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Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

Organic synthesis, supramolecular chemistry, chemical biology and more.
On average get a first decision in 12 days for Communications and 18 days for Papers.
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Alicia Megia-Fernandez, Bethany Mills, Chesney Michels, Sunay V Chankeshwara, Kevin Dhaliwal and Mark Bradley
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00663B, Paper
A library of FRET-based peptides were prepared and studied as Thrombin substrates. This identified probes that showed selective activation by Thrombin, low background signal, stability to Factor Xa, matrix metalloproteases,...
John Waller, Helen Toogood, Vijaykumar Karuppiah, Nicholas John William Rattray, David Mansell, David Leys, John M Gardiner, Anna Fryszkowska, Syed Ahmed, Rakeshwar Bandichhor, Prashanth Reddy Gaddameedhi and Nigel Scrutton
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00163K, Paper
Reduction of double bonds of α,β-unsaturated carboxylic acids and esters by ene-reductases remains challenging and it typically requires activation by a second electron-withdrawing moiety, such as a halide or second...
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00958E, Paper
A new method has been developed for the selenocyanation of aromatic ketones. This reaction avoids the need to use pre-prepared α-halo ketones, providing rapid access to α-carbonyl selenocyanates. We also...
Diana Gimenez, Anica Dose, Nicholas L. Robson, Graham Sandford, Steven L. Cobb and Christopher R. Coxon
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00295E, Communication
Trifluoroethanol enables selective perfluoro-heteroaromatic peptide arylation of cysteine residues.
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00791D, Paper
Ascorbic acid is a well-known antioxidant and radical scavenger. It can be oxidized by losing two protons and two electrons, but normally loses only one electron at a time. The...
bo Huang, Wen Chen, Yong-Qing Kuang, Wei Liu, Xianjun Liu, Li-Juan Tang and Jian-Hui Jiang
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00781G, Paper
Sensitive and selective detection and imaging of nitroreductase (NTR) in cancer cells is of great importance for better understanding their biological functions. Since there are few fluorescent probes concerning NTR...
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00189D, Perspective
Chimeragenesis is an effective tool to probe the structure/function relationships of proteins without high-throughput screening systems. Here the proof-of-principle is presented with three pairs of proteins.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00779E, Paper
An efficient synthesis of 3-ethyl-3-methyl oxindoles by visible-light promoted and iron-catalyzed difunctionalization of N-arylacrylamides with dimethyl sulphoxide was developed.
Li-Ming Zhao, hua-shuai gao, De-Feng Li, Jing Dong, Lan-Lin Sang and Jie Ji
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00723J, Paper
We report a simple, efficient, and general method for the zinc-mediated regioselective cinnamylation of aldehydes and ketones under Barbier-type conditions in a one-pot synthesis affording the corresponding α-cinnamylated alcohols in...
Chaleena Pimpasri, Ladawan Sumunnee and Sirilata Yotphan
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00776K, Paper
A copper-catalyzed oxidative decarboxylative coupling of α-keto acids with NH-sulfoximines has been developed. With CuBr as the catalyst and K2S2O8 as the oxidant, this reaction enables the formation of C...
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00897J, Paper
Tricyclic indolines are common in both natural products and synthetic chemical probes. In this study we demonstrated that enantiomerically pure tricyclic indolines can be prepared from an inexpensive commmercially available...
Fangfei Li, Anil K. Gorle, Marie Ranson, Kara L. Vine, Robert Kinobe, Marshall Feterl, Jeffrey M. Warner, F. Richard Keene, J. Grant Collins and Anthony I. Day
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00724H, Paper
The pharmacokinetics of cucurbit[7, 8 and 10] were evaluated in rats and mice, using 14C-labelled Q[7 and 8] and a dinuclear ruthenium complex encapsulated in Q[10].
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00882A, Paper
An efficient new method was developed for the synthesis of 2-halo allylic aminal derivatives through regioselective 1,2-addition of allenamides with N-haloimides.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00777A, Communication
A base-promoted dearomative annulation between N-2-pyridylamidine and an atmospheric pressure of CO2 was developed, affording a series of pyrido[1,2-a]-1,3,5-triazin-4-ones in moderate to excellent yields.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00506G, Paper
Supramolecular pKa shift and fluorescence quenching in a neutral red dye in the presence of p-sulfonatocalix[4/6]arenes have been demonstrated, which are relevant for the off–on switch, ion sensitive electrodes and drug delivery vehicles.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00795G, Communication
A mild protocol for regioselective alkyne dithioacetalization using nonthiolic and odorless 2-chloro-dithiane has been developed.
Santikorn Chaimanee, Manat Pohmakotr, Chutima Kuhakarn, Vichai Reutrakul and Darunee Soorukram
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00749C, Paper
The first asymmetric synthesis of ent-fragransin C1 bearing 2,3-anti-3,4-syn-4,5-anti stereochemistries is reported.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00468K, Review Article
An overview on the development of unique methodologies that highlight the use of AlCl3 in reactions leading to new N-heteroarenes of biological significance is presented.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00578D, Paper
An efficient synthetic pathway to 1,3-diene-2-ol sulfonates involving the [3,3]-sigmatropic rearrangement of allenic alcohols with sulfonic acids under mild reaction conditions is described.
Qiang Fei, Xianfeng Gu, Yajing Liu, Ben Shi, Hengyan Liu, Ge Xu, Chunbao Li, Ping Shi and Chunchang Zhao
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00383H, Communication
New ESIPT-based BODIPYs are developed to render the NIR emissions with a large Stokes shift.
Haojiang Wang, Yifeng Wang, Cheng Zhang, Yidong Jiang, Mingming Chu, Zhaobo Li, Xiaohua Du and Danqian Xu
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00677B, Paper
A highly enantioselective conjugate addition of 2-substituted benzofuran-3(2H)-ones to α,β-unsaturated ketones promoted by chiral copper complexes has been developed.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00640C, Paper
A lanthanide-catalyzed one-pot reaction using readily accessible substrates was developed affording spiro[cyclopropan-1,3′-oxindoles] in good yields and with high stereoselectivity.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00686A, Review Article
Protein assembly is important in nature and bionics. Herein, we have reviewed the recent progress in protein assemblies induced by cucurbituril-based supramolecular interactions and their applications.
Chu-Han Sun, Yi Lu, Qing Zhang, Rong Lu, Lin-Qing Bao, Mei-Hua Shen and Hua-Dong Xu
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00040E, Communication
Arynes enable highly selective S-arylation and N-arylation.
Benedetta Bertolotti, Ieva Sutkeviciute, Martino Ambrosini, Renato Ribeiro-Viana, Javier Rojo, Franck Fieschi, Hana Dvořáková, Martina Kašáková, Kamil Parkan, Martina Hlaváčková, Kateřina Nováková and Jitka Moravcová
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00322F, Paper
New multivalent glycomimetics are synthesized to interact efficiently with the promising target DC-SIGN.
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31 citations
A unified strategy for the palladium-catalyzed Suzuki–Miyaura cross-coupling of amides with boronic acids for the synthesis of ketones by N–C bond activation is reported.
DOI: 10.1039/C6OB00084C
Published: 11 Feb 2016
61 citations
The recent advances in the copper-catalysed azide–alkyne cycloaddition (CuAAC) reactions are reviewed.
DOI: 10.1039/C5OB01457C
Published: 31 Jul 2015
58 citations
This review article covers the main types of gold(i) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.
DOI: 10.1039/C5OB00736D
Published: 19 May 2015

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