Journal cover: Toxicology Research

Toxicology Research

A new, multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
 
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Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00030G, Paper
Effect of taurine of propidium iodine staining on nano copper induced liver tissue.
 
Xiaoqing Guo, Suhui Zhang, Stacey L Dial, Mary D. Boudreau, Xingsu Xia, Peter P Fu, Dan D Levy, Martha M Moore and NAN MEI
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00053F, Paper
A 2-year cancer bioassay in rodents with a preparation of Aloe vera whole leaf extract administered in drinking water showed clear evidence of carcinogenic activity. To provide insight into the...
 
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C4TX00064A, Paper
Abstract Sexually matured albino rats were orally treated with sodium cyanide, NaCN (0, 0.64, 1.2 and 3.2 mg/kg BW) for 90 days. After 90 days of treatment, the rats were...
 
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00059E, Communication
This is the first report on in vitro kinetic studies and DFT calculations on the interaction between acrylamide and captopril, which has implications on human health.
 
Wenchao Ai, Yan Huo, Xiaomeng Liu, Fang Liu, Xiaobing Zhou, Yufa Miao, Hua Jiang, Lin Zhang, Lianzhong Shen, Jinhua Piao and Bo Li
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00015C, Paper
Our immunotoxicity model in an animal host indicates that cytokine production and KLH TDAR are very sensitive parameters for defining an agent as immunotoxic, whereas immunophenotyping is less sensitive.
 
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00033A, Paper
The toxicological impacts of the increasing number of synthetic compounds present in the aquatic environment are assessed predominantly in laboratory studies where test organisms are exposed to a range of compounds.
 
Rachel J. Church, J. Eric McDuffie, Manisha Sonee, Monicah Otieno, Jing Ying Ma, Xuejun Liu, Paul B. Watkins and Alison H. Harrill
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00051J, Paper
Increased microRNA-34c-3p appeared as a novel biomarker for doxorubicin nephrotoxicity in rats; alterations showed greater specificity than and comparable sensitivity to albuminuria for early prediction of glomerular injury.
 
Evrim Arzu Koçkaya, Aysun Kılıç Süloğlu, Elif Karacaoğlu and Güldeniz Selmanoğlu
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00037D, Paper
Vinclozolin administration effects: placenta, fetal tissues and skeletal measurements during pregnancy.
 
Jilei Yin, Cheng Kang, Yufeng Li, Qinnuan Li, Xiaoyong Zhang and Wenxin Li
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00040D, Paper
The biodistribution and respiratory toxicity of TiO2 nanoparticle aerogel to mice after whole body inhalation exposure were evaluated.
 
Qi-bing Zeng, Yu-yan Xu, Xian Yu, Jun Yang, Feng Hong and Ai-hua Zhang
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00038B, Paper
Chronic exposure to combined fluoride and arsenic continues to be a major public health problem worldwide, affecting thousands of people. The results clearly show that the combined effect of fluoride and arsenic on renal function is mainly antagonism at these exposure levels.
 
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00032C, Paper
The inadequacy to replace acetaminophen (APAP) with a more effective analgesic continues its use in therapeutic interventions, upholding the risk of hepatotoxicity.
 
Marco E. M. Peluso, Armelle Munnia, Mirko Tarocchi, Roger W. Giese, Laura Annaratone, Gianni Bussolati and Roberto Bono
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00046C, Paper
An experimental study on how formaldehyde-fixation is capable of inducing excess oxidative DNA damage in formalin-fixed paraffin-embedded tissues.
 
Dilek Guvenc, Abdurrahman Aksoy, Ayhan Gacar, Enes Atmaca, Kursad Y. Das and Tolga Guvenc
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00041B, Paper
The aim of this study was to evaluate monoamine and mitochondrial cytochrome c levels and lipid peroxidation in adult male rats treated with cyfluthrin (14 mg kg−1 dose; approximately 1/10 of the LD50 value) for 14 days. This study also examined cyfluthrin induced-apoptosis via the signaling proteins Bcl-2, caspase-9 and caspase-3, and possible anti-apoptotic effects of Alfa-basic crystallin.
 
Marlies Unterberg, Larissa Leffers, Florian Hübner, Hans-Ulrich Humpf, Konstantin Lepikhov, Jörn Walter, Franziska Ebert and Tanja Schwerdtle
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00036F, Paper
This study aims to further mechanistically understand toxic modes of action after chronic arsenic species exposure.
 
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00019F, Communication
Toxicity of hydroxymethylfurfural and 21 derivatives was assessed. Important guidelines for selection of more human friendly building blocks were obtained.
 
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00006D, Paper
Imidacloprid (IMI) and clothianidin (CTD) are the most important of the neonicotinoid insecticides known to target the nicotinic acetylcholine receptor (nAChR) in insects and, potentially, in mammals.
 
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00011K, Review Article
The cardiovascular benefits and risks of fish consumption depend on the ratio of n-3 PUFAs to MeHg. Fish species that are both high in n-3 PUFAs and low in MeHg have beneficial effects on the cardiovascular system.
 
Abeer H. A. Amer, Richard J. Wall, Sunir Malla, Fei Sang, Aziz Aboobaker, Simon V. Avery, Ian R. Mellor, Martin D. Rose, J. Craig Rowlands, Timothy W. Gant and David R. Bell
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C3TX50110H, Paper
The mechanism of induction of hepatic DNA synthesis by PPARα agonists and other hepatic growth agents was investigated using transcriptomic approaches.
 
Zhiqing Lin, Zhuge Xi and Jiehua Huang
Toxicol. Res., 2014, Accepted Manuscript
DOI: 10.1039/C3TX50059D, Paper
Background: Carbon nanotube (CNT) mediated drug delivery systems have currently aroused a great deal of interest. Such delivery systems for drugs, proteins and genes have been preliminarily studied using cellular...
 

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