Issue 28, 2015

Formation of glutathionyl dinitrosyl iron complexes protects against iron genotoxicity

Abstract

Dinitrosyl iron(I) complexes (DNICs), intracellular NO donors, are important factors in nitric oxide-dependent regulation of cellular metabolism and signal transduction. It has been shown that NO diminishes the toxicity of iron ions and vice versa. To gain insight into the possible role of DNIC in this phenomenon, we examined the effect of GS-DNIC formation on the ability of iron ions to mediate DNA damage, by treatment of the pUC19 plasmid with physiologically relevant concentrations of GS-DNIC. It was shown that GS-DNIC formation protects against the genotoxic effect of iron ions alone and iron ions in the presence of a naturally abundant antioxidant, GSH. This sheds new light on the iron-related protective effect of NO under the circumstances of oxidative stress.

Graphical abstract: Formation of glutathionyl dinitrosyl iron complexes protects against iron genotoxicity

Supplementary files

Article information

Article type
Paper
Submitted
09 mar. 2015
Accepted
25 maí 2015
First published
26 maí 2015

Dalton Trans., 2015,44, 12640-12652

Author version available

Formation of glutathionyl dinitrosyl iron complexes protects against iron genotoxicity

H. Lewandowska, J. Sadło, S. Męczyńska, T. M. Stępkowski, G. Wójciuk and M. Kruszewski, Dalton Trans., 2015, 44, 12640 DOI: 10.1039/C5DT00927H

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