RSC Advances
Medical diagnostics articles published in the last
6 months
Precision phenylalanine sensing in blood with nanomaterial-enhanced electrodes
Modified screen-printed gold electrodes (Au-ERGO) increase sensitivity and reduce LOD and LOQ of the quantitation of Phenylalanine in human whole blood.
RSC Adv., 2024,14, 29874-29882
https://doi.org/10.1039/D4RA05045B
A point of care sensor for detection of alcohols, aldehydes and esters in urinary metabolites of war veterans injured by sulfur mustard
To discriminate between different alcoholic, aldehyde, and ester species in urine samples of war veterans who exposed with sulfur mustard with healthy people, a paper-based colorimetric sensor array is introduced.
RSC Adv., 2024,14, 29518-29525
https://doi.org/10.1039/D4RA05461J
Safety evaluation of Plukenetia volubilis seeds: a metabolomic profiling and network toxicology approach
The study indicated the absence of saponins, the presence of phytosterols and trigonellin (a pyridine alkaloid), and a low safety risk related to saponin and alkaloid content in the Sacha Inchi seeds.
RSC Adv., 2024,14, 29319-29329
https://doi.org/10.1039/D4RA03767G
Development of an electrochemical sensor modified with gold nanoparticles for detecting fumonisin B1 in packaged foods
Fumonisin B1 (FB1) is naturally present in the environment and can easily contaminate packaged foods during processing, storage and transportation, and electrochemical detection provides a simple way to obtain sensitive detection results.
RSC Adv., 2024,14, 29254-29259
https://doi.org/10.1039/D4RA04753B
Optimizing workflow efficiency for analyzing low molecular weight endogenous peptides in colostrum
A novel approach to extract EPs from colostrum using peptide extraction methods combined with ultracentrifugation was developed. Over 3200 EPs were extracted from bovine colostrum enabling the identification of less abundant proteins and peptides.
RSC Adv., 2024,14, 29189-29200
https://doi.org/10.1039/D4RA03199G
Surface-enhanced Raman spectroscopy (SERS) for the diagnosis of acute myocardial infarction (AMI) using blood serum samples
Surface-enhanced Raman spectroscopy is employed for the characterization and diagnosis of acute myocardial infarction using blood serum samples.
RSC Adv., 2024,14, 29151-29159
https://doi.org/10.1039/D4RA03816A
Carbon nanomaterials as electrochemical sensors for theophylline: a review
Recent progress in the utilization of nanocarbon-based materials, such as graphene, nanodiamond, and CNTs, is discussed regarding their enhanced performance in electrochemical sensors for theophylline.
RSC Adv., 2024,14, 28927-28942
https://doi.org/10.1039/D4RA03585B
Soft X-ray spectromicroscopy of human fibroblasts with impaired sialin function
A comparative study of normal human fibroblasts and Salla disease patients' fibroblasts reveals changes in the soft X-ray spectroscopic signatures of disease cells. Synchrotron radiation imaging was performed for thin sections and grid-grown cells.
RSC Adv., 2024,14, 28797-28806
https://doi.org/10.1039/D4RA05520A
Characterization of dolomite and calcite microcalcifications in human breast tissue
Microcalcifications within minimally processed tissue sections from breast cancer patients were analyzed. Most of these microcalcifications were calcite and dolomite crystals, with dolomite being observed in tumorous tissue for the first time.
RSC Adv., 2024,14, 28741-28752
https://doi.org/10.1039/D4RA04137B
Bioreceptor modified electrochemical biosensors for the detection of life threating pathogenic bacteria: a review
The lack of reliable and efficient techniques for early monitoring to stop long-term effects on human health is an increasing problem as the pathogenesis effect of infectious bacteria is growing continuously.
RSC Adv., 2024,14, 28487-28515
https://doi.org/10.1039/D4RA04038D
Fluorescence nanoprobes bearing low temperature-derived biochar nanoparticles as efficient quenchers for the detection of single-stranded DNA and 17β-estradiol and their analytical potential
The first application of fluorescent nanoprobes using low-temperature bagasse derived quencher nanoparticles (BQNPs) as effective quenchers for ssDNA and 17-estradiol detection.
RSC Adv., 2024,14, 28077-28085
https://doi.org/10.1039/D4RA03168G
Applications of chemically modified screen-printed electrodes in food analysis and quality monitoring: a review
Disposable adlayer modified screen-printed electrodes have become extremely useful devices for ensuring food safety and quality assessment because of their adaptability, affordability, and convenience of use.
