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Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
Impact Factor 3.21 12 Issues per Year Indexed in Medline
 
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Molecular BioSystems,
01 May 2016 , Issue 5,
Page 1397 to 1712
Mol. BioSyst., 2016, 12, 1407-1419
DOI: 10.1039/C6MB00082G, Review Article
The advantages and disadvantages of different strategies of exosome isolation are discussed with special emphasis being placed on their adequacy for proteomics applications.
 
Mol. BioSyst., 2016, 12, 1420-1431
DOI: 10.1039/C5MB00550G, Review Article
From themed collection 10th Anniversary of Molecular BioSystems
Dozens of intracellular proteins have a second function on the cell surface, referred to as “intracellular/surface moonlighting proteins”. An analysis of the results of 22 cell surface proteomics studies was performed to address whether the hundreds of intracellular proteins found on the cell surface could be candidates for being additional intracellular/surface moonlighting proteins.
 
Jiantao Zhang, Chaochen Wu, Jiayuan Sheng and Xueyang Feng
Mol. BioSyst., 2016, 12, 1432-1435
DOI: 10.1039/C5MB00888C, Communication
From themed collection Chemical Biology in Molecular BioSystems
We report for the first time that 5-hydroxytryptophan can be synthesized in Saccharomyces cerevisiae by heterologously expressing prokaryotic phenylalanine 4-hydroxylase or eukaryotic tryptophan 3/5-hydroxylase, together with enhanced synthesis of MH4 or BH4 cofactors.
 
Renping Wang, Xueqin Gu, Weiquan Dai, Jun Ye, Feng Lu, Yifeng Chai, Guorong Fan, Frank J. Gonzalez, Gengli Duan and Yunpeng Qi
Mol. BioSyst., 2016, 12, 1436-1444
DOI: 10.1039/C5MB00864F, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Celastrol significantly alleviated DSS-induced colitis in mice. Lipidomics highlights alteration of several lipid markers associated with colitis. Celastrol treatment recovered SCD1 expression and restored the levels of lipid markers.
 
Mol. BioSyst., 2016, 12, 1445-1456
DOI: 10.1039/C5MB00722D, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Silencing of USP22 suppresses high glucose-induced podocyte injury.
 
Mol. BioSyst., 2016, 12, 1457-1467
DOI: 10.1039/C6MB00077K, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Plasmepsin V belongs to the plasmepsin family of aspartic proteases.
 
Mol. BioSyst., 2016, 12, 1468-1477
DOI: 10.1039/C5MB00741K, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
The proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in the formation of neurotoxic Aβ peptides, causative of neurodegeneration in Alzheimer's disease (AD).
 
Mol. BioSyst., 2016, 12, 1478-1485
DOI: 10.1039/C6MB00094K, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Ru1 and Ru2 not only can stabilize the triplex, but also can serve as molecular “light switches” for the triplex. In addition, the two complexes stabilizing third-strand is weaker, reflecting the binding of Ru1 and Ru2 with the triplex is favored by the Watson–Crick base-paired duplex.
 
Mol. BioSyst., 2016, 12, 1486-1495
DOI: 10.1039/C6MB00028B, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
A number of mathematical models of apoptosis generated recently allowed us to understand intrinsic mechanisms of life/death decisions in a cell.
 
Mol. BioSyst., 2016, 12, 1496-1506
DOI: 10.1039/C5MB00827A, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
We reconstructed hepatitis C virus assembly reactions to find host-target metabolites impeding this reaction.
 
Jillian N. Whelan, Krishna D. Reddy, Vladimir N. Uversky and Michael N. Teng
Mol. BioSyst., 2016, 12, 1507-1526
DOI: 10.1039/C6MB00122J, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
The respiratory syncytial virus proteome is highly enriched in intrinsically disordered regions, which confer many functional advantages.
 
Anastasia D. Miroshnikova, Alexandra A. Kuznetsova, Yuri N. Vorobjev, Nikita A. Kuznetsov and Olga S. Fedorova
Mol. BioSyst., 2016, 12, 1527-1539
DOI: 10.1039/C6MB00128A, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Here, we used stopped-flow fluorescence techniques to conduct a comparative kinetic analysis of the conformational transitions in human apurinic/apyrimidinic endonuclease 1 (APE1) and in DNA containing an abasic site in the course of their interaction.
 
Can Chen, Jingjing Deng, Xiaoping Yu, Fengbo Wu, Ke Men, Qian Yang, Yanfeng Zhu, Xiaogang Liu and Qinglin Jiang
Mol. BioSyst., 2016, 12, 1540-1551
DOI: 10.1039/C5MB00911A, Paper
From themed collection Chemical Biology in Molecular BioSystems
This study reveals DDR1 plays an important role in idiopathic pulmonary fibrosis and identifies a DDR1 inhibitor for possible future therapy.
 
