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MedChemComm

Broadening the field of opportunity for medicinal chemists. Official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.495 12 Issues per Year
 
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Vishal Sharma, Ashun Chaudhary, Gousia Chashoo, Saroj Arora, Ajit K. Saxena and Mohan Paul S. Ishar
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00289C, Concise Article
A series of cyclobutanones (7a–f) were synthesized by irradiation of β-ionone derived chalcones (4a–f) in aqueous methanol and further converted to polycyclic γ-lactones (8a–f) by Baeyer–Villiger oxidation.
 
Petr Pachl, Ondřej Šimák, Pavlína Řezáčová, Milan Fábry, Miloš Buděšínský, Ivan Rosenberg and Jiří Brynda
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00235D, Concise Article
Based on previously known inhibitor–enzyme complex structures, we developed a promising inhibitor by mimicking the phosphate ion and achieved 50- and 100-fold increases in the inhibitory potency towards cdN and mdN, respectively.
 
M. Petaccia, M. Condello, L. Giansanti, A. La Bella, F. Leonelli, S. Meschini, D. Gradella Villalva, E. Pellegrini, F. Ceccacci, L. Galantini and G. Mancini
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00077G, Concise Article
Liposomes containing novel 5-fluorouracil derivatives differing in the length of their polyoxyethylenic spacer were shown active against colorectal tumor cells.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00264H, Concise Article
A novel 3-hydroxypyridin-4-one hexadentate-based copolymeric iron chelator was prepared. The polymer was found to possess high iron affinity and appreciable inhibitory activity against both Gram-positive and Gram-negative bacteria.
 
Naveen Kuntala, Jhonsee Rani Telu, Venkanna Banothu, Suresh Babu Nallapati, Jaya Shree Anireddy and Sarbani Pal
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00224A, Concise Article
A remarkably rapid CuAAC strategy afforded benzoxepine-1,2,3-triazole hybrids as potential antibacterial/cytotoxic agents.
 
Stefania Villa, Arianna Gelain, Luca Rizzi, Laura Legnani, Aurora Pacini, Katerina Spyridaki, Vlasios Karageorgos and George Liapakis
Med. Chem. Commun., 2015, Accepted Manuscript
DOI: 10.1039/C5MD00259A, Concise Article
Novel GnRH I and II analogues were designed and synthesized by Solid Phase Peptides Synthesis (SPPS), since GnRH has antiproliferative property, but poor metabolic stability. To rationalize synthetic difficulties, molecular...
 
Guofang Li, yanbao zhao, Ping Li, Fuqiang Zhang, Peng Qu, Binjie Li, Qingyu Gao and Shaorong Wang
Med. Chem. Commun., 2015, Accepted Manuscript
DOI: 10.1039/C5MD00275C, Concise Article
Inorganic antibiotics, with low cost, low occurrence of antibacterial resistance, and long-term effect, have attracted great research interest and been widely used in many fields. However, few investigations have focused...
 
Mark E. Wood, Matt Whiteman, Benjamin Edwin Alexander, Bridget Fox, Tahmina Khan, Joseph Maliszewski, Alexis Perry, Simon Coles and Mateusz Pitak
Med. Chem. Commun., 2015, Accepted Manuscript
DOI: 10.1039/C5MD00170F, Concise Article
www.rsc.org/ Investigating the generation of hydrogen sulfide from the phosphinodithioate slow-release donor GYY4137 Benjamin E. Alexander,a Simon J. Coles,b Bridget C. Fox,c Tahmina F. Khan,a Joseph Maliszewski,a Alexis Perry,a Mateusz...
 
Andreia Aguiar Vieira, Bruno Guimarães Marinho, Luana Gonçalves de Souza, Patricia Dias Fernandes and José D. Figueroa-Villar
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00187K, Concise Article
This work describes the design, synthesis and in vivo evaluation of new central nervous system depressing agents that show low levels of acute toxicity, high solubility in water, anxiolytic and hypnotic effects without sleep deprivation.
 
Paul Bamborough and Chun-wa Chung
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00209E, Review Article
A review of fragment-based approaches to finding and optimising bromodomain inhibitors. Early successes against the BET subfamily are now being extended to other members of the target class.
 
Ainhoa Mascaraque, Wioleta Kowalczyk, Tahia Fernández, Francisca Palomares, Cristobalina Mayorga, David Andreu and Javier Rojo
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00133A, Concise Article
From themed collection 1st EFMC Young Medicinal Chemist Symposium
A GDP displaying the NP366–374 influenza A virus epitope induces an immunostimulatory effect, emerging as a potential flu vaccine.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00227C, Concise Article
Inspired by curcumin, which is a natural traditional Chinese medicine, a sulindac-based compound was designed and synthesized.
 
