Journal cover: Molecular BioSystems

Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.
Impact Factor 3.183 12 Issues per Year Indexed in MEDLINE
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Molecular BioSystems,
01 October 2014 , Issue 10,
Page 2485 to 2736
Renxiang Yan, Xiaofeng Wang, Lanqing Huang, Jun Lin, Weiwen Cai and Ziding Zhang
Mol. BioSyst., 2014, 10, 2495-2504
DOI: 10.1039/C4MB00272E, Method
G protein coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, pass through the cellular membrane seven times and play diverse biological roles in the cells such as signaling, transporting of molecules and cell–cell communication.
Mol. BioSyst., 2014, 10, 2505-2508
DOI: 10.1039/C4MB00351A, Communication
A HIF-1 protein–protein interaction inhibitor is used to establish the presence of a HIF-1α transactivation loop in hypoxia.
Mol. BioSyst., 2014, 10, 2509-2516
DOI: 10.1039/C4MB00220B, Paper
The molecular recognition of amphenicols by low-molecular-weight proteins may have great impact on the pharmacokinetics of amphenicols in the human body.
Xinzhuang Zhang, Jiangyong Gu, Liang Cao, Na Li, Yiming Ma, Zhenzhen Su, Gang Ding, Lirong Chen, Xiaojie Xu and Wei Xiao
Mol. BioSyst., 2014, 10, 2517-2525
DOI: 10.1039/C4MB00164H, Paper
The mechanism of RDN on URTIs is to inhibit virus–host interaction and to regulate signaling pathways by a combination of multi-target ingredients.
Mol. BioSyst., 2014, 10, 2526-2537
DOI: 10.1039/C4MB00115J, Paper
We developed a metabolic network model that maps hourly gene expression to time-dependent metabolism and stage-specific growth, allowing us to link specific metabolites or pathways to specific physiological functions.
Romanas Chaleckis, Masahiro Ebe, Tomáš Pluskal, Itsuo Murakami, Hiroshi Kondoh and Mitsuhiro Yanagida
Mol. BioSyst., 2014, 10, 2538-2551
DOI: 10.1039/C4MB00346B, Paper
Comparison of human blood and fission yeast metabolomes revealed that 75% of compounds found in human blood are also detected in fission yeast. Several methylated amino acids are reported as new blood components.
Mol. BioSyst., 2014, 10, 2552-2557
DOI: 10.1039/C4MB00304G, Paper
The interaction of Ru1 with the triplex RNA poly(U)·poly(A)*poly(U) has been studied by various biophysical techniques. The results obtained here indicate that Ru1 may act as a sensitive luminescent probe for poly(U)·poly(A)*poly(U) in solution and can obviously stabilize the Hoogsteen base-paired third strand of the triplex.
Jing Yu, Le Feng, Yan Wu, Hao Wang, Jun Ba, Wei Zhu and Chunlei Xie
Mol. BioSyst., 2014, 10, 2558-2566
DOI: 10.1039/C4MB00240G, Paper
To understand the molecular mechanisms of idiopathic epiretinal membranes (iERMs), the vitreous proteomes of patients with iERMs were investigated.
Mol. BioSyst., 2014, 10, 2567-2577
DOI: 10.1039/C4MB00138A, Paper
Epidermolysis bullosa simplex (EBS) is a genodermatosis caused by mutations in keratins 5 and 14 (K5 and K14), which leads to fragility of basal keratinocytes and eventually epidermal cytolysis and blistering.
Mol. BioSyst., 2014, 10, 2578-2589
DOI: 10.1039/C4MB00181H, Paper
Different environmental conditions lead to different metabolic flows, leading to changes in epistasis interactions between genes. Epistasis in turn affects the adaptive fitness landscape.
Alexandra A. Kulikova, Philipp O. Tsvetkov, Maria I. Indeykina, Igor A. Popov, Sergey S. Zhokhov, Andrey V. Golovin, Vladimir I. Polshakov, Sergey A. Kozin, Evgeny Nudler and Alexander A. Makarov
Mol. BioSyst., 2014, 10, 2590-2596
DOI: 10.1039/C4MB00332B, Paper
Phosphorylation of Ser8 leads to the formation of a new Zn2+ binding site and promotes zinc-induced dimerization of Aβ(1–16).
