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Organic & Biomolecular Chemistry

Rapid publication of organic chemistry research
Impact Factor 3.562 48 Issues per Year Indexed in Medline
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Liping Zhu, Wei Wang, Haixu Zhao, Muye Xu, Seiichi Tada, Takanori Uzawa, Mingzhe Liu and Yoshihiro Ito
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01271F, Paper
A dual functional peptide was designed by combining in vitro selected catalytic and binding activities. For catalytic activity, we performed in vitro selection for a peptide aptamer binding to hemin...
Xabier Osteikoetxea, Barbara Sódar, Andrea Németh, Katalin Éva Szabó-Taylor, Krisztina Pálóczi, Krisztina V Vukman, Viola Tamási, Andrea Balogh, Ágnes Kittel, Éva Pállinger and Edit Buzás
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01451D, Paper
Extracellular vesicles (including exosomes, microvesicles and apoptotic bodies) are currently attracting rapidly increasing attention from various fields of biology due to their ability to carry complex information and act as...
Beatriz Angulo, José I. García, Clara I. Herrerías, José A. Mayoral and Ana C. Miñana
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01033K, Paper
Polytopic chiral ligands based on bis(oxazoline) motifs can be efficiently used to prepare recoverable catalytic systems for Henry reactions using a release–capture strategy.
Hubert Hřebabecký, Eliška Procházková, Michal Šála, Pavla Plačková, Eva Tloušťová, Ona Barauskas, Yu-Jen Lee, Yang Tian, Richard Mackman and Radim Nencka
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00987A, Paper
We prepared a novel series of conformationally restricted bicyclonucleosides and nucleotides.
Ahmed Kamal, S. M. Ali Hussaini, M. Lakshmi Sucharitha, Y. Poornachandra, Faria Sultana and C. Ganesh Kumar
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01353D, Paper
A series of nitrofuran-triazole congeners were synthesized that displayed excellent to appreciable antimicrobial and antibiofilm activities. Compound 9f inhibited CYP51, an enzyme involved in ergosterol biosynthesis in fungi.
Elena Fernandez, Jorge J. Carbó, Ana B Cuenca, Jessica Cid and Diego Garcia
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01523E, Paper
We have experimentally proved the unsymmetrical 1,1-diboration of diazo compounds, formed in situ from aldehydes and cyclic and non-cyclic ketones, in the absence of any transition metal complex. The heterolytic...
K. Ranjith Reddy, A. Siva Reddy, Devendra K. Dhaked, S. K. Rasheed, Anup Singh Pathania, Ravi Shankar, Fayaz Malik and Parthasarathi Das
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01295C, Paper
Various pyrano[2,3-c]carbazoles are synthesized in high yields over five steps from commercially available resorcinol. Palladium-catalyzed arylation remains a key step in this novel strategy. The versatility of this protocol has been demonstrated by the first total synthesis of naturally occurring carbazole clauraila C.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01388G, Paper
Graphene oxide modified with a fluorescent calix[4]arene showed a highly selective recognition for carbaryl.
Marina Fosso Yatchang, Harry LeVine, III, Keith D Green, Oleg Tsodikov and Sylvie Garneau-Tsodikova
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01478F, Paper
As the number of individuals affected with Alzheimer’s disease (AD) increases and the availability of drugs for AD treatment remains limited, the need to develop effective therapeutics for AD becomes...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01207D, Paper
Hydrophobic moieties like lipid membrane anchors are highly demanded modifications for nucleic acid oligomers. Membrane-anchor modified oligonucleotides are applicable in biomedicine leading to new delivery strategies as well as in...
Pedro J. Perez, Estela Haldón and M. Carmen Nicasio
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01457C, Review Article
The reaction of organic azides and alkynes catalysed by copper species represents the prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed azide-alkyne cycloaddition), discovered in 2002, has been...
