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Journal cover: Toxicology Research

Toxicology Research

A new, multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
Impact Factor 3.983 6 Issues per Year
  • Advance Articles
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  • Accepted Manuscripts
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  • All Recent Articles
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Narmada Bag, Rashi Mathur, Firasat Hussain, Namita Indracanti, Sweta Singh, Shivani Singh, Ram Prakash Chauhan, Krishna Chuttani and Anil Kumar Mishra
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00090D, Paper
Synthesis and in vivo toxicity assessment of radiolabeled Bis-ligand functionalized core shell quantum dot.
Olga Gladkovskaya, Paul Greaney, Yurii K. Gun'ko, Gerard M. O'Connor, Martin Meere and Yury Rochev
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00149H, Paper
Scheme represents the model approach. After exposure to quantum dots initial cell population may follow various pathways which depend on intracellular concentration of quantum dots.
Yanhong Lou, Junsong Wang, Ge Dong, Pingping Guo, Dandan Wei, Sai-Sai Xie, Ming-Hua Yang and Ling-Yi Kong
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00096C, Paper
Tacrine is a well-known acetylcholinesterase inhibitor used for the treatment of Alzheimer’s disease (AD). Unfortunately, occurrence of hepatotoxicities was found in about 30% of patients taking tacrine at its therapeutic...
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00196J, Paper
Inorganic arsenic promotes SV-HUC-1 cells proliferation.
Wenxue Li, Liping Chen, Yiwei Su, Hua Yin, Yaqin Pang and Zhixiong Zhuang
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00056D, Paper
1,2-Dichloroethane (DCE) decreased kidney cell proliferation, even induced cell apoptosis via increasing the generation of ROS in the presence of an extra-metabolic system.
Ming-Hui Li, Ling-Yu Ruan, Yan Liu, Hua-Dong Xu, Ting Chen, Yong-Hong Fu, Lei Jiang and Jun-Song Wang
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00115C, Paper
AVM disturbed the metabolomic profiles of goldfish dose-dependently, affecting the metabolic pathways related with its toxicity.
Mang Li, Jing Cui, Yanhui Gao, Wei Zhang, Liyan Sun, Xiaona Liu, Yang Liu and Dianjun Sun
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00050E, Paper
The aim of this study is to establish a single and combined intoxication model of fluoride and aluminum so as to observe the impact of these chemicals on the learning and memory ability and the pathologic changes in the brains of rats.
Shu Lin Zhuang, Ling Ling Bao, Hai Fei Wang, Min Zhang, Chang Yang, Xin Yi Zhou, Yuan Wu, Kanwal Rehman and Hua Naranmandura
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00093A, Paper
Difenoconazole is one of the triazole compounds, and is widely used as an environmental fungicide.
Yue Pan, Zheng Wang, Dan Shao, Huilin Zheng, Yujing Chen, Xiao Zheng, Ming Zhang, Jing Li, Feng Li and Li Chen
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00227J, Paper
CTAB induced mitochondrial apoptosis by activating the AMPK-p53 pathway in hepatocarcinoma cells.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00101C, Paper
The aim of the present investigation was to study the events associated with palmitic acid induced metabolic and lipotoxic changes in human hepatoma cells (Hep3B, Huh7 and HepG2).
Anthony M. Lynch, Matthew Cleveland, Rabinder Prinjha, Umesh Kumar, Robert Stubbs and Jens Wuerthner
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00179J, Paper
Ozanezumab (GSK1223249) is a humanised, Fc-disabled, monoclonal antibody (mAb) which targets the amino terminus of Neurite Outgrowth Inhibitor A (Nogo-A) which is currently being developed for the treatment of amyotrophic lateral sclerosis (ALS).
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00100E, Paper
Furosemide improves HgCl2-induced tubule injury up-regulating Oat1 and Mrp2, thus increasing renal elimination of mercuric ions.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00146C, Paper
Umbelliferone (7-hydroxycoumarin) compound possesses strong anti-inflammatory and free radical scavenging activity.
Ki-Tae Jung, Hak-Ryul Kim, Byung-Hoon Lee, Seong-Hwan Kim, Keum-Young So, Tae-Hun An, Hyun-Young Lee and Seon-Hee Oh
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX90016F, Correction
Jen-Yin Goh, Richard J. Weaver, Libby Dixon, Nicola J. Platt and Ruth A. Roberts
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00123D, Paper
An analysis of the use of in vitro techniques in preclinical safety testing revealed a marked increase to >180 000 tests/year by 2012. Step changes in uptake were notable in the three main areas of ADME, safety pharmacology and genetic toxicology, correlated with relevant ICH guidelines.
S. Meyer, G. Raber, F. Ebert, L. Leffers, S. M. Müller, M. S. Taleshi, K. A. Francesconi and T. Schwerdtle
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00122F, Paper
Arsenic-containing fatty acids are bioavailable and toxic to human liver cells in culture.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00113G, Paper
The cytotoxicity of mitragynine, the dominant alkaloid of the narcotic-like herb, Mitragyna speciosa Korth (Kratom) involves cell cycle arrest, apoptosis and opiate receptors.
Jun Han, Ting Wang, Le Fu, Liang-Yu Shi, Cheng-Cheng Zhu, Jun Liu, Yu Zhang, Xiang-Shun Cui, Nam-Hyung Kim and Shao-Chen Sun
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00070J, Paper
ZEN affected porcine oocyte maturation and early embryonic development. Oxidative stress, autophagy and apoptosis occurred. Aberrant epigenetic modifications were also observed.
Jun Yan, Zhiqing Lin, Bencheng Lin, Honglian Yang, Wei Zhang, Lei Tian, Huanliang Liu, Huashan Zhang, Xiaohua Liu and Zhuge Xi
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00039D, Paper
Epidemiological studies have demonstrated that nanometre particles in polluted air can increase the risk of CVD, which is dangerous to mankind.
Jia-Liu Wei, Lian-Shuang Zhang, Jing-Jing Wang, Fang-Zi Guo, Yan-Bo Li, Xian-Qing Zhou and Zhi-Wei Sun
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00036J, Paper
Endosulfan induces blood hypercoagulability by causing vWF release from endothelial cell apoptosis in Wistar rats.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00112A, Paper
D-PODO in tumor-bearing mice revealed a 50%–60% inhibition of skin tumor formation and reduced toxicity compared to PODO.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00029G, Paper
Vitamin E has the potential to ameliorate the neurotoxicity of Al2O3-nanoparticles that induce neurodegeneration related phenotypes in C. elegans.
Chunzhu Li, Guozhen Xing, Kazuya Maeda, Chunyong Wu, Likun Gong, Yuichi Sugiyama, Xinming Qi, Jin Ren and Guangji Wang
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00058K, Paper
Triptolide possesses unique immunosuppressive and anti-tumor activities. However, its clinical use is limited by the cumulative toxicity in the testis and the mechanisms are poorly understood.
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00006H, Paper
p,p′-Dichlorodiphenyltrichloroethane is able to inhibit the apoptosis of human colorectal adenocarcinoma cells, which may be an important mechanism to contribute to colorectal cancer development.
Nuan P. Cheah, Jeroen L.A. Pennings, Jolanda P. Vermeulen, Roger W.L. Godschalk, Frederik J. van Schooten and Antoon Opperhuizen
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00213J, Paper
Aldehydes cause gene expression changes for genes associated with cardiovascular disease. Exposure to aldehydes from tobacco smoke needs to be controlled.

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