Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
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Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01736F, Communication
A rhodium-catalyzed ortho-cyanation of symmetrical azobenzenes is described employing N-cyano-N-phenyl-p-toluenesulfonamide as environmentally friendly cyanide source. The present protocol allows the synthesis of various benzonitirle derivatives in moderate to good yield...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01760A, Paper
A phosphoramidite of a 2ʹ-O,4ʹ-C-methylene-bridged nucleoside, bearing 4-(2,4,6-triisopropylbenzenesulfonyloxy)pyridin-2-one as a nucleobase precursor, was synthesized and introduced into an oligonucleotide. Treatment with various secondary amines after elongating the oligonucleotide on an...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01652A, Review Article
Saponins, amphiphiles of natural origin with numerous biological activities, are widely used in the cosmetic and pharmaceutical industry. Some saponins exhibit relatively selective cytotoxic effects on cancer cells but the...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01446D, Review Article
1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (Tic) is a constrained analog of phenylalanine (Phe). Tic unit has been identified as a core structural element present in several peptide-based drugs and forms an integral part...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01752H, Communication
A variety of ester enolate equivalents are generated in situ and undergo α-allylation in high yields via palladium-catalyzed decarboxylative allylation. The transformations are complete within very short reaction times under...
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01219D, Paper
Three fluorescent probes were rationally designed to discriminate between Cys and GSH/Hcy. Cys and GSH can be differentiated by the naked eye.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01453G, Communication
This paper for the first time presents the addition reactions between amide-derived nucleophiles and CF3-containing N-sulfinyl-imines, with synthetically useful diastereoselectivity and chemical yields.
Devendar Goud Vanga, Mithun Santra, Ashok Keerthi and Suresh Valiyaveettil
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01509F, Communication
A few pyrene-based fluorescent compounds were synthesized using Pd/Cu-catalyzed cross-coupling reaction.
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01346H, Paper
The frustrated Lewis pair (FLP) mediated hydrosilylation of pentafulvenes is described yielding allyl silanes with high regioselectivity in excellent yields. While phenyl substituted allyl silanes undergo B(C6F5)3-mediated rearrangement to vinyl...
Malgorzata Zytek, Joanna Kowalska, Maciej Lukaszewicz, Blazej A Wojtczak, Joanna Zuberek, Aleksandra Ferenc-Mrozek, Edward Darzynkiewicz, Anna Niedzwiecka and Jacek Jemielity
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01579G, Paper
A trimethylguanosine (TMG) cap is present at the 5’ end of several small nuclear and nucleolar RNAs. Recently, it has been reported that the TMG cap is a potential nuclear...
Rachel A. Jones, Yann Thillier, Siva S. Panda, Nicole Rivera Rosario, C. Dennis Hall and Alan R. Katritzky
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01681E, Paper
Synthetic strategies to prepare non-steroidal anti-inflammatory drug–glucosamine bioconjugates.
Ren Xiang Tan, Qi Wu, Nan Jiang, wen bo han, Hui Ming Ge, Zhi Kai Guo, Ng Seik Weng and Yaning Mei
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01494D, Paper
Pseudallescheria boydii residing in the gut of coleopteran (Holotrichia parallela) larve produces four new epipolythiodioxopiperazines (ETPs) boydines A−D (3−6) and two novel sesquiterpene boydenes A (7) and B (10), in...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01646G, Communication
A highly enantioselective intramolecular 6-exo-trig aza-Michael addition was developed to afford chiral 3-substituted 1,2-oxazinanes in high yields (up to 99% yield) and good enantioselectivities (up to 98/2 er). These reactions...
Raquel G. Soengas, Rita Acúrcio and Artur Silva
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01468E, Communication
Indium nitronates were readily prepared from commercially available nitroalkanes by transmetalation of the corresponding lithium nitronates with indium salts. Henry reaction of this indium organometallics with aldehydes afforded β-nitroalkanols in...
Lv Jun-Jiang, Ya-Feng Wang, Jing-Min Zhang, Shan Yu, Hong-Tao Zhu, Dong Wang, Rong-Rong Cheng, Chong-Ren Yang, Min Xu and Ying-Jun Zhang
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01196A, Paper
During the process exploring anti-viral compounds from Phyllanthus species, eight new highly oxygenated bisabolane sesquiterpenoid glycosides phyllaemblicins G1-G8 (1-8) were isolated from Phyllanthus emblica, along with three known compounds, phyllaemblicin...
