Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
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Alexandre BRUNEAU, Jean Daniel BRION, SAMIR MESSAOUDI and Mouad Alami
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01610F, Paper
3-(heteroaryl)quinolin-2(1H)-ones were synthesized in good to excellent yields using a bimetallic catalytic system through C-H heteroarylation strategy. Starting from 3-bromoquinolin-2(1H)-ones, various azoles have been successfully used. In all cases, the...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01662A, Paper
The first enantioselective total syntheses of the proposed structures of the natural product prevezol B are reported. The reported syntheses complement the previously-reported syntheses of the proposed structures of prevezol...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00894D, Paper
We report here the theoretical analysis of the mechanism and regioselectivity of gold (I) or platinum (II) catalyzed intramolecular hydroarylation to pyrrolopyridinones and pyrroloazepinones. AuPH3+ and PtCl2 have been considered...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01534G, Paper
A facile and direct synthetic method was developed for the construction of structurally important 2-aminothiophenes in moderate to excellent yields (up to 91%), via Cu(II)-catalyzed addition/oxidative cyclization of readily available...
Marina Kovaliov, Chaim Wachtel, Eylon Yavin and Bilha Fischer
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01185F, Paper
dUDAB modified probes are promising probes for gene quantification in real-time PCR detection and as photoswitchable devices.
Ondřej Šimák, Petr Pachl, Milan Fábry, Miloš Buděšínský, Tomáš Jandušík, Aleš Hnízda, Radka Skleničková, Magdalena Petrová, Václav Veverka, Pavlína Řezáčová, Jiří Brynda and Ivan Rosenberg
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01332H, Paper
Conformationally constrained nucleoside phosphonic acids – potent inhibitors of human mitochondrial and cytosolic 5′(3′)-deoxynucleotidases.
Hirotaka Akiyama, Takafumi Inoue, Nobuo Tajima, Reiko Kuroda and Yoshitane Imai
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01058B, Paper
Naphthoquinone pigments 2-methyl-3-(4- or 2-hydroxyphenylthio)-1,4-naphthalenedione show characteristic multiple optical properties in solution and in the solid state.
Siddamal Reddy Putapatri, Abhinav Kanwal, Balasubramanian Sridhar, Sanjay K. Banerjee and Srinivas Kantevari
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01319K, Paper
Fused chiral bicyclic 1,2,3-triazoles synthesized from commercially available natural L-rhamnose exhibited excellent SGLT inhibition activity.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01305K, Paper
We report a new method for the synthesis of bis-indolizine and bis-cyclopropane derivatives under ultrasound irradiation, using a 1,3-dipolar cycloaddition reaction or a cyclopropanation reaction, respectively.
Rodolfo Marquez, Tom Cogswell, Craig Donald and Deliang Long
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01547A, Paper
The diastereoselective synthesis of fluorinated δ-lactams has been achieved through an efficient five step process. The route can tolerate a range of functionality, and provides a quick route for the...
Wannian Zhao, Ping Xie, Min Zhang, Ben Niu, Zhaogang Bian, Charles Pittman and Aihua Zhou
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01442A, Communication
A cascade reaction between N-alkyl-N-methacryloylbenzamide and aryl aldehydes was developed to generate isoquinoline-1,3(2H,4H)-dione derivatives.
Ryo Katoono, Keiichi Kusaka, Shunsuke Kawai, Yuki Tanaka, Keisuke Hanada, Tatsuo Nehira, Kenshu Fujiwara and Takanori Suzuki
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01601G, Paper
We designed hexakis(phenylethynyl)benzene derivatives with a tertiary amide group on each blade to achieve a helically-biased propeller arrangement through the complexation-induced intramolecular transmission of point chirality. A hydrogen-bonding ditopic guest...
Channe D Gowda, Maralinganadoddi P Sadashiva, Ajjampura C Vinayaka, Xianzhu Wu, Sergei Biryukov, Jose A Stoute and Kanchugarakoppal S Rangappa
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01455C, Paper
A new strategy was developed to synthesize 1,2-disubstituted 4-quinolones in good yield starting from 1,3-bisaryl-monothio-1,3-diketone substrates. The synthesized compounds were evaluated for antimalarial activity using Plasmodium falciparum strains. All compounds,...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01509F, Communication
A few pyrene-based fluorescent compounds were synthesized using Pd/Cu-catalyzed cross-coupling reaction. Photophysical properties of the π-conjugated pyrene derivatives were studied and the results indicate materials with high quantum efficiency and...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01504E, Communication
A cascade coupling reaction toward a variety of phenanthridine derivatives has been developed. This cascade trans-formation proceeds via the copper-catalyzed coupling reaction of diaryliodonium salts and nitriles, undergoes cyclization into...
Benjamin M Schulze, Davita L Watkins, Jing Zhang, Ion Ghiviriga and Ronald K Castellano
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01373E, Communication
Reported is characterization of the self-assembly of π-conjugated oligomers, molecules studied recently in photovoltaic devices, using variable temperature diffusion ordered spectroscopy (VT-DOSY). Iterative fitting of diffusion coefficient versus temperature data...
Fernando Albericio, Yahya Jad, Sherine Khattab, Beatriz G. De la Torre, Thavendran Govender, Gert Kruger and Ayman El-Faham
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01612B, Communication
Peptide-bond formation is a key process in the synthesis of peptide oligomers. Among the many coupling techniques reported, carbodiimides combine strong acylation potency and smooth reaction conditions and are commonly...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01594K, Paper
We report herein the NHC-Pd(II)-Im complex 1 catalyzed direct C-H bond functionalization of C9-position of fluorenes with aryl chlorides and further transformation of the resulting products in a one-pot procedure....
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01460J, Paper
A novel and efficient method for one-pot synthesis of 2,4-disubstituted thiazoles from carboxylic acids or anhydrides is established. Based on this new methodology, the total synthesis of bis-2,4-disubstituted bis(thiazoles) natural...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01548G, Paper
HBTU is a standard coupling agent commonly used for the activation of free carboxylic acids during the solution and solid phase peptide synthesis. 1-Hydroxybezotriazole (HOBt) plays a significant role in...
Oliver Roling, Artur Mardyukov, Sebastian Lamping, Benjamin Vonhören, Stefan Rinnen, Heinrich F. Arlinghaus, Armido Studer and Bart Jan Ravoo
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01379D, Paper
Bioorthogonal ligation methods are the focus of current research due to their versatile applications in biotechnology and materials science for post-functionalization and immobilization of biomolecules.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01396D, Paper
Density functional theory calculations on melatonin, metabolites and synthetic derivatives thereof, and a range of other biological antioxidant molecules are presented, with a view to understanding the antioxidant ability of these molecules.
Bit Lee, Halesha D. Basavarajappa, Rania S. Sulaiman, Xiang Fei, Seung-Yong Seo and Timothy W. Corson
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01604A, Communication
The homoisoflavanone cremastranone is synthesized for the first time and shown to block human retinal endothelial cell angiogenesis in vitro.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01369G, Communication
A novel and efficient iron-catalyzed direct difunctionalization of alkenes with sulfinic acids and dioxygen for the synthesis of β-ketosulfones has been developed.
R. Matovic, F. Bihelovic, M. Gruden-Pavlovic and R. N. Saicic
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01436G, Communication
The desmethyl analogue of abyssomicin C was synthesized. The synthetic analogue retained its antibacterial activity, whereas its cytotoxicity decreased for three orders of magnitude, as compared to the natural product.
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