Journal cover: Molecular BioSystems

Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.
Impact Factor 3.183 12 Issues per Year Indexed in MEDLINE
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Molecular BioSystems,
01 November 2014 , Issue 11,
Page 2737 to 3032
Mol. BioSyst., 2014, 10, 2748-2755
DOI: 10.1039/C4MB00119B, Review Article
The main physiological challenge in high-altitude plateau environments is hypoxia.
Mol. BioSyst., 2014, 10, 2756-2774
DOI: 10.1039/C4MB00233D, Review Article
We review fluorescence emission properties of 8-azapurines and related compounds, and their potential as fluorescence probes in various biochemical systems.
Lian Duan, Xingjiang Xiong, Yongmei Liu and Jie Wang
Mol. BioSyst., 2014, 10, 2775-2782
DOI: 10.1039/C4MB00338A, Review Article
microRNAs (miRNAs) are a class of small non-coding RNA molecules consisting of 19–22 nucleotides that play an important role in a variety of biological processes, including development, differentiation, apoptosis, cell proliferation and cellular senescence.
Peng Zhan, Yu'ning Song, Yukihiro Itoh, Takayoshi Suzuki and Xinyong Liu
Mol. BioSyst., 2014, 10, 2783-2799
DOI: 10.1039/C4MB00385C, Review Article
Medicinal chemistry strategies employed in the discovery of TNKSIs.
Mol. BioSyst., 2014, 10, 2800-2809
DOI: 10.1039/C4MB00353E, Method
Prioritization of candidate disease miRNAs by integrating phenotype associations of multiple diseases with matched miRNA and mRNA expression profiles.
Irina V. Nesterova, Siddieg O. Elsiddieg and Evgueni E. Nesterov
Mol. BioSyst., 2014, 10, 2810-2814
DOI: 10.1039/C4MB00363B, Communication
A simple single stranded DNA-based molecular switch processes two physiologically relevant inputs: pH (i.e. environment alkalinisation) and enzymatic activity, and generates a chemical output (in situ synthesized oligonucleotide).
D. Pozzi, G. Caracciolo, A. L. Capriotti, C. Cavaliere, S. Piovesana, V. Colapicchioni, S. Palchetti, A. Riccioli and A. Laganà
Mol. BioSyst., 2014, 10, 2815-2819
DOI: 10.1039/C4MB00292J, Communication
Here we introduce a proteomics methodology based on nanoliquid-chromatography tandem mass spectrometry (nanoLC/MS-MS) to investigate the “protein corona effect for targeted drug delivery”.
Volker Behrends, Ram P. Maharjan, Ben Ryall, Lu Feng, Bin Liu, Lei Wang, Jacob G. Bundy and Thomas Ferenci
Mol. BioSyst., 2014, 10, 2820-2822
DOI: 10.1039/C4MB00313F, Communication
Using full genome sequencing and metabolomics we show that adaptation to chronic nutrient starvation reduces metabolic flexibility in Escherichia coli.
Mol. BioSyst., 2014, 10, 2823-2826
DOI: 10.1039/C4MB00366G, Communication
Globin coupled sensors exist as a mixture of oligomeric states, which affect both enzyme catalysis and oxygen binding.
Mol. BioSyst., 2014, 10, 2827-2837
DOI: 10.1039/C4MB00250D, Paper
UPLC-IM-MS/MS analysis of human breast tissue extracts distinguished cancerous and non-cancerous breast diseases by characteristic molecular signatures.
Joaquim V. Marques, Doralyn S. Dalisay, Hong Yang, Choonseok Lee, Laurence B. Davin and Norman G. Lewis
Mol. BioSyst., 2014, 10, 2838-2849
DOI: 10.1039/C4MB00403E, Paper
Advanced metabolomics/metabolite imaging in situ, transcriptome sequencing, and bioinformatics enabled discovery and localization of a previously undetectable biochemical pathway to aporphine alkaloids in Podophyllum hexandrum/peltatum. This discovery settles a century old enigma.
Konstantine Tchourine, Christopher S. Poultney, Li Wang, Gustavo M. Silva, Sandhya Manohar, Christian L. Mueller, Richard Bonneau and Christine Vogel
Mol. BioSyst., 2014, 10, 2850-2862
DOI: 10.1039/C4MB00358F, Paper
From themed collection 2014 Emerging Investigators
A simple rate equation predicts time-resolved expression for 1/3 of the tested genes and suggest two mutually exclusive modes of regulation.
