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Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
Impact Factor 3.21 12 Issues per Year Indexed in Medline
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Molecular BioSystems,
01 December 2015 , Issue 12,
Page 3197 to 3426
Philippe Nghe, Wim Hordijk, Stuart A. Kauffman, Sara I. Walker, Francis J. Schmidt, Harry Kemble, Jessica A. M. Yeates and Niles Lehman
Mol. BioSyst., 2015, 11, 3206-3217
DOI: 10.1039/C5MB00593K, Review Article
Akin to biological networks, prebiotic chemical networks can evolve and we have identified six key parameters that govern their evolution.
Chunguang Ren, Satoshi Nagao, Masaru Yamanaka, Hirofumi Komori, Yasuhito Shomura, Yoshiki Higuchi and Shun Hirota
Mol. BioSyst., 2015, 11, 3218-3221
DOI: 10.1039/C5MB00545K, Communication
From themed collection Chemical Biology in Molecular BioSystems
High-order oligomers increased whereas N-terminal domain swapping and C-terminal domain swapping were elucidated by the insertion of Gly residues at the major hinge loop of cytochrome c552.
Snezana Stefanovic, Brett A. DeMarco, Ayana Underwood, Kathryn R. Williams, Gary J. Bassell and Mihaela Rita Mihailescu
Mol. BioSyst., 2015, 11, 3222-3230
DOI: 10.1039/C5MB00423C, Paper
Fragile X syndrome, the most common cause of inherited intellectual disability, is caused by a trinucleotide CGG expansion in the 5′-untranslated region of the FMR1 gene, which leads to the loss of expression of the fragile X mental retardation protein (FMRP).
Max C. Waldhauer, Silvan N. Schmitz, Constantin Ahlmann-Eltze, Jan G. Gleixner, Carolin C. Schmelas, Anna G. Huhn, Charlotte Bunne, Magdalena Büscher, Max Horn, Nils Klughammer, Jakob Kreft, Elisabeth Schäfer, Philipp A. Bayer, Stephen G. Krämer, Julia Neugebauer, Pierre Wehler, Matthias P. Mayer, Roland Eils and Barbara Di Ventura
Mol. BioSyst., 2015, 11, 3231-3243
DOI: 10.1039/C5MB00341E, Paper
From themed collection 10th Anniversary of Molecular BioSystems
While using a serine (S) as linker for circularization increases the thermostability, a longer linker (RGKCWE) leads to reduced aggregation after heat shock at elevated temperatures.
Mol. BioSyst., 2015, 11, 3244-3252
DOI: 10.1039/C5MB00443H, Paper
From themed collection 2015 Hot Articles in Molecular BioSystems
MicroRNAs (miRNAs) are small non-coding RNAs that can regulate their target gene expressions at the post-transcriptional level.
Feng Li, Yun Xiao, Fei Huang, Wei Deng, Hongying Zhao, Xinrui Shi, Shuyuan Wang, Xuexin Yu, Lianfeng Zhang, Zujing Han, Longhai Luo, Qianhua Zhu, Wei Jiang, Shujun Cheng, Xia Li and Kaitai Zhang
Mol. BioSyst., 2015, 11, 3253-3263
DOI: 10.1039/C5MB00474H, Paper
From themed collection 2015 Hot Articles in Molecular BioSystems
Identification of spatiotemporal-specific lncRNAs during the development of multiple tissues in rhesus.
Mol. BioSyst., 2015, 11, 3264-3272
DOI: 10.1039/C5MB00511F, Paper
From themed collection 2015 Hot Articles in Molecular BioSystems
Viruses wrapped with peptide ligand-functionalized PEG allowed differentiation of biomarker levels on prostate cancer cells distinguishing disease aggressiveness.
Mol. BioSyst., 2015, 11, 3273-3278
DOI: 10.1039/C5MB00532A, Paper
From themed collection 2015 Hot Articles in Molecular BioSystems
We have examined how sequence context affects the ability of (N204D:L272A) mutants of uracil DNA glycosylase to cleave CX mismatches.
Felicia Ikolo, Meng Zhang, Dean J. Harrington, Carl Robinson, Andrew S. Waller, Iain C. Sutcliffe and Gary W. Black
Mol. BioSyst., 2015, 11, 3279-3286
DOI: 10.1039/C5MB00543D, Paper
From themed collection 2015 Hot Articles in Molecular BioSystems
We present the first direct evidence that a streptococcal parvulin lipoprotein has PPIase activity, which likely affects virulence factor secretion.
