Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
 
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Molecular BioSystems,
01 January 2017 , Issue 1,
Page 1 to 226
Jennifer A. E. Payne, Melanie Schoppet, Mathias Henning Hansen and Max J. Cryle
Mol. BioSyst., 2017, 13, 9-22
DOI: 10.1039/C6MB00675B, Opinion
From themed collection 2016 Hot Articles in Molecular BioSystems
Highlighting recent important discoveries from the biosynthesis of peptides by linear non-ribosomal peptide synthetase (NRPS) machineries.
 
Mol. BioSyst., 2017, 13, 23-31
DOI: 10.1039/C6MB00644B, Review Article
From themed collection 2016 Hot Articles in Molecular BioSystems
Deregulating ClpP activity either through inhibition or overactivation could lead to antibacterial activity.
 
Mol. BioSyst., 2017, 13, 32-41
DOI: 10.1039/C6MB00654J, Review Article
Studies using experimental model systems have revealed significant effects of the intracellular environment on the interactions of DNA and RNA.
 
Sayem Miah, Charles A. S. Banks, Mark K. Adams, Laurence Florens, Kiven E. Lukong and Michael P. Washburn
Mol. BioSyst., 2017, 13, 42-55
DOI: 10.1039/C6MB00639F, Review Article
Understanding the complexity of cancer biology requires extensive information about the cancer proteome over the course of the disease.
 
Mol. BioSyst., 2017, 13, 56-72
DOI: 10.1039/C6MB00657D, Review Article
Erythropoietin (Epo) is a glycoprotein with important roles in erythropoiesis and other biological processes by serving as a hormone, a cytokine, or a growth factor. At least in part, the Epo multifunctionality is driven by its partners. The goal of this article is to evaluate the roles of intrinsic disorder in the functions of Epo and its primary interactors, EpoR, βCR, and HIF-1α.
 
Mol. BioSyst., 2017, 13, 73-82
DOI: 10.1039/C6MB00742B, Communication
Alcohol-induced liver injury (ALD) shows obvious metabolic disorders, categorized by a wide range of metabolite abnormalities.
 
Yiqing Zhou, Weichao Li, Mingli Wang, Xixi Zhang, Haibing Zhang, Xiaofeng Tong and Youli Xiao
Mol. BioSyst., 2017, 13, 83-91
DOI: 10.1039/C6MB00691D, Communication
We reported the proteome-wide profiling of cellular targets of celastrol in HeLa cells via competitive chemoproteomics approach utilizing a cysteine-targeting activity-based probe.
 
Faraz K. Mardakheh, Heba Z. Sailem, Sandra Kümper, Christopher J. Tape, Ryan R. McCully, Angela Paul, Sara Anjomani-Virmouni, Claus Jørgensen, George Poulogiannis, Christopher J. Marshall and Chris Bakal
Mol. BioSyst., 2017, 13, 92-105
DOI: 10.1039/C6MB00701E, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
A combined proteomics and bioinformatics strategy for mapping interactome dynamics via assessment of subcellular protein–protein colocalisations.
 
Mol. BioSyst., 2017, 13, 106-121
DOI: 10.1039/C6MB00596A, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Today obesity and type 2 diabetes (T2D) have both reached epidemic proportions.
 
C. F. Baez, V. A. Barel, A. M. T. de Souza, C. R. Rodrigues, R. B. Varella and N. Cirauqui
Mol. BioSyst., 2017, 13, 122-131
DOI: 10.1039/C6MB00645K, Paper
A structural and mutational analysis of ZIKV identifies some protein regions as potential anti-ZIKV targets.
 
Heli Tan, Tuoqi Liu, Jiajun Zhang and Tianshou Zhou
Mol. BioSyst., 2017, 13, 132-141
DOI: 10.1039/C6MB00729E, Paper
Chromosomal regions are often dynamically modified by histones, leading to the uncertainty of nucleosome positions.
 
Mol. BioSyst., 2017, 13, 142-155
DOI: 10.1039/C6MB00646A, Paper
Network modeling and molecular dynamic studies reveal the perturbation in communication pathways as a mechanism of allosteric inhibition in anthranilate synthase.
 
Jin-Mai Zhang, Cheng Jiang, Wei Ye, Ray Luo and Hai-Feng Chen
Mol. BioSyst., 2017, 13, 156-164
DOI: 10.1039/C6MB00630B, Paper
The allosteric pathway of a THF riboswitch is from the allosteric site of THF to the expression platform.
 
Mol. BioSyst., 2017, 13, 165-182
DOI: 10.1039/C6MB00441E, Paper
Simulations reveal molecular-level details of aggregation of amyloid β peptide that is implicated in fatal Alzheimer's disease.
 
Mol. BioSyst., 2017, 13, 183-192
DOI: 10.1039/C6MB00619A, Paper
Exploring how the structure of a gene regulatory network differs between two different disease states is fundamental for understanding the biological mechanisms behind disease development and progression.
 
Mol. BioSyst., 2017, 13, 193-207
DOI: 10.1039/C6MB00730A, Paper
The mechanistic and structural basis of srII–htrII signaling mediated by a HAMP four-helix bundle in Natronomonas pharaonis.
 
Mol. BioSyst., 2017, 13, 208-214
DOI: 10.1039/C6MB00690F, Paper
Ca2+ ion binds tightly to the center of the selectivity filter of voltage-gated calcium channels.
 
Dong Zhang, Yongchun Cui, Bin Li, Xiaokang Luo, Bo Li and Yue Tang
Mol. BioSyst., 2017, 13, 215-224
DOI: 10.1039/C6MB00649C, Paper
miR-155 regulates high glucose-induced cardiac fibrosis via the TGF-β/Smad 2 pathway.
 

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50 citations
With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent to develop automated methods for analyzing the relationship between the sequences and their functions.
DOI: 10.1039/C5MB00155B
Published: 05 Jun 2015
15 citations
Immunoglobulins, also called antibodies, are a group of cell surface proteins which are produced by the immune system in response to the presence of a foreign substance (called antigen).
DOI: 10.1039/C5MB00883B
Published: 11 Feb 2016
31 citations
MicroRNA precursor identification is an important task in bioinformatics.
DOI: 10.1039/C5MB00050E
Published: 17 Feb 2015

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