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Journal cover: Toxicology Research

Toxicology Research

A multidisciplinary journal covering high impact research in fundamental, translational and applied areas of toxicology; the official journal of The British Toxicology Society and The Chinese Society of Toxicology
Impact Factor 3.983 6 Issues per Year
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Toxicol. Res., 2016, Accepted Manuscript
DOI: 10.1039/C5TX00250H, Paper
Translation (eukaryotic) initiation factor 3 (eIF3 or TIF3) has been found to be a proto-oncogene in cadmium (Cd) response both in vitro and vivo, but whether eIF3 may serve as...
Kirsty Meldrum, Sameirah Macchiarulo, Timothy W Gant and Martin Oliver Leonard
Toxicol. Res., 2016, Accepted Manuscript
DOI: 10.1039/C5TX00389J, Paper
Polycyclic aromatic hydrocarbons (PAH) including Benzo[a]pyrene have been recognised as important pollutant chemicals with the potential to influence the respiratory system in disease. Airway epithelial cells are an integral component...
Toxicol. Res., 2016, Accepted Manuscript
DOI: 10.1039/C5TX00453E, Paper
Ethyl carbamate (EC) is a multi-site carcinogen in experimental animals and probably carcinogenic to humans (IARC group 2A). The present study was designed to investigate the cytotoxicity effect of EC...
Toxicol. Res., 2016, Accepted Manuscript
DOI: 10.1039/C5TX00425J, Paper
Polycyclic aromatic hydrocarbons (PAHs) and heavy metal/loid(s) are common environmental pollutants. Toxicological interaction data on benzo[a]pyrene (B[a]P) and heavy metal/loid(s) are lacking. In this study, we have determined the combined...
Toxicol. Res., 2016, Accepted Manuscript
DOI: 10.1039/C5TX00463B, Paper
Arsenic trioxide (ATO) is a potent anticancer drug agent but its clinical use is often limited by severe cardiotoxicity. However, its exact mechanism remains poorly understood. In this study, we...
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C6TX90005D, Editorial
Nigel Gooderham, Philippa Ross and Sam Keltie highlight what is new in Toxicology Research.
Yi Cui, Samrat Roy Choudhury and Joseph Irudayaraj
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00454C, Paper
The volatile, water soluble trichloroethylene (TCE) is a hazardous industrial waste and could lead to various health problems through disrupting the interaction between DNA and epigenetic enzymes.
Xinyun Xu, Yuebin Ke, Jianhui Yuan, Yuefeng Liu, Xueyu Li, Desheng Wu, Xiaoyun Qin, Jiyan Mao and Kanlang Mao
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00400D, Paper
Trichloroethylene (TCE) is one of the common organic solvents that has been widely used in cleaning or degreasing of metal products and electronic products.
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00397K, Comment
Recently, Costa et al. published an article about promising biomarkers for estimating the postmortem interval.
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00332F, Paper
Endosulfan exposure induces gene expression shifts and affects cellular process in vascular endothelial cells. Adverse outcomes in cellular response result in endothelial dysfunction, associated with environmental diseases.
Ricardo Jorge Dinis-Oliveira, Félix Carvalho, Isabel Costa, Ricardo Silvestre and Teresa Magalhães
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00461F, Comment
We recognize the importance of the issues raised, but would like to emphasize that these contain some misinterpretations and that most of the points were already discussed in depth in our manuscript particularly in the conclusion section.
Hejing Hu, Qiuling Li, Lizhen Jiang, Yang Zou, Junchao Duan and Zhiwei Sun
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00383K, Paper
Silica nanoparticle-induced toxicity in zebrafish embryos affected expression of 2515 genes. Pathway analysis and Signal-net analysis indicated that the gap junction, vascular smooth muscle contraction, and metabolic pathways, apoptosis, the MAPK signaling pathway, the calcium signaling pathway and the JAK-STAT signaling pathway were the most prominent significant pathways in SiNP-induced toxicity in zebrafish embryos.
