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Journal cover: Molecular BioSystems

Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.
Impact Factor 3.183 12 Issues per Year Indexed in Medline
 
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Molecular BioSystems,
01 June 2015 , Issue 6,
Page 1475 to 1728
Andrea Urbani, Paola Roncada, Alessandra Modesti, Anna Maria Timperio, Luca Bini, Mauro Fasano and Massimo Castagnola
Mol. BioSyst., 2015, 11, 1485-1486
DOI: 10.1039/C5MB90021B, Editorial
From themed collection Proteomics
Inductive reasoning has been the corner stone of a large plethora of proteomics investigations, shifting the a priori paradigm of classical cellular and molecular biology to the experimental observation of protein modulation. These studies are now providing better definitions of their application framework.
 
Fiorella A. Solari, Margherita Dell'Aica, Albert Sickmann and René P. Zahedi
Mol. BioSyst., 2015, 11, 1487-1493
DOI: 10.1039/C5MB00024F, Opinion
From themed collection Proteomics
Peptide-centric bottom-up proteomics can lead to ambiguous results.
 
Esther Imperlini, Annamaria Mancini, Andreina Alfieri, Domenico Martone, Marianna Caterino, Stefania Orrù and Pasqualina Buono
Mol. BioSyst., 2015, 11, 1494-1506
DOI: 10.1039/C5MB00030K, Review Article
From themed collection Proteomics
Supraphysiological doses of doping agents, such as T/DHT and GH/IGF-1, affect cellular pathways associated with apoptosis and inflammation.
 
Gabriele De Sio, Andrew James Smith, Manuel Galli, Mattia Garancini, Clizia Chinello, Francesca Bono, Fabio Pagni and Fulvio Magni
Mol. BioSyst., 2015, 11, 1507-1514
DOI: 10.1039/C4MB00716F, Method
From themed collection Proteomics
The paper shows a new method for the application of Matrix Assisted Laser Desorption/Ionisation (MALDI) Mass Spectrometry Imaging (MSI) technology on formalin-fixed paraffin-embedded (FFPE) tissue samples.
 
Mol. BioSyst., 2015, 11, 1515-1524
DOI: 10.1039/C5MB00026B, Method
From themed collection Proteomics
A simple and rapid technique for construction of single domain antibody (VHH) library for ribosome display is described in this study.
 
Emanuela Scolamiero, Carla Cozzolino, Lucia Albano, Antonella Ansalone, Marianna Caterino, Graziella Corbo, Maria Grazia di Girolamo, Cristina Di Stefano, Adriano Durante, Giovanni Franzese, Ignazio Franzese, Giovanna Gallo, Paolo Giliberti, Laura Ingenito, Giovanni Ippolito, Basilio Malamisura, Pietro Mazzeo, Antonella Norma, Daniela Ombrone, Giancarlo Parenti, Silvana Pellecchia, Rita Pecce, Ippolito Pierucci, Roberta Romanelli, Anna Rossi, Massimo Siano, Teodoro Stoduto, Guglielmo R. D. Villani, Generoso Andria, Francesco Salvatore, Giulia Frisso and Margherita Ruoppolo
Mol. BioSyst., 2015, 11, 1525-1535
DOI: 10.1039/C4MB00729H, Paper
From themed collection Proteomics
This paper highlights the importance of metabolic profiling by LC-MS/MS and GC-MS of biological fluids for diagnosis of inborn errors of metabolism and confirms a high incidence of these disorders.
 
Michaela D. Filiou, Magdalena Soukupova, Christiane Rewerts, Christian Webhofer, Chris W. Turck and Giuseppina Maccarrone
Mol. BioSyst., 2015, 11, 1536-1542
DOI: 10.1039/C4MB00702F, Paper
From themed collection Proteomics
Repeatability of the 15N metabolic labeling workflow for quantitative proteomics in mouse plasma and brain specimens.
 
V. Matafora, M. Cuccurullo, A. Beneduci, O. Petrazzuolo, A. Simeone, P. Anastasio, R. Mignani, S. Feriozzi, A. Pisani, C. Comotti, A. Bachi and G. Capasso
Mol. BioSyst., 2015, 11, 1543-1551
DOI: 10.1039/C4MB00707G, Paper
From themed collection Proteomics
Discovery of early urinary biomarkers for Fabry disease in male and female adult patients revealed by proteomics.
 
