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Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
Impact Factor 2.829 12 Issues per Year Indexed in Medline
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Molecular BioSystems,
01 October 2016 , Issue 10,
Page 2943 to 3236
Mol. BioSyst., 2016, 12, 2953-2964
DOI: 10.1039/C6MB00476H, Review Article
From themed collection 2016 Hot Articles in Molecular BioSystems
Biomolecular networks, such as genome-scale metabolic models and protein–protein interaction networks, facilitate the extraction of new information from high-throughput omics data.
Ahmet F. Coskun, Umut Eser and Saiful Islam
Mol. BioSyst., 2016, 12, 2965-2979
DOI: 10.1039/C6MB00388E, Review Article
From themed collection 2016 Hot Articles in Molecular BioSystems
Single cell molecular profiling techniques decode cellular identity formation within developing complex tissues and organs in both health and disease.
Mol. BioSyst., 2016, 12, 2980-2983
DOI: 10.1039/C6MB00414H, Communication
Computer simulation reveals that the origin of SET8 catalytic power is mainly due to electrostatic preorganization.
Mol. BioSyst., 2016, 12, 2984-2987
DOI: 10.1039/C6MB00454G, Communication
Cell-based assays for amylin and huntingtin solubility, capable of reporting on the influence of mutations and small molecules, are reported.
Shourjya Sanyal, David F. Coker and Donal MacKernan
Mol. BioSyst., 2016, 12, 2988-2991
DOI: 10.1039/C6MB00410E, Communication
A simple numerical procedure to measure the flexibility of linker proteins used in unimolecular FRET probes.
Mol. BioSyst., 2016, 12, 2992-3004
DOI: 10.1039/C6MB00373G, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Cytochrome P450 StaH catalyses the first cyclisation reaction in the biosynthesis of the glycopeptide antibiotic A47934 via recruitment to the NRPS machinery through interaction with the X-domain.
Viktoria M. Enk, Christian Baumann, Michaela Thoß, Kenneth C. Luzynski, Ebrahim Razzazi-Fazeli and Dustin J. Penn
Mol. BioSyst., 2016, 12, 3005-3016
DOI: 10.1039/C6MB00278A, Paper
From themed collection Omics in Animal Sciences
We performed isoform-specific MUP quantification on MS1 and MS2 level in response to increased social interaction of male wild house mice by seminatural housing.
Panchanand Mishra, Suresh Satpati, Sudhira Kumar Baral, Anshuman Dixit and Surendra Chandra Sabat
Mol. BioSyst., 2016, 12, 3017-3031
DOI: 10.1039/C6MB00458J, Paper
Superoxide dismutase (SOD) is a unique homo-dimeric enzyme that can scavenge toxic superoxide radicals by dismutation reaction. This study analysed the role of Cys in modulating the stability and kinetic properties of IcSOD.
Xin Li, Kirsten Heimann, Xuyen Thi Dinh, F. Richard Keene and J. Grant Collins
Mol. BioSyst., 2016, 12, 3032-3045
DOI: 10.1039/C6MB00431H, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
The biological processing, including the effect on the cytoplasmic membrane, of dinuclear polypyridylruthenium(II) complexes has been examined in eukaryotic cells.
Kazuhide Sato, Alexander P. Gorka, Tadanobu Nagaya, Megan S. Michie, Yuko Nakamura, Roger R. Nani, Vince L. Coble, Olga V. Vasalatiy, Rolf E. Swenson, Peter L. Choyke, Martin J. Schnermann and Hisataka Kobayashi
Mol. BioSyst., 2016, 12, 3046-3056
DOI: 10.1039/C6MB00371K, Paper
Small changes on cyanine dyes to the chemical structure can alter in vivo pharmacokinetics of mAb–dye conjugates.
Lixin Cheng, Xuan Wang, Pak-Kan Wong, Kwan-Yeung Lee, Le Li, Bin Xu, Dong Wang and Kwong-Sak Leung
Mol. BioSyst., 2016, 12, 3057-3066
DOI: 10.1039/C6MB00386A, Paper
The global increase of gene expression has been frequently established in cancer microarray studies.
David Xu, Shadia I. Jalal, George W. Sledge and Samy O. Meroueh
Mol. BioSyst., 2016, 12, 3067-3087
DOI: 10.1039/C6MB00231E, Paper
The Cancer Genome Atlas (TCGA) offers an unprecedented opportunity to identify small-molecule binding sites on proteins with overexpressed mRNA levels that correlate with poor survival.
Mol. BioSyst., 2016, 12, 3088-3097
DOI: 10.1039/C6MB00284F, Paper
From themed collection Chemical Biology in Molecular BioSystems
PQ–MB may affect the behavior and cognitive function of rat offspring through the cAMP–PKA–CREB signaling pathway.
