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Toxicology Research

A new, multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
Impact Factor 3.273 (Partial) 6 Issues per Year
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Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00177J, Paper
The purpose of this research is to investigate the effects of perfluorooctane sulfonate (PFOS) on neuronal apoptosis in the hippocampus of rat offspring, and to elucidate the underlying mechanisms associated with calcium homeostasis.
Sayantani Chall, Soumya Sundar Mati, Bapi Gorain, Soumyadipta Rakshit and Subhash Chandra Bhattacharya
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00049A, Paper
Emerging development of rare earth nanotechnology in daily science arouse a serious concern regarding their impact on health care system. Despite of potential uses of rare earth (RE) nanoparticles for...
Chiara Di Lorenzo, Alessandro Ceschi, Francesca Colombo, Gianfranco Frigerio, Mario G. Bianchetti, Saskia Lüde, Margot von Dechend, Ermanno Valoti and Patrizia Restani
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00016E, Paper
Ginkgo seed poisoning was confirmed by measuring 4′-O-methyl pyridoxine (MPN) as a serum biomarkers. Picture shows the kinetic of MPN at 14 (B) and 20 (C) hours from intake.
Xu Wang, Shijia Su, Ihsan Awais, Qianying Liu, Dongmei Chen, Zhenli Liu, Yulian Wang and Zonghui Yuan
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00001G, Paper
Diaveridine (DVD), belonging to diaminopyrimidines, has been widely used as a bacteriostatic agent. To evaluate the reproductive toxicity and teratogenic potential of DVD, different concentrations of DVD were administered to...
xiaoyan liu, Yanqiu Liu, Yang Qu, Mengchun Cheng and Hongbin Xiao
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C4TX00246F, Paper
Emodin is one of the most representative natural anthraquinone polyphenols and the liver is one of the major target organs for drug-induced toxicology. The hepatocyte is frequently affected due to...
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00236A, Review Article
The Ah receptor is a transcription factor that modulates gene expression via interactions with multiple protein partners; these are reviewed, including the novel NC-XRE pathway involving KLF6.
Qingyu Huang, Jie Zhang, Lianzhong Luo, Xiaofei Wang, Xiaoxue Wang, Ambreen Alamdar, Siyuan Peng, Liangpo Liu, Meiping Tian and Heqing Shen
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00003C, Paper
Exposure to airborne fine particulate matter (PM2.5) has been associated with a variety of adverse health effects. However, the molecular mechanisms involved in PM2.5-elicited pulmonary toxicity are still not well...
Emily Pansera Waczuk, Jean Paul Kamdem, Amos Olalekan Abolaji, Daiane Meinerz, Thallita Nascimento, Thais SC Dorow, Aline Boligon, Margareth Linde Athayde, Joao B. T. Rocha and Daiana Avila
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C4TX00122B, Paper
Euphorbia tirucalli, popularly known as “avelós”, is a toxic plant traditionally used as a tea in the Brazilian folk medicine for the treatment of various diseases including antibacterial, antiviral and...
Jie Zhou, Li Zhou, Liming Chong, Zhonghui Wang, Qiuling Huang, Yubing Wu, Yang Yang, Aicui Ma, Rong Wang, Juan Jiang, Dawei Yan and Zuyue Sun
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00145A, Paper
High dose of Zishen Yutai pill (ZYP) showed mild maternal toxicity in rat (24 g kg−1 d−1, 96× clinical dose) and no reproductive toxicity in rabbit (6 g kg−1 d−1, 24× clinical dose). ZYP could be safely used at the clinical dose during pregnancy.
N. Duran-Figueroa, J. A. Badillo-Corona, D. J. Naisbitt and J. L. Castrejon-Flores
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00238E, Review Article
T-cells are activated by different mechanisms in the presence of drugs, metabolites or haptens, and they release several molecules that can be used in the diagnosis of drug hypersensitivity.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00217B, Paper
High doses of metofluthrin have been shown to produce hepatocellular tumours in rats.
Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos and Félix Carvalho
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00043A, Review Article
The nervous system has a highly complex organization, including many cell types with multiple functions, with an intricate anatomy and unique structural and functional characteristics; the study of its (dys)functionality following exposure to xenobiotics, neurotoxicology, constitutes an important issue in neurosciences.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00205A, Paper
The main source of exposure to mercury (Hg) as divalent inorganic Hg [Hg(II)] and methylmercury (CH3Hg) is the diet, in which complexes with the amino acid cysteine (Hg–Cys) may be found.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00138A, Paper
GO can extract the lipid bilayer of RBCs membranes, resulting in hemolysis and aberrant forms. In contrast, GQDs just disturb the structure and conformation of the lipid, resulting in only aberrant cells.
Daiandra de Almeida Fagundez, Daniela Freitas Câmara, Willian Goulart Salgueiro, Simone Noremberg, Robson Luiz Puntel, Jacqueline Escobar Piccoli, Solange Cristina Garcia, João Batista Teixeira da Rocha, Michael Aschner and Daiana Silva Ávila
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00120F, Paper
Iron (Fe) exposure, results in multiple biological defects in C. elegans, including reproductive and motor impairment, which may be related to oxidative stress and neuronal damage.
Jia-Long Fang, Michelle M. Vanlandingham, Beth E. Juliar, Greg R. Olson, Ralph E. Patton and Frederick A. Beland
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00152D, Paper
Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol] is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings.
Ilaria Fratoddi, Iole Venditti, Cesare Cametti and Maria Vittoria Russo
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00168K, Review Article
Data on the viability of HeLa cells exposed to functionalized gold nanoparticles have been analyzed on the basis of metrics based on the numerical particle concentration that takes into account both the size and shape of the nanoparticles.
Mahsa Karbaschi, Salvador Macip, Vilas Mistry, Hussein H. K. Abbas, George J. Delinassios, Mark D. Evans, Antony R. Young and Marcus S. Cooke
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00197D, Paper
Classically, the nucleotide excision repair (NER) of cyclobutane pyrimidine dimers (CPD) is a lengthy process (t1/2 > 48 h).
Roger W. L. Godschalk, Nicole Verhofstad, Marcha Verheijen, Carole Lyn Yauk, Joost O. Linschooten, Harry van Steeg, Conny T. van Oostrom, Jan van Benthem and Frederik J. van Schooten
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00114A, Paper
Benzo[a]pyrene induces heritable mutations in male germ cells.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00141A, Paper
The comprehensive identification and mechanistic analysis of reproductive toxicants constitutes one of the major hurdles in the toxicological assessment of chemicals.
Abdullah Al-Ali, Neenu Singh, Bella Manshian, Tom Wilkinson, John Wills, Gareth J. S. Jenkins and Shareen H. Doak
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00175C, Paper
Quantum dots (QD) with varying surface chemistry can have an impact on cellular uptake and a range of indicators for cell perturbation.
Sílvio Terra Stefanello, Edovando José Flores da Rosa, Fernando Dobrachinski, Guilherme Pires Amaral, Nélson Rodrigues de Carvalho, Sônia Cristina Almeida da Luz, Caroline Raquel Bender, Ricardo S. Schwab, Luciano Dornelles and Félix Alexandre Antunes Soares
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00166D, Paper
Hepatic encephalopathy is a common complication of severe acute hepatic failure and has been associated with high short-term mortality rates.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00147H, Paper
The BCRP (ABCG2) transporter is responsible for the efflux of chemicals from the placenta to the maternal circulation.
Francisco Assis Bezerra da Cunha, Gabriel Luz Wallau, Antonio Ivanildo Pinho, Mauro Eugenio Medina Nunes, Nadghia Figueiredo Leite, Saulo Relison Tintino, Galberto Martins da Costa, Margareth Linde Athayde, Aline Augusti Boligon, Henrique Douglas Melo Coutinho, Antonio Batista Pereira, Thais Posser and Jeferson Luis Franco
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00162A, Paper
Eugenia uniflora L. (Myrtaceae family), also known as “pitanga”, is a tree species widely used in popular medicine.
Zhi-Hua Liu, Ye Yang, Meng-Meng Ge, Li Xu, Yuqing Tang, Fan Hu, Yi Xu and Hui-Li Wang
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00093E, Paper
Based on Wnt signaling pathway, this study aims to further mechanistically understand memory alteration after BPA exposure.

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