Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
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Pratik A Ambasana, Dipak D Vachhani, Marzia Galli, Jeroen Jacobs, Luc Van Meervelt, Anamik shah and Erik V�lery Van der Eycken
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01644K, Paper
The tuning of selective ring closure is a nontrivial challenge in synthetic organic chemistry. Herein we report a solvent switchable metal-free [4+2] cycloaddition approach via Csp2–H functionalization. The protocol is...
John C. Lukesh, Kristen A. Andersen, Kelly K. Wallin and Ronald T. Raines
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01738B, Communication
Organocatalysts derived from diethylenetriamine effect the rapid isomerization of non-native protein disulfide bonds to native ones. These catalysts contain a pendant hydrophobic moiety to encourage interaction with the non-native state,...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01659A, Paper
The conformations of a series of benziporphyrins, naphthiporphyrins, oxybenziporphyrins, and related structures were minimized using DFT-B3LYP/6-311++G(d,p). The relative stabilities of the tautomers for each series were also calculated using M06-2X...
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01858C, Communication
A novel direct synthesis of pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones from α-hydroxy ketones and dimethyl but-2-ynedioate via a base-promoted cascade annulation has been developed.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01394H, Paper
Simultaneous emission from the Trp and Dns fluorophores of linked dyads in biomimetic media is quenched by iodide anions with rate constants that depend on the local hydrophobicity.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01594K, Paper
Direct C–H arylation of fluorenes with aryl chlorides and transformation of the products in a one-pot procedure was reported.
Yogesh Daulat Dhage, Hiroki Daimon, Cheng Peng, Taichi Kusakabe, Keisuke Takahashi, Yuichiro Kanno, Yoshio Inouye and Keisuke Kato
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01576B, Paper
A simple change of the ligand and solvent allows controlled, effective switching between cyclization–carbonylation–cyclization-coupling (CCC-coupling) and cyclization–carbonylation reactions.
Rong-Rong Zhang, Hai-Yan Tian, Ya-Fang Tan, Tse-Yu Chung, Xiao-Hui Sun, Xue Xia, Wen-Cai Ye, David Middleton, Natalya Fedosova, Mikael Esmann, Jason T.C. Tzen and Renwang Jiang
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01545B, Paper
Five new cardenolide lactates (1-5) and one new dioxane double linked cardenolide glycoside (17) along with 15 known compounds (6-16 and 18-21) were isolated from the ornamental milkweed Asclepias curassavica....
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01618A, Review Article
2-Alkynylbenzaldoxime as a versatile building block has been applied widely for the construction of N-heterocycles in organic synthesis. Since it could be easily transferred to isoquinoline N-oxide via intramolecular 6-endo...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01299B, Paper
A novel colorimetric probe (P4) for the selective differential detection of DFP (a Sarin and Soman mimic) and DCNP (a Tabun mimic) was prepared. Probe P4 contains three reactive sites;...
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01534G, Paper
Cu(II)-catalyzed addition/oxidative cyclization of thioamides with alkynoates affords structurally important 2-aminothiophenes in moderate to excellent yields.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01548G, Paper
Synthesis and conformational analysis of β-benzotriazole N-oxide (β-BtO) substituted γ-amino acids by direct conjugate addition of HOBt to E-vinylogous γ-amino acids are reported.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01375A, Paper
This study introduces new ganglio-TPAs with enhanced efficacy for membrane protein solubilization and stabilization compared to conventional detergents.
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01743A, Paper
A facile and efficient synthesis of chromen-4-one and isoflavone frameworks has been achieved by domino C-acylation/O-acylation/aldolization sequence. This operationally simple one-pot elegant strategy provides structurally unique chromen-4-ones and isoflavones directly...
Francesca Casoni, Lucie Dupin, Gerard Vergoten, Albert Meyer, Caroline Ligeour, Thomas Gehin, Olivier Vidal, Eliane Souteyrand, Jean-Jacques Vasseur, Yann Chevolot and Francois Morvan
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01599A, Paper
A library of 24 new mannose-centered tetragalactoclusters with four different linkers (di- and triethyleneglycol with phosphodiester or phosphorothioate linkages) and six different aromatic aglycons (O-phenyl, S-phenyl, O-benzyl, S-benzyl, O-biphenyl and...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01671H, Paper
A wide variety of 10- to 29-membered oxaza-macrocycles incorporating oxindole unit were synthesized in good yield via rhodium(II) acetate dimer catalyzed intramolecular O-H/N-H insertion reactions. Interestingly, synthesis of C2-symmetric macrocycles...
Yong Yin, Xun Wu, Hong-Wei Han, Shao Sha, She-Feng Wang, Fang Qiao, Aimin Lu, Peng-Cheng Lv and Hai-Liang Zhu
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01589D, Paper
A series of novel 2-alkyl-chromeno[4,3-c]pyrazol-4(2H)-one derivatives were synthesized and evaluated their biological activities as PI3K inhibitors. In vitro biological evaluation against four human tumor cell lines revealed that most target...
Isabelle Levesque, Simon Rondeau-Gagné, Jules Romeo Neabo and Jean-Francois Morin
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01322K, Paper
Rational design of meta-linked oligophenylbutadiynylene (OPBDs) derivatives has been conducted in order to gain insights on their gelation properties and reactivity toward topochemical polymerization to yield polydiacetylenes (PDAs). Different structural...
Jorge A. Carrazana-García, Enrique M. Cabaleiro-Lago, Alba Campo-Cacharrón and Jesus Rodriguez-Otero
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01879F, Paper
The simultaneous interactions of an anion and a cation with a π system have been investigated using MP2 and M06-2X theoretical calculations. Indole was chosen as a model π system...
Andrew George Jamieson, Boris Aillard, Naomi Stephanie Robertson, Adam Baldwin and Siobhan Robins
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01832J, Paper
A series of enantiopure unnatural alkenyl amino acids required for peptide ‘stapling’ have been synthesised in good overall yields using NiII Schiff base complexes derived from a (S)-N-(2-benzoylphenyl)-1-(2-fluorobenzyl)-pyrrolidine-2-carboxamide 4 (2-FBPB)...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01614A, Paper
This is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted for publication. Accepted manuscripts are published online shortly after acceptance. This version of the article will be replaced by the fully edited, formatted and proof read Advance Article as soon as this is available.
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01274G, Paper
Nucleic acid binding molecules have been extensively explored for nucleic acid assay, nuclear imaging, and antitumor and antivirus therapies. Most of these molecules usually bear positive charges to enhance their...
Kirill Blinov, Alexei V. Buevich, Robert Thomas Williamson and Gary E Martin
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01418A, Communication
The impact of LR-HSQMBC very long-range nJCH heteronuclear shift correlation data as a supplement to HMBC data as input for the computer-assisted structure elucidation (CASE) program, Structure Elucidator®, is assessed...
Chunyong Ding, Lili Wang, Haijun Chen, Christopher Wild, Na Ye, Ye Ding, Tianzhi Wang, Mark A. White, Qiang Shen and Jia Zhou
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01040J, Paper
A mild and concise approach for the construction of a 3,4-dihydro-2H-pyran ring integrated into the A-ring of the natural product oridonin is reported herein.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00894D, Paper
Pyrrolopyridinones and pyrroloazepinones can be prepared through gold(I) or platinum(II) catalysis. These interesting gold(I) or platinum(II) catalyses are fully supported by a computational study justifying the formation of each intermediate.
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