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Organic & Biomolecular Chemistry

Rapid publication of high quality organic chemistry research
Impact Factor 3.562 48 Issues per Year Indexed in Medline
 
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Sajita Shah, Chaemin Lee, Hyukjae Choi, Jaya Gautam, Hyeonjin Jang, Geum Jin Kim, Yu-Jeong Lee, Chhabi Lal Chaudhary, Sang Won Park, Tae-gyu Nam, Jung-Ae Kim and Byeong-Seon Jeong
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00406G, Paper
Synthesis of a series of hybrid compounds of pyridinol and sunitinib and their cytotoxicity against human cancer cell lines and improved safety windows are described.
 
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00901H, Paper
Synthesis of isoquinolines based on efficient C–C and C–N bond formation through Rh(III)-catalyzed C–H functionalization and subsequent intramolecular cyclization is reported. Diazodiesters serving as a C2 source in the newly formed heterocycles are first demonstrated.
 
Rajdip Karmakar, Kung-Pern Wang, Sang Young Yun, Phani Mamidipalli and Daesung Lee
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00524A, Communication
A new functionalization method of arynes promoted by a novel catalytic role of the Grubbs-type ruthenium alkylidene complex is described.
 
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00655H, Paper
The first total synthesis of the proposed and authentic structures of camellianin B were achieved, based on which the chemical structures of camellianins A and B were revised.
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00577B, Paper
Substituted N-tert-butoxycarbonyl (Boc)-1,2,3,4-tetrahydroisoquinolines were prepared and treated with n-butyllithium in THF at –50 °C to test the scope of the metallation and electrophilic quench. The lithiation was optimised by using...
 
Hemi Cumming, Sarah Louise Brown, Tao Xu, Claire Cuyamendous, Jessica J Field, John H Miller, Joanne Harvey and Paul Teesdale-Spittle
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00086J, Paper
Pateamine A is a naturally occurring metabolite extracted from the marine sponge Mycale hentscheli. It exhibits potent cytotoxicity towards cancer cell lines and has been shown to target protein translation...
 
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00535G, Paper
Liposomes composed of unsaturated lipids were more stable than those containing saturated lipids toward DMe-β-CDx, DMe-α-CDx and DMe-β-CDx. The Hill coefficient values (n) indicated that the saturated lipid•DMe-CDx complexes had...
 
Chad N. Ungarean, Emma H. Southgate and David Sarlah
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00375C, Review Article
From themed collection New Talent
A comprehensive review covering the field of enantioselective polyene cyclizations.
 
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00882H, Paper
We report a strategy for site-specific protein ubiquitination using dehydroalanine (Dha) chemistry for the preparation of ubiquitin conjugates bearing a very close mimic of the native isopeptide bond.
 
Niek Eisink, Jonas Lohse, Martin Witte and Adriaan J Minnaard
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00608F, Paper
Palladium-catalyzed alcohol oxidation allows the chemo- and regioselective modification of unprotected 1-4 linked glucans. This is demonstrated in the two-step bisfunctionalization of 1-4 linked glucans up to the 7-mer. Introduction...
 
Milandip Karak, Luiz Claudio Almeida Barbosa, Jaime Alejandro M Acosta, Ariel Marcelo Sarotti and John Boukouvalas
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00895J, Paper
A stereoselective vinylogous aldol reaction of N-monosubstituted tetronamides with aldehydes is described. The procedure is simple and scalable, works well with both aromatic and aliphatic aldehydes, and affords mainly the...
 
Shyam K. Konda, Celine Kelso, Paul P. Pumuye, Jelena Medan, Brad E. Sleebs, Suzanne M. Cutts, Don R. Phillips and J. Grant Collins
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00561F, Paper
The ability of the anthracenedione anticancer drug WEHI-150 to form covalent adducts with DNA, after activation by formaldehyde, has been studied by mass spectrometry, HPLC and NMR spectroscopy.
 
Rachel K. Chambers, Tanweer A. Khan, David B. Olsen and Brad E. Sleebs
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C5OB01842K, Review Article
Synthetic strategies to access 2-amino heterocycle head groups that inhibit aspartyl proteases, are reviewed.
 
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00685J, Paper
A systematic optimization of a Pd-catalyzed enantioselective borylative migration of an alkenyl nonaflate derivative of the simple precursor, N-Boc-4-piperidone, was achieved.
 
Victoria K. Kensy, Gregory I. Peterson, Derek C. Church, Neal A. Yakelis and Andrew J. Boydston
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00400H, Communication
From themed collection New Talent
We have investigated the dynamic nature of 1,2-oxazines, which revealed broad tunability and potential for applications in covalent adaptable materials.
 
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00676K, Paper
The palladium-catalyzed decarboxylative amidation of α-oxocarboxylic acids with secondary amides was developed under mild reaction conditions.
 
Lenka Kubovičová, Kristýna Bürglová and Jan Hlaváč
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00737F, Paper
An efficient method for removal of the hydrazine group from (hetero)aromatic substrates has been developed.
 
Akira Yoshimura, Mekhman S. Yusubov and Viktor V. Zhdankin
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00773B, Review Article
In this review the preparation and structural features of pseudocyclic iodine(III) and iodine(V) derivatives are discussed, and recent developments in their synthetic applications are summarized.
 
Giacomo E. M. Crisenza, Elizabeth M. Dauncey and John F. Bower
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00705H, Paper
From themed collection New Talent
C2-alkenylated heteroaromatics can be accessed by simple Brønsted acid catalysed union of diverse heteroarene N-oxides with alkenes. The scope and limitations of the process are outlined.
 
Weitao Gong, Mehdi Hassan, Hongchang Pang, manivannan kalavathi dhinakaran, wajahat Ali, Xiaojun Kuang and Guiling Ning
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00600K, Paper
A novel smart supramolecular organic gelator G-16 containing anion and metal-coordination ability has been designed and synthesized. It shows excellent and robust gelation capability as a strong blue fluorescent supramolecular...
 
Hong-Yao Wang, Atsushi Kato, Kyoko Kinami, Yi-Xian Li, George W J Fleet and Chu-Yi Yu
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00697C, Paper
The key step in the concise syntheses of calystegine B2 and its C-2 epimer calystegine B3 was the construction of the cycloheptanone 8 via an intramolecular Nozaki–Hiyama–Kishi (NHK) reaction of...
 
Frédérique Deiss, Yang Yang, Wadim Matochko and Ratmir Derda
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB00898D, Paper
In this report, we describe the methodology for 96 parallel organic syntheses of peptides on Teflon-patterned paper assisted by heating with an infra-red lamp. SPOT synthesis is an important technology...
 
Angie D. Calderon, Yunpeng Liu, Xu Li, Xuan Wang, Xi Chen, Lei Li and Peng G. Wang
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB90066F, Correction
 
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00716C, Paper
We evaluate the ability of hexahistidine tags to recruit deoxyribozymes for covalently modifying peptides and proteins.
 
Lauren R. Yule, Rebekah L. Bower, Harveen Kaur, Renata Kowalczyk, Debbie L. Hay and Margaret. A. Brimble
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00850J, Paper
Synthetic clicked pramlintide glycomimetics maintained AMY1(a) activity and are expected to possess superior synthetic and pharmacokinetic properties than N-glycosylated analogues.
 
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