Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
 
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Shiue-Shien Weng, Wen-Chieh Yang, Ananthan Ramasamy, Gobi Rajeshwaren, Yi-Ya Liao and Chien-Tien Chen
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02621G, Paper
A series of oxometallic species and metal acetylacetonates (acac) was examined as catalysts for oxidative carbonylation of styrene with benzaldehyde by using t-butylhydroperoxide as co-oxidant in warm acetonitrile. Among them,...
 
Weitao Gong, Duo Na, Le Fang, Hassan Mehdi and Guiling Ning
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02498B, Communication
Gemini surfactant-like receptor R1 is designed and synthesized. The special preassembly phenomenon of R1 in nonpolar solvent facilitate the novel ratiometric fluorescence sensing of H2PO4- via anion-induced reassembly process in...
 
Xiang Li, Suyan Sun, Fan Yang, Jianxun Kang, Yusheng Wu and Yangjie Wu
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02410A, Paper
An efficient and general applicable protocol for palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with dialkyl H-phosphonates has been developed. This methodology provides a new and practical route to alkynylphosphonates using...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02212B, Paper
The ability to specifically engineer metal binding sites into target proteins has far-reaching consequences ranging from the development of new biocatalysts and imaging reagents to the production of proteins with...
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02535K, Paper
A regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an enzyme-responsive functionality, depending on the protease activity was constructed.
 
Qi Yan, Brigitte F. Schmidt, Lydia A. Perkins, Matharishwan Naganbabu, Saumya Saurabh, Susan K. Andreko and Marcel P. Bruchez
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02309A, Paper
A bis-sulfonate linker modified malachite green fluorogen improves its specificity and allows rapid, no-wash labeling of receptors on living cells.
 
Matthias Winkler, Marjorie Maynadier, Sharon Wein, Marie-Ange Lespinasse, Giovanna Boumis, Adriana E. Miele, Henri Vial and Yung-Sing Wong
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02459A, Paper
An expedient synthesis of aculeatin-like analogues results in finding PfTrxR as putative cellular target and a promising new antimalarial chemotype.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02343A, Paper
An efficient and regioselective copper(II)-catalyzed coupling reaction of N′-aryl acylhydrazines for the synthesis of N′,N′-diaryl acylhydrazines has been developed.
 
Mariëlle M. E. Delville, Kaspar Koch, Jan C. M. van Hest and Floris P. J. T. Rutjes
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02128B, Communication
From themed collection Recent Advances in Flow Synthesis and Continuous Processing
Integrated two-step chemoenzymatic continuous flow process for the synthesis of protected cyanohydrins from aldehydes.
 
Marc Y. Stevens, Krzysztof Wieckowski, Peng Wu, Rajiv T. Sawant and Luke R. Odell
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02417F, Paper
A series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a novel cascade imine/cyclization/aza-Henry reaction in moderate to excellent yields.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02340D, Paper
The elimination of HCl and CO2 in the corresponding cycloadducts makes the unfavourable polar Diels–Alder reaction of 3-chloroindole irreversible.
 
Artur J. Moro, Bertrand Rome, Elisabet Aguiló, Julià Arcau, Rakesh Puttreddy, Kari Rissanen, João Carlos Lima and Laura Rodríguez
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02077D, Paper
A phosphine-gold(I)-alkynyl-coumarin complex, [Au{7-(prop-2-ine-1-yloxy)-1-benzopyran-2-one}(DAPTA)] (1), was synthesized and the formation of long luminescent fibers in solution was characterized via fluorescence microscopy and dynamic light scattering.
 
Gowri Priya, Amol S. Kotmale, Debamitra Chakravarty, Vedavati G. Puranik, Pattuparambil R. Rajamohanan and Gangadhar J. Sanjayan
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02421D, Paper
This communication describes the utility of the conformationally restricted aromatic β-amino acid (2-aminobenzenesulfonic acid, SAnt) for inducing various folding interactions in short peptides.
 
Mathias Pichler, Johanna Novacek, Raphaël Robiette, Vanessa Poscher, Markus Himmelsbach, Uwe Monkowius, Norbert Müller and Mario Waser
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02318H, Paper
Phenylglycinol serves as a powerful chiral auxiliary in ammonium ylide-mediated reactions to obtain chiral epoxides/aziridines with excellent stereoselectivities.
 
Juan Francisco Moya-López, Eleonora Elhalem, Rocío Recio, Eleuterio Álvarez, Inmaculada Fernández and Noureddine Khiar
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02030H, Paper
The exo-anomeric effect paves the way for the synthesis of the usually less favored RS-β-sulfinyl glycoside as a single diastereoisomer.
 
Jenifer Rubio-Magnieto, Florent Di Meo, Mamadou Lo, Cécile Delcourt, Sebastien Clement, Patrick Norman, Sebastien Richeter, Mathieu Linares and Mathieu Surin
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02097A, Paper
The molecular recognition of Human telomeric G-quadruplexes by a novel cationic π-extended NiII-porphyrin (NiII-TImidP4, Chart 1) is studied in aqueous solutions via (chir)optical spectroscopy, Fluorescence Resonance Energy Transfer (FRET) melting...
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02358G, Paper
A phenol-catalyzed aerobic oxidative styryl ether formation method was developed with benzyl alcohol under basic DMSO.
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02444C, Paper
Activity-based probes (ABPs) are powerful tools for the analysis of active enzyme species in whole proteomes, cells or animals. Quenched fluorescent ABPs (qABPs) can be applied for real time imaging,...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02328E, Paper
Acyclic (L)-threoninol nucleic acid (aTNA) containing thymine, cytosine and adenine nucleobases were synthesized and shown to form surprisingly stable triplexes with complementary single stranded homopurine DNA or RNA targets. The...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02470B, Paper
Different strategies are employed in designing strong and selective anion receptors but stereoelectronic effects have been largely ignored. In this work, the stereo configuration of a non-interacting ether is found...
 
David McCutcheon, William Porterfield and Jennifer Prescher
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02529F, Paper
Bioluminescence imaging with luciferase-luciferin pairs is a popular method for visualizing biological processes in vivo. Unfortunately, most luciferins are difficult to access and remain prohibitively expensive for some imaging applications....
 
Su-Ying Xu, Xiaolong Sun, Haobo Ge, Rory L. Arrowsmith, John S. Fossey, Sofia I. Pascu, Yun-Bao Jiang and Tony D. James
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02267J, Communication
A biocompatible fluoride receptor has been developed where the interaction between the boronic acid ester and amine (NH) results in fluoride ion selectivity and enhanced fluorescence quenching.
 
Samuel Furse, LokHang Mak, Edward W. Tate, Richard H. Templer, Oscar Ces, Rüdiger Woscholski and Piers R. J. Gaffney
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02258K, Paper
Single enantiomers of PI-4-P, with a range of sn-2-fatty acid esters, were prepared efficiently. The effects of the degree of sn-2-unsaturation on the kinetic parameters of SopB were determined.
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02466D, Paper
Sulfur dioxide (SO2) is a gaseous environmental pollutant which is routinely used in industry as a preservative and antimicrobial. Recent data suggests that SO2 may have value as a therapeutic...
 
Daniele Castagnolo, Leonardo Degennaro, RENZO LUISI and Jonathan Clayden
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02329C, Paper
The addition of n-butyllithium to alkenylthiocarbamates in the presence of (–)-sparteine or the (+)-sparteine surrogate leads to asymmetric carbolithiation, and returns enantiomerically enriched thiocarbamate derivatives of secondary thiols. In THF,...
 
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