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Journal cover: Toxicology Research

Toxicology Research

A new, multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
Impact Factor 3.273 (Partial) 6 Issues per Year
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B Brabu, S Haribabu, M Revathy, S Anitha, M Thangapandiyan, K R Navaneethakrishnan, C Gopalakrishnan, S s Murugan and T S Kumaravel
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C4TX00198B, Paper
Lanthanum oxide nanoparticles (LONP), a rare earth metal oxide has unique properties that make it a suitable candidate for several biomedical applications. We investigated certain key in vitro and in...
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00087D, Paper
Exposure of the skin to ultraviolet B radiation causes oxidative stress that results in sunburn, photoaging, and skin cancer.
Jiaqi Tang, Ye Yuan, Chenxi Wei, Xiaomei Liao, Junlin Yuan, Eewa Nanberg, Yinping Zhang, Carl-Gustaf Bornehag and Xu Yang
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00250D, Paper
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer commonly used in PVC that may leach into the environment, and has been shown to adversely affect the health of humans and animals.
Angela Maria Falchi, A. Rosa, Angela Atzeri, Alessandra Incani, Sandrina Lampis, Valeria Meli, Claudia Caltagirone and Sergio Murgia
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00078E, Paper
Despite the remarkable development of nanoparticles for different purposes, relatively little is known about their interaction with biological systems and individual cells. Here the effects of two monoolein-based cubosome formulations...
Rachel P. Bulcão, Guilherme B. Bubols, Sabrina N. Nascimento, Bruna Gauer, Elisa Sauer, Marília Baierle, Mariele F. Charão, Angela Moro, Natália Brucker, Franciele A. Bruinsmann, Carlos Schnorr, José C. F. Moreira, Adriana R. Pohlmann, Sílvia S. Guterres and Solange C. Garcia
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00030K, Paper
Among the toxicity mechanisms linked to nanoparticles (NPs), oxidative stress (OS) and inflammation are, in general, presumed to mediate their toxicological responses.
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00068H, Paper
Colorectal cancer (CRC) is the third most common cancer worldwide with 80% of cases being sporadic, arising following a series of environment-induced gene mutations. DNA damaging pro-carcinogens such as benzo[a]pyrene...
Nigel Greene and William Pennie
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00055F, Review Article
Computational approaches offer the attraction of being both fast and cheap to run being able to process thousands of chemical structures in a few minutes. As with all new technology, there is a tendency for these approaches to be hyped up and claims of reliability and performance may be exaggerated. So just how good are these computational methods?
Marco E. M. Peluso, Armelle Munnia, Roger W. Giese, Dolores Catelan, Stefano Rocca, Serafina Farigu, Antonio Leoni, Marco Bruzzone, Marcello Ceppi and Annibale Biggeri
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00045A, Paper
The mechanisms by which fluoride produces its toxic effects are still not clear.
Ki-Tae Jung, Hak-Ryul Kim, Byung-Hoon Lee, Seong-Hwan Kim, Keum-Young So, Tae-Hun An, Hyun-Young Lee and Seon-Hee Oh
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00007F, Paper
A proposed schematic model of the roles of p38 and JNK MAPK activation in the regulation of Cd-induced autophagy through site-specific phosphorylation in serine and tyrosine residues of GSK3αβ.
Viktoria Vágány and Andrew G. Smith
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00011D, Review Article
Genetic variants in haem metabolism enzymes can be predisposition factors for adverse reactions in some individuals. New areas of haem biology may also be associated with idiosyncratic effects which are yet to be identified.
Byeong Hwa Yun, Viktoriya S. Sidorenko, Thomas A. Rosenquist, Kathleen G. Dickman, Arthur P. Grollman and Robert J. Turesky
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00052A, Review Article
Aristolochic acids (AA) are human renal carcinogens found in all Aristolochia herbaceous plants, many of which have been used worldwide for medicinal purposes for centuries.
Sayantani Chall, Soumya Sundar Mati, Bapi Gorain, Soumyadipta Rakshit and Subhash Chandra Bhattacharya
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00049A, Paper
