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Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.
Impact Factor 3.487 48 Issues per Year Indexed in MEDLINE
 
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N. Dyubankova, E. Sochacka, K. Kraszewska, B. Nawrot, P. Herdewijn and E. Lescrinier
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00164A, Paper
NMR studies of the D-arm of tRNAiMet revealed the crucial role of dihydrouridine nucleoside in folding of the oligo.
 
Herman S. Overkleeft, Nora Liu, Sascha Hoogendoorn, Bas van der Kar, Allard Kaptein, Tjeerd Barf, Christoph Driessen, Dmitri Filippov, Gijsbert A van der Marel and Mario van der Stelt
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00474H, Paper
Ibrutinib is a covalent and irreversible inhibitor of Bruton’s tyrosine kinase (BTK) and has been approved for the treatment of haematological malignancies, such as chronic lymphocytic leukaemia, mantle cell lymphoma...
 
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00502G, Communication
We disclosed a palladium-catalyzed carbonylative Sonogashira reaction with aryl triazenes and alkynes as substrates and methanesulfonic acid as the additive. A series of α,β-ynones were synthesized by this alternative procedure....
 
Tohasib Yusub Chaudhari, Asik Hossian, Manash Kumar Manna and Ranjan Jana
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00235D, Communication
Chemo-, regio-, and stereoselective Heck–Matsuda arylation of allylic and cinnamyl alcohols with inexpensive and readily available arenediazonium salts is reported.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00289C, Paper
Dendrimer-encapsulated Pd nanoparticles anchored within continuous flow microreactors are efficient for C–C cross-coupling reactions. This is witnessed by the good catalytic performance for the Heck–Cassar and Suzuki–Miyaura couplings.
 
Rémy Dureau, Maxime Gicquel, Isabelle Artur, Jean-Paul Guégan, Bertrand Carboni, Vincent Ferrières, Fabienne Berrée and Laurent Legentil
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00296F, Paper
The strong interaction of an octyl chain with M. smegmatis cells was paired with high specificity of the galactofuranose ring against mycobacteria growth.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00081E, Paper
A revision of the analytical protocol for the GC–MS determination of free or 1,7-lactonized sialic acids as heptafluorobutyrates is reported.
 
Yanxin J. Wang, D. Miklos Szantai-Kis and E. James Petersson
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00224A, Perspective
To make thioamide protein folding experiments applicable to full-sized proteins, our laboratory has used a combination of native chemical ligation of thiopeptide fragments, unnatural amino acid mutagenesis to install fluorophore partners in expressed protein fragments, and chemoenzymatic protein modification to render these expressed protein ligations traceless.
 
Mohammad S. Hossain, Cuong Q. Le, Ebenezer Joseph, Toan Q. Nguyen, Kayunta Johnson-Winters and Frank Foss
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00365B, Communication
F420 and FO are phenolic 5-deazaflavin cofactors that complement nicotinamide and flavin redox cofactors in biochemical oxidoreductases and photocatalytic systems. Specifically, these 5-deazaflavins lack the single electron reactivity of riboflavin-derived...
 
Kana M Sureshan, Amol Madhukar Vibhute, Colin W Taylor and Vera Konieczny
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00440C, Paper
IP3 receptors are channels that mediate release of Ca2+ from the intracellular stores of cells stimulated by hormones or neurotransmitters. Adenophostin A (AdA) is the most potent agonist of IP3...
 
Patrique Nunes, Goreti Ribeiro Morais, Elisa Palma, Francisco Silva, Maria Cristina Oliveira, Vera F. C. Ferreira, Filipa Mendes, Lurdes Gano, Hugo Vicente Miranda, Tiago F. Outeiro, Isabel Santos and Antonio Paulo
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00124B, Paper
Merging classical organic anticancer drugs with metal-based compounds in one single molecule offers the possibility of exploring new approaches for cancer theranostics, i.e., the combination of diagnostic and therapeutic modalities....
 
Vellaisamy Sridharan, Perumal Vinoth, Thavaraj Vivekanand, Padmakar A. Suryavanshi, J. Carlos Menendez and Hiroaki Sasai
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00458F, Paper
A catalytic, atom-economical, domino 5-endo-dig cyclization-intramolecular olefin insertion sequence was developed under mild conditions. Aryl alkynoic acids bearing a tethered enone partner afforded the indeno[1,2-b]furan-2-ones, the core skeleton present in...
 
