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Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in Medline
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Ahmed Kamal, Yellaiah Tangella, Manasa Lakshmi Kesari, Sathish Manda, vunnam srinivasulu, Chetna Jadala and Abd-Allah Alarifi
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00871A, Paper
Iodobenzene diacetate was employed as a mild and efficient reagent for one-pot oxidative decarboxylation of tetrahydro-β-carboline acids and dehydrogenation of tetrahydro-β-carbolines to access corresponding fully aromatized β-carbolines. To the best...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00862J, Paper
8-Aza-3,7-dideaza-2'-deoxyadenosine 1 and its C3-naphthylethynylated derivative 3n7zA (2) comprising a 8-aza-3,7-dideazapurine (pyrazolo[4,3-c]pyridine) skeleton were synthesized for the first time. In particular, nucleoside 3n7zA (2) exhibited environmentally sensitive intramolecular charge transfer...
Kelu Yan, Daoshan Yang, Wei Wei, Jing Zhao, Yuanyuan Shuai, Laijin Tian and Hua Wang
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00769K, Paper
A novel, efficient, and catalyst-free strategy has been initially developed for the construction of thioesters via the direct radical oxidative decarboxylation of α-keto acids with thiols, and the corresponding target...
Jun Yin, Ziyong Li, xie han, Haiyan Chen, Di Wu, Fang Hu and Shenghua Liu
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00864F, Paper
Mechanically interlocked structures such as rotaxane and catenane provide a novel backbone for constructing the functional materials with a unique structural characterization. In this work, we design and synthesize a...
Shohei Takase, Yusuke Saga, Nozomi Kurihara, Shingo Naraki, Kenta Kuze, Genki Nakata, Takeshi Araki and Tetsuo Kushiro
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00714C, Paper
Oxidosqualene cyclases (OSCs) catalyze the cyclization of an acyclic substrate into various polycyclic triterpenes through a series of cation-π cyclization and 1,2-rearrangement processes. The mechanisms by which OSCs control the...
Joel R. Kosowan, Zemane W'Giorgis, Ravneet Grewal and Tabitha E. Wood
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00812C, Paper
This study of the Truce–Smiles rearrangement has revealed interesting tandem reactions, unprecedented systematic substituent effects, and new mechanistic insight.
Amandeep Kaur, Kurt W. L. Brigden, Timothy F. Cashman, Stuart T. Fraser and Elizabeth J. New
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00928F, Communication
NpFR2 is a fluorescent sensor that can reversibly measure changes in the mitochondrial redox environment.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00520E, Communication
A CuX2-mediated halocyclization of γ,δ-unsaturated amides for the synthesis of functionalized iminolactones and lactams respectively is described.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00695C, Paper
Two unique carbazole–indole-type dimeric alkaloids, glycosmisines A (1) and B (2), have been isolated from the stems of Glycosmis pentaphylla and their structures are elucidated by 1D and 2D NMR analyses).
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00806A, Paper
4-(Dimethylamino)pyridine functioned as an excellent catalyst for iodolactonization reactions of γ,δ-unsaturated carboxylic acids, affording γ-lactones, δ-lactones, or both.
Vutukuri Prakash Reddy, Renhua Qiu, Takanori Iwasaki and Nobuaki Kambe
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00149H, Paper
The sulfenylation and sulfonylation of (sp2)C–H bonds of benzamides were achieved with the aid of a bidentate directing group.
Sudip Pal, Gajendra Singh, Shyam Singh, Jitendra Kumar Tripathi, Jimut Kanti Ghosh, Sudhir Sinha, Ravi Sankar Ampapathi and Tushar Kanti Chakraborty
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00622H, Paper
Replacement of the D-Phe-Pro units of GS with novel C6-Bn-substituted tetrahydrofuran amino acid minimized its cytotoxicity while preserving its antimicrobial activity, with a few analogs showing selective anti-TB activity as well.
Huaqing Duan, Zhong Chen, Li Han, Yulin Feng, Yongming Zhu and Shilin Yang
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00472A, Paper
A simple and efficient strategy for the synthesis of indane-1,3-dione derivatives through a palladium(0)-catalyzed reaction incorporating tert-butyl isocyanide has been developed.
