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Organic & Biomolecular Chemistry

Rapid publication of high quality organic chemistry research
Impact Factor 3.559 48 Issues per Year Indexed in Medline
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Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01527A, Paper
Phophorylated cyclopropanes, generated via the Rh(II)-catalysed intramolecular cyclopropanation of α-(diethoxyphosphoryl)acetates, have been found to be useful precursors in the synthesis of α-alkylidene-γ-butyrolactones. These cyclopropyl intermediates undergo regioselective reductive ring-opening and...
Pierre-Michel Regenass, Stéphanie Riché, Florent Peron, Didier Rognan, Marcel Hibert, Nicolas Girard and Dominique Bonnet
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01434H, Paper
A rapid and atom economy multicomponent synthesis of complex aza-diketopiperazines (aza-DKPs) driven by Rh(I)-catalyzed hydroformylation of alkenylsemicarbazides is described. Combined with catalytic amounts of acid and the presence of nucleophilic...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01671E, Paper
A short, convergent and general strategy for stereoselective total synthesis of biologically active α-substituted γ-hydroxymethyl γ-lactone based natural products cananginone C and debilisone A has been developed. The salient features...
Kaitlin G. Henry, Lachlan Blair, Jonathan Sperry and Elizabeth Colby Davie
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01685E, Paper
The dimeric natural product montamine was originally reported as two N-feruloylserotonin (moschamine) units linked by a nitrogen-nitrogen bond, but our recent synthesis of this symmetrical diacyl hydrazide structure revealed this...
Xiong Wei, Danlin Liang, Qing Wang, Xiangbao Meng and Zhongjun Li
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01622G, Paper
Total synthesis of mangiferin, homomangiferin, and neomangiferin, three C-glycosyl xanthone natural products with a wide spectrum of pharmacological effects, have been achieved starting from 2,3,4,6-tetra-O-benzyl-glucopyranose. The key steps involve a...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01738J, Paper
A synthesis of hortonones A-C has been accomplished from Vitamin D2 via the Inhoffen-Lythgoe diol without the use of protective groups. Key steps in the syntheses include a TMS-diazomethane mediated...
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01387B, Paper
The first synthesis of α-ketoamides from phenethyl alcohol derivatives, simple and readily available substrates, was achieved.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01706A, Paper
Chemoenzymatic synthesis: Monotreme milk glycans and other sialosides containing a 4-O-acetyl-sialic acid were synthesized in a gram or preparative scales using a one-pot two-enzyme sialylation system containing bacterial CMP-sialic acid synthetase and sialyltransferase PmST3.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01475E, Review Article
Recent advance in the design of artificial metalloproteins for olefin metathesis is presented.
Qianwen Huang, Hanliang Zheng, Shuiyou Liu, Lichun Kong, Fang Luo and Gangguo Zhu
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01491G, Paper
A room temperature Pd-catalyzed azidative cycloisomerization of homoallenyl amides using TMSN3 as the azidation reagent and PhI(O2CCF3)2 as the oxidant is described, producing various 2-amino-5-azidomethylfurans in moderate to excellent yields.
Shin Miyamura, Misaho Araki, Yosuke Ota, Yukihiro Itoh, Shusuke Yasuda, Mitsuharu Masuda, Tomoyuki Taniguchi, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki, Kenichiro Itami and Junichiro Yamaguchi
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01483F, Paper
Potent and selective LSD1 inhibitors were synthesized rapidly by a C–H borylation and cross-coupling sequence.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01381C, Paper
Selective detection of amidopyrene-labeled peptides by LA-LDI MS enabled us to analyze the binding position of ligands on target proteins.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01309K, Paper
Seven novel alkylated or acylated analogues of hexahydropyridazine aza-galacto-fagomine (AGF) was prepared and studied as glycosidase inhibitors with the aim of increasing inhibitory potency and selectivity.
