Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
 
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Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02160F, Paper
A simple method for direct metal-free C–H amination of unactivated hydrocarbons using easy-handling diacetoxy-λ3-bromane and triflylamide or sulfamate esters was developed.
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02217C, Communication
Dynamic covalent crosslinking approach is used to crosslink supramolecular peptide gels. This novel approach facilitates tuning viscoelastic properties of the gel and enhances mechanical stability (storage modulus exceeding 105 Pa)...
 
Christoffer Karlsson, Magnus Blom, Miranda Johansson, Anna M Jansson, Enzo Scifo, Anders Karlén, Thavendran Govender and Adolf Gogoll
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01926A, Paper
Incorporation of an artificial amino acid 2 with a stilbene chromophore into peptidomimetics with three to nine amino acids yields phototriggerable candidates for inhibition of the binding between the R1...
 
David C. McCutcheon, William B. Porterfield and Jennifer A. Prescher
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02529F, Paper
Improved access to luciferins will bolster bioluminescence imaging applications.
 
Enrico La Cascia, Xavier Sanz, Carles Bo, Andrew Whiting and Elena Fernandez
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02478H, Communication
The adduct [MeO → Bpin–Bpin] efficiently mediates the β-boration of α,β-unsaturated imines formed in situ.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02254H, Review Article
Group-assisted purification (GAP) chemistry, which can provide various chiral amines and other functionalities without the use of column chromatography or recrystallization; products are consistently obtained with excellent stereocontrol.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02531H, Paper
Both heat shock protein 90 and 70 (Hsp90, Hsp70) are cytoprotective proteins that regulate cell function and faciliate cell growth by stabilizing and folding proteins.
 
Cheng-Kun Lin, Li-Wei Cheng, Huang-Yi Li, Wen-Yi Yun and Wei-Chieh Cheng
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01934B, Paper
A straightforward synthesis of novel, 2-heterocyclyl polyhydroxylated pyrrolidines is described.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02220C, Paper
A Sc(OTf)3-catalyzed and air-mediated cascade reaction was discovered as an efficient approach to the novel fluorescent fused-four-ring dibenzo[b,h][1,6]naphthyridine derivatives.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02171A, Review Article
This review summarizes synthetic methods for directing group guided, transition metal catalyzed meta-C–H functionalization of aromatic compounds.
 
Alexander S. Bogachenkov, Albina V. Dogadina, Vadim P. Boyarskiy and Aleksander V. Vasilyev
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02269F, Communication
1-(Diphenylphosphoryl)alka-1,2-dienes in acids (TfOH, FSO3H, H2SO4) give (3-hydroxyalk-1-en-1-yl)diphenylphosphine oxides, that are further converted into 1-phenyl-1,4-dihydrophosphinoline 1-oxides. The latter compounds are directly formed from these 1,2-dienes under the action of AlCl3.
 
Shiue-Shien Weng, Wen-Chieh Yang, Ananthan Ramasamy, Gobi Rajeshwaren, Yi-Ya Liao and Chien-Tien Chen
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02621G, Paper
A series of oxometallic species and metal acetylacetonates (acac) was examined as catalysts for oxidative carbonylation of styrene with benzaldehyde by using t-butylhydroperoxide as co-oxidant in warm acetonitrile. Among them,...
 
Weitao Gong, Duo Na, Le Fang, Hassan Mehdi and Guiling Ning
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02498B, Communication
Gemini surfactant-like receptor R1 is designed and synthesized. The special preassembly phenomenon of R1 in nonpolar solvent facilitate the novel ratiometric fluorescence sensing of H2PO4- via anion-induced reassembly process in...
 
Xiang Li, Suyan Sun, Fan Yang, Jianxun Kang, Yusheng Wu and Yangjie Wu
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02410A, Paper
An efficient and general applicable protocol for palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with dialkyl H-phosphonates has been developed. This methodology provides a new and practical route to alkynylphosphonates using...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02212B, Paper
The ability to specifically engineer metal binding sites into target proteins has far-reaching consequences ranging from the development of new biocatalysts and imaging reagents to the production of proteins with...
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02535K, Paper
A regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an enzyme-responsive functionality, depending on the protease activity was constructed.
 
Qi Yan, Brigitte F. Schmidt, Lydia A. Perkins, Matharishwan Naganbabu, Saumya Saurabh, Susan K. Andreko and Marcel P. Bruchez
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02309A, Paper
A bis-sulfonate linker modified malachite green fluorogen improves its specificity and allows rapid, no-wash labeling of receptors on living cells.
 
Matthias Winkler, Marjorie Maynadier, Sharon Wein, Marie-Ange Lespinasse, Giovanna Boumis, Adriana E. Miele, Henri Vial and Yung-Sing Wong
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02459A, Paper
An expedient synthesis of aculeatin-like analogues results in finding PfTrxR as putative cellular target and a promising new antimalarial chemotype.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02343A, Paper
An efficient and regioselective copper(II)-catalyzed coupling reaction of N′-aryl acylhydrazines for the synthesis of N′,N′-diaryl acylhydrazines has been developed.
 
Mariëlle M. E. Delville, Kaspar Koch, Jan C. M. van Hest and Floris P. J. T. Rutjes
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02128B, Communication
From themed collection Recent Advances in Flow Synthesis and Continuous Processing
Integrated two-step chemoenzymatic continuous flow process for the synthesis of protected cyanohydrins from aldehydes.
 
Marc Y. Stevens, Krzysztof Wieckowski, Peng Wu, Rajiv T. Sawant and Luke R. Odell
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02417F, Paper
A series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a novel cascade imine/cyclization/aza-Henry reaction in moderate to excellent yields.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02340D, Paper
The elimination of HCl and CO2 in the corresponding cycloadducts makes the unfavourable polar Diels–Alder reaction of 3-chloroindole irreversible.
 
Artur J. Moro, Bertrand Rome, Elisabet Aguiló, Julià Arcau, Rakesh Puttreddy, Kari Rissanen, João Carlos Lima and Laura Rodríguez
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02077D, Paper
A phosphine-gold(I)-alkynyl-coumarin complex, [Au{7-(prop-2-ine-1-yloxy)-1-benzopyran-2-one}(DAPTA)] (1), was synthesized and the formation of long luminescent fibers in solution was characterized via fluorescence microscopy and dynamic light scattering.
 
Gowri Priya, Amol S. Kotmale, Debamitra Chakravarty, Vedavati G. Puranik, Pattuparambil R. Rajamohanan and Gangadhar J. Sanjayan
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02421D, Paper
This communication describes the utility of the conformationally restricted aromatic β-amino acid (2-aminobenzenesulfonic acid, SAnt) for inducing various folding interactions in short peptides.
 
Mathias Pichler, Johanna Novacek, Raphaël Robiette, Vanessa Poscher, Markus Himmelsbach, Uwe Monkowius, Norbert Müller and Mario Waser
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02318H, Paper
Phenylglycinol serves as a powerful chiral auxiliary in ammonium ylide-mediated reactions to obtain chiral epoxides/aziridines with excellent stereoselectivities.
 
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