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Toxicology Research

A new, multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
Impact Factor 3.273 (Partial) 6 Issues per Year
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  • Accepted Manuscripts
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Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C4TX00217B, Paper
High doses of metofluthrin have been shown to produce hepatocellular tumours in rats. Previous in vivo and in vitro mode of action (MOA) studies have demonstrated that metofluthrin induces hepatic...
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00205A, Paper
The main source of exposure to mercury (Hg) as divalent inorganic Hg [Hg(II)] and methylmercury (CH3Hg) is the diet, in which complexes with the amino acid cysteine (Hg–Cys) may be found.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00138A, Paper
GO can extract the lipid bilayer of RBCs membranes, resulting in hemolysis and aberrant forms. In contrast, GQDs just disturb the structure and conformation of the lipid, resulting in only aberrant cells.
Daiandra de Almeida Fagundez, Daniela Freitas Câmara, Willian Goulart Salgueiro, Simone Noremberg, Robson Luiz Puntel, Jacqueline Escobar Piccoli, Solange Cristina Garcia, João Batista Teixeira da Rocha, Michael Aschner and Daiana Silva Ávila
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00120F, Paper
Iron (Fe) exposure, results in multiple biological defects in C. elegans, including reproductive and motor impairment, which may be related to oxidative stress and neuronal damage.
Jia-Long Fang, Michelle M. Vanlandingham, Beth E. Juliar, Greg R. Olson, Ralph E. Patton and Frederick A. Beland
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00152D, Paper
Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol] is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings.
Ilaria Fratoddi, Iole Venditti, Cesare Cametti and Maria Vittoria Russo
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00168K, Review Article
Data on the viability of HeLa cells exposed to functionalized gold nanoparticles have been analyzed on the basis of metrics based on the numerical particle concentration that takes into account both the size and shape of the nanoparticles.
Mahsa Karbaschi, Salvador Macip, Vilas Mistry, Hussein H. K. Abbas, George J. Delinassios, Mark D. Evans, Antony R. Young and Marcus S. Cooke
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00197D, Paper
Classically, the nucleotide excision repair (NER) of cyclobutane pyrimidine dimers (CPD) is a lengthy process (t1/2 > 48 h).
Noé Durán-Figueroa, Jesus Agustin Badillo-Corona, Dean Naisbitt and Jose Luis Castrejon
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C4TX00238E, Review Article
Drug hypersensitivity reactions or drug allergy is a form of serious adverse drug reaction with an immunological aetiology to otherwise safe and effective therapeutic agents. The use of certain classes...
Roger W. L. Godschalk, Nicole Verhofstad, Marcha Verheijen, Carole Lyn Yauk, Joost O. Linschooten, Harry van Steeg, Conny T. van Oostrom, Jan van Benthem and Frederik J. van Schooten
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00114A, Paper
Benzo[a]pyrene induces heritable mutations in male germ cells.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00141A, Paper
The comprehensive identification and mechanistic analysis of reproductive toxicants constitutes one of the major hurdles in the toxicological assessment of chemicals.
Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos and Flix Dias Carvalho
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C4TX00043A, Review Article
The nervous system is a highly complex system, including many cell types with multiple functions, with an intricate anatomy and unique structural and functional characteristics, in which the study of...
Abdullah Al-Ali, Neenu Singh, Bella Manshian, Tom Wilkinson, John Wills, Gareth J. S. Jenkins and Shareen H. Doak
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00175C, Paper
Quantum dots (QD) with varying surface chemistry can have an impact on cellular uptake and a range of indicators for cell perturbation.
Sílvio Terra Stefanello, Edovando José Flores da Rosa, Fernando Dobrachinski, Guilherme Pires Amaral, Nélson Rodrigues de Carvalho, Sônia Cristina Almeida da Luz, Caroline Raquel Bender, Ricardo S. Schwab, Luciano Dornelles and Félix Alexandre Antunes Soares
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00166D, Paper
Hepatic encephalopathy is a common complication of severe acute hepatic failure and has been associated with high short-term mortality rates.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00147H, Paper
The BCRP (ABCG2) transporter is responsible for the efflux of chemicals from the placenta to the maternal circulation.
Francisco Assis Bezerra da Cunha, Gabriel Luz Wallau, Antonio Ivanildo Pinho, Mauro Eugenio Medina Nunes, Nadghia Figueiredo Leite, Saulo Relison Tintino, Galberto Martins da Costa, Margareth Linde Athayde, Aline Augusti Boligon, Henrique Douglas Melo Coutinho, Antonio Batista Pereira, Thais Posser and Jeferson Luis Franco
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00162A, Paper
Eugenia uniflora L. (Myrtaceae family), also known as “pitanga”, is a tree species widely used in popular medicine.
Zhi-Hua Liu, Ye Yang, Meng-Meng Ge, Li Xu, Yuqing Tang, Fan Hu, Yi Xu and Hui-Li Wang
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00093E, Paper
Based on Wnt signaling pathway, this study aims to further mechanistically understand memory alteration after BPA exposure.
Mary C. Catanese, Alexander Suvorov and Laura N. Vandenberg
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00119B, Review Article
Toxicological studies generally view pregnant animals as a conduit through which gestational exposure of offspring to chemicals can be achieved, allowing for the study of developmental toxicity.
Vinaya M. Phatak and Patricia A. J. Muller
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00117F, Review Article
The relationship between p53, ROS and transition metals.
Zhong Yufang, Chen Cen, Wang Xiu, Guo Panpan, Zhang Xinyu, Yu Zhiqiang and An Jing
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00108G, Paper
Exposure to hexabromocyclododecane (HBCD) and polychlorinated biphenyls (PCBs) has been proved to result in diversified toxicity, including cancerogenesis.
George E. Johnson, Wout Slob, Shareen H. Doak, Mick D. Fellows, Bhaskar B. Gollapudi, Robert H. Heflich, Ben J. Rees, Lya G. Soeteman-Hernández, Jatin R. Verma, John W. Wills, Gareth J. S. Jenkins and Paul A. White
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00118D, Paper
Genetic toxicology testing has a crucial role in the safety assessment of substances of societal value by reducing human exposure to potential somatic and germ cell mutagens.
Rasmus Foldbjerg, Xiumei Jiang, Teodora Miclăuş, Chunying Chen, Herman Autrup and Christiane Beer
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00110A, Review Article
We review the cellular and molecular mechanisms behind silver nanoparticle toxicity and their intracellular fate. In addition, the role of silver ions in the toxicity of silver nanoparticles is discussed.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00116H, Review Article
This review describes the applicability of the Hepatic Reductase Null (HRN) and Reductase Conditional Null (RCN) mouse models to study carcinogen metabolism.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00085D, Viewpoint
Emerging scientists joining the field of Toxicology bring with them novel and exciting approaches and models to assess toxicity.
Henrik Klingberg, Lene B. Oddershede, Katrin Loeschner, Erik H. Larsen, Steffen Loft and Peter Møller
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00061G, Paper
Single-particle resolution techniques show that endothelial cells internalise 80 nm unmodified gold nanoparticles by endocytosis with subsequent transport to vesicles.

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