Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
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Andreas Ekebergh, Christine Lingblom, Peter Sandin, Christine Wennerås and Jerker Mårtensson
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02694B, Paper
Design of Experiments (DoE) has been used to optimize a diversity oriented palladium catalyzed cascade Heck-Suzuki reaction for the construction of 3-alkenyl substituted cyclopenta[b]indole compounds. The obtained DoE model revealed...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00063G, Paper
A Lewis acid promoted highly diastereoselective asymmetric Friedel-Crafts alkylation of indoles with isatin-derived N-tert-butanesulfinyl ketimines is described. The reaction can be accomplished with ease in the presence of a catalytic...
Hongbo Cheng, Yao-Dong Huang, Lina Zhao, Xu Li and Hai-Chen Wu
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02619E, Paper
The potential implication of photochromic materials with absorption and reactivity in the near-infrared region is far-reaching. In this work, three novel bisindole-containing diarylethene derivatives 1o–3o have been successfully synthesized and...
Yves Blériot, jerome desire, yerri jagadeesh, Matthieu Sollogoub, bo luo, Yongmin Zhang, nicolas auberger, Atsushi Kato, Shinpei Nakagawa and Anh Tuan TRAN
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00050E, Paper
A series of pentahydroxylated pyrrolidines, displaying five contiguous stereogenic centres and epimeric to α-glucosidase inhibitor homoDMDP, have been synthesized. The key step involves a γ-aminoalcohol rearrangement applied to polyhydroxylated azepane....
Jing-Wen Qiu, Bo-Lun Hu, Xing-Guo Zhang, Ri-Yuan Tang, Ping Zhong and Jin-Heng Li
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02467B, Paper
A novel copper-catalyzed ring expansion of 2-aminobenzothiazoles to 1,4-benzothiazines is described.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02630F, Paper
For the first time it is shown that the pKa directly reflects the conformational equilibrium of conformers.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02614D, Paper
Electrostatically crosslinked bioreducible nanoparticles of polyethylenimine (DP NPs) have been prepared and evaluated for their cytotoxicity and capability to transport nucleic acids inside the cells.
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02514H, Communication
From themed collection Supramolecular Chemistry in Water
A supramolecular approach for modeling active sites of metallo-enzymes relies on the association of a metal ion bound to a tris(imidazole) core under the control of a cavity. One step...
Sylvain Ursuegui, Rodrigue Yougnia, Severine Moutin, Arnaud Burr, Christine Fossey, Thomas Cailly, Ali Laayoun, Alain Laurent and Frédéric Fabis
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02636E, Paper
Isatoic anhydride derivatives, including a biotin and a disulfide linker were specifically designed for nucleic acid separation. 2’-OH selective RNA acylation, capture of biotinylated RNA adducts by streptavidin-coated magnetic beads...
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB90021B, Correction
Lorena Paseta, Grégory Potier, Steven Abbott and Joaquín Coronas
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB90016F, Correction
Anna Siegbahn, Karin Thorsheim, Jonas Ståhle, Sophie Manner, Christoffer Hamark, Andrea Persson, Emil Tykesson, Katrin Mani, Gunilla Westergren-Thorsson, Goran Widmalm and Ulf Ellervik
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02632B, Paper
Proteoglycans (PGs) are macromolecules that consist of long linear polysaccharides, glycosaminoglycan (GAG) chains, covalently attached to a core protein by the carbohydrate xylose. The biosynthesis of GAG chains is initiated...
Ahmed Kamal, Santhosh Reddy Vangala, Anver Basha Shaik, Bharath Kumar G, Sowjanya Polepalli, Vishnuvardhan MVPS and Nishant Jainb
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02449D, Paper
A library of new pyrazole and isoxazole conjugates were synthesized and evaluated for their cytotoxic activity against various human cancer cell lines. These compounds have shown significant cytotoxicity with lower...
Xun Sun, Mingliang Wang, Xixi Liu, Lu Zhou and Jidong Zhu
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02691H, Communication
An efficient protocol was developed to access 3-fluoro-2-hydroxy-2-substituted benzo[b]furans with SelectfluorTM as the fluorinating reagent in MeCN and water. By utilizing SOCl2/Py as the dehydration agent, the compounds above were...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00064E, Communication
A rhodium-catalyzed hydroarylation of alkynes with aryl tetrazoles through tetrazole-directed C–H activation was developed. This procedure has broad substrate scopes, a variety of mono- and dialkenylated products were regioselectively obtained...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00013K, Paper
A new and convenient method for the synthesis of indolo[1,2-f]phenanthridines via palladium-catalyzed domino C-N coupling/hydroamination/C-H arylation reactions was developed. The reactions allow for the synthesis of various phenanthridines in good...
Taku Yoshiya, Hiromi Ii, Shugo Tsuda, Susumu Kageyama, Tatsuhiro Yoshiki and Yuji Nishiuchi
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00086F, Communication
Cancer-related γ-glutamyl cyclotransferase (GGCT) specifically converts γ-glutamyl amino acids (γ-Glu-Xaa) into pyroglutamate and the corresponding amino acids (Xaa). Here we report a novel GGCT fluorogenic probe “LISA-101”. Upon cleavage of...
John J. Molloy, Robert P. Law, James W. B. Fyfe, Ciaran P. Seath, David J. Hirst and Allan J. B. Watson
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00078E, Paper
Functionalised biaryl phenols can be rapidly accessed via one-pot Suzuki–Miyaura cross-coupling, chemoselective control of boron solution speciation, and oxidation.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02633K, Paper
A highly selective and effective, acid-promoted, electrophilic trifluoromethylthiolation of phenols is described.
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02670E, Paper
Three-component reaction between RCF2CH2NH2*HCl, NaNO2 and alkynes drastically depends on substituents “R” and “R1”. The reaction gives the fluorinated pyrazoles in high yields when “R” is fluorine atom or fluoroalkyl...
Akihiro Taguchi, Kentarou Fukumoto, Yuya Asahina, Akihiro Kajiyama, Shunsuke Shimura, Keisuke Hamada, Kentaro Takayama, Fumika Yakushiji , Hironobu Hojo and Yoshio Hayashi
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00030K, Communication
A new solid-phase disulfide ligation method is developed to prepare a disulfide peptide from two types of Cys-containing peptide fragments with minimum purification steps. In combination with the subsequent intramolecular...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00020C, Paper
A facile, efficient, single-step protocol for the synthesis of difluoromethyl enol ethers derivatives by O-difluoromethylation of 1,3-diones via in situ generation of difluorocarbene from ClCF2CO2Et has been developed. The functional...
Deborah A Smithen, Stephanie M. Forget, Nicole E McCormick, Raymond T Syvitski and David L Jakeman
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02583K, Paper
A series of polyphosphate containing sugar nucleotide analogues were synthesized and evaluated as bisubstrate inhibitors of α-D-glucose 1-phosphate thymidylyltransferase Cps2L, the first enzyme in Streptococcus pneumoniae L-rhamnose biosynthesis, and a...
Ravindra Pathak, Benjamin Dobson, Nandita Ghosh, Khalid Ageel, Madeha Alshawish, Rungroj Saruengkhanphasit and I Coldham
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02582B, Paper
An efficient synthetic approach to the core structure of the manzamine alkaloids is reported, particularly in relation to incorporating a one-carbon unit in ring B from which the aldehyde in...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00147A, Paper
Blocking the function of both heat shock protein 90 and 70 (Hsp90 and Hsp70) simultaneously limits these chaperones’ cytoprotective effects on cancer cells. The unique phenotype associated with modulating Hsp90’s...
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