Mol. BioSyst., 2016, 12, 3098-3110
DOI: 10.1039/C6MB00276E, Paper
The generalized asynchronous Boolean network model proposed in this paper can reliably mimic the temporal behavior of the Ordinary Differential Equation model without compromising the flexibility of the Boolean network model.
Mol. BioSyst., 2016, 12, 3111-3123
DOI: 10.1039/C6MB00306K, Paper
Binding of DNA methyltransferase M. Hpy C5mC, to cofactor AdoMet and substrate DNA revealed from MD simulations.
Mol. BioSyst., 2016, 12, 3124-3131
DOI: 10.1039/C6MB00295A, Paper
We developed a promising SVM-based program, plantMirP, for predicting plant pre-miRNAs by incorporating a set of novel knowledge-based energy features.
Federica del Gaudio, Carmen Festa, Matteo Mozzicafreddo, Michele Vasaturo, Agostino Casapullo, Simona De Marino, Raffaele Riccio and Maria Chiara Monti
Mol. BioSyst., 2016, 12, 3132-3138
DOI: 10.1039/C6MB00460A, Paper
Extracts of Ruscus aculeatus are rich of deglucoruscin, a spirostanol glycoside, which is able to interact with ATP synthase and modulate its activity.
Mol. BioSyst., 2016, 12, 3139-3145
DOI: 10.1039/C6MB00537C, Paper
A single Tyr introduced in the secondary sphere of the heme active site in myoglobin at position 107 or 138 forms a distinct Tyr-associated H-bond network, regulating both the protein properties and functions.
Mol. BioSyst., 2016, 12, 3146-3165
DOI: 10.1039/C6MB00298F, Paper
The computational analysis of residue interaction networks dissects the allosteric effects of inhibitor-induced BRAF kinase dimerization and paradoxical activation.
Yassir A. Ahmed, Edwin A. Yates, Diana J. Moss, Markus A. Loeven, Sadaf-Ahmahni Hussain, Erhard Hohenester, Jeremy E. Turnbull and Andrew K. Powell
Mol. BioSyst., 2016, 12, 3166-3175
DOI: 10.1039/C6MB00432F, Paper
Panels of heparin/heparan sulfate carbohydrates differ in their interactions and bioactivity with Slit and Robo.
Yongjing Liu, Rui Zhang, Ning Zhao, Qiang Zhang, Zichuang Yan, Zhiqiang Chang, Yunzhen Wei, Cheng Wu, Jin Xu and Yan Xu
Mol. BioSyst., 2016, 12, 3176-3185
DOI: 10.1039/C6MB00359A, Paper
Although the key roles of long non-coding RNAs (lncRNAs) in multiple diseases are well documented, the relationship between the lncRNA copy number and expression is unknown.
Mol. BioSyst., 2016, 12, 3186-3195
DOI: 10.1039/C6MB00479B, Paper
It was shown that blood antibodies undergo extensive post-transcriptional half-molecule exchange by HL-fragments. Human blood IgGs contain 8.8 ± 2.7% (range 2.6–14%) chimeric kappa-lambda IgGs, which consist of IgG1–IgG4.
Nitesh Kumar Singh, Mathias Ernst, Volkmar Liebscher, Georg Fuellen and Leila Taher
Mol. BioSyst., 2016, 12, 3196-3208
DOI: 10.1039/C6MB00280C, Paper
We present an approach that integrates gene expression and biological annotation data to identify and describe the interactions between biological functions, processes and pathways that govern a phenotype of interest.
Mol. BioSyst., 2016, 12, 3209-3222
DOI: 10.1039/C6MB00469E, Paper
Terminal regions in SELK present different conformational dynamics being coupled complicatedly through the membrane.
Mol. BioSyst., 2016, 12, 3223-3233
DOI: 10.1039/C6MB00342G, Paper
The development of fatal transmissible spongiform encephalopathies (TSE) is associated with the conformational conversion of the normal cellular prion protein, PrPC, into its pathogenic isoform, PrPSc.

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43 citations
With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent to develop automated methods for analyzing the relationship between the sequences and their functions.
DOI: 10.1039/C5MB00155B
Published: 05 Jun 2015
12 citations
Immunoglobulins, also called antibodies, are a group of cell surface proteins which are produced by the immune system in response to the presence of a foreign substance (called antigen).
DOI: 10.1039/C5MB00883B
Published: 11 Feb 2016
39 citations
Mechanistic insight into the BSA–limonene interaction: biophysical and molecular docking approach.
DOI: 10.1039/C4MB00548A
Published: 23 Oct 2014

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