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Organic & Biomolecular Chemistry

Rapid publication of high quality organic chemistry research
Impact Factor 3.559 48 Issues per Year Indexed in Medline
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Iris Pflueger, Coralie Charrat, Carmen Ortiz Mellet, Jose Manuel Garcia Fernandez, Christophe Di Giorgio and Juan Manuel Benito
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01882C, Paper
Exhaustive structure-efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined or polydisperse nature of the formulations. Facial amphiphiles based on rigid cage-type molecular scaffolds offer...
Nataliya Sergeevna Goulioukina, Nikolai Nikolaevich Makukhin, Egor Dmitrievich Shinkarev, Y K. Grishin, Vitaliy A. Roznyatovsky and Irina P Beletskaya
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01780K, Paper
5-Aryl-substituted pyrazol-3-ylphosphonates have been conveniently synthesized by 1,3-dipolar cycloaddition of 1-formamidovinylphosphonate and aryldiazomethanes under K2CO3/MeOH conditions at room temperature. These pyrazoles are formed in one pot via spontaneous elimination of...
Kaivalya Kulkarni, Boris Miokovic, Matthew Sauder and Graham Murphy
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02074G, Paper
An operationally simple conversion of aromatic aldehyde hydrazones to monofluoromethylated arenes is reported. The hypervalent iodine reagent TolIF2 serves as an oxidant, converting hydrazone derivatives of aromatic aldehydes to the...
Maria Kopsida, Gemma A. Barron, Giovanna Bermano, Paul Kong Thoo Lin and Marie Goua
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01850E, Paper
Chemical and biological properties of novel bisnaphthalimidopropyl derivatives.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01702A, Paper
Diverse pyrenyl–pyrenyl pairs in 10–23 DNAzyme complexes were used to explore the folding of the catalytic core in solution.
Daniele Ragno, Anna Zaghi, Graziano Di Carmine, Pier Paolo Giovannini, Olga Bortolini, Marco Fogagnolo, Alessandra Molinari, Alessandro Venturini and Alessandro Massi
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01868H, Paper
The KOtBu-DMF system promotes benzoin- and Stetter-like reactions of alpha-diketone donors through a double electron-transfer-based mechanism.
Alejandro Torres, Pilar Gutierrez, Ramón Alvarez-Manzaneda, Rachid Chahboun and Enrique Alvarez-Manzaneda
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01640E, Paper
The first syntheses of cytotoxic marine arenarans A and B starting from commercial (−)-sclareol are reported. The oxocene ring of the target compound is formed via ring-closing metathesis. This synthetic strategy is also applicable to the synthesis of other oxocene terpenes.
Mingxing Qian, Elizabeth B. Engler-Chiurazzi, Sara E. Lewis, Nigam P. Rath, James W. Simpkins and Douglas F. Covey
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01726F, Paper
Estrone and 17β-estradiol are phenolic steroids that are known to be neuroprotective in multiple models of neuronal injury.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB02012G, Paper
A copper-catalyzed oxidative cyclization of vinyl azides with benzylic Csp3–H bonds via a tandem dual C–H functionalization process has been developed. This reaction allows access to substituted phenanthridines containing a variety of functional groups.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01899H, Communication
A novel cyclic N-phosphoryl ketimine structure can efficiently react with olefins as useful directing groups to construct a myriad of phosphate scaffolds via rhodium(III)-catalyzed ortho-alkenylation.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01794K, Paper
The one-pot reactions include sequential base-mediated treatment of amidoxime with an aldehyde to form 4,5-dihydro-1,2,4-oxadiazole, and oxidization of the 4,5-dihydro-1,2,4-oxadiazole by another aldehyde to afford 1,2,4-oxadiazole.
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01960A, Communication
Three 2ʹ-C,4ʹ-C-ethyleneoxy-bridged 2ʹ-deoxyribonucleic acids possessing six-membered bridge with 6ʹ-oxygen and 8ʹ-exocyclic methylene groups (methylene-EoDNAs) were designed and synthesized in nine steps from 5-methyluridine. The methylene-EoDNA-modified oligonucleotides showed excellent binding affinity...
