Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
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Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01580K, Paper
An efficient and practical synthetic approach to access of 2H-pyrrolo[3,4-c]quinolin-4(5H)-one/2H-pyrrolo[3,4-c]quinoline derivatives by the reaction of 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC) via one pot van Leusen reaction and cyclization under basic...
Ana Ramos, José María Zapico, Anna Puckowska, Kamila Filipiak, Claire Coderch and Beatriz de Pascual-Teresa
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01516A, Paper
MMP-2 is a validated target for the development of anticancer agents. Herein we describe the synthesis of a new series of potent phenylalanine derived hydroxamates, with increased MMP-2/MMP-9 selectivity compared...
Torbjörn Wixe, Niels Johan Christensen, Sven Lidin, Peter Fristrup and Kenneth Wärnmark
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01683A, Paper
A short helical nanotube having its aromatic system perpendicular to its axis of propagation was synthesized and its properties were studied.
Takuji Kawamoto and Ilhyong Ryu
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01784F, Review Article
Borohydrides are an important class of reagents in both organic and inorganic chemistry. Though popular as hydride-transfer reagents for reduction, since earlier work from the 1970s, borohydride reagents have also...
Anjani K Tiwari, Masayuki Fujinaga, Joji Yui, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Anil K Mishra, Yoko Shimoda, Akiko Hatori, Bin Ji, Masanao Ogawa, Kazunori Kawamura, Feng Wang and MR Zhang
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01933D, Paper
Visualization of activated microglia/TSPO is one of the main aspects of neuroimaging. Here we are describing two new 18F-labelled molecules, 2-[5-(4-[18F]fluoroethoxy- ([18F]2) and 2-[5-(4-[18F]fluoropropyloxy- ([18F]3) -2-oxo-1,3-benzoxazol-3(2H)-yl)-N-methyl-N-phenyl acetamide as novel PET...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01979B, Communication
2H-Chromene is important structural motif that exists in natural products and non-natural compounds possessing interesting biological activities. In this investigation, a highly efficient approach toward 2H-chromenes has been developed based...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01714E, Paper
N-(α-ketoacyl)anthranilic acids reacted with phenylhydrazinium chloride in boiling acetic acid to afford 2-(indol-2-carboxamido)benzoic acids in good to excellent yields and 2-indolyl-3,1-benzoxazin-4-ones as by-products. The formation of the latter products could...
chenchen chen, Yi-Chao Huang, ling xu, yong zheng, Hua-Jian Xu, Qingxiang Guo, Changlin Tian, Yiming Li and Jing Shi
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01885K, Paper
An efficient thiol-assisted one-pot synthesis of peptide/protein C-terminal thioacids was achieved by using peptide/protein hydrazides precursors at neutral pH and room temperature (about 20 oC). The transformation from hydrazides to...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01912A, Paper
A simple and efficient protocol for the oxidative ortho benzoxylation of 2-phenylpyridines with benzyl alcohols and benzyl amines via C−H bond activation has been developed. Present protocol uses benzyl alcohol...
Marco Franceschin, Daniele Nocioni, Annamaria Biroccio, Chiara Cingolani, Emanuela Micheli, Stefano Cacchione, Alessandro Venditti, Pasquale Zizza, Armandodoriano Bianco and alessandro altieri
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01658K, Paper
Following the results we previously reported on a series of xanthene and xanthone derivatives as G-quadruplex stabilizing ligands, in order to obtain a more selective compound with respect to the...
Mark Stephen Betson, Nigel Allanson and Philip Wainwright
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01449A, Review Article
Modified nucleosides have received a great deal of attention from the scientific community, either for use as therapeutic agents, diagnostic tools, or as molecular probes. Perhaps the most difficult position...
subhash ghosh, Balla Chandrasekhar, Sudhakar Athe and Purushotham Reddy Pothula
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01716A, Paper
The communication reported the synthesis of fully functionalized aglycone of lycoperdinoside A and B. Pd-catalyzed Stille–Migita cross coupling between E-vinyl iodide 6 and E-vinyl stannane 23 established the highly substituted...
