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Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
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Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00167F, Paper
The relationship between two aminopolysaccharide stereoisomers, namely alpha-(1,4)- and beta-(1,4)-linked (N-acetyl)-D-glucosamine polymers, is of significant interest within the field of polysaccharide science, as they correspond to amino analogs of the...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00317B, Communication
A highly enantioselective Michael addition of 3-monosubstituted oxindoles to α,β-unsaturated acyl phosphonates with chiral squaramides as catalysts was investigated for the first time. A wide range of 3,3'-disubstituted oxindole adducts...
lingyan liu, Jing Li, xiufang xu, Kaimeng Huang, Hongkai Wang, Junying Wang, Xiaona Ke and Chenchen Zhou
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02336F, Paper
A novel cyclization of 3-acyloxy-1,5-enynes was developed in the presence of PtI2 for the synthesis of substituted unsymmetrical m-terphenyls in good to excellent yields. Two unique steps were involved in...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00067J, Communication
A practical synthesis of novel tryptamine-based macrocycles using a Ugi 4-CR/click-cycloaddition sequential reaction protocol is descrived. The main features of the macrocyclic scaffolds are a peptoid moiety, a 1,3-substituted indole...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00102A, Paper
Palladium-catalyzed heteroarylation of 1-substituted 1,2,3-triazoles with furans and thiophens has been developed, in the presence of pyridine and Ag2CO3. The procedure is suitable for the regioselective preparation of 1,5-disubstituted 1,2,3-triazoles...
Rachel E. Morgan, Vijay Chudasama, Paul Moody, Mark E. B. Smith and Stephen Caddick
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00130G, Communication
Site-specific ubiquitin cysteine mutants enable an elegant method for the linkage-specific conjugation of ubiquitins through dibromomaleimides and dibromopyrdazinediones.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00122F, Paper
Decomposition of aminoacyl-substituted D-galactoside scaffolds under acidic conditions is dependent on the length of the side chain and is accelerated by the presence of a free hydroxyl group at C-6. In the latter case, evidence is provided that the reaction occurs via an N- to O-acyl transfer.
Edward C. Sherer, James R. Cheeseman and R. Thomas Williamson
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00082C, Communication
The absolute configuration of remisporine B was determined based on a comparison of experimental and calculated electronic circular dichorism (ECD) spectra.
De-Cai Xiong, Jingjing Zhu, Ming-Jie Han, Hui-Xin Luo, Cong Wang, Yang Yu, Yuqian Ye, Guihua Tai and Xin-Shan Ye
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00069F, Paper
A minimal and efficient cyclopropene chemical handle was identified both in vitro and in vivo.
Seok-Hwi Park, Xiangdan Jin, Jong-Cheol Kang, Changyoung Jung, Seong-Soo Kim, Sung-Soo Kim, Kee-Young Lee and Won Hun Ham
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00251F, Paper
Concise and stereocontrolled syntheses of (+)-hyacinthacine A2 and sphingofungin B were achieved via a diastereomerically enriched oxazine intermediate. The key strategies include palladium(0)-catalyzed intramolecular oxazine formation and diastereoselective nucleophilic addition...
Elena Pazos, Cecilia Portela, Cristina Penas, M. Eugenio Vázquez and Jose Luis Mascareñas
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00318K, Paper
We describe a ds-oligonucleotide-peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00042D, Paper
Two dibenzoxanthenium derivatives bearing a 3,4-diaminophenyl group, compounds 1a and 1b, have been prepared and evaluated as near-infrared probes for the detection of nitric oxide. Compound 1a gave a 3-fold...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00162E, Communication
A ruthenium-catalyzed one-pot synthesis of 2,4-diarylsubstituted pyridines from acetophenones, ammonium acetate and DMF under oxygen atmosphere is described. The carbon atom situated at C6 of the pyridine ring comes from...
Wenjing Shang, Zhongying Xiao, Zaikuan Yu, Na Wei, Guohui Zhao, Qing Zhang, Mohui Wei, Xuan Wang, Peng George Wang and Tiehai Li
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00177C, Paper
Lipopolysaccharides (LPS), major virulence determinants in Gram?negative bacteria, are responsible for many pathophysiological responses and can elicit strong immune responses. In order to better understand the role of LPS in...
Changjiang Yang, Juanjuan Li, Rong Zhou, Xiangyu Chen, Yunpeng Gao and Zhengjie He
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00258C, Paper
Novel spirooxindole-pyrazolines and spirobenzofuranone-pyrazolines have been synthesized in good to excellent yields via the annulation reactions of the corresponding 3-alkylideneoxindoles and 3-alkylidenebenzofuranones with Huisgen zwitterions. The preliminary bioassay has demonstrated...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00229J, Paper
An efficient and scalable synthesis of various enantiopure 1,3- disubstituted isoindolines are reported. The base catalyzed nucleophilic fragmentation of a rigid overbred template is established with various substrates to afford...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00216H, Paper
A short synthetic route to the trimethyl ether of brazilin was developed in 6 steps from 7-methoxychromene with 78% overall yield. Regioselective installation of a formyl group onto 7-methoxychromene followed...
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00108K, Paper
A recently introduced new SPS resin, possessing an 2-(ortho-nitrophenyl)ethanal linker, was used for the regioselective on-resin synthesis of N-mono-hydroxylated and N-mono-methylated polyamine spider toxins of Agelenopsis aperta and Larinioides folium....
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02405B, Paper
Pyrrolobenzodiazepine (PBD) monomer GWL-78 reacts faster with DNA hairpins containing a hexaethylene glycol (HEG) loop compared to hairpins containing a TTT loop due to the greater structural flexibility of the HEG.
Geoffrey M. Williams, Kathryn Lee, Xun Li, Garth J. S. Cooper and Margaret A. Brimble
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00160A, Paper
Two analogues of insulin glargine containing a 1,4-disubstituted 1,2,3-triazole group in place of the CysA7–CysB7 disulfide bond were prepared using CuAAC click chemistry to efficiently join the peptide chains.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00184F, Paper
A series of glycoluril molecular clips and acyclic CB[n]-type receptors are tested as solubilizing agents for insoluble drugs.
V. Alterio, M. Tanc, J. Ivanova, R. Zalubovskis, I. Vozny, S. M. Monti, A. Di Fiore, G. De Simone and C. T. Supuran
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02648A, Paper
Sulfamoylated saccharin binds to human carbonic anhydrase II through the SO2NH2 and not CONHSO2 moiety.
Charlotte M. Miller, Tore Benneche and Marcus A. Tius
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00074B, Paper
The first total synthesis of the marine prostanoids clavulolactones II and III is presented from an easily accessible chiral, non-racemic cyclopentenone intermediate.
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00099H, Review Article
This review categorizes the active intermediates generated from denitrogenation of vinyl azides under different reaction conditions, and highlights newly discovered transformations of vinyl azides that lead to convenient syntheses of N-heterocycles.
Devendar Reddy Kommidi, ramakanth pagadala, Surjyakanta Rana, Parvesh Singh, Suhas Ashok Shintre, Neil Koorbanally, Sreekantha Babu Jonnalagadda and Brenda Moodley
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00197H, Paper
One pot efficient synthetic protocol is described for the synthesis of carbapenem chalcone derivatives using AAPTMS@MCM-41 heterogeneous catalyst. Various substituted aromatic aldehydes were attached to highly chiral and reactive carbapenem...
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