Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.568 48 Issues per Year Indexed in MEDLINE
 
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Jean Paul Bourgault, Amarendar Reddy Maddirala and Peter R. Andreana
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01148A, Communication
The herbicide (±)-thaxtomin A has been synthesized in a one-pot two step process through an Ugi reaction followed by base-mediated cyclization.
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01329H, Paper
Natural carbasugars are important class of biologically active compounds. Due to their conformational freedom and due to the subtle difference in spectral characteristics between isomers, often their NMR-based structural assignments...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00977K, Paper
We report on a significant effect of locked nucleic acid (LNA) nucleobases on the binding of amiloride for abasic site (AP)-containing DNA duplexes. Fluorescence titration experiments showed that the binding...
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01158A, Paper
PNA replication via decameric template directed cross-catalytic ligation follows product inhibited kinetics yielding approximately two replication rounds.
 
Shuai Fang, Xiaoyi Niu, Zeyuan Zhang, Yan Sun, Xiaomeng Si, Cuicui Shan, Lei Wei, Aiqing Xu, Lei Feng and Chen Ma
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00871E, Paper
A one-pot transition metal-free methodology for constructing pharmacologically active dibenzodiazepine derivatives was developed.
 
Jesse V. Gavette, Kang-Da Zhang, Dariush Ajami and Julius Rebek
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01032A, Communication
A deep cavitand with ionic “feet” dimerizes around hydrophobic compounds in D2O.
 
Sariya Yodwaree, Darunee Soorukram, Chutima Kuhakarn, Patoomratana Tuchinda, Vichai Reutrakul and Manat Pohmakotr
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01078G, Paper
The formal synthesis of (+)-3-epi-eupomatilone-6 and the 3,5-bis-epimer has been accomplished using stereoselective conjugate addition of vinylmagnesium chloride to a chiral α,β-unsaturated N-acyl oxazolidinone followed by α-methylation as the key steps.
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01211A, Communication
Direct intermolecular C-H arylation employing aryl bromide as the arene source has been developed. This process proceeds via a simple transition-metal free pathway. With the aid of inexpensive and commercially...
 
Fan Zhao, Balthasar A. Heesters, Isaac Chiu, Yuan Gao, Junfeng Shi, Ning Zhou, Michael C. Carroll and Bing Xu
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01362J, Communication
An L-rhamnose-based hydrogelator self-assembles to form nanofibrils, which, contrasting to the properties of monomeric L-rhamnose, suppress the antibody response of mice to phycoerythrin (PE), a fluorescent protein antigen. As the...
 
Anand D Tiwari, Siva S Panda, AS Girgis, Sandhyamayee Sahu, Riham F George, Aladdin M Srour, Brian La Starza, Abdullah M. Asiri, Charles Dennis Hall and Alan R Katritzky
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01281J, Paper
Novel, 6a–l non-steroidal anti-inflammatory drug (NSAID), acetaminophen conjugates with amino acid linkers were synthesized utilizing benzotriazole chemistry. Biological data acquired for all the novel bis-conjugates showed (a) some bis-conjugates (6b,...
 
Linman He, Guanyinsheng Qiu, Yueqiu Gao and Jie Wu
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01286K, Review Article
This minireview draws a conclusion on the applications of in situ generated diazonium salts from anilines in organic synthesis. In situ generation of diazonium salts from anilines represents an efficient...
 
Mina Barzegar Amiri Olia, Carl H. Schiesser and Michelle K. Taylor
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01172D, Review Article
This short review highlights recent progress in the development of reagents for the detection of free radicals and reactive oxygen species, a key step on the road to their understanding and ultimate control.
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01091D, Paper
A range of α-aryl substituted γ-ketophosphonates is synthesised by Lewis acid mediated reactions of 1,3-diketones and easily accessible, inexpensive benzylic α-hydroxyphosphonates in an operationally-simple method under solvent-free conditions without exclusion...
 
Lachlan M. Blair, Elizabeth A. Colby Davie and Jonathan Sperry
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01304B, Paper
The spectroscopic data for synthetic montamine does not match the proposed N,N′-linked structure and closely resembles a known 4,4′-bismoschamine natural product.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01057D, Paper
An efficient Lewis acid-catalyzed tandem selective ring-opening and Friedel–Crafts alkylation of 1H-indol-1-yl derived oxiranes was developed.
 
Arun K. Ghosh, Gary E. Schiltz, Linah N. Rusere, Heather L. Osswald, D. Eric Walters, Masayuki Amano and Hiroaki Mitsuya
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00738G, Paper
A series of potent macrocyclic HIV-1 protease inhibitors have been designed and synthesized.
 
Young-Ger Suh, Hwayoung Yun, Jaehoon Sim, Hongchan An, Jeeyeon Lee, Hun Seok Lee, Young Kee Shin and Seung-Mann Paek
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01028K, Paper
The rational design and synthesis of a biochemical probe of natural (+)-macrosphelide A, a potent cell-cell adhesion inhibitor, was completed to aid in the identification of its biological target. The...
 
Hao Chen Wu, Hui Ming Ge, Le Yun Zang, Yun Cheng Bei, Zhi Yuan Niu, Wei Wei, Xiu Jing Feng, Sen Ding, Seik Weng Ng, Ping Ping Shen and Ren Xiang Tan
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01123F, Communication
Diaporine (1), an unprecedented symmetric polyketide, was characterized from the endophytic fungus Diaporthe sp. Diaporine was demonstrated to inhibit significantly the differentiation of macrophages.
 
Maksims Yevglevskis, Catherine R. Bowskill, Chloe C. Y. Chan, Justin H.-J. Heng, Michael D. Threadgill, Timothy J. Woodman and Matthew D. Lloyd
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C3OB42515K, Paper
Mandelic acid 1 undergoes uni-directional chiral inversion in mammalian cells by a separate pathway to that of Ibuprofen 3.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01025F, Communication
An oxidative olefination reaction between aliphatic primary amines and benzylic sp3 C–H bonds has been achieved using N-bromosuccinimide as catalyst and tert-butyl hydroperoxide as oxidant.
 
Di Zhang, Wei Chen, Jianming Kang, Yong Ye, Yufen Zhao and Ming Xian
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01031K, Paper
Three sulfonyl benzothiazole-based fluorescence off–on probes for biothiols are developed and applied for visualizing endogenous thiols in living cells.
 
Ziyong Li, Fang Hu, Guoxing Liu, Wen Xue, Xiaoqiang Chen, Sheng Hua Liu and Jun Yin
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01120A, Paper
A series of novel dithienylethene-based macrocycles containing ammonium moieties has been synthesized.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00486H, Paper
Selective inhibition by conformational restriction of pyrrolidine iminosugars. Click conceived pyrrolidotriazoles incorporate essential features to access the mimicry of the transition state of carbohydrate processing enzymes.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01101E, Communication
A series of novel ring expanded N-heterocyclic carbene (NHC) precursors were synthesized, which showed excellent enantioselectivities for borylation of α,β-unsaturated esters.
 
Subhasish Chatterjee, Rafael Prados-Rosales, Sindy Tan, Boris Itin, Arturo Casadevall and Ruth E. Stark
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01066C, Paper
Comparing natural and synthetic eumelanin pigment structures: high-field 2D solid-state NMR reveals a common indole-based aromatic core for ubiquitous protective pigments that inspire engineered materials.
 
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