Toxicol. Res., 2016, Accepted Manuscript
DOI: 10.1039/C5TX00393H, Paper
Arsenic is a multi-system toxicant. However, the mechanism of arsenic toxicity is not fully clarified and lacks of effective protein biomarkers could be used for arsenic poisoning. This study was...
Yufei Dai, Xiao Zhang, Rong Zhang, Xuezheng Zhao, Huawei Duan, Yong Niu, Chuanfeng Huang, Tao Meng, Meng Ye, Ping Bin, Meili Shen, XIaowei Jia, Haisheng Wang, Shanfa Yu and Yuxin Zheng
Toxicol. Res., 2016, Accepted Manuscript
DOI: 10.1039/C5TX00462D, Paper
Diesel engine exhaust (DEE) is predominant contributor to urban air pollutions. The International Agency for Research on Cancer classified DEE as a group I carcinogen. Inflammatory response is considered to...
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00445D, Paper
A cross-sectional study was conducted in a sample of 571 workers to explore the toxic effect and early sensitive biomarker of the health effects of low-dose benzene exposure (LDBE), as well as the correlation between DNA methylation and the toxic effect of LDBE.
Zheng He, Chunyan Zhu, Hegui Huang, Lian Liu, Linlong Wang, Liaobin Chen, Jacques Magdalou and Hui Wang
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00265F, Paper
Glucocorticoid (GC) is a major factor for fetal tissue maturation and fate decision after birth.
Toxicol. Res., 2016, Accepted Manuscript
DOI: 10.1039/C5TX00432B, Paper
The mechanism of uranium-induced kidney cell cytotoxicity is not fully understood. Nrf2 is a transcription factor which can regulate gene expression of cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) responsible...
Rui Chen, Lin Zhao, Ru Bai, Ying Liu, Liping Han, Zhifang Xu, Feng Chen, Herman Autrup, Dingxin Long and Chunying Chen
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00464K, Paper
AgNPs cause toxic damage by gradually imposing stress impacts on the target organs in mice.
Chen Zhang, Yuan Zhou, Shikai Gu, Zengrui Wu, Wenjie Wu, Changming Liu, Kaidong Wang, Guixia Liu, Weihua Li, Philip W. Lee and Yun Tang
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00294J, Paper
A series of models of hERG blockage were built using five machine learning methods based on 13 molecular descriptors, five types of fingerprints and molecular descriptors combining fingerprints at four blockage thresholds.
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00305A, Paper
Sulfur mustard (SM) is a well known chemical warfare agent that poses a major threat to military personnel and also populace.
Xinming Qi, Chunzhu Li, Chunyong Wu, Cunzhi Yu, Mingxia Liu, Man Gao, Chenggang Li, Hong Yan and Jin Ren
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00409H, Paper
(5R)-5-Hydroxytriptolide (LLDT-8), a novel triptolide derivative, will proceed to phase II clinical trials for the treatment of rheumatoid arthritis and cancer.
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00059A, Paper
Although the effect of NaCl on serum lipid levels and hypertension is well known, the detailed mechanism of lipoprotein metabolism still remains unclear.
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00293A, Review Article
Mycotoxins can be biotransformed by phase I and phase II enzymes in animals. However, most of the mycotoxin at high dosage combined with their metabolites can cause carcinogenesis and various cytotoxicity, such as apoptosis, lipids oxidation and cell cycle arrest, etc., and most of which are related to oxidative stress.
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00391A, Paper
Low-dose chemotherapy drugs initiate defective apoptosis, allowing a small population of cells to escape from cell cycle check points and survive with accumulated genetic damage.
Qian Zhang, Wei Liu, Qiao Niu, Yu Wang, Huimin Zhao, Huifang Zhang, Jing Song, Shuji Tsuda and Norimitsu Saito
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00184F, Paper
With the limited but ongoing usage of perfluorooctane sulfonate (PFOS), the health effects of both PFOS and its alternatives are far from being understood.

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