RSC Advances
Natural products articles published in the last
6 months
Synthetic pathways to create asymmetric center at C1 position of 1-substituted-tetrahydro-β-carbolines – a review
Chiral 1-substituted-THβC can be synthesized from L-tryptophan or tryptamine by Pictet–Spengler reaction and chiral auxiliary; also from substituted-DHβC by ATH reaction with chiral catalysts, asymmetric addition reaction, and enzymatic catalysis.
RSC Adv., 2024,14, 29827-29847
https://doi.org/10.1039/D4RA05961A
New phenanthrenequinones from Cymbidium ensifolium roots and their anti-inflammatory activity on lipopolysaccharide-activated BV2 microglial cells
The roots of Cymbidium ensifolium yielded a total of 17 compounds, comprising two new compounds (1–2), one new natural product (3), and 14 known compounds (4–17).
RSC Adv., 2024,14, 28390-28400
https://doi.org/10.1039/D4RA04761C
Trapping of thermally generated ortho- and para-quinone methides by imidazoles and pyrazoles: a simple route to green synthesis of benzopyrone-azole hybrids and their evaluation as α-glucosidase inhibitors
We demonstrate a protocol for the synthesis of benzopyrone-azole hybrids in the reaction of pyrazoles and (benz)imidazole with phenolic Mannich bases. The target compounds were studied as inhibitors of α-glucosidase.
RSC Adv., 2024,14, 27809-27815
https://doi.org/10.1039/D4RA05230G
FDA-approved drugs containing dimethylamine pharmacophore: a review of the last 50 years
Dimethylamine (DMA) derivatives represent a promising class of compounds with significant potential in the field of medicinal chemistry.
RSC Adv., 2024,14, 27657-27696
https://doi.org/10.1039/D4RA04730C
Biopolymeric nanocarriers in cancer therapy: unleashing the potency of bioactive anticancer compounds for enhancing drug delivery
Effective cancer treatment is becoming a global concern, and recent developments in nanomedicine are essential for its treatment.
RSC Adv., 2024,14, 25149-25173
https://doi.org/10.1039/D4RA03911D
Chemical composition and toxicity studies on Lantana camara L. flower essential oil and its in silico binding and pharmacokinetics to superoxide dismutase 1 for amyotrophic lateral sclerosis (ALS) therapy
Using the gas chromatography mass spectrometry method, the chemical components of essential oil from flowers of Lantana camara growing in Egypt are analyzed.
RSC Adv., 2024,14, 24250-24264
https://doi.org/10.1039/D4RA04281F
The role of current synthetic and possible plant and marine phytochemical compounds in the treatment of acne
Acne is a long-standing skin condition characterized by plugged hair follicles due to the accumulation of dead skin cells, sebum, and Propionibacterium acnes (P. acnes) bacteria, causing inflammation, and the formation of pimples or lesions.
RSC Adv., 2024,14, 24287-24321
https://doi.org/10.1039/D4RA03865G
Baeyer–Villiger oxidation: a promising tool for the synthesis of natural products: a review
Baeyer–Villiger oxidation is a renowned reaction that provides an efficient route for the synthesis of biologically active natural products such as alkaloids, terpenoids, polyketides and fatty acid-based naturally occurring organic compounds.
RSC Adv., 2024,14, 23423-23458
https://doi.org/10.1039/D4RA03914A
Isolation and purification of carbohydrate components in functional food: a review
The workflow for carbohydrate extraction, separation and detection steps.
RSC Adv., 2024,14, 23204-23214
https://doi.org/10.1039/D4RA02748E
Overview of the chemistry and biological activities of natural atisine-type diterpenoid alkaloids
Atisine-type C20-diterpenoid alkaloids are a very important class of diterpenoid alkaloids, which possess high chemical and biological diversity.
RSC Adv., 2024,14, 22882-22893
https://doi.org/10.1039/D4RA03305A
Anticoagulation activity of sulfated carboxymethyl cellulose/Azadirachta indica leaf powder-based bio-composite
The eco-friendly and non-toxic behavior of polymeric bio-composites based on S-CMC, synthesized utilizing natural herbs (Azadirachta indica leaf powder), has shown an interesting anticoagulant activity against diverse physical and chemical actions.
RSC Adv., 2024,14, 22017-22027
https://doi.org/10.1039/D4RA02893G
Drug repositioning identifies salvinorin A and deacetylgedunin (DCG) enriched plant extracts as novel inhibitors of Mpro, RBD–ACE2 and TMPRRS2 proteins
The coronavirus disease 2019 (COVID-19) has spread worldwide with severe health, social, and economic repercussions.
RSC Adv., 2024,14, 21203-21212
https://doi.org/10.1039/D4RA02593H
Advances in gold catalyzed synthesis of quinoid heteroaryls
Synthesis of quinoid heteroaryls via gold-catalyzed cascade protocols: recent advances and methodologies.
