Journal cover: Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
 
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Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02670E, Paper
Three-component reaction between RCF2CH2NH2*HCl, NaNO2 and alkynes drastically depends on substituents “R” and “R1”. The reaction gives the fluorinated pyrazoles in high yields when “R” is fluorine atom or fluoroalkyl...
 
Akihiro Taguchi, Kentarou Fukumoto, Yuya Asahina, Akihiro Kajiyama, Shunsuke Shimura, Keisuke Hamada, Kentaro Takayama, Fumika Yakushiji , Hironobu Hojo and Yoshio Hayashi
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00030K, Communication
A new solid-phase disulfide ligation method is developed to prepare a disulfide peptide from two types of Cys-containing peptide fragments with minimum purification steps. In combination with the subsequent intramolecular...
 
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00020C, Paper
A facile, efficient, single-step protocol for the synthesis of difluoromethyl enol ethers derivatives by O-difluoromethylation of 1,3-diones via in situ generation of difluorocarbene from ClCF2CO2Et has been developed. The functional...
 
Deborah A Smithen, Stephanie M. Forget, Nicole E McCormick, Raymond T Syvitski and David L Jakeman
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02583K, Paper
A series of polyphosphate containing sugar nucleotide analogues were synthesized and evaluated as bisubstrate inhibitors of α-D-glucose 1-phosphate thymidylyltransferase Cps2L, the first enzyme in Streptococcus pneumoniae L-rhamnose biosynthesis, and a...
 
Ravindra Pathak, Benjamin Dobson, Nandita Ghosh, Khalid Ageel, Madeha Alshawish, Rungroj Saruengkhanphasit and I Coldham
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02582B, Paper
An efficient synthetic approach to the core structure of the manzamine alkaloids is reported, particularly in relation to incorporating a one-carbon unit in ring B from which the aldehyde in...
 
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00147A, Paper
Blocking the function of both heat shock protein 90 and 70 (Hsp90 and Hsp70) simultaneously limits these chaperones’ cytoprotective effects on cancer cells. The unique phenotype associated with modulating Hsp90’s...
 
Meder Kamalov, Paul W. R. Harris, Christian G. Hartinger, Gordon M. Miskelly, Garth J. S. Cooper and Margaret A. Brimble
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02536A, Paper
The strong interaction between advanced glycation end-products and Cu(II) ions has been revealed using site-specifically glycated collagenous peptides.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02574A, Paper
Pd-catalyzed asymmetric intramolecular allylic alkylation reaction of phenols was developed, affording C4 substituted tetrahydroisoquinolines in moderate to excellent yields, enantioselectivity and regioselectivity.
 
Kuruppanthara N. Vijayadas, Amol S. Kotmale, Shridhar H. Thorat, Rajesh G. Gonnade, Roshna V. Nair, Pattuparambil R. Rajamohanan and Gangadhar J. Sanjayan
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02438A, Paper
This manuscript depicts an intriguing example of H-bonding reversal upon introduction of a sulfonamide linkage at the N-terminus of a synthetic reverse-turn peptide.
 
Miguel M. Santos, Igor Marques, Sílvia Carvalho, Cristina Moiteiro and Vítor Félix
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02283A, Paper
The binding affinity of a dichlorocalix[2]arene[2]triazine based bis-urea azamacrocycle was investigated towards a wide range of bio-relevant dicarboxylate anions by a combination of 1H NMR titrations in CDCl3 and molecular dynamics simulations.
 
Kseniya N Sedenkova, Evgenia V Dueva, Elena B. Averina, Y K. Grishin, Dmitry I. Osolodkin, Liubov I Kozlovskaya, Vladimir A Palyulin, Evgenii N Savelyev, Boris S Orlinson, Ivan A Novakov, Gennady M Butov, Tamara S Kuznetsova, Galina G Karganova and Nikolay S. Zefirov
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02649G, Paper
Tick-borne encephalitis virus (TBEV) belonging to Flavivirus genus causes severe infection in humans. The search for therapeutically relevant compounds targeting TBEV requires the exploration of novel chemotypes. A versatile synthesis...
 
