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Journal cover: MedChemComm

MedChemComm

Research and review articles in medicinal chemistry and related drug discovery science; the official journal of the European Federation for Medicinal Chemistry
 
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Wen Hou, Hui Lin, Zhen-Ya Wang, Martin G. Banwell, Ting Zeng, Ping-Hua Sun, Jing Lin and Wei-Min Chen
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00563B, Research Article
A series of novel bivalent securinine mimetics incorporating different linkers between C-15 and C-15′ were synthesized and their topoisomerase I (Topo I) inhibitory activities evaluated.
 
Thi Dao Phi, Huong Doan Thi Mai, Van Hieu Tran, Bich Ngan Truong, Tuan Anh Tran, Van Loi Vu, Van Minh Chau and Van Cuong Pham
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00587J, Research Article
The C-2′ of the lactam rings and the flexibility of polyketide chain should be critical for the cytotoxicity of bengamides.
 
Gudikadi Linga Goud, Seela Ramesh, Dongamanti Ashok, Vummenthala Prabhakar Reddy, Perumal Yogeeswari, Dharmarajan Sriram, Balabadra Saikrishna and Vijjulatha Manga
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00593D, Research Article
As part of an ongoing effort to develop new antitubercular and antimicrobial agents, a series of substituted xanthenone derivatives (7a–p) were synthesized.
 
Med. Chem. Commun., 2017, Accepted Manuscript
DOI: 10.1039/C6MD00670A, Research Article
Human lactate dehydrogenase A (LDHA) plays a crucial role in the promotion of glycolysis in invasive tumor cells. Recently, it has been considered as a vital therapeutic target in oncology...
 
Med. Chem. Commun., 2017, Accepted Manuscript
DOI: 10.1039/C6MD00377J, Research Article
Inhibition of the Hsp90 C-terminus is an attractive therapeutic paradigm for the treatment of cancer, however the developmental space of C-terminal inhibitors is limited. It was hypothesized that the combination...
 
Med. Chem. Commun., 2017, Accepted Manuscript
DOI: 10.1039/C6MD00647G, Research Article
In analogy to the natural product chelerythrine, which has been identified as inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), we prepared a small series of 8-hydroxy-2,7-naphthyridin-2-ium salts. Spectroscopic analyses...
 
Med. Chem. Commun., 2017, Accepted Manuscript
DOI: 10.1039/C6MD00612D, Review Article
A review. We introduced group Ⅱ and group Ⅲ PAMs/NAMs and agonists/antagonists reported over the past five years, with a focus on their biological activity and selectivity. In particular,the structure...
 
Jing Zhang, Kun Qian, Chunli Yan, Maomao He, Brenson A. Jassim, Ivaylo Ivanov and Yujun George Zheng
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00573J, Research Article
This report presents the synthesis and evaluation of compound decamidine as a potent inhibitor for protein arginine methyltransferase 1 (PRMT1).
 
Chandradhish Ghosh, Shweta Chaubey, Utpal Tatu and Jayanta Haldar
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00589F, Research Article
Water-soluble membrane-active compounds, that are active against Plasmodium sp. both in vitro and in vivo are reported.
 
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00607H, Review Article
Bacteriocins are potent antimicrobial peptides that are ribosomally produced and exported by bacteria, presumably to aid elimination of competing microorganisms.
 
Hua Xu, Lee R. Roberts, Song Chou, Betsy Pierce, Arjun Narayanan and Lyn H. Jones
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00633G, Research Article
From themed collection New Talent: Americas
We developed a transcylcooctene-based chemical probe for quantitative measurement of intracellular HDAC1/2 occupancy.
 
Raquel Mello da Rosa, Bruna Candia Piccoli, Fernanda D'Avila da Silva, Luciano Dornelles, João B. T. Rocha, Mariana Souza Sonego, Karine Rech Begnini, Tiago Collares, Fabiana K. Seixas and Oscar E. D. Rodrigues
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00640J, Research Article
This article presents the preparation and in vitro biological activities of new 5′;-arylchalcogeno-3-aminothymidine derivatives as antioxidants as well as antitumoral agents against bladder carcinoma 5637.
 
Yu Tahara, Takuma Yoshikawa, Hikari Sato, Yukina Mori, Md Hosain Zahangir, Akihiro Kishimura, Takeshi Mori and Yoshiki Katayama
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00614K, Research Article
We propose a method to improve the enhanced permeability and retention (EPR) effect of nanomedicines based on tumor-specific vasodilation using a nitric oxide (NO) donor-containing PEGylated liposome.
 
L. Legnani, D. Colombo, A. Venuti, C. Pastori, L. Lopalco, L. Toma, M. Mori, G. Grazioso and S. Villa
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00575F, Research Article
Two diazabicyclo analogues of maraviroc, in which the azabicyclooctane moiety is replaced by diazabicyclooctane or diazabicyclononane, were synthesized and tested, through a viral neutralization assay, on a panel of six pseudoviruses.
 