RSC Adv., 2024,14, 27957-27971
https://doi.org/10.1039/D4RA02470B
Tailoring adsorbents for levodopa detection: a DFT study on Pt-encapsulated fullerene systems
Despite its effectiveness in managing the motor symptoms of Parkinson's disease, levodopa therapy is often accompanied by adverse effects that can significantly reduce patients' quality of life.
RSC Adv., 2024,14, 27424-27437
https://doi.org/10.1039/D4RA03526G
A dual-function chromogenic and fluorogenic benzofurazan probe for plazomicin and its innovative utility for development of two microwell assays with high throughput for analysis of drug substance and pharmaceutical formulations
NBD-F was evaluated as a dual-function probe chromogenic and fluorogenic probe and employed in the development of microwell-based photometric and fluorometric assays for the quantitative determination of PLZ in its bulk drug and Zemedri® injections.
RSC Adv., 2024,14, 27215-27226
https://doi.org/10.1039/D4RA04882B
Enhancement of weak signals by applying a suppression method to high-intense methyl and methylene signals of lipids in NMR spectroscopy
In this study, we applied a method of suppression to suppress the intense peaks of methyl and methylene groups to allow detection of weaker peaks in NMR spectroscopy of lipids.
RSC Adv., 2024,14, 26873-26883
https://doi.org/10.1039/D4RA03019B
Pristine and aurum-decorated tungsten ditellurides as sensing materials for VOCs detection in exhaled human breath: DFT analysis
We employed DFT to evaluate the sensing capabilities of Au-decorated WTe2 TMDs nanosheets toward VOCs exhaled in human breath, which can serve as potential biomarkers for detecting specific physiological disorders.
RSC Adv., 2024,14, 26788-26800
https://doi.org/10.1039/D4RA04569F
A new non-destructive method to decipher the origin of organic matter in fossils using Raman spectroscopy
We demonstrate that Raman spectroscopy, coupled with spectral interrogation and multivariate statistical analysis, can be used to discriminate among diverse kerogen-like biosignatures. Our approach can shed new light on the origin of fossil organics.
RSC Adv., 2024,14, 26747-26759
https://doi.org/10.1039/D4RA04364B
Convenient two-step method constructed silicon-based microfluidic chip for fast CYP2C19 SNPs detection
Silicon-based qPCR chips are used for the rapid and efficient detection of SNPs with the same accuracy as commercial PCR instruments.
RSC Adv., 2024,14, 26007-26015
https://doi.org/10.1039/D4RA03913K
Assessing rare earth elements in Indian coal ash using Westcott formalism in NAA and leaching studies
This study employs Westcott formalism coupled with the internal monostandard approach in k0-NAA to assess Rare Earth Elements (REEs) in Indian coal ash samples.
RSC Adv., 2024,14, 25820-25829
https://doi.org/10.1039/D4RA04150J
Electrochemical detection of FTO with N3-kethoxal labeling and MazF cleavage
N6-Methyladenosine (m6A) is a prevalent modification in eukaryotic mRNAs and is linked to various human cancers.
RSC Adv., 2024,14, 25561-25570
https://doi.org/10.1039/D4RA03989K
Coupling of droplet-on-demand microfluidcs with ESI/MS to study single-cell catalysis
Glass chips were implemented to facilitate the coupling of a droplet-on-demand system with ESI/MS, thereby enabling the detection of reactions catalysed by a single yeast cell.
RSC Adv., 2024,14, 25337-25346
https://doi.org/10.1039/D4RA04835K
Exposure to polyethylene microplastics exacerbate inflammatory bowel disease tightly associated with intestinal gut microflora
Polyethylene microplastics (PE MPs) have sparked widespread concern about their possible health implications because of their abundance, pervasiveness in the environment and in our daily life.
RSC Adv., 2024,14, 25130-25148
https://doi.org/10.1039/D4RA04544K
Anti-filarial efficacy of Centratherum anthelminticum: unravelling the underlying mechanisms through biochemical, HRAMS proteomics and MD simulation approaches
The anti-filarial activity of CA against lymphatic filarial parasites was evaluated using ex vivo biochemical, proteomics and in silico approaches.
RSC Adv., 2024,14, 25198-25220
https://doi.org/10.1039/D4RA03461A
Development of an assay for colorimetric and fluorometric detection of H2S
Colorimetric and fluorometric detection of H2S by 2-hydroxy naphthaldehyde derivatives.
RSC Adv., 2024,14, 25071-25076
https://doi.org/10.1039/D4RA04339A
Metal-based non-enzymatic systems for cholesterol detection: mechanisms, features, and performance
Metal based catalysts and electrodes are versatile tools known for their redox properties, catalytic efficiency, and stability under various conditions.
RSC Adv., 2024,14, 24561-24573
https://doi.org/10.1039/D4RA04104F
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