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Organic & Biomolecular Chemistry

Rapid publication of organic chemistry research
Impact Factor 3.562 48 Issues per Year Indexed in Medline
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Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01534K, Communication
The Bu4NI-catalyzed α-oxyacylation of diarylethanones with acyl peroxides is developed. The reaction is conducted at room temperature without metal catalysts and tolerates a series of functional groups leading to α-oxyacylated...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01006C, Paper
This paper focuses on an interesting constitutional isomerism called azido-tetrazole equilibrium which is observed in azido-substituted N-heterocycles. We present a systematic investigation of substituent effects on the isomer ratio within...
Anusha Sebastian, Ameya Sinha, Pokunoth C Baburajeev, Trang TT Chu, Jessin Mathai, Kanchugarakoppal S Rangappa, Salundi Basappa, Rajesh C Das, julian e fuchs, Andreas Bender, Huang Ximei, Peter Rainer Preiser and Shivananju NanjundaSwamy
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01479D, Paper
Malaria parasites currently gain resistance rapidly, across countries and continents. Hence, the discovery and development of novel chemical compounds, as well as scaffolds, with superior antimalarial activity remains an important...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01587A, Paper
A convenient procedure for the synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzontriles has been developed. By using KOtBu as the promotor and with 2-aminopyridines or amidines as the reaction partner,...
Shanshan Chen, Xihao Chang, Yu Tao, Yong Xia and Minghao Chen
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00432B, Paper
A Palladium(II)-catalyzed direct alkenylation reaction of dihydropyranones was developed. Various substituted dihydropyranones could afford the desired products in reasonable yields. And different acrylates were found to be good coupling partners...
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01624J, Paper
We herein report a novel class of dual enzyme-responsive fluorogenic probes based on two orthogonal deprotection reactions via the “covalent assembly” principle. Sensing of two different enzymes (hydrolase and nitroreductase) through domino reactions, producing the push–pull backbone of a fluorescent 3-substituted 7-hydroxy-2-iminocoumarin dye, is reported.
Charles Beromeo Bheeter, Abhishek Dutta Chowdhury, Rosa Adam, Ralf Jackstell and Matthias Beller
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01722J, Paper
A new catalyst for efficient C–H borylation reactions of (hetero)arenes in the presence of light is described. Various borylated arenes and heteroarenes are obtained in good yield using trans-[Rh(PMe3)2(CO)Cl] as an active photocatalyst and HBPin as an economic boron source under mild conditions.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01471A, Paper
The fluorination of α- and β-C-linked-galactosyl ethanals using NFSI and Jørgensen catalyst, followed by reduction or methylenation of the derived aldehydes provided versatile precursors to flluorinated glycomimetics. The (R) and (S) catalysts gave stereochemically complementary results.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01431J, Paper
An effective palladium-catalyzed enantioselective hydroesterification of alkenylphenols with phenyl formate as a CO source is described.
Ye Huang, Miao Tian, Yichao Zhang, Gang Sheng, Zhuo Chen, Yuan Ma, Yue Chen, Yihong Peng, Yi-Lei Zhao, Yanli Wang, Lihe Zhang and Zhenjun Yang
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01119A, Paper
Isonucleotide modification around the cleavage site of the passenger strand affects the in vitro potency of modified siRNAs by altering the motion pattern of the Ago2-PAZ domain.
Ravi Prakash Singh, V. U. Bhaskara Rao and Krishna Kumar
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01560J, Communication
Cesium fluoride catalyzed direct cyanomethylation of various isatins by using trimethylsilyl acetonitrile (TMSAN) as a nucleophile has been developed. The reaction has been explored for a number of isatins, with...
Hirokuni Shionari, Yusuke Inagaki, Kentaro Yamaguchi and Wataru Setaka
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01644D, Paper
Pyrene is a common organic luminescent material. To improve the fluorescence properties of pyrene, we have designed a pyrene-2,7-diyl bridged macrocage in which the pyrene moiety is sterically protected by...
