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Organic & Biomolecular Chemistry

Rapid publication of high quality organic chemistry research
Impact Factor 3.559 48 Issues per Year Indexed in Medline
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Gydo van der Heijden, Jasper Kraakman, Jasper Biemolt, E. Ruijter and Romano Orru
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01813K, Communication
An efficient metal-free procedure for the formal α-carboxylation of primary alcohols has been developed. The method involves a one-pot oxidation/Passerini/hydrolysis sequence and provides access to α-hydroxy acids bearing a broad...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01956K, Communication
We report catalytic, intramolecular hydroacylations of N-allylimidazole-2-carboxaldehydes and N-allylbenzimidazole-2-carboxaldehydes. These exo-selective hydroacylations occur in the presence of a N-heterocyclic carbene catalyst to generate 5,6-dihydro-7H-pyrrolo[1,2-α]imidazol-7-ones and 1,2-dihydro-3H-benzo[d]pyrrolo[1,2-α]imidazol-2-ones in high yields (66-99%)....
bohua long, Jing Zhang, xudong tang and zhengzhi wu
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01783E, Communication
Wewakazole B is a novel cyclodecapeptide with highly potent cytotoxic activity isolated from a sample of M. producens collected from the Red Sea. It contains nine common and three modified...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01939K, Paper
An investigation is reported on the use of the autocatalytic enantioselective Soai reaction, known to be influenced by the presence of a wide variety of chiral materials, as a generic...
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01733A, Paper
A tunable α-hydroxylation/α-chlorination of benzylketone derivatives for the construction of hetero-quaternary units has been developed by iron(III) chloride hexahydrate-mediated selective transformations.
Noriko Saito-Tarashima, Hirotaka Kira, Tomoya Wada, Kazuya Miki, Shiho Ide, Naoshi Yamazaki, Akira Matsuda and Noriaki Minakawa
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01866A, Paper
The chemical probes, comprising Br7C7A and Br3C3A, to investigate RNA–protein interactions were developed.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01679K, Paper
New synthetic strategies to indolocarbazoles have been reported via two-fold Fischer indolization under green conditions using L-(+)-tartaric acid and N,N-dimethyl urea.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01701K, Paper
A concise one-pot synthesis of benzo[c]chromen-6-ones from dichlorocoumarins and butadienes has been achieved, using a photo-initiated formal Diels–Alder reaction, with high overall yields.
Mattia Stucchi, Giovanni Grazioso, Carmen Lammi, Silvia Manara, Chiara Zanoni, A Arnoldi, giordano lesma and alessandra Silvani
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01642A, Communication
Herein we report on the multicomponent synthesis of a novel imidazole-based compound, able to act efficiently as a minimalist β-strand mimic. Biological evaluation proved its ability to impair the LDLR-PCSK9...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01827K, Paper
I2-mediated benzyl C-H functionalization has been developed for synthesis of 2H-indazoles, which features high efficiency, simple condition and no need for metals. Mechanistic experiments and DFT calculations have revealed halogen...
Naoki Shimomura, Yuya Egawa, Ryotaro Miki, Takashi Fujihara, Yoshihiro Ishimaru and Toshinobu Seki
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01695B, Paper
A xanthene derivative containing a borinate moiety emitted a red fluorescence with a high quantum yield. The interaction between the borinate and a sugar molecule induced a fluorescence change based...
Ying Fu, Xingling Zhao, Helmut Hügel, Danfeng Huang, Zhengyin Du, Ke-Hu Wang and Yulai Hu
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01668E, Communication
A magnesium salt promoted synthesis of ketones via tandem nucleophilic addition-Oppenauer oxidation of aldehydes using organozinc chemistry was demonstrated. Magnesium salts concomitantly generated via magnesium metal mediated organohalides zincation exhibit...
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01817C, Paper
Conventional chemical approaches to protein-protein coupling present challenges due to the intrinsic competition between desired interactions of reagents with groups of the protein as well as reactions with water. Biorthogonal...
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01618A, Review Article
Fluorinated diazo compounds were long neglected in organic synthesis. This review discusses the flourishing chemistry of these reagents, ranging from C–H activation to cycloadditions for the synthesis of fluorinated compounds.
