RSC Advances  

The UV-crosslinkable benzophenone (BP) “bio-glue” efficiently crosslinks with various surfaces and biomolecules. The beauty of this bio-glue lies in its simplicity and broad applicability, requiring no sophisticated equipment or reaction conditions.

Disulfiram (DSF) can target and kill cancer cells by disrupting cellular degradation of extruded proteins and has therefore received particular attention for its tumor chemotherapeutic potential.

New conjugates 1–6 containing 5-dFCR and selected hydroxycinnamic acids were synthesized and tested in vitro against pancreatic cancer (PDAC) lines. The ADME properties and molecular docking to CES2 or human albumin were discussed.

Predict SLC6 mutation clinical pathogenicity by calculating the amino acid descriptors in different ranges with rationalization analysis of the prediction.

In this study, we prepare pore-spanning membranes that mimic the composition of plasma membranes and perform force spectroscopy indentation measurements to unravel mechanistic insights depending on lipid composition.

Illustration of the mechanism of NbC/TA–GelMA hydrogel with multifunctional properties for potential application in oral mucosal impairment.

A novel hydrocyanine-based turn-on fluorescence probe HCy-Lyso, with excellent lysosome-targeting ability and ˙OH-responsive efficiency, has been applied for monitoring the variation in lysosomal ˙OH levels during ferroptosis.

HA-coated redox sensitive visualized nano-prodrug HA/TPE-CS-SS-PTX were exploited in order to highly efficient treatment of cancer and real-time monitoring of drug localization.

The use of histone deacetylase inhibitors (HDACis) is an effective approach for cancer treatment.

Analytical technique for monitoring skin-emitted metabolites to diagnose diseases.

WAXS displays a significant difference due to the presence of amyloid fibrils in the absence of sugar.

Red phosphorescent nanoparticles with cell-penetrating peptide non-covalently modification were used for time-resolved imaging.

Zymosan/ι-carrageenan/agarose hydrogel (antitumor) as tumor targeting (M2 to M1 genes) and wound healing material.

A sequence of novel quinoline-8-yloxy and cinnamide hybrids has been synthesized and evaluated for in vitro cytotoxicity against HepG2 liver cancer cells.

Our study introduces novel symmetrical and asymmetrical dihydropyridines as breast cancer inhibitors, showing cytotoxicity against MCF-7 cells and EGFR kinase inhibition. Molecular docking and dynamics validate superior binding to Lapatinib.

An advanced machine learning workflow integrating the gradient boosting decision tree (GB) algorithm and the permutation feature importance (PFI) technique has been proposed to predict the corrosion inhibition efficiency (IE) of organic compounds.

A versatile probe with mitochondria targeting, PN, for detection of viscosity alteration in HIRI mouse model was fabricated. PN had high sensitivity and selectivity, and with a large Stokes shift (∼190 nm) for viscosity. PN is expected to be used for early diagnosis and treatment assessment of HIRI disease, and also provides diagnostic basis for other related diseases.

Novel bioactive pyrido[2,3-d]pyrimidine derivatives with potent apoptotic inducers as PIM-1 kinase inhibitors.

Alzheimer has many crucial factors that should be considered in order to get better results from clinical trials. Benzimidazole and its isosteres represent significant scaffolds for designing potential multi-target anti-alzheimer molecules.

The cWIWLYA peptide shows high labeling efficiency with I-131 (>90%). Its ¹³¹I₂-complex has high stability at room temperature as well as in plasma.

This review summarizes the application of various photothermal materials in the detection of circulating tumor cells (CTCs), and describes the significance of CTCs detection for early tumor diagnosis and tumor prognosis.

A user-friendly LC-MS data-independent acquisition-based strategy using open software for access to the flavonoid content of complex mixtures.

We report deposition of a MgCO₃ coating on titanium surfaces using a hydrothermal method, followed by hydrogen peroxide treatment. The coating demonstrated antibacterial properties and enhanced osteogenic differentiation of BMSC.

This review summarized the function of cancer cell membranes and comprehensively discussed the preparation of cancer cell membrane-coated nanoparticles (CCM-NPs) and their application in anti-tumor therapy. The graphical abstract figure was drawn by Figdraw (https://www.figdraw.com).