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MedChemComm

Broadening the field of opportunity for medicinal chemists. Official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.626 12 Issues per Year
 
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Sören Krawczyk, Christiane Baumert, Joséf Molnár, Christoph Ritter, Jens Höpner, Charlotte Kloft and Andreas Hilgeroth
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00506F, Concise Article
Novel non-substrate modulators of the transmembrane efflux pump P-gp have been profiled as nontoxic and mdr reversing agents.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00560K, Concise Article
3D binding interactions of 7a (magenta-colored carbons) and the co-crystallized ligand (cyan-colored carbons) with the active site amino acids of CHK1.
 
Chun Loong Ho, In Young Hwang, Kathy Loh and Matthew Wook Chang
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00537F, Concise Article
From themed collection New Talent: Asia-Pacific
An improved method of recombinant human lactoferrin (hLF) expression in rich culture medium is demonstrated using macroporous microencapsulation.
 
Arnab Bhattacharyya, Akanksha Dixit, Koushambi Mitra, Samya Banerjee, Anjali A. Karande and Akhil R. Chakravarty
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00425F, Concise Article
BODIPY-appended copper(II) complexes of curcumin show a remarkable PDT effect in visible light in HeLa cells via apoptosis with mitochondrial localization.
 
Santosh Kumar Prajapti, Shweta Shrivastava, Umesh Bihade, Ajay Kumar Gupta, V. G. M. Naidu, Uttam Chand Banerjee and Bathini Nagendra Babu
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00525B, Concise Article
Novel Δ2-isoxazoline fused cyclopentane derivatives have been synthesized and evaluated for their antimicrobial and anticancer activities.
 
Yin Chen, Yu Lan, Xudong Cao, Xiangqing Xu, Juecheng Zhang, Minquan Yu, Xin Liu, Bi-Feng Liu and Guisen Zhang
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00578C, Concise Article
A series of amide derivatives of benzisoxazole has been synthesized and the target compounds evaluated for atypical antipsychotic activity in vitro and vivo.
 
Annamaria Panico, Rosanna Maccari, Venera Cardile, Sergio Avondo, Lucia Crascì and Rosaria Ottanà
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00556B, Concise Article
2-Thioxo-4-thiazolidinone derivatives active as aldose reductase inhibitors were able to control key inflammatory/degenerative events induced by IL-1β in human chondrocytes, appearing to be promising candidates in the search for novel anti-inflammatory agents.
 
Quan Van Vuong, Zuzana Bednarikova, Andrea Antosova, Pham Dinh Quoc Huy, Katarina Siposova, Nguyen Anh Tuan, Mai Suan Li and Zuzana Gazova
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00004A, Concise Article
The structure of glyco-acridines determines their impact on insulin amyloid aggregation and newly introduced geometrical descriptors allow us to distinguish different binding affinities.
 
Bing Xu, Yan Gong, Xin Xu, Chenze Zhang, Yuzhong Zhang, Fuhao Chu, Hongbing Liu, Penglong Wang and Haimin Lei
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00552J, Concise Article
The novel ligustrazine derivatives were synthesized and displayed the remarkable protective effect (highest EC50 = 0.719 μM) on PC12 cells damaged by CoCl2.
 
A. Mohsen M. E. Omar, Omaima M. Aboulwafa, Doaa A. E. Issa, May M. S. El-Shokrofy, May E. Amr and Ibrahim M. El-Ashmawy
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00557K, Concise Article
Hypothesis for designing 6-substituted benzothiazolecarbamate prototype anthelmintics having diversities in flexibility and rigidity of substituents with different polar nature and hydrophilic–lipophilic properties.
 
Nikhil R. Madadi, Hongliang Zong, Amit Ketkar, Chen Zheng, Narsimha R. Penthala, Venumadhav Janganati, Shobanbabu Bommagani, Robert L. Eoff, Monica L. Guzman and Peter A. Crooks
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00478G, Concise Article
Novel resveratrol analogues have been synthesized and evaluated for their anticancer activities against a panel of 60 human cancer cell lines.
 
