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Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
Impact Factor 3.183 12 Issues per Year Indexed in Medline
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Molecular BioSystems,
01 July 2015 , Issue 7,
Page 1729 to 2104
Mohamad Hafizi Abu Bakar, Mohamad Roji Sarmidi, Kian-Kai Cheng, Abid Ali Khan, Chua Lee Suan, Hasniza Zaman Huri and Harisun Yaakob
Mol. BioSyst., 2015, 11, 1742-1774
DOI: 10.1039/C5MB00158G, Review Article
From themed collection 2015 Hot Articles in Molecular BioSystems
This paper highlights the metabolomic roles in systems biology towards the elucidation of metabolic mechanisms in obesity and type 2 diabetes.
Chung-Min Park, Laksiri Weerasinghe, Jacob J. Day, Jon M. Fukuto and Ming Xian
Mol. BioSyst., 2015, 11, 1775-1785
DOI: 10.1039/C5MB00216H, Review Article
From themed collection Chemical Biology in Molecular BioSystems
This review article summarizes known knowledge about both small molecule persulfides and protein persulfides, including their preparation/detection methods, reactions, and biological implications.
Mol. BioSyst., 2015, 11, 1786-1793
DOI: 10.1039/C5MB00141B, Method
DNA methylation is essential not only in cellular differentiation but also in diseases.
Mol. BioSyst., 2015, 11, 1794-1801
DOI: 10.1039/C5MB00119F, Method
Coiled coils are characteristic rope-like protein structures, constituted by one or more heptad repeats.
Mol. BioSyst., 2015, 11, 1802-1819
DOI: 10.1039/C5MB00117J, Method
Learned parameters and prediction accuracy point to the reproducibility of naive Wnt Bayesian networks with missing and complete observations.
Jan Oliver Jost, Alfred Hanswillemenke and Dirk Schwarzer
Mol. BioSyst., 2015, 11, 1820-1823
DOI: 10.1039/C5MB00326A, Communication
Histone deacetylases are important drug targets, which are difficult to characterize due to their poor accessibility.
Giulia Menichetti, Ginestra Bianconi, Gastone Castellani, Enrico Giampieri and Daniel Remondini
Mol. BioSyst., 2015, 11, 1824-1831
DOI: 10.1039/C5MB00143A, Paper
From themed collection 2015 Hot Articles in Molecular BioSystems
We characterize cancer and ageing cell states with a multiscale network entropy approach, measuring “parameter space” available to the cell.
Zicheng Huang, Wei Shao, Jinping Gu, Xiaomin Hu, Yuanzhi Shi, Wenqi Xu, Caihua Huang and Donghai Lin
Mol. BioSyst., 2015, 11, 1832-1840
DOI: 10.1039/C5MB00019J, Paper
From themed collection 2015 Hot Articles in Molecular BioSystems
Culture media significantly affect cellular metabolic profiling.
Dean A. Tolla, Patricia J. Kiley, Jason G. Lomnitz and Michael A. Savageau
Mol. BioSyst., 2015, 11, 1841-1849
DOI: 10.1039/C5MB00055F, Paper
From themed collection 2015 Hot Articles in Molecular BioSystems
Activation of a regulatory protein by interruption of a futile cycle involves a trade-off between response time and energy expenditure.
Mol. BioSyst., 2015, 11, 1850-1856
DOI: 10.1039/C5MB00170F, Paper
From themed collection Chemical Biology in Molecular BioSystems
Microsecond molecular dynamics simulations reveal structural and functional features of Noxa, an intrinsically disordered protein, at atomic-level resolution.
Mol. BioSyst., 2015, 11, 1857-1866
DOI: 10.1039/C5MB00036J, Paper
The binding mode between benzimidazole-based inhibitors and RSVF protein was revealed by docking and molecular dynamics simulations.
Mol. BioSyst., 2015, 11, 1867-1875
DOI: 10.1039/C5MB00166H, Paper
Jhdm1b knockdown cells enhanced glutaminolysis to maintain the Krebs cycle by upregulating RIP3 expression.