John Mann, Peter W. Taylor, Colin R. Dorgan, Peter D. Johnson, Francis X. Wilson, Richard Vickers, Aaron G Dale and Stephen Neidle
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00238A, Review Article
The story of the discovery of the bis-benzimidazole derivative SMT19969, which is currently in clinical trials against the pathogen Clostridium difficile.
 
Anna Bujak, Filip Stefaniak, Daria Zdzalik, Paulina Grygielewicz, Barbara Dymek, Marcin Zagozda, Pawel Gunerka, Monika Lamparska-Przybysz, Krzysztof Dubiel, Maciej Wieczorek and Karolina Dzwonek
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00090D, Concise Article
TRAF-2 and NCK-interacting kinase (TNIK) is a serine–threonine kinase with a proposed role in Wnt/β-catenin and JNK pathways.
 
Dimpy Kalia, Anil Kumar K. S., Gajanand Meena, Kashmir Prasad Sethi, Rohit Sharma, Priyanka Trivedi, Shaheb Raj Khan, Ajay Singh Verma, Shyam Singh, Sandeep Sharma, Kuldeep K. Roy, Ruchir Kant, Manju Yasodha Krishnan, Bhupendra N. Singh, Sudhir Sinha, Vinita Chaturvedi, Anil K. Saxena and Dinesh K. Dikshit
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00131E, Concise Article
Conformationally-constrained and bisquinoline analogs of TMC207 as antitubercular agents.
 
Lili Dong, Suqing Zheng, Yali Zhang, Xin Jiang, Jianzhang Wu, Xiaoqin Zhang, Xiaoou Shan, Dandan Liang, Shilong Ying, Jianpeng Feng and Guang Liang
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00113G, Concise Article
Acute lung injury (ALI), one of a few severe diseases with high mortality, cannot be tackled by any effective therapies so far.
 
Diana Castagna, Emma L. Duffy, Dima Semaan, Louise C. Young, John M. Pritchard, Simon J. F. Macdonald, David C. Budd, Craig Jamieson and Allan J. B. Watson
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD90032H, Correction
 
Narsimha Reddy Penthala, Leena Madhukuri, Shraddha Thakkar, Nikhil Reddy Madadi, Gauri Lamture, Robert L. Eoff and Peter A. Crooks
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00219B, Concise Article
Novel, stable combretastatin-A4 heterocyclic (2H)-1,2,3-triazole analogues displayed potent cytotoxic activity against both hematological and solid tumor cell lines with GI50 values in the low nanomolar range.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD90031J, Correction
 
Nermin S. Abdou, Rabah A. T. Serya, Ahmed Esmat, Mai F. Tolba, Nasser S. M. Ismail and Khaled A. M. Abouzid
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00127G, Concise Article
A novel series of pyrazolo[3,4-d]pyrimidine derivatives were designed, synthesized and evaluated for their antiproliferative activity.
 
Barbara De Filippis, Mariangela Agamennone, Alessandra Ammazzalorso, Isabella Bruno, Alessandra D'Angelo, Mauro Di Matteo, Marialuigia Fantacuzzi, Letizia Giampietro, Antonella Giancristofaro, Cristina Maccallini and Rosa Amoroso
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00151J, Concise Article
A new series of gemfibrozil analogues conjugated with trans-stilbene were synthesized and evaluated with the aim of developing new PPARα agonists.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00228A, Concise Article
Curves showing two different trials of killing a MRSA strain with [Cp*IrCl(cis-1,2-diaminocyclohexane)]Cl.
 
Justyna Sikorska, Luca Codutti, Lars Skjærven, Bettina Elshorst, Rebeca Saez-Ameneiro, Andrea Angelini, Peter Monecke and Teresa Carlomagno
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00116A, Concise Article
INPHARMA, an NMR-based method that determines ligand binding poses, allows finding novel scaffolds as inhibitors of a target protein.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00171D, Concise Article
Compounds 12g, 12i and 12l modulate pro-inflammatory cytokine production by inhibiting monocyte differentiation.
 
Qi Guan, Dongjie Feng, Zhaoshi Bai, Yuanhang Cui, Daiying Zuo, Min'an Zhai, Xuewei Jiang, Wenbo Zhou, Kai Bao, Yingliang Wu and Weige Zhang
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00150A, Concise Article
A microwave-assisted synthesis method of building a 1,2,4-oxadiazole skeleton was developed.
 

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