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00569A, Review Article
An original point of view inside the SAR studies to develop new selective COX-2 inhibitors.
 
Yifan Zhang, Yuncai Guan, Sizhan Ge, Ahu Yuan, Jinhui Wu and Yiqiao Hu
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00625F, Research Article
A polymeric micelle system decomposes into CO2 bubbles and ablates tumor cells without loading any drug.
 
R. Venkateshwarlu, B. Chinnababu, U. Ramulu, K. Purushotham Reddy, M. Damoder Reddy, P. Sowjanya, P. Venkateswara Rao and S. Aravind
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00606J, Research Article
Stereoselective synthesis of (−)-kunstleramide and its amide derivatives has been achieved and they have been evaluated for their in vitro anti-proliferative activities against various cell lines.
 
Jin-Shuai Lan, TONG ZHANG, Yun Liu, Yong Zhang, Jian-wei Hou, Sai-sai Xie, Jing Yang, Yue Ding and Zhen-zhen Cai
Med. Chem. Commun., 2017, Accepted Manuscript
DOI: 10.1039/C6MD00586A, Research Article
A new series of small molecules bearing the benzyloxy substituent have been designed, synthesized and evaluated for hMAO inhibitory activity in vitro. Most of compounds were potent and selective MAO-B...
 
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00696E, Research Article
Here we report the feasibility of using a high-affinity histone H1-binding peptide as a potential molecular apoptosis imaging probe.
 
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00536E, Research Article
A series of peptide nucleic acids containing 5-halouracils have been synthesized using the Fmoc protection strategy, and their enhanced hybridizations have been studied.
 
Jamshed Iqbal, Mobasher Abid, Sana Aslam, Sumera Zaib, Mahwish Bakht, Matloob Ahmad, Muhammad Makshoof Athar and John M. Gardiner
Med. Chem. Commun., 2017, Accepted Manuscript
DOI: 10.1039/C6MD00570E, Research Article
Two new series of pyrazolobenzothiazine-based carbothioamides (3a-o) and (4a-o) were synthesized using saccharine as starting material. Synthesized derivatives were investigated for their ability to inhibit monoamine oxidases (MAO). Compound 3b...
 
Ryo Kunimoto, Martin Vogt and Jürgen Bajorath
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00628K, Research Article
Chemical space network (CSN). Shown is a CSN with asymmetric similarity relationships in which an optimization-relevant compound pathway is traced (red).
 
Azadeh Hashem Nia, Behzad Behnam, Sahar Taghavi, Fatemeh Oroojalian, Hossein Eshghi, Wayne T. Shier, Khalil Abnous and Mohammad Ramezani
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00481D, Research Article
Efficient delivery of pDNA using SWNT–succinate–PEI conjugates.
 
R. Moslin, D. Gardner, J. Santella, Y. Zhang, J. V. Duncia, C. Liu, J. Lin, J. S. Tokarski, J. Strnad, D. Pedicord, J. Chen, Y. Blat, A. Zupa-Fernandez, L. Cheng, H. Sun, C. Chaudhry, C. Huang, C. D'Arienzo, J. S. Sack, J. K. Muckelbauer, C. Chang, J. Tredup, D. Xie, N. Aranibar, J. R. Burke, P. H. Carter and D. S. Weinstein
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00560H, Research Article
From themed collection 2016 MedChemComm Hot Articles
Synthesis and SAR of selective ligands of the pseudokinase domain of the Janus kinase (JAK) TYK2 are first reported herein.
 
Jianxia Li, Jieqiong Dong, Jie Ouyang, Jie Cui, Yuan Chen, Fengjun Wang and Jianzhong Wang
Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C6MD00496B, Research Article
We successfully synthesised an efficient, water-soluble, nontoxic, and high antioxidant activity dihydroquercetin derivative (DHQA) by aminomethylation reaction.
 

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17 citations
A new series of exceptionally potent quinoline derivatives 6–30 as α-glucosidase inhibitors was identified.
DOI: 10.1039/C5MD00280J
Published: 21 Aug 2015
2 citations
New antimycobacterial 2-(quinoline-4-yloxy)acetamides were prepared, and using gene deletion and resistant mutants, we conclude that the compound class inhibits the mycobacterial cytochrome bc1 complex.
DOI: 10.1039/C6MD00236F
Published: 22 Aug 2016
18 citations
A library of thirty one 1,2,3-triazole derivatives efficiently prepared via click chemistry and evaluated for their antitubercular, antioxidant, and cytotoxic activities.
DOI: 10.1039/C5MD00057B
Published: 12 May 2015

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