RSC Advances  

Subject area
Molecular biology articles published in the last 6 months

6 items
Open Access Paper

Selection, characterization, and biosensing applications of DNA aptamers targeting cyanotoxin BMAA

Scientists have established a connection between environmental exposure to toxins like β-N-methylamino-L-alanine (BMAA) and a heightened risk of neurodegenerative disorders.

Graphical abstract: Selection, characterization, and biosensing applications of DNA aptamers targeting cyanotoxin BMAA
Open Access Paper

Serendipitous N,S-difunctionalization of triazoles with trifluoromethyl-β-diketones: access to regioisomeric 1-trifluoroacetyl-3-aryl-5-(2-oxo-2-arylethylthio)-1,2,4-triazoles as DNA-groove binders

An expedient construction of DNA groove binder; CF3-containing triazoles via regioselective reaction of trifluoromethyl-β-diketones with 3-mercapto[1,2,4]triazoles.

Graphical abstract: Serendipitous N,S-difunctionalization of triazoles with trifluoromethyl-β-diketones: access to regioisomeric 1-trifluoroacetyl-3-aryl-5-(2-oxo-2-arylethylthio)-1,2,4-triazoles as DNA-groove binders
Open Access Paper

Single molecule technique unveils the role of electrostatic interactions in ssDNA–gp32 molecular complex stability

A single-molecule electrophysiology assay was employed using an α-HL nanopore to test the stability of ssDNA and gp32 SSB–protein, in different salt conditions. Low salt and the presence of Zn2+ increases ssDNA–gp32 complex stability.

Graphical abstract: Single molecule technique unveils the role of electrostatic interactions in ssDNA–gp32 molecular complex stability
Open Access Retraction

Retraction: Novel fatty chain-modified GLP-1R G-protein biased agonist exerts prolonged anti-diabetic effects through targeting receptor binding sites

Open Access Paper

Structural modulation of insulin by hydrophobic and hydrophilic molecules

In the bloodstream, insulin interacts with various kinds of molecules, which can alter its structure and modulate its function.

Graphical abstract: Structural modulation of insulin by hydrophobic and hydrophilic molecules
Open Access Paper

Achieving high hybridization density at DNA biosensor surfaces using branched spacer and click chemistry

Surface functionalization of glass involving peptide-based branched spacer and click chemistry allows for efficient covalent conjugation of single-strand DNA to achieve high hybridization density tailored for biosensing applications.

Graphical abstract: Achieving high hybridization density at DNA biosensor surfaces using branched spacer and click chemistry
6 items

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