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Organic & Biomolecular Chemistry

Rapid publication of high quality organic chemistry research
Impact Factor 3.559 48 Issues per Year Indexed in Medline
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Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01584K, Paper
The binding between peptides and DNA is often driven by entropic forces. We demonstrate herein a new approach to shift the thermodynamic profile of peptide/DNA binding from entropy to enthalpy...
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01407K, Paper
An efficient one-pot procedure for the synthesis of new pyrazolo[1,5-a]quinoxalin-4(5H)-ones from easily prepared 1-(2-chlorophenyl-5-ethylcarboxylate)pyrazoles and various primary alkylamines is described.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01738J, Paper
Synthesis of (−)-hortonones A–C from vitamin D2 reveals that the natural products are of opposite absolute configuration to originally proposed.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01588C, Paper
Tetra-porphyrin molecular tweezers linked by rigid polycyclic arms, capable of interannular cooperativity, are synthesised using imide–boronic acid coupling.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01635A, Paper
A halogen bond is unlikely to control the conformation of cis-1,3-disubstituted cyclohexanes. In addition, polarization rather than the σ-hole effect describes this weak interaction more appropriately.
Guilong Cai, Zhibing Zhou, Wenchao Wu, Bo Yao, Shaowen Zhang and Xiaofang Li
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01765G, Paper
The Pd-catalyzed cross-coupling with the Hosomi–Sakurai reaction led to a novel three-component reaction using Y(CH2SiMe3)3(THF)2 as a nucleophilic one-carbon synthon.
M. Kvasnica, J. Oklestkova, V. Bazgier, L. Rárová, P. Korinkova, J. Mikulík, M. Budesinsky, T. Béres, K. Berka, Q. Lu, E. Russinova and M. Strnad
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01479H, Paper
Synthesis of new brassinosteroid analogues based on molecular docking into the BRI1 receptor leads to novel compounds with bioactivity comparable to natural ones.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01414C, Review Article
A number of aggregation-induced emission (AIE) probes with high photostability and specificity have been developed for organelle imaging and image-guided cancer cell ablation.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01348A, Paper
From themed collection Contemporary Synthetic Chemistry in Drug Discovery
A simple method for the synthesis of trifluoromethylthiolated pyridinones through the copper-mediated trifluoromethylthiolation of iodopyridinones was developed.
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01648K, Review Article
3-Hydroxyindanone is an important scaffold in many natural products, biologically active compounds, and functional materials. This review provides a comprehensive overview of the construction of 3-hydroxyindanone derivatives and their applications...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01452F, Paper
A Cu(I)-catalyzed retro-aldol reaction of β-hydroxyketones with ortho-aminobenzaldehydes and nicotinaldehydes is reported that produces a range of quinolines and naphthyridines with high efficiency and selectivity. This reaction uses β-hydroxyketones as...
Sarah R. Rundell, Zachary L. Wagar, Lisa M. Meints, Claire D. Olson, Mara K. O'Neill, Brent F. Piligian, Anne W. Poston, Robin J. Hood, Peter J. Woodruff and Benjamin M. Swarts
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01734G, Paper
FDTre analogues were synthesized and purified in 60 min, confirmed to mimic the solution conformation of native trehalose, and successfully metabolized by the mycobacterial trehalose-recycling transporter.
Ryan A. Davis, Kevin Lau, Sven H Hausner and Julie L. Sutcliffe
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01636G, Communication
Solid-phase peptide synthesis, head-to-tail cyclization, and subsequent radiolabeling provided a reproducible, simple, rapid synthetic method to generate the cyclic peptide radiotracer cRGDyK([18F]FBA). Herein is reported the first on-resin cyclization and...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01854H, Communication
Air-stable N-sulfonyl and N-phosphonyl DBN hexafluorophosphate salts have been synthesised under mild conditions as sulfonylating and phosphonylating agents. These salts are highly efficient in the sulfonylation and phosphonylation of a...
Akhilesh K. Verma, Sonu Kumar, Rakesh K Saunthwal, Trapti Aggarwal and Siva K. Reddy Kotla
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01539E, Paper
An efficient step-economical tandem approach for the direct synthesis of pyrido fused indoles, quinolines, benzofurans and bezothiophenes derivatives using bimetallic Pd/Cu catalytic system has been described. The three component reaction...
