RSC Advances  

The organocatalytic Morita–Baylis–Hillman (MBH) reaction, one of the most significant carbon–carbon bond formations involves the addition of α,β-unsaturated carbonyl compounds to activated alkenes to give α-methylene-β-hydroxycarbonyl compounds.

Twenty-three new derivatives of (R/S)-TDHPM-5-carboxanilide have been synthesized with up to 99% yield. All racemates were separated using chiral HPLC (Prep LC) which provided up to 99.99% purity. AC was determined using circular dichroism spectra.

Rigid planar carbon-bridged oligo(phenylenevinylene)–binaphthyl conjugates and alternating copolymers exhibit high luminescence quantum yield of >0.95, along with circular polarized luminescence dissymmetry factors of up to 1.1 × 10⁻³.

The hydrolytic dynamic kinetic resolution of racemic 3-phenyl-2-oxetanone using a chiral PTC and water-free basic anion exchange resin as the hydroxide ion donor was achieved.

A new chiral phosphine ligand and its diol derivative have been designed and synthesized asymmetrically.

Asymmetric synthesis of warfarin in ESI-microdroplets by using chiral 1,2-diamino organocatalysts.

Chiral phosphoric acid-catalyzed enantioselective synthesis of α-tetrasubstituted (1-indolizinyl) (diaryl)-methanamines has been developed.

An exo-selective Diels–Alder reaction was predicted by a computational approach and was experimentally confirmed by the combined use of a dual-functional acid catalyst, such as phosphoric acid, and the conformationally restricted dienylcarbamate.

A convenient synthesis of enantiopure mixed donor phosphine–phosphite ligands has been developed incorporating P-stereogenic phosphanorbornane and axially chiral bisnaphthols into one ligand structure.

Halichlorine and pinnaic acids are structurally related to natural alkaloids isolated from different marine organisms. This review summarizes the asymmetric synthesis strategies of halichlorine and pinnaic acid using a 6-azaspiro[4.5]decane skeleton as the key intermediate.