Mol. BioSyst., 2014, 10, 2863-2869
DOI: 10.1039/C4MB00396A, Paper
We explored the binding modes of fluoroquinolone in the HERG potassium channel by using molecular docking and molecular dynamics simulation approaches.
Mol. BioSyst., 2014, 10, 2870-2875
DOI: 10.1039/C4MB00325J, Paper
Identifying module biomarkers for multi-phenotypes from high-throughput data by integer linear programming.
Jaymin J. Kathiriya, Ravi Ramesh Pathak, Eric Clayman, Bin Xue, Vladimir N. Uversky and Vrushank Davé
Mol. BioSyst., 2014, 10, 2876-2888
DOI: 10.1039/C4MB00224E, Paper
We reveal presence of intrinsically disordered regions in human kinome and build a kinase–kinase interaction network identifying a novel SRC–SMAD relationship.
Tracy R. McKnight, Hikari A. I. Yoshihara, Lungile J. Sitole, Jeffery N. Martin, Francois Steffens and Debra Meyer
Mol. BioSyst., 2014, 10, 2889-2897
DOI: 10.1039/C4MB00347K, Paper
Combined chemometric and quantitative analysis of NMR spectra from HIV-infected sera disclosed previously unknown associations between specific metabolites, such as alanine, and disease status.
Mol. BioSyst., 2014, 10, 2898-2906
DOI: 10.1039/C4MB00278D, Paper
A plasma metabonomic approach was applied to investigate the effects of P. discolor and corosolic acid.
Mol. BioSyst., 2014, 10, 2907-2913
DOI: 10.1039/C4MB00199K, Paper
Predicting new drug–pathway interactions from heterogeneous biological data is important not only for the understanding of various drug response and molecular interaction processes, but also for the development of novel drugs and the therapy of human diseases.
Limiao Jiang, Xiuju Zhao, Chongyang Huang, Hehua Lei, Huiru Tang and Yulan Wang
Mol. BioSyst., 2014, 10, 2914-2922
DOI: 10.1039/C4MB00218K, Paper
We characterized dose- and time-dependent metabolic alterations in rats subchronically exposed to mequindox through dietary supplementation, employing NMR based metabonomics.
Dan-Dan Wei, Ge-Dong, Ping-Ping Guo, Jun-Song Wang, Ming-Hui Li, Ming-Hua Yang and Ling-Yi Kong
Mol. BioSyst., 2014, 10, 2923-2934
DOI: 10.1039/C4MB00279B, Paper
A systematic approach based on the 1H NMR metabolomic technique was performed to explore metabolic alterations in brain after anisatin intoxication.
Mol. BioSyst., 2014, 10, 2935-2941
DOI: 10.1039/C4MB00354C, Paper
Transcription control insights using blood ChIP sequencing compendium.
Jitendra Maharana, Bikash Ranjan Sahoo, Aritra Bej, Mahesh Chandra Patra, Budheswar Dehury, Gopal Krushna Bhoi, Santosh Kumar Lenka, Jyoti Ranjan Sahoo, Ajaya Kumar Rout and Bijay Kumar Behera
Mol. BioSyst., 2014, 10, 2942-2953
DOI: 10.1039/C4MB00212A, Paper
This study represents the molecular mechanism of iE-DAP recognition in zNOD1-LRR. The key residues involved in recognition of iE-DAP perfectly correlate with experimental findings in human with few exceptions.
Mol. BioSyst., 2014, 10, 2954-2964
DOI: 10.1039/C4MB00306C, Paper
5-Fluoro-2′-deoxyuridine, an analog of 5-fluorouracil, has high binding affinity and thermal stability toward the N-isoform compared to the B-isoform of HSA.
Mol. BioSyst., 2014, 10, 2965-2973
DOI: 10.1039/C4MB00301B, Paper
This is the first report revealing the metabolic characteristics of lumbar disc herniation and its traditional Chinese medicine subtypes via GC-MS metabonomic analysis.
Raphaël Bilgraer, Sylvie Gillet, Sophie Gil, Danièle Evain-Brion and Olivier Laprévote
Mol. BioSyst., 2014, 10, 2974-2983
DOI: 10.1039/C4MB00395K, Paper
We have developed a new global histonomic approach for deciphering histone code disruption in human cells after xenobiotic exposure.

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