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Organic & Biomolecular Chemistry

Rapid publication of high quality organic chemistry research
 
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Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02566H, Paper
A novel electronic halocyclization and radical haloazidation of benzene-linked 1,7-dienes for the formation of functionalized 3,1-benzoxazines has been achieved by using TMSN3 as an azido source and NBS as a...
 
Jesús M. de los Santos, Gloria Rubiales, Zouhair Es Sbai, Ana M. Ochoa de Retana and Francisco Palacios
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02486F, Paper
The behavior of phosphinyl nitrosoalkenes with indole, pyrrole and 2,5-dimethylpyrrole is described. The reaction of nitrosoalkenes with indole leads to the formation of 3-substituted indoles. While a concerted asynchronous [4+2]...
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02412B, Paper
The synthesis of sialic acids and their analogs was accomplished based on substrate-controlled asymmetric aldol reactions between sterically complicated aldehydes easily prepared from commercially available carbohydrates and a novel pyruvic...
 
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02461K, Communication
Visible-light-promoted radical cyclization of disulfides and alkynes provided benzothiophenes in good yields.
 
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02364A, Communication
Novel and efficient synthesis of S-aryl/alkyl phosphinothioates from P(O)–H and aryl/alkyl sulfonyl chlorides under metal- and base-free conditions is described.
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02523D, Paper
A diastereoselective approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones 1 (P1=TBS, P2=H) has been developed through stereoselective tandem Barbier process of (R,SRS)-8 with alkyl and aryl bromide. The stereochemistry at the C-5 stereogenic...
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02306A, Paper
The proline analogue (2S,3aS,7aS)-octahydroindole-2-carboxylic acid (Oic) has been previously applied as a proline substitute in pharmocologically active peptides and as a structural component of the antihypertensive drug Perindopril. Herein, we...
 
Lilya U. Dzhemileva, Vladimir A. D'yakonov, Aleksey A. Makarov, Evgeny N. Andreev, Milyausha M. Yunusbaeva and Usein M. Dzhemilev
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02346K, Paper
The first gram-scale total synthesis of natural lembehyne B, a selective inducer of early apoptosis in leukemia cancer cells, has been developed.
 
Yixiang Jiang, Kuan Hu, Xiaodong Shi, Qingzhuang Tang, ZiChen Wang, Xiyang Ye and Zigang Li
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02289H, Communication
Different in-tether chiral centres show distinguishable properties, proving in-tether chiral centres are a valuable modification site for constructing peptide ligands.
 
Hongxiang Wu, Tingting Liu, Ming Cui, Yue Li, Junsheng Jian, Hui Wang and Zhuo Zeng
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02526A, Communication
The first rhodium-catalyzed C–H functionalization with N-acylsaccharins by decarbonylation has been developed and afforded biaryls in 51–93% yields.
 
Omayra H. Rubio, Rachid Taouil, Francisco M. Muñiz, Laura M. Monleón, Luis Simón, Francisca Sanz and Joaquín R. Morán
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02237E, Paper
A new chiral chromane receptor has been synthesized with a right-sized oxyanion hole to fix zwitterionic alanine. This associate allows the enantioselective extraction of this amino acid from water to chloroform.
 
Chengcai Xia, Kai Wang, Jun Xu, Chao Shen, Di Sun, Hongshuang Li, Guodong Wang and Pengfei Zhang
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02375D, Communication
The remote C–O coupling of quinoline amides at the C5 position has been established using cheap and readily available copper catalyst under mild conditions.
 
Hong Li, Ruilong Zhang, Chunxia Li, Bei Huang, Tingting Yu, Xiaodan Huang, Xuanjun Zhang, Fei Li, Hongping Zhou and Yupeng Tian
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02384C, Paper
L displays high selectivity for Cu2+ with a rapidly reversible on–off–on fluorescence switch.
 
Hui Zhao, Yanhong Jiang, Yuan Tian, Dan Yang, Xuan Qin and Zigang Li
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02501C, Paper
Physicochemical properties including hydrophobicity and isoelectric point are the driving forces for cellular uptake and nucleus translocation of stabilized helices.
 
