Publishing: Journals, books and databases
Journal cover: MedChemComm

MedChemComm

Research and review articles in medicinal chemistry and related drug discovery science; the official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.495 12 Issues per Year
 
  • Advance Articles
  • |
  • Accepted Manuscripts
  • |
  • All Recent Articles
Prev Pg 1 of 3 Next
Frederick W Goldberg, Paula Daunt, Stuart Pearson, Ryan Greenwood, Matthew Grist and Judit Debreczeni
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00039H, Research Article
A novel class of N-(4-anilino-2-pyridyl)amide based activin receptor-like kinase (ALK1) inhibitors are disclosed, which were rapidly optimised to a ligand efficient probe compound 21 with good potency in enzyme (4...
 
Bruno Junior Neves, Rafael Ferreira Dantas, Mario Roberto Senger, Walter César Góes Valente, João de Mello Rezende-Neto, Willian Távora Chaves, Lee Kamentsky, Anne Carpenter, Floriano Paes Silva-Junior and Carolina Horta Andrade
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00596E, Research Article
Paroxetine is a new anti-schistosomal lead with potent activity against schistosomula and adult life stages of S. mansoni.
 
Clément Morgat, Raunak Varshney, Delphine Vimont, Catherine Savona-Baron, Colette Ries, Christel Chanseau, Sandrine Bertrand, Anil K Mishra, Elif Hindié, Philippe Fernandez and Jurgen Schulz
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00131A, Research Article
Neuromedin B receptor (NMB-R) is a promising target in several human processes, for instance thymic carcinoma, intestinal carcinoids but also pruritus, etc. NMB-R Positron Emission Tomography (PET) molecular imaging may...
 
Lei Zhang, Kecheng Lei, Jingwen Zhang, Wenlin Song, Yuanhong Zheng, Shaoying Tan, Yuwei Gao, Yufang Xu, Jianwen Liu and Xuhong Qian
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00104A, Research Article
A small single-molecule theranostic agent based on naphthalimide was developed, which possessed both bright fluorescence imaging and effective photodynamic therapeutic treatment.
 
A. Venkanna, Ch. Pavan Kumar, B. Poornima, Bandi Siva, Nishant Jain and K. Suresh Babu
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00097E, Research Article
From themed collection 2016 MedChemComm Hot Articles
A series of schisantherin A (1) derivatives were efficiently synthesized utilizing Yamaguchi esterification (2,4,6-trichlorobenzoyl chloride, Et3N, THF, DMAP, toluene) at the C-7′ position of the schisantherin A core.
 
Xia Tian, Gregory S. Basarab, Nidhal Selmi, Thierry Kogej, Ying Zhang, Matthew Clark and Robert A. Goodnow Jr.
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00088F, Research Article
The tertiary amino effect reaction was explored and developed for application to DNA-encoded library synthesis.
 
Gopal Chandru Senadi, Chieh-Ming Liao, Kung-Kai Kuo, Jian-Cheng Lin, Long-Sen Chang, Jeh Jeng Wang and Wan-Ping Hu
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00034G, Research Article
We have designed and synthesized a new series of 1-benzothiazolylphenylbenzotriazoles 9a–p and studied their antimetastatic mechanism involved in photosensitive effects induced by UVA in oral cancer cell Ca9-22.
 
René Blöcher, Christina Lamers, Sandra K. Wittmann, Olaf Diehl, Thomas Hanke, Daniel Merk, Dieter Steinhilber, Manfred Schubert-Zsilavecz, Astrid S. Kahnt and Ewgenij Proschak
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00042H, Research Article
From themed collection New Talent: Europe
Metabolic syndrome (MetS) is a widespread, complex disease cluster which consists of hypertension, atherosclerosis, dyslipidaemia and type II diabetes. The treatment of MetS requires multiple pharmaceutical agents leading to complex...
 
Mateusz Daśko, Maciej Masłyk, Konrad Kubiński, Justyna Aszyk, Janusz Rachon and Sebastian Demkowicz
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00113K, Research Article
In the present work, we report convenient methods for the synthesis and biological evaluation of N-phosphorylated derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as potential steroid sulfatase (STS) inhibitors.
 
Hai-Rong Zhang, Ke-Bin Huang, Zhen-Feng Chen, Yan-Cheng Liu, You-Nian Liu, Ting Meng, Qi-Pin Qin, Bi-Qun Zou and Hong Liang
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00073H, Research Article
Three cobalt(II) complexes with 8-hydroxyquinoline derivatives as ligands were synthesized. They exhibited strong proliferation inhibition activity against T-24 cancer cells, which induced cancer cell apoptosis via intrinsic caspase-mitochondria pathways.
 
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00012F, Review Article
Interactions between biologically active compounds and their targets often involve hydrophobic interactions, and hydrophobicity also influences the pharmacokinetic profile. Nevertheless, comparatively little attention has been given to utilization of hydrophobic...
 