Rong-Rong Zhang, Hai-Yan Tian, Ya-Fang Tan, Tse-Yu Chung, Xiao-Hui Sun, Xue Xia, Wen-Cai Ye, David A. Middleton, Natalya Fedosova, Mikael Esmann, Jason T. C. Tzen and Ren-Wang Jiang
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01545B, Paper
New cardenolides with potent cytotoxic and Na+,K+-ATPase inhibitory activities were isolated from the ornamental milkweed Asclepias curassavica.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01646G, Communication
A highly enantioselective intramolecular 6-exo-trig aza-Michael addition was developed to afford chiral 3-substituted 1,2-oxazinanes in high yields (up to 99% yield) and good enantioselectivities (up to 98/2 er).
Alexander Henderson, John Bower and M. Carmen Galan
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02056A, Paper
Versatile syntheses of C2-linked and C2-symmetric carbohydrate-based imidazol(in)ium salts from functionalised amino-carbohydrate derivatives are reported. The novel NHCs were ligated to [Rh(COD)Cl]2 and evaluated in Rh catalyzed asymmetric hydrosilylation of...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01596G, Communication
Rh(III)-catalyzed efficient C-H alkynylation of azomethine imines with alkynylated hypervalent iodine has been developed under mild conditions. A broad scope of azomethine imine and alkyne substrates has been established. The...
Jingjie Tang, Mei Cong, Yi Xia, Gilles Quelever, Yuting Fan, Fanqi Qu and Ling Peng
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01836B, Paper
Various arylvinyltriazole nucleoside analogues were synthesized using Pd-catalyzed oxidative Heck reaction. This method affords the corresponding and otherwise difficult to achieve arylvinyltriazole nucleosides with good yields and large functional group...
Lingling Feng, Junbo He, Haifeng He, Lulu Zhao, Lingfu Deng, Li Zhang, Lin Zhang, Yanliang Ren, Jian Wan and Hongwu He
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01347F, Paper
Optimal binding mode for the novel potent inhibitor 4j against PDHc-E1 from E. coli.
John C. Lukesh III, Kristen A. Andersen, Kelly K. Wallin and Ronald T. Raines
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01738B, Communication
Organocatalysts derived from ethylenetriamine and containing a hydrophobic moiety effect the isomerization of non-native protein disulfide bonds to native ones.
Boris Aillard, Naomi S. Robertson, Adam R. Baldwin, Siobhan Robins and Andrew G. Jamieson
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01832J, Paper
The efficient asymmetric synthesis of unnatural alkenyl amino acids required for peptide ‘stapling’ has been achieved using alkylation of a fluorine-modified NiII Schiff base complex as the key step.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01418A, Communication
The impact of LR-HSQMBC very long-range nJCH heteronuclear shift correlation data as a supplement to HMBC data as input for the computer-assisted structure elucidation program, Structure Elucidator®, is assessed for the first time.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01736F, Communication
A rhodium(III)-catalyzed ortho-cyanation of symmetrical azobenzenes with NCTS via azo-group-directed C(sp2)–H bond activation is described.
Jun-Jiang Lv, Ya-Feng Wang, Jing-Min Zhang, Shan Yu, Dong Wang, Hong-Tao Zhu, Rong-Rong Cheng, Chong-Ren Yang, Min Xu and Ying-Jun Zhang
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01196A, Paper
The sesquiterpenoid glycoside dimers isolated from Phyllanthus emblica have anti-HBV activities towards HBsAg and HBeAg secretions inhibition.
Roberta Majer, Olga Konechnaya, Ignacio Delso, Tomas Tejero, Orazio A. Attanasi, Stefania Santeusanio and Pedro Merino
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01371A, Paper
Asymmetric 1,3-dipolar cycloadditions between 1,2-diaza-1,3-dienes and chiral non-racemic nitrones to give 3-substituted-5-diazenyl isoxazolidines were studied.
Di Wu, Haojie Ge, Zhao Chen, Jinhua Liang, Jie Huang, Yufeng Zhang, Xiaoqiang Chen, Xianggao Meng, Sheng Hua Liu and Jun Yin
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01486C, Paper
Imide-modified polycyclic aromatic hydrocarbons can be widely applied in the field of optoelectronic materials.
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