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Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.
Impact Factor 3.183 12 Issues per Year Indexed in MEDLINE
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Molecular BioSystems,
01 March 2015 , Issue 3,
Page 667 to 970
Mol. BioSyst., 2015, 11, 678-697
DOI: 10.1039/C4MB00571F, Review Article
This review represents a novel look at the many sources, cysteine targets, and signaling processes of ROS in the mitochondria.
Mol. BioSyst., 2015, 11, 698-713
DOI: 10.1039/C4MB00586D, Review Article
We present the principles, advantages, and possible limitations of ESI and MALDI mass spectrometry-based methodologies for the analysis of lipid species.
Chenglin Liu, Jing Su, Fei Yang, Kun Wei, Jinwen Ma and Xiaobo Zhou
Mol. BioSyst., 2015, 11, 714-722
DOI: 10.1039/C4MB00677A, Method
The Library of Integrated Network-based Cellular Signatures (LINCS) L1000 big data provide gene expression profiles induced by over 10 000 compounds, shRNAs, and kinase inhibitors using the L1000 platform.
Mol. BioSyst., 2015, 11, 723-733
DOI: 10.1039/C4MB00620H, Paper
In this work, a CoMFA model and molecular dynamics simulations provide guidelines for drug development of SIRT2 inhibitors.
Aitor de las Heras, Esteban Martínez-García, Maria Rosa Domingo-Sananes and Víctor de Lorenzo
Mol. BioSyst., 2015, 11, 734-742
DOI: 10.1039/C4MB00557K, Paper
The functional boundaries of the Pu promoter can be expanded by overproduction of both sigma-54 and the transcriptional regulator XylR.
Paul Dowling, Damian Pollard, AnneMarie Larkin, Michael Henry, Paula Meleady, Kathy Gately, Kenneth O'Byrne, Martin P. Barr, Vincent Lynch, Jo Ballot, John Crown, Michael Moriarty, Emmet O'Brien, Ross Morgan and Martin Clynes
Mol. BioSyst., 2015, 11, 743-752
DOI: 10.1039/C4MB00384E, Paper
Role of hnRNPA2B1 in lung cancer.
Xiaoxue Wang, Jie Zhang, Qingyu Huang, Ambreen Alamdar, Meiping Tian, Liangpo Liu and Heqing Shen
Mol. BioSyst., 2015, 11, 753-759
DOI: 10.1039/C4MB00565A, Paper
A metabolomics study was conducted to unveil the metabolic profiling of rats exposed to benzo(a)pyrene, and twelve differentiated metabolites were identified.
Meng Zhou, Xiaojun Wang, Jiawei Li, Dapeng Hao, Zhenzhen Wang, Hongbo Shi, Lu Han, Hui Zhou and Jie Sun
Mol. BioSyst., 2015, 11, 760-769
DOI: 10.1039/C4MB00511B, Paper
Accumulated evidence has shown that long non-coding RNAs (lncRNA) act as a widespread layer in gene regulatory networks and are involved in a wide range of biological processes.
Mol. BioSyst., 2015, 11, 770-782
DOI: 10.1039/C4MB00651H, Paper
Low ethanol tolerance is a crucial factor that restricts the feasibility of bioethanol production in renewable cyanobacterial systems.
Tannaz Faal, Pamela T. Wong, Shengzhuang Tang, Alexa Coulter, Yumay Chen, Christina H. Tu, James R. Baker, Seok Ki Choi and Matthew A. Inlay
Mol. BioSyst., 2015, 11, 783-790
DOI: 10.1039/C4MB00581C, Paper
Here, we synthesized and validated a photocaged hydroxytamoxifen molecule to achieve spatiotemporal control of gene expression with light.
Zhihua Cai, Dong Xu, Qing Zhang, Jiexia Zhang, Sai-Ming Ngai and Jianlin Shao
Mol. BioSyst., 2015, 11, 791-800
DOI: 10.1039/C4MB00659C, Paper
The ensemble-based feature selection method presents the merit of acquisition of more informative and compact features than those obtained by individual methods.
Francisco Ferreira Duarte Junior, Quirino Alves de Lima Neto, Fabiana dos Santos Rando, Douglas Vinícius Bassalobre de Freitas, José Renato Pattaro Júnior, Lorena Gomes Polizelli, Roxelle Ethienne Ferreira Munhoz, Flavio Augusto Vicente Seixas and Maria Aparecida Fernandez
Mol. BioSyst., 2015, 11, 801-808
DOI: 10.1039/C4MB00595C, Paper
