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Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
Impact Factor 3.21 12 Issues per Year Indexed in Medline
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Molecular BioSystems,
01 September 2015 , Issue 9,
Page 2385 to 2598
Robert A. Dromms and Mark P. Styczynski
Mol. BioSyst., 2015, 11, 2394-2405
DOI: 10.1039/C5MB00165J, Method
From themed collection 2015 Hot Articles in Molecular BioSystems
We develop several methods to improve the estimation of metabolite concentrations and accumulation fluxes from noisy time-course data, including use of a sigmoidal impulse function and a resampling-based approach.
Suganthagunthalam Dhakshinamoorthy, Nha-Truc Dinh, Jeffrey Skolnick and Mark P. Styczynski
Mol. BioSyst., 2015, 11, 2406-2416
DOI: 10.1039/C5MB00237K, Paper
We characterize the anti-proliferative activity of menaquinone in a leukemia cell line and use metabolomics to link it to phosphoethanolamine.
Haohua Wang, Zhanjiang Yuan, Peijiang Liu and Tianshou Zhou
Mol. BioSyst., 2015, 11, 2417-2428
DOI: 10.1039/C5MB00391A, Paper
From themed collection 2015 Hot Articles in Molecular BioSystems
While cell-to-cell variability is a phenotypic consequence of gene expression noise, sources of this noise may be complex – apart from intrinsic sources such as the random birth/death of mRNA and stochastic switching between promoter states, there are also extrinsic sources of noise such as cell division where division times are either constant or random.
Raúl González-Domínguez, Tamara García-Barrera, Javier Vitorica and José Luis Gómez-Ariza
Mol. BioSyst., 2015, 11, 2429-2440
DOI: 10.1039/C4MB00747F, Paper
This work describes the first metabolomic investigation of systemic manifestations of Alzheimer's disease in liver and kidney from the APP/PS1 transgenic mouse model.
Mol. BioSyst., 2015, 11, 2441-2448
DOI: 10.1039/C5MB00184F, Paper
The calorimetric analyses demonstrate the RNA- and DNA-binding manner of YB-1 and their specific binding and the assisted affinity enhancement.
Mol. BioSyst., 2015, 11, 2449-2463
DOI: 10.1039/C5MB00122F, Paper
(a) maxPiter-algorithm and (b) maxPincrement-algorithm take only a fraction of existing method's time for different network types.
Mol. BioSyst., 2015, 11, 2464-2472
DOI: 10.1039/C5MB00268K, Paper
An orthogonal type I FAS was introduced into E. coli to increase the production of long chain alcohols and alkanes.
Mol. BioSyst., 2015, 11, 2473-2482
DOI: 10.1039/C5MB00182J, Paper
A visualization method is proposed for transient alteration of bacterial metabolic balance by using correlation network of metabolite abundance.
Margherita Ruoppolo, Emanuela Scolamiero, Marianna Caterino, Valentina Mirisola, Flavia Franconi and Ilaria Campesi
Mol. BioSyst., 2015, 11, 2483-2492
DOI: 10.1039/C5MB00297D, Paper
From themed collection Chemical Biology in Molecular BioSystems
Our data give information on the necessity of different reference ranges of blood metabolites for male and female neonates and the importance of including sex as a variable in future investigations of circulating metabolites.
Muhrez Kienana, Nadal-Desbarats Lydie, Halimi Jean-Michel, Dieme Binta, Büchler Matthias, Emond Patrick, Blasco Hélène and Le Guellec Chantal
Mol. BioSyst., 2015, 11, 2493-2510
DOI: 10.1039/C5MB00108K, Paper
Combined 1H-NMR and GC-MS metabolomics highlight the biochemical pathways that are differentially affected by transplantation over time.
Dafei Xie, Lu Han, Yifu Luo, Yang Liu, Song He, Hui Bai, Shengqi Wang and Xiaochen Bo
Mol. BioSyst., 2015, 11, 2511-2519
DOI: 10.1039/C5MB00309A, Paper
Genome-wide RNA interference screens have greatly facilitated the identification of essential host factors (EHFs) for viral infections, whose knockdown effects significantly influence virus replication but not host cell viability.
E. Sánchez-Guerrero, M. E. Hernández-Campos, J. Correa-Basurto, P. López-Sánchez and L. E. Tolentino-López
Mol. BioSyst., 2015, 11, 2520-2528
DOI: 10.1039/C5MB00342C, Paper
From themed collection Chemical Biology in Molecular BioSystems
The recent finding of a specific receptor for prorrenin/renin (PRR) has brought new insights into the physiology of the renin–angiotensin–aldosterone system.
Lakshmi Dhevi N. Selvan, Sreelakshmi K. Sreenivasamurthy, Satwant Kumar, Soujanya D. Yelamanchi, Anil K. Madugundu, Abhijith K. Anil, Santosh Renuse, Bipin G. Nair, Harsha Gowda, Premendu P. Mathur, Parthasarathy Satishchandra, S. K. Shankar, Anita Mahadevan and T. S. Keshava Prasad
Mol. BioSyst., 2015, 11, 2529-2540
DOI: 10.1039/C5MB00187K, Paper
Brain proteome profile of cryptococcal meningitis co-infected with HIV.
Mol. BioSyst., 2015, 11, 2541-2550
DOI: 10.1039/C5MB00276A, Paper
Several new candidate carcinogenic/non-carcinogenic chemicals obtained by our method exhibit structural dissimilarity with validated carcinogenic/non-carcinogenic chemicals.
Santi M. Mandal, Anirban Chakraborty, Maidul Hossain, Denial Mahata, William F. Porto, Ranadhir Chakraborty, Chinmay K. Mukhopadhyay, Octavio L. Franco, Tapas K. Hazra and Amit Basak
Mol. BioSyst., 2015, 11, 2551-2559
DOI: 10.1039/C5MB00366K, Paper
Amphotericin B and anidulafungin are widely used antifungal drugs for the treatment of systemic and serious mycoses.
Mol. BioSyst., 2015, 11, 2560-2567
DOI: 10.1039/C5MB00340G, Paper
Metabolic suppression has been revealed during mesodermal differentiation by using single-cell gene expression analysis.
Mol. BioSyst., 2015, 11, 2568-2578
DOI: 10.1039/C5MB00394F, Paper
Mutations at a number of key positions (Ala156, Asp168 and Arg155) of the HCV NS3/4A protease can induce medium to high resistance to MK5172.
Huy Tran, Samuel M. D. Oliveira, Nadia Goncalves and Andre S. Ribeiro
Mol. BioSyst., 2015, 11, 2579-2587
DOI: 10.1039/C5MB00244C, Paper
Characterization of the cellular intake kinetics of a lactose analogue from in vivo single-event measurements of transcription activity.
L. Xiang, W. S. Cheang, S. H. Lin, L. Wang, Y. L. Li, Y. Huang and Z. W. Cai
Mol. BioSyst., 2015, 11, 2588-2596
DOI: 10.1039/C5MB00363F, Paper
Regulatory effect of moderate exercise training on fatty acid oxidation.

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