Journal cover: Molecular BioSystems

Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.
Impact Factor 3.183 12 Issues per Year Indexed in MEDLINE
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Molecular BioSystems,
01 December 2014 , Issue 12,
Page 3033 to 3324
Sabine Hummert, Katrin Bohl, David Basanta, Andreas Deutsch, Sarah Werner, Günter Theißen, Anja Schroeter and Stefan Schuster
Mol. BioSyst., 2014, 10, 3044-3065
DOI: 10.1039/C3MB70602H, Review Article
The interaction of living cells can often be described by game theory, for example, in the case of secretion of extracellular enzymes. In this review we discuss numerous examples of applying game theory to cellular processes.
Katrin Bohl, Sabine Hummert, Sarah Werner, David Basanta, Andreas Deutsch, Stefan Schuster, Günter Theißen and Anja Schroeter
Mol. BioSyst., 2014, 10, 3066-3074
DOI: 10.1039/C3MB70601J, Review Article
In many situations macromolecules, such as proteins, DNA and RNA, can be considered as players in the sense of game theory. In this review we discuss the usefulness of game theory in describing macromolecular processes.
Xiuqin Liu, Jun Ding and Fuzhou Gong
Mol. BioSyst., 2014, 10, 3075-3080
DOI: 10.1039/C4MB00447G, Method
Piwi-interacting RNA (piRNA) is a class of small non-coding RNAs about 24 to 32 nucleotides long, associated with PIWI proteins, which are involved in germline development, transposon silencing, and epigenetic regulation.
Ting-Ting Chu, Qian-Qian Li, Tian Qiu, Zhan-Yi Sun, Zhi-Wen Hu, Yong-Xiang Chen, Yu-Fen Zhao and Yan-Mei Li
Mol. BioSyst., 2014, 10, 3081-3085
DOI: 10.1039/C4MB00508B, Communication
An artificial ‘hydrolase’ cleaves intracellular tau.
Hui-Ju Huang, Chi-Chen Lin, Hsiu-Chuan Chou, Yi-Wen Chen, Szu-Ting Lin, Yi-Chieh Lin, Dai-Ying Lin, Kevin W. Lyu and Hong-Lin Chan
Mol. BioSyst., 2014, 10, 3086-3100
DOI: 10.1039/C4MB00451E, Paper
Rhein promotes misfolding of cellular proteins as well as unbalancing of the cellular redox status leading to ER-stress.
Daniel Pushparaju Yeggoni and Rajagopal Subramanyam
Mol. BioSyst., 2014, 10, 3101-3110
DOI: 10.1039/C4MB00408F, Paper
L-Dopa has been used to increase dopamine concentrations in the treatment of Parkinson's disease and dopamine-responsive dystonia.
Mol. BioSyst., 2014, 10, 3111-3119
DOI: 10.1039/C4MB00464G, Paper
In this study, we aimed to find a signature that can detect chemoresistance to taxane-based therapies in breast cancer.
Mol. BioSyst., 2014, 10, 3120-3129
DOI: 10.1039/C4MB00371C, Paper
Dynamical behavior of Gal80p in the presence of Gal3p and Gal1p.
Zhonghua Wang, Yuki Ando, Ari Dwi Nugraheni, Chunguang Ren, Satoshi Nagao and Shun Hirota
Mol. BioSyst., 2014, 10, 3130-3137
DOI: 10.1039/C4MB00285G, Paper
Met80 of cyt c is oxidized site-specifically by reaction of heme with molecular oxygen in the presence of a reducing agent, when Met80 dissociates from the heme iron due to interaction of the protein with cardiolipin.
Mol. BioSyst., 2014, 10, 3138-3146
DOI: 10.1039/C4MB00386A, Paper
A genome-wide c-type cytochrome network was constructed to explore the extracellular electron transfer pathways in Shewanella oneidensis MR-1.
Mol. BioSyst., 2014, 10, 3147-3154
DOI: 10.1039/C4MB00410H, Paper
We developed a novel method to predict human–HCV protein–protein interactions, the most comprehensive study of this type.
Mol. BioSyst., 2014, 10, 3155-3162
DOI: 10.1039/C4MB00420E, Paper
Qualitatively different membranotropic effects of the individual drugs and complexes formed in their combined use were demonstrated by differential scanning calorimetry.
Wen-Ling Chen, Ching-Yu Lin, Yuan-Horng Yan, Karen T. Cheng and Tsun-Jen Cheng
Mol. BioSyst., 2014, 10, 3163-3169
DOI: 10.1039/C4MB00435C, Paper
Long-term and low-concentration exposure to ambient PM2.5 alters the pulmonary phosphatidylcholine profile which conforms to histopathological changes in the lung.
