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MedChemComm

Broadening the field of opportunity for medicinal chemists. Official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.626 12 Issues per Year
 
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Barbara Cortese, Stefania D'Amone, Giuseppe Gigli and Ilaria Elena Palamà
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00348A, Concise Article
IM–chitosan complex encapsulated poly(ε-caprolactone) (PCL) nanoparticles are proposed for their potential in enabling more intelligent controlled release and enhancing chemotherapeutic efficiency of IM.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00257A, Concise Article
Compound 9a showed dual anticancer and antimicrobial activity and compound 16 showed a broad spectrum antimicrobial activity.
 
Victoria Vinader, Maria Sadiq, Mark Sutherland, Mengying Huang, Paul M. Loadman, Lina Elsalem, Steven D. Shnyder, Hongjuan Cui, Kamyar Afarinkia, Mark Searcey, Laurence H. Patterson and Klaus Pors
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00411F, Concise Article
Selective cytochrome P450 bioactivation of truncated azinomycin.
 
Manish Singh, Sandhya Bansal, Somanath Kundu, Priyanshu Bhargava, Ashima Singh, Rajender K. Motiani, Radhey Shyam, Vedagopuram Sreekanth, Sagar Sengupta and Avinash Bajaj
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00223G, Concise Article
We report the enhanced anticancer activities of lithocholic acid amphiphiles possessing different charged head group for colon cancer therapy.
 
Yu'ning Song, Hao Xu, Wenmin Chen, Peng Zhan and Xinyong Liu
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00284A, Review Article
An overview of the broad-ranging pharmacological applications of 8-HQ derivatives.
 
Shuangling Chen, Yuji Wang, Shan Li, Yaonan Wang, Ming Zhao, Haimei Zhu, Jianhui Wu and Shiqi Peng
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00331D, Concise Article
High anti-thrombotic efficacy, action target and nano-structure of a novel nanomedicine were described.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00328D, Review Article
Low molecular weight compound competing for the binding of the p53 tumor suppressor to the MDM2 oncoprotein.
 
Isidro Cortés-Ciriano, Qurrat Ul Ain, Vigneshwari Subramanian, Eelke B. Lenselink, Oscar Méndez-Lucio, Adriaan P. IJzerman, Gerd Wohlfahrt, Peteris Prusis, Thérèse E. Malliavin, Gerard J. P. van Westen and Andreas Bender
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00216D, Review Article
Proteochemometric (PCM) modelling is a computational method to model the bioactivity of multiple ligands against multiple related protein targets simultaneously.
 
Haixiu Bai, Peng Zhu, Wenxiao Wu, Jing Li, Zhao Ma, Wei Zhang, Yanna Cheng, Lupei Du and Minyong Li
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00368C, Concise Article
A series of novel aryl triazoles was synthesized as firefly luciferase inhibitors in vitro and in vivo. More interestingly, these compounds are mixed noncompetitive for luciferin and noncompetitive for ATP.
 
Alexandra Manos-Turvey, Emma E. Watson, Melissa L. Sykes, Amy J. Jones, Jonathan B. Baell, Marcel Kaiser, Vicky M. Avery and Richard J. Payne
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00406J, Concise Article
The synthesis of a compound library based on a high throughput screening hit led to the discovery of several potent anti-trypanosomal agents.
 
Galina Karabanovich, Jaroslav Roh, Ondřej Soukup, Ivona Pávková, Markéta Pasdiorová, Vojtěch Tambor, Jiřina Stolaříková, Marcela Vejsová, Kateřina Vávrová, Věra Klimešová and Alexandr Hrabálek
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00301B, Concise Article
Tetrazole derivatives containing nitro substituents have been identified as promising antitubercular agents.
 
Inés González-Gil, Debora Zian, Henar Vázquez-Villa, Silvia Ortega-Gutiérrez and María L. López-Rodríguez
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00333K, Review Article
The current status of the LPA1 receptor and its ligands in the drug development pipeline is reviewed.
 
Francesca Bianchini, Chiara Calugi, Jessica Ruzzolini, Gloria Menchi, Lido Calorini, Antonio Guarna and Andrea Trabocchi
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00287C, Concise Article
A D-proline peptidomimetic targeting MMP-2 and MMP-9, being involved during tumor cell invasion and angiogenesis, was identified from a pool of compounds following enzyme inhibition kinetics and zymography, clearly highlighting...
 
