Journal cover: MedChemComm


Broadening the field of opportunity for medicinal chemists. Official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.722 12 Issues per Year
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Vinayak Agarwal, Gaston Vondenhoff, Bharat Gadakh, Konstantin Severinov, Arthur van Aerschot and Satish Nair
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00204K, Concise Article
Peptide-nucleotide conjugates have been extensively studied as scaffolds for the development of new antibiotics. However, in vivo, the efficacy of such compounds is limited by various detoxicants, such as the...
Apirat Chaikuad, Andrew M. Petros, Oleg Fedorov, Jing Xu and Stefan Knapp
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00237G, Concise Article
Fragments for the development of ATAD2 bromodomain inhibitors have been identified and characterized by NMR and co-crystallization.
Wei Liu, Jianjun Tan, Mohammadreza Mohammadzad Mehryar, Zhiping Teng and Yi Zeng
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00214H, Review Article
HIV fusion inhibitors are a group of virus entry preventing drugs aiming at membrane fusion. Several peptide drugs are screened with potent capacity that blocks virus-host cell fusion efficiently, and...
Juntao Zhao, Nuannuan Sun, Yue Gao, Diya Lv, Yang Liu, Yan Jiang, Guoqiang Dong, Qianqian Chen, Wei Li, Youjun Zhou, Ju Zhu, Jiaguo Lv and Chunquan Sheng
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00160E, Concise Article
Human acrosin is a promising target for male contraceptives. A series of novel guanidinophenylpyrazole derivatives were rationally designed by molecular hybridization of the phenylpyrazole and guanidinobenzoate inhibitors. Most of the...
Wei Wang, Yoshinori Hirano, Takanori Uzawa, Mingzhe Liu, Makoto Taiji and Yoshihiro Ito
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00142G, Concise Article
To increase the inhibitory activity of purvalanol against cyclin-dependent kinase 2, we increased the extent of interaction between the inhibitor and the target by coupling a peptide aptamer to purvalanol.
Sanjay V. Malhotra, Vineet Kumar, Christian Velez and Beatriz Zayas
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00161C, Concise Article
A study of the effects of imidazolium-based ionic liquids on 60 human cancer cell lines representing diverse histologies has identified four compounds which show potency at a nanomolar dose.
Luca Unione, Silvia Galante, Dolores Díaz, F. Javier Cañada and Jesús Jiménez-Barbero
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00138A, Review Article
NMR allows the monitoring of molecular recognition processes in solution. Nowadays, a plethora of NMR methods are available to deduce the key features of the interaction from both the ligand or the receptor points of view.
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00159A, Concise Article
The present study reports the 3D QSAR of dopamine D2/D3 ligands to gain insights into the structural factors responsible for affinity and D3 selectivity.
Prashant Joshi, Samsher Singh, Abubakar Wani, Sadhana Sharma, Shreyans K Jain, Baljinder Singh, Bishan Gupta, Naresh Satti, S Koul, Inshad A Khan, Ajay Kumar, Sandip Bibishan Bharate and Ram A Vishwakarma
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00196F, Concise Article
The in-house IIIM natural product repository of 302 small molecules was screened for their ability to inhibit p-glycoprotein (Pgp) in Pgp-overexpressing human adenocarcinoma LS-180 cells. The screening has identified 13...
Rie Wakabayashi, Ryutaro Ishiyama, Noriho Kamiya and Masahiro Goto
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00179F, Concise Article
From themed collection In celebration of Seiji Shinkai's 70th Birthday
In the present study, we developed a novel surface-coated nanocarrier (SCN) for efficient and stable encapsulation of a poorly water-soluble anticancer agent, Camptothecin (CPT). Using emulsification and freeze-drying processes in...
Shane Devine, San Lim, Indu Chandrashekaran, Christopher MacRaild, Damien Drew, Cael Debono, Raymond Lam, Robin Anders, James Beeson, Martin Scanlon, Peter J. Scammells and Ray Norton
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00090K, Concise Article
We have determined that a previously reported class of pyrrolo[2,3-d]pyrimidine-4-amines exhibit low-binding to apical membrane antigen 1 (AMA1) and suffer from unattractive qualities, such as aggregation. We attempted to remove...
