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Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in Medline
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Miu Shan Chan, Di Xu, Lei Guo, Dick Yan Tam, Ling Sum Liu, Man Shing Wong and Pik Kwan Lo
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00643K, Paper
We report the first example of a novel two-photon active, biocompatible, and macrophage cell-membrane permeable carbazole-based cyanine fluorophore for detection of three biologically important ROS namely, .OH, O2− and OCl−...
Vanessa Kar-Yan Lo, Anna On-Yee Chan and Chi-Ming Che
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00407A, Review Article
A summary of gold (including AuNPs, Au(I) and Au(III) complexes) and silver(I) catalysis and their application in bioconjugation reactions.
Yogesh Siddaraju and Kandikere Ramaiah Prabhu
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00684H, Paper
A novel method for α-hydroxylation of ketones using substoichiometric amount of iodine under metal-free conditions is described.
Leandro de C. Alves, André L. Desiderá, Kleber T. de Oliveira, Sean Newton, Steven V. Ley and Timothy J. Brocksom
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00525F, Paper
A route to enantiopure (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1, an intermediate for terpenoids, has been developed and includes a highly chemo- and regioselective Tiffeneau–Demjanov reaction.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00500K, Paper
A theranostic prodrug for mechlorethamine has been developed for photo-controlled release and monitoring by fluorescence spectroscopy.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00283D, Communication
Adding 2-hydroxyisobutyryl lysine to the genetic code of E. coli is reported.
Antonella Virgilio, Veronica Esposito, Luciano Mayol, Concetta Giancola, Luigi Petraccone and Aldo Galeone
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00748H, Paper
The effects of 5-hydroxymethyl-2′-deoxyuridine on two human telomeric G-quadruplexes have been investigated. Reported results suggest a possible protecting effect of the loop residues on the other parts of the structure.
Sebastian Reimann, Silvio Parpart, Peter Ehlers, Muhammad Sharif, Anke Spannenberg and Peter Langer
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00866B, Paper
Chemoselective Suzuki-Miyaura reactions on 3,5-dibromo-2,6-dichloropyridine were studied. The optimized reaction conditions allow for the facile access of 3-aryl- and 3,5-diarylpyridines in good yields. Suzuki-Miyaura reactions of the selectively synthesized 2,6-dichloro-3,5-diarylpyridines...
xin zhou, xue wu, juan xiao, chunmei jin, Zhixue Liu, Shujing Guo and xiaochuan zhang
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00710K, Paper
1-benzyl-3-(substituted aryl)-5-methylfuro[3, 2-c]pyrazoles (YC-1) is a well-known synthetic compound with various satisfactory pharmacological activities, such as the activation of soluble gualylate cyclase (sGC) and the inhibition of hypoxia-induced factor-1 (HIF-1)....
Yao Huang, Tieqiao Chen, Qiang Li, Yongbo Zhou and S.-F. Yin
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00685F, Paper
An efficient copper catalyzed direct aerobic oxidative amidation of methyl groups of azaarylmethanes with N-H bonds producing amides is successfully developed, which can produce primary, secondary and tertiary amides, including...
Margaret A Brimble, Luis M De Leon Rodriguez and Andreas Weidkamp
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00880H, Perspective
Cyclotetrapeptides are important bioactive lead drug molecules that display a wide spectrum of pharmacological activities. However, the synthesis of cyclotetrapeptides from their linear precursors is challenging due to the highly...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00852B, Paper
The total synthesis of a number of carbazolo-1,4-quinone natural products using on-water chemistry is described. A recently developed domino ‘in-water, on-water’ process is employed to rapidly and efficiently generate königinequinone...
Guo-Jun Deng, Hao Xie, Yunfeng Liao, Shuqing Chen and Ya Chen
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00915D, Communication
A novel Cu-catalyzed direct amidation of 2-methylquinolines with amines is described. This method afforded an effieient approach for the synthesis of biologically important aromatic amides from readily available coupling partners...
