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Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.
Impact Factor 3.183 12 Issues per Year Indexed in MEDLINE
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Molecular BioSystems,
01 April 2015 , Issue 4,
Page 971 to 1206
Gunjan S. Thakur, Bernie J. Daigle Jr, Kelsey R. Dean, Yuanyang Zhang, Maria Rodriguez-Fernandez, Rasha Hammamieh, Ruoting Yang, Marti Jett, Joseph Palma, Linda R. Petzold and Francis J. Doyle III
Mol. BioSyst., 2015, 11, 980-993
DOI: 10.1039/C4MB00404C, Review Article
This review paper presents known biological facts about PTSD and the mathematical/systems biology tools used to understand the underpinning molecular principles.
Fernando J. Alvarez-Vasquez, Julio A. Freyre-González, Yalbi I. Balderas-Martínez, Mónica I. Delgado-Carrillo and Julio Collado-Vides
Mol. BioSyst., 2015, 11, 994-1003
DOI: 10.1039/C4MB00561A, Paper
Transcription factors can bind to DNA either with their effector bound (holo conformation), or as free proteins (apo conformation).
Bin Yang, Bin Liu, Pinduan Bi, Tao Wu, Qiang Wang and Jie Zhang
Mol. BioSyst., 2015, 11, 1004-1011
DOI: 10.1039/C4MB00741G, Paper
An integrated analysis of differential miRNA and mRNA expressions firstly revealed that miR-210 and its target ATP11A may involve in the ABC-transporters pathway, which contribute to gallstone formation.
Igor F. Tsigelny, Valentina L. Kouznetsova, Pengfei Jiang, Sandeep C. Pingle and Santosh Kesari
Mol. BioSyst., 2015, 11, 1012-1028
DOI: 10.1039/C5MB00007F, Paper
We report an integrative networks-based analysis to identify a system of coherent gene modules in primary and secondary glioblastoma.
Yan Mao, Yuzi Zhang, Qing Qu, Meizhong Zhao, Ying Lou, Junjun Liu, Ou huang, Xiaosong Chen, Jiayi Wu and Kunwei Shen
Mol. BioSyst., 2015, 11, 1029-1040
DOI: 10.1039/C4MB00710G, Paper
CAFs isolated from HER2+ patients secreted higher levels of IL6 which expanded cancer stem cells and activated multiple pathways, then induced trastuzumab resistance in HER2 positive breast cancer cells.
Mol. BioSyst., 2015, 11, 1041-1051
DOI: 10.1039/C5MB00003C, Paper
A computationally tractable pathway which helped in understanding the binding of matrix metalloproteinase inhibitors against an important class of MMPs is presented in this article.
Anastasia N. Sveshnikova, Fazoil I. Ataullakhanov and Mikhail A. Panteleev
Mol. BioSyst., 2015, 11, 1052-1060
DOI: 10.1039/C4MB00667D, Paper
A computational model of PAR1-stimulated platelet calcium signaling is developed to analyze the formation of platelet subpopulations. This occurs via a mitochondria-dependent decision-making mechanism. This is a stochastic phenomenon caused by a small number of PARs.
Wilson Karubiu, Soumendranath Bhakat, Lara McGillewie and Mahmoud E. S. Soliman
Mol. BioSyst., 2015, 11, 1061-1066
DOI: 10.1039/C4MB00631C, Paper
Herein, for the first time, we report the flap opening and closing in Plasmepsin proteases – plasmepsin II (PlmII) was used as a prototype model.
Mol. BioSyst., 2015, 11, 1067-1078
DOI: 10.1039/C4MB00573B, Paper
The cooperative material basis of the multi-component and multi-target mechanism of action of Traditional Chinese Medicine (TCM) is difficult to elucidate because of the current lack of appropriate techniques and strategies.
Mol. BioSyst., 2015, 11, 1079-1095
DOI: 10.1039/C4MB00675E, Paper
Protein kinases participate extensively in cellular signalling. Using Gaussian normal mode analysis of kinases in active and diverse inactive forms, authors show that structural fluctuations are significantly higher in inactive forms and are localized in functionally sensitive sites.
Manel Taamalli, Angelo D’Alessandro, Cristina Marrocco, Federica Gevi, Anna Maria Timperio and Lello Zolla
Mol. BioSyst., 2015, 11, 1096-1109
DOI: 10.1039/C4MB00567H, Paper
Recent physiological reports have documented how Cakile maritima Scop. Sea Rocket could accumulate high doses of Cd without altering its physiological parameters.
Mol. BioSyst., 2015, 11, 1110-1118
DOI: 10.1039/C4MB00629A, Paper
The distribution of GO molecular functions across different SCOP DNA-binding folds was studied. Majority of the folds were observed to perform more than one molecular function. This supports the notion that majority of DNA-binding proteins might follow divergent evolution.
Mol. BioSyst., 2015, 11, 1119-1133
DOI: 10.1039/C4MB00662C, Paper
The biomolecular recognition of typical flavanones, namely hesperidin and its aglycone hesperetin, by critical proteins has significant disparities, and these recognition distinctions may largely originate from the flexibility of protein structure and the structural characteristics of bioactive flavanones.
Gabriel Thieulin-Pardo, Thérèse Remy, Sabrina Lignon, Régine Lebrun and Brigitte Gontero
Mol. BioSyst., 2015, 11, 1134-1145
DOI: 10.1039/C5MB00035A, Paper
In this study, focused on C. reinhardtii phosphoribulokinase, we showed that CP12 catalyses a disulfide bridge between Cys243 and Cys249 on PRK. This disulfide bridge is essential for the GAPDH–CP12–PRK complex formation.
Mol. BioSyst., 2015, 11, 1146-1155
DOI: 10.1039/C4MB00682H, Paper
Acrylamide (ACR) is known to induce neurotoxicity in humans and occupational exposure to ACR has an effect on human health.
Seungjin Na, Eunok Paek, Jong-Soon Choi, Duwoon Kim, Seung Jae Lee and Joseph Kwon
Mol. BioSyst., 2015, 11, 1156-1164
DOI: 10.1039/C4MB00688G, Paper
Planned digestion with missed cleavage identified disulfide bonds of RNase A.
Mol. BioSyst., 2015, 11, 1165-1171
DOI: 10.1039/C5MB00080G, Paper
Improving the microbial tolerance to stresses is very important for bioprocesses.
Monika Kallubai, Aparna Rachamallu, Daniel Pushparaju Yeggoni and Rajagopal Subramanyam
Mol. BioSyst., 2015, 11, 1172-1183
DOI: 10.1039/C4MB00635F, Paper
Binding of lupeol compounds with plasma proteins.
Karl Peebo, Kaspar Valgepea, Andres Maser, Ranno Nahku, Kaarel Adamberg and Raivo Vilu
Mol. BioSyst., 2015, 11, 1184-1193
DOI: 10.1039/C4MB00721B, Paper
Allocation of protein expression costs between metabolic processes in slow and fast growing E. coli in defined rich medium.
Bin Liu, Longyun Fang, Junjie Chen, Fule Liu and Xiaolong Wang
Mol. BioSyst., 2015, 11, 1194-1204
DOI: 10.1039/C5MB00050E, Paper
MicroRNA precursor identification is an important task in bioinformatics.

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