Organic & Biomolecular Chemistry
Organic synthesis, supramolecular chemistry, chemical biology and more.On average get a first decision in 12 days for Communications and 18 days for Papers.
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Sneha Sudhakara and Anju Chadha
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00340D, Paper
DOI: 10.1039/C7OB00340D, Paper
Candida parapsilosis ATCC 7330, a rich source of highly stereospecific oxidoreductases, catalyzes oxidation-reduction of a plethora of compounds yielding industrially important intermediates. An (S)-specific carbonyl reductase (SRED) purified and characterized...
Ling-Li Han, Xingyu Zhang, Xingdong Wang, Fengyue Zhao, Shao-Jing Liu and Tao Liu
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00261K, Paper
DOI: 10.1039/C7OB00261K, Paper
The coupling reaction mechanisms of the Rh(III)-catalyzed redox-neutral C7-selective aryl C−H functionalization of indolines with alkynes and alkenes have been theoretically investigated with the aid of the density functional theory...
Takashi Osawa, Motoki Sawamura, Fumito Wada, Tsuyoshi Yamamoto, Satoshi Obika and Yoshiyuki Hari
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00698E, Paper
DOI: 10.1039/C7OB00698E, Paper
We synthesized thymidine derivatives of 2ʹ-C,4ʹ-C-ethyleneoxy-bridged 2ʹ-deoxyribonucleic acids with 8ʹ-methyl group ((R)-Me-EoDNA and (S)-Me-EoDNA) and without any substituent (EoDNA). Oligonucleotides including these EoDNAs showed high hybridization abilities with complementary RNA...
Dibakar Goswami, Mrunesh R. Koli, Sucheta Chatterjee, Subrata Chattopadhyay and Anubha Sharma
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00626H, Paper
DOI: 10.1039/C7OB00626H, Paper
Highly syn-selective crotylation of aldehydes was achieved using Bi-[bmim][Br]-crotyl bromide combination, leading to an easy, stereodivergent method to synthesise important targets.
Li Su, Rui Zhang, Kwaku Kyeremeh, Zixin Deng, Hai Deng and Yi Yu
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00617A, Communication
DOI: 10.1039/C7OB00617A, Communication
The biosynthetic origin of the C4 alkyl side chain in the “A” ring of neocarazostatin A was reconstituted in vitro.
S. R. K. Battula, V. P. Rama Kishore Putta, G. V. Subbareddy, I. E. Chakravarthy and V. Saravanan
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00601B, Paper
DOI: 10.1039/C7OB00601B, Paper
A divergent and metal free approach has been successfully developed for the synthesis of sulfoximine tethered heterocycles from a α-bromoalkanone building block.
Miguel Espinosa, Jorge Herrera, Gonzalo Blay, Luz Cardona, M. Carmen Muñoz and José R. Pedro
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00595D, Communication
DOI: 10.1039/C7OB00595D, Communication
A diastereo- and enantioselective Michael addition of methyl malonate to β-trifluoromethyl unsaturated imines is presented.
Micjel C. Morejón, Annegret Laub, Goran N. Kaluđerović, Alfredo R. Puentes, Ali N. Hmedat, Anselmo J. Otero-González, Daniel G. Rivera and Ludger A. Wessjohann
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00459A, Paper
DOI: 10.1039/C7OB00459A, Paper
Two birds in one shot: oligopeptides can be cyclized and lipidated in one step with multicomponent reactions.
Florian Klepel and Bart Jan Ravoo
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00667E, Communication
DOI: 10.1039/C7OB00667E, Communication
Photoinduced radical disulfide metathesis (PRDM) is a dynamic covalent reaction that requires UV light to induce the homolytic cleavage of the disulfide bond, thus offering the opportunity to construct dynamic covalent systems that are dormant and can be photo-activated on demand.
Elsa Deruer and Sylvain Canesi
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00326A, Paper
DOI: 10.1039/C7OB00326A, Paper
Treatment of aniline derivatives in the presence of a hypervalent iodine reagent and furan produces dihydrofuranoindoline cores in one step.
Yuchuan Guo, Lizhen Wang, Jiatong Guo, Guofeng Gu and Zhongwu Guo
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00555E, Paper
DOI: 10.1039/C7OB00555E, Paper
First-time expression, isolation, biochemical characterization, and mutagenesis studies of a MshA from Corynebacterium diphtheria involved in its mycothiol biosynthesis.
Hongguang Yang, Xiaoyu Liu, Xiaoyu Li, Xiang Shi, Feilong Yang, Xiaozhen Jiao and Ping Xie
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00539C, Paper
DOI: 10.1039/C7OB00539C, Paper
An efficient stereoselective synthetic approach to colomitides, 2,7-dioxabicyclo[3.2.1]octane-type natural products, is reported.
Min-Ching Chung, Yung-Hsiang Chan, Wen-Jung Chang and Duen-Ren Hou
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00528H, Paper
DOI: 10.1039/C7OB00528H, Paper
Hydroamination of 3-butynamine derivatives to give non-aromatic 2,3-dihydropyrroles was achieved by using PdCl2 or AuCl as the catalyst.
Siba Prasad Midya, Elumalai Gopi, Nishikant Satam and Irishi N. N. Namboothiri
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00529F, Paper
From themed collection 2017 Hot Articles in Organic and Biomolecular Chemistry
DOI: 10.1039/C7OB00529F, Paper
From themed collection 2017 Hot Articles in Organic and Biomolecular Chemistry
DABCO-ylides react as a one-carbon source with chalconimines to afford fused cyanopyrroles via [4 + 1] annulation and spirocyclopropanes via [2 + 1] annulation.
