Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
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Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02231A, Paper
Dynamic combinatorial chemistry was used to generate a set of receptors for peptides containing methylated lysine (KMen, n = 0=3) and study the contribution of electrostatic effects and pocket depth...
Alaksiej L. Hurski, Yuri V. Ermolovich, Vladimir Nikolaevich Zhabinskii and Vladimir Aleksandrovich Khripach
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02197E, Paper
A new method for the construction of steroid side chains through the addition of lithium salts of dithianes to a C-22 aldehyde was developed. An efficient one-pot procedure for the...
Flavia Pop, Sabine Seifert, Jihane Hankache, Jie Ding, Andreas Hauser and Narcis Avarvari
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02100B, Paper
Stille and Sonogashira coupling strategies allowed the preparation of luminescent TTF-benzothiadiazole donor–acceptor compounds with direct linkage or an acetylenic spacer.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02185A, Paper
We report the synthesis of a series of anionic dendritic peptide amphiphiles of increasing hydrophobic character and describe their self-assembly into supramolecular nanorods using pH and ionic strength dependent state diagrams.
Lydia E. H. Paul, Bruno Therrien and Julien Furrer
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02194K, Paper
Interactions between three hexacationic arene ruthenium metallaprisms and human proteins have been studied using NMR spectroscopy, mass spectrometry and circular dichroism spectroscopy, showing that proteins are potential biological targets for these metallaprisms.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01958J, Paper
Carbon monoxide and molecular hydrogen are liberated from hexane-1,6-diol in a two-chamber reactor and employed for either a hydroformylation of olefins or a reductive carbonylation of aryl halides.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02017K, Paper
A copper-catalyzed method for the oxidation of allylic and benzylic sp3 C–H by aqueous tert-butyl hydroperoxide (T-Hydro) in water using a recyclable fluorous ligand has been developed.
Micke Lisbjerg, Bjarne E. Nielsen, Birgitte O. Milhøj, Stephan P. A. Sauer and Michael Pittelkow
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02211D, Communication
We show that the newly discovered 6 + 6 biotin-formaldehyde macrocycle Biotin[6]uril binds a variety of anionic guest molecules in water. We discuss how and why the anions are bound based on data obtained using NMR spectroscopy, mass spectrometry, isothermal titrations calorimetry (ITC), computational calculations and single crystal X-ray crystallography.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02238F, Paper
A versatile and efficient entry into 2-amino-pyrido[3,4-d]pyrimidines was developed. Our strategy hinges on the concise preparation and derivatisation of 8-chloro-2-(methylthio)pyrido[3,4-d]pyrimidine intermediates to yield putative kinase inhibitors.
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02036G, Communication
A highly effective 6-endo dig cyclisation of o-alkynylaldimines to 1, 2-dihydroisoquinolines has been described via direct and nitro Mannich condensation using inexpensive and readily available cobalt chloride as catalyst. This...
Fudi Zhong, Guannan Geng, Ting Pan, Bing Chen, Qianwen Li, Hui Zhang and Chuan Bai
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02247E, Paper
Human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the export of viral RNA from nucleus to cytoplasm, which is a key step in HIV-1 pathogenesis and transmission. In this...
Laura Gallego-Yerga, Michela Lomazzi, Valentina Franceschi, Francesco Sansone, Carmen Ortiz Mellet, Gaetano Donofrio, Alessandro Casnati and Jose Manuel Garcia Fernandez
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02204A, Paper
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples of monodisperse gene delivery systems. The possibility to precisely control the architectural features at the molecular...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02288B, Paper
Novel bidentate bis-(benzimidazolium) receptor containing pyrene as fluorescent signaling units has been synthesized. Fluorescent and NMR spectroscopy studies reveal that this receptor exclusively recognizes sulphate and hydrogenpyrophosphate in the competitive...
