Regioselective palladium-catalysed amination of 4-chloroacetoxyalk-2-enoic esters: synthesis of pyrrol-2(5H)-ones (4-but-2-enelactams)
Abstract
Palladium(0)-catalysed reactions of 4-chloroacetoxyalk-2-enoic esters with amines selectively give 4-aminoalk-2-enoic esters, which are readily converted into pyrrol-2(5H)-ones (4-but-2-enelactams).