Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
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Keith E. Coffey, Ryan Moreira, Farhana Z. Abbas and Graham K. Murphy
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02213K, Communication
An operationally simple conversion from hydrazones to gem-dichlorides occurs with broad functional group compatibility in moderate to high yield.
Huck K. Grover, Michael R. Emmett and Michael A. Kerr
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02117G, Review Article
Donor–acceptor cyclopropane annulations – not just for heterocycles.
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02244K, Communication
Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring...
K AnilKumar, Prakash Kannaboina, Devendra Kumar Dhaked, Ram A Vishwakarma, Prasad. V. Bharatam and Parthasarathi Das
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02044H, Paper
Cu (II)-Catalyzed cross-coupling of various aryl boronic acids with 5 and 6-amino indazoles has resulted the (arylamino)-indazoles. These resulted (arylamino)-indazoles have been utilized in synthesizing medicinally important pyrazole fused-carbazoles via...
Lorena Paseta, Gregory Potier, Steven Abbott and Joaquin Coronas
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01898B, Paper
Hansen solubility parameters (HSP) have found their greatest use in the evaluation of solvent-polymer chemical interactions. Given their great interest in the scientific community, host-guest interactions in metal-organic frameworks (MOFs),...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02256D, Paper
Selective control of enzyme activity is critical for elucidating the roles of specific proteins in signaling pathways. One potential means for developing truly target-specific inhibitors involves the use of protein...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02252A, Paper
Quorum sensing (QS) via the synthesis and detection of N-acyl L-homoserine lactone (AHL) signals regulates important pathogenic and mutualistic phenotypes in many bacteria. Over the past two decades, the development...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02029D, Paper
Understanding the influence of solute-solvent interactions on chemical reactivity has been a subject of intense research in the last decades. Theoretical studies have focused on bulk solvation phenomena and a...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02383H, Paper
Anion-radical coupling of structurally diverse series of aromatic compounds possessing biaryl linkages led to seven fused, polycyclic heterocycles in reasonable yields. The yield of the key step (K, toluene, O2)...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02365J, Paper
A mild, efficient and rapid domino reaction involving the Bestmann-Ohira reagent (BOR) and α,β-unsaturated aldehydes has been developed for the synthesis of densely functionalized vinylpyrazoles. This reaction demonstrates the dual...
Ahmed Kamal, Rahim Abdul, Sd Riyaz, Poornachandra Y, Balakrishna Moku, Ganesh Kumar C., Ali S. M. Hussaini, Sridhar Balasubramanian and Pavan Kumar Machiraju
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02277G, Paper
2-Styryl quinolines (9a-l) have been synthesized regioselectively from 2-methyl-quinoline by using NaOAc in water acetic acid binary solvents and evaluated for their antibacterial activity against both Gram-positive and Gram-negative strains....
Valentine Nenajdenko, M Vovk, Volodymyr Andriyovych Sukach, Viktor Mykolayovych Tkachuk and K Kovalchuk
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02233E, Paper
Regioselective base-catalyzed addition of nitromethane to 2-oxo-4-trifluoromethyl-1,2-dihydropyrimidine-5-carboxylates is reported. It was found that Michael-like pathway is highly reversible and substantially dominating under conditions of kinetic control (0–5 °C, 10 h)...
Haifan Wu, Fengyu She, Wenyang Gao, Austin Prince, Yaqiong Li, Lulu Wei, Allison Mercer, Lukasz Wojtas, Shengqian Ma and Jianfeng Cai
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02232G, Communication
Head-to-tail cyclic sulfono-γ-AApeptides.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02250E, Communication
An unprecedented protocol for the synthesis of thioesters via C–H thioesterification and C–O cleavage was developed. This CDC protocol was found convenient and easy-to-handle involving the use of DTBP as the only green oxidant.
