Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.568 48 Issues per Year Indexed in MEDLINE
 
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Nobuya Tsuji, Michael Stadler, Naoya Kazumi, Tsubasa Inokuma, Yusuke Kobayashi and Yoshiji Takemoto
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01678E, Communication
A facile and catalytic asymmetric synthesis of the pentacyclic core of (–)-nakadomarin A, containing all the stereogenic centers of the natural product, was achieved. The key intermediate involves oxazolidine moiety...
 
RENZO LUISI, Rosmara Mansueto, Leonardo Degennaro, Jean-François Brière, Karen Griffin, Mike Shipman and Saverio Florio
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01457J, Paper
The origin of the stereoselectivity in the lithiation/trapping of 2-alkylideneaziridines bearing a chiral group as the nitrogen substituent, has been investigated. Optimal reaction conditions have been discovered by in situ...
 
Bin He, Jing Hu, Xiaoyu Zhang and Hening Lin
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00860J, Communication
Potent mechanism-based Sirt6 inhibitors.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01179A, Communication
A mild method for the efficient synthesis of 3,3-dichloro-2-sulfonyliminoindolines via AcOH-mediated dichloroimination of indoles using chloramine-B is described.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01654H, Communication
A new method for aryne generation enabled facile synthesis of diverse bis- and tris-1,2,3-triazoles.
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01375A, Paper
Detergents are widely used for membrane protein research; however, membrane proteins encapsulated in micelles formed by conventional detergents tend to undergo structural degradation, necessitating the development of new agents with...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01143K, Paper
The synthesis is described of a series of meta and para-substituted phenylsulfonic acid derivatives of very bright Eu(III) complexes with arylphosphinate groups and strongly absorbing arylalkynylpyridine moieties. The synthetic route...
 
Tatina Madhubabu, Anil Kumar Kusunuru, syed khalid Yousuf and debaraj mukherjee
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01405G, Communication
Zinc mediated alkynylation reaction was studied for the preparation of C-glycosides from unactivated alkynes. Different glycosyl donors such as glycals and anomeric acetates were tested towards alkynyl zinc reagent obtained...
 
Yogesh Daulat Dhage, Hiroki Daimon, Cheng Peng, Taichi Kusakabe, Keisuke Takahashi, Yuichro Kanno, Yoshio Inouye and Keisuke Kato
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01576B, Paper
Cyclization-carbonylation of α,β-Alkynic hydrazones and (o-alkynylphenyl) (methoxymethyl) sulfides with Pd(tfa)2 in DMSO / MeOH afforded methyl pyrazole-4-carboxylates and benzo[b]thiophene-3-carboxylates, respectively, in good yields. A simple change of ligand (solvent) allowed...
 
Jeeun Woo, Gunwoo Kim, Kevanie Quintero, Michael P Hanrahan, Hector Palencia and Haishi Cao
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01500B, Paper
A reaction-based chemosensor (AF-1) was designed, synthesized and applied as an optical approach for quantitative measurement of F- in MeCN. In the presence of F-, selective fluoride-assisted desilylation instantly gave...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01422G, Paper
Glycosaminoglycans contain a -D-xylopyranose residue at its reducing end, which links the polysaccharide to the protein in proteoglycans. 2-Naphthyl -D-xylopyranosides have shown inhibition of tumor growth and we herein investigate...
 
Kah-Yee Li, Jianbing Jiang, Martin D. Witte, Wouter W. Kallemeijn, Wilma E. Donker-Koopman, Rolf G. Boot, Johannes M. F. G. Aerts, Jeroen D. C. Codée, Gijsbert A. van der Marel and Herman S. Overkleeft
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01611D, Paper
Of six cyclophellitol analogues, the N-pentylaziridine is the most effective retaining human beta-glucosidase inhibitor considering potency and compound stability.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01417K, Paper
Compounds of high synthetic value were produced in a much more efficient manner than was previously possible through fermentation.
 
Jin-Long Gong, Xinxin Qi, Duo Wei, Jian-Bo Feng and Xiao-Feng Wu
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01633E, Communication
An interesting and practical metal-free strategy has been developed for the synthesis of aromatic aldehydes using various N,N-dimethylbenzylamines as starting materials.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01235F, Paper
An oxidative homocoupling of organomanganese reagents was performed in one pot without an additional transition-metal catalyst.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01384K, Communication
An efficient aziridine ring expansion cascade of cinnamylaziridine has been developed using N-bromosuccinimide as the promoter.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01296H, Paper
2-Arylquinazolines were prepared from nitroarenes and benzyl alcohols or benzyl amines via a hydrogen transfer strategy.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01429D, Paper
A novel two-step strategy allowed us to selectively monofunctionalize a molecular host (calix[6]arene) with various groups of interest (redox tag, fluorophore, chelating ligand).
 
Jens Hartung, Christine Schur, Harald Kelm, Arne Ludwig, Thomas Gottwald and Rainer Kneuer
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01266F, Paper
4-Pentenoxyl radicals sharing two or more carbon atoms with a cycloalkane cyclize in a predictable manner stereoselectively and regioselectively, to afford in solutions of bromotrichloromethane cycloalkyl-fused or -bridged 2-bromomethyltetrahydrofurans in...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00978A, Paper
A palladium-catalyzed direct addition of arylboronic acids to unprotected 2-aminobenzonitriles has been developed, leading to a wide range of 2-aminobenzophenones with moderate to excellent yields. The transformation has broad scope...
 
Raul Perez-Ruiz, José Antonio Sáez, M. Consuelo Jimenez and Miguel Miranda
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01416B, Paper
The radical anions of β-lactams, photogenerated in the presence of DABCO as electron donor, undergo cycloreversion via N-C4 bond cleavage, back electron transfer and final C2-C3 bond cleavage, leading to...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01400F, Paper
Asymmetric total synthesis of naturally occurring Resorcylic acid lactone paecilomycin E and two of its structural congeners have been reported in this article. The major highlight of the synthetic venture...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01419G, Paper
The reaction coordinates of an archetypical set of 5-exo cyclizations of C-, N- and O-centred radicals were investigated by computational methods. G4 theory, and DFT with the um062x functional, were...
 
Haibing Zhou, Xin Han, Haoming Wu, Shu Wen Wu, wei wang, Chune Dong and Po Tien
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01333F, Paper
Series of non-nucleoside reverse transcriptase inhibitors derived from indole-based α-amino acids were designed and synthesized. Their inhibitory activities have been detected by a TZM-bl cell assay on HIV virus type...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01432D, Review Article
Non-conventional heating techniques, high-throughput microwave-assisted synthesis and continuous flow penetrate almost every scientific field. Mitsunobu coupling is a ubiquitous choice for the dehydrative redox condensation of primary or secondary alcohols...
 
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