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Journal cover: MedChemComm


Research and review articles in medicinal chemistry and related drug discovery science; the official journal of the European Federation for Medicinal Chemistry
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Yun-Liang Zhang, Qi-Pin Qin, Qian-Qian Cao, Hong-Hua Han, Zhu-Ling Liu, Yan-Cheng Liu, Hong Liang and Zhen-Feng Chen
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00462H, Research Article
A rhodium(III) complex, [Rh(MQ)(DMSO)2Cl2] (1), with 8-hydroxy-2-methylquinoline as the ligand was synthesized and characterized. Complex 1 exhibited cytotoxicity against the BEL-7404, Hep-G2, NCI-H460, T-24, and A549 cell lines with IC50...
Aleksandra Ellert-Miklaszewska, Sabrina Dallavalle, Loana Musso, Nadine Martinet, Kamil Wojnicki and Bozena Kaminska
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00477F, Research Article
Compounds containing an isothiazolonaphthoquinone core and HDAC inhibitors with an indolyl-substituted biphenyl-4-yl-acrylohydroxamic acid are promising drug candidates against malignant brain tumors, glioblastomas.
Zhiqiang Wu, Xiaofei Tian, Songgui He, Lei Quan, Yunlu Wei and Zhenqiang Wu
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00491A, Research Article
Consumption of alcoholic beverages increases the risk of human health problems such as liver, heart and blood vessel diseases. This study provided insights and new data for the evaluation of the risks of alcohol consumption on proper behaviour and organ function and increased the awareness of the health risks associated with moderate and heavy drinking.
C. H. Castaneda, M. J. Scuderi, T. G. Edwards, G. D. Harris Jr., C. M. Dupureur, K. J. Koeller, C. Fisher and J. K. Bashkin
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00371K, Research Article
We report the synthesis of two novel pyrrole–imidazole polyamides with N-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing HPV strains.
Bibiana Ferreira, Maria Lie, Agnete Engelsen, Susana Machado, Wolfgang Link and James Lorens
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00394J, Review Article
Intrinsic and acquired resistance to conventional and targeted therapeutics is a fundamental reason for treatment failure in many cancer patients. Targeted approaches to overcome chemoresistance as well as resistance to...
Rupinder Kaur Gill, Ramandeep Kaur, Virender Kumar, Vivek Gupta, Gagandeep Singh and Jitender Bariwal
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD90049F, Correction
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD90047J, In the Pipeline
Does simple gene-editing mean the end of traditional medicinal chemistry? Probably not.
Umberto M. Battisti, Cinzia Citti, Giulio Rastelli, Luca Pinzi, Giulia Puja, Federica Ravazzini, Giuseppe Ciccarella, Daniela Braghiroli and Giuseppe Cannazza
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00440G, Research Article
The stereodiscrimination process in the binding of the R isomer with the receptor pocket is ruled by van der Waals interactions and/or H-bonding with water molecules.
Christine A. Herdman, Tracy E. Strecker, Rajendra P. Tanpure, Zhi Chen, Alex Winters, Jeni Gerberich, Li Liu, Ernest Hamel, Ralph P. Mason, David J. Chaplin, Mary Lynn Trawick and Kevin G. Pinney
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00459H, Research Article
Synthesis of benzocyclooctene and indene analogues inspired by colchicine and combretastatin A-4.
C. Morgat, R. Varshney, D. Vimont, C. Savona-Baron, C. Riès, C. Chanseau, S. S. Bertrand, A. K. Mishra, E. Hindié, P. Fernandez and J. Schulz
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD90048H, Correction
Tamara R. Todorović, Jelena Vukasinovic, Gustavo Portalone , Sherif Suleiman, Nevenka Gligorijević, Snezana Bjelogrlic, Katarina Jovanovic, Siniša Radulović, Katarina Anđelković, Analisse Cassar, Nenad R Filipović and Pierre Schembri-Wismayer
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00501B, Research Article
Cobalt complexes with semi- and thiosemicarbazones of 8-quinolinecarboxaldehyde have been synthesized and characterized by X-ray diffraction analysis. These novel complexes, and previously synthesized cobalt complex with selenium based selenosemicarbazone ligand,...
Zheng Liu, Si Yang, Xiaoyong Jin, Gaoxiao Zhang, Baojian Guo, Haiyun Chen, Pei Yu, Yewei Sun, Zaijun Zhang and Yuqiang Wang
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00509H, Research Article
A series of memantine nitrate derivatives as dual functional compounds of neuroprotection and vasodilatory activity for neurodegenerative diseases was designed and synthesized. These compounds combined the memantine skeleton and the...
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00456C, Research Article
We report the synthesis of eighteen new potential cancer chemopreventive agents, structurally designed to combine (naphtho)chalcone and (bromo)pyridine skeletons.
