Journal cover: Toxicology Research

Toxicology Research

A new, multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
Impact Factor 3.273 (Partial) 6 Issues per Year
 
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  • Accepted Manuscripts
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Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00147H, Paper
The BCRP (ABCG2) transporter is responsible for the efflux of chemicals from the placenta to the maternal circulation. Inhibition of BCRP activity could enhance exposure of offspring to environmental chemicals...
 
Massimiliano G. Bianchi, Manfredi Allegri, Anna Luisa Costa, Magda Blosi, Davide Gardini, Camilla Del Pivo, Adriele Prina Mello, Luisana Di Cristo, Ovidio Bussolati and Enrico Bergamaschi
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00193A, Paper
Although causing moderate cytotoxicity and inflammatory effects, TiO2 nanoparticles (NP) are considered relatively safe materials. However, it is known that TiO2 NP bind bioactive environmental contaminants, such as bacterial lipopolysaccharide...
 
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00095A, Paper
Sonic hedgehog (Shh)/bone morphogenetic protein 4 (Bmp4) is an androgen-regulated signaling pathway that has been shown to be crucial for embryonic development.
 
Mary C. Catanese, Alexander Suvorov and Laura N. Vandenberg
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00119B, Review Article
Toxicological studies generally view pregnant animals as a conduit through which gestational exposure of offspring to chemicals can be achieved, allowing for the study of developmental toxicity.
 
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00131A, Paper
Our previous study has demonstrated the adverse effects of traffic-related PM2.5 on Caenorhabditis elegans, a non-mammalian toxicological model. In this study, we employed the methods of genetics, gene expression pattern,...
 
alexia daoust, Emmanuel Luc Barbier, Sylvain Bohic, Vasile Stupar, Séverine MAUNOIR-REGIMBAL and Florence Fauvelle
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00135D, Paper
Manganese enhanced MRI (MEMRI) offers many possibilities such as tract tracing of neuronal pathways and functional imaging in vivo. This technique necessitates a direct or indirect acute injection of MnCl2...
 
Francisco Cunha, Gabriel Wallau, Ivanildo Pinho, Mauro Nunes, Nadghia Leite, Saulo Tintino, José Galberto Costa, Margareth Linde Athayde, Aline Boligon, Henrique Dougas M Coutinho, Antonio Batista Pereira, Thais Posser and Jeferson Luis Franco
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00162A, Paper
Eugenia uniflora L. (Myrtaceae family), also known as “pitanga”, is a tree species widely used in popular medicine. Despite the well documented beneficial effects of extracts and essential oils from...
 
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00156G, Paper
Objective The goal of the current study was to investigate the molecular mechanisms of copper nanoparticle (CuNP)-induced hepato- and nephrotoxicity by proteomic analysis that was phenotypically anchored to conventional toxicological...
 
Marcos M. Braga, Emerson S. Silva, Eduardo P. Rico, Leticia F. Pettenuzzo, Diogo L. Oliveira, Renato D. Dias, João B. T. Rocha, Maria Elisa Calcagnotto, Robert L. Tanguay, Diogo O. Souza and Denis B. Rosemberg
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00111G, Paper
DEDTC leads to a buildup of DEDTC in the brain with consequent chelation of reactive Zn and behavioral impairment of zebrafish.
 
Zhi-Hua Liu, Ye Yang, Meng-Meng Ge, Li Xu, Yuqing Tang, Fan Hu, Yi Xu and Hui-Li Wang
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00093E, Paper
Bisphenol-A (BPA) has been implicated in the impairment of brain function, but the mechanism remains elusive. Our previous work have found that developmental BPA exposure impairs dendritic spine formation in...
 
Mingyu Su, Lei Sheng, Xiaoyang Zhao, Ling Wang, Xiaohong Yu, Jie Hong, Bingqing Xu, Dong Liu, Xiao Ze, Yunting Zhu, Hao Jiang, Yi Long, Junling Zhou, Jingwen Cui, Kai Li, Yuguan Ze and Fashui Hong
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00106K, Paper
Background: Titanium dioxide particles (TiO2 NPs) have been widely used in industries and daily life; their potential neurotoxic effects are of great concern. The aim of present study is to...
 
