
9 | DMSO | K2CO3 | 120 | 80 |
10 | NMP | KOH | 120 | 50 |
11 | NMP | Na2CO3 | 120 | 92 |
12 | NMP | K3PO4 | 120 | 90 |
13 | NMP | NaOH | 120 | 58 |
After having optimized the reaction conditions, we explored the versatility and efficiency of our catalyst for the Sonogashira cross-coupling reaction using different aryl halides and phenylacetylenes. The results are shown in Table 2. As shown in Table 2, aryl halides such as those containing bromide and iodide efficiently coupled with phenylacetylenes to give an excellent yield of the desired product in spite of the electron-rich, electron-poor and electron-neutral nature of the halide components. The reaction conditions are notably compatible with the presence of a nitro group on the aryl ring. Having established a range of aryl bromides and aryl iodides for use as the coupling partner, we next examined the scope of the cross-coupling reaction using aryl chlorides (Table 2, entries 14 and 15). Under our optimized conditions, the aryl chlorides coupled with terminal alkynes and gave a good yield of the corresponding products. However, the chloroaryl substrates required a long reaction time and high reaction temperature compared to the iodide and bromide substrates in order to get a comparable yield. Additionally, our catalyst system chemoselectively reacted with the bromide, when both chloro- and bromo-groups were present on the same substrate (Table 2, entry 10). Our catalyst system was also applied to a heteroaryl halide, 2-bromopyridine, and the coupling product 3i was obtained in 86% yield (Table 2, entry 16). To further explore the scope of our Ni nanoparticle–rGO catalyst in the Sonogashira cross-coupling reaction, we choose a heteroaryl substrate having both bromo- and iodo-substituents. In this regard, 2-bromo-5-iodopyridine was treated with two equivalents of phenylacetylene under our catalytic conditions. The product 3j was obtained with an excellent yield (Scheme 1).
Entry | Aryl halide (1a–m) | Alkyne (2a or 2b) | Product (3a–i) | Yieldb (%) |
---|---|---|---|---|
a Reaction conditions: aryl halide (1 mmol), phenylacetylene (1.2 mmol), CuI (0.08 mmol), catalyst (25 mg, 0.15 mmol Ni), K2CO3 (3 mmol), NMP (5 mL), 120 °C, 4 h. NP: nanoparticle.b Isolated yield.c The reaction was performed at 140 °C for 16 h. | ||||
1 | 95 | |||
2 | 94 | |||
3 | 95 | |||
4 | 95 | |||
5 | 93 | |||
6 | 91 | |||
7 | 93 | |||
8 | 93 | |||
9 | 88 | |||
10 | 91 | |||
11 | 93 | |||
12 | 93 | |||
13 | 93 | |||
14 | 72c | |||
15 | 70c | |||
16 | 86 |
Scheme 1 Ni nanoparticle–rGO catalysed Sonogashira cross-coupling reaction of 2-bromo-5-iodopyridine with phenylacetylene. |
Furthermore, we have compared our Ni nanoparticle–rGO catalyst with other previously reported heterogeneous as well as homogenous catalysts containing Ni to highlight the advantages of our catalyst in the Sonogashira cross-coupling reaction (Table 3). From these comparison results, we found that our synthesized catalyst is more advantageous with respect to yield and reaction conditions. Moreover, for most of the previously reported cases, the scope of the catalyst in the Sonogashira cross-coupling reaction is limited to only aryl iodides with phenylacetylenes.
Catalyst | Conditions | Yield (%) | Ref. |
---|---|---|---|
Ni nanoparticle–rGO | K2CO3, NMP, CuI, 120 °C, 4 h | 70–95 | This work |
Si–P4VPy–Ni0 | K2CO3, NMP, CuI, 120 °C, 1.5–10 h | 40–90 | 39 |
Pd70Ni30/MWCNTs | NaOH, pyrrolidine, 120 °C, 1 h | 60–74 | 57 |
Ni(PPh3)2Cl2 | K2CO3, [Cu(CH3CN)4]BF4, reflux | 57 | 58 |
NiCl2·6H2O–n-Bu4NBr | NaOH, ethylene glycol, 120 °C, 1–12 h | 46–91 | 59 |
Ni(PPh3)2Cl2 | K2CO3, CuI, dioxane:H2O, reflux, 4 h | 93–100 | 38 |
Ni(0)–CuI–PPh3 | KOH, isopropanol, 80–120 °C, 5 h | 56–98 | 40 |
Ni(PPh3)2Cl2/CuI | Cs2CO3, H2O, surfactant, 60 °C, 2–6 h | 70–92 | 41 |
Ni-PPh2–PMOs(Ph) | K2CO3, CuI, dioxane/H2O, N2 protection | 63–75 | 37 |
At present, the exact mechanism of the reaction is not clear. However, we propose here a plausible mechanism for the Ni nanoparticle–rGO catalyzed Sonogashira cross-coupling reaction, as shown in Scheme 2. We believe that the Ni nanoparticle–rGO undergoes oxidative addition with the aryl halide to form a Ni(II) reactive species, which readily transmetalates with Cu-phenylacetylene to form intermediate A. Finally, the desired coupling product is formed from the resulting intermediate A via reductive elimination.37,58,60
Scheme 2 Proposed mechanism for the Ni nanoparticle–rGO catalyzed Sonogashira cross-coupling reaction. |
Fig. 8 Characterization of the Ni nanoparticle–rGO catalyst after performing the reaction (a) XRD pattern, (b–d) TEM images. |
Since leaching of the nanoparticles from the support is a common problem in catalysis, we have examined the leaching of the Ni nanoparticles from the rGO support by performing a hot filtration test. For this test we considered the Sonogashira-cross coupling reaction of bromobenzene 1e with phenylacetylene 2a. After continuing the reaction for 1.5 h, the catalyst was separated and the conversion to 1,2-diphenylethyne 3a was determined using GC and was found to be 45%. After that, the filtrate part was further heated for another 5 h to check the progress of the reaction. From the results obtained by GC, it was found that no further conversion was observed after separation of the catalyst. This clearly proves that no Ni nanoparticles were leached from the catalyst when performing the reaction.
Footnote |
† Electronic supplementary information (ESI) available. See DOI: 10.1039/c5ra22601e |
This journal is © The Royal Society of Chemistry 2015 |