Monica Sanna, Davide Firinu, Paolo Emilio Manconi, Maria Pisanu, Giuseppe Murgia, Valentina Piras, Massimo Castagnola, Irene Messana, Stefano Renato del Giacco and Tiziana Cabras
Mol. BioSyst., 2015, 11, 1552-1562
DOI: 10.1039/C4MB00719K, Paper
From themed collection Proteomics
Salivary proteomic investigation in SAPHO syndrome reveals significant variation of cystatins, histatins, aPRP, S100A12, suggesting their potential role as biomarkers.
 
Damiana Pieragostino, Michele D'Alessandro, Maria di Ioia, Claudia Rossi, Mirco Zucchelli, Andrea Urbani, Carmine Di Ilio, Alessandra Lugaresi, Paolo Sacchetta and Piero Del Boccio
Mol. BioSyst., 2015, 11, 1563-1572
DOI: 10.1039/C4MB00700J, Paper
From themed collection Proteomics
(1) Lipid profiling in MuS and OND patients. (2) Search of alterations associated with MuS. (3) Characterization of differences.
 
Maša Ždralević, Valentina Longo, Nicoletta Guaragnella, Sergio Giannattasio, Anna Maria Timperio and Lello Zolla
Mol. BioSyst., 2015, 11, 1573-1583
DOI: 10.1039/C4MB00660G, Paper
From themed collection Proteomics
A combined proteomic and metabolomic approach revealed new non-apoptotic roles of the metacaspase YCA1 gene in Saccharomyces cerevisiae, highlighting its involvement in the cell metabolism and stress response.
 
Virginia Correani, Laura Di Francesco, Isabella Cera, Giuseppina Mignogna, Alessandra Giorgi, Michele Mazzanti, Lorenzo Fumagalli, Cinzia Fabrizi, Bruno Maras and M. Eugenia Schininà
Mol. BioSyst., 2015, 11, 1584-1593
DOI: 10.1039/C4MB00703D, Paper
From themed collection Proteomics
Reversible redox modifications of the microglial proteome contribute to switching of these neuronal sentinel cells toward a neuroinflammatory phenotype.
 
Rita Ferreira, Paula Oliveira, Telma Martins, Sandra Magalhães, Fábio Trindade, Maria João Pires, Bruno Colaço, António Barros, Lúcio Santos, Francisco Amado and Rui Vitorino
Mol. BioSyst., 2015, 11, 1594-1602
DOI: 10.1039/C4MB00606B, Paper
From themed collection Proteomics
Bladder cancer is estimated to be the ninth most common malignancy with a high rate of recurrence and progression despite therapy, early diagnosis being crucial for timely intervention.
 
Maurizio Ronci, Giuseppina Catanzaro, Luisa Pieroni, Agnese Po, Zein Mersini Besharat, Viviana Greco, Stefano Levi Mortera, Isabella Screpanti, Elisabetta Ferretti and Andrea Urbani
Mol. BioSyst., 2015, 11, 1603-1611
DOI: 10.1039/C5MB00034C, Paper
From themed collection Proteomics
First proteomic characterization of sonic hedgehog human medulloblastoma stem-like cells.
 
Roberta Leone, Paola Giussani, Sara De Palma, Chiara Fania, Daniele Capitanio, Michele Vasso, Loredana Brioschi, Laura Riboni, Paola Viani and Cecilia Gelfi
Mol. BioSyst., 2015, 11, 1612-1621
DOI: 10.1039/C4MB00725E, Paper
From themed collection Proteomics
NO exposure of two human high grade glioma cell lines (CCF-STTG1 and T98G) characterized by a different proteomic profile shows differential ceramide distribution and proliferation.
 
Rita Romani, Francesca Fallarino, Irene Pirisinu, Mario Calvitti, Anna Caselli, Tania Fiaschi, Tania Gamberi, Davide Matino, Vincenzo N. Talesa, Emilio Donti, Paolo Puccetti, Alessandra Modesti and Francesca Magherini
Mol. BioSyst., 2015, 11, 1622-1632
DOI: 10.1039/C5MB00018A, Paper
From themed collection Proteomics
Characterization of two types of stem cells isolated from human amniotic fluid.
 