László Csaba Bencze, Alina Filip, Gergely Bánóczi, Monica Ioana Toşa, Florin Dan Irimie, Ákos Gellért, László Poppe and Csaba Paizs
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00562H, Paper
DOI: 10.1039/C7OB00562H, Paper
The substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum (PcPAL) towards the L-enantiomers of racemic styrylalanines rac-1a–d were extended by reshaping the aromatic binding pocket of the active site of PcPAL by point mutations of F137.
Ganga B Vamisetti, Raghunath Chowdhury and Sunil Kumar Ghosh
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00796E, Communication
DOI: 10.1039/C7OB00796E, Communication
First example of asymmetric organocatalyzed decarboxylative aldol reaction of β-ketoacids (aroylacetic acids) with α-ketophosphonates that produces a quaternary chiral centre has been developed. A quinidine based bifunctional urea derivative was...
Renzo Ruzziconi, Giuseppe Mazzeo, Giovanna Longhi, Sergio Abbate, Martina Palomba, Luana Bagnoli, Francesca Marini, Claudio Santi, Jianlin Han, Vadim A Soloshonok and Emilio Di Crescenzo
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00670E, Paper
DOI: 10.1039/C7OB00670E, Paper
A novel approach to regioselectively substituted and stereoselectively -trifluoromethylated tryptamines is reported based on the ene reaction of Boc-protected 3-methyleneindolines with optically pure (R)- or (S)-tert-butanesulfinyltrifluoroacetaldimine. Boc- and sulfinylamido-protected -trifluoromethyltryptamines...
Longlei Hou, Yuejie Yuan and Xiaofeng Tong
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00762K, Communication
DOI: 10.1039/C7OB00762K, Communication
A Pd(0)/(S)-p-MeO-BnPHOX catalytic system has been established for the asymmetric reductive Heck reaction of (Z)-1-iodo-1,6-diene, which affords quaternary tetrahydropyridines with good to excellent enantioselectivity. This reaction tolerates a wide range...
Chu-Han Sun, Yi Lu, Qing Zhang, Rong Lu, Lin-Qing Bao, Mei-Hua Shen and Hua-Dong Xu
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00040E, Communication
DOI: 10.1039/C7OB00040E, Communication
There exist three possible patterns for the reaction of cyclic 2-oxazolidinethione and 2-benzoxazolidinethione with aryne, namely (a) S-arylation, (b) N-arylation, and (c) aryne insertion into thiocarbonyl group (C=S). Our studies...
Zi-Song Cong, Yang-Guo Li, Lei Chen, fen xing, Cheng-Zhi Gu, Guangfen Du and Lin He
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00599G, Communication
DOI: 10.1039/C7OB00599G, Communication
A novel organocatalytic olefinic carbon-sulfur bonds forming reaction was developed. Under the catalysis of 10 mol% stable N-heterocyclic carbene, thiols undergo direct nucleophilic substitution reaction with gem-difluoroalkenes to produce α-fluorovinyl...
Taku Shoji, Shuhei Sugiyama, Takanori Araki, Akira Ohta, Ryuta Sekiguchi, Shunji Ito, Shigeki Mori and Tetsuo Okujima
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00691H, Paper
DOI: 10.1039/C7OB00691H, Paper
The SNAr reaction of 2-chloroazulene derivative 1 with ethoxycarbonyl groups at the 1,3-positions of azulene ring with several amines afforded the corresponding 2-aminoazulenes 3−9 in excellent yields. 2-Chloroazulene (2) without...
Huan-Ming Huang, Pablo Bonilla and David John Procter
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00739F, Paper
DOI: 10.1039/C7OB00739F, Paper
Radical-radical cyclisation cascades, triggered by single-electron-transfer to amide-type carbonyls using SmI2-H2O-LiBr, result in the selective construction of quaternary carbon stereocentres. The cascades deliver tricyclic barbiturates with four stereocentres in good...
Xianshun Zeng, Chang Liu, Xiaojie Jiao, Song He and Liancheng Zhao
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00538E, Paper
DOI: 10.1039/C7OB00538E, Paper
Copper plays important roles in a variety of fundamental physiological processes. At the cell organelles level, aberrant copper homeostasis in lysosomes can lead to various serious diseases. Herein, a bifluorophore-based,...
Hai-Lei Cui, Jiang-Fang Wang, Hai-Lin Zhou, Xiao-Lin You and Xiao-Jie Jiang
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00689F, Communication
DOI: 10.1039/C7OB00689F, Communication
We report here an unexpected catalyst free [2 + 2 + 2] annulation reaction which allows access to novel complex dimeric β-carboline derivatives in a single step. Various substituted ynone...
Benedetta Bertolotti, Ieva Sutkeviciute, Martino Ambrosini, Renato Ribeiro-Viana, Javier Rojo, Franck Fieschi, Hana Dvorakova, Martina Kašáková, Kamil Parkan, Martina Hlaváčková, Katerina Novakova and Jitka Moravcova
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00322F, Paper
DOI: 10.1039/C7OB00322F, Paper
The C-type lectin DC-SIGN expressed on immature dendritic cells is a promising target for antiviral drug development. Previously, we have demonstrated that mono- and divalent C-glycosides based on D-manno and...
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A unified strategy for the palladium-catalyzed Suzuki–Miyaura cross-coupling of amides with boronic acids for the synthesis of ketones by N–C bond activation is reported.
This review article covers the main types of gold(i) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.
The recent advances in the copper-catalysed azide–alkyne cycloaddition (CuAAC) reactions are reviewed.
