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Journal cover: MedChemComm

MedChemComm

Broadening the field of opportunity for medicinal chemists. Official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.495 12 Issues per Year
 
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Qi Shen, Changsheng Zhang, Hongbo Liu, Yuting Liu, Junyue Cao, Xiaolin Zhang, Yuan Liang, Meiping Zhao and Luhua Lai
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00549C, Research Article
Helical peptide TNFα inhibitors were designed by targeting their dimer structure.
 
JiaWei Wang, YanYan Diao, JunSheng Zhu, ShiLiang Li, Zhenjiang Zhao, Honglin Li and Lili Zhu
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00024J, Research Article
Human dihydroorotate dehydrogenase (hDHODH) is an enzyme that catalyzes the fourth step in de novo pyrimidine biosynthesis, and its inhibitors restrict the growth of rapidly proliferating cells. Therefore, hDHODH has...
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00552C, Research Article
Methods utilizing continuous flow photochemistry have been developed for the synthesis of phenanthridinones via an intramolecular photochemical cyclization reaction in yields up to 99%, as a means to generate poly(ADP-ribose) polymerase inhibitors.
 
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00011H, Research Article
Herein, we describe the discovery of a novel binding pocket for CYP 2C9 inhibitors. Trifluoromethanesulfonamide compounds 1 and 2, identified within a Pfizer progesterone receptor antagonist program, were found to...
 
Maria João Matos, Santiago Vilar, Sonja Kachler, Saleta Vazquez-Rodriguez, Carla Varela, GIOVANNA LUCIA DELOGU, George Hripcsak, Lourdes Santana, Eugenio Uriarte, Karl-Norbert Klotz and Fernanda Borges
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C5MD00573F, Research Article
Adenosine receptors (AR) are GPCRs involved in several biochemical processes. Agents able to selectively modulate the activity of theses receptors represent promising multifunctional agents to delay or slow the progression...
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00583C, Research Article
The human pharmacokinetic parameters of 215 marketed oral drugs have been collated and their estimated plasma concentrations (following repeat dosing) profiled against time using a one-compartment model.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00445D, Research Article
From themed collection New Talent: Europe
A novel PSD-95 PDZ2 peptidomimetic has been discovered by designing azide and alkyne amino acid analogues and click chemistry.
 
Deepak Singh Kapkoti, Vivek Kumar Gupta, Mahendra Padurang Darokar and Rajendra Singh Bhakuni
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00527B, Research Article
16 folds reduction in MICs with norfloxacin against various clinical isolates of MRSA (FICI range from 0.312–0.375).
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00562K, Research Article
The c-Jun N-terminal kinase (JNK) family, which comprises JNK1, JNK2 and JNK3, belongs to the mitogen-activated protein kinase (MAPK) superfamily, whose members regulate myriad biological processes, including those implicated in tumorigenesis and neurodegenerative disorders.
 
Stefan Kathman and Alexander V Statsyuk
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C5MD00518C, Review Article
Covalent probes and drugs have found widespread use as research tools and clinical agents. Covalent probes are useful because of their increased intracellular potency and because covalent labeling of cellular...
 
Zia ud Din, Alef dos Santos, Marilia Almeida Trapp, Danielle Lazarin-Bidóia, Francielle Garcia, Francieli Peron, Celso Vataru Nakamura and Edson Rodrigues Filho
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C5MD00599J, Research Article
Unsymmetrical diraylpentanoids analogues analogues of curcumin has been synthesized by the claisen schmidth condensation of different aldehydes and ketones. Anisaldehyde treated with 2-butanone and chlorobenzaldehyde with 2-pentanone resulted in intermediate...
 
Hong Chuang, Lin-Chiang Sherlock Huang, Mohit Kapoor, Yi-Jen Liao, Cheng-Lin Yang, Chia-Ching Chang, Chun-Yi Wu, Jih Ru Hwu, Tsurng-Juhn Huang and Ming-Hua Hsu
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00008H, Research Article
Hepatits B virus (HBV) is an infectious disease, which can cause acute and chronic infections. Every year, an over 7.5 million person dies due to HBV. No effective drug exists...
 
