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MedChemComm

Research and review articles in medicinal chemistry and related drug discovery science; the official journal of the European Federation for Medicinal Chemistry
Impact Factor 2.495 12 Issues per Year
 
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Pratima P. Mogle, Rohan J. Meshram, Shrikant V. Hese, Rahul D. Kamble, Sonali S. Kamble, Rajesh N. Gacche and Bhaskar S. Dawane
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00085A, Research Article
Substituted 2-(2-(5-(3/4-substituted phenyl)-4-hydroxy-3′-(3/4-substituted phenyl)-1′-phenyl-1H,1′H-[3,4′-bipyrazol]-1-yl)thiazol-4(5H)ylidene) hydrazinecarbothioamide derivatives have been synthesized in good yields by an efficient method.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00239K, Research Article
Encapsulation of camptothecin by cucurbit[7]uril significantly inhibited the systemic toxicities of the free drug, while maintaining its antitumor/anti-angiogenic activities.
 
Dominik Nabergoj, Sanja Vrbek, Nace Zidar, Tihomir Tomašić, Danijel Kikelj, Lucija Peterlin Mašič and Christian D. Muller
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00163G, Research Article
Activation of apoptosis in cancer cells could stop the development of several cancers.
 
Arun Kumar, Akanksha Dixit, Samya Banerjee, Arnab Bhattacharyya, Aditya Garai, Anjali A. Karande and Akhil R. Chakravarty
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00071A, Research Article
Targeted PDT by 1O2 at mtDNA crosslinking site of a BODIPY-appended VO2+ complex in visible light.
 
Amir H. Nasiri, Krishna Saxena, Jan W. Bats, Hamid R Nasiri and H Schwalbe
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00262E, Research Article
Doramapimod (BIRB 796) is a potent inhibitor of p38α mitogen-activated protein kinase. It contains an aryl-pyrazole scaffold as a pharmacophore critical for binding. The aryl-pyrazole scaffold is not planar and...
 
Yue Wu, Nan Wang, Yonghua Lei, Tianhan Hu, Qidong You and Xiaojin Zhang
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00240D, Review Article
Patients with chronic kidney diseases (CKD) always suffer from anemia with severely impact on their life quality. Erythropoiesis-stimulating agents (ESAs) are the main drugs in clinical therapy. However, the side...
 
Michael J. Austin, Stephen J. Hearnshaw, Lesley A. Mitchenall, Paul J. McDermott, Lesley A. Howell, Anthony Maxwell and Mark Searcey
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00229C, Research Article
Simocyclinone D8 served as a natural product inspiration for the synthesis of a new DNA gyrase inhibitor.
 
Huy X. Ngo, Sylvie Garneau-Tsodikova and Keith D. Green
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00222F, Review Article
The identification, location, generation, and isolation of new antifungal compounds from their caches in Nature is examined for the years 2010–2016.
 
Margarida Estudante, Graça Soveral, José G. Morais and Leslie Z. Benet
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00188B, Review Article
From themed collection Membrane Transporters: Solute Carriers; Guest Edited by Prof Matthias A. Hediger & Dr David Hepworth
SLCs transport many endogenous and exogenous compounds including drugs; SLCs dysfunction has implications in pharmacokinetics, drug toxicity or lack of efficacy.
 
Teli Liu, Qianqian Gan, Junbo Zhang, Zhonghui Jin, Weifang Zhang and Yanyan Zhang
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00127K, Research Article
99m TcN-3b can be prepared from a kit without the need for purification and would be a promising tumor imaging agent.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00149A, Research Article
Biological applications of homoleptic Ru(III) compounds towards molecular docking, DNA-binding and DNA cleavage.
 
Samara Bahia, Wallace Reis, Guilherme Jardim, Francielly Souto, Carlos Simone, Claudia C Gatto, Rubem F. S. Menna-Barreto, Solange de Castro, Bruno Cavalcanti, Cláudia Pessoa, Maria Helena Araujo and Eufranio Silva Junior
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00216A, Research Article
Quinonoid compounds based on 5-iodo-1,4-disubstituted-, 1,4- and 1,5-disubstituted-1,2,3-triazoles were synthesized using simple methodologies and evaluated against T. cruzi, the etiological agent of Chagas disease, and cancer cell lines: PC3, HCT-116,...
 
Zong-liang Liu, Ren-mei Zhang, Qing-guo Meng, Xiao-chen Zhang and Yuan Sun
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00189K, Research Article
Protein kinase CK2 (CK2) serves as an attractive anticancer target. Herein new CK2 inhibitors with a 1,3-dioxo-2,3-dihydro-1H-indene core are reported.
 
