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MedChemComm

Broadening the field of opportunity for medicinal chemists. Official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.626 12 Issues per Year
 
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Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00481G, Concise Article
We have developed for the first time an excellent targeted metallic single component nanoparticle system for combination of PDT and chemotherapy.
 
A. Mohsen M.E. Omar, Omaima M. Aboulwafa, Doaa A. E. Issa, May M.S. El-Shokrofy, May E. Amr and Ibrahim M. El-Ashmawy
Med. Chem. Commun., 2015, Accepted Manuscript
DOI: 10.1039/C4MD00557K, Concise Article
Series of new substituted 6-methoxybenzothiazoles were synthesized and evaluated for their anthelmintic activity. The synthesis of the desired compounds was achieved through the key intermediate 2-(2-Aminobenzothiazol-6-yloxy)acetohydrazide 6. Target compounds were...
 
Xin Zhao, Zhen-Wei Zhang, Wei Cui, Shengwei Chen, Yang Zhou, Jianghong Dong, Yanling Jie, Junting Wan, Yong Xu and Wenhui Hu
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00515E, Concise Article
Amantadine derivatives have been the only drugs marketed as M2 inhibitors of influenza A for decades.
 
Daniela Rossi, Virpi Talman, Gustav Boije, Annamaria Marra, pietro Picconi, Rita Nasti, Massimo Serra, ANN JIHYAE, Marialaura Amadio, Alessia Pascale, Jeewoo Lee, Raimo Tuominen, Jari Yli-Kauhaluoma and Simona Collina
Med. Chem. Commun., 2015, Accepted Manuscript
DOI: 10.1039/C4MD00564C, Concise Article
Over the past fifteen years, we reported the design and synthesis of different series of compounds targeting the C1 domain of protein kinase C (PKC) that were based on various...
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD90005K, Correction
 
Paraskevi Karamtzioti, Asterios Papastergiou, John G. Stefanakis, Alexandros E. Koumbis, Ioanna Anastasiou, Maria Koffa and Konstantina C. Fylaktakidou
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00548A, Concise Article
Pyridine oxime esters are effective DNA photocleavers, causing single-/double-stranded DNA cleavage at concentrations as low as 1 μM.
 
Dag Erlend Olberg, Sven H. Hausner, Nadine Bauer, Jo Klaveness, Bård Indrevoll, Kjetil Wessel Andressen, Marie Dahl, Finn Olav Levy, Julie L. Sutcliffe and Ira Haraldsen
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00486H, Concise Article
A series of high affinity 18F-GnRH peptides have been synthesized and show utility as imaging agents for GnRH receptor expression in vivo.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00499J, Concise Article
A series of novel 4′-[(benzimidazol-1-yl)methyl]biphenyl-2-sulphonamides was designed, and their molecular model simulation fitting to a new HipHop 3D pharmacophore model was examined.
 
Debanjana Chakraborty, Arindam Maity, Chetan K. Jain, Abhijit Hazra, Yogesh P. Bharitkar, Tarun Jha, Hemanta K. Majumder, Susanta Roychoudhury and Nirup B. Mondal
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00469H, Concise Article
Dispiro andrographolides induce a caspase-dependent apoptotic cell death pathway in breast cancer (MCF-7) cells.
 
L. A. R. Carvalho, E. F. P. Ruivo, S. D. Lucas and R. Moreira
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00417E, Review Article
Activity-based protein profiling has emerged as an exceptional tool for biomarker discovery and validation.
 
Ratnesh Jain, Prajakta Dandekar, Brigitta Loretz, Marcus Koch and Claus-Michael Lehr
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00490F, Concise Article
DMC nanoparticles target Bfl1/A1 gene in lung macrophages and effective silencing of Bfl1/A1 gene by DMC nanoparticles paves the way for research on alternative treatment strategies for tuberculosis.
 
Ryosuke Misu, Koki Yamamoto, Ai Yamada, Taro Noguchi, Hiroaki Ohno, Takashi Yamamura, Hiroaki Okamura, Fuko Matsuda, Satoshi Ohkura, Shinya Oishi and Nobutaka Fujii
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00514G, Concise Article
From themed collection New Talent: Asia-Pacific
A potent neurokinin-3 receptor (NK3R) selective agonist with resistance to proteolytic digestion was developed.
 
Kavita Yadav, Priyanshu Bhargava, Sandhya Bansal, Manish Singh, Siddhi Gupta, Geeta Sandhu, Sandeep Kumar, Vedagopuram Sreekanth and Avinash Bajaj
Med. Chem. Commun., 2015, Accepted Manuscript
DOI: 10.1039/C4MD00289J, Concise Article
Modulation of existing drugs is required to achieve enhanced activity for cancer therapy by lowering their effective dose. Strategies of introduction of cationic charge and hydrophobicity have been proposed and...
 