Mohamed A. Ibrahim, Siva S Panda, Alexander Oliferenko, Polina V Oliferenko, AS Girgis, Mohamed Elagawany, F Z Küçükbay, Chandramukhi S Panda, Girinath G. Pillai, Ahmed Samir, Kaido Tämm, Charles Dennis Hall and Alan R Katritzky
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01400J, Paper
Novel, cyclic peptidomimetics were synthesized by facile acylation reactions using benzotriazole chemistry. Microbiological testing of the synthesized compounds revealed an exceptionally high activity against Candida albicans with a minimum inhibitory...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01484K, Communication
A concise and efficient approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives has been accomplished by a three-component reaction involving sulfonyl acetonitrile, an aromatic aldehyde, and 6-aminouracil. The method...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01265A, Paper
Lanthanide ions are strong Lewis acids. The complexation to a variety of ligands can further enhance the Lewis acidity allowing the hydrolysis of phosphoesters and even DNA. We show that...
Mostafa E Rateb, Yin Zhai, Emmanuelle Ehrner, Christopher Rath, Xiaoling Wang, Jioji Tabudravu, Rainer Ebel, mervyn bibb, Kwaku Kyeremehe, Pieter C. Dorrestein, Kui Hong, Marcel Jaspars and Hai Deng
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01269D, Paper
Linaridins are rare linear ribosomally-synthesized and post-translationally modified peptides (RiPPs) and only two, cypemycin and SBR-1832, in this family have been identified so far. Legonaridin 1 has been discovered as...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01280E, Paper
In 1954 Schlesinger and co-workers observed the direct reaction of diboron tetrachloride with simple organic compounds under mild conditions, the 1,2 addition product being formed with either ethylene or acetylene....
P. Srivastava, R. Abou El Asrar, C. Knies, M. Abramov, M. Froeyen, J. Rozenski, H. Rosemeyer and P. Herdewijn
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00898K, Paper
The search for prebiotic, nucleic acid precursors is, at its best, a speculative undertaking.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01438G, Paper
The rather exotic amino acid of the cyclomarins, is obtained in enantio- and diastereomerically pure and fully protected form.
Ping-Fan Chen, Kung-Kai Kuo, Jaya Kishore Vandavasi, Siva Senthil Kumar Boominathan, Chung-Yu Chen and Jeh-Jeng Wang
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01322D, Paper
A metal-free domino [3 + 2] cycloaddition is reported to construct naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives and provide an alternative approach to the azide–alkyne cycloadditions.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01146A, Paper
A regioselective synthesis of substituted pyrroloquinolinones by a ruthenium-catalyzed oxidative cyclization of substituted N-carbamoyl indolines with alkynes is described.
Mickael Jean, Bruna Casanova, Simone Gnoatto and Pierre van de Weghe
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01402F, Review Article
In 1998, Hayashi and Miyaura reported the first asymmetric conjugate addition of aryl- and alkenyl- boronic acids to α,β-unsaturated ketones using chiral rhodium complexes as catalysts. During the last decade,...
Raju Thombal and Vrushali H Jadhav
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01276G, Communication
The first total synthesis of anti-leukemic diterpene natural product EBC-329 (1) has been accomplished starting from readily available 6,6-dimethyl-3-oxabicyclo [3.1.0] hexane-2,4-dione (7). An efficient and general approach has been reported...
Lukas Vrzal, Marketa Kratochvilova-Simanova, Tomas Landovsky, Katerina Polivkova, Jan Budka, Hana Dvořáková and Pavel Lhotak
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01424G, Paper
Thiacalix[4]arene spirodienone was rearranged into the corresponding phenoxathiin-based macrocycle. Alkylation of this inherently chiral system to achieve its immobilization led to a mixture of only two (out of four theoretically...
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01201E, Paper
A sensor array based on polysulfonated fluorescent dyes can be used to differentiate purine and its derivatives with good precision.
Vijay Dhurandhare, Girija Prasad Mishra, Sarah Lam and Cheng-Chung Wang
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01017A, Paper
A direct installation of methyl phosphoramidate group by using methyl benzylphosphoramidochloridate into carbohydrates and amino acid is described. This one-step synthesis is efficient for both primary and secondary alcohols and...
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