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01758D, Paper
A silver(I)-catalyzed Smiles rearrangement of 2-aryloxy- or 2-(arylthio)benzoic acids to provide aryl-2-hydroxybenzoate or aryl-2-mercaptobenzoate dimer, respectively, through 1,5-aryl migration from oxygen or sulfur to carboxylate oxygen is reported.
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01799A, Communication
From themed collection Contemporary Synthetic Chemistry in Drug Discovery
As a part of our ongoing synthetic quest to expand the frontiers of contemporary medicinal chemistry, we now report an expedient synthesis of a potentially useful bicyclo[1.1.1]pentane building block, 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic...
Daniel Mark Miles-Barrett, Andrew R Neal, Calum Hand, James R.D. Montgomery, Isabella Panovic, O Stephen Ojo, Christopher S Lancefield, David Bradford Cordes, Alexandra Slawin, Tomas Lebl and Nicholas J Westwood
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01915C, Paper
Understanding the structure of technical lignins resulting from acid-catalysed treatment of lignocellulosic biomass is important for their future valorisation. Here we report an investigation into the fate of lignin under...
Matthew Ball, Anne Baron, Ben Bradshaw, Raphaël Dumeunier, Matthew O'Brien and Eric J. Thomas
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01804A, Paper
Scaleable syntheses of the C1–C16 fragment of bryostatins are described.
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01618A, Review Article
Although diazoalkanes find regular application in organic synthesis, the synthesis and application of their fluorinated homologoues was long neglected. First described in 1943, Trifluorodiazoethane found its way into the organic...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01892K, Communication
A novel, efficient and enantioselective Heck−Matsuda desymmetrization of non-activated cyclopentene-fused spiro-pyrrolidinones was developed. The reaction provided the Heck products in good to excellent yields and selectivities, and tolerates a variety...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01733A, Paper
A novel and tunable α-hydroxylation/α-chlorination of benzyl ketone derivatives has been developed for the construction of hetero-quaternary carbon center by Iron(III) chloride hexahydrate mediated selective transformations through the application of...
Masahiro Okada, Tomotoshi Sugita, Kohei Akita, Yu Nakashima, Tian Tian, Chang Li, Takahiro Mori and Ikuro Abe
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01759B, Paper
The stereospecific prenylation of tryptophan by KgpF was determined by in vitro prenylation and chemical synthesis.
Daniel L. Priebbenow, Lisa Barbaro and Jonathan B. Baell
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01893A, Paper
New synthetic pathways for the preparation of bedaquiline analogues were developed to access improved pharmaceutical agents for treatment of MDR-TB.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01599A, Paper
An efficient asymmetric approach to dihydronepetalactone and dolicholactone is presented featuring a Julia olefination and an anion–radical–cation crossover reaction.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01841F, Communication
The use of polar DMF to relax the H-bonding-rigidified backbone leads to significantly improved yields for BOP-mediated one-pot synthesis of pentameric macrocycles.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01447J, Paper
A linear, chiron approach for the synthesis of C13–C24 fragments of cytostatic maltepolides A, C and D consisting of a tetrahydrofuran subunit and a chiral alkenyl/alkyl substituent is achieved from (+)-diethyl L-tartrate.
Simmi Sharma, Shaista Sultan, Shekaraiah Devari and Bhahwal Ali Shah
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01879C, Paper
Radical–radical cross coupling reactions of photoexcited 9-fluorenones have been accomplished for the first time, leading to the synthesis of 9-alkyl, pyrollidinyl and spiro-THF derivatives of 9-fluorenones.
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71 citations
Donor–acceptor cyclopropane annulations – not just for heterocycles.
DOI: 10.1039/C4OB02117G
Published: 13 Nov 2014
41 citations
This review article covers the main types of gold(i) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.
DOI: 10.1039/C5OB00736D
Published: 19 May 2015
35 citations
The recent advances in the copper-catalysed azide–alkyne cycloaddition (CuAAC) reactions are reviewed.
DOI: 10.1039/C5OB01457C
Published: 31 Jul 2015

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