Bioinformatic tools and PCR expression experiments were used to identify a new noncoding RNA homologous to sbRNA in the Bombyx mori genome.
Mol. BioSyst., 2015, 11, 809-818
DOI: 10.1039/C4MB00608A, Paper
Investigation for substrate selectivity and active site access channels of GH3.1, a critical enzyme involved in modulating levels of cellular auxins/IAA.
Mol. BioSyst., 2015, 11, 819-825
DOI: 10.1039/C4MB00646A, Paper
A predictor PredHydroxy, based on position weight amino acids composition, 8 high-quality indices and support vector machines, is designed to identify hydroxyproline and hydroxylysine sites.
Shasha He, Xiaolin Hou, Xiaolong Xu, Changrong Wan, Peng Yin, Xiaoxi Liu, Yuping Chen, Banchao Shu, Fenghua Liu and Jianqin Xu
Mol. BioSyst., 2015, 11, 826-834
DOI: 10.1039/C4MB00495G, Paper
We employed comparative proteomics to reveal a heat stress-induced injury mechanism in rat small intestine.
Mol. BioSyst., 2015, 11, 835-843
DOI: 10.1039/C4MB00579A, Paper
Spermatogonial stem cells (SSCs) are responsible for sustained spermatogenesis throughout the reproductive life of the male.
Martin Piskacek, Anna Vasku, Roman Hajek and Andrea Knight
Mol. BioSyst., 2015, 11, 844-851
DOI: 10.1039/C4MB00672K, Paper
Analysis of E2A, MLL, FOXO3 and p53 structural data defines fundamental requirements and sheds light on the ambiguous 9aaTAD domain.
Mol. BioSyst., 2015, 11, 852-858
DOI: 10.1039/C4MB00566J, Paper
Glyphosate is one of the most commonly used broad-spectrum herbicides with little to no hazard to animals, human beings, or the environment.
Qing-yong Chen, De-min Jiao, Li-feng Wang, Lishan Wang, Hui-zhen Hu, Jia Song, Jie Yan, Li-jun Wu and Jian-guo Shi
Mol. BioSyst., 2015, 11, 859-868
DOI: 10.1039/C4MB00336E, Paper
Crosstalk between Wnt pathways and adherens junction is associated with NSCLC. Curcumin blocks cell proliferation and migration in non-small cell cancer by regulating EGR-1.
Aili Zhang, Ting Zhang, Emma A. Hall, Sean Hutchinson, Max J. Cryle, Luet-Lok Wong, Weihong Zhou and Stephen G. Bell
Mol. BioSyst., 2015, 11, 869-881
DOI: 10.1039/C4MB00665H, Paper
The structure of CYP109B1 from Bacillus subtilis, which catalyses the oxidation of ionones, has been determined. This will allow the future design of more efficient biocatalytic monooxygenase systems.
Qianfen Wan, Guangyao Wu, Qinghua He, Huiru Tang and Yulan Wang
Mol. BioSyst., 2015, 11, 882-891
DOI: 10.1039/C4MB00622D, Paper
T-2 toxin is a common contaminant in grains and animal feedstuff, which becomes an increasing threat to human and animal health due to its high toxicity.
Mol. BioSyst., 2015, 11, 892-897
DOI: 10.1039/C4MB00650J, Paper
By fusing multiple features and using deep learning algorithms, a lncRNA-MFDL predictor was developed to identify lncRNAs, which is much more effective and robust.

Human 3-hydroxyanthranilate 3,4-dioxygenase (3HAO) dynamics and reaction, a multilevel computational study

H. Brkić, B. Kovačević and S. Tomić
Mol. BioSyst., 2015, 11, 898-907
DOI: 10.1039/C4MB00668B, Paper
The 3-Ohaa oxidation mechanism catalysed by 3HAO and influence of mutations on the 3HAO structure and dynamics are presented.
Soraya Hölper, Hendrik Nolte, Eva Bober, Thomas Braun and Marcus Krüger
Mol. BioSyst., 2015, 11, 908-922
DOI: 10.1039/C4MB00490F, Paper
An in vivo SILAC-based quantitative proteomics approach to analyse protein abundances and acetylation levels under diabetic conditions.
Xiaowei Zhao, Qiao Ning, Meiyu Ai, Haiting Chai and Minghao Yin
Mol. BioSyst., 2015, 11, 923-929
DOI: 10.1039/C4MB00680A, Paper
S-Glutathionylation is a reversible protein post-translational modification, which generates mixed disulfides between glutathione (GSH) and cysteine residues, playing an important role in regulating protein stability, activity, and redox regulation.

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