Publishing: Journals, books and databases
Close Icon
 
Scheduled maintenance upgrade on Saturday 2nd of July 2016 from 11.30am to 3.00pm (BST)
During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.
Journal cover: MedChemComm

MedChemComm

Research and review articles in medicinal chemistry and related drug discovery science; the official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.319 12 Issues per Year
 
  • Advance Articles
  • |
  • Accepted Manuscripts
  • |
  • All Recent Articles
Prev Pg 1 of 2 Next
Ann M. Decker, John S. Partilla, Michael H. Baumann, Richard B. Rothman and Bruce E. Blough
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00245E, Research Article
From themed collection Membrane Transporters: Solute Carriers; Guest Edited by Prof Matthias A. Hediger & Dr David Hepworth
Vinylogous amphetamine analog S-6 is a potent dual dopamine/serotonin (DA/5-HT) releaser with no activity at 5-HT2 receptors.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00242K, Research Article
Discriminating between non-covalent and covalent inhibitors with SDS wash in microarray-based screen.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00269B, Research Article
The kinetic aspects of the ligand–receptor interaction, characterising the residence time of a ligand in its binding site, play an important role in drug effectiveness.
 
Junkai Huang, Zhuo Zhang, Peng Huang, Liqin He and Yong Ling
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00252H, Research Article
A series of rhein derivatives (4a-x) were synthesized and evaluated for their aqueous solubility and their in vitro anti-proliferative activities on six different tumor cell lines. The aqueous solubility of...
 
Zhilin Wu, Yilin Fang, Yuting Tang, Mengwu Xiao, Jiao Ye, Guoxi Li and Aixi Hu
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00234J, Research Article
A series of novel N-aryl-5-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(tert-butyl)thiazol-2-amines (C1-C31) were synthesized and evaluated for their antitumor activities against HeLa, A549 and MCF-7 cell lines. Some tested compounds showed potent growth inhibition properties with...
 
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00235H, Research Article
From themed collection Membrane Transporters: Solute Carriers; Guest Edited by Prof Matthias A. Hediger & Dr David Hepworth
Members of the organic anion transporting polypeptide (OATP) transporter family are involved in drug absorption and disposition, and therefore drug-drug and drug-food interactions at these transporters may have both pharmacological...
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00208K, Research Article
Substitution of multiple amide bonds by metabolically stable 1,2,3-triazoles yields novel tumour-targeting neurotensin-based peptidomimetics with interesting biological properties.
 
L. K. Petersen, P. Blakskjær, A. Chaikuad, A. B. Christensen, J. Dietvorst, J. Holmkvist, S. Knapp, M. Kořínek, L. K. Larsen, A. E. Pedersen, S. Röhm, F. A. Sløk and N. J. V. Hansen
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00241B, Research Article
A DNA-encoded small-molecule library was prepared using yoctoReactor technology followed by binder trap enrichment to identify selective inhibitors with nanomolar potencies against p38α MAP kinase.
 
Shahanavaj Khan, Anees A. Ansari, Abdul Arif Khan, Maha Abdulla, Omar Al- Obeed and Rehan Ahmad
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00219F, Research Article
This paper presents the results from a systematic study into the characterization and anticancer and biological activity of synthesized super-paramagnetic manganese oxide nanoparticles (Mn3O4-NPs).
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD90032A, Retraction
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD90031C, Correction
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00228E, Research Article
Sulfonyl isatin derivatives as multifunctional agents showing monoamine oxidase and caspase-3 inhibitory activities in the low micromolar range.
 
Jugal V. Mehta, Sanjay B. Gajera, Dilip B. Raval, Vasudev R. Thakkar and Mohan N. Patel
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00251J, Research Article
Spectral changes accompanying addition of HS DNA to solution of quinoline nucleus based piano stool coordination compounds indicate intercalative mode of binding of the compound between DNA base pairs.
 
Kang Chang, Yanxia Shi, Jianqin Chen, Zenghui He, Zheng Xu, Zhenjiang Zhao, Weiping Zhu, Honglin Li, yufang xu, Baoju Li and Xu Hong Qian
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00261G, Research Article
Plant immune system includes salicylic acid (SA) mediated systemic acquired resistance (SAR), and jasmonic acid (JA) mediated induced systemic resistance (ISR). To activate it, a large number of chemical inducers...
 
Ruo-Jun Man, Dan-Jie Tang, Xiao-Yuan Lu, Yong-Tao Duan, Xiang-xiang Tao, MengRu Yang, Le-le Wang, Bao-Zhong Wang, Chen Xu and Hai-Liang Zhu
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00255B, Research Article
Microtubule-targeted drugs play a critical role in various types of cancer therapy worldwide. In our study, a series of novel indole derivatives containing sulfonamide scaffold were designed, synthesized and biologically...
 