Nripendra Nath Biswas, Samuel K. Kutty, Nicolas Barraud, George M. Iskander, Renate Griffith, Scott A. Rice, Mark Willcox, David StC. Black and Naresh Kumar
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02096K, Paper
Indole based N-acylated L-homoserine lactone (AHL) mimics were developed as quorum sensing (QS) inhibitors for Gram-negative bacteria Pseudomonas aeruginosa and can be used as novel antimicrobial agents.
Ke Wang, Danzhu Wang, Kaili Ji, Weixuan Chen, Yueqin Zheng, Chaofeng Dai and Binghe Wang
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02031F, Paper
Efficient enzymatic DNA incorporation of trans-cyclooctene thymidine triphosphate (TCO-TTP) is reported. The general handle of trans-cyclooctene can undergo a rapid bioorthogonal cycloaddition with tetrazine, which is suitable for further DNA labeling work.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02248C, Paper
A generalised, simple and efficient synthesis of N-acetyl-5-bromo-4-chloroindoxyl and related analogues required for the synthesis of indigogenic substrates to probe for biological activities is reported.
Gloria Uccello-Barretta, Federica Balzano, Federica Aiello, Letizia Vanni, Mattia Mori, Sergio Menta, Andrea Calcaterra and Bruno Botta
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01936A, Paper
A rationale for the inhibition of hydrolytic efficiency of α-chymotrypsin by a resorcin[4]arene derivative was obtained by NMR spectroscopy and molecular modeling.
Thomas C. Pijper, Jort Robertus, Wesley R. Browne and Ben L. Feringa
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02120G, Paper
Rapid conversion of thio-ethers to thio-acetates using TiCl4 that tolerates a wide variety of functionalities, in good to excellent yields.
Sinem Gürbüz, Muazzam Idris and Dönüs Tuncel
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02065K, Review Article
Nanostructured materials, including nanoparticles, nanocomposites, vesicles, and rods, have been prepared by taking advantage of the interesting features of cucurbituril homologues.
Giampiero D'Adamio, Antonella Sgambato, Matilde Forcella, Silvia Caccia, Camilla Parmeggiani, Morena Casartelli, Paolo Parenti, Davide Bini, Laura Cipolla, Paola Fusi and Francesca Cardona
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02016B, Paper
(–)-Uniflorine A and 7-deoxy-uniflorine A are selective inhibitors of insect trehalases from C. riparius and S. littoralis.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02058H, Paper
Caffeic acid and α-tocopherol (vitamin E) incorporate spontaneously into the interfacial regions of emulsions and their transfer processes are entropy driven.
S. M. Forget, A. Jee, D. A. Smithen, R. Jagdhane, S. Anjum, S. A. Beaton, D. R. J. Palmer, R. T. Syvitski and D. L. Jakeman
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02057J, Paper
We have developed a continuous spectrophotometric kinetic assay for the detection of PPi and have applied the assay to evaluate Cps2L, a nucleotidylyltransferase, kinetics with five synthetic substrate analogues (2–6).
Yao-Feng Wang, Jiashen Qiu, Dejie Kong, Yongtao Gao, Feipeng Lu, Pran Gopal Karmaker and Fu-Xue Chen
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02032D, Communication
Electrophilic cyanating agent C1 accomplishes the direct cyanation of β-keto esters and amides without any catalyst and base.
Richard G. Doveston, Paolo Tosatti, Mark Dow, Daniel J. Foley, Ho Yin Li, Amanda J. Campbell, David House, Ian Churcher, Stephen P. Marsden and Adam Nelson
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02287D, Paper
Sourcing large numbers of lead-like compounds is a major challenge; a unified synthetic approach enabled the efficient synthesis of 52 diverse lead-like molecular scaffolds from just 13 precursors.
Haifan Wu, Fengyu She, Wen-Yang Gao, Austin Prince, Yaqiong Li, Lulu Wei, Allison Mercer, Lukasz Wojtas, Shengqian Ma and Jianfeng cai
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02232G, Communication
We report an efficient method for the preparation of unprecedented head-to-tail cyclic sulfono-γ-AApeptides. Following this method, a number of cyclic sequences bearing two to five subunits were efficiently synthesized. In...
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