Dilip K. Tosh, Silvia Paoletta, Zhoumou Chen, Steven Crane, John Lloyd, Zhan-Guo Gao, Elizabeth T. Gizewski, John A. Auchampach, Daniela Salvemini and Kenneth A. Jacobson
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00571F, Concise Article
C2-phenylethynyl (dark green) and C2-phenyl-triazolyl (light green) nucleosides in the A3AR.
 
Daniela Rossi, Virpi Talman, Gustav Boije Af Gennäs, Annamaria Marra, Pietro Picconi, Rita Nasti, Massimo Serra, Jihyae Ann, Marialaura Amadio, Alessia Pascale, Raimo K. Tuominen, Jari Yli-Kauhaluoma, Jeewoo Lee and Simona Collina
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00564C, Concise Article
Over the past fifteen years, we reported the design and synthesis of different series of compounds targeting the C1 domain of protein kinase C (PKC) that were based on various templates.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00471J, Concise Article
From themed collection New Talent: Asia-Pacific
Computational chemistry plays an important supporting role in the early stages of drug discovery research.
 
Kavita Yadav, Priyanshu Bhargava, Sandhya Bansal, Manish Singh, Siddhi Gupta, Geeta Sandhu, Sandeep Kumar, Vedagopuram Sreekanth and Avinash Bajaj
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00289J, Concise Article
Anticancer drug Tamoxifen is modified to charged lithocholic acid derived amphiphile for enhanced cytotoxicity against breast cancer cells.
 
R. Elancheran, V. L. Maruthanila, M. Ramanathan, S. Kabilan, R. Devi, A. Kunnumakara and Jibon Kotoky
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00416G, Review Article
The main focus of this review is to discuss the discoveries and developments of various therapies for prostate cancer.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00481G, Concise Article
We have developed for the first time an excellent targeted metallic single component nanoparticle system for combination of PDT and chemotherapy.
 
Xin Zhao, Zhen-Wei Zhang, Wei Cui, Shengwei Chen, Yang Zhou, Jianghong Dong, Yanling Jie, Junting Wan, Yong Xu and Wenhui Hu
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00515E, Concise Article
Amantadine derivatives have been the only drugs marketed as M2 inhibitors of influenza A for decades.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD90005K, Correction
 
Paraskevi Karamtzioti, Asterios Papastergiou, John G. Stefanakis, Alexandros E. Koumbis, Ioanna Anastasiou, Maria Koffa and Konstantina C. Fylaktakidou
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00548A, Concise Article
Pyridine oxime esters are effective DNA photocleavers, causing single-/double-stranded DNA cleavage at concentrations as low as 1 μM.
 
Dag Erlend Olberg, Sven H. Hausner, Nadine Bauer, Jo Klaveness, Bård Indrevoll, Kjetil Wessel Andressen, Marie Dahl, Finn Olav Levy, Julie L. Sutcliffe and Ira Haraldsen
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00486H, Concise Article
A series of high affinity 18F-GnRH peptides have been synthesized and show utility as imaging agents for GnRH receptor expression in vivo.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00499J, Concise Article
A series of novel 4′-[(benzimidazol-1-yl)methyl]biphenyl-2-sulphonamides was designed, and their molecular model simulation fitting to a new HipHop 3D pharmacophore model was examined.
 
Debanjana Chakraborty, Arindam Maity, Chetan K. Jain, Abhijit Hazra, Yogesh P. Bharitkar, Tarun Jha, Hemanta K. Majumder, Susanta Roychoudhury and Nirup B. Mondal
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00469H, Concise Article
Dispiro andrographolides induce a caspase-dependent apoptotic cell death pathway in breast cancer (MCF-7) cells.
 
L. A. R. Carvalho, E. F. P. Ruivo, S. D. Lucas and R. Moreira
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00417E, Review Article
Activity-based protein profiling has emerged as an exceptional tool for biomarker discovery and validation.
 
Ratnesh Jain, Prajakta Dandekar, Brigitta Loretz, Marcus Koch and Claus-Michael Lehr
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00490F, Concise Article
DMC nanoparticles target Bfl1/A1 gene in lung macrophages and effective silencing of Bfl1/A1 gene by DMC nanoparticles paves the way for research on alternative treatment strategies for tuberculosis.
 

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