Journal cover: Toxicology Research

Toxicology Research

A new, multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
Impact Factor 3.273 (Partial) 6 Issues per Year
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  • Accepted Manuscripts
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Pan Chen, Sudipta Chakraborty, Tanara V. Peres, Aaron B. Bowman and Michael Aschner
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00127C, Review Article
Manganese (Mn) is neurotoxic, and its effect is mediated by net transport across cell membranes. (WT: the intact dopaminergic (DAergic) neurons in the head of C. elegans, in the absence of Mn exposure; + Mn: the DAergic neurons undergo neurodegeneration upon Mn exposure.)
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00097H, Paper
Mitochondria are the particular target of arsenic (As) in the cell.
Rasmus Foldbjerg, Xiumei Jiang, Teodora Miclăuş, Chunying Chen, Herman Autrup and Christiane Beer
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00110A, Review Article
We review the cellular and molecular mechanisms behind silver nanoparticle toxicity and their intracellular fate. In addition, the role of silver ions in the toxicity of silver nanoparticles is discussed.
Piyasi Mukhopadhyay, Sourav Bhattacharya, Arpita Nandy, Aditi Bhattacharyya, Roshnara Mishra and P. P. Kundu
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00102H, Paper
In the present study, the chronic oral toxicity of chitosan derivates was investigated in the mice model.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00126E, Paper
Administration of AAF by gavage to male rats resulted in formation of several DNA adducts in liver, the pattern of which changed over time and with repair. The cumulative dose of 0.125 mg kg−1 AAF achieved in repeated doses for 16 weeks was a NOAEL for DNA adducts.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00105B, Paper
Real-time label-free techniques combining cell electric sensing supported by inorganic analysis are employed to determine the biological impact of zinc oxide nanoparticles on the selected cell model.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00121D, Paper
In this study, we evaluated reproductive toxic effects of benzo(a)pyrene (BaP) in adult male Wistar rats.
Seth Cunningham, Nicola Partridge, Nicola Platt and Ruth Roberts
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00100A, Paper
This project explored the impact of the pharmaceutical industry’s contribution to published papers relevant to the 3Rs (reduction, refinement and replacement of the use of animals in research) nearly half...
George Edward Johnson, W. Slob, Shareen H. Doak, Mick D Fellows, Bhaskar B Gollapudi, Robert H Heflich, Ben J Rees, Lya G Soeteman-Hernandez, Jatin R Verma, John Wills, Gareth J.S Jenkins and Paul A White
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00118D, Paper
Genetic toxicology testing has a crucial role in the safety assessment of new and existing substances of societal value by reducing/eliminating human exposure to potential somatic and germ cell mutagens....
Marcos Braga, Emerson S. Silva, Eduardo P. Rico, Leticia F. Pettenuzzo, Diogo L. de Oliveira, Renato D. Dias, Joao B. T. Rocha, Maria Elisa Calcagnotto, Robert Tanguay, Diogo Onofre Souza and Denis B. Rosemberg
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00111G, Paper
The study of the effects of diethyldithiocarbamate (DEDTC) in some diseases is in focus for many years. However, DEDTC is a metal chelator that can present neurotoxicity as side effects....
Yufang Zhong, Cen Chen, Xiu Wang, Panpan Guo, xinyu Zhang, Zhiqiang Yu and Jing An
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00108G, Paper
Exposure of hexabromocyclododecane (HBCD) and polychlorinated biphenyls (PCBs) has been proved to result in diversified toxicity including cancerigenesis. The objective of this study was to investigate the influence of HBCD...
Shuzhen Liu, Chunna Yu, Dong Cheng, Xiaoying Han, Ligang Jiang, Rongbin Zheng, Xiaoqian Meng, Tianliang Zhang and Lijun Huo
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00104D, Paper
Recent observations have indicated that polychlorinated biphenyls (PCBs) can reduce the number of antral follicles and increase follicular atresia. However, the effect of PCBs on follicles at each developmental stage...
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00123K, Paper
Nitrogen-doped graphene quantum dots (N-GQDs) are safe for environmental release.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00096J, Paper
The prevalence of allergic diseases around the world has been increasing dramatically in recent years.
Laurence Coquin, Steven J. Canipa, William C. Drewe, Lilia Fisk, Valerie J. Gillet, Mukesh Patel, Jeffrey Plante, Richard J. Sherhod and Jonathan D. Vessey
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00071D, Paper
The discovered patterns are used to develop new structural alerts for mutagenicity in the Derek Nexus expert system.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00116H, Review Article
This review describes the applicability of the Hepatic Reductase Null (HRN) and Reductase Conditional Null (RCN) mouse models to study carcinogen metabolism.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00107A, Paper
Cadmium (Cd) is classified as a human carcinogen probably associated with epigenetic change.
Caixia Liu, Xiumei Xing, Liping Chen, Daochuan Li, Qing Bai, Qing Wang, Haohui Yu, Xiaowen Zeng, Qing Wei, Chen Gao, Zhengbao Zhang, Jingmiao Zhang, Zhini He, Lu Ma, Jie Li, Huawei Duan, Yuxin Zheng, Yongmei Xiao and Wen Chen
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00088A, Paper
Our study identified specific histone modifications that were involved in down regulation of the transcription of AhR, conferring cells resistance to cellular damage.
Xiaoyong Zhang, Meiying Liu, Xiqi Zhang, Fengjie Deng, Cuiying Zhou, Junfeng Hui, Wanyun Liu and Yen Wei
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00066H, Paper
The interaction between carbon nanotubes (CNTs) and tannic acid (TA) as well as the effects of TA adsorption on the dispersibility and biocompatibility of CNTs were evaluated.
Ksenia S. Egorova, Marina M. Seitkalieva, Alexandra V. Posvyatenko and Valentine P. Ananikov
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00079J, Paper
The influence of the structure of cations and anions on the biological activity of ionic liquids is addressed.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00078A, Review Article
Maintenance of cellular integrity is crucial for its physiological function, which is constantly threatened by DNA damage arising from numerous intrinsic and environmental sources.
Izatus Shima Taib, Siti Balkis Budin, Ahmad Rohi Ghazali, Putri Ayu Jayusman, Santhana Raj Louis and Jamaludin Mohamed
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00090K, Paper
Palm oil tocotrienol rich fraction reduced the testicular toxicity effects of fenitrothion by its antioxidant properties, involved in the synthesis of DNA repairing enzymes as well as blocking the HSP70 gene transcription.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00085D, Viewpoint
Emerging scientists joining the field of Toxicology bring with them novel and exciting approaches and models to assess toxicity.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00070F, Paper
In vitro kinetic studies with DFT computations to explain the potential of acrylamide metabolism/toxicity with thiols in vivo.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00092G, Paper
“Two intrauterine programming”, involved in the intrauterine origin of high-fat diet-induced NAFL in female offspring rats, induced by prenatal nicotine exposure.

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