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Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

Organic synthesis, supramolecular chemistry, chemical biology and more.
On average get a first decision in 12 days for Communications and 18 days for Papers.
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Haigen Fu, Sabry Younes, Mohammad Saifuddin, Pieter Tepper, Jielin Zhang, Erik Keller, André Heeres, Wiktor Szymanski and Gerrit J Poelarends
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00305F, Communication
The complex amino acid (L-threo)-3-[3-[4-(trifluoromethyl)benzoylamino] benzyloxy]aspartate (L-TFB-TBOA) and its derivatives are privileged compounds for studying the roles of excitatory amino acid transporters (EAATs) in regulation of glutamatergic neurotransmission, animal behavior,...
Marta Meazza, Hao Guo and Ramon Rios
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C6OB02647H, Review Article
Vinyl cyclopropanes are amongst the most usefuls building blocks in organic synthesis. Their easy opening and capacity to generate dipoles have been exploited for the synthesis of cyclopentanes with good...
Jieru Yang, Xiaofan Zhou, Yu Zeng, Chaoqian Huang, Yuanjing Xiao and Junliang Zhang
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C6OB02749K, Paper
A simple base mediated reaction of 2-trifluoromethyl-1,3-conjugated enynes with N-acetylated 2-Aminomalonates was developed, which could deliver two distinct types of products depending on substrates, i. e. 4-trifluoromethyl pyrrolidines derivatives, or...
Rodney Agustinho Fernandes, Pullaiah Kattanguru, Sachin P Gholap and Dipali Arun Chaudhari
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C6OB02625G, Review Article
In the past decade, the Overman rearrangement, an important C-N bond forming reaction has been intensely used in the synthesis of natural products, synthetic intermediates, building blocks and valuable compounds....
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02674E, Paper
A reliable post-synthetic method to access the modified RNA oligomers containing biologically important 5-methyluridines: mnm5U, cmnm5U, τm5U, nm5U, inm5U and cnm5U.
Gopalaiah Kovuru, Anupama Saini, Sankala Naga Chandrudu, Chenna Rao Devarapalli, Harsh Yadav and Binay Kumar
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00122C, Paper
A copper-catalyzed oxidative coupling reaction of o-phenylenediamines with 2-aryl/heteroarylethylamines using molecular oxygen as an oxidant has been developed. This novel approach provides a practical and direct access to construct quinoxalines...
Ethan J Linstad, Amy Vavere, Bao Hu, Jayson J Kempinger, Scott E Snyder and Stephen G DiMagno
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00253J, Paper
Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in...
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00341B, Paper
The efficient synthesis of 2-aryloxy-3-butenoic acid esters by the allylic C-H bond carboxylation of allyl aryl ethers with CO2 has been achieved through the deprotonative alumination with an aluminium ate...
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C6OB02792J, Communication
The T4 DNA ligase-catalysed oligonucleotide polymerisation process has been recently developed to enable the incorporation of multiple functional groups throughout a nucleic acid polymer. T4 DNA ligase requires ATP as...
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00112F, Communication
Un-protected 2-acetamido terminated reducing sugars may be converted into the corresponding glycosyl thiols in water, and conjugated to peptides using the thiol–ene click reaction without recourse to any protecting groups.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00078B, Paper
One pot novel synthesis of highly functionalized polyarylphenols via benzannulation under transition-metal-free conditions and their antioxidant activities are described.
Chiara Zanato, Alessia Pelagalli, Katie F. M. Marwick, Monica Piras, Sergio Dall'Angelo, Andrea Spinaci, Roger G. Pertwee, David J. A. Wyllie, Giles E. Hardingham and Matteo Zanda
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02796B, Paper
Prospective PET tracers HU-210F and HU-211F were synthesised and tested as ligands of cannabinoid (CB1 and CB2) and N-methyl D-aspartate (NMDAR) receptors.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02773C, Paper
Synthesis of a novel 3′-pyrene-functionalized UNA monomer with unprecedented thermal stabilization of duplexes and triplexes.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00140A, Paper
A facile access to α-fluoro-β-hydroxyketones via electrophilic fluorination.
