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MedChemComm

Research and review articles in medicinal chemistry and related drug discovery science; the official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.319 12 Issues per Year
 
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Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00336B, Research Article
Exposure of plasma to iron and carbon monoxide (CO) renders fibrinogen resistant to fibrinogenolytic or thrombin-like activity contained in pit viper venom. However, the direct effects of iron/CO on venom...
 
Xu Han, Yongying Shi, Longlong Si, Zibo Fan, Han Wang, Renyang Xu, Pingxuan Jiao, Kun Meng, Zhenyu Tian, Xiaoshu Zhou, Hongwei Jin, Xinyu Wu, Hong Chen, Yongmin Zhang, Lihe Zhang, Sulong Xiao and Demin Zhou
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00292G, Research Article
A total of 24 novel sialic acid–pentacyclic triterpene conjugates were synthesized and evaluated as anti-influenza virus entry inhibitors.
 
Sharan K. Bagal, Mark I. Kemp, Peter J. Bungay, Tanya L. Hay, Yoshihisa Murata, C. Elizabeth Payne, Edward B. Stevens, Alan Brown, David C. Blakemore, Matthew S. Corbett, Duncan C. Miller, Kiyoyuki Omoto and Joseph S. Warmus
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00281A, Research Article
Potent and subtype selective Nav1.8 inhibitors were designed and optimised for selectivity over hERG ion channel inhibition.
 
Rune Nørgaard Rasmussen, René Holm, Kenneth Vielsted Christensen and Carsten Uhd Nielsen
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00305B, Research Article
From themed collection Membrane Transporters: Solute Carriers; Guest Edited by Prof Matthias A. Hediger & Dr David Hepworth
An ibuprofen transporter localizes to the apical and basolateral membrane of MDCK I cells is upregulated by hyperosmotic exposure. Ibuprofen uptake is inhibited by other NSAIDs and ibuprofen metabolites.
 
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00365F, Research Article
A library of 33 compounds was screened for potentiation of the antibiotic FR 900098 against the Francisella tularensis surrogate Francisella novicida. From the screen a highly potent 2-oxazoline adjuvant was...
 
Andreas Brunschweiger, Mateja Klika Škopić, Olivia Bugain, Kathrin Jung, Svenja Onstein, Sven Brandherm and Tuomo Kalliokoski
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00243A, Research Article
From themed collection DNA Encoded Libraries
Selection-based screening of large DNA-encoded libraries of drug-like small molecules is a validated method to identify bioactive compounds. Among the chemical space of bioactive compounds certain scaffold structures are well...
 
Wenzhen Liao, Longjian Gu, Yamei Zheng, Zisheng Zhu, Mou-Ming Zhao, Ming Liang and Jiaoyan Ren
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00006A, Research Article
In the present study, eleven glutathione-derived peptides, including Glu-Cys-His, Pro-Leu-Gly, Pro-Cys-Gly, Phe-Lys-Leu, Leu-His-Gly, Lys-Leu-Glu, Lys-Val-His, Tyr-Glu-Gly, Tyr-His-Leu, Gly-Glu-Leu and Gly-Pro-Glu, were designed. The antioxidant activity of these peptides was investigated...
 
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00381H, Research Article
Herein, we disclose the development of a catalyst- and protecting-group-free microwave-enhanced Friedländer synthesis which permits the single-step, convergent assembly of diverse 8-hydroxyquinolines with greatly improved reaction yields over traditional oil...
 
Christopher Tinworth, Hannah Lithgow and Ian Churcher
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00347H, Review Article
The concept of using peptidic bifunctional molecules to allow recruitment of ubiquitin E3 ligases to induce the degradation of specific intracellular proteins was first demonstrated in 2001 but, following the...
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00340K, Review Article
This review focuses on novel classes of natural products whose structures have not yet been thoroughly explored for medicinal chemistry purposes. These novel chemotypes may be useful starting points to develop compounds that alter Hsp90 function via novel mechanisms.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00300A, Research Article
The P-gp induction activity of SR12813 and its analogs has been reported.
 
Koneni V. Sashidhara, K. Bhaskara Rao, Ravi Sonkar, Ram K. Modukuri, Yashpal S. Chhonker, Pragati Kushwaha, Hardik Chandasana, A. K. Khanna, Rabi S. Bhatta, Gitika Bhatia, Manish Kumar Suthar, Jitendra Kumar Saxena, Vikash Kumar and Mohammad Imran Siddiqi
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00283H, Research Article
Lipid lowering activity of novel coumarin–indole hybrids has been demonstrated.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00341A, Review Article
From themed collection DNA Encoded Libraries
Innovation incubation: DNA encoded library technology (ELT) was invented in academia and biotech, but came of age in a big pharma environment.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00296J, Review Article
The increasingly sophisticated array of approaches for the specific labeling and fluorescence-based detection of carbonic anhydrase enzymes using small molecule affinity-based chemical probes is reviewed.
 