Pedro Merino, Roberta Majer, Olga Konechnaya, Ignacio Delso, Tomas Tejero, O A Attanasi and Stefania Santeusanio
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01371A, Paper
Asymmetric 1,3-dipolar cycloadditions between 1,2-diaza-1,3-dienes and chiral non-racemic nitrones to give 3-substituted-5-diazenyl isoxazolidines have been studied both experimentally and theoretically. Whereas cyclic nitrones provide complete selectivity for the cycloaddition reaction...
Hsueh-Yun Lee, Li-Ting Wang, Yu-Hsuan Li, Shiow-Lin Pan, Yi-Lin Chen, Che-Ming Teng and Jing-Ping Liou
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00542B, Paper
This study focused on the substitution effect at C7 position of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines. Compound 9, (E)-3-(7-amino-1-(4-methoxyphenylsulfonyl)indolin-5-yl)-N-hydroxyacrylamide, displayed 4- to 14-fold more potent antiproliferative activity than SAHA (1). Notably, 9 possessed specific...
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01719F, Paper
It is shown that many DFT methods correctly predict the stereoselectivity of bipyridine N,N′-dioxide catalyzed alkylation reactions despite predicting the incorrect low-lying transition state structures. A novel explanation of the origin of stereoselectivity in these reactions is also provided.
Nobuya Tsuji, Michael Stadler, Naoya Kazumi, Tsubasa Inokuma, Yusuke Kobayashi and Yoshiji Takemoto
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01678E, Communication
A catalytic asymmetric synthesis of the pentacyclic core of (−)-nakadomarin A was achieved.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01648C, Paper
9-Amino-(9-deoxy)cinchona alkaloid-derived chiral phase-transfer catalysts achieved high yields (92–99%) and excellent enantioselectivities (87–96% ee) in the enantioselective α-alkylation of glycine Schiff base.
Isabella Tavernaro, Sebastian Hartmann, Laura Sommer, Heike Hausmann, Christian Rohner, Martin Ruehl, Anja Hoffmann-Roeder and Sabine Schlecht
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01339E, Paper
The authors present the synthesis of novel MUC1-glycopeptide antigens and their multivalent presentation by gold colloids. Their biological activity was tested in a dot-blot immunoassay experiment.
Yves Blériot, Martine Mondon, Nathalie Fontelle, virginie cendret, jerome desire, George W J Fleet, Terry D Butters, Dominic S Alonzi, gabriele twigg, Shinpei Nakagawa Nakagawa, y hirokami, Isao Adachi, Frédéric Becq, Caroline Norez, johanna bertrand, Jérôme Marrot, Atsushi Kato and ren iwachi
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00325J, Paper
The glycosidase inhibitory properties of synthetic C-alkyl and N-alkyl six-membered iminosugars have been extensively studied leading to therapeutic candidates. The related seven-membered iminocyclitols have been less examined despite the report...
Angeles Bonache, Alessandro Alaimo, Covadonga Malo, Oscar Millet, Alvaro Villarroel and Rosario González-Muñiz
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01338G, Paper
The recombinant Kv7.2 calmodulin (CaM) binding site (Q2AB CaMBD) shows a high tendency to aggregate, thus complicating biochemical and structural studies. To facilitate these studies we have conceived bis-PEG-peptide CaMBD-mimetics...
chandrasekhar challa, Jamsheena Vellekkatt, Jaice Ravindran and Ravi Shankar Lankalapalli
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01829J, Communication
A metal-free one-pot cascade annulation of acyclic substrates dienaminodioate, cinnamaldehydes and allyl amine was achieved for the synthesis of polyfunctional biaryl-2-carbaldehydes. The reaction proceeds at room temperature by a trifluoroacetic...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01790K, Paper
A novel NIS-mediated oxidative cyclization of N-(2-trifluoromethyl-3-alkynyl)hydroxylamines was developed, which provides a facile access to 4-trifluoromethyl -5-acylisoxazoles in 39-91% yields. Various types of commonly used electrophilic halogen source such as...
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