Vinaya M. Phatak and Patricia A. J. Muller
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00117F, Review Article
The relationship between p53, ROS and transition metals.
 
Zhong Yufang, Chen Cen, Wang Xiu, Guo Panpan, Zhang Xinyu, Yu Zhiqiang and An Jing
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00108G, Paper
Exposure to hexabromocyclododecane (HBCD) and polychlorinated biphenyls (PCBs) has been proved to result in diversified toxicity, including cancerogenesis.
 
Seth Cunningham, Nicola Partridge, Nicola Platt and Ruth A. Roberts
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00100A, Paper
An analysis of published literature between 2002 and 2012 demonstrates an increased contribution by the pharmaceutical industry to the 3Rs (reduction, refinement and replacement of animals in research) objective along with increasing collaborative efforts between industry and academic institutions.
 
George E. Johnson, Wout Slob, Shareen H. Doak, Mick D. Fellows, Bhaskar B. Gollapudi, Robert H. Heflich, Ben J. Rees, Lya G. Soeteman-Hernández, Jatin R. Verma, John W. Wills, Gareth J. S. Jenkins and Paul A. White
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00118D, Paper
Genetic toxicology testing has a crucial role in the safety assessment of substances of societal value by reducing human exposure to potential somatic and germ cell mutagens.
 
Shuzhen Liu, Chunna Yu, Dong Cheng, Xiaoying Han, Ligang Jiang, Rongbin Zheng, Xiaoqian Meng, Tianliang Zhang and Lijun Huo
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00104D, Paper
Aroclor 1254 impairs the development of follicle (primordial follicle excluded), possibly via the induction of apoptosis mainly in granulosa cells.
 
Pan Chen, Sudipta Chakraborty, Tanara V. Peres, Aaron B. Bowman and Michael Aschner
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00127C, Review Article
Manganese (Mn) is neurotoxic, and its effect is mediated by net transport across cell membranes. (WT: the intact dopaminergic (DAergic) neurons in the head of C. elegans, in the absence of Mn exposure; + Mn: the DAergic neurons undergo neurodegeneration upon Mn exposure.)
 
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00097H, Paper
Mitochondria are the particular target of arsenic (As) in the cell.
 
Rasmus Foldbjerg, Xiumei Jiang, Teodora Miclăuş, Chunying Chen, Herman Autrup and Christiane Beer
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00110A, Review Article
We review the cellular and molecular mechanisms behind silver nanoparticle toxicity and their intracellular fate. In addition, the role of silver ions in the toxicity of silver nanoparticles is discussed.
 
Piyasi Mukhopadhyay, Sourav Bhattacharya, Arpita Nandy, Aditi Bhattacharyya, Roshnara Mishra and P. P. Kundu
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00102H, Paper
In the present study, the chronic oral toxicity of chitosan derivates was investigated in the mice model.
 
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00126E, Paper
Administration of AAF by gavage to male rats resulted in formation of several DNA adducts in liver, the pattern of which changed over time and with repair. The cumulative dose of 0.125 mg kg−1 AAF achieved in repeated doses for 16 weeks was a NOAEL for DNA adducts.
 
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00121D, Paper
In this study, we evaluated reproductive toxic effects of benzo(a)pyrene (BaP) in adult male Wistar rats.
 
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00123K, Paper
Nitrogen-doped graphene quantum dots (N-GQDs) are safe for environmental release.
 
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00096J, Paper
The prevalence of allergic diseases around the world has been increasing dramatically in recent years.
 
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00116H, Review Article
This review describes the applicability of the Hepatic Reductase Null (HRN) and Reductase Conditional Null (RCN) mouse models to study carcinogen metabolism.
 

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