Kang Chang, Yanxia Shi, Jianqin Chen, Zenghui He, Zheng Xu, Zhenjiang Zhao, Weiping Zhu, Honglin Li, Yufang Xu, BaoJu Li and Xuhong Qian
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00261G, Research Article
A series of novel plant activators possessing a pyrrolidone scaffold was developed with the help of SHAFTS.
 
Jia Wang, xiaoyang Fan, Li-Yun Yang, Huan He, Rong Huang, Feng-Lei Jiang and Yi Liu
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00268D, Research Article
5-fluorouracil (5-FU) was linked with F16 by vulnerable bonds for selectively targeting cancer mitochondria and resulted in conjugated compounds including F16-5-FU, F16-OOC-FU, F16-NHOC-FU and F16-SS-FU. F16-OOC-FU decreased the antiproliferative activicty...
 
Mahyar Bonsaii, Khodayar Gholivand, Khosrou Abdi, Ali Asghar Ebrahimi valmoozi and Morteza Khosravi
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00264A, Research Article
A complex of Co(III) with five ammine ligands and a bis(2-chloroethyl)amine moiety was prepared in an effort to understand the mechanisms of interaction of nitrogen mustards with DNA. The activity...
 
Dnyaneshwar D. Subhedar, Mubarak H. Shaikh, Bapurao B. Shingate, Laxman Nawale, Dhiman Sarkar and Vijay M. Khedkar
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00278A, Research Article
Synthesis of new tetrazoloquinoline–thiazolidinone conjugates were achieved via one-pot three-component cyclocondensation in the presence of [DBUH][OAc] and studied antitubercular activity.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00207B, Research Article
From themed collection Membrane Transporters: Solute Carriers; Guest Edited by Prof Matthias A. Hediger & Dr David Hepworth
Retrieval of consistent SAR data sets is a challenging task. Combining integrated open data sources with workflow tools allows studying selectivity trends of compound series.
 
Rupinder Gill, Ramandeep Brar, Virender Kumar, Vivek Gupta, Gagandeep Singh and Jitender Bariwal
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00256K, Research Article
In the present study, 2-phenyl/2-phenylethynyl-3-aroyl thiophenes have been designed and synthesized via microwave assisted methods. All the synthesized compounds were evaluated for in vitro antiproliferative activity against various human cancer...
 
Noorul Adawiyah, Muhammad Moniruzzaman, Siti Hawatulailaa and Masahiro Goto
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00358C, Review Article
The pharmaceutical industries face a series of challenges in the delivery of many newly developed drug molecules because of their low solubility, bioavailability, stability and polymorphic conversion. These limitations are...
 
Jinbao Xiang, Zhuoqi Zhang, Renzhong Fu, Robert Ternansky, Patricia Gladstone, Amy Allan, Fernando Donate, Graham Parry, Jose Juarez, Andrew Mazar and Xu Bai
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00351F, Research Article
An efficient strategy for the discovery of kinase inhibitors by combination of diversity-oriented synthesis and selective screening is described. Initially, a set of 10 compounds representing a 10-scaffold library of...
 
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00297H, Review Article
A tiny population of tumor cells presented in solid and hematologic malignancies, which is responsible for cancer development, metastasis and limited response to therapy is referred to as cancer stem...
 
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00215C, Research Article
A series of findings suggest that the discovery of in vivo apoptosis inducers for chemotherapyis of clinical importance. Based on the analyses of the pharmacophores of in vitro apoptosis inducers,...
 
Dinesh Addla, Si-Qi Wen, Wei-Wei Gao, Swetha K. Maddili, Ling Zhang and Cheng-He Zhou
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00357E, Research Article
A series of novel carbazole aminothiazoles as new type of antimicrobial agents were designed, synthesized and characterized by 1H NMR, 13C NMR, IR, MS and HRMS spectra. Some of the...
 

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Articles from this journal that are regularly and recently being cited by others. We are trialling this feature to see if it makes it quicker and easier for you to find articles for your research. Read more about how we have created this filtering system.

11 citations
A new series of exceptionally potent quinoline derivatives 6–30 as α-glucosidase inhibitors was identified.
DOI: 10.1039/C5MD00280J
Published: 21 Aug 2015
8 citations
The newest information (2010-present) on the four main mechanisms of resistance to the broad-spectrum aminoglycoside antibiotics is presented in details.
DOI: 10.1039/C5MD00344J
Published: 21 Sep 2015
19 citations
Chemically modified antisense oligonucleotides have shown persistent value both in the terms of their success as approved drugs and seminal findings, leading to numerous potential drug candidates in clinical trials.
DOI: 10.1039/C4MD00184B
Published: 01 Aug 2014

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