Issue 8, 2010
From the journal:

Chemical Communications

Platinum(ii) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity†

Zuqin Xue,a   Miaoxin Lin,a   Jianhui Zhu,a   Junfeng Zhang,b   Yizhi Lia  and  Zijian Guo*a  

* Corresponding authors

a State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
E-mail: zguo@nju.edu.cn
Fax: + 86 25 8331 4502
Tel: + 86 25 8359 4549

b State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China

Abstract

Platinum(II) complexes bearing geminal bisphosphonate moieties have excellent solubility in both organic and aqueous solutions and show considerable cytotoxicity against human osteosarcoma (MG-63) and ovarian cancer (COC1) cell lines with different apoptotic pathways from that of cisplatin.

Graphical abstract: Platinum(ii) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity

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Article information

DOI
https://doi.org/10.1039/B922222G
Article type
Communication
Submitted
23 okt. 2009
Accepted
21 des. 2009
First published
16 jan. 2010

Chem. Commun., 2010,46, 1212-1214

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Platinum(II) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity

Z. Xue, M. Lin, J. Zhu, J. Zhang, Y. Li and Z. Guo, Chem. Commun., 2010, 46, 1212 DOI: 10.1039/B922222G

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