Yusuke Yagi, Hiroyuki Kimura, Kenji Arimitsu, Masahiro Ono, Kazuya Maeda, Hiroyuki Kusuhara, Tetsuya Kajimoto, Yuichi Sugiyama and Hideo Saji
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01953A, Paper
Fluorine-18 labeled radiotracers, such as [18F]fluorodeoxyglucose, can be used as practical diagnostic agents in positron emission tomography (PET).
Le-Le Li, Jin-Ying Ding, Lian-Xun Gao and Fu-She Han
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01963F, Paper
We present an alternative pathway for the synthesis of aliskiren by applying the Evans chiral auxiliary-aided asymmetric allylation and the Julia–Kocienski olefination as the key transformations.
Stéphanie S. Le Corre, Nawal Belmadi, Mathieu Berchel, Tony Le Gall, Jean-Pierre Haelters, Pierre Lehn, Tristan Montier and Paul-Alain Jaffrès
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01770F, Paper
The synthesis of mono- and di-cationic lipophosphates is reported. These cationic lipids were formulated as liposomal solutions, and their capacity to transfect cells was evaluated on three cell lines.
Xiao-Liang Xu, Chun-Lei Yu, Wen Chen, Ying-Chao Li, Li-Juan Yang, Yan Li, Hong-Bin Zhang and Xiao-Dong Yang
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02385D, Paper
A series of novel 2-substituted indoline imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence...
Benito Alcaide, Pedro Almendros, Cristina Aragoncillo, Ricardo Callejo, María Pilar Ruiz and M. Rosario Torres
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02289K, Paper
Passerini (P-3CR) and Ugi (U-4CR) reactions were investigated in 4-oxoazetidine-2-carboxaldehydes affording the corresponding Passerini and Ugi adducts with moderate diastereoselectivity in high yields. Fortunately, the obtained mixtures of isomers syn/anti...
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02133A, Communication
A bioorthogonal method of transforming 3-nitrotyrosine to 3-azidotyrosine is described, providing new opportunities to study 3-nitrotyrosine in biological samples.
Aysegul Cort, Tomris Ozben, Anna Sansone, Sebastian Barata-Vallejo, Chryssostomos Chatgilialoglu and Carla Ferreri
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01924E, Paper
Bleomycin–iron complexes cause lipid cistrans isomerisation through thiyl radical formation and reactivity with unsaturated phospholipids, revealing membranes as a relevant and novel site of drug effect.
Bruno Commare, Delphine Rigault, Isabelle A. Lemasson, Patrick Deschamps, Alain Tomas, Pascal Roussel, Isabelle Brabet, Cyril Goudet, Jean-Philippe Pin, Frédéric R. Leroux, Françoise Colobert and Francine C. Acher
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01960A, Paper
Stereomers of LSP1-2111 have been separated, their absolute configuration and agonist activity at mGlu4R determined.
Maria Vetro, Barbara Costa, Giulia Donvito, Noemi Arrighetti, Laura Cipolla, Paola Perego, Federica Compostella, Fiamma Ronchetti and Diego Colombo
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01602E, Paper
Long chain GlcADG analogues synthesized as PI3P mimics inhibited isolated Akt and proliferation of human ovarian carcinoma IGROV-1 cells.
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02251C, Paper
From themed collection In celebration of Seiji Shinkai's 70th Birthday
Cavitand 1 possesses four 2,2'-bipirydyl pillars on its upper rim that encapsulate small guests, such as nitromethane, acetonitrile, methyl acetate, ethyl acetate, and N-methylacetamide, into a deep cavity to form...
Mykhaylo S. Frasinyuk, Svitlana P. Bondarenko, Volodymyr P. Khilya, Chunming Liu, David S. Watt and Vitaliy M. Sviripa
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02137A, Paper
Aminomethylation of 7-hydroxy isoflavones with C2–C5 ω-aminoalcohols led to tautomers 4 and 5 that were interconverted as confirmed by NMR studies.
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