Journal cover: Metallomics


Global approaches to metals in the biosciences
Impact Factor 3.978 12 Issues per Year Indexed in MEDLINE
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Anikó Czene, Eszter Tóth, Eszter Németh, Harm Otten, Jens-Christian N. Poulsen, Hans E. M. Christensen, Lubomír Rulíšek, Kyosuke Nagata, Sine Larsen and Béla Gyurcsik
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00195H, Paper
The crystal structure of a colicin E7 metallonuclease mutant complemented by QM/MM calculations suggests an alternative catalytic mechanism of Zn2+-containing HNH nucleases.
Jimena Semprine, Nidia Ferrarotti, Rosario Musacco-Sebio, Christian Saporito-Magriñá, Julián Fuda, Horacio Torti, Mauricio Castro-Parodi, Alicia Damiano, Alberto Boveris and Marisa G. Repetto
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00159A, Paper
The response of brain antioxidant system to the oxidative stress following Fe and Cu overloads involves: antioxidant consumption and an adaptive increase in antioxidant enzyme activities and protein expression.
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00179F, Tutorial Review
We discuss the development and application of genetically-encoded FRET sensors as attractive tools to study intracellular Zn2+ homeostasis and signaling.
Paulina Gonzalez, Viviana C. P. da Costa, Kimberly Hyde, Qiong Wu, Onofrio Annunziata, Josep Rizo, Giridhar Akkaraju and Kayla N. Green
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00161C, Paper
A hybrid molecule composed of lipoic acid and the metal binding cyclen core are shown to protect cells from damaging copper ions and amyloid proteins via multi-modal pathways that involve antioxidant capacity and control of metal-ions.
Manikantan Syamala Kiran, Natarajan Duraipandy, Rachita Lakra, srivatsan kunnavakkam vinjimur, Purnasai Korrapati and Debasis Samanta
Metallomics, 2014, Accepted Manuscript
DOI: 10.1039/C4MT00165F, Paper
Plumbagin is a nutraceutical with potent anti-cancer activity. However, the therapeutic efficacy of plumbagin is overshadowed by lack of sensitivity and selectivity towards cancer cells. The present study evaluated the...
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00185K, Paper
Insight into the organoarsenic metabolism of Alkaliphilus oremlandii OhILAs by comprehensive proteomic analysis.
Giovanni DalCorso, Anna Manara, Silvia Piasentin and Antonella Furini
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00173G, Minireview
Plants are challenged by metal ion concentrations and have evolved mechanisms to cope with this. Beneficial elements help plants in this job, alleviating stress symptoms.
Jiating Zhao, Yufeng Li, Yunyun Li, Yuxi Gao, Bai Li, Yi Hu, Yuliang Zhao and Zhifang Chai
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00170B, Paper
Selenium can modulate inorganic mercury/methylmercury uptake and distribution in rice plants, and finally inhibit mercury accumulation in the rice grains.
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00158C, Paper
Arene ruthenium(II) complex can be used as a potential dual functional agent to inhibit the growth and metastasis of breast cancer cells through inducing S-phase arrest and blocking the formation of invadopodia.
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00097H, Paper
Dysregulation of metal homeostasis has been perceived as one of the key factors in the progression of neurodegeneration.
Mingfeng Yu, Timothy M. Ryan, Samantha Ellis, Ashley I. Bush, James A. Triccas, Peter J. Rutledge and Matthew H. Todd
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00122B, Paper
Novel neuroprotective peptide–macrocycle conjugates exhibit complex, multifaceted structure–activity relationships in their interactions with amyloid β.
Johan Estellon, Sandrine Ollagnier de Choudens, Myriam Smadja, Marc Fontecave and Yves Vandenbrouck
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00156G, Paper
Here we provide a bioinformatic strategy for detecting iron–sulfur cluster metalloproteins with a higher accuracy rate than existing tools. The computational model applied to over 550 prokaryotic genomes generated an unprecedent data base available through a dedicated website.
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00149D, Paper
Zinc finger metallome demonstrates large variation in stability.
