Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.568 48 Issues per Year Indexed in MEDLINE
 
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Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00245H, Paper
1,2,4,5-Tetrazine fluorophore derivatives with structurally rigid molecular designs were synthesized using Sonogashira and Stille cross-coupling as well as copper-catalyzed azide alkyne cycloaddition. The synthesized bichromophoric systems exhibit low fluorescence quantum...
 
Patrick C. Schmartz, Katja Zerbe, Khaled Abou-Hadeed and John A. Robinson
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00474D, Communication
The vancomycin biosynthetic halogenase can bis-chlorinate both β-hydroxytyrosine residues-2 and -6 in a model substrate comprising a PCP-linked hexapeptide.
 
Martin Ipuy, Cyrielle Billon, Guillaume Micouin, Jacques Samarut, Chantal Andraud and Yann Bretonnière
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00147H, Paper
Fluorophores displaying a sensitive response to pH are reported. Structural variations allow fine tuning of pKa and ratiometric intracellular pH imaging.
 
Romain Veillard, Elise Bernoud, Ibrahim Abdellah, Jean-François Lohier, Carole Alayrac and Annie-Claude Gaumont
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00397G, Paper
A versatile synthesis of P-stereogenic 1,2,3-triazolyl-4-phosphines from the borane complexes of phosphino-alkynes has been developed.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00200H, Paper
A novel total synthesis of (S)-tylophorine is reported, featuring asymmetric allylation and cascade isocyanate formation and cyclization.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00332B, Review Article
Recent progress towards catalytic, enantioselective vinylogous Michael reactions is presented which deliver optically highly enriched 1,7-dioxo compounds of great utility in organic synthesis.
 
Dindyal Mandal, Amir Nasrolahi Shirazi and Keykavous Parang
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00447G, Review Article
The formation of well-ordered nanostructures through self-assembly of diverse organic and inorganic building blocks has drawn much attention owing to their potential applications in biology and chemistry.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00437J, Communication
A simple and efficient methodology has been developed for the synthesis of pyrrolobenzoxazine and 3-arylamino coumarin derivatives promoted by trifluoroacetic acid. The initial step in the current protocol involves a Michael addition of the 1,4-benzoxazinone derivatives to the Michael acceptors and subsequent cyclization.
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00318G, Review Article
Environmentally friendly hypervalent iodine reagents are unusually effective promoters of asymmetric α-functionalization of carbonyl compounds. By using hypervalent iodine reagents, various substituents can be introduced into the α-position of carbonyl...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C3OB42517G, Paper
Glycine, as a kind of commercially available and inexpensive ligand, is used to prepare an air-stable and water-soluble catalyst used in Suzuki-Miyaura reaction in our study. In the presence of...
 
liangxian Liu, Wen-Bing Qin, Jia-yi Zhu, Yu-bo Kong, Yun-hong Bao and Zhengwang Chen
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00356J, Paper
Direct metal-free C-4-selective indolation of pyridines is achieved for the first time using TEMPO and (Boc)2O. A variety of substituents on both indoles and pyridines are tolerated to give 3-(pyridin-4-yl)-1H-indole...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00475B, Paper
A transition-metal-free process for the synthesis of 1,4-dihydroquinoline derivatives starting from simple enaminones with aldehydes via intermolecular cascade cyclization in one-pot protocol is developed. This methodology affords a variety of...
 
A. R. Cochrane, C. Idziak, W. J. Kerr, B. Mondal, L. C. Paterson, T. Tuttle, S. Andersson and G. N. Nilsson
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00465E, Paper
The use of alternative solvents in the iridium-catalysed hydrogen isotope exchange reaction with developing phosphine/NHC Ir(I) complexes has identified reaction media which are more widely applicable than the commonly employed chlorinated solvent, dichloromethane.
 
Jonathan K. W. Chui and T. M. Fyles
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00480A, Paper
Cyclodextrin ion channels, assembled by click chemistry, exhibit mechanistically diverse behaviors including transient blockage by hydrophobic guests.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00155A, Paper
Copper-catalyzed direct olefination of benzaldehydes into unsymmetrical 1,3-diarylpropenes by a novel domino Knoevenagel-decarboxylation-Csp3-H activation sequence using simpler substrates like benzaldehydes.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00443D, Communication
N-Galactosyl aziridines were synthesized, and the ring-opening reactions provided enantiometrically pure β-S-substituted phenylalanine derivatives with high regioselectivity.
 
Bao-Quan Liu, Wen-Jing Yi, Ji Zhang, Qiang Liu, Yan-Hong Liu, Sheng-Di Fan and Xiao-Qi Yu
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00384E, Paper
Novel cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails were synthesized and applied as non-viral gene vectors.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00323C, Communication
A facile stereoselective approach has been developed for the total synthesis of cytospolide P via Yamaguchi macrolactonization.
 
Binglian Bai, Jie Ma, Jue Wei, Jianxi Song, Haitao Wang and Min Li
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00056K, Paper
The C8 organogel could show reversible gel–sol transition and color changes by the use of F stimuli and proton control.
 
Rômulo F. S. Canto, Flavio A. R. Barbosa, Vanessa Nascimento, Aldo S. de Oliveira, Inês M. C. Brighente and Antonio Luiz Braga
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00598H, Paper
We report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease.
 
Mohammed Ikbal, Biswajit Saha, Shrabani Barman, Sanghamitra Atta, Deb Ranjan Banerjee, Sudip Kumar Ghosh and N. D. Pradeep Singh
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C3OB42600A, Paper
(Benzo[a]acridin-12-yl)methyl (BAM) chromophore has been shown to perform dual functions as a “pH sensitive fluorescent probe” and a “phototrigger” for acids.
 
Hai-Xia Jiang, Dao-Min Zhuang, Ying Huang, Xing-Xin Cao, Jian-Hua Yao, Jing-Yun Li, Jian-Yong Wang, Chen Zhang and Biao Jiang
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C3OB42186D, Paper
A novel series of trifluoromethyl indoles have been designed, synthesized and evaluated for anti-HIV-1 activities.
 
Jian-Peng Yin, Chun-Lan Tang, Li-Xin Gao, Wei-Ping Ma, Jing-Ya Li, Ying Li, Jia Li and Fa-Jun Nan
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00214H, Paper
Paracaseolide A analogues showed improved PTP1B enzyme inhibitory activity, high selectivity for PTP1B over TC-PTP, and improved cellular effects.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00094C, Paper
A novel and regioselective approach to synthesize anticancer 4,5-diaryl functionalized 3,4-dihydropyrimidine-2(1H)-thiones is described.
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00080C, Paper
The N[1,3]-sigmatropic shift in the benzidine rearrangement has been studied in depth experimentally with the aid of the density functional theory (DFT) calculations. The designed substituted N,N’-diaryl hydrazines rearrange exclusively...
 
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