Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
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Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02146K, Communication
Primary amino acids are found to be good enantioselective catalysts for the direct asymmetric Mannich reaction between 2-amino acetophenone and aldehydes. The 2-aryl-2,3-dihydro-4-quinoline products are obtained in moderate to good...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02003K, Paper
NMR and organocatalytic studies of four dipeptides derived from L-proline are described. Results indicate that important conformational changes around the catalytic L-proline moiety are observed for free dipeptides upon changing...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01744G, Paper
The vicinal disubstitution reaction of diaryliodonium salts with pyridine N-sulfonamidates were fully examined to afford o-pyridinium anilines. A pathway of N-arylation occurred at the amidate group followed by a radical...
Xi-Sheng Wang, Yan Wang, Kai Zhou and Quan Lan
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02039A, Communication
The first example of palladium-catalyzed ortho-C–H arylation of aryl and benzyl Weinreb amides was developed, in which HOTf was used as a key promoter. This method exhibits good functional groups...
Filippo Doria, Marco Folini, Vincenzo Grande, Graziella Cimino-Reale, Nadia Zaffaroni and Mauro Freccero
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02054E, Paper
A small library of hydrosoluble naphthalene diimides (NDIs) was designed and synthesized, as cell permeable pH “turned-on” fluorescent sensors, for cellular applications. The NDIs exhibit a non-emitting twisted intramolecular charge...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01734J, Paper
The protein arginine N-methyltransferases (PRMTs) are a family of enzymes that function by specifically transferring a methyl group from the cofactor S-adenosyl-L-methionine (AdoMet) to the guanidine group of arginine residues...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02134G, Paper
Alkenylboranes R-CH=CH-B(C6F5)2 undergo carbon-carbon coupling by means of 1,1-alkenylboration with diarylphosphino-enynes to give substituted conjugated hexatriene derivatives that bear a vicinal pair of B(C6F5)2 Lewis acid and PAr2 Lewis base...
Yu-Fa Wu, Yow-Fu Tsai, Jhe-Ruei Guo, Cheng-Ping Yu, Hui-Ming Yu and Chun-Chen Liao
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01882F, Communication
The first total synthesis of ganglioside DSG-A (1) is achieved via chemoselective glycosylation and a [1 + 1 + 2] synthetic strategy.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB02001D, Communication
The selective detection of picric acid among other organic acidic analytes (A's) was achieved via a pKa compatibility approach by tuning the pKa of RSLs (1 and 2) by adjusting the proportion of non-aqueous component in a mixed solvent medium (bar).
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01087F, Paper
Palladium-catalyzed allylic substitutions of ortho-substituted anilides using P/olefin ligands were achieved to afford chiral anilides with up to 84% ee.
Anjani K. Tiwari, Masayuki Fujinaga, Joji Yui, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Anil K. Mishra, Yoko Shimoda, Akiko Hatori, Bin Ji, Masanao Ogawa, Kazunori Kawamura, Feng Wang and Ming-Rong Zhang
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01933D, Paper
Two new PET ligands for TSPO imaging in brain.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01912A, Paper
An efficient methodology for the ortho benzoxylation of 2-phenylpyridine via C–H bond activation using benzyl alcohols and benzyl amines as arylcarboxy sources has been developed.
Balla Chandrasekhar, Sudhakar Athe, P. Purushotham Reddy and Subhash Ghosh
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01716A, Paper
Synthesis of fully functionalized aglycone of lycoperdinoside A and B is achieved via Pd-catalyzed Stille–Migita cross coupling and Evans syn- and anti aldol reactions as key steps.
Jingjie Tang, Mei Cong, Yi Xia, Gilles Quéléver, Yuting Fan, Fanqi Qu and Ling Peng
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01836B, Paper
Pd-catalyzed oxidative C–H alkenylation: an effective method for synthesizing arylvinyltriazole nucleosides in good yields and with large functional group tolerance.
Sabah Abada, Alexandre Lecointre, Câline Christine, Laurence Ehret-Sabatier, Falk Saupe, Gertraud Orend, David Brasse, Ali Ouadi, Thomas Hussenet, Patrice Laquerrière, Mourad Elhabiri and Loïc J. Charbonnière
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01514B, Paper
A series of phosphonated chelates and their coordination properties is described. SPECT/CT imaging studies with 99mTc using two ligands and a bifunctional chelate labeled to a tumor targeting antibody are shown.
Serena Mostarda, Paolo Filipponi, Roccaldo Sardella, Francesco Venturoni, Benedetto Natalini, Roberto Pellicciari and Antimo Gioiello
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01911C, Paper
An efficient method for the C3-glucuronidation of bile acids is developed under flow conditions.
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01810A, Communication
A novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates was synthesized and evaluated by photochemical characterization and cell-based assays. The specific responsiveness to the cytoplasmic entry...
Chou-Hsiung Chen, Sivaneswary Genapathy, Peter M Fischer and Weng Chan
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02107J, Communication
A facile route has been established for the synthesis of indole-substituted (S)-tryptophans from corresponding indoles, which utilizes a chiral auxiliary-facilitated Strecker amino acid synthesis strategy. The chiral auxiliary reagents evaluated...
Simon A. Dingsdag, Benjamin C-M. Yap, Neil Hunter and Maxwell J. Crossley
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01841A, Paper
Amino acid-linked porphyrin-nitroimidazole adducts, as potent as metronidazole, are highly selective for Porphyromonas gingivalis.
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01977F, Paper
An efficient acid induced rearrangement of tetrahalo-7,7-dimethoxybicyclo[2.2.1]heptenyl system leading to substituted indenones is reported. This domino reaction involves dehydration, olefin isomerization, ketal hydrolysis, [3,3]-sigmatropic rearrangement and dehydrohalogenation. The resultant vicinal...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02079K, Communication
Regioselective S-acylation of coenzyme A (CoA) is achieved under aqueous conditions using various aliphatic and aromatic carboxylic acids activated as their methyl acyl phosphate monoesters. Unlike many hydrophobic activating groups,...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02061H, Paper
Divergent C-H functionalization reactions (arylation, carboxylation, olefination, thiolation, acetoxylation, halogenation, naphthylation) using a pyridazinone moiety as an internal directing group were successfully established. This approach offers a late-stage, ortho-selective diversification...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01801J, Paper
A novel and highly stereoselective synthesis of Z-β-enaminonitriles from azides and α,β-unsaturated nitriles is reported. The reaction proceeds via a 1,3-dipolar cycloaddition–ring cleavage–rearrangement cascade mediated by catalytic amount of Sc(OTf)3....
Rosario Hern�ndez- Gal�n, Jose Manuel Botubol, María Jesús Durán-Peña, Antonio Jose Macias-Sanchez, I. G. Collado and James R Hanson
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01792G, Paper
The synthesis of several derivatives of 3-hydroxy-2,4,8-trimethyldec-8-enolide and attempts at the synthesis of 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide (1), a structure which has been assigned to a metabolite of the phytopathogenic fungus, Botrytis cinerea,...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01627K, Paper
Highly regioselective (3+2) cycloadditions of (trifluoromethanesulfonyloxy)benzynes [(triflyloxy)benzynes] with 1,3-dipoles followed by cross-coupling reactions provided multisubstituted benzo-fused heterocycles. The triflyloxy group at the 3-position of benzynes, and even that at the...
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