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Journal cover: Toxicology Research

Toxicology Research

A new, multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
Impact Factor 3.983 6 Issues per Year
  • Advance Articles
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  • All Recent Articles
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Wentao Xu, Liye Zhu, Tao Yu, Xiaozhe Qi, Bo Yang, Lei Shi, Haoshu Luo, Xiaoyun He and Kunlun Huang
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00104H, Paper
OTA can induce hepatotoxicity. Our previous research has shown that miRNAs play important roles in the OTA-induced hepatotoxicity. And miR-122 is the most abundant miRNA in the liver and involved...
Muthuraman Pandurangan, Gansukh Enkhtaivan and Doo Hwan Kim
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00269A, Paper
In the present study we determined the effects of aspartame at various concentrations on cell viability, morphology, ROS level and DNA in human cervical carcinoma cells over different exposure periods.
Arindam Pramanik, Dipranjan Laha, Sourav Chattopadhyay, Sandeep Kumar Dash, Somenath Roy, Panchanan Pramanik and Parimal Karmakar
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00212E, Paper
Novel CuCO3 nanoparticles induced apoptosis in a human cervical cancer cell line. The folic acid mediated targeting of the CuCO3 receptor was studied in vitro & in vivo.
Biqin Tan, Jing Wang, Mengting Zhao, Yan Hu, Jiajia Wang, Bo Yang, QiaoJun He, Xiao Chun Yang and Qinjie Weng
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00110B, Paper
Previous studies have shown that 5-FU (5-fluorouracil) could cause delayed myelin degeneration by inducing oligodendrocyte death.
Suhua Wang, Yanrong Gao, Lihua Huang, Shanshan Zheng, Chunxia Wang, Yanqin Yu and Keqin Xie
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00075K, Paper
The activation mechanism of the NF-κB signaling pathway in Nd2O3 exposure-induced acute lung inflammation and pneumoconiosis.
Lizhen Jiang, Yanbo Li, Yang Li, Caixia Guo, Yongbo Yu, Yang Zou, Yumei Yang, Yang Yu, Junchao Duan, Weijia Geng, Qiuling Li and Zhiwei Sun
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00118H, Paper
The pre-thrombotic state induced by SiNPs via the interaction between platelet activation, coagulation hyperfunction, anti-coagulation and fibrinolytic resistance.
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00214A, Paper
The development of therapeutic approaches combining efficacy and safety represents an important goal in intestinal inflammation research. Recently, evidences supported dietary polyphenols as useful tools in the treatment and prevention...
Rafael Fracasso, Marilia Baierle, Gabriela Göethel, Anelise Barth, Fernando Freitas, Sabrina Nunes Nascimento, Louise Altknecht, Virgilio Olsen, Karina Paese, Vinicius da Silva, Iran Castro, Michael Andrades, Nadine Clausell, Adriana R Pohlmann, Silvia Staniscuaski Guterres and Solange Cristina Garcia
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00207A, Paper
The nanotoxicology aims to study the safety of nanomaterials, especially towards human exposures. Biodegradable polymeric nanocapsules have been indicated as potential drug carriers applicable for treating several pathologies. Thus, the...
Chun-Hao Tsai, Ming-Hui Yang, Amos Hung, Shou-Cheng Wu, Wen-Chin Chiu, Ming-Feng Hou, Yu-Chang Tyan, Yun-Ming Wang and Shyng-Shiou Yuan
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00280J, Paper
Exposure to arsenic is known as a risk factor in various types of cancer. Apart from its carcinogenic activity, arsenic also shows promoting effects on angiogenesis, a crucial process for...
Ankita Pandey, Abhishek Jauhari, Tanisha Singh, Parul Singh, Nishant Singh, Ankur Kumar Srivastava, Farah Khan, Aditya Bhushan Pant, Devendra Parmar and Sanjay Yadav
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00200A, Paper
Cypermethrin, a pyrethroid pesticide, has been shown to induce neurotoxicity in adult mammals. However, studies are also needed to explore its toxicity in developing brains and understand its mechanism of action in neurons.
Shrika G. Harjivan, Pedro F. Pinheiro, Inês L. Martins, Ana L. Godinho, Riccardo Wanke, Pedro P. Santos, Sofia A. Pereira, Frederick A. Beland, M. Matilde Marques and Alexandra M. M. Antunes
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00176E, Paper
Quinoid electrophiles from the nevirapine metabolites, 2-OH- and 3-OH-nevirapine, react with nitrogen-based bionucleophiles yielding covalent adducts.
