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Organic & Biomolecular Chemistry

Rapid publication of high quality organic chemistry research
Impact Factor 3.562 48 Issues per Year Indexed in Medline
 
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Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00756B, Communication
A trifluoroacetic acid catalyzed highly 6-endo regioselective bromocyclization of styrene-type carboxylic acid has been developed.
 
Robert A. Coover, Nicole M. Luzi, Sudha Korwar, Maria E. Casile, Charles E. Lyons, Darrell L. Peterson and Keith C. Ellis
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00529B, Communication
A new fluorescent-labeled inhibitor for PKACα was developed that potently inhibits the kinase (IC50 = 11.8 nM), is >100-fold selective for PKACα, and irreversibly labels Cys199.
 
Shyam K Konda, Celine Kelso, Paul Pumuye, Jelena Medan, Brad E. Sleebs, Suzanne M Cutts, Don R Phillips and John Grant Collins
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00561F, Paper
The ability of the anthracenedione anticancer drug WEHI-150 to form covalent adducts with DNA, after activation by formaldehyde, has been studied by electrospray ionisation mass spectrometry and HPLC. Mass spectrometry...
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00431H, Paper
A practical three-step protocol for the synthesis of pyrazino[1,2-b]isoquinolines is reported. The approach included a one-pot parallel cyclization/elimination process followed by a 6-endo Heck cyclization that transformed previously constructed Ugi...
 
Rachel K Chambers, Tanweer A Khan, David Olsen and Brad E. Sleebs
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C5OB01842K, Review Article
Aspartyl proteases are important pharmacological targets. Historically aspartyl proteases have been commonly targeted with transition state derived peptidomimetics. The strategy to develop aspartyl protease inhibitors has undertaken a dramatic paradigm...
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00901H, Paper
Synthesis of isoquinolines based on efficient C-C and C-N bond formation through Rh (III)-Catalyzed C-H activation and subsequent intramolecular cyclization is reported. Diazodiesters serving as a C2 source in the...
 
Anna Di Fiore, Giuseppina De Simone, Vincenzo Alterio, Vincenzo Riccio, Jean-Yves Winum, Fabrizio Carta and Claudiu Supuran
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00803H, Paper
JNJ-26990990 ((benzo[b]thien-3-yl)methyl)sulfamide, a sulfamide derivative structurally related to the antiepileptic drug zonisamide, was reported to be devoid of carbonic anhydrase (CA, EC 4.2.1.1) inhibitory properties. Here we report that JNJ-26990990...
 
Kangjiang Liang, Ting Wu and Chengfeng Xia
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00682E, Paper
A concise total synthesis of (±)-serotobenine via a strategy inspired by the biosynthetic hypothesis for this alkaloid was accomplished.
 
Juan Xiong, Zhi-Lai Hong, Peng Xu, Yike Zou, Shang-Bo Yu, Guo-Xun Yang and Jin-Feng Hu
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00731G, Paper
Twelve new ent-abietane diterpenoids including four unprecedented structures were isolated and characterized from the rare plant Chloranthus oldhamii.
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00685J, Paper
The development of new methods for the preparation of functionalized, optically enriched piperidines is important in the field of drug discovery where this class of heterocycles is often deemed a...
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00716C, Paper
We evaluate the ability of hexahistidine (His6) tags on peptide and protein substrates to recruit deoxyribozymes for modifying those substrates. For two different deoxyribozymes, one that creates tyrosine-RNA nucleopeptides and...
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00648E, Paper
α-Chloroalkanesulfonylhydrazines were synthesized directly and efficiently from various alkanesulfonyl chlorides and dialkyl azodicarboxylates under the catalysis of tertiary amines. Tertiary amines serve as both bases and nucleophiles. They dehydrochlorinates from...
 
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00438E, Paper
Herein we describe a catalyst-free, one-pot procedure employing a tandem Ugi-4CR—thermal Huisgen cycloaddition to generate a set of turn-forming amino-benzotriazoloazocinone-bearing dipeptide analogs.
 
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00314A, Paper
The DARinv on resin is a new orthogonal reaction in peptide synthesis and the benefits for cell adhesion are discussed.
 
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00469E, Communication
A facile and practical method for the preparation of 6H-indolo[2,3-b]quinolines and neocryptolepines was developed under the promotion of ferric trichloride.
 
Aniruddha Dey, Soumitra Agasti and Debabrata Maiti
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00395H, Review Article
From themed collection Current Hot Articles in Organic & Biomolecular Chemistry
The directing group assisted site selective C–H functionalization approach is having a continuous impact in the field of natural product synthesis, drug discovery and material sciences.
 
Victoria K. Kensy, Gregory I. Peterson, Derek C. Church, Neal A. Yakelis and AJ Boydston
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00400H, Communication
From themed collection New Talent
We have investigated the reversible hetero-Diels-Alder reaction of 1,2-oxazines derived from a peralkylcyclopentadiene and a series of nitrosocarbonyl dienophiles. The nature of the dienophile was found to impart broad tunability...
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00676K, Paper
An efficient synthesis of imides has been developed through a Pd-catalyzed decarboxylative amidation of α-oxocarboxylic acids with secondary amides. The reactions of N-substituted N-heteroarene-2-carboxamides with 2-oxo-2-arylacetic acids underwent smoothly to...
 
Lenka Kubovicova, Kristýna Bürglová and Jan Hlavac
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00737F, Paper
An efficient method for removal of hydrazine group from (hetero)aromatic substrates has been developed. It can be realized both on solid support and in solution by synthesis employing low concentrated...
 
Akira Yoshimura, Mekhman S. Yusubov and Viktor V Zhdankin
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00773B, Review Article
Hypervalent iodine compounds have found wide practical application as versatile, efficient, and sustainable reagents for organic synthesis. Pseudocyclic hypervalent iodine derivatives are characterized by the presence of additional intramolecular non-covalent...
 
Rajdip Karmakar, Kung-Pern Wang, Sang Young Yun, Phani Mamidipalli and Daesung Lee
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00524A, Communication
A new functionalization method of arynes promoted by a novel catalytic role of the Grubbs-type ruthenium alkylidene complex is described. Through a sequence of aryne formation followed by their halo-functionalization,...
 
Margaret A Brimble, Renata Kowalczyk, Lauren Yule, Deborah L Hay, Rebekah Bower and Harveen Kaur
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00850J, Paper
Pramlintide (Symlin®), a synthetic analogue of the neuroendocrine hormone amylin, is devoid of the tendency to form cytotoxic amyloid fibrils and is currently used in patients with type I and...
 
Josipa Suć, Lidija-Marija Tumir, Ljubica Glavas-Obrovac, Marijana Jukić, Ivo Piantanida and Ivanka Jeri?
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00425C, Paper
Series of novel hydrazino-based peptidomimetics and analogues comprising N-terminal lysine and C-terminal phenanthridinyl-L-alanine were prepared. Presented results demonstrate up till now unknown possibility to finely modulate peptide interaction with DNA/RNA...
 
Ming Zhou, Zejian Xue, Min Cao, Xiu-Qin Dong and Xumu Zhang
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00540C, Communication
We have first successfully developed a strategy for the enantioselective Rh-TaniaPhos catalyzed asymmetric hydrogenation of unprotected β-enamine phosphonates to access free β-amino phosphonates directly with good enantioselectivities (80%-86% ee) and...
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00674D, Communication
Palladium-catalyzed C–H alkylation reaction with alkylboronic acids has successfully been developed using removable pyridyldiisopropylsilyl directing group. The amino acid played a crucial role as a ligand in the reaction. The...
 
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