RSC Adv., 2024,14, 21047-21064
https://doi.org/10.1039/D4RA03368J
Advances in organocatalyzed synthesis of organic compounds
Recent advancements in utilizing organocatalysts emphasize their simplicity, effectiveness, reproducibility, and high selectivity, resulting in excellent yields of heterocyclic organic compounds.
RSC Adv., 2024,14, 20365-20389
https://doi.org/10.1039/D4RA03046J
Medicinal chemistry perspective on the structure–activity relationship of stilbene derivatives
Stilbenes are polyphenolic secondary metabolites produced in a variety of plant species and show divers biological activities.
RSC Adv., 2024,14, 19823-19879
https://doi.org/10.1039/D4RA02867H
Unveiling the multifaceted antiproliferative efficacy of Cichorium endivia root extract by dual modulation of apoptotic and inflammatory genes, inducing cell cycle arrest, and targeting COX-2
Delving into the therapeutical potential of Cichorium endivia root extract as a natural-based antitumor supplement.
RSC Adv., 2024,14, 19400-19427
https://doi.org/10.1039/D4RA02131B
Ursolic acid inhibits NF-κB signaling and attenuates MMP-9/TIMP-1 in progressive osteoarthritis: a network pharmacology-based analysis
Osteoarthritis (OA) is a degenerative joint disease, characterized by infiltration of monocytes into the synovial joint which promotes inflammation, stiffness, joint swelling, cartilage degradation and further bone destruction.
RSC Adv., 2024,14, 18296-18310
https://doi.org/10.1039/D4RA02780A
Harnessing the 1,3-azadiene-anhydride reaction for the regioselective and stereocontrolled synthesis of lactam-fused bromotetrahydropyrans by bromoetherification of lactam-tethered trisubstituted tertiary alkenols
The bromoetherification of readily affordable lactam-tethered trisubstituted tertiary alkenols has facilitated the site-selective, efficient, and stereocontrolled synthesis of halogenated fused lactam-tetrahydropyrans.
RSC Adv., 2024,14, 18501-18507
https://doi.org/10.1039/D4RA02523G
Sustainable methods for the carboxymethylation and methylation of ursolic acid with dimethyl carbonate under mild and acidic conditions
Carboxymethylation and methylation of ursolic and corosolic acid have been achieved with dimethyl carbonate under sustainable, mild and acidic conditions. The resulting derivatives show potential as novel pharmaceutical intermediates.
RSC Adv., 2024,14, 16921-16934
https://doi.org/10.1039/D4RA02122C
Metabolomic profiling of Medicago sativa-derived fungal endophytes and evaluation of their biological activities
This study aimed to discover the potential of Medicago sativa-derived fungal endophytes as a prospective source of bioactive metabolites.
RSC Adv., 2024,14, 14296-14302
https://doi.org/10.1039/D4RA00790E
Antiviral activity of sulphated specialized metabolites from sea urchin Clypeaster humilis: in vitro and in silico studies
Chemical analyses of the sea urchin Clypeaster humilis yielded twelve compounds including; a new sulfonic acid derivative (7R) tridec-1-en-7-yl hydrogen sulphate (1), pyridine-3-yl methane sulfonate (2), boldine (12), and nine known compounds (3–11).
RSC Adv., 2024,14, 14185-14193
https://doi.org/10.1039/D4RA01966K
Synthesis, characterization, and inhibition effects of a novel eugenol derivative bearing pyrrole functionalities on the corrosion of mild steel in a HCl acid solution
In this work, eugenol was synthetically modified to generate a novel heterocyclic compound. Its structure was characterized by NMR, IR, and X-ray diffraction. The findings of the electrochemical study corroborated these results.
RSC Adv., 2024,14, 14152-14160
https://doi.org/10.1039/D4RA01337A
Exploring the synthetic potential of epoxide ring opening reactions toward the synthesis of alkaloids and terpenoids: a review
Epoxides are oxygen containing three-membered heterocycles which can undergo ring opening reactions. These reactions have been significantly employed in the synthesis of alkaloids and terpenoids-based natural products.
RSC Adv., 2024,14, 13100-13128
https://doi.org/10.1039/D4RA01834F
In vitro and in silico docking and molecular dynamic of antimicrobial activities, alpha-glucosidase, and anti-inflammatory activity of compounds from the aerial parts of Mussaenda saigonensis
Twelve compounds were isolated from Mussaenda saigonensis aerial parts through phytochemical analysis and the genus Mussaenda is the first place where the compounds 4–6 and 11–12 have been found.
RSC Adv., 2024,14, 12081-12095
https://doi.org/10.1039/D4RA01865F
Recent advances in the transformation reactions of the Betti base derivatives
This review article highlights the use of Betti base derivatives in transformation reactions for synthesizing organic compounds, particularly heterocyclic molecules, and investigation into their pharmacological properties.
RSC Adv., 2024,14, 11811-11848
https://doi.org/10.1039/D4RA01256A
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