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Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

Organic synthesis, supramolecular chemistry, chemical biology and more.
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Paul Watts, Devender Mandala and Sravanthi Chada
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00480J, Paper
We report the first semi-continuous flow synthesis of lamivudine, an antiretroviral drug used in the treatment of HIV/AIDS and hepatitis B. The key intermediate (5-acetoxy oxathiolane) was prepared by an...
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00362E, Paper
This study reports on the synthesis and characterization of four molecular π-extended squaraine compounds relevant to the field of organic electronics. The compounds each consist of a bis-indole squaraine core...
Fang Miao, Zhenglong Lim, Pan Hu, Shao-qiang Dong, Qingbiao Qi, Xiaojie Zhang and Jishan Wu
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00586E, Communication
Two BODIPY-substituted anthroxyl radicals were investigated. The one with two ethyl substituents (2Et-BO-An-O) is sensitive to air and silica gel due to lack of sufficient kinetic blocking, while another one...
Lucia Barbera, Domenico Franco, Laura De Plano, Giuseppe Gattuso, Salvatore Guglielmino, Germana Lentini, Nadia Manganaro, Nino Marino, sebastiano pappalardo, Melchiorre F. Parisi, Fausto Puntoriero, ilenia pisagatti and Anna Notti
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00530J, Communication
The remarkable affinity of deca-carboxylatopillar[5]arene WP5 towards the aminoglycoside antibiotic, amikacin, in aqueous media is reported; in vitro studies on Gram-positive bacteria (Staphylococcus aureus) show that drug entrapment inside WP5...
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00486A, Communication
Fluorescent derivatives of OSW-1 and its congeners reveal that the glycosylated cholestane scaffold defines their intracellular destination to the ER and Golgi apparatus.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00333A, Paper
Vinylogous β-amino acids are constructed using a concise, enantioselective route and shown to be superior building blocks for the construction of chiral oligomers.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00637C, Communication
A facile metal-free synthesis of 2-aminonaphthalenes by intramolecular transannulation of 1-sulfonyl-4-(2-alkenylphenyl)-1,2,3-triazoles was realized with the proposed ketenimine as the key intermediate.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00402H, Communication
Heteroarene N-oxides were successfully converted to heteroarylphosphonates in a very short time under mild conditions through in situ activation with CBrCl3.
Jun-Jie Wang, Hao-Sheng Lin, Chuang Niu and Guan-Wu Wang
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00463J, Paper
The regioselective cyclopropanation of dianionic [60]fullerobenzofurans by diethyl dibromomalonate is dominantly controlled by steric factor.
Biswadip Banerji, Satadru Chatterjee, K. Chandrasekhar, Suvankar Bera, Leena Majumder, Chandraday Prodhan and Keya Chaudhuri
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00564D, Paper
We herein report the design and synthesis of a group of fused phenanthro-imidazo[1,2-a]pyridine derivatives as a new class of luminescent materials through a Pd(II) catalyzed intramolecular CDC coupling.
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00542C, Paper
A new family of protic NHC Ru complexes ligated with a phosphine-tethered imidazole moiety were prepared, which can act as excellent catalysts for acceptorless dehydrogenation of secondary alcohols and dehydrogenative...
Meirong Jia and Reuben J. Peters
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00510E, Communication
Isoprenoid precursors readily undergo (poly)cyclization in electrophilic reaction cascades, presumably as internal addition of the carbon–carbon double-bonds from neighboring isoprenyl repeats readily forms relatively stable cyclohexyl tertiary carbocation intermediates.
Chada Raji Reddy, Santosh Kumar Prajapti, Kamalkishor Warudikar, Ravi Ranjan and Billa Bhargava Rao
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00405B, Review Article
Various ipso-annulation strategies to access diversely substituted spirocyclohexadienones and their applications have been presented.
Nikolai Yu. Kuznetsov, Rabdan M. Tikhov, Ivan A. Godovikov, Michael G. Medvedev, Konstantin A. Lyssenko, Elena I. Burtseva, Elena S. Kirillova and Yuri N. Bubnov
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00331E, Communication
A series of (R)- and (S)-isomers of new adamantane-substituted heterocycles were synthesized and tested for antiviral activity.