Biljana Đ. Glišić, Nada D. Savić, Beata Warżajtis, Lidija Djokic, Tatjana Ilic-Tomic, Marija Antić, Slavko Radenković, Jasmina Nikodinovic-Runic, Urszula Rychlewska and Miloš I. Djuran
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00214E, Research Article
Dinuclear Au(III) complexes with N-heterocycles have been synthesized and biologically evaluated.
 
R. Navakauskienė, M. Mori, M. S. Christodoulou, A. Zentelytė, B. Botta, L. Dalla Via, F. Ricci, G. Damia, D. Passarella, C. Zilio and N. Martinet
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00170J, Research Article
Histone H3 methylation on K9 and/or K27 depends on histone lysine methyltransferases (KMTs).
 
D. Digles, B. Zdrazil, J.-M. Neefs, H. Van Vlijmen, C. Herhaus, A. Caracoti, J. Brea, B. Roibás, M. I. Loza, N. Queralt-Rosinach, L. I. Furlong, A. Gaulton, L. Bartek, S. Senger, C. Chichester, O. Engkvist, C. T. Evelo, N. I. Franklin, D. Marren, G. F. Ecker and E. Jacoby
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00065G, Research Article
Six computational protocols to annotate phenotypic screens.
 
Angeliki-Sofia Foscolos, Ioannis Papanastasiou, George B. Foscolos, Andrew Tsotinis, Tahsin F. Kellici, Thomas Mavromoustakos, Martin C. Taylor and John M. Kelly
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00035E, Research Article
A range of hydrazones of 5-nitro-2-furaldehyde with adamantane alkanohydrazides was synthesized and their trypanocidal activity was evaluated.
 
Med. Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6MD00178E, Research Article
Abstract This work aimed to isolation, chemical characterization and apoptotic potential of small molecules from the methanol extract of the marine brown algae Padina gymnospora collected from the Mandapam coast....
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00167J, Research Article
A purpose-designed anthraquinone–monoclonal antibody (anti-sialyl Lewis A (sLea) mAb) hybrid 6 selectively bound to and effectively degraded the target glycoprotein, HSA (human serum albumin)–sLea conjugate 4.
 
C. Morgat, R. Varshney, D. Vimont, C. Savona-Baron, C. Riès, C. Chanseau, S. S. Bertrand, A. K. Mishra, E. Hindié, P. Fernandez and J. Schulz
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00131A, Research Article
The neuromedin B receptor NMB-R is frequently over-expressed in tumors of the lung, pancreas, colon, carcinoids (bronchial, intestinal) and also pruritus. We have developed a new class of radiopeptide for NMB-R targeting.
 
Liming Shao, Una C. Campbell, Q. Kevin Fang, Noel A. Powell, John E. Campbell, Philip G. Jones, Taleen Hanania, Vadim Alexandrov, Irene Morganstern, Emily Sabath, Hua M. Zhong, Thomas H. Large and Kerry L. Spear
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00128A, Research Article
A mouse-based assay (SmartCube) was used for both screening and lead optimization of a novel antipsychotic.
 
R. Blöcher, C. Lamers, S. K. Wittmann, O. Diehl, T. Hanke, D. Merk, D. Steinhilber, M. Schubert-Zsilavecz, A. S. Kahnt and E. Proschak
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00042H, Research Article
From themed collection New Talent: Europe
Metabolic syndrome (MetS) is a widespread, complex disease cluster which consists of hypertension, atherosclerosis, dyslipidaemia and type II diabetes.
 
Frederick W. Goldberg, Paula Daunt, Stuart E. Pearson, Ryan Greenwood, Matthew Grist and Judit É. Debreczeni
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00039H, Research Article
A probe compound is described to inhibit ALK1, a target of interest for oncology due to its connection to angiogenesis.
 
Ravindra M. Kumbhare, Tulshiram L. Dadmal, Dinesh Kumar, M. Janaki Ramaiah, Anudeep Kota, Debabrata Chowdhury, K. Appalanaidu, Y. Khageswara Rao, Sayyad Hyder, T. Anjana Devi and Manika Pal Bhadra
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5MD00603A, Research Article
Fluorinated thiazolidinols cause A549 lung cancer cell death by acting via PI3K/Akt/mTOR and MEK/ERK pathways.
 
Med. Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6MD00012F, Review Article
Interactions between biologically active compounds and their targets often involve hydrophobic interactions, and hydrophobicity also influences the pharmacokinetic profile.
 

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