Harikrishna Bavireddi, Raghavendra Vasudeva Murthy, Madhuri Gade, Sivakoti Sangabathuni and Raghavendra Kikkeri
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01546H, Paper
Host–guest interactions was used for controlled delivery of the Ru(II)-glycodendrimers into cancer cells to induce cytotoxicity by reacting with the endoplasmic reticulum.
Rohan Yadav, Shani Leviatan Ben-Arye, Balamurugan Subramani, Vered Padler-Karavani and Raghavendra Kikkeri
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01688J, Communication
The synthesis of Neu5Acα(2–6)Gal structural analogs a showed distinct binding patterns with conserved siglecs (hCD22 and mCD22) compared to rapid evolving siglecs (Siglecs -3 & -10).
Iris Pflueger, Coralie Charrat, Carmen Ortiz Mellet, Jose Manuel Garcia Fernandez, Christophe Di Giorgio and Juan Manuel Benito
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01882C, Paper
Exhaustive structure-efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined or polydisperse nature of the formulations. Facial amphiphiles based on rigid cage-type molecular scaffolds offer...
Nataliya Sergeevna Goulioukina, Nikolai Nikolaevich Makukhin, Egor Dmitrievich Shinkarev, Y K. Grishin, Vitaliy A. Roznyatovsky and Irina P Beletskaya
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB01780K, Paper
5-Aryl-substituted pyrazol-3-ylphosphonates have been conveniently synthesized by 1,3-dipolar cycloaddition of 1-formamidovinylphosphonate and aryldiazomethanes under K2CO3/MeOH conditions at room temperature. These pyrazoles are formed in one pot via spontaneous elimination of...
Kaivalya Kulkarni, Boris Miokovic, Matthew Sauder and Graham Murphy
Org. Biomol. Chem., 2016, Accepted Manuscript
DOI: 10.1039/C6OB02074G, Paper
An operationally simple conversion of aromatic aldehyde hydrazones to monofluoromethylated arenes is reported. The hypervalent iodine reagent TolIF2 serves as an oxidant, converting hydrazone derivatives of aromatic aldehydes to the...
Maria Kopsida, Gemma A. Barron, Giovanna Bermano, Paul Kong Thoo Lin and Marie Goua
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01850E, Paper
Chemical and biological properties of novel bisnaphthalimidopropyl derivatives.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01702A, Paper
Diverse pyrenyl–pyrenyl pairs in 10–23 DNAzyme complexes were used to explore the folding of the catalytic core in solution.
Daniele Ragno, Anna Zaghi, Graziano Di Carmine, Pier Paolo Giovannini, Olga Bortolini, Marco Fogagnolo, Alessandra Molinari, Alessandro Venturini and Alessandro Massi
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01868H, Paper
The KOtBu-DMF system promotes benzoin- and Stetter-like reactions of alpha-diketone donors through a double electron-transfer-based mechanism.
Alejandro Torres, Pilar Gutierrez, Ramón Alvarez-Manzaneda, Rachid Chahboun and Enrique Alvarez-Manzaneda
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01640E, Paper
The first syntheses of cytotoxic marine arenarans A and B starting from commercial (−)-sclareol are reported. The oxocene ring of the target compound is formed via ring-closing metathesis. This synthetic strategy is also applicable to the synthesis of other oxocene terpenes.
Mingxing Qian, Elizabeth B. Engler-Chiurazzi, Sara E. Lewis, Nigam P. Rath, James W. Simpkins and Douglas F. Covey
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB01726F, Paper
Estrone and 17β-estradiol are phenolic steroids that are known to be neuroprotective in multiple models of neuronal injury.
Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB02012G, Paper
A copper-catalyzed oxidative cyclization of vinyl azides with benzylic Csp3–H bonds via a tandem dual C–H functionalization process has been developed. This reaction allows access to substituted phenanthridines containing a variety of functional groups.
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71 citations
Donor–acceptor cyclopropane annulations – not just for heterocycles.
DOI: 10.1039/C4OB02117G
Published: 13 Nov 2014
41 citations
This review article covers the main types of gold(i) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.
DOI: 10.1039/C5OB00736D
Published: 19 May 2015
35 citations
The recent advances in the copper-catalysed azide–alkyne cycloaddition (CuAAC) reactions are reviewed.
DOI: 10.1039/C5OB01457C
Published: 31 Jul 2015

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