Based on a 3D-QSAR pharmacophore derived from a diverse set of known cyclin-dependent kinase 9 (CDK9) inhibitors and a composite pharmacophore extracted from the complex structure of flavopiridol (FVP)-CDK9, thirty...
N-Methylation of the N–Cα peptide bond is a known strategy to overcome the liabilities inherently associated with peptide-like molecules. Here, we apply this strategy to transition state mimetics that are...
Novel dinuclear arene ruthenium trithiolato complexes containing a water-soluble peptide moiety in one of the three thiolato bridges were designed and evaluated against A2780 human ovarian cancer cells and against their cisplatin-resistant mutant A2780cisR.
A series of novel derivatives of gambogenic acid (GNA) were synthesized and evaluated for their in vitro antiproliferative activity against four kinds of tumor cell lines. These compounds displayed potent antiproliferative activity. In particular, compound 3f exhibited superior antiproliferative activity against these tumor cell lines than GNA.
The biomedical application of semiconductor quantum dots (QDs) are still limited due to the decrease in their photoluminescence (PL) after surface modification for target specificity and in vivo imaging. This...
The work reports the preparation of antimicrobial spine-bone-cement with a highly controlled release formulation that was subjected to tests, involving in vitro and in vivo biological assessments such as antimicrobial effects, a cytotoxicity test, a bacterial reverse mutation (Ames) assay, a micronucleus assay, and implantation analysis.
Four novel series of quinazoline derivatives IIIa–c, VIa–c and their NO-hybrid molecules as nitrate esters Va–c and VIIIa–c have been synthesized and evaluated for their anti-inflammatory activity in vivo and in vitro.
Compounds 14 and 62 were identified using virtual screening to inhibit autophagy. The expression levels of the LC3-II and p62 autophagy proteins were used. SAR analysis revealed another active compound 38. Formation of autophagosomes was severely reduced upon dosing of 14, 38 and 62.
A D-proline peptidomimetic targeting MMP-2 and MMP-9 was identified from a pool of compounds following enzyme inhibition kinetics and Matrigel sponge assays, showing the capacity of blocking capillary network formation in vivo.
A series of quinazolinone azoles were synthesized and screened for their antimicrobial activities, and further studies of their binding behaviors with calf thymus DNA and human serum albumin were investigated.
Since fungal natural products biosynthesized by polyketide synthases frequently exhibit useful biological activities, identifying and understanding the mechanism of biosynthetic steps taken by PKSs are of great interest.
IM–chitosan complex encapsulated poly(ε-caprolactone) (PCL) nanoparticles are proposed for their potential in enabling more intelligent controlled release and enhancing chemotherapeutic efficiency of IM.