Wei Liu, Qiuyu Wang, Jianmei Zhao, Chunlong Zhang, Yuejuan Liu, Jian Zhang, Xuefeng Bai, Xuecang Li, Houming Feng, Mingzhi Liao, Wei Wang and Chunquan Li
Mol. BioSyst., 2015, 11, 1876-1886
DOI: 10.1039/C5MB00044K, Paper
Accurately predicting the risk of cancer relapse or death is important for clinical utility.
Mol. BioSyst., 2015, 11, 1887-1896
DOI: 10.1039/C5MB00251F, Paper
L-Asparaginases belong to a family of amidohydrolases that catalyze the conversion of L-asparagine into L-aspartic acid and ammonia.
C. Castro, W. Briggs, G. K. Paschos, G. A. FitzGerald and J. L. Griffin
Mol. BioSyst., 2015, 11, 1897-1906
DOI: 10.1039/C5MB00032G, Paper
Metabolomics has been used to analyse adipose tissue in mice with an adipocyte-specific deletion of Arntl, showing the importance of the peripheral circadian clock in metabolic regulation. Arntl induces global changes in both white and brown adipose tissues which were distinct for the two tissues.
Mol. BioSyst., 2015, 11, 1907-1913
DOI: 10.1039/C5MB00089K, Paper
The recent sequencing revolution driven by high-throughput technologies has led to rapid accumulation of 16S rRNA sequences for microbial communities.
Goutam Mukherjee, Pancham Lal Gupta and B. Jayaram
Mol. BioSyst., 2015, 11, 1914-1924
DOI: 10.1039/C5MB00118H, Paper
Metabolism studies are an essential integral part of ADMET profiling of drug candidates to evaluate their safety and efficacy.
Mol. BioSyst., 2015, 11, 1925-1932
DOI: 10.1039/C5MB00105F, Paper
Gastric cancer is the third leading cause of cancer-related death in the world.
Zhe Wang, Gaozhi Chen, Linfeng Chen, Xing Liu, Weitao Fu, Yali Zhang, Chenglong Li, Guang Liang and Yuepiao Cai
Mol. BioSyst., 2015, 11, 1933-1938
DOI: 10.1039/C5MB00085H, Paper
From themed collection Chemical Biology in Molecular BioSystems
The residues R90 and Y102 of MD-2 are hot spot residues that contribute significantly to the affinity of curcumin binding.
Samuel M. D. Oliveira, Jerome G. Chandraseelan, Antti Häkkinen, Nadia S. M. Goncalves, Olli Yli-Harja, Sofia Startceva and Andre S. Ribeiro
Mol. BioSyst., 2015, 11, 1939-1945
DOI: 10.1039/C5MB00012B, Paper
We constructed a single-copy repressilator (SCR) by implementing the original repressilator circuit on a single-copy F-plasmid.
Tulin Ersahin, Nurcan Tuncbag and Rengul Cetin-Atalay
Mol. BioSyst., 2015, 11, 1946-1954
DOI: 10.1039/C5MB00101C, Paper
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signalling pathway is hyperactivated or altered in many cancer types and regulates a broad range of cellular processes including survival, proliferation, growth, metabolism, angiogenesis and metastasis.
Mol. BioSyst., 2015, 11, 1955-1972
DOI: 10.1039/C5MB00088B, Paper
Structural water and protein plasticity are important factors for BACE1 targeted ligand virtual screening.
Mol. BioSyst., 2015, 11, 1973-1979
DOI: 10.1039/C5MB00073D, Paper
From themed collection Chemical Biology in Molecular BioSystems
Inhibitory activities of selected benzoic acid derivatives against phospholipase A2.
Ying Qi, Xiaoli Zhang, Yani Kang, Jun Wu, Jian Chen, Hua Li, Yan Guo, Bingya Liu, Zhifeng Shao and Xiaodong Zhao
Mol. BioSyst., 2015, 11, 1980-1986
DOI: 10.1039/C5MB00233H, Paper
Transcriptome analysis of EZH2 responsive genes reveals ANXA6 as a new EZH2 target involving proliferation in gastric cancer cells.
Rajagopalan Muthukumaran, Balasubramanian Sangeetha and Ramaswamy Amutha
Mol. BioSyst., 2015, 11, 1987-1999
DOI: 10.1039/C5MB00194C, Paper
Structural dynamics of human ORF1p emphasizes the role of Tyr282 in regulating ribonucleoprotein complex formation.

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