Journal cover: Metallomics


Global approaches to metals in the biosciences
Impact Factor 4.099 12 Issues per Year Indexed in MEDLINE
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Metallomics, 2014, Accepted Manuscript
DOI: 10.1039/C4MT00046C, Paper
Metal/N-heterocyclic carbene (NHC) complexes hold great opportunities for the development of novel antitumor metallodrugs. Herein, four Ag(I) and Au(I) complexes containing NHCs derived from cyclophanes have been prepared and characterized...
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00058G, Paper
Examining the relationship between zinc, calcium, iron and copper in isolated sub-RPE deposits highlighted the diverse role these metals might play in conditions like age-related macular degeneration.
Stefan Grumbein, Madeleine Opitz and Oliver Lieleg
Metallomics, 2014, Accepted Manuscript
DOI: 10.1039/C4MT00049H, Paper
Many problems caused by bacterial biofilms can be traced back to their high resilience towards chemical perturbations and their extraordinary sturdiness towards mechanical forces. However, the molecular mechanisms that link...
Claire Weekley, Anu Shanu, Jade B. Aitken, Stefan Vogt, Paul Kenneth Witting and Hugh Harris
Metallomics, 2014, Accepted Manuscript
DOI: 10.1039/C4MT00088A, Paper
Dietary selenium has been implicated in the prevention of cancer and other diseases, but its safety and efficacy is dependent on the supplemented form and its metabolites. In this study,...
Mireille Chevallet, Louis Jarvis, Amélie Harel, Sylvie Luche, Sébastien Degot, Violaine Chapuis, Guylain Boulay, Thierry Rabilloud and Alexandre Bouron
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00028E, Paper
The canonical transient receptor potential 6 (TRPC6) protein is a non-selective cation channel able to transport essential trace elements like iron (Fe) and zinc (Zn) through the plasma membrane.
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00045E, Paper
The molecular structure of the electron-transfer protein cytochrome c552 from a cold-adapted, hydrocarbon-degrading marine bacterium is reported (PDB: 4O1W).
Pavlo Holenya, Suzan Can, Riccardo Rubbiani, Hamed Alborzinia, Anja Jünger, Xinlai Cheng, Ingo Ott and Stefan Wölfl
Metallomics, 2014, Accepted Manuscript
DOI: 10.1039/C4MT00075G, Paper
Due to their broad spectrum of biological activity and antiproliferative effect on different human cancer cell lines, gold compounds have been in the focus of drug research for many years....
Victor Hermand, Emilie Julio, Francois Dorlhac de Borne, Tracy Punshon, Felipe Klein Richachenevsky, Arnaud Bellec, Françoise Gosti and Pierre Berthomieu
Metallomics, 2014, Accepted Manuscript
DOI: 10.1039/C4MT00071D, Paper
Cadmium (Cd) is a non-essential heavy metal, which is classified as a “known human carcinogen” by the International Agency for Research on Cancer (IARC). Understanding the mechanisms controlling Cd distribution...
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00064A, Critical Review
Zinc-responsive transcription factors play a central role in zinc homeostasis by regulating zinc transporter and metallothionein gene expression.
S. Meyer, M. Matissek, S. M. Müller, M. S. Taleshi, F. Ebert, K. A. Francesconi and T. Schwerdtle
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00061G, Paper
Arsenic-containing hydrocarbons exert strong toxic effects in cultured human cells.
Rosario Musacco-Sebio, Nidia Ferrarotti, Christian Saporito-Magriñá, Jimena Semprine, Julián Fuda, Horacio Torti, Alberto Boveris and Marisa G. Repetto
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00378G, Paper
Increased cytosolic levels of Fe2+, Cu+ and H2O2 are central to the hypothesis that Fe and Cu toxicities are mediated by OH˙ formation and oxidative damage due to phospholipids and proteins oxidation.
Xuesong Sun, Qing-Yu He, Nanjie Wang, Jing Zhang, Xiao-yan YANG, Nan Li, Liang Zhang, Junlong Han, Kun Cao, Zhong Guo and Guangchuang Yu
Metallomics, 2014, Accepted Manuscript
DOI: 10.1039/C4MT00027G, Paper
Streptococcus pyogenes is a major human bacterium with high pathogenicity. Heme is a major source of iron that plays a critical role in bacterial survival and virulence. In this study,...