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02053G, Paper
Porphyrins carrying either a primary alcohol, tertiary alcohol or primary bromide linker group were allowed to react with the surface silanol groups on silicate glass thermally at 80-240 oC to...
 
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02663B, Paper
Uvacalols are novel carbasugars belonging to the family of C7-cyclitols, and are isolated from the roots of the medicinal plant, Uvaria calamistrata. In this study, we report the first syntheses...
 
Marco Caricato, Arnaud Delforge, Davide Bonifazi, Daniele Dondi, Andrea Mazzanti and Dario Pasini
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02643H, Paper
A chiral, multivalent macrocycle assembles upon metal–pyridine coordination into ordered nanostructures in solution and on surfaces.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00009B, Communication
A catalytic metal-free hydrogenation of naphthylamines using B(C6F5)3 was achieved under mild conditions for the first time to furnish tetrahydronaphthylamines in high yields.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02654C, Paper
From themed collection Supramolecular Chemistry in Water
A poly[(2-ethyl-2-oxazoline)-ran-(2-nonyl-2-oxazoline)] random copolymer was synthesized and its thermoresponsive behavior in aqueous solution modulated by the addition of different supramolecular host molecules.
 
Hannelore Rücker, Nafisah Al-Rifai, Anne Rascle, Eva Gottfried, Lidia Brodziak-Jarosz, Clarissa Gerhäuser, Tobias P. Dick and Sabine Amslinger
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02301C, Paper
Boosting the alkylation power of chalcones creates new anti-inflammatory agents. Thus NF-κB-dependent proteins are inhibited and Nrf2-dependent ones activated. The activity enhancement relies solely and very effectively on the α-substituent of the α,β-unsaturated carbonyl unit.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02593H, Paper
A dithioacetal-containing triarylborane behaves as a promising ratiometric bifunctional fluorescence probe to detect Hg2+ and F simultaneously.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02144D, Paper
Two symmetrical C7,C8-acetylenic carotenoids have been stereoselectively prepared using a bi-directional Horner–Wadsworth–Emmons condensation of the C10-dialdehyde and C15-phosphonates.
 
Vemu Nagaraju, Dalovai Purnachander, N. S. V. M. Rao Mangina, Surisetti Suresh, Balasubramanian Sridhar and Galla V. Karunakar
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01578A, Paper
Synthesis of dihydropyridinones was achieved by reaction of β-enaminones with acetylene dicarboxylates without using transition metal/catalyst.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02369B, Paper
Four chiroptical methods, i.e. electronic circular dichroism (ECD), optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and Raman optical activity (ROA) were employed to discover a set of the most probable conformations of (−)-Oseltamivir in solution.
 
Chong Qian, Mingyang Liu, Guanghui Hong, Pengchong Xue, Peng Gong and Ran Lu
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02612H, Paper
New organogelators based on triphenylamine functionalized β-diketones and their difluoroboron complexes were synthesized.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02203C, Communication
A facile and efficient synthetic protocol was established for the construction of novel tri- and tetra-cyclic pyrrolo/pyrrolizinoquinoline architectures via an intramolecular [3 + 2] cycloaddition reaction strategy.
 
Fabio Doro, Cinzia Colombo, Chiara Alberti, Daniela Arosio, Laura Belvisi, Cesare Casagrande, Roberto Fanelli, Leonardo Manzoni, Emilio Parisini, Umberto Piarulli, Elena Luison, Mariangela Figini, Antonella Tomassetti and Monica Civera
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02538E, Communication
Peptidomimetic 3 mimicking the DWVI adhesive sequence of the cadherin EC1 domain inhibits cadherin-mediated adhesion in epithelial ovarian cancer cells.
 
Marco Hellmert, Andreas Müller-Schiffmann, Max Sena Peters, Carsten Korth and Thomas Schrader
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02411G, Paper
From themed collection Supramolecular Chemistry in Water
A His-tagged antibody is combined with an NTA-β-sheet breaker and displays a striking increase in Aβ affinity.
 
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