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Toxicology Research

A new, multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
Impact Factor 3.273 (Partial) 6 Issues per Year
 
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Anna Jirkovska, Jaroslav Roh, Olga Lenčová-Popelová, Eduard Jirkovsky, Katerina Hruskova, Eliska Potuckova, Hana Jansova, Pavlina Haskova, Pavla Martinkova, Tomas Eisner, Marek Kratochvil, Jan Sus, Miloslav Machacek, Lucie Tichotova, Vladimir Gersl, Danuta S Kalinowski, Mark Muller, Des Richardson, Katerina Vavrova, Martin Sterba and Tomas Simunek
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00048C, Paper
Cardiotoxicity is a serious drawback of anthracycline anticancer drugs and dexrazoxane is the only cardioprotective agent with clinically established efficacy. Iron-mediated oxidative stress is traditionally believed to be the primary...
 
Wei Liu, Rui Ning, Rui-Ni Chen, Jin-Hua Hu, Hai-Yan Gui, Yu-Wen Wang, Jie Liu, Gang Hu, Jian Yang and Qinglong Guo
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C4TX00239C, Paper
Gambogic acid (GA) was approved by the Chinese Food and Drug Administration for phase II clinical trials in patients with solid tumors. Recently, combinations of GA and chemotherapeutic agents represents...
 
B. Brabu, S. Haribabu, M. Revathy, S. Anitha, M. Thangapandiyan, K. R. Navaneethakrishnan, C. Gopalakrishnan, S. S. Murugan and T. S. Kumaravel
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00198B, Paper
Biocompatibility on lanthanum oxide nanoparticles (LONP) were investigated. LONP was cytotoxic to balb/3T3 cells via release of ROS. LONP and/or extracts were non-irritant, non-sensitizer and non-mutagenic. LONP extracts did not show acute systemic toxicity. Whereas, LONP exerted hepatotoxicity following oral administration.
 
Angela Maria Falchi, Antonella Rosa, Angela Atzeri, Alessandra Incani, Sandrina Lampis, Valeria Meli, Claudia Caltagirone and Sergio Murgia
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00078E, Paper
Analysis of living cells after staining with organelle-specific dyes shows that monoolein-based cubosome treatment induces accumulation of lipid droplets (green) and mitochondrial (red) hyperpolarization.
 
Zhini He, Huawei Duan, Biao Zhang, Miao Li, Liping Chen, Bo Zhang, Xiaonian Zhu, Chen Gao, Jie Li, Xiao Zhang, Jinmiao Zhang, Shan Wang, Xiaowen Zeng, Daochuan Li, Xiumei Xing, Zhengbao Zhang, Lu Ma, Qing Bai, Caixia Liu, Yongmei Xiao, Yuxin Zheng and Wen Chen
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00013K, Paper
Previous studies have showed an etiologic link between polycyclic aromatic hydrocarbons (PAHs) exposure and lung cancer development. While the tumor suppressor gene RASSF1a is mostly silenced by DNA methylation in...
 
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00040H, Paper
This study aimed to investigate whether prenatal nicotine exposure (PNE) could disrupt fetal kidney development and thereafter induce glomerulosclerosis in adult offspring, and to explore its underlying mechanisms. A rat...
 
Vikas Kumar, F A Al-Abbasi, Amita Verma, Mohd Mujeeb and Firoz Anwar
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00095E, Paper
Umbelliferone β-D-galactopyranoside (UFG) (benzopyrone), is a member of coumarin family, found in many plants exhibiting numerous pharmacological actions. The current experiment was carried out to exemplify the anti-inflammatory potential of...
 
Mohamed Saleh Elgawish, Naoya Kishikawa, Mohamed Abolhasan Helal, Kaname Ohyama and Naotaka Kuroda
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00098J, Communication
The important biological and toxicological roles of quinones could be attributed to their versatile electrophilic and oxidative properties. Quinones are able to Michael addition with cellular thiols such as glutathione...
 
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00068H, Paper
Pro-inflammatory cytokine interleukin-6 promotes dietary carcinogen-mediated DNA damage in 2D and 3D cultured cells by inducing CYP1B1 expression through miR27b downregulation.
 
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00087D, Paper
Exposure of the skin to ultraviolet B radiation causes oxidative stress that results in sunburn, photoaging, and skin cancer.
 
Jiaqi Tang, Ye Yuan, Chenxi Wei, Xiaomei Liao, Junlin Yuan, Eewa Nanberg, Yinping Zhang, Carl-Gustaf Bornehag and Xu Yang
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00250D, Paper
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer commonly used in PVC that may leach into the environment, and has been shown to adversely affect the health of humans and animals.
 
