Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.568 48 Issues per Year Indexed in MEDLINE
 
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Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00080C, Paper
The N[1,3]-sigmatropic shift in the benzidine rearrangement has been studied in depth experimentally with the aid of the density functional theory (DFT) calculations. The designed substituted N,N’-diaryl hydrazines rearrange exclusively...
 
Steven V Ley, Jan Benedikt Metternich, Nikzad Nikbin, Jan Hartwig and Andreas Kirschning
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00662C, Paper
Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00533C, Communication
Addition of a single functional handle to the tricyclic moiety of fluorescein results in asymmetric xanthene dyes. Our synthesis of a new class of asymmetric xanthenes proceeds via an unusual...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00503A, Paper
A general strategy for the synthesis of analogues of radicamine B has been carried out from D-mannitol. This method has been further extended to the synthesis of analogues of codonopsine...
 
Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00622D, Communication
A traceable linker that is potentially applicable to identification of a target protein of bioactive compounds was developed. It enabled not only thiol-induced cleavage of the linker for enrichment of...
 
Hu Ge, Jinggong Liu, Wenxia Zhao, Yu Wang, Qingqing He, ruibo wu, Ding Li and Jun Xu
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00589A, Paper
In the present study, we found that three enzymes, MVK, MDD, and FPPS, in mevalonate pathway (MVP) of cholesterol biosynthesis, can be simultaneously inhibited by two green tea polyphenols (...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00609G, Communication
We describe an efficient synthesis of the methylene-bridged biscarbazole alkaloids bismurrayafoline-A, bismurrayafolinol and chrestifoline B–D using an Ullmann-type coupling at the benzylic position.
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00565A, Communication
Regio- and enantioselective addition of thiols to α,β,γ,δ-unsaturated aldehydes was performed with a resin-supported peptide catalyst. It was shown that a 1,4-adduct was generated mainly at the initial stage of...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00431K, Review Article
Fluorescent probes are essential tools for studying biological systems. The last decade has witnessed a particular interest in the development of two-photon excitable probes, owing to their advantageous features in...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00286E, Paper
Glycosyltransferases are sugar-processing enzymes that require a specific metal ion cofactor for catalysis. In the presence of other ions the catalysis is often impaired. Here, for the first time, the...
 
Nayeon Kim, Se Hun Kwak, Seon-Hyeong Lee, Vinayak Juvekar, Byung Il Lee, Hee-Chul Ahn, Soo-Youl Kim and Young-Dae Gong
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00179F, Paper
In the process of optimization, we developed a novel core skeleton of thieno[3,4-b]pyrazine via the GK-13 compound. These derivatives were shown to inhibit TGase 2 activity in cancer cells. Some...
 
Wataru Setaka, Sayaka Higa and Kentaro Yamaguchi
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00470A, Communication
A molecular gyrotop was synthesized by ring-closing metathesis (RCM) under reflux, indicating that the cage is a thermodynamically controlled product.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00451E, Communication
We found that the catalytic activity of a DNA-hydrolyzing deoxyribozyme could be allosterically regulated by adding short oligonucleotides, and used this technique to construct DNA logic gates.
 
Ana Isabel Sánchez, Ricardo Meneses, José Miguel Minguez, Araceli Nuñez, Rafael R. Castillo, Fabiana Filace, Carolina Burgos, Juan J. Vaquero, Julio Alvarez Builla, Alvaro Cortés-Cabrera, F Gago, Emma Terricabras and Victor Segarra
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00175C, Paper
A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on...
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00423J, Review Article
This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years.
 
Qingwen Gui, Fenglin Dai, Jidan Liu, Peixing Chen, Zhiyong Yang, Xiang Chen and Ze Tan
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00118D, Communication
N-Alkyl isatins were synthesized via oxidative cyclization of N-alkyl 2-bromo or 2-chloro acetanilides in DMSO.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00180J, Paper
An efficient and practical method for effecting a tandem C–H alkenylation/C–O cyclization has been achieved via the C–H functionalization of flavone derivatives.
 
Erwan Le Gall, Stéphane Sengmany, Issa Samb, Sabrina Benakrour, Christopher Colin, Antoine Pignon and Eric Léonel
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C3OB42353K, Paper
The multicomponent synthesis of α,β-disubstituted N-sulfonyl β-amino esters is described.
 
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00101J, Paper
We have developed TP probes for [Zn2+]cyto and [Zn2+]mito, which emit TPEF at widely-separated wavelength regions. The new probes can simultaneously detect [Zn2+]cyto and [Zn2+]mito in live cells, as well as in living tissues by dual-color TPM imaging.
 
Gert Callebaut, Filip Colpaert, Melinda Nonn, Loránd Kiss, Reijo Sillanpää, Karl W. Törnroos, Ferenc Fülöp, Norbert De Kimpe and Sven Mangelinckx
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00243A, Paper
Mannich-type reactions across N-sulfinyl-α-chloroaldimines resulted in syn-stereoselective synthesis of chloroisothreonine derivatives as excellent building blocks.
 
Ramendra Pratap, Surjeet Singh, Pratik Yadav, Satya Narayan Sahu, Ismail Althagafi, Abhinav Kumar, Brijesh Kumar and Vishnu Ji Ram
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00432A, Paper
A new precursor 2-(1-cyano-2,2-bis(methylthio)vinyl)benzonitrile has been synthesized by reaction of 2-cyanomethylbenzonitrile, carbon disulfide and methyl iodide under basic conditions. Reaction of 2-(1-cyano-2,2-bis(methylthio)vinyl)benzonitrile with various functionalized aryl/heteroaryl methyl ketones or acetone...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00184B, Paper
Combining metal-anion coordination and π-π stacking interactions, zinc complex of a novel anthracene-based cyclophane was designed to recognise adenine nucleoside polyphosphates. This complex was found to show selective fluorescence enhancement...
 
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00513A, Paper
A novel synthesis of α, β-unsaturated amides from N,N-disulfonyl ynamides with aldehydes was developed. By utilization of salicylaldehydes, a variety of substituted iminocoumarins were prepared.
 
Jiaxing Hu, Zhihong Deng, xueqiong Zhang, Fanglin Zhang and hua zheng
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00670D, Paper
A convenient one-pot reaction was conducted by mixing bromoacetophenone, functional α, β-unsaturated ketone and potassium hydroxide in tetrahydrofuran at room temperature, ammonium acetate was added and heated to reflux, resulting...
 
Robert F. Anderson, Pooja Yadav, Deepa Patel, Jóhannes Reynisson, Smitha R. Tipparaju, Christopher P. Guise, Adam V. Patterson, William A. Denny, Andrej Maroz, Sujata S. Shinde and Michael P. Hay
Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00236A, Paper
One-electron bioreduction of SN30000, a triazine 1,4-dioxide anticancer drug, forms reactive aryl and carbon-centred radicals.
 
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