Joan C Ferrer, Mireia Díaz-Lobo, Jaume Garcia-Amorós, Ignacio Fita, Dolores Velasco and Joan J Guinovart
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00796H, Paper
Glycogen is a polymer of α-1,4- and α-1,6-linked glucose units that provides a readily available source of energy in living organisms. Glycogen synthase (GS) and glycogen phosphorylase (GP) are the...
Xiaoyan Pan, Jinyun Dong, Yaling Shi, Ruili Shao, Fen Wei, Jinfeng Wang and Jie Zhang
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00430F, Paper
Forty-two compounds (series 8, 9 and 10) incorporated with diacylated piperazine have been synthesized and characterized as novel Bcr-Abl inhibitors based on 'six-atom linker'. Five compounds 8d, 8h, 8l, 10m...
B. V. Subba Reddy, B. Someswarao, N. Prudhviraju, B. Jagan Mohan Reddy, B. Sridhar and S. Kiran Kumar
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00518C, Paper
A domino cyclization of 4-(2-hydroxyethyl)cyclohex-3-enol with aldehydes using 10 mol% molecular iodine is reported to produce oxygen bridged bicyclic ethers in good yields with high selectivity.
Marcel Albrecht, Andreas Lippach, Matthias P. Exner, Jihene Jerbi, Michael Springborg, Nediljko Budisa and Gerhard Wenz
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00505A, Paper
We report a straightforward synthesis of 8-ethynyl-BODIPY derivatives and their potential as fluorescent labeling compounds using an alkyne–azide click chemistry approach.
Lucia Barbera, Giuseppe Gattuso, Franz H. Kohnke, Anna Notti, Sebastiano Pappalardo, Melchiorre F. Parisi, Ilenia Pisagatti, Salvatore Patanè, Norberto Micali and Valentina Villari
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00703H, Communication
The ability of an anionic calix[4]arene amphiphile to aggregate and to solubilize, as a result, the poorly water-soluble drugs naproxen and flurbiprofen is described.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00601E, Communication
A ruthenium-catalyzed oxidative coupling of 2-aryl-quinazolinones with olefins via C–H bond activation followed by an intramolecular aza-Michael reaction is described.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00809C, Communication
Synthesis and characterization of some new [15]-macrodilactones revealed that the interplay between three planar units, a stereogenic center and a hinge atom generated a planar chirality that governs their molecular topology.
Dawei Hu, Namiki Miyagi, Yuki Arai, Hiroaki Oguri, Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Hiroaki Gouda, Ossama El-Kabbani, Shuang Xia, Naoki Toyooka, Akira Hara, Toshiyuki Matsunaga, Akira Ikari and Satoshi Endo
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00847F, Paper
Human carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/reductase superfamily, reduces anthracycline anticancer drugs to their less potent anticancer C-13 hydroxy metabolites, which are linked with pathogenesis of...
Faviola Cardoso-Martínez, José M. de la Rosa, Ana R. Díaz-Marrero, José Darias, Claudia Cerella, M Diederich and Mercedes Cueto
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00773A, Paper
Tanzawaic acids M (1), N (2), O (3) and P (4) and the known tanzawaic acids B (5) and E (6), have been isolated from an extract of a cultured...
Hyun-Joon Ha, Jae-Hoon Jung, Doo-Ha Yoon, Hyeonah Shin, Kyuwoong Lee, Won Koo Lee and Cheol-min Yook
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00375J, Paper
Chiral aziridine was utilized for the synthesis of anti-bacterial natural amino acid L-(+)-furanomycin, and its analogues including 5′-epi-furanomycin and norfuranomycin. Key steps of this synthesis are the stereoselective Pd-catalyzed etherification...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00917K, Communication
We report herein a highly exo-selective intramolecular Diels-Alder reaction of alkenyl boronates which employs an N-B dative bond-involved bicyclic rigid tether. Complex C(sp3)-rich polycyclic molecules containing up to 8 stereocenters...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00377F, Paper
Driven by the shortage of known effective possibilities for the synthesis of 4-hydroxy-3,4-dihydro-2H-1,3-thiazine-2-thiones on the one hand and the promising potential of these structures as novel drug candidates on the...
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