Jialing Cai, Shuo Huang, Ruenfa He, Lu Chen, Donghan Chen, Shaohua Jiang, Bin Li and Yibiao Li
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02351G, Communication
Thienopyridines and related heterocycles were prepared by a reagent-capsule-assisted palladium-catalyzed cross-coupling, thiolation and cyclization process in moderate to good yields.
 
Gabriela G. Gerosa, Nicolás Grimblat, Rolando A. Spanevello, Alejandra G. Suárez and Ariel M. Sarotti
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02457B, Paper
The mechanism of the acid-catalyzed isomerization of polysubstituted pyrrolidines was unravelled by a combination of experimental, spectroscopic and computational studies.
 
Alexandre Murza, Xavier Sainsily, Jérôme Côté, Laurent Bruneau-Cossette, Élie Besserer-Offroy, Jean-Michel Longpré, Richard Leduc, Robert Dumaine, Olivier Lesur, Mannix Auger-Messier, Philippe Sarret and Éric Marsault
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02247B, Paper
Apelin is the endogenous ligand for the G protein-coupled receptor APJ and exerts a key role in regulating cardiovascular functions.
 
Weili Shen, Qing Liu, Baoquan Ding, Changqing Zhu, Zhiyong Shen and Nadrian C. Seeman
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02281B, Paper
Overwound and underwound paranemic crossover (PX) DNA motifs have been self-assembled to generate high uniformity lattices, by adjusting the number of base pairs in the JX region adjacent to the PX structure to relieve torsional strain.
 
Roberto Villar López, Olalla Nieto Faza, Eduard Matito and Carlos Silva López
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02288J, Paper
Very recently, the CO2 trimer has been experimentally synthesized, isolated and characterized.
 
José A. González-Delgado, Miguel A. Romero, Uwe Pischel and Jesús F. Arteaga
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02587K, Paper
Efficient few-step asymmetric synthesis of tectoionol B, a representative member of the megastigmane family, starting from geranylacetone via ZrCl4-mediated selective formation of the highly substituted cyclohexene skeleton.
 
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02057G, Paper
The α-ketoacid-hydroxylamine amide-forming (KAHA) ligation reactions were investigated using computational methods to provide improved insights on the mechanism of these reactions.
 
Arghya Banerjee, Satavisha Sarkar and Bhisma K. Patel
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB01975G, Review Article
This review demonstrates strategies for the directed and non-directed Csp3–H bond functionalisation of cycloalkanes leading to the formation of C–C and C–X bonds.
 
Zhongfu Deng, Xiangjun Peng, Panpan Huang, Lili Jiang, Dongnai Ye and Liangxian Liu
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02285E, Paper
A method for combinative oxidative homo dimerization and cyanomethylation of free indole derivatives catalysed by TEMPO and Pd(OAc)2 was demonstrated for the first time.
 
Org. Biomol. Chem., 2017, Advance Article
DOI: 10.1039/C6OB02240E, Paper
para-Nitrophenyl α2–8-sialosides containing different sialic acid forms were chemoenzymatically synthesized and used as effective probes for high-throughput substrate specificity studies of the α2–8-sialidase activities of human and bacterial sialidases.
 
Jan Cvengros, Raul Pereira, Lukas Pfeifer, Jean Fournier and Veronique Gouverneur
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02359B, Paper
The typically planar amide when incorporated in bicyclic systems can undergo a significant distortion from planarity resulting in physical properties and reactivity that deviate from classical amide behaviour. Herein, we...
 
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77 citations
Donor–acceptor cyclopropane annulations – not just for heterocycles.
DOI: 10.1039/C4OB02117G
Published: 13 Nov 2014
45 citations
This review article covers the main types of gold(i) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.
DOI: 10.1039/C5OB00736D
Published: 19 May 2015
46 citations
The recent advances in the copper-catalysed azide–alkyne cycloaddition (CuAAC) reactions are reviewed.
DOI: 10.1039/C5OB01457C
Published: 31 Jul 2015

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