Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
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Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01730G, Paper
Functionalized 2-salicyloylfurans and 2-benzoyl-8H-thieno[2,3-b]indoles were prepared under mild conditions by reaction of 3-halochromones with β-ketoamides and 1,3-dihydroindole-2-thiones, correspondently. The subsequent oxidative cyclization of the products resulted in formation of the...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01535E, Paper
The synthesis of both enantiomers of 4,5-dihydroxy-3-(formyl)cyclopent-2-enone acetonide (5) was accomplished in five steps starting from meso-tartaric acid (6). The key steps involved preparation of the isopropylidene protected 3-[(dimethoxyphosphoryl)methyl]-4,5-dihydroxy-cyclopent-2-enone (9),...
Petra Dunkel, Christine Tran, Thibault Gallavardin, Hamid Dhimane, David Ogden and Peter I. Dalko
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01551G, Paper
Quadrupolar 8-dimethylaminoquinoline-derived photosensitive probes underwent photolysis under UV (365 nm) and NIR (730 nm two-photon (TP)) irradiation conditions.
Enrique Garcia-Espana, Salvador Blasco, Begoña Verdejo, Carla Bazzicalupi, Antonio Bianchi, Claudia Giorgi and Conxa Soriano
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02092H, Paper
Interaction of different hydrophilic (His, Asp, Glu,) and hydrophobic (Ala, Phe, Tyr, Trp) amino acids in water with a scorpiand aza-macrocycle (L1) containing a pyridine group in the ring and...
Ming Yan, Wen-tao Wei, Yu Liu, Lin Miao Ye, Rong Hui Lei and Xue-jing Zhang
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01948B, Paper
The intramolecular coupling of amides and ketones was achieved in the presence of KOt-Bu/DMF. The reaction provided a variety of isoquinolinones in good yields. A reaction mechanism of radical addition...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02143F, Perspective
Multiple reactions in one pot has always been a useful technique for synthetic organic chemists, as it can minimizes the solvent usage, time and the number of purification steps when...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02058H, Paper
Knowledge on the driving force for the hydrophobic effect that partitions antioxidants (AOs) between the oil (O), aqueous (W) and interfacial (I) regions of food emulsions is crucial to predict...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02172J, Communication
Radical cyanomethylation/arylation of arylacrylamides to access oxindoles by acetonitrile as the radical precursor is discribed. This reaction involved dual C–H bonds functionalization, including the sp3 C–H of acetonitrile and the...
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01549E, Communication
This paper describes azidation of indoles with NaN3 and ceric ammonium nitrate (CAN), giving a variety of spirocyclic 2-azido indolines in good yields and moderate diastereoselectivities.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01883D, Communication
Solid phase synthesis of 1,3,4-oxadiazin-5(6R)-one and 1,3,4-oxadiazol-2-one scaffolds from resin-bound acyl hydrazides is described.
Thibaut Denoël, Astrid Zervosen, Christian Lemaire, Bernard Joris, Mireille Hervé, Didier Blanot, Guillermo Zaragoza and André Luxen
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01476F, Paper
The synthesis of modified tripeptides (S)-Ala-γ-(R)-Glu-X, where X = (R,S) or (R,R) diastereomers of α-benzyl or α-(4-azidobenzyl)lanthionine, was carried out.
Krishna P Kaliappan and Kota Ramakrishna
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02136C, Paper
An enantioselective total synthesis of Sch-725674, a unique 14-membered macrolactone, has been accomplished in 13 steps. The step-wise dithiane alkylation served as a strategic step to assemble the northern and...
Xin Huang, Chunling Fu and Shengming Ma
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01975J, Paper
A highly regio- and stereo-selective synthesis of cyclic β-D-glucosides 3 via Pd(0)-catalyzed coupling cyclization of allenyl β-D-glucoside 1 and organic iodides in the yields of 20~38% is reported. After the...
Junyan Han, Dae Hoon Lee, Ching-Hsuan Tung and Daniel Lee
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01981D, Communication
A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells...
Stephanie M. Forget, Alison Jee, Deborah A Smithen, Rajendra Jagdhane, Stephen A Beaton, Raymond T Syvitski, David RJ Palmer and David L Jakeman
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02057J, Paper
Cps2L, a thymidylytransferase, is the first enzyme in Streptococcus pneumoniae L-rhamnose biosynthesis and an antibacterial target. We herein report the evaluation of six sugar phosphate analogues selected to further probe...
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01910E, Paper
Rhodium(II)-catalyzed intramolecular [4+3] cycloadditions of dienyltriazoles have been developed, which enable the efficient synthesis of various fused 2,5-dihydroazepines. Mechanistically, the titled reaction proceeds via an interesting tandem cyclopropanation/aza-Cope rearrangement.
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01895H, Paper
An ammonium picket porphyrin that targets bacterial membranes has been prepared and shown to bind to phosphatidylglycerol (PG), a bacterial lipid, when the lipid was in solution, contained within synthetic...
Alexander V Aksenov, Alexander N Smirnov, Nicolai A Aksenov, Inna V Aksenova, Asiyat S Bijieva and Michael Rubin
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02131B, Communication
A modular approach to 3-substituted 2-quinolones via a cascade annulation reaction between 4-nitroketones and hydrazines has been developed.
Chou-Hsiung Chen, Sivaneswary Genapathy, Peter M. Fischer and Weng C. Chan
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB02107J, Communication
Utilising a chiral auxiliary-facilitated Strecker amino acid synthesis strategy, indole-substituted (S)-tryptophans have been obtained from corresponding indoles; the former in turn were used for the synthesis of a potent antibacterial agent, argyrin and its analogues.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB02079K, Communication
Regioselective S-acylation of coenzyme A is achieved under aqueous conditions using various aliphatic and aromatic carboxylic acids activated as their methyl acyl phosphate monoesters.
Jessy Aziz, Samir Messaoudi, Mouad Alami and Abdallah Hamze
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01727G, Review Article
Recent advances in the preparation and synthetic uses of sulfinic acids and their derivatives are highlighted in this review. They are used as versatile partners in sulfonylative and desulfitative reactions.
Jie Zhang, Dejun Ma, Dawei Du, Zhen Xi and Long Yi
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01873G, Communication
This work reports an efficient reagent for covalent introduction of alkynes into the surface of proteins and viruses under mild conditions.
Yongcheng Wu, Xiaopeng Peng, Bingling Luo, Fuhai Wu, Bo Liu, Fenyun Song, Peng Huang and Shijun Wen
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB02170C, Communication
As the tile reaction shows, an array of dibenzocarbazoles were obtained via dual C–H functionalization of indoles with cyclic diaryliodoniums in a single operation.
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01970A, Communication
A silver-mediated oxidative vinylic C–H bond sulfenylation of enamides was developed. This method is compatible with diaryl and dialkyl disulfides to deliver the biologically precious chalcogenated olefins efficiently. A plausible non-chain radical mechanism was proposed for understanding this novel sulfenylation based on the mechanistic studies.
Chuan-Li Ren, Tao Zhang, Xing-Yong Wang, Tao Wu, Jing Ma, Qing-Qing Xuan, Feng Wei, Hong-Yan Huang, Dong Wang and Li Liu
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB02035A, Paper
An efficient cooperative biscinchona alkaloid and Lewis acid catalytic system was developed in the enantioselective α-alkylation of 2-oxindoles with (3-indolyl)(phenyl)methanols.
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