A. Ruiz, Lamiaa M. A. Ali, P. R. Cáceres-Vélez, R. Cornudella, M. Gutiérrez, J. A. Moreno, R. Piñol, F. Palacio, M. L. Fascineli, R. B. de Azevedo, M. P. Morales and A. Millán
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00241E, Paper
Hematotoxicity of magnetite nanoparticles with different coatings has been evaluated by determining their safety in vitro and in vivo in a rat model up to 30 days.
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00127G, Paper
As one of the most frequently used quantum dots (QDs), the toxicity of cadmium telluride (CdTe) QDs related to several body systems have been investigated, but the studies on the...
Feifei Feng, Yongli Yang, Zhitao Li, Jinyan Song, Hansong Zhu, Lixia Wang, Yong Zhao, Dong Xu, Yongjun Wu, Yiming Wu and Wei Wang
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00121H, Paper
Coal tar pitch is a confirmed human carcinogen and is composed mainly of polycyclic aromatic hydrocarbons.
Jiutao Wang, Lingzhen Song, Kaikai Li, Runchuan Yan, Xinde Hu, Wei Zhang, Yupeng Yin and Shanting Zhao
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00071H, Paper
Occupational and environmental exposures to lead (Pb), one of the toxic metal pollutants, is of global concern.
Ya-Chun Huang, Hsin-Su Yu and Chee-Yin Chai
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00218K, Paper
This study revealed that arsenic regulates SLC25A12, PSME3, vinculin, QR and STIP1 expressions through activation of the ERK-signaling pathway.
Di Liang, Yan Wang, Zhonghui Zhu, Gengxia Yang, Guoliang An, Xiaoli Li, Piye Niu, Li Chen and Lin Tian
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00159E, Paper
BMP-7 exerts an inhibitory effect on silica induced fibrosis in RLE-6TN cells via suppressing TGF-β signaling and activating BMP signaling.
Paul N. Sanderson, Wendy Simpson, Richard Cubberley, Maja Aleksic, Stephen Gutsell and Paul J. Russell
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00246J, Paper
The effectiveness of NMR spectroscopy is demonstrated for the characterisation of Molecular Initiating Events in TT21C-aligned approaches to risk assessments.
Ashley J. Broom, Jeffrey Ambroso, Gino Brunori, Angie K. Burns, James R. Armitage, Ian Francis, Mitul Gandhi, Richard A. Peterson, Timothy W. Gant, Alan R. Boobis and Jonathan J. Lyon
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00197H, Paper
Schematic showing the toxicological and adaptive effects of drug-induced respiratory chain inhibition in vivo; also highlighting unanticipated differences from observations made in vitro (in red).
Junnian Yang, Yunli Zhao, Yanwen Wang, Haifang Wang and Dayong Wang
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00137D, Paper
G-COOH in the range of mg L−1 did not cause toxic effects on both the exposed nematodes and their progeny.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00284B, Paper
The possibility that Cd may activate AhR indirectly via ERK1/2 phosphorylation was tested as a function of enterocytic differentiation status in the human Caco-2 cells.
Patricia Erebi Tawari, Zhipeng Wang, Mohammad Najlah, Chi Wai Tsang, Vinodh Kannappan, Peng Liu, Christopher McConville, Bin He, Angel L. Armesilla and Weiguang Wang
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00210A, Communication
The anticancer activity of disulfiram (DS) is copper(II) (Cu)-dependent.
Isabel Costa, Félix Carvalho, Teresa Magalhães, Paula Guedes de Pinho, Ricardo Silvestre and Ricardo Jorge Dinis-Oliveira
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00209E, Paper
A linear correlation between blood putrefaction time and biochemical parameter concentrations was obtained. Two mathematical models that may have predictive value for estimation of the postmortem interval were developed. The obtained results might be complementary procedures for the methodologies already used.
Ifigeneia V. Mavragani, Danae A. Laskaratou, Benjamin Frey, Serge M. Candéias, Udo S. Gaipl, Katalin Lumniczky and Alexandros G. Georgakilas
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00222B, Review Article
Organisms respond to exogenous threats and insults by a potent inflammatory and immune response, aimed at preserving tissue integrity and restoring tissue homeostasis and function.
Mehriban Ulusoy, Antonina Lavrentieva, Johanna-Gabriela Walter, Franziska Sambale, Mark Green, Frank Stahl and Thomas Scheper
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00236B, Paper
Three-dimensional hAD-MSCs spheroid cultures, with the ability to resemble closely in vivo tissue structures, were assessed for evaluation of dose-dependent cytotoxicity effects of CdTe/CdS/ZnS quantum dots.

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