Akihiro Kasai, Shinsuke Arafuka, Nozomi Koshiba, Daisuke Takahashi and Kazunobu Toshima
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01634G, Paper
Low-molecular weight type I and II fucoidan derivatives with different sulfation patterns were designed and systematically synthesized from the corresponding common key intermediate and their anti-proliferative activities and apoptosis-inducing activities...
Simon Jones, Harry Adams, Anthony J. H. M. Meijer, Francois-Moana Gautier and Ramadan Ali Bawa
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01343G, Paper
Several 9-(2-aminoethyl)anthracene derivatives were prepared with different nitrogen substitutents including alkyl, acetamide, trifluoroacaeamide and t-butyl carbamate. The selectivity in Diels_alder cyclodaddition reaction with N-methyl maleimide was evaluated thorugh single crystal...
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01351H, Paper
New pentaerythritol tetrabromide based chiral quaternary ammonium salts have been prepared and used as organocatalysts for enantioselective Michael addition reactions between various nitroolefins and Michael donors under mild reaction conditions with very good chemical yields and ee's.
Franziska Kohl, Janina Schmitz, Norbert Furtmann, Anna-Christina Schulz-Fincke, Matthias D. Mertens, Jim Küppers, Marcel Benkhoff, Edda Tobiasch, Ulrike Bartz, Jürgen Bajorath, Marit Stirnberg and Michael Gütschow
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01613D, Paper
Cysteine cathepsin inhibition and cellular uptake of a coumarin 343-containing dipeptide nitrile was analyzed.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01582K, Paper
This work is the first example reporting the gas-phase benzyl anion transfer to conduct the intramolecular SNAr reactions.
Camilo F. Martinez-Farina, Nicole McCormick, Andrew W. Robertson, Helen Clement, Alison Jee, Anna Ampaw, Nei-Li Chan, Ray T. Syvitski and David L. Jakeman
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01508A, Paper
First evidence that jadomycins bind human topoisomerase IIβ.
Jinwei Sun, Fuyao Wang, Yongmiao Shen, Huizhen Zhi, Hui Wu and Yun Liu
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01359C, Paper
A direct and highly regioselective C1-acyloxylation of indolizines was developed via palladium-catalyzed C–H functionalization. In this reaction, the regioselectivity was achieved in the absence of a directing group.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01702E, Paper
Superoxide dismutase (SOD) is a 32 kDa dimeric enzyme that actively removes a toxic oxygen species within red cells.
Yi-Min Liu, Hsueh-Yun Lee, Mei-Jung Lai, Shiow-Lin Pan, Hsiang-Ling Huang, Fei-Chiao Kuo, Mei-Chuan Chen and Jing-Ping Liou
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01509J, Paper
We synthesized a series of pyrimidinedione derivatives and evaluated their activities.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01408E, Paper
Aldehydes undergo a smooth coupling with (E/Z)-non-3-en-8-yn-1-ol in the presence of 10 mol% of CuX and BF3·OEt2 under mild conditions to produce a novel class of octahydrocyclohepta[c]pyran-6(1H)-one derivatives in good yields with excellent diastereoselectivity.
Mohit Kumar, Madugula Drona Reddy, Ananya Mishra and George J. Subi
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01448D, Communication
Perylenebisimide functionalized with phosphate recognition unit assembles into left-handed, right-handed or racemic helical assembly on binding with AMP, ATP and inorganic phosphates, respectively. Thus, competitive binding among these multivalent guests...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01465D, Paper
A directing-group-assisted copper-catalyzed oxidative esterification of phenols with aldehydes using TBHP as oxidant was described. This methodology which showed the advantages of base, ligand free, short routes and functional group...
Sunil Hamal, Thomas D'huys, William F. Rowley, Kurt Vermeire, Stefano Aquaro, Brian J Frost, Dominique Schols and Thomas Wayne Bell
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01557J, Paper
The chemokine receptor CXCR4 acts as a key cell surface receptor in HIV infections, multiple forms of cancer, and various other pathologies, such as rheumatoid arthritis and asthma. Macrocyclic polyamines...
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