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Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

Rapid publication of high quality organic chemistry research
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Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02108E, Paper
In the pharmaceutical industry the sulfurisation of nucleotide-phosphites to produce more biologically stable thiophosphates is often achieved using ‘aged’ solutions of phenylacetyl disulfide (PADS) which consist of a mixture of...
Meng Sun, Zhe Wang, Jiaxin Wang, Peiyu Guo, Xiangxiang Chen and Ya-Min Li
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02040B, Communication
A palladium catalyzed efficient strategy for regio-selective ortho-arylation of sulfoxides with aryl acyl peroxides via decarboxylation has been developed. This reaction proceeds smoothly, tolerates a variety of functional groups, and...
Yi-Wen Liu, Pan Han, Wen Zhou, Zhuo-Ya Mao, Chang-Mei Si and Bangguo Wei
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02212J, Paper
A diastereoselective new approach for synthesis of trans-4-hydroxy-5-allyl-2-pyrrolidinone 9 has been developed through In-mediated allylation of α-chiral aldimines 8 with allyl bromide. The stereochemistry at C-5 stereogenic center of 9...
xue lei pang, Dongyan Xie, Xudong Yu, Yajuan Li, Li Jun Geng, jujie Ren and Xiaoli Zhen
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02007K, Paper
Facile tuning of fluorescent properties of organogels are highly desirable for the optical switches, light-emitting diodes, chemosensors and bioprobes. Design of organic molecules with multiple emission color by only one...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02234K, Paper
CREBBP bromodomains, epigenetic “reader” proteins that recognize acetylated histone lysine residues, are a current target for cancer therapy. We show that experimental CREBBP binding affinities of small-molecules with aromatic or...
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01910B, Perspective
The molding of molecules through remote functionalisation has increasingly become popular as it provides original and flexible synthetic alternatives to classical retrosynthetic analysis.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB02136K, Communication
A novel silver-catalyzed nucleophilic substitution of aminals with ethyl diazoacetate producing β-amino-α-diazoesters has been developed. A series of aminals with different amino moieties and substituents were successfully incorporated in this reaction.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB02271E, Paper
Practical Z-selective alkyne semihydrogenations can be achieved with an air-stable and preactivated copper(I) hydroxide complex.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02099B, Review Article
An overview of the methods for the formation and reaction of acyl hydrazides.
Giorgio Olivo, Simone Giosia, Alessia Barbieri, Osvaldo Lanzalunga and Stefano Di Stefano
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01984F, Paper
A cheap and easily available catalyst for alcohol oxidation with unexpected selectivity features.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB02154A, Paper
A novel approach for the synthesis of naphthoquinone/naphthoquinol–carbohydrate hybrids using the Hauser annulation as the key synthetic step has been described.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB02089E, Communication
A reactive cyclic iminium induced one-pot Groebke–Blackburn–Bienayme (GBB) double annulation cascade (DAC) for the synthesis of skeletally diverse DHIQ salts has been described. The key features of this protocol are solvent-free, robust method, clean reaction profile and operational simplicity.
Xiaolei Ji and Hanmin Huang
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01976E, Review Article
In this review, the synthetic methods for the preparation of 1,3-diamines and their applications in synthetic organic chemistry are summarized.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB02163H, Communication
This work reports the synthesis of quinazolines from 2-aminobenzylamines with N-substituted benzylamines in the presence of molecular iodine. The developed methodology works smoothly under transition-metal free, additive free and solvent free conditions and the use of O2 as a green oxidant makes it a greatly economical.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01462C, Review Article
This review sheds light on the effect of the structural modification of sugar amines on their catalytic efficiency and the stereoselectivity of the reaction.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01682K, Paper
The potential of compounds combining both a macrocyclic building block and two hydroxyl-bearing side arms to act as carbohydrate receptors was studied.
Toru Hatanaka, Ryosuke Yuki, Ryota Saito and Kaname SASAKI
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02256A, Communication
α-Methylphenacyl (Mpa) thioesters are described as precursors of thioacids. Mpa thioesters are accessible via the condensation of carboxylic acids and phenacyl thiol, which is easily prepared without column chromatography. The...
Cintia Anton-Torrecillas, Diego Felipe-Blanco and Jose C. Gonzalez-Gomez
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB02103D, Paper
Addition of ethers and acetals to 2-isocyanobiaryls: a radical cascade promoted under mildly basic aqueous conditions.
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02110G, Paper
Fluorescent derivatives of the archetypal antimalarial quinine and its diastereomer, quinidine, suitable for cellular imaging have been synthesised by attaching the small extrinsic fluorophore, NBD. Interactions of these derivatives with...
john southern, David Mangan, Neasa McNabola, Isabel Bermudez-Diaz, Susan Wonnacott and Emily Clarke
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01974A, Communication
A new synthesis of mecamylamine – a known anti-hypertensive drug with anti-addicitve properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine...
Yao Liu, Chu-Jun Zhou, Qingjiang Li and Honggen Wang
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB02049F, Communication
The first total synthesis of structurally unique polycyclic phenolic meroterpenoids, ganocins B and C is reported.
Márcia Pessêgo, Sandra Gago, Nuno Basílio, César A. T. Laia, A. Jorge Parola, João C. Lima and Fernando Pina
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01607C, Paper
Rigidifying 4′,7-dihydroxyflavylium prevents the formation of trans-chalcone (Ct). The addition of CTAB micelles unveils Ct enabling photochromism. Disrupting the micelles with α-cyclodextrin returns the system to its initial state.
Yuichi Kobayashi, Masao Morita, Narihito Ogawa, Daiki Kondo and Toshifumi Tojo
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02141G, Paper
Natural 12-hydroxyheptadecatrienoic acid (12-HHT) with S configuration was synthesised by a Suzuki-Miyaura coupling of C10–C17 iodo alcohol with C1–C9 vinylborane. The iodo alcohol was synthesised by utilising Sharpless asymmetric epoxidation...
Ping Liu, Guanghui Zhang and Peipei Sun
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02101H, Review Article
This review summarizes decarboxylative alkylation of carboxylic acids and their derivatives under transition metal-free conditions in recent years. Unlike most transition metal-catalyzed decarboxylative coupling reactions undergo catalytic cycles, the mechanisms...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01942K, Paper
When 2-(phenylethynyl)pyridine was oxidized, the formed N-oxide immediately cyclized at the ethynyl group to form isoxazolo[2,3-a]pyridinium salt. This salt underwent Reissert-Henze-type reactions with alcohol in the presence of a base...
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74 citations
Donor–acceptor cyclopropane annulations – not just for heterocycles.
DOI: 10.1039/C4OB02117G
Published: 13 Nov 2014
45 citations
This review article covers the main types of gold(i) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.
DOI: 10.1039/C5OB00736D
Published: 19 May 2015
39 citations
The recent advances in the copper-catalysed azide–alkyne cycloaddition (CuAAC) reactions are reviewed.
DOI: 10.1039/C5OB01457C
Published: 31 Jul 2015

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