RSC Advances  

PRP was adsorbed onto MOF and then added to GelMA to promote the effects on cross-linking degree, mechanical and biological properties of GelMA.

The Eu³⁺ doped LuPO₄ nanoparticles were incubated in human lung cancer cells (A549) and the emission was measured via fluorescence microscope.

5f and 5g exhibit significantly enhanced anti-neuroinflammatory effects compared to SS-31 and mitigate rotenone-induced reductions in neuronal ATP levels, as well as the associated increase in mitochondrial reactive oxygen species.

The treatment of diabetic wounds remains a formidable clinical challenge worldwide.

Guided bone regeneration (GBR) uses bone grafts and barrier membranes to block soft tissue invasion to eventually create a new bone.

Simvastatin-loaded DPPC/DPPG proliposomes synthesized by spray drying show aerosol dispersion as dry powder inhalers and in vitro sustained delivery.

The study indicated the absence of saponins, the presence of phytosterols and trigonellin (a pyridine alkaloid), and a low safety risk related to saponin and alkaloid content in the Sacha Inchi seeds.

Herein we demonstrate organocatalyst-mediated protein aldol ligation (OPAL) modification of the bacteriocidin colicin Ia to afford mannose-presenting neoglycoproteins with potential utility for non-genetic glyco-engineering of E. coli cell surfaces.

A series of new benzimidazole–dioxo(benzo)isoindoline conjugates were designed and synthesized as dual VEGFR-2 and FGFR-1 inhibitors. Compound 8m demonstrated potent % inhibition of 80.69% and 76.83% on VEGFR-2 and FGFR-1 at 10 μM, respectively.

Non-immunogenic RNA nanostructures are functionalized for/with RNAi, mRNA, ribozymes, CRISPR, and small molecule drugs. Immunogenic RNA nanostructures are designed as immunostimulants and cancer vaccine platforms. Created in Biorender.com.

A comparative study of normal human fibroblasts and Salla disease patients' fibroblasts reveals changes in the soft X-ray spectroscopic signatures of disease cells. Synchrotron radiation imaging was performed for thin sections and grid-grown cells.

The toxicity of 6 small dendrimers has been investigated in three different human cancer cell lines (HeLa, MCF-7, THP-1) and the endothelial skin cell line HMEC-1 in order to evaluate their potential as vehicles for drug delivery.

Microcalcifications within minimally processed tissue sections from breast cancer patients were analyzed. Most of these microcalcifications were calcite and dolomite crystals, with dolomite being observed in tumorous tissue for the first time.

Twenty-six quinoxalin derivatives were synthesized to assess their biological activities against human non-small-cell lung cancer cells (A549 cells). Among them, compound 4m exhibited the most potent inhibitory activity against A549 cells.

Human glucose transporters (GLUTs) facilitate the uptake of hexoses into cells. In cancer, the increased proliferation necessitates higher expression of GLUTs. This study demonstrates the inhibitory function of ganoderic acid A (GAA) on GLUT1/3.

Recently, molecular hybrids of two or more active pharmacophores have shown promise for designing and synthesizing anticancer drugs.

The interaction between heat shock protein 90 (Hsp90) and Hsp90 co-chaperone cell-division cycle 37 (Cdc37) is crucial for the folding and maturation of several oncogenic proteins, particularly protein kinases.

The bottom-up synthesis of gold nanoparticles (AuNPs) using Ocimum sanctum essential oil extracts exhibited excellent antimicrobial and therapeutic potential against MCF 7 breast carcinoma through flow cytometry analysis and DNA damage studies.

New phthalazine derivatives as vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors were synthesized joined to different spacers including pyrazole, α,β-unsaturated ketonic fragment, pyrimidinone and/or pyrimidinthione.

This study describe one-pot three-component synthesis of bioactive tetrahydopyrimidinecarboxamide employing La(OTf)₃ as a catalyst. Compound, 4f had the most potent anti-cancer activity and impeded cell cycle progression effectively.

Four pyrazol derivatives (4, 5, 7, and 25) showed potent anti-PACA-2 cell line with IC₅₀ (13.0, 31.5 and 24.9, 5.5 μg mL⁻¹) respectively, while compounds 23 and 25 showed potent anti-PC3 cell line with IC₅₀ (26.1 and 11.8 μg mL⁻¹).

Ascorbyl glucoside utilization in the preparation of innovative glucospanlastics loaded itraconazole for topical delivery.

Novel quinazolin-4(3H)-ones 4–27 were synthesized. Compounds 4, 11, and 20 showed potential anti-tumour activities. 4, 11, and 20 blocked EGFR/VEGFR-2 and triggered apoptosis. Compound 4 showed the most potent activity against EGFR/VEGFR-2.

This review highlights recent advances in tendon–bone interface (TBI) tissue regeneration, focusing on the application of electrospinning technology.