Steve Huvelle, Ahmed Alouane, Thomas le Saux, Ludovic Jullien and Frederic Schmidt
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00121E, Paper
Kinetic analysis of disassembly of self-immolative spacers based on cyclisation processes was performed. Five compounds were synthesized belonging to two different series, and their kinetic constants were determined. Electro-donating substituents...
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00413C, Review Article
Numerous efficient synthetic methods for enantioselective indole functionalization emerged in recent years. This review summarizes major achievements in the transition-metal-catalyzed enantioselective indole functionalization reactions since 2010, which focuses on C-C...
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00293A, Paper
A ZnBr2-mediated oxidative spiro-bromocyclization of N-arylpropiolamide is described here for the synthesis of 3-Bromo-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione with a high efficiency. One equivalent of water is introduced into the final product. The reaction...
Zhen Zhang, Cheng Li, Shao-Hua Wang, Fu-Min Zhang, Xue Han, Yong-Qiang Tu and Xiao-Ming Zhang
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00620A, Paper
Herein we present a novel tandem SN2′ nucleophilic substitution/oxidative radical cyclization of aryl substituted allylic alcohols with 1,3-dicarbonyl compounds.
Arbia Talbi, Acha Arfaoui, Talia Bsaibess, Mohamed Lotfi Efrit, Anne Gaucher, Damien Prim and Hedi M'Rabet
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00206H, Paper
The selective installation of α-methylamine residues at the butenolide core is described from α-bromomethylene--butenolide and primary as well as secondary amines in methanol at 0 °C. The preparation of mono-...
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00466D, Review Article
Thiopeptide antibiotics are a class of typical ribosomally synthesized and post-translationally modified peptides (RiPPs) with complex chemical structures that are difficult to construct via chemical synthesis. To date, more than...
Ying Chen, Yong Liu, Yongchao Yao, Shiyong Zhang and Zhongwei Gu
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00169J, Paper
With special confined water pools, reverse micelles (RMs) have shown potential for a wide range of applications.
Peter Wipf, James Burnett, Chaemin Lim, Brian Daniel Peyser, Lalith P. Samankumara, Marina Kovaliov, Raffaele Colombo, Stacie Bulfer, Matt Laporte, Ann Hermone, Connor McGrath, Michelle Arkin, Rick Gussio and Donna Huryn
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00526A, Paper
The turnstile motion of two neighboring threonines sets up a dynamic side chain interplay that can accommodate both polar and apolar ligands in a small molecule allosteric protein binding site....
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00240H, Paper
A facile, green, metal-free based new one-pot synthetic strategy has been developed for the easy access to a wide array of medicinally promising functionalized pyridines having an ester, nitrile or...
Ersin Celik, Michael Maczka, Nils Bergen, Thorsten Brinkhoff, Stefan Schulz and Jeroen S. Dickschat
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00357A, Communication
The uptake and conversion of the algal sulfoquinovose catabolite 2,3-dihydroxypropane-1-sulfonate by marine bacteria was studied in isotopic labelling experiments.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00371D, Communication
Pd(t-Bu3P)2 has been successfully identified as an efficient catalyst for the hydroaminocarbonylation of aromatic alkenes to branched amides under relatively mild reaction conditions.
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29 citations
A unified strategy for the palladium-catalyzed Suzuki–Miyaura cross-coupling of amides with boronic acids for the synthesis of ketones by N–C bond activation is reported.
DOI: 10.1039/C6OB00084C
Published: 11 Feb 2016
58 citations
This review article covers the main types of gold(i) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.
DOI: 10.1039/C5OB00736D
Published: 19 May 2015
59 citations
The recent advances in the copper-catalysed azide–alkyne cycloaddition (CuAAC) reactions are reviewed.
DOI: 10.1039/C5OB01457C
Published: 31 Jul 2015

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