Dariusz Deredas, Krzysztof Huben, Anna Janecka, Angelika Długosz, Dorota Katarzyna Pomorska, Marek Mirowski, Urszula Krajewska, Tomasz Janecki and Henryk Krawczyk
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00118A, Research Article
A simple and general strategy for the synthesis of 3-methylene-4-(2-oxoalkyl)-3,4-dihydrocoumarins has been developed. The elaborated synthetic protocol includes 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) or Cs2CO3 promoted conjugate addition of enolizable ketones to 3-(diethoxyphosphoryl)coumarins...
 
María Belén Camarada, Cesar Echeverria and Rodrigo Ramirez-Tagle
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00200E, Review Article
Chagas disease (CD) is one of the most important neglected tropical disorders, being a major health concern in Latin America.
 
Patrycja Nowak-Sliwinska, Andrea Weiss, Emilia Păunescu, Catherine M. Clavel, Arjan W. Griffioen and Paul J. Dyson
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00271D, Research Article
Chlorambucil (CLB) derivatives with long fluorous (referred to as 1 and 2) or hydrocarbon (3) chains have been evaluated in a series of in vitro and in vivo assays.
 
Wenlin Song, Shiliang Li, Yi Tong, Jiawei Wang, Lina Quan, Zhuo Chen, Zhenjiang Zhao, Yufang Xu, Lili Zhu, Xuhong Qian and Honglin Li
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00179C, Research Article
A series of hydrazino-thiazole derivatives were synthesized, of which compound 22 was the most potent inhibitor of hDHODH (IC50 = 1.8 nM). Furthermore, 22 exhibited better antiproliferative activity than brequinar in cancer cell lines.
 
R. Ian Storer, Robert M. Owen, Andy Pike, Caroline L. Benn, Emma Armstrong, David C. Blakemore, Magda Bictash, Kathryn Costelloe, Emma Impey, Philip H. Milliken, Elisabeth Mortimer-Cassen, Hannah J. Pearce, Benjamin Pibworth and Gianna Toschi
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00190D, Research Article
From themed collection 2016 MedChemComm Hot Articles
A series of acidic heterocyclic sulfonamides that are potent and selective URAT1 inhibitors is described.
 
Nenad R. Filipović, Snežana Bjelogrlić, Gustavo Portalone, Sveva Pelliccia, Romano Silvestri, Olivera Klisurić, Milan Senćanski, Dalibor Stanković, Tamara R. Todorović and Christian D. Muller
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00199H, Research Article
The ligand initiated reprogramming of cancer stem cells phenotype in AsPC-1 cells. The complex digested plasmid DNA which might be the cause of its cytotoxic activity.
 
Dong-Jun Fu, Sai-Yang Zhang, Ying-Chao Liu, Xiao-Xin Yue, Jun-Ju Liu, Jian Song, Ruo-Han Zhao, Feng Li, Hui-Hui Sun, Yanbing Zhang and Hong-Min Liu
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00169F, Research Article
A series of novel 1,2,3-triazole-chalcone hybrids were designed, synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (SK-N-SH, HepG-2 and MGC-803). Most of the synthesized compounds...
 
Yu Li, Guiquan Xia, Qi Guo, Li Wu, Shizhen Chen, Zhigang Yang, wei wang, Zhonh-Yin Zhang, Xin Zhou and Zhong-Xing Jiang
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00277C, Research Article
Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatases (PTPs)-targeted drug discovery and imaging-guided PTP research with fluorine, several highly potent...
 
Carl S. Rye, Nicola E. A. Chessum, Scott Lamont, Kurt G. Pike, Paul Faulder, Julie Demeritt, Paul Kemmitt, Julie Tucker, Lorenzo Zani, Matthew D. Cheeseman, Rosie Isaac, Louise Goodwin, Joanna Boros, Florence Raynaud, Angela Hayes, Alan T. Henley, Emmanuel de Billy, Christopher J. Lynch, Swee Y. Sharp, Robert te Poele, Lisa O’ Fee, Kevin M. Foote, Stephen Green, Paul Workman and Keith Jones
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00159A, Research Article
A series of 4,6-disubstituted pyrimidines from a phenotypic screen targeting the HSF1 pathway are also potent inhibitors of CDK9.
 
Jessica E. Wynn, Wenyu Zhang, Denis M. Tebit, Laurie R. Gray, Marie-Louise Hammarskjold, David Rekosh and Webster L. Santos
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00171H, Research Article
Screening of a boronic acid and acridine containing branched peptide library revealed compounds that bind HIV-1 RRE RNA and inhibit HIV-1 replication.
 

Search this journal

Find an issue

MedChemComm (2010-Present)
Year *
Issue

Find an article

Journal*
Year*
Page 

Citation velocity

Articles from this journal that are regularly and recently being cited by others. We are trialling this feature to see if it makes it quicker and easier for you to find articles for your research. Read more about how we have created this filtering system.

5 citations
DOI: 10.1039/C5MD00344J
Published: 21 Sep 2015
12 citations
DOI: 10.1039/C5MD00152H
Published: 15 Jun 2015

Related news