Debby D. Wang, Victor H. F. Lee, Guangyu Zhu, Bin Zou, Lichun Ma and Hong Yan
Mol. BioSyst., 2016, 12, 1552-1563
DOI: 10.1039/C6MB00038J, Paper
The EGFR mutation-response or mutation-PFS correlation for afatinib in NSCLC treatment was computationally profiled, promoting specialized and innovative drug design.
 
A. de Almeida, A. P. Martins, A. F. Mósca, H. J. Wijma, C. Prista, G. Soveral and A. Casini
Mol. BioSyst., 2016, 12, 1564-1573
DOI: 10.1039/C6MB00013D, Paper
From themed collection Chemical Biology in Molecular BioSystems
The pH gating of human AQP3 and its effects on both water and glycerol permeabilities have been fully characterized for the first time using a human red blood cell model (hRBC).
 
Chao Zhou, Hong-mei Jia, Yue-tao Liu, Meng Yu, Xing Chang, Yuan-ming Ba and Zhong-mei Zou
Mol. BioSyst., 2016, 12, 1574-1585
DOI: 10.1039/C6MB00092D, Paper
This study first reports the metabolic variations at the early stage of the liver injury related to autoimmune hepatitis.
 
Mol. BioSyst., 2016, 12, 1586-1599
DOI: 10.1039/C6MB00031B, Paper
Illustration of the competitive pharmacology (“cation–π” vs. “π–π” interactions) operating at the “orthosteric” site2 of C5aR.
 
Michael Kenn, Reiner Ribarics, Nevena Ilieva, Michael Cibena, Rudolf Karch and Wolfgang Schreiner
Mol. BioSyst., 2016, 12, 1600-1614
DOI: 10.1039/C5MB00879D, Paper
The aim of this work is to find semi-rigid domains within large proteins as reference structures for fitting molecular dynamics trajectories.
 
Sonam Grover, Paras Gupta, Parvinderdeep S. Kahlon, Sukriti Goyal, Abhinav Grover, Kuldeep Dalal, Sabeeha, Nasreen Z. Ehtesham and Seyed E. Hasnain
Mol. BioSyst., 2016, 12, 1615-1625
DOI: 10.1039/C5MB00810G, Paper
Tuberculosis is a devastating disease, taking one human life every 20 seconds globally.
 
Zhang-Feng Zhong, Wen Tan, William W. Qiang, Virginia L. Scofield, Ke Tian, Chun-Ming Wang, Wen-An Qiang and Yi-Tao Wang
Mol. BioSyst., 2016, 12, 1626-1637
DOI: 10.1039/C6MB00003G, Paper
From themed collection Chemical Biology in Molecular BioSystems
Furanodiene is a bioactive sesquiterpene isolated from the spice-producing Curcuma wenyujin plant (Y. H. Chen and C. Ling) (C. wenyujin), which is a commonly prescribed herb used in clinical cancer therapy by modern practitioners of traditional Chinese medicine.
 
Nancy E. Witowski, Elizabeth R. Lusczek, Charles E. Determan, Daniel R. Lexcen, Kristine E. Mulier, Andrea Wolf, Beverly G. Ostrowski and Greg J. Beilman
Mol. BioSyst., 2016, 12, 1638-1652
DOI: 10.1039/C5MB00637F, Paper
Metabolomics data from four compartments in porcine polytrauma suggest differences in carbohydrate processing between survivors and non-survivors even before injury.
 
Mol. BioSyst., 2016, 12, 1653-1666
DOI: 10.1039/C6MB00052E, Paper
Illuminating the mechanisms of action of drugs used for myocardial infarction (MI) and the cardiovascular effects of non-MI drugs.
 
Mol. BioSyst., 2016, 12, 1667-1675
DOI: 10.1039/C6MB00123H, Paper
The constructed SRA, HQSAR, almond and CoMSIA models have good predictive capability, which can evaluate and screen new compounds.
 
Mol. BioSyst., 2016, 12, 1676-1686
DOI: 10.1039/C5MB00850F, Paper
The issue of what factors shape the gut microbiota has been studied for years.
 
Atanu Singha Roy, Debi Ranjan Tripathy, Sintu Samanta, Sudip K. Ghosh and Swagata Dasgupta
Mol. BioSyst., 2016, 12, 1687-1701
DOI: 10.1039/C6MB00161K, Paper
From themed collection Chemical Biology in Molecular BioSystems
The rutin–Cu(II) complex causes DNA damage and is also able to inhibit the growth of human HeLa cells. This complex binds with serum albumins via hydrophobic forces.
 

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