Ghamdan Beshr, Roman Sommer, Dirk Hauck, David Chan Bodin Siebert, Anna Hofmann, Anne Imberty and Alexander Titz
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00557D, Research Article
From themed collection New Talent: Europe
Burkholderia cenocepacia is an opportunistic Gram-negative pathogen and especially hazardous for cystic fibrosis patients.
 
Rui-Xue Rong, Qian Sun, Cui-Lan Ma, Bin Chen, Wen-Ying Wang, Zhong-Ao Wang, Ke-Rang Wang, Zhi-Ran Cao and Xiao-Liu Li
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00543D, Research Article
Novel bis-naphthalimide derivatives NI1–6 were synthesized, which exhibited selective cytotoxic activity, especially for NI1. Furthermore, NI1 as a DNA intercalator exhibited fluorescence enhancement upon binding with Ct-DNA, fluorescence imaging with Hela cells and different impacts on the cell cycle compared with amonafide.
 
Mariem Chayah, M. Encarnación Camacho, M. Dora Carrión, Miguel A. Gallo, Miguel Romero and Juan Duarte
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00477B, Research Article
N,N′-Disubstituted thioureas and ureas as nNOS and iNOS inhibitors were synthesized. Thiourea 4g was the best inhibitor without eNOS inhibition.
 
Mei-Yan Huang, Jing Lin, Zhi-Jian Huang, Hong-Gui Xu, Juan Hong, Ping-Hua Sun, Jia-Liang Guo and Wei-Min Chen
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00577A, Research Article
A series of novel 9-O-substituted-berberine derivatives were synthesized and their anti-inflammatory activities were evaluated. Among them, compounds 3i and 5e exhibited excellent anti-inflammatory potential.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00508F, Research Article
The new prosthetic group 18F-TEG-DBCO (dibenzocyclooctyne) can be prepared within a total reaction time of 60 min including purification with an overall yield (n.d.c.) of 34 ± 5%. Copper-free click cycloadditions with various biomolecule-azides resulted in very high RCYs under mild conditions.
 
Tobias Linder, Harald Bernsteiner, Priyanka Saxena, Florian Bauer, Thomas Erker, Eugen Timin, Steffen Hering and Anna Stary-Weinzinger
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00443H, Research Article
From themed collection New Talent: Europe
The hERG cavity can trap very bulky compounds, without perturbing normal gate closure.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00581G, Research Article
A series of novel bivalent β-carbolines were synthesized and evaluated for their anti-proliferative activities on a panel of cancer cell lines, apoptosis induction and cell cycle effects.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00534E, Research Article
We tailored 10H-acridin-9-one and (S)-tyrosine into 3-(4-hydroxyphenyl)-2-[(9-oxo-9,10-dihydroacridine-4-carbonyl) amino]propionic acid (2).
 
Atulya Nagarsenkar, Santosh Kumar Prajapti, Sravanthi Devi Guggilapu, Swetha Birineni, Sudha Sravanti Kotapalli, Ramesh Ummanni and Bathini Nagendra Babu
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00513B, Research Article
Novel triazole-linked indole and oxindole glycoconjugates as inhibitors of the Akt/PKB signaling pathway.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00566C, Research Article
Matching molecular series. Shown is a pair of structurally related matching molecular series that display different SAR characteristics.
 
Laurence Deyon-Jung, Christophe Morice, Florence Chéry, Julie Gay, Thierry Langer, Marie-Céline Frantz, Roger Rozot and Maria Dalko-Csiba
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00444F, Research Article
From themed collection New Talent: Europe
A fragmentation–recombination process coupled with fragment-based pharmacophore in silico screening: a tailor-made approach for the discovery of new cosmetics.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00481K, Review Article
Pan-assay interference compounds (PAINS) are molecules showing promising but deceptive activities in various biochemical screenings mainly due to unselective interactions with the target.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00499C, Research Article
From themed collection 2016 MedChemComm Hot Articles
Systematic plane scans reveal a seamless transition from σ-hole interactions with the carbonyl oxygen to interactions with the amide π-electrons at increasing distances.
 

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