Hua-Hong Zou, Jun-Guang Wei, Xiao-Huan Qin, Shun-Gui Mo, Qi-Pin Qin, Yan-Cheng Liu, Fu-Pei Liang, Yun-Liang Zhang and Zhen-Feng Chen
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00098C, Research Article
Two metallo-complexes inhibited telomerase by interacting with c-myc G4-DNA and induced cell cycle arrest at the S phase.
 
E. Lattmann, S. T. Russell, C. H. Schwalbe, A. Shortt, P. N. Balaram, E. Theochari, M. Alharbi, R. Narayanan and P. Lattmann
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00052E, Research Article
Hydroxy-pyrrolones, which were potent CCK1R antagonists, showed nanomolar in vitro activity and anticancer activity in vivo for colon and pancreatic cancer.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00138F, Research Article
Knowledge of the physical form at the end of the assay allows the solubility results to be put into context.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00109B, Research Article
From themed collection 2016 MedChemComm Hot Articles
We demonstrate the application of a controllable drug delivery system, where an active and toxic imidazolium salt can be camouflaged when assembled as an inclusion complex with cyclodextrins.
 
Claire Colas, Peter Man-Un Ung and Avner Schlessinger
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00005C, Review Article
From themed collection 2016 MedChemComm Hot Articles
The human solute carrier (SLC) transporters are important targets for drug development.
 
Ravindra M. Kumbhare, Tulshiram L. Dadmal, Dinesh Kumar, janki ramana, Anudeep Kota, Debabrata chowdhury chowdhury, killari appalanaidu, Y. Khageswara Rao, Sayyad Hyder, T. Anjana Devi and Manika Pal Bhadra
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C5MD00603A, Research Article
A series of 2-imino-4-(trifluoromethyl)thiazolidin-4-ol derivatives were synthesized from one pot, three component reactions of primary amine, aryl isothiocyanate and 3-bromo-trifluoromethyl acetone via in situ generation of both symmetrical and unsymmetrical...
 
Tao Zhou, Le-Le Shao, Sinan Battah, Chun-Feng Zhu, Robert Hider, Brandon Reeder, Asma Jabeen, Sandy MacRobert, Gerui Ren and Xinle Liang
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00040A, Research Article
5-Aminolaevulinic acid (ALA) and its derivatives have been widely used in photodynamic therapy (PDT) as precursors of the photosensitizer, protoporphyrin IX (PpIX) in dermatology and urology. However, ALA–PDT is limited...
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00572H, Review Article
From themed collection Membrane Transporters: Solute Carriers; Guest Edited by Prof Matthias A. Hediger & Dr David Hepworth
This article reviews the role of segments of SLCs located outside the plasma membrane bilayer (ectodomains) using the inhibition of SGLTs (SLC5 family) by the aromatic glucoside phlorizin as a model system.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00130K, Research Article
Screening and subsequent medicinal chemistry gave a new chemotype for hICMT inhibitors.
 
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00121A, Research Article
Drug development targeting fibroblast growth factor receptors (FGFRs) represents an emerging theme in the field of medicinal chemistry. Considering the fact that most of the currently identified FGFR agonists are...
 
Shobith Rangappa, Gerard Artigas, Risho Miyoshi, Yasuhiro Yokoi, Shun Hayakawa, Fayna Garcia-Martin, Hiroshi Hinou and Shin-Ichiro Nishimura
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00100A, Research Article
From themed collection 2016 MedChemComm Hot Articles
The conformational impact of the clustered O-glycans strongly influences recognition by antibodies of the cancer-relevant epitope in the MUC1 extracellular tandem repeat domain.
 
Dagmar Stumpfe and Jürgen Bajorath
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00108D, Review Article
Shown is a section of an SAR network. Nodes represent compounds and are colored by potency and edges indicate pair-wise similarity relationships.
 
Vigneshwari Subramanian, Peteris Prusis, Henri Xhaard and Gerd Wohlfahrt
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00556F, Research Article
Proteochemometric models of kinases derived from protein fields and ligand 4-point pharmacophoric fingerprints are predictive and visually interpretable.
 
Masayori Hagimori, Takahiro Murakami, Kinue Shimizu, Motohiro Nishida, Takashi Ohshima and Takahiro Mukai
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00023A, Research Article
The transient receptor potential canonical 3 (TRPC3) channel is a member of the TRPC family that contributes to the entry of Ca2+ through the plasma membrane or modulates the driving force for Ca2+ entry channels.
 

Search this journal

Find an issue

MedChemComm (2010-Present)
Year *
Issue

Find an article

Journal*
Year*
Page 

Related news

We’re about to publish our first new issue of 2016 and with it come some changes to the journal which we hope will enhance MedChemComm for our readers...
MedChemComm Blog 14 Jan 2016
We are pleased to announce that nominations for the 2016 MedChemComm Emerging Investigator Lectureship are now open and we are looking for your sugges...
MedChemComm Blog 10 Dec 2015
Register for the ABPI R&D Conference 2015 and come and browse our drug discovery books at the RSC booth. This year the event will address the foll...
RSC Books Blog 29 Oct 2015
The articles below are the most read MedChemComm articles in July, August and September 2015. Transition metal diamine complexes with antimicrobial ac...
MedChemComm Blog 29 Oct 2015