Luisa Pieroni, Stefano Levi Mortera, Viviana Greco, Vittorio Sirolli, Maurizio Ronci, Paolo Felaco, Giorgio Fucci, Silvia De Fulviis, Renato Massoud, Stefano Condò, Ambrogio Capria, Nicola Di Daniele, Sergio Bernardini, Andrea Urbani and Mario Bonomini
Mol. BioSyst., 2015, 11, 1633-1643
DOI: 10.1039/C5MB00058K, Paper
From themed collection Proteomics
We examine and compare the protein adsorption capacity and coagulation profiles of different haemodialysis membrane biomaterials.
 
Claudia D'Anna, Diego Cigna, Giorgia Costanzo, Andreina Bruno, Maria Ferraro, Serena Di Vincenzo, Laura Bianchi, Luca Bini, Mark Gjomarkaj and Elisabetta Pace
Mol. BioSyst., 2015, 11, 1644-1652
DOI: 10.1039/C5MB00188A, Paper
From themed collection Proteomics
The protein identified here may offer a new insight into deciphering damage caused by cigarette smoke.
 
Tania Gamberi, Francesca Magherini, Tania Fiaschi, Ida Landini, Lara Massai, Elisa Valocchia, Laura Bianchi, Luca Bini, Chiara Gabbiani, Stefania Nobili, Enrico Mini, Luigi Messori and Alessandra Modesti
Mol. BioSyst., 2015, 11, 1653-1667
DOI: 10.1039/C5MB00008D, Paper
From themed collection Proteomics
The cytotoxic mechanisms of the organogold(III) Aubipyc.
 
Claudia Martelli, Federica Iavarone, Luca D'Angelo, Morena Arba, Federica Vincenzoni, Ilaria Inserra, Daniela Delfino, Diana Valeria Rossetti, Marta Caretto, Luca Massimi, Gianpiero Tamburrini, Concezio Di Rocco, Massimo Caldarelli, Irene Messana, Massimo Castagnola, Maria Teresa Sanna and Claudia Desiderio
Mol. BioSyst., 2015, 11, 1668-1683
DOI: 10.1039/C5MB00076A, Paper
From themed collection Proteomics
The proteomic study of pediatric brain tumors tissues by top-down/bottom-up platforms revealed different expression profiles and potential malignancy biomarkers.
 
Marian Madar, Elena Bencurova, Patrik Mlynarcik, André M. Almeida, Renata Soares, Katarina Bhide, Lucia Pulzova, Andrej Kovac, Ana V. Coelho and Mangesh Bhide
Mol. BioSyst., 2015, 11, 1684-1695
DOI: 10.1039/C5MB00027K, Paper
From themed collection Proteomics
Borrelia and Francisella interact differently with complement regulatory proteins from various hosts, which influences the disease development and ecology of pathogens.
 
Federica Ciregia, Laura Giusti, Maurizio Ronci, Marco Bugliani, Isabella Piga, Luisa Pieroni, Claudia Rossi, Piero Marchetti, Andrea Urbani and Antonio Lucacchini
Mol. BioSyst., 2015, 11, 1696-1707
DOI: 10.1039/C5MB00022J, Paper
From themed collection Proteomics
Proteomic analysis of the protein expression profiles of enriched mitochondrial preparations of rat INS-1E β cells treated with palmitate in the presence and in the absence of GLP-1.
 
Francesca Raimondo, Samuele Corbetta, Andrea Savoia, Clizia Chinello, Marta Cazzaniga, Francesco Rocco, Silvano Bosari, Marco Grasso, Giorgio Bovo, Fulvio Magni and Marina Pitto
Mol. BioSyst., 2015, 11, 1708-1716
DOI: 10.1039/C5MB00020C, Paper
From themed collection Proteomics
Set-up of a specific protocol for membrane protein analysis, applied to label free, comparative proteomics of renal cell carcinoma microdomains.
 
G. Grande, D. Milardi, F. Vincenzoni, G. Pompa, A. Biscione, A. L. Astorri, E. Fruscella, A. De Luca, I. Messana, M. Castagnola and R. Marana
Mol. BioSyst., 2015, 11, 1717-1725
DOI: 10.1039/C5MB00071H, Paper
From themed collection Proteomics
The chemical composition of the cervical mucus (CM), its physical characteristics and the volume of secretion change cyclically throughout the menstrual cycle.
 

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