Fengxiang Du, Xiaoyi Zhang, Shan Li, Yaonan Wang, Meiqing Zheng, Yuji Wang, Shurui Zhao, Jianhui Wu, Lin Gui, Ming Zhao and Shiqi Peng
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00158C, Concise Article
The mechanism whereby CIPPCT forms nanoparticles capable of delivery in circulation and adhering on cancer cells is presented.
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00265B, Review Article
In recent years, gold-based compounds have been proved to hold promise in chemical biology being able to selectively inhibit proteins activities in cells and, therefore, to be exploited as either...
Rongjun He, Yunpeng Bai, Zhi-Hong Yu, Li Wu, Andrea M. Gunawan and Zhong-Yin Zhang
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00099D, Concise Article
Mycobacterium protein tyrosine phosphatase B (mPTPB) is a potential drug target of Tuberculosis (TB). Small molecule inhibitors of mPTPB could be a treatment to overcome emerging TB drug resistance. Using...
Maria Serratrice, Benoit Bertrand, Esmée F. J. Janssen, Eline Hemelt, Antonio Zucca, Fabio Cocco, Maria A. Cinellu and Angela Casini
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00241E, Concise Article
A number of gold(I) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer...
Saulo Andrade, Claudia Teixeira, Jonas Ramos, Marcela Lopes, Rodrigo Padua, Monica Oliveira, Elaine Souza-Fagundes and Ricardo Alves
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00136B, Concise Article
We have previously reported on a study of structure-activity relationship in a series of 2,3,4-substituted oxazolidines recently discovered by our group varying the substituent at ring or stereochemistry of the...
Wen-Chieh Wang, Hui-Yi Shiao, Chieh-Chien Lee, Ka-Shu Fung and Hsing-Pang Hsieh
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00048J, Review Article
This review elucidates the hit-to-drug evolution design of three ALK inhibitors.
Derong Ding, Katerina Lichtenwalter, Hualiang Pi, Shahriar Mobashery and Mayland Chang
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00172A, Concise Article
MMP-8 has been implicated in various diseases using a reported selective MMP-8 inhibitor that is actually a broad-spectrum MMP inhibitor.
Aamer Saeed, Yildiz Tehseen, Hummera Rafique, Norbert Furtmann, Jürgen Bajorath, Ulrich Flörke and Jamshed Iqbal
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00206G, Concise Article
Two new series of oxothiazolidine benzoate and acetate derivatives were synthesized and evaluated as aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitors.
Glenn L. Abbott, Xing Wu, Zhufeng Zhao, Lei Guo, Vladimir B. Birman, Brian B. Hasinoff and Gary I. Dmitrienko
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00197D, Concise Article
The diazo functionality of the kinamycins may not be an absolute requirement for bioactivity.
Yadagiri Kommagalla, Sinziana Cornea, Robert Riehle, Vladimir Torchilin, Alexei Degterev and Chepuri V. Ramana
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00109E, Concise Article
Replacement of a central thiourea unit of PITENINs (inhibitors of the phosphatidylinositol-3 kinase (PI3K) signaling pathway) with 1,2,3-triazole, lead to increased liver microsomal stability, drug likeness and toxicity towards cancer cells.
Phillip P. Sharp, Jean-Marc Garnier, David C. S. Huang and Christopher J. Burns
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00182F, Concise Article
This work provides new insights into a range of acetyl-lysine mimetics as BET bromodomain inhibitors.
Hiren Patel, Irina Chuckowree, Peter Coxhead, Matthew Guille, Minghua Wang, Alexandra Zuckermann, Robin S. B. Williams, Mariangela Librizzi, Ronald M. Paranal, James E. Bradner and John Spencer
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00211C, Concise Article
A HDAC, kinase inhibitor hybrid, (Z)-N1-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)-N8-hydroxyoctanediamide, 6, showed impressive anticancer action in a number of biochemical and cell-based assays.
Michele R. Richards, Michael G. Brant, Martin J. Boulanger, Christopher W. Cairo and Jeremy E. Wulff
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00168K, Concise Article
An analysis of the conformational distribution of peramivir, a potent anti-influenza compound, in solution and the solid state reveals a large conformational change required for enzyme binding.
Mathew C. Finniss, Kevin S. Chu, Charles J. Bowerman, J. Christopher Luft, Zishan A. Haroon and Joseph M. DeSimone
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00150H, Concise Article
Silyl ether chemistry was used as the linker for an antibody drug conjugate to release a chemotherapeutic at low pH.

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