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MedChemComm

Broadening the field of opportunity for medicinal chemists. Official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.722 12 Issues per Year
 
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Stephen Hanessian, Oscar M. Saavedra, Miguel A. Vilchis-Reyes and Ana M. Llaguno-Rueda
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00072B, Concise Article
The syntheses of 4′-deoxy-4′-fluoro neamine and 4′-deoxy-4′-fluoro 4′-epi neamine from the readily available neamine and paromamine are described.
 
Amit Mahindra, Krishna K. Sharma, Dinesh Rathore, Shabana. I. Khan, Melissa R. Jacob and Rahul Jain
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00041B, Concise Article
In this communication, we report the design, synthesis and in vitro antimicrobial activity of ultra short peptidomimetics.
 
Sophie Le Trionairre, Alexis Perry, Bartosz Szczesny, Szabo Csaba, Paul Winyard, Jacqueline Whatmore, Mark E. Wood and Matt Whiteman
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C3MD00323J, Concise Article
Synthesis and bioavailability of the endogenous gasomediator hydrogen sulfide (H2S) is perturbed in many disease states, including those involving mitochondrial dysfunction. There is intense interest in developing pharmacological agents to...
 
Weiwei Chen, Takahiko Matsushita, Dimitri Shcherbakov, Heithem Boukari, Andrea Vasella, Erik Bottger and D Crich
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00119B, Concise Article
A series of 4’-O-glycopyranosyl paromomycin analogs and a 4’-O-(glucosyloxymethyl) derivative were synthesized and evaluated for their ribosomal activity to determine the influence of the glycosyl moiety on drug activity and...
 
Christine Meck, Michael P. D'Erasmo, Danielle R. Hirsch and Ryan P. Murelli
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00055B, Review Article
α-Hydroxytropolones are promising leads for a diverse range of therapeutic applications. The following review will discuss the biological studies on α-hydroxytropolones and the synthetic methods available to access them.
 
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00094C, Concise Article
Dimerization is an essential step of the Hsp90 cycle. This work describes the results of a molecular dynamics and dimerization free energy analysis performed on the structure of the human...
 
Anne-Sophie Journé, Samy A.M. Habib, Bala R. Dodda, Mina N.F. Morcos, Mirna S. Sadek, Sarah A.A. Tadros, Paula Witt-Enderby, Ralf Jockers and Darius Paul Zlotos
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00079J, Concise Article
A novel series of dimeric melatonin analogues obtained by connecting two melatonin molecules through N1 with spacers of 15-24 atoms was synthesized and characterized in 2-[125-I]-iodomelatonin binding and bioluminescence resonance...
 
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00049H, Concise Article
Cortexolone-17α-propionate is a topical antiandrogen under investigation for the treatment of androgen related skin disorders. A full conformational characterization was realized, in comparison with others steroidal androgens and antiandrogens, by...
 
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00012A, Review Article
Infections caused by drug resistant and/or slow-growing bacteria are increasingly becoming some of the greatest challenges of health organizations worldwide.
 
Steffen van der Wal, Chantelle J. Capicciotti, Stamatia Rontogianni, Robert N. Ben and Rob M. J. Liskamp
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00013G, Concise Article
An azido/alkyne-containing glycopeptide monomer was synthesized and CuAAC-oligomerized to obtain a triazole-containing antifreeze glycopeptide analogue with moderate antifreeze activity.
 
Srikant Bhagat, Parth Shah, Sanjeev K. Garg, Shweta Mishra, Preet Kamal Kaur, Sushma Singh and Asit K. Chakraborti
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C3MD00388D, Concise Article
α-Aminophosphonates have been identified as novel anti-leishmanial chemotypes against the L. donovani promastigote with low μM range activity.
 
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00074A, Concise Article
The synthesis of 1-deoxynojirimycin (DNJ) derivatives, presenting a 2-naphthylmethyl and an alkyl amino side chain, from L-sorbose is described.
 
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C3MD00346A, Review Article
Bacterial adhesion is an important first step towards bacterial infection and plays a role in colonization, invasion and biofilm formation.
 
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00038B, Concise Article
Structural changes of PS A1 does not alter function.
 
