Journal cover: Molecular BioSystems

Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.
Impact Factor 3.35 12 Issues per Year Indexed in MEDLINE
 
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Molecular BioSystems,
01 May 2014 , Issue 5,
Page 943 to 1212
Lyn H. Jones, Arjun Narayanan and Erik C. Hett
Mol. BioSyst., 2014, 10, 952-969
DOI: 10.1039/C4MB00018H, Review Article
Tyrosine biochemical diversity is reviewed.
 
Lei Yan, Jie Zhou, Yue Zheng, Adam S. Gamson, Benjamin T. Roembke, Shizuka Nakayama and Herman O. Sintim
Mol. BioSyst., 2014, 10, 970-1003
DOI: 10.1039/C3MB70304E, Review Article
This review highlights various methods that can be used for a sensitive detection of nucleic acids without using thermal cycling procedures, as is done in PCR or LCR.
 
Renxiang Yan, Jun Lin, Zhen Chen, Xiaofeng Wang, Lanqing Huang, Weiwen Cai and Ziding Zhang
Mol. BioSyst., 2014, 10, 1004-1013
DOI: 10.1039/C3MB70435A, Method
Locating the transmembrane regions of outer membrane proteins (OMPs) is highly important for deciphering their biological functions at both molecular and cellular levels.
 
Mol. BioSyst., 2014, 10, 1014-1022
DOI: 10.1039/C3MB70507B, Paper
Understanding the mechanisms of the pharmacological effects of herbal formulae from traditional Chinese medicine (TCM) is important for their appropriate application.
 
A. Sesilja Aranko, Jesper S. Oeemig, Dongwen Zhou, Tommi Kajander, Alexander Wlodawer and Hideo Iwaï
Mol. BioSyst., 2014, 10, 1023-1034
DOI: 10.1039/C4MB00021H, Paper
We introduced a nomenclature for split inteins and engineered mini-inteins. 21 new split inteins were created based on the four intein structures. trans-Splicing and cross-activity of 24 split inteins were systematically compared. >75% of the split inteins were active and >90% of the combinations were orthogonal.
 
Mol. BioSyst., 2014, 10, 1035-1042
DOI: 10.1039/C3MB70520J, Paper
Hydrogel-entrapped cultures and biofilms differentially express proteins involved in energy metabolism, iron uptake, biofilm formation, and purine biosynthesis.
 
Mol. BioSyst., 2014, 10, 1043-1054
DOI: 10.1039/C3MB70421A, Paper
Methanococcus maripaludis S2 is attractive for converting CO2 to methane. The first genome-scale model for its metabolism is developed, validated, and analyzed for methanogenesis.
 
Mol. BioSyst., 2014, 10, 1055-1062
DOI: 10.1039/C3MB70386J, Paper
Proliferative vitreoretinopathy (PVR) develops as a complication of rhegmatogenous retinal detachment (RRD).
 
Carlos Fernandez-Lozano, Enrique Fernández-Blanco, Kirtan Dave, Nieves Pedreira, Marcos Gestal, Julián Dorado and Cristian R. Munteanu
Mol. BioSyst., 2014, 10, 1063-1071
DOI: 10.1039/C3MB70489K, Paper
The current work presents the first classification model that predicts protein enzyme regulators using the Markov mean properties.
 
Mol. BioSyst., 2014, 10, 1072-1081
DOI: 10.1039/C3MB70564A, Paper
We establish dynamic miRNA expression profiling of COPD animal models and new discoveries of some differentially expressed miRNAs in COPD patients.
 
Ramachandra M. Bhaskara, Prachi Mehrotra, Ramaswamy Rakshambikai, Mutharasu Gnanavel, Juliette Martin and Narayanaswamy Srinivasan
Mol. BioSyst., 2014, 10, 1082-1093
DOI: 10.1039/C3MB70443B, Paper
An alignment-free approach effectively captures domain-architectural and functional similarities among multi-domain proteins.
 
Mol. BioSyst., 2014, 10, 1094-1103
DOI: 10.1039/C3MB70593E, Paper
Prenylated proteins sensitive to farnesyltransferase inhibitor treatment were identified by combining metabolic labeling with 2D-DIGE. Using this method, GNAI-1 and GNAI-2 were identified as potential novel prenylated proteins.
 
Bikash R. Sahoo, Jitendra Maharana, Gopal K. Bhoi, Santosh K. Lenka, Mahesh C. Patra, Manas R. Dikhit, Praveen K. Dubey, Sukanta K. Pradhan and Bijay K. Behera
Mol. BioSyst., 2014, 10, 1104-1116
DOI: 10.1039/C3MB70600A, Paper
A binding site analysis of adenosine triphosphate, muramyl dipeptide and imidazoquinoline, with mouse Nalp3 domains and free energy calculations.
 
Mol. BioSyst., 2014, 10, 1117-1125
DOI: 10.1039/C3MB70474B, Paper
Co-expression network analysis reveals the TIPH HBCtest potential biomarkers for discriminating chronic hepatitis B and the caused cirrhosis.
 
Fujian Tan, Ruizhi Yang, Xiaoxue Xu, Xiujie Chen, Yunfeng Wang, Hongzhe Ma, Xiangqiong Liu, Xin Wu, Yuelong Chen, Lei Liu and Xiaodong Jia
Mol. BioSyst., 2014, 10, 1126-1138
DOI: 10.1039/C3MB70554D, Paper
Drug repositioning, also known as drug repurposing or reprofiling, is the process of finding new indications for established drugs.
 
Mol. BioSyst., 2014, 10, 1139-1145
DOI: 10.1039/C4MB00063C, Paper
ATP binding cavity of human LMTK3 domain model.
 
Laura Comelli, Silvia Rocchiccioli, Salvatore Smirni, Alessandra Salvetti, Giovanni Signore, Lorenzo Citti, Maria Giovanna Trivella and Antonella Cecchettini
Mol. BioSyst., 2014, 10, 1146-1152
DOI: 10.1039/C3MB70544G, Paper
Characterization of VSMC-derived vesicles.
 
Longfei Du, Sifan Li, Lei Qi, Yurong Hou, Yan Zeng, Wei Xu, Hong Wang, Xiujuan Zhao and Changhao Sun
Mol. BioSyst., 2014, 10, 1153-1161
DOI: 10.1039/C4MB00044G, Paper
The mixture of OP pesticides induced oxidative stress, liver and renal dysfunction, disturbed the metabolism of lipids and amino acids, and interfered with the function of the thyroid gland.
 
Mol. BioSyst., 2014, 10, 1162-1171
DOI: 10.1039/C3MB70181F, Paper
Alignment of agonist ligands (the native autoinducer TP-1 violet and white) and the antagonist ligand (ligand 8, in blue) in the active site of LasR.
 
Mol. BioSyst., 2014, 10, 1172-1183
DOI: 10.1039/C3MB70616H, Paper
The interaction of spermine and its analogue, 1-naphthyl acetyl spermine with four double stranded DNA polynucleotides has been studied to understand the structural and thermodynamic basis of the binding.
 
M. L. Stanly Paul, Amandeep Kaur, Ankit Geete and M. Elizabeth Sobhia
Mol. BioSyst., 2014, 10, 1184-1195
DOI: 10.1039/C3MB70440H, Paper
New stage specific drug targets for contemporary drug discovery for leishmaniasis.
 
Mol. BioSyst., 2014, 10, 1196-1210
DOI: 10.1039/C4MB00013G, Paper
Protein kinase CK2, also known as casein kinase II, is related to various cellular events and is a potential target for numerous cancers.
 

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