Issue 4, 2012
From the journal:

Chemical Communications

Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy†

Chian-Hui Lai,a   Yu-Chuan Lin,b   Fong-In Chou,b   Chien-Fu Liang,a   En-Wei Lin,a   Yung-Jen Chuangc  and  Chun-Cheng Lin*a  

* Corresponding authors

a Department of Chemistry, National Tsing Hua University, 101, Sec. 2, Kuang Fu Rd., Hs, Taiwan
E-mail: cclin66@mx.nthu.edu.tw

b Nuclear Science and Technology Development Center, and National Tsing Hua University, 101, Sec. 2, Kuang Fu Rd., Hs, Taiwan

c Department of Medical Science and Institute of Bioinformatics and Structural Biology, National Tsing Hua University, 101, Sec. 2, Kuang Fu Rd., Hs, Taiwan
Fax: +886 3-571-1082

Abstract

A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at killing the HepG2 cells over BSH.

Graphical abstract: Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

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Article information

DOI
https://doi.org/10.1039/C1CC14447B
Article type
Communication
Submitted
21 júl. 2011
Accepted
07 nóv. 2011
First published
23 nóv. 2011

Chem. Commun., 2012,48, 612-614

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Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

C. Lai, Y. Lin, F. Chou, C. Liang, E. Lin, Y. Chuang and C. Lin, Chem. Commun., 2012, 48, 612 DOI: 10.1039/C1CC14447B

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