Eman A. Akam, Tsuhen M. Chang, Andrei V. Astashkin and Elisa Tomat
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00153B, Paper
Reduction of a disulfide linkage switches on an antiproliferative thiosemicarbazone chelator. The resulting low-spin Fe(III) complex is identified in cancer cells and its intracellular redox behavior and toxicity are examined.
Giuseppe D. Ciccotosto, Simon A. James, Matteo Altissimo, David Paterson, Stefan Vogt, Barry Lai, Martin D. de Jonge, Daryl L. Howard, Ashley I. Bush and Roberto Cappai
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00176A, Paper
The intracellular metal concentration and distribution for Cu, Zn, Fe and Ca were determined by X-ray fluorescence microscopy (XFM) in cultured cortical neurons and were found to be altered in mice lacking APP and APLP2 expression.
Zhen Zhang, Liying Qiu, Chen Lin, Hong Yang, Haiying Fu, Rui Li and Y. James Kang
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00052H, Paper
HIF-1 mediated expression of BNIP3 by cobalt chloride is Cu-dependent, but the expression of IGF-2 is Cu-independent.
Esther Humann-Ziehank, Anne Menzel, Petra Roehrig, Barbara Schwert, Martin Ganter and Isabel Hennig-Pauka
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00148F, Paper
Experimental bacterial lung infection affects trace elements in blood and liver tissue.
Aviva Levina, Andrew I. McLeod, Lauren E. Kremer, Jade B. Aitken, Christopher J. Glover, Bernt Johannessen and Peter A. Lay
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00146J, Paper
X-ray absorption near edge structure (XANES) speciation of vanadium pro-drugs in artificial digestive juices has delineated biotransformations after oral administration.
Rosa F. Brissos, Ester Torrents, Francyelli Mariana dos Santos Mello, Wanessa Carvalho Pires, Elisângela de Paula Silveira-Lacerda, Ana B. Caballero, Amparo Caubet, Chiara Massera, Olivier Roubeau, Simon J. Teat and Patrick Gamez
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00152D, Paper
Copper complexes from Schiff-base ligands show high cytotoxicity against diverse cancer cell lines, with IC50 values down to 0.23 μM.
Alessandro Sinopoli, Antonio Magrì, Danilo Milardi, Matteo Pappalardo, Pietro Pucci, Angela Flagiello, Jeremy J. Titman, Vincenzo Giuseppe Nicoletti, Giuseppe Caruso, Giuseppe Pappalardo and Giuseppe Grasso
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00130C, Paper
Copper(II) coordination to human amylin has an influence on the aggregation and cytotoxic features of the polypeptide. Comparative investigations, carried out on a model peptide encompassing the 17–29 aminoacid region of amylin containing the putative metal binding site, support the non-fibrillar nature of the copper(II) complexes.
Júlio César Santos Júnior, Pedro Carlos Mollo Filho, Ruggero Bernardo Felice Guidugli, Marcos Nogueira Eberlin, Gustavo de Souza Pessôa, Elidiane Gomes da Silva, Marco Aurélio Zezzi Arruda and Nelci Fenalti Höehr
Metallomics, 2014, Advance Article
DOI: 10.1039/C3MT00373F, Paper
Evaluation of metals and (metallo)proteins in vitreous humor samples at different post-mortem intervals.
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00162A, Paper
A tracer experiment is carried out with transgenic T (variety M 7211 RR) and non-transgenic NT (variety MSOY 8200) soybean plants to evaluate if genetic modification can influence the uptake and translocation of Fe.
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00160E, Paper
Arsenite-induced AFD neuron damage via oxidative stress.
Suzanne Angeli, Tracy Barhydt, Ross Jacobs, David W. Killilea, Gordon J. Lithgow and Julie K. Andersen
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00168K, Paper
Mn feeding induces altered metal composition and degrades protein homeostasis in C. elegans.
Ciro Cubillas, Pablo Vinuesa, Maria Luisa Tabche, Araceli Dávalos, Alejandra Vázquez, Ismael Hernández-Lucas, David Romero and Alejandro García-de los Santos
Metallomics, 2014, Advance Article
DOI: 10.1039/C4MT00135D, Paper
Phylogenetic and functional analysis of a novel Mn2+/Fe2+-CDF transporter.

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