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00432F, Review Article
In cancers, Hypoxia Inducible Factor 1 (HIF-1) is an over-expressed transcription factor, which regulates a large set of genes involved in tumour vascularization, metastases formation, and cancer stem cells (CSCs)...
Menglu Jia, Rui Zhao, Bing Xu, Wenqiang Yan, Fuhao Chu, Hong-Shun Gu, Tianxin Xie, Hongjun Xiang, Jian Ren, Dagang Chen, Penglong Wang and Haimin Lei
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00344C, Research Article
Previous studies have demonstrated that natural steroid compounds containing peroxide bridge exhibited potential anti-hepatitis B virus activity. To continue our research, a simple and regioselective methodology, using Eosin Y as...
Ákos Urai, Andras Varadi, Levente Szocs, Balázs Komjáti, Valerie Le Rouzic, Amanda Hunkele, Gavril W Pasternak, Susruta Majumdar and Sándor Hosztafi
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00450D, Research Article
It was previously reported that 6β-aminomorphinan derivatives show high affinity for opiate receptors. Novel 6β-heteroarylamidomorphinanes were designed based on the MOR selective antagonist NAP. The 6β-aminomorphinanes were prepared with stereoselective...
Mohd. Imran Ahmad, Dushyant Singh Raghuvanshi, Sarita Singh, Aijaz A. John, Ravi Prakash, Kripa Shankar Nainawat, Divya Singh, Shubhandra Tripathi, Ashok Sharma and Atul Gupta
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00469E, Research Article
27b enhanced osteoblast differentiation at 1 pM in mouse calvarial osteoblast cells without inherent toxicity.
Antonella Accardo, Luisa Del Zoppo, Giancarlo Morelli, Daniele F. Condorelli, Vincenza Barresi, Nicolò Musso, Giorgia Spampinato, Francesco Bellia, Giovanni Tabbì and Enrico Rizzarelli
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00461J, Research Article
Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized.
Yvonne Wenker, Michael Soeberdt, Constantin Daniliuc, Sonja Ständer, Dirk Schepmann and Bernhard Wünsch
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00441E, Research Article
Additional N- and O-atoms in the bicyclic scaffold increase polarity and allow fine tuning of pharmacodynamic and pharmacokinetic properties of novel κ agonists.
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00463F, Research Article
Tumor cell resistance to drug treatment severely limits the therapeutic success of treatment. Tumor cells, exposed to chemotherapeutic drugs, have developed intricate strategies to escape the cytotoxic effects and adapt...
Koneni V. Sashidhara, L. Ravithej Singh, Mohammad Shameem, Sarika Shakya, Anoop Kumar, Tulsankar Sachin Laxman, Shagun Krishna, Mohammad Imran Siddiqi, Rabi S. Bhatta and Dibyendu Banerjee
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00447D, Research Article
A series of rationally designed new class of hLig1 inhibitors with potent in vitro anti-cancer properties is presented.
Ruomeng Qiu, Wenli Shi, Ting Cai, Siyu Pei, Ting Tang, Yafei Huang, Huan Wang, Liming Shao, Ju Qiu and Yonghui Wang
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00427J, Research Article
A series of N-biaryl amides were designed, quickly prepared by microwave-assisted solid-phase organic synthesis and phenotypically evaluated via mouse Th17 cell differentiation assay.
Deniz Cansen Yildirim, Gilles Hanquet, Loïc Jeanmart, Steve Lanners, Peter Šramel, Andrej Boháč and Rengul Cetin-Atalay
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00392C, Research Article
Bioactivities of quinoides 1-5 and VEGFR2 TKIs 6-10 were studied on hepatocellular cancer (HCC) and cancer stem cells (HCSCs). The compounds exhibited IC50 values in µM concentrations in HCC cells....
Ana Podolski-Renić, Zorica Milošević, Jelena Dinić, Tijana Stanković, Jasna Banković and Milica Pešić
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00391E, Review Article
Targeting stemness mechanisms leads to the suppression of ABC transporter activity and elimination of CSCs.
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00519E, Research Article
Human parainfluenza virus type-3 is a leading cause of acute respiratory infection in infants and children. There is currently neither vaccine nor clinically effective treatment of parainfluenza virus infection. Hemagglutinin-Neuraminidase...

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15 citations
A new series of exceptionally potent quinoline derivatives 6–30 as α-glucosidase inhibitors was identified.
DOI: 10.1039/C5MD00280J
Published: 21 Aug 2015
10 citations
The newest information (2010-present) on the four main mechanisms of resistance to the broad-spectrum aminoglycoside antibiotics is presented in details.
DOI: 10.1039/C5MD00344J
Published: 21 Sep 2015
28 citations
A systematic study on cell penetration by stapled peptides.
DOI: 10.1039/C4MD00131A
Published: 14 Oct 2014

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