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00113D, Review Article
The organocatalytic reduction of C=C and C=N double bonds with biomimetic reductants, e.g. Hantzsch 1,4-dihydropyridine esters and benzothiazolines, is reviewed. Very high yields and stereoselectivities have been achieved with a...
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00259A, Communication
Deletion of the biosynthetic 4,6-dehydratase gene, jadT, present in the angucycline jadomycin dideoxysugar biosynthetic pathway, led to the isolation of a novel C12 glucosylated jadomycin. JadS was identified as the...
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00364A, Paper
We report the synthesis of a zwitterionic indenylammonium compound and its carbon-centred reactivity toward reversible CO2 binding through the formal insertion into a C−H bond as well as catalytic hydroboration...
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00009J, Paper
A Co(II)-catalyzed carbocyclization reaction for the synthesis of 4-substituted quinolin-2-(1H)-ones is described.
Shashidhar Nizalapur, Onder Kimyon, Eugene Yee, Kitty Ho, Thomas Berry, Mike Manefield, Charles G. Cranfield, Mark Willcox, David StC Black and Naresh Kumar
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00053G, Paper
Novel antibacterial peptidomimetics that inhibit the growth of planktonic cells and reduce biofilm formation in both Gram-positive and Gram-negative bacteria.
Shigeyuki Yamada, Keita Kinoshita, Shota Iwama, Takashi Yamazaki, Toshio Kubota, Tomoko Yajima, Kyoko Yamamoto and Shinya Tahara
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00043J, Paper
Symmetrical and unsymmetrical pentacenes carrying two perfluoroalkyl (Rf) chains at 6 and 13 position were synthesized from easily available pentacene-6,13-quinone via facile three or four step reactions. After their extensive...
Yu Zhang, Xiangfeng Guo, Mengmeng Zheng, Rui Yang, Hongming Yang, Lihua Jia and Mengmeng Yang
Org. Biomol. Chem., 2017, Accepted Manuscript
DOI: 10.1039/C7OB00201G, Paper
A 4,5-quinolimide derivative BNA bearing the amide-DPA receptor was synthesized as a turn-on fluorescent sensor for Cd2+. Under physiological conditions, BNA could distinguish Cd2+ from Zn2+, showing the turn-on fluorescence...
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00222J, Review Article
A review of computational studies of the related biosyntheses of steroids and hopenes reported during the last two decades is presented.
Jakub Szyling, Adrian Franczyk, Piotr Pawluć, Bogdan Marciniec and Jędrzej Walkowiak
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00054E, Paper
A new highly selective method for the synthesis of (E)-arylvinyl iodides and (E)- or (Z)-β-arylvinyl bromides from easily accessible styrenes and vinyl boronates, on the basis of a one-pot procedure via borylative coupling/halodeborylation is reported.
Subrata Mukherjee, Sumi Joseph, Anup Bhunia, Rajesh G. Gonnade, Santhivardhana Reddy Yetra and Akkattu T. Biju
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB00148G, Paper
The NHC-catalyzed enantioselective, oxidative formal [3 + 2] annulation of α,β-unsaturated aldehydes with 3-hydroxy oxindoles is presented.
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C7OB90028G, Correction
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24 citations
A unified strategy for the palladium-catalyzed Suzuki–Miyaura cross-coupling of amides with boronic acids for the synthesis of ketones by N–C bond activation is reported.
DOI: 10.1039/C6OB00084C
Published: 11 Feb 2016
57 citations
The recent advances in the copper-catalysed azide–alkyne cycloaddition (CuAAC) reactions are reviewed.
DOI: 10.1039/C5OB01457C
Published: 31 Jul 2015
53 citations
This review article covers the main types of gold(i) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.
DOI: 10.1039/C5OB00736D
Published: 19 May 2015

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