Rachel P. Bulcão, Guilherme B. Bubols, Sabrina N. Nascimento, Bruna Gauer, Elisa Sauer, Marília Baierle, Mariele F. Charão, Angela Moro, Natália Brucker, Franciele A. Bruinsmann, Carlos Schnorr, José C. F. Moreira, Adriana R. Pohlmann, Sílvia S. Guterres and Solange C. Garcia
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00030K, Paper
Among the toxicity mechanisms linked to nanoparticles (NPs), oxidative stress (OS) and inflammation are, in general, presumed to mediate their toxicological responses.
 
Nigel Greene and William Pennie
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00055F, Review Article
Computational approaches offer the attraction of being both fast and cheap to run being able to process thousands of chemical structures in a few minutes. As with all new technology, there is a tendency for these approaches to be hyped up and claims of reliability and performance may be exaggerated. So just how good are these computational methods?
 
Marco E. M. Peluso, Armelle Munnia, Roger W. Giese, Dolores Catelan, Stefano Rocca, Serafina Farigu, Antonio Leoni, Marco Bruzzone, Marcello Ceppi and Annibale Biggeri
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00045A, Paper
The mechanisms by which fluoride produces its toxic effects are still not clear.
 
Ki-Tae Jung, Hak-Ryul Kim, Byung-Hoon Lee, Seong-Hwan Kim, Keum-Young So, Tae-Hun An, Hyun-Young Lee and Seon-Hee Oh
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00007F, Paper
A proposed schematic model of the roles of p38 and JNK MAPK activation in the regulation of Cd-induced autophagy through site-specific phosphorylation in serine and tyrosine residues of GSK3αβ.
 
Viktoria Vágány and Andrew G. Smith
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00011D, Review Article
Genetic variants in haem metabolism enzymes can be predisposition factors for adverse reactions in some individuals. New areas of haem biology may also be associated with idiosyncratic effects which are yet to be identified.
 
Byeong Hwa Yun, Viktoriya S. Sidorenko, Thomas A. Rosenquist, Kathleen G. Dickman, Arthur P. Grollman and Robert J. Turesky
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00052A, Review Article
Aristolochic acids (AA) are human renal carcinogens found in all Aristolochia herbaceous plants, many of which have been used worldwide for medicinal purposes for centuries.
 
Sayantani Chall, Soumya Sundar Mati, Bapi Gorain, Soumyadipta Rakshit and Subhash Chandra Bhattacharya
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00049A, Paper
Toxicological assessment of synthesized and PEG functionalized lanthanum phosphate nanorods.
 
Xu Wang, Shijia Su, Ihsan Awais, Qianying Liu, Dongmei Chen, Zhenli Liu, Yulian Wang and Zonghui Yuan
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00001G, Paper
Diaveridine (DVD), belonging to the class of compounds called diaminopyrimidines, has been widely used as a bacteriostatic agent.
 
Xiaoyan Liu, Yanqiu Liu, Yang Qu, Mengchun Cheng and Hongbin Xiao
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00246F, Paper
A metabolomics approach was used to explore emodin-induced liver cells toxicology and a new mechanism was tentatively proposed.
 
Qingyu Huang, Jie Zhang, Lianzhong Luo, Xiaofei Wang, Xiaoxue Wang, Ambreen Alamdar, Siyuan Peng, Liangpo Liu, Meiping Tian and Heqing Shen
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00003C, Paper
Airborne PM2.5 exposure disturbs citrate cycle, amino acid biosynthesis and metabolism, and glutathione metabolism in A549 cells.
 
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00177J, Paper
The purpose of this research is to investigate the effects of perfluorooctane sulfonate (PFOS) on neuronal apoptosis in the hippocampus of rat offspring, and to elucidate the underlying mechanisms associated with calcium homeostasis.
 
Chiara Di Lorenzo, Alessandro Ceschi, Francesca Colombo, Gianfranco Frigerio, Mario G. Bianchetti, Saskia Lüde, Margot von Dechend, Ermanno Valoti and Patrizia Restani
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00016E, Paper
Ginkgo seed poisoning was confirmed by measuring 4′-O-methyl pyridoxine (MPN) as a serum biomarkers. Picture shows the kinetic of MPN at 14 (B) and 20 (C) hours from intake.
 
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00236A, Review Article
The Ah receptor is a transcription factor that modulates gene expression via interactions with multiple protein partners; these are reviewed, including the novel NC-XRE pathway involving KLF6.
 
Jie Zhou, Li Zhou, Liming Chong, Zhonghui Wang, Qiuling Huang, Yubing Wu, Yang Yang, Aicui Ma, Rong Wang, Juan Jiang, Dawei Yan and Zuyue Sun
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00145A, Paper
High dose of Zishen Yutai pill (ZYP) showed mild maternal toxicity in rat (24 g kg−1 d−1, 96× clinical dose) and no reproductive toxicity in rabbit (6 g kg−1 d−1, 24× clinical dose). ZYP could be safely used at the clinical dose during pregnancy.
 

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