Min Liu, Kaige Zhou, Hailong Li, Xin Dong, Guangguo Tan, Yifeng Chai, Weizhong Wang and Xiaoying Bi
Mol. BioSyst., 2015, 11, 3287-3296
DOI: 10.1039/C5MB00470E, Paper
From themed collection 2015 Hot Articles in Molecular BioSystems
A panel of serum metabolite markers (glutamine, kynurenine, and LysoPC(18:2)) was identified as candidate diagnostic biomarkers for post-stroke cognitive impairment.
Ninna Granucci, Farhana R. Pinu, Ting-Li Han and Silas G. Villas-Boas
Mol. BioSyst., 2015, 11, 3297-3304
DOI: 10.1039/C5MB00292C, Paper
Based on the metabolic overflow concept, a given metabolite is secreted to the extracellular medium when its intracellular levels increase. But this phenomenon can only be truly observed experimentally by using dynamic metabolite level measurements of both intra and extracellular media under time series experiments.
Mol. BioSyst., 2015, 11, 3305-3315
DOI: 10.1039/C5MB00386E, Paper
This work presents an NMR-based metabolomic approach to study metabolic processes in D. melanogaster that exhibit a diurnal rhythm.
Mol. BioSyst., 2015, 11, 3316-3331
DOI: 10.1039/C5MB00476D, Paper
From themed collection Chemical Biology in Molecular BioSystems
Drug repurposing to explore target space has been gaining pace over the past decade with the upsurge in the use of systematic approaches for computational drug discovery.
Warren D. Anderson, Hirenkumar K. Makadia, Andrew D. Greenhalgh, James S. Schwaber, Samuel David and Rajanikanth Vadigepalli
Mol. BioSyst., 2015, 11, 3332-3346
DOI: 10.1039/C5MB00488H, Paper
Neuroinflammation due to glial activation has been linked to many CNS diseases.
Hongli Liu, Xiaoli An, Shuyan Li, Yuwei Wang, Jiazhong Li and Huanxiang Liu
Mol. BioSyst., 2015, 11, 3347-3354
DOI: 10.1039/C5MB00499C, Paper
From themed collection Chemical Biology in Molecular BioSystems
R-Bicalutamide is a first generation antiandrogen used to treat prostate cancer, which inhibits androgen action by competitively binding to the androgen receptor (AR).
Mol. BioSyst., 2015, 11, 3355-3361
DOI: 10.1039/C5MB00555H, Paper
From themed collection Chemical Biology in Molecular BioSystems
Dynamics of endogenous SeNPs in selenite-exposed cancer cells provide a strategy for designing efficient intracellular self-assembling systems for overcoming drug resistance.
Mol. BioSyst., 2015, 11, 3362-3377
DOI: 10.1039/C5MB00468C, Paper
Network-based and cheminformatics approaches identify novel lead molecules for CXCR4, a key gene prioritized in oral cancer.
Eung-Sam Kim, Animesh Samanta, Hui Shan Cheng, Zhaobing Ding, Weiping Han, Luisella Toschi and Young Tae Chang
Mol. BioSyst., 2015, 11, 3378-3386
DOI: 10.1039/C5MB00525F, Paper
K-Ras/PI3K knock-in mutation and treatment of kinase inhibitors altered the intracellular amino acid metabolism compared to the wild-type breast cell.
Zhongfeng Li, Xinfeng Liu, Juan Wang, Jian Gao, Shuzhen Guo, Kuo Gao, Hongxue Man, Yingfeng Wang, Jianxin Chen and Wei Wang
Mol. BioSyst., 2015, 11, 3387-3396
DOI: 10.1039/C5MB00489F, Paper
The NMR-based metabolomics approach showed good performance in identifying diagnostic urinary biomarkers, providing new insights into the metabolic process related to UAP.
Mol. BioSyst., 2015, 11, 3397-3406
DOI: 10.1039/C5MB00413F, Paper
Epithelial to mesenchymal transition (EMT) is a biological process that plays a crucial role in cancer metastasis.
Mol. BioSyst., 2015, 11, 3407-3414
DOI: 10.1039/C5MB00568J, Paper
SUMOylation (the process of adding the SUMO [small ubiquitin-like modifier] to substrates) is an important post-translational modification of critical proteins in multiple processes. The kinetics parameters of pre-SUMO1-3 by its protease SENP2 is determined by a quantitative FRET assay in real time.
Mol. BioSyst., 2015, 11, 3415-3424
DOI: 10.1039/C5MB00602C, Paper
N-linked glycosylation of Fc at N297 plays an important role in its effector function, aberrance of which would cause disease pathogenesis.

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