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Journal cover: Toxicology Research

Toxicology Research

A new, multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
Impact Factor 3.273 (Partial) 6 Issues per Year
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Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00100E, Paper
Inorganic mercury is a major environmental contaminant. The primary site of mercury-induced injury is the kidney due to the uptake of Hg(2+)-conjugated organic anions in the proximal tubule, primary across...
Jen-Yin Goh, Richard Weaver, Nicola Platt, Libby Dixon and Ruth Roberts
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00123D, Paper
We examined the use of in vitro (including in silico) techniques in preclinical safety testing by the pharmaceutical industry between 1980 and 2013 to determine patterns, drivers and challenges in...
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00113G, Paper
The cytotoxicity of mitragynine, the dominant alkaloid of the narcotic-like herb, Mitragyna speciosa Korth (Kratom) involves cell cycle arrest, apoptosis and opiate receptors.
Jun Han, Ting Wang, Le Fu, Liang-Yu Shi, Cheng-Cheng Zhu, Jun Liu, Yu Zhang, Xiang-Shun Cui, Nam-Hyung Kim and Shao-Chen Sun
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00070J, Paper
ZEN affected porcine oocyte maturation and early embryonic development. Oxidative stress, autophagy and apoptosis occurred. Aberrant epigenetic modifications were also observed.
Jun Yan, Zhiqing Lin, Bencheng Lin, Honglian Yang, Wei Zhang, Lei Tian, Huanliang Liu, Huashan Zhang, Xiaohua Liu and Zhuge Xi
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00039D, Paper
Epidemiological studies have demonstrated that nanometre particles in polluted air can increase the risk of CVD, which is dangerous to mankind.
Jia-Liu Wei, Lian-Shuang Zhang, Jing-Jing Wang, Fang-Zi Guo, Yan-Bo Li, Xian-Qing Zhou and Zhi-Wei Sun
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00036J, Paper
Endosulfan induces blood hypercoagulability by causing vWF release from endothelial cell apoptosis in Wistar rats.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00112A, Paper
D-PODO in tumor-bearing mice revealed a 50%–60% inhibition of skin tumor formation and reduced toxicity compared to PODO.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00029G, Paper
Vitamin E has the potential to ameliorate the neurotoxicity of Al2O3-nanoparticles that induce neurodegeneration related phenotypes in C. elegans.
Chunzhu Li, Guozhen Xing, Kazuya Maeda, Chunyong Wu, Likun Gong, Yuichi Sugiyama, Xinming Qi, Jin Ren and Guangji Wang
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00058K, Paper
Triptolide possesses unique immunosuppressive and anti-tumor activities. However, its clinical use is limited by the cumulative toxicity in the testis and the mechanisms are poorly understood.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00006H, Paper
p,p′-Dichlorodiphenyltrichloroethane is able to inhibit the apoptosis of human colorectal adenocarcinoma cells, which may be an important mechanism to contribute to colorectal cancer development.
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00146C, Paper
The kidney is an imperative intention of the toxicity of chemical, xenobiotics, drug and oxidative stress. Umbelliferone (7hydroxycoumarin) compound possesses strong anti-inflammatory and free radical scavenging activity. The intend of...
Soeren Meyer, Georg Raber, Franziska Ebert, Larissa Leffers, Sandra Marie Müller, Mojtaba S Taleshi, Kevin A Francesconi and Tanja Schwerdtle
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00122F, Paper
Arsenic-containing fatty acids are one group of fat-soluble arsenic species (arsenolipids), which are present in marine fish and other seafood. Recently, it has been shown that arsenic-containing hydrocarbons, another group...
Nuan P. Cheah, Jeroen L.A. Pennings, Jolanda P. Vermeulen, Roger W.L. Godschalk, Frederik J. van Schooten and Antoon Opperhuizen
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00213J, Paper
Aldehydes cause gene expression changes for genes associated with cardiovascular disease. Exposure to aldehydes from tobacco smoke needs to be controlled.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00012B, Paper
“Intrauterine programming” involved in the intrauterine origin of prenatal ethanol exposure induced enhanced sensitivity of the HPA axis in female offspring rats fed with high-fat diet.
Nigel Greene and William Pennie
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00055F, Review Article
Computational approaches offer the attraction of being both fast and cheap to run being able to process thousands of chemical structures in a few minutes. As with all new technology, there is a tendency for these approaches to be hyped up and claims of reliability and performance may be exaggerated. So just how good are these computational methods?
Viktoria Vágány and Andrew G. Smith
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00011D, Review Article
Genetic variants in haem metabolism enzymes can be predisposition factors for adverse reactions in some individuals. New areas of haem biology may also be associated with idiosyncratic effects which are yet to be identified.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00236A, Review Article
The Ah receptor is a transcription factor that modulates gene expression via interactions with multiple protein partners; these are reviewed, including the novel NC-XRE pathway involving KLF6.

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