Kazem Ahmed Mahmoud, Tom Wersig, Inna Slynko, Frank Totzke, Christoph Schächtele, Markus Oelze, Wolfgang Sippl, Christoph Ritter and Andreas Hilgeroth
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00028E, Concise Article
Novel 4-anilino pyrido[2,3-b]indoles have been discovered as inhibitors of the breast cancer relevant protein kinase Brk.
 
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00095A, Concise Article
Ten members of the mezzettiaside family of natural products were synthesized and evaluated for anticancer and antibacterial activity.
 
Lucas Cunha Duarte Coelho, Marcos Veríssimo de Oliveira Cardoso, Diogo Rodrigo Magalhães Moreira, Paulo André Teixeira de Moraes Gomes, Gevanio Bezerra de Oliveira Filho, Suellen Melo Tibúrcio Cavalcanti, Lucianna Rabelo Pessoa Siqueira, Miria de Oliveira Barbosa, Arsenio Rodrigues Oliveira, Elizabeth Fernanda de Oliveira Borba, Teresinha Gonçalves Silva, Belinda Kaskow, Mahdad Karimi, Lawrence J Abraham and Ana Cristina Lima Leite
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00070F, Concise Article
Modulation of the immune system is an emerging concept in the control of tumor growth. Bearing in mind the pharmacological property of Thalidomide and its phthalimide derivatives, we describe here...
 
Med. Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4MD00053F, Concise Article
Through the use of chemical synthesis and high throughput screening, we discovered a sulfonamide hydroxamic acid inhibitor for the botulinum neurotoxin serotype A light chain. A structure activity relationship study...
 
Gautam Patel, Norma E. Roncal, Patricia J. Lee, Susan E. Leed, Jessey Erath, Ana Rodriguez, Richard J. Sciotti and Michael P. Pollastri
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00045E, Concise Article
Hesperadin, an established human Aurora B inhibitor, was tested against cultures of Trypanosoma brucei, Leishmania major, and Plasmodium falciparum, and was identified to be a potent proliferation inhibitor.
 
Xian-Wei Ye, Yi-Chao Zheng, Ying-Chao Duan, Meng-Meng Wang, Bin Yu, Jing-Li Ren, Jin-Lian Ma, En Zhang and Hong-Min Liu
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00031E, Concise Article
Design of novel coumarin–1,2,3-triazole–dithiocarbamate hybrids as potent LSD1 inhibitors by introducing a coumarin scaffold.
 
V. Rempel, K. Atzler, A. Behrenswerth, T. Karcz, C. Schoeder, S. Hinz, M. Kaleta, D. Thimm, K. Kiec-Kononowicz and C. E. Müller
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C3MD00394A, Concise Article
GPR18 and GPR55 are orphan G protein-coupled receptors (GPCRs) that interact with certain cannabinoid (CB) receptor ligands.
 
Soledad Ravetti, Cristian A. De Candia, María S. Gualdesi, Sandra Pampuro, Gabriela Turk, Mario A. Quevedo and Margarita C. Briñón
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00003J, Concise Article
These prodrugs of DDI with increased lipophilicity and good antiviral performance should be of interest in HIV therapy.
 
Thipvaree Wangchareansak, Arunee Thitithanyanont, Daungmanee Chuakheaw, M. Paul Gleeson, Peter A. Lieberzeit and Chak Sangma
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C3MD00272A, Concise Article
We investigate whether a molecularly imprinted polymer (MIP) of influenza A H5N1 could be used to help identify molecules capable of binding to, and inhibiting the function of the virus, via either competitive or allosteric mechanisms.
 
Sanjeev Kumar V. Vernekar, Li Qiu, Jeana Zacharias, Robert J. Geraghty and Zhengqiang Wang
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4MD00039K, Concise Article
The Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) of 4′-azidothymidine (5) generated a series of 1,2,3-triazole analogues (9) with moderate anti-HIV activities, while a similar cycloaddition reaction catalyzed by Ru(II) failed.
 
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C3MD00376K, Concise Article
Resveratrol derivatives were designed and synthesized as multitarget-directed agents for treating AD, and 6r was a balanced inhibitor toward all the tested targets.
 

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