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MedChemComm

Broadening the field of opportunity for medicinal chemists. Official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.626 12 Issues per Year
 
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DAMIANA DA ROCHA VIANNA, LEILA Ruschel, FABRÍCIA Dietrich, Fabrício Figueiró, Fernanda Morrone, Romulo F. S. Canto, Flávia Corvello, Alice Velho, Allan Crestani, Helder Teixeira, Gilsane Lino von Poser, Ana Maria Oliveira Battastini and Vera Eifler-Lima
Med. Chem. Commun., 2015, Accepted Manuscript
DOI: 10.1039/C5MD00039D, Concise Article
Bladder cancer is one of the most prevalent malignancies of the genitourinary tract, and approximately 25% of patients with superficial cancers develop invasive and metastatic pathology. Coumarins and their derivatives...
 
M. A. Soriano-Ursúa, J. G. Trujillo-Ferrara, J. A. Arias-Montaño and R. Villalobos-Molina
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00011D, Review Article
Putative roles of a secondary binding region shared among beta-adrenoceptors.
 
Ponnam Devendar, Vadithe Lakshma Nayak, Dharmendra Kumar Yadav, Arigari Niranjana Kumar, Jonnala Kotesh Kumar, KVN Satya Srinivas, Balasubramanian Sridhar, Feroz Khan, Kakaraparthi Pandu Sastry and Sistla Ramakrishna
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00566J, Concise Article
Ceric ammonium nitrate facilitates andrographolide-3,19-O-acetal formation with alcohols. Anticancer active derivatives showed good docking scores in in silico.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD90015H, In the Pipeline
Computer-assisted drug design always looks like it's just about to work, says Derek Lowe, but the reality is complicated.
 
Sandra Ferl, Gerd Wunderlich, René Smits, Alexander Hoepping, Anne Naumann and Jörg Kotzerke
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00574K, Concise Article
A new multifunctional compound that includes the fluorescent dye 4′,6-diamidine-2-phenylindole (DAPI) and the chelator 6-hydrazinonicotinic acid (HYNIC) was developed and radiolabelled with 99mTc for in vitro evaluation in an FRTL5 cell line.
 
Oliver Ries, Christian Carnarius, Claudia Steinem and Christian Ducho
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00526K, Concise Article
A simplified model system is introduced to elucidate the significance of the ω-functionalised fatty acid moiety of muraymycin nucleoside antibiotics for membrane interaction and penetration.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD90014J, Editorial
Direct linking to further chemical and biological data.
 
Nellore Bhanu Chandar, Rabindranath Lo, Manoj K. Kesharwani and Bishwajit Ganguly
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00497C, Concise Article
This study revealed that the reactivation of tabun inhibited AChE is feasible with neutral antidotes prior to the aging process.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00536H, Concise Article
Thiourea and nicotinamide-containing sorafenib analogs with better antiproliferative and anti-angiogenic activities than sorafenib were well designed and synthesized.
 
Sören Krawczyk, Christiane Baumert, Joséf Molnár, Christoph Ritter, Jens Höpner, Charlotte Kloft and Andreas Hilgeroth
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00506F, Concise Article
Novel non-substrate modulators of the transmembrane efflux pump P-gp have been profiled as nontoxic and mdr reversing agents.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00560K, Concise Article
3D binding interactions of 7a (magenta-colored carbons) and the co-crystallized ligand (cyan-colored carbons) with the active site amino acids of CHK1.
 
Arnab Bhattacharyya, Akanksha Dixit, Koushambi Mitra, Samya Banerjee, Anjali A. Karande and Akhil R. Chakravarty
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00425F, Concise Article
BODIPY-appended copper(II) complexes of curcumin show a remarkable PDT effect in visible light in HeLa cells via apoptosis with mitochondrial localization.
 
Santosh Kumar Prajapti, Shweta Shrivastava, Umesh Bihade, Ajay Kumar Gupta, V. G. M. Naidu, Uttam Chand Banerjee and Bathini Nagendra Babu
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00525B, Concise Article
Novel Δ2-isoxazoline fused cyclopentane derivatives have been synthesized and evaluated for their antimicrobial and anticancer activities.
 