Sushila Sharma, Manoranjan Kumar, Shruti Sharma, Onkar S. Nayal, Neeraj Kumar, Bikram Singh and Upendra Sharma
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01362G, Paper
Vasicine and KOtBu promoted intramolecular C–H arylation has been demonstrated for synthesis of phenanthridinones and dihydrophenanthridines with various aryl halides under microwave conditions.
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01678B, Paper
The first enantioselective synthesis of the fungal metabolite (+)-O-methylasparvenone was achieved in eight steps and 22% overall yield from inexpensive 3,4,5-trimethoxybenzaldehyde dimethyl acetal. Key steps include (i) early-stage asymmetric alkynylation...
Manojkumar Janni, Sahil Arora and Saravanan Peruncheralathan
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01568A, Paper
A rapid construction of quinolone fused heterocycles from single S,N-acetal precursors via double heteroannulation is described. The base, radical and metal-mediated reactions can controll the bond formation of C—N, C—S...
Rhys Brenton Murphy, Rebecca Norman, Jonathan M White, Michael Victor Perkins and Martin Johnston
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01588C, Paper
The synthesis of a tetra-porphyrin molecular tweezer with two binding sites is described. The bis-porphyrin binding sites are aligned by a polycyclic scaffold and linked via a freely rotating phenyl...
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01645F, Communication
A highly enantioselective asymmetric addition reaction of thioglycolates and N-Boc aldimines was promoted by a bifunctional tertiary-amine squaramide catalyst.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01638C, Paper
A mild, facile, atom economical and efficient method was described for the synthesis of functionalized nonsymmetrical heteroaryl-substituted triarylmethanes via the two step Friedel–Crafts-type reaction catalyzed by FeCl3·6H2O under “open-flask” at room temperature.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01522K, Paper
Herein, an efficient [3 + 2] cycloaddition and oxidative dehydrogenation reaction of diazo compounds and alkenes was well developed using TBAI/TBHP, leading to pyrazoles with moderate to high yields.
Hassen Bel Abed, Jens Schoene, Mathias Christmann and Marc Nazaré
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01544A, Paper
An efficient strategy to access 3-amino-2H-indazoles starting from readily available 2-nitrobenzonitriles has been developed.
Caixia Xie, Lei Feng, Wanli Li, Xiaojun Ma, Xinkun Ma, Yihan Liu and Chen Ma
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01401A, Paper
An efficient and convenient one-pot domino reaction for the direct synthesis of pyrrolo[1,2-a]quinoxalines has been developed. β-Diketones and β-keto esters are well tolerated to give the corresponding products in moderate to excellent yields.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01375A, Paper
Deiodination of thyroid hormones and their decarboxylated metabolites, iodothyronamines by a series of peri-substituted selenium-containing naphthalene derivatives has been described.
Liyan Yue, Juanjuan Du, Fei Ye, Zhifeng Chen, Lianchun Li, Fulin Lian, Bidong Zhang, Yuanyuan Zhang, Hualiang Jiang, Kaixian Chen, Yuanchao Li, Bing Zhou, Naixia Zhang, Yaxi Yang and Cheng Luo
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01248E, Paper
Scaffold hopping combines with biochemical studies and medicinal chemistry optimizations, leading to potent inhibitors of the menin–MLL interaction.
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01635A, Paper
Halogen bonds are defined as interactions between halogens and a Lewis base in which the halogen (X) acts as the electrophilic species, and typically explained by the presence of a...
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65 citations
Donor–acceptor cyclopropane annulations – not just for heterocycles.
DOI: 10.1039/C4OB02117G
Published: 13 Nov 2014
38 citations
This review article covers the main types of gold(i) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.
DOI: 10.1039/C5OB00736D
Published: 19 May 2015
32 citations
The recent advances in the copper-catalysed azide–alkyne cycloaddition (CuAAC) reactions are reviewed.
DOI: 10.1039/C5OB01457C
Published: 31 Jul 2015

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