Liuqing Yang, Wei Liu, Hanbing Mei, Yuan Zhang, Xiaojuan Yu, Yufang Xu, Honglin Li, Jin Huang and Zhenjiang Zhao
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00498A, Concise Article
The present study reports a series of novel potent farnesyltransferase inhibitors from chemical modifications of the lead compounds, such as compound 13n with an IC50 value of 0.0029 μM.
 
Silvia Franchini, Annamaria Baraldi, Claudia Sorbi, Federica Pellati, Elena Cichero, Umberto M. Battisti, Piero Angeli, Antonio Cilia and Livio Brasili
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00484A, Concise Article
Enantioseparation and stereoselective synthesis of (1), a potent 5-HT1AR ligand, were performed. Surprisingly, the enantiomers proved to be equipotent.
 
Veronica Rodriguez, Sergio Valente, Stefano Rovida, Dante Rotili, Giulia Stazi, Alessia Lucidi, Giuseppe Ciossani, Andrea Mattevi, Oronza A. Botrugno, Paola Dessanti, Ciro Mercurio, Paola Vianello, Saverio Minucci, Mario Varasi and Antonello Mai
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00507D, Concise Article
A new series of pyrrole/indole-containing tranylcypromine analogues is reported as potent and selective LSD1 inhibitors active in leukemia.
 
Xiaomeng He, Yan Jiang, Yongqiang Zhang, Shanchao Wu, Guoqiang Dong, Na Liu, Yang Liu, Jianzhong Yao, Zhenyuan Miao, Yan Wang, Wannian Zhang and Chunquan Sheng
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00505H, Concise Article
A series of novel triazole antifungal agents containing piperidine-oxadiazole side chains were designed and synthesized. Compound 11b was highly active against Candida albicans with a MIC value of 0.016 μg mL−1.
 
Mark A. Skidmore, Anna Kajaste-Rudnitski, Nicola M. Wells, Scott E. Guimond, Timothy R. Rudd, Edwin A. Yates and Elisa Vicenzi
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00516C, Concise Article
Chemically modified heparin derivatives offer a potential source of effective inhibitors of viral attachment, which are suitable for further optimisation.
 
Kristian M. Jacobsen, Ulrik B. Keiding, Lise L. Clement, Eva S. Schaffert, Neela D. S. Rambaruth, Mogens Johannsen, Kurt Drickamer and Thomas B. Poulsen
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00512K, Concise Article
We demonstrate that the natural product brartemicin, a newly discovered inhibitor of cancer cell invasion, is a high-affinity ligand of the carbohydrate-recognition domain (CRD) of the C-type lectin mincle.
 
Bich Anh Chau, Grant Drummond, W. Roy Jackson, Bevyn Jarrott, Alyson A. Miller, Kamani R. Subasinghe, Christina Y. R. Tan, Paul J. White, Christine E. Wright and James Ziogas
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00459K, Concise Article
Some mexiletine derivatives with isoindoline based antioxidants attached have been shown to have significant cardioprotective properties.
 
Yoshiaki Masaki, Takeshi Inde, Tetsuya Nagata, Jun Tanihata, Takashi Kanamori, Kohji Seio, Shin'ichi Takeda and Mitsuo Sekine
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00468J, Concise Article
Incorporation of 2′-O-methyl-2-thioribothymidine (s2Tm) into antisense oligoribonucleotides significantly enhanced the exon skipping activity in Duchenne muscular dystrophy model mice.
 
Ramakrishnan Elancheran, V.L Maruthanila, M Ramanathan, S Kabilan, R Devi, A Kunnumakara and Jibon Kotoky
Med. Chem. Commun., 2015, Accepted Manuscript
DOI: 10.1039/C4MD00416G, Review Article
The main focus of the review is to discuss the discoveries and developments of various therapies for prostate cancer. The AR has played an important role in Prostate cancer growth...
 
Na Liu, Fabao Zhao, Haiyong Jia, Diwakar Rai, Peng Zhan, Xuemei Jiang and Xinyong Liu
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00521J, Review Article
In this review, we focus on the recent advances in discovery, structural modifications and biological activities studies of several distinct classes of synthetic non-nucleoside small molecular compounds with new mechanisms.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00470A, Concise Article
New insights into physicochemical drivers for Caco-2 permeability have been gained using a modelling technique known as block relevance analysis.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00401A, Concise Article
Substituted 2-(oxazole-2-yl)phenols: a new class of HDAC inhibitors with a novel zinc binding group.
 

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