Venkata Subba Reddy Basireddy, Dhanraj O Biradar, Yeturi Vikram Reddy, Jhillu S. Yadav, Kiran Kumar Singarapu and Sridhar Balasubramanian
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01686C, Paper
A novel bicyclization strategy has been developed for the stereoselective synthesis of bicyclic lactones, i.e. 7-aryl or alkyl-2,6-dioxabicyclo[3.3.1]nonan-3-ones through a domino cyclization of (R)-3-hydroxyhex-5-enoic acid with aldehyde in the presence...
Vania Bernardes Génisson, Julie Laborde, Céline Deraeve, Carine Duhayon and Genevieve Pratviel
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01561A, Paper
Ethionamide (ETH), a second-line anti-tubercular drug that is regaining lot of interest due to the increasing cases of drug-resistant tuberculosis, is a pro-drug that requires an enzymatic activation step to...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01163B, Paper
From themed collection Selective Chemistry with Peptides and Proteins
In this paper, we have used total chemical synthesis of RNase A analogues in order to probe the molecular basis of enzyme catalysis. Our goal was to obligately fill the...
Seungyoon Kang, Suji Lee, Woojin Yang, Jiwon Seo and Min Su Han
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01360K, Paper
In this study, we report a direct fluorometric assay for butyrylcholinesterase (BChE) activity and screening of its inhibitor, using a fluorescent substrate. 2-(2-(5,6-dimethoxy-1,3-dioxoisoindolin-2-yl)acetoxy)-N,N,N-trimethylethan-1-ammonium iodide (1) was hydrolyzed by BChE, and...
Alessandra Meli, Stefania Gambaro, Chiara Costabile, Carmen Talotta, Giorgio Della Sala, Paolo Tecilla, Domenico Milano, Massimo Tosolini, Irene Izzo and Francesco De Riccardis
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01683A, Paper
An efficient protocol for the solid-phase synthesis of six members of a new class of extended macrocyclic peptoids (based on the ortho-, meta- and para-N-(methoxyethyl)aminomethyl phenylacetyl units) is described. Theoretical...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01527A, Paper
Phophorylated cyclopropanes, generated via the Rh(II)-catalysed intramolecular cyclopropanation of α-(diethoxyphosphoryl)acetates, have been found to be useful precursors in the synthesis of α-alkylidene-γ-butyrolactones. These cyclopropyl intermediates undergo regioselective reductive ring-opening and...
Pierre-Michel Regenass, Stéphanie Riché, Florent Peron, Didier Rognan, Marcel Hibert, Nicolas Girard and Dominique Bonnet
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01434H, Paper
A rapid and atom economy multicomponent synthesis of complex aza-diketopiperazines (aza-DKPs) driven by Rh(I)-catalyzed hydroformylation of alkenylsemicarbazides is described. Combined with catalytic amounts of acid and the presence of nucleophilic...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01671E, Paper
A short, convergent and general strategy for stereoselective total synthesis of biologically active α-substituted γ-hydroxymethyl γ-lactone based natural products cananginone C and debilisone A has been developed. The salient features...
Kaitlin G. Henry, Lachlan Blair, Jonathan Sperry and Elizabeth Colby Davie
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01685E, Paper
The dimeric natural product montamine was originally reported as two N-feruloylserotonin (moschamine) units linked by a nitrogen-nitrogen bond, but our recent synthesis of this symmetrical diacyl hydrazide structure revealed this...
Xiong Wei, Danlin Liang, Qing Wang, Xiangbao Meng and Zhongjun Li
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01622G, Paper
Total synthesis of mangiferin, homomangiferin, and neomangiferin, three C-glycosyl xanthone natural products with a wide spectrum of pharmacological effects, have been achieved starting from 2,3,4,6-tetra-O-benzyl-glucopyranose. The key steps involve a...
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65 citations
Donor–acceptor cyclopropane annulations – not just for heterocycles.
DOI: 10.1039/C4OB02117G
Published: 13 Nov 2014
38 citations
This review article covers the main types of gold(i) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.
DOI: 10.1039/C5OB00736D
Published: 19 May 2015
32 citations
The recent advances in the copper-catalysed azide–alkyne cycloaddition (CuAAC) reactions are reviewed.
DOI: 10.1039/C5OB01457C
Published: 31 Jul 2015

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