Yin Chen, Yu Lan, Xudong Cao, Xiangqing Xu, Juecheng Zhang, Minquan Yu, Xin Liu, Bi-Feng Liu and Guisen Zhang
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00578C, Concise Article
A series of amide derivatives of benzisoxazole has been synthesized and the target compounds evaluated for atypical antipsychotic activity in vitro and vivo.
 
Annamaria Panico, Rosanna Maccari, Venera Cardile, Sergio Avondo, Lucia Crascì and Rosaria Ottanà
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00556B, Concise Article
2-Thioxo-4-thiazolidinone derivatives active as aldose reductase inhibitors were able to control key inflammatory/degenerative events induced by IL-1β in human chondrocytes, appearing to be promising candidates in the search for novel anti-inflammatory agents.
 
Quan Van Vuong, Zuzana Bednarikova, Andrea Antosova, Pham Dinh Quoc Huy, Katarina Siposova, Nguyen Anh Tuan, Mai Suan Li and Zuzana Gazova
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5MD00004A, Concise Article
The structure of glyco-acridines determines their impact on insulin amyloid aggregation and newly introduced geometrical descriptors allow us to distinguish different binding affinities.
 
Bing Xu, Yan Gong, Xin Xu, Chenze Zhang, Yuzhong Zhang, Fuhao Chu, Hongbing Liu, Penglong Wang and Haimin Lei
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00552J, Concise Article
The novel ligustrazine derivatives were synthesized and displayed the remarkable protective effect (highest EC50 = 0.719 μM) on PC12 cells damaged by CoCl2.
 
A. Mohsen M. E. Omar, Omaima M. Aboulwafa, Doaa A. E. Issa, May M. S. El-Shokrofy, May E. Amr and Ibrahim M. El-Ashmawy
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00557K, Concise Article
Hypothesis for designing 6-substituted benzothiazolecarbamate prototype anthelmintics having diversities in flexibility and rigidity of substituents with different polar nature and hydrophilic–lipophilic properties.
 
Nikhil R. Madadi, Hongliang Zong, Amit Ketkar, Chen Zheng, Narsimha R. Penthala, Venumadhav Janganati, Shobanbabu Bommagani, Robert L. Eoff, Monica L. Guzman and Peter A. Crooks
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00478G, Concise Article
Novel resveratrol analogues have been synthesized and evaluated for their anticancer activities against a panel of 60 human cancer cell lines.
 
Dilip K. Tosh, Silvia Paoletta, Zhoumou Chen, Steven Crane, John Lloyd, Zhan-Guo Gao, Elizabeth T. Gizewski, John A. Auchampach, Daniela Salvemini and Kenneth A. Jacobson
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00571F, Concise Article
C2-phenylethynyl (dark green) and C2-phenyl-triazolyl (light green) nucleosides in the A3AR.
 
Daniela Rossi, Virpi Talman, Gustav Boije Af Gennäs, Annamaria Marra, Pietro Picconi, Rita Nasti, Massimo Serra, Jihyae Ann, Marialaura Amadio, Alessia Pascale, Raimo K. Tuominen, Jari Yli-Kauhaluoma, Jeewoo Lee and Simona Collina
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00564C, Concise Article
Over the past fifteen years, we reported the design and synthesis of different series of compounds targeting the C1 domain of protein kinase C (PKC) that were based on various templates.
 
Kavita Yadav, Priyanshu Bhargava, Sandhya Bansal, Manish Singh, Siddhi Gupta, Geeta Sandhu, Sandeep Kumar, Vedagopuram Sreekanth and Avinash Bajaj
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00289J, Concise Article
Anticancer drug Tamoxifen is modified to charged lithocholic acid derived amphiphile for enhanced cytotoxicity against breast cancer cells.
 
R. Elancheran, V. L. Maruthanila, M. Ramanathan, S. Kabilan, R. Devi, A. Kunnumakara and Jibon Kotoky
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00416G, Review Article
The main focus of this review is to discuss the discoveries and developments of various therapies for prostate cancer.
 
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00481G, Concise Article
We have developed for the first time an excellent targeted metallic single component nanoparticle system for combination of PDT and chemotherapy.
 
Xin Zhao, Zhen-Wei Zhang, Wei Cui, Shengwei Chen, Yang Zhou, Jianghong Dong, Yanling Jie, Junting Wan, Yong Xu and Wenhui Hu
Med. Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4MD00515E, Concise Article
Amantadine derivatives have been the only drugs marketed as M2 inhibitors of influenza A for decades.
 

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