K. S. Sindhu, Amrutha P. Thankachan, P. S. Sajitha and Gopinathan Anilkumar
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00697J, Review Article
The classical heterocoupling of a 1-haloalkyne with a terminal alkyne catalyzed by copper salts in the presence of a base for the synthesis of unsymmetrical diynes is termed the Cadiot–Chodkiewicz coupling reaction.
Kun-Quan Chen, Han-Ming Zhang, Dong-Ling Wang, De-Qun Sun and Song Ye
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00859J, Communication
Chiral disubstituted indenopyrones were synthesized in high yields with exclusive cis-selectivity and excellent enantioselectivity via N-heterocyclic carbene catalysis.
Mickaël J. Fer, Ahmed Bouhss, Mariana Patrão, Laurent Le Corre, Nicolas Pietrancosta, Ana Amoroso, Bernard Joris, Dominique Mengin-Lecreulx, Sandrine Calvet-Vitale and Christine Gravier-Pelletier
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00707K, Paper
The synthesis of 5′-methylene-[1,4]-triazole-substituted aminoribosyl uridines is described. Their biological evaluation was performed and rationalized by molecular modeling.
Miu Shan Chan, Di Xu, Lei Guo, Dick Yan Tam, Ling Sum Liu, Man Shing Wong and Pik Kwan Lo
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00643K, Paper
We report the first example of a novel two-photon active, biocompatible, and macrophage cell-membrane permeable carbazole-based cyanine fluorophore for detection of three biologically important ROS namely, .OH, O2− and OCl−...
Vanessa Kar-Yan Lo, Anna On-Yee Chan and Chi-Ming Che
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00407A, Review Article
A summary of gold (including AuNPs, Au(I) and Au(III) complexes) and silver(I) catalysis and their application in bioconjugation reactions.
Yogesh Siddaraju and Kandikere Ramaiah Prabhu
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00684H, Paper
A novel method for α-hydroxylation of ketones using substoichiometric amount of iodine under metal-free conditions is described.
Leandro de C. Alves, André L. Desiderá, Kleber T. de Oliveira, Sean Newton, Steven V. Ley and Timothy J. Brocksom
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00525F, Paper
A route to enantiopure (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1, an intermediate for terpenoids, has been developed and includes a highly chemo- and regioselective Tiffeneau–Demjanov reaction.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00500K, Paper
A theranostic prodrug for mechlorethamine has been developed for photo-controlled release and monitoring by fluorescence spectroscopy.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00283D, Communication
Adding 2-hydroxyisobutyryl lysine to the genetic code of E. coli is reported.
Antonella Virgilio, Veronica Esposito, Luciano Mayol, Concetta Giancola, Luigi Petraccone and Aldo Galeone
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00748H, Paper
The effects of 5-hydroxymethyl-2′-deoxyuridine on two human telomeric G-quadruplexes have been investigated. Reported results suggest a possible protecting effect of the loop residues on the other parts of the structure.
Sebastian Reimann, Silvio Parpart, Peter Ehlers, Muhammad Sharif, Anke Spannenberg and Peter Langer
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00866B, Paper
Chemoselective Suzuki-Miyaura reactions on 3,5-dibromo-2,6-dichloropyridine were studied. The optimized reaction conditions allow for the facile access of 3-aryl- and 3,5-diarylpyridines in good yields. Suzuki-Miyaura reactions of the selectively synthesized 2,6-dichloro-3,5-diarylpyridines...
xin zhou, xue wu, juan xiao, chunmei jin, Zhixue Liu, Shujing Guo and xiaochuan zhang
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00710K, Paper
1-benzyl-3-(substituted aryl)-5-methylfuro[3, 2-c]pyrazoles (YC-1) is a well-known synthetic compound with various satisfactory pharmacological activities, such as the activation of soluble gualylate cyclase (sGC) and the inhibition of hypoxia-induced factor-1 (HIF-1)....
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