Jaideep B Bharate, Sheenu Abbat, Rohit Sharma, Prasad. V. Bharatam, Ram A Vishwakarma and Sandip Bibishan Bharate
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00419E, Paper
A cobalt acetylacetonate catalyzed oxidative diketonation of alkynes via C(sp)-H bond functionalization has been described. The reaction involves a free-radical mechanism, wherein the phenyl radical formed from phenyl hydrazine couples...
 
Diego Nuñez-Villanueva, Maria teresa García-López, Mercedes Martín-Martínez and Rosario González-Muñiz
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00429B, Paper
A suitably protected Orn-derived (3S,4S)-β-lactam was used as common intermediate in the synthesis of conformationally constrained (3S,4S)-2-oxoazepane α,α- and (2S,3S)-2-oxopiperidine-β2,3,3-amino acid derivatives. Compared to the alternative procedures using an N-p-methoxybenzyl...
 
M. Van Overtveldt, T. S. A. Heugebaert, I. Verstraeten, D. Geelen and C. V. Stevens
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00137D, Paper
A 4-step synthesis towards phosphonic pyrabactin analogues is presented. Via a stomatal closure and germination assay, their ability to selectively induce the ABA-signaling pathway was demonstrated.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02675F, Paper
The first example of palladium-catalyzed coupling between benzyl sulfonates and arylboronic acids was reported.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00431D, Paper
Rhodium/chiral diene complex-catalyzed asymmetric addition of arylboronic acids to cyclic ketimines having an ester group proceeded to give the corresponding α-amino acid derivatives in high yields with high enantioselectivity.
 
Rosa Adam, Pablo Bilbao-Ramos, Belén Abarca, Rafael Ballesteros, M. Eugenia González-Rosende, M. Auxiliadora Dea-Ayuela, Francisco Estevan and Gloria Alzuet-Piña
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00280J, Paper
Triazolopyridopyrimidine compounds behave as DNA photocleavers through both type I and type II mechanisms.
 
Jian-Fei Xue, Shao-Fang Zhou, Ye-Ye Liu, Xiangqiang Pan, Jian-Ping Zou and Olayinka Taiwo Asekun
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00404G, Paper
Mn(OAc)3-mediated tandem phosphonyl radical addition to β-nitrostyrenes followed by denitration to form (E)-2-alkenyl phosphonates is described.
 
Praewpan Katrun, Sornsiri Hlekhlai, Jatuporn Meesin, Manat Pohmakotr, Vichai Reutrakul, Thaworn Jaipetch, Darunee Soorukram and Chutima Kuhakarn
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00417A, Paper
A novel and expedient method for the decarboxylative sulfonylation of β-aryl-α,β-unsaturated carboxylic acids to their (E)-vinyl sulfones is described.
 
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00253B, Paper
A regio- and stereoselective intramolecular direct aldol reaction of 2,7-diketones derived from carbohydrates has been developed to construct cycloalkanones 7, which were dehydrated to obtain heavily oxygenated cycloalkenones 8.
 
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00477B, Paper
Oligonucleotides (ONs) modified with locked nucleic acid (LNA) are widely used in the fields of therapeutics, diagnosis, and nanotechnology. There has been significant effort towards developing LNA analogues bearing modified...
 
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00528K, Paper
The syntheses of various N-protected aromatic-ring fused pyrrole-2-carboxylate derivatives have been accomplished using mild one-pot Horner-Wadsworth-Emmons olefination and Cu-catalyzed intramolecular N-arylation reactions. The optimized mild one-pot reaction conditions of various...
 
Maria Jose Pineda de las Infantas, Sara Torres-Rusillo, Juan Diego Unciti-Broceta, Pablo Fernandez-Rubio, Angelica Luque-Gónzalez, Miguel Angel Gallo, Ignacio J Molina, Asier Uniciti Broceta and Juan J. Diaz-Mochon
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00230C, Paper
A 18-member library of 6,8,9-poly-substituted purines was prepared from pyrimidines, primary alcohols and N,N-dimethylamides under basic conditions via a novel one-pot synthetic pathways controlled by amide sizes and the novel...
 
xiaochen ren, chunyan he, yingle feng, Yonghai Chai, weiping chen, shengyong zhang and Wei Yao
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00298B, Paper
An efficient method was developed to synthesize the ferrocene-based bifunctional amine-thioureas bearing multiple hydrogen-bonding donors. Asymmetric Michael addition of acetylacetone to nitroolefins catalyzed by these novel bifunctional catalysts afford the...
 
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