Toxicological assessment of synthesized and PEG functionalized lanthanum phosphate nanorods.
Xu Wang, Shijia Su, Ihsan Awais, Qianying Liu, Dongmei Chen, Zhenli Liu, Yulian Wang and Zonghui Yuan
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00001G, Paper
Diaveridine (DVD), belonging to the class of compounds called diaminopyrimidines, has been widely used as a bacteriostatic agent.
Xiaoyan Liu, Yanqiu Liu, Yang Qu, Mengchun Cheng and Hongbin Xiao
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00246F, Paper
A metabolomics approach was used to explore emodin-induced liver cells toxicology and a new mechanism was tentatively proposed.
Qingyu Huang, Jie Zhang, Lianzhong Luo, Xiaofei Wang, Xiaoxue Wang, Ambreen Alamdar, Siyuan Peng, Liangpo Liu, Meiping Tian and Heqing Shen
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00003C, Paper
Airborne PM2.5 exposure disturbs citrate cycle, amino acid biosynthesis and metabolism, and glutathione metabolism in A549 cells.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00177J, Paper
The purpose of this research is to investigate the effects of perfluorooctane sulfonate (PFOS) on neuronal apoptosis in the hippocampus of rat offspring, and to elucidate the underlying mechanisms associated with calcium homeostasis.
Chiara Di Lorenzo, Alessandro Ceschi, Francesca Colombo, Gianfranco Frigerio, Mario G. Bianchetti, Saskia Lüde, Margot von Dechend, Ermanno Valoti and Patrizia Restani
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00016E, Paper
Ginkgo seed poisoning was confirmed by measuring 4′-O-methyl pyridoxine (MPN) as a serum biomarkers. Picture shows the kinetic of MPN at 14 (B) and 20 (C) hours from intake.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00236A, Review Article
The Ah receptor is a transcription factor that modulates gene expression via interactions with multiple protein partners; these are reviewed, including the novel NC-XRE pathway involving KLF6.
Jie Zhou, Li Zhou, Liming Chong, Zhonghui Wang, Qiuling Huang, Yubing Wu, Yang Yang, Aicui Ma, Rong Wang, Juan Jiang, Dawei Yan and Zuyue Sun
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00145A, Paper
High dose of Zishen Yutai pill (ZYP) showed mild maternal toxicity in rat (24 g kg−1 d−1, 96× clinical dose) and no reproductive toxicity in rabbit (6 g kg−1 d−1, 24× clinical dose). ZYP could be safely used at the clinical dose during pregnancy.
N. Duran-Figueroa, J. A. Badillo-Corona, D. J. Naisbitt and J. L. Castrejon-Flores
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00238E, Review Article
T-cells are activated by different mechanisms in the presence of drugs, metabolites or haptens, and they release several molecules that can be used in the diagnosis of drug hypersensitivity.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00217B, Paper
High doses of metofluthrin have been shown to produce hepatocellular tumours in rats.
Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos and Félix Carvalho
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00043A, Review Article
The nervous system has a highly complex organization, including many cell types with multiple functions, with an intricate anatomy and unique structural and functional characteristics; the study of its (dys)functionality following exposure to xenobiotics, neurotoxicology, constitutes an important issue in neurosciences.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00205A, Paper
The main source of exposure to mercury (Hg) as divalent inorganic Hg [Hg(II)] and methylmercury (CH3Hg) is the diet, in which complexes with the amino acid cysteine (Hg–Cys) may be found.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00138A, Paper
GO can extract the lipid bilayer of RBCs membranes, resulting in hemolysis and aberrant forms. In contrast, GQDs just disturb the structure and conformation of the lipid, resulting in only aberrant cells.
Daiandra de Almeida Fagundez, Daniela Freitas Câmara, Willian Goulart Salgueiro, Simone Noremberg, Robson Luiz Puntel, Jacqueline Escobar Piccoli, Solange Cristina Garcia, João Batista Teixeira da Rocha, Michael Aschner and Daiana Silva Ávila
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00120F, Paper
Iron (Fe) exposure, results in multiple biological defects in C. elegans, including reproductive and motor impairment, which may be related to oxidative stress and neuronal damage.

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