Mol. BioSyst., 2014, 10, 2597-2606
DOI: 10.1039/C4MB00322E, Paper
S-Nitrosylated cysteine, surrounding by basic residues, is of lower pKa, less steric hindrance, and relatively higher flexibility.
Mol. BioSyst., 2014, 10, 2607-2616
DOI: 10.1039/C4MB00320A, Paper
Excess copper is toxic to organisms, and therefore, copper homeostasis is important for the limitation of its cellular levels.
Mol. BioSyst., 2014, 10, 2617-2625
DOI: 10.1039/C4MB00131A, Paper
24 potential biomarkers contacted with adjuvant-induced arthritis have been identified by UPLC-MS and tryptophan metabolism, phenylalanine metabolism, gut microbiota metabolism and energy metabolism were disturbed.
Bora Uyar, Robert J. Weatheritt, Holger Dinkel, Norman E. Davey and Toby J. Gibson
Mol. BioSyst., 2014, 10, 2626-2642
DOI: 10.1039/C4MB00290C, Paper
Mutations in short linear motifs impair the functions of intrinsically disordered proteins in cellular signaling/regulation and contribute substantially to human diseases.
Yan Zeng, Lei Qi, Sifan Li, Yurong Hou, Wei Xu, Hong Wang, Xiujuan Zhao and Changhao Sun
Mol. BioSyst., 2014, 10, 2643-2653
DOI: 10.1039/C4MB00299G, Paper
A previous study of ours has reported that chronic exposure to low-level dichlorvos (DDVP, 7.2 mg per kg bw) damages the liver, interferes with fatty acid metabolism, and disturbs the antioxidant defense system in rats.
Mehran Aflakparast, Ali Masoudi-Nejad, Joseph H . Bozorgmehr and Shyam Visweswaran
Mol. BioSyst., 2014, 10, 2654-2662
DOI: 10.1039/C4MB00123K, Paper
In high-dimensional genome-wide (GWA) data, a key challenge is to detect genomic variants that interact in a nonlinear fashion in their association with disease.
Sarah Schatschneider, Claudia Huber, Heiko Neuweger, Tony Francis Watt, Alfred Pühler, Wolfgang Eisenreich, Christoph Wittmann, Karsten Niehaus and Frank-Jörg Vorhölter
Mol. BioSyst., 2014, 10, 2663-2676
DOI: 10.1039/C4MB00198B, Paper
Complex metabolic flux pattern of X. campestris.
Nusrat J. M. Sanghamitra, Hiroshi Inaba, Fumio Arisaka, Dan Ohtan Wang, Shuji Kanamaru, Susumu Kitagawa and Takafumi Ueno
Mol. BioSyst., 2014, 10, 2677-2683
DOI: 10.1039/C4MB00293H, Paper
We demonstrated that a bacteriophage T4 derived protein needle based on a triple-stranded β-helix motif translocates through the living cell membrane.
Mol. BioSyst., 2014, 10, 2684-2692
DOI: 10.1039/C4MB00307A, Paper
We have designed an ensemble docking-based hybrid QSAR encompassing receptor flexibility to screen novel BACE1 inhibitory phytochemicals.
Mol. BioSyst., 2014, 10, 2693-2698
DOI: 10.1039/C4MB00364K, Paper
Phosphorylation of the regulatory light chain of smooth muscle myosin produces a unique structural balance needed for muscle activation.
Palani Kirubakaran, Pitchaimani Arunkumar, Kumpati Premkumar and Karthikeyan Muthusamy
Mol. BioSyst., 2014, 10, 2699-2712
DOI: 10.1039/C4MB00309H, Paper
Sighting of tankyrase inhibitors by structure- and ligand-based screening and in vitro approach.
Mol. BioSyst., 2014, 10, 2713-2723
DOI: 10.1039/C4MB00155A, Paper
We describe a novel approach to screen for growth promoting compounds and score putative targets using a drug–protein interaction database.
Mol. BioSyst., 2014, 10, 2724-2734
DOI: 10.1039/C4MB00359D, Paper
Diminazene or berenil is known to be an AT-rich DNA minor groove binder with micromolar dissociation constant. Here, we show that DMZ binds to G-quadruplexes with Kd as low as 1 nM.

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