Urara Hasegawa and André J van der Vlies
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00373J, Concise Article
Polymeric micelles for therapeutic delivery of hydrogen sulfide (H2S) were developed. The micelles released H2S in murine macrophages and enhanced proinflammatory responses induced by a Toll-like receptor 7 ligand, gardiquimod....
 
Michael. S. Christodoulou, Adeline Thomas, Stéphane Poulain, Melita Vidakovic, Maija Lahtela-Kakkonen, Daumantas Matulis, Philippe Bertrand, Eva Bartova, Christophe Blanquart, Emmanuel Mikros, Nikolas Fokialakis, Daniele Passarella, Rachid Benhida and Nadine Martinet
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00268G, Review Article
From themed collection Epigenetics
Why is it relevant to propose epigenetic “Nutricures” to prevent diseases linked with ageing?
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00312H, Concise Article
Hierarchical structure-based virtual screening against the sphingosine kinase 1(SphK1) binding pocket was performed. 25 compounds were selected for biological evaluation. Compound 25 exhibited comparable SphK1 and SphK2 inhibitory activities and anti-proliferative effects on U937 cells to the positive control N,N-dimethylsphingosine (DMS) 1. Further molecule dynamic (MD) simulations revealed the binding mode between SphK1 and 25.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00363B, Review Article
Quorum quenching compounds blocked quorum sensing system of bacteria by several mechanisms (a, b, c and d).
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00264D, Concise Article
This research aims to synthesize lipophilic berberine derivatives and evaluate their antiglioma effects on C6 and U87 cells.
 
Chiara Nardon, Giulia Boscutti, Lisa Dalla Via, Paola Ringhieri, Vito Di Noto, Giancarlo Morelli, Antonella Accardo and Dolores Fregona
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00299G, Concise Article
A sparingly water-soluble gold(III) complex was encapsulated in micelles functionalized with the CCK8-targeting moiety for the selective delivery of an anticancer drug.
 
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00407H, Concise Article
A series of novel derivatives of gambogenic acid (GNA) were synthesized and evaluated for their in vitro antiproliferation activity against four kinds of tumor cell lines. The compounds 3c, 3f,...
 
Doaa Boshra Farag, Nahla Ahmed Farag, Ahmed Esmat, Sally A. Abuelezz, Eman Abdel-Salam Ibrahim and Dalal A. Abou El Ella
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00392F, Concise Article
Four novel series of 1-substituted-3-(2-methyl-4-oxo-4H-quinazolin-3-yl) urea and/or thiourea IIIa-c, 4-substituted-N-(2-methyl-4-oxo-4H-quinazolin-3-yl) benzene sulfonamide VIa-c and their NO-hybrid molecules as nitrate esters Va-c, VIIIa-c have been synthesized and evaluated for their anti-inflammatory...
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00266K, Concise Article
A series of tetrazole derivatives were synthesized and characterized by NMR, IR, MS and HRMS spectroscopy.
 
Daniela Rossi, Annamaria Marra, Marta Rui, Erik Laurini, Maurizio Fermeglia, Sabrina Pricl, Dirk Schepmann, Bernhard Wuensch, Marco Peviani, Daniela Curti and Simona Collina
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00349G, Concise Article
To investigate the role of chirality in the ligand–σ1 receptor interaction, a series of enantiomeric arylalkylaminoalcohols and arylpyrrolidinols was evaluated by means of both in silico and in vitro studies.
 
Deepak Kumar, Garima Khare, Beena, Saqib Kidwai, Anil K. Tyagi, Ramandeep Singh and Diwan S. Rawat
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00288A, Concise Article
A series of isoniazid–amidoether derivatives was synthesized and screened for their antimycobacterial activity in vitro and in vivo.
 
Guilherme A. M. Jardim, Tiago T. Guimarães, Maria do Carmo F. R. Pinto, Bruno C. Cavalcanti, Kaio M. de Farias, Claudia Pessoa, Claudia C. Gatto, Divya K. Nair, Irishi N. N. Namboothiri and Eufrânio N. da Silva Júnior
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00371C, Concise Article
Naphthoquinone-based chalcone hybrids were synthesized and evaluated for their cytotoxic activity against four cancer cell lines and PBMC. Some of the hybrids exhibited promising anticancer activity with IC50 values < 1 μM.
 

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