Laura Marie Plum, Anne Brieger, Gabriela Engelhardt, Silke Hebel, Andreas Nessel, Marcus Arlt, Jennifer Kaltenberg, Ulrich Schwaneberg, Michael Huber, L. Rink and Hajo Haase
Metallomics, 2014, Accepted Manuscript
DOI: 10.1039/C3MT00197K, Paper
Free zinc ions (Zn2+) participate in several signaling pathways. Aim of the present study was to investigate a potential involvement of Zn2+ in the PI3K/Akt pathway of interleukin (IL)-2 signaling...
Metallomics, 2014, Accepted Manuscript
DOI: 10.1039/C4MT00054D, Paper
Brain iron accumulation is supposed to play a central role in neurodegeneration by inducing oxidative stress. Currently it is unknown to which extent iron entering brain over lifetime exchanges with...
Lei He, Xuesong Wang, Cong Zhao, Dengsen Zhu and Weihong Du
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00021H, Paper
Inhibition of human amylin fibril formation by insulin-mimetic vanadium complexes.
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00041B, Perspective
Highlighting what is known and not known about the co-regulation of metal acquisition and alkane oxidation in the marine environment.
W. Andrew Lancaster, Angeli Lal Menon, Israel Scott, Farris L. Poole, Brian J. Vaccaro, Michael P. Thorgersen, Jil Geller, Terry C. Hazen, Richard A. Hurt, Steven D. Brown, Dwayne A. Elias and Michael W. W. Adams
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00050A, Paper
The metals assimilated by two soil microorganisms varied dramatically although their genome sequences revealed a comparable number of predicted metalloproteins.
C J Carrano, Kyoko Yarimizu, Geraldine Polido, Astrid Gaerdes, Melissa Carter and Mary Hibbern
Metallomics, 2014, Accepted Manuscript
DOI: 10.1039/C4MT00053F, Paper
Evidence is increasing for a mutualistic relationship between phytoplankton and heterotrophic marine bacteria. It has been proposed that bacteria producing photoactive iron binding compounds known as siderophores could play an...
Niels-Peter Becker, Janine Martitz, Kostja Renko, Mette Stoedter, Sandra Hybsier, Thorsten Cramer and Lutz Schomburg
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00004H, Paper
In hypoxia, selenoprotein biosynthesis becomes redirected in favor of the essentially needed GPX4, thereby preventing the fast activation of cell-death pathways.
A. I. Karsisiotis, C. F. Damblon and G. C. K. Roberts
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00066H, Critical Review
β-Lactamases inactivate the important β-lactam antibiotics by catalysing the hydrolysis of the β-lactam ring, thus. One class of these enzymes, the metallo-β-lactamases, bind two zinc ions at the active site and these play important roles in the catalytic mechanism.
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00033A, Paper
Systematical modifications of traditional gel electrophoresis have yielded a method to separate soluble proteins with high resolution while retaining metal cofactors and enzymatic function.
Alan Rembach, Dominic J. Hare, James D. Doecke, Samantha C. Burnham, Irene Volitakis, Christopher J. Fowler, Robert A. Cherny, Catriona McLean, Rudolf Grimm, Ralph Martins, David Ames, Colin L. Masters, Ashley I. Bush and Blaine R. Roberts
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00060A, Communication
Serum zinc decreases with age.
Zuandi Luo, Lianling Yu, Fang Yang, Zhennan Zhao, Bo Yu, Haoqiang Lai, Ka-Hing Wong, Sai-Ming Ngai, Wen-Jie Zheng and Tianfeng Chen
Metallomics, 2014, Accepted Manuscript
DOI: 10.1039/C4MT00044G, Paper
TrxR is a NADPH-dependent selenoenzyme upregulated in a number of cancers. It plays a pivotal role in cancer progression and represents an increasingly attractive target for anticancer drugs. The limitations...
Bryan J. McCranor, Henryk Szmacinski, Hui Hui Zeng, Andrea K. Stoddard, Tamiika Hurst, Carol A. Fierke, J. R. Lakowicz and Richard B. Thompson
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00305A, Paper
Copper is a required trace element that plays important biological roles. Fluorescence-based biosensors for Cu(II) enable the rapidly exchangeable form of the metal ion to be imaged in living cells.
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00034J, Paper
Potent organometallic osmium complex accumulates in cellular membranes, induces mitochondrial stress and S-phase arrest in non-small cell lung cancer cells.

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