Yongxia Yang, Ying Liu, Lingyun Zheng, Teng Wu, Jiangchao Li, Qianqian Zhang, Xiaoqiang Li, Fengying Yuan, Lijing Wang and Jiao Guo
Mol. BioSyst., 2014, 10, 3170-3178
DOI: 10.1039/C4MB00334A, Paper
The 1H NMR-based analysis of the apoE−/− serum metabonome exhibited a time-dependent metabolic progression for atherosclerosis from the physiological to pathophysiological status.
Dustin A. Wride, Nader Pourmand, Walter M. Bray, Jacob J. Kosarchuk, Sean C. Nisam, Tiffani K. Quan, Ray F. Berkeley, Sol Katzman, Grant A. Hartzog, Carlos E. Dobkin and R. Scott Lokey
Mol. BioSyst., 2014, 10, 3179-3187
DOI: 10.1039/C4MB00146J, Paper
Demonstrating the use of next generation sequencing (NGS) to identify mutations that confer resistance to benomyl and rapamycin, and a method for mapping these mutations to their known biological targets.
Mol. BioSyst., 2014, 10, 3188-3198
DOI: 10.1039/C4MB00323C, Paper
The nociceptin receptor (NOPR) is an orphan G protein-coupled receptor that contains seven transmembrane helices.
Mihoko Ui, Kousuke Harima, Toshiaki Takei, Kouhei Tsumoto, Kazuhito V. Tabata, Hiroyuki Noji, Sumire Endo, Kimio Akiyama, Takahiro Muraoka and Kazushi Kinbara
Mol. BioSyst., 2014, 10, 3199-3206
DOI: 10.1039/C4MB00405A, Paper
We demonstrated that staphylococcal α-hemolysin restored the hemolytic activity with chemically-synthesized prosthetic stem domains.
Aleksandra Maršavelski, Sonja Lesjak, Marko Močibob, Ivana Weygand-Đurašević and Sanja Tomić
Mol. BioSyst., 2014, 10, 3207-3216
DOI: 10.1039/C4MB00416G, Paper
Recently described and characterized Bradyrhizobium japonicum glycine:[carrier protein] ligase 1 (Bj Gly:CP ligase 1), a homologue of methanogenic type seryl-tRNA synthetase (SerRS) is an intriguing enzyme whose physiological role is not yet known.
Sampo Kukkurainen, Juha A. Määttä, John Saeger, Jarkko Valjakka, Viola Vogel and Vesa P. Hytönen
Mol. BioSyst., 2014, 10, 3217-3228
DOI: 10.1039/C4MB00341A, Paper
Interactions and force resistance of different β-integrin–talin complexes were analysed in a set of steered molecular dynamics simulations.
Nidhi Rani, Saravanan Vijayakumar, Lakshmi Palanisamy Thanga Velan and Annamalai Arunachalam
Mol. BioSyst., 2014, 10, 3229-3237
DOI: 10.1039/C4MB00319E, Paper
Computational study on inhibiting MRSA PBP2a revealed quercetin 3-O-rutinoside to be efective among quercetin derivatives. The findings were validated using in vitro studies, which suggested that quercetin 3-O-rutinoside could be used against MRSA.
Mol. BioSyst., 2014, 10, 3238-3248
DOI: 10.1039/C4MB00526K, Paper
Simulation and network analyses revealed that reinforcing feedback loops while significantly depleted but not completely absent in a biological network can trigger a toggle switch between transcriptional programs.
Jin Gu, Yang Chen, Huiya Huang, Lingyun Yin, Zhen Xie and Michael Q. Zhang
Mol. BioSyst., 2014, 10, 3249-3254
DOI: 10.1039/C4MB00329B, Paper
The gene module based approach found that miR-139 can inhibit cancer cell proliferation by directly targeting ETS1.
Manish Kumar Tiwari, Vipin C. Kalia, Yun Chan Kang and Jung-Kul Lee
Mol. BioSyst., 2014, 10, 3255-3263
DOI: 10.1039/C4MB00459K, Paper
This study examined the role of remote residues on the structure and function of zinc-dependent polyol dehydrogenases.
Mol. BioSyst., 2014, 10, 3264-3271
DOI: 10.1039/C4MB00339J, Paper
The complex traits of an organism are associated with a complex interplay between genetic factors (GFs) and environmental factors (EFs).
Mol. BioSyst., 2014, 10, 3272-3279
DOI: 10.1039/C4MB00469H, Paper
MD simulations revealed reversibility of the long range conformational changes of the HCV RNA subdomain IIa.

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