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Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
Impact Factor 3.21 12 Issues per Year Indexed in Medline
 
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Molecular BioSystems,
01 June 2016 , Issue 6,
Page 1713 to 2012
Lyn H. Jones and Eranthie Weerapana
Mol. BioSyst., 2016, 12, 1725-1727
DOI: 10.1039/C6MB90019D, Editorial
From themed collection Protein Labelling
Professor Eranthie Weerapana and Professor Lyn Jones introduce this Protein Labelling themed issue.
 
Mol. BioSyst., 2016, 12, 1728-1730
DOI: 10.1039/C5MB00760G, Opinion
From themed collection Chemical Biology in Molecular BioSystems
The reactivity of amino acid residues in proteins is context-dependent and difficult to predict.
 
Jonathan Lotze, Ulrike Reinhardt, Oliver Seitz and Annette G. Beck-Sickinger
Mol. BioSyst., 2016, 12, 1731-1745
DOI: 10.1039/C6MB00023A, Review Article
From themed collection Chemical Biology in Molecular BioSystems
Peptide-tag based labelling can be achieved by (i) enzymes (ii) recognition of metal ions or small molecules and (iii) peptide–peptide interactions and enables site-specific protein visualization to investigate protein localization and trafficking.
 
Yunan Zheng, Marc J. Lajoie, James S. Italia, Melissa A. Chin, George M. Church and Abhishek Chatterjee
Mol. BioSyst., 2016, 12, 1746-1749
DOI: 10.1039/C6MB00070C, Communication
From themed collection Chemical Biology in Molecular BioSystems
Unconditional deletion of RF1 in a genomically recoded E. coli enables multisite noncanonical amino acid incorporation by UAG suppression.
 
E. Hoffmann, K. Streichert, N. Nischan, C. Seitz, T. Brunner, S. Schwagerus, C. P. R. Hackenberger and M. Rubini
Mol. BioSyst., 2016, 12, 1750-1755
DOI: 10.1039/C5MB00857C, Communication
From themed collection Chemical Biology in Molecular BioSystems
Erythropoietin (EPO) with single small branched PEG chains installed by the Staudinger-phosphite reaction leads to enhanced solubility, stability and intact in vitro bioactivity.
 
Matthew E. Griffin, Elizabeth H. Jensen, Daniel E. Mason, Courtney L. Jenkins, Shannon E. Stone, Eric C. Peters and Linda C. Hsieh-Wilson
Mol. BioSyst., 2016, 12, 1756-1759
DOI: 10.1039/C6MB00138F, Communication
From themed collection 2016 Hot Articles in Molecular BioSystems
A novel approach utilizing a chemically cleavable Dde-based tag is employed herein to quantitatively label and release O-GlcNAcylated proteins for the mass spectrometric identification of previously unknown glycosylation sites.
 
A. Ivona Petrache, Darren C. Machin, Daniel J. Williamson, Michael E. Webb and Paul A. Beales
Mol. BioSyst., 2016, 12, 1760-1763
DOI: 10.1039/C6MB00126B, Communication
From themed collection Chemical Biology in Molecular BioSystems
Lipid nanodiscs have broad applications in membrane protein assays, biotechnology and materials science.
 
Mol. BioSyst., 2016, 12, 1764-1767
DOI: 10.1039/C6MB00165C, Communication
From themed collection Chemical Biology in Molecular BioSystems
SUMO-fused and intein-fused protein expression systems have been combined to prepare a dual-color labeled ubiquitin sensor for detecting UCH-L3's activity.
 
Mol. BioSyst., 2016, 12, 1768-1771
DOI: 10.1039/C6MB00250A, Communication
From themed collection Chemical Biology in Molecular BioSystems
Glutathione S-transferase Pi (GSTP1) mediates cellular defense against reactive electrophiles.
 
Mol. BioSyst., 2016, 12, 1772-1780
DOI: 10.1039/C6MB00024J, Paper
From themed collection Chemical Biology in Molecular BioSystems
Synthesis and use of benzimidazole activity-based probes to validate target labeling and identify novel binding partners.
 
Victoria E. Albrow, Rachel L. Grimley, James Clulow, Colin R. Rose, Jianmin Sun, Joseph S. Warmus, Edward W. Tate, Lyn H. Jones and R. Ian Storer
Mol. BioSyst., 2016, 12, 1781-1789
DOI: 10.1039/C6MB00109B, Paper
From themed collection Chemical Biology in Molecular BioSystems
Validation of novel chemical probes containing photoreactive crosslinking groups and biotin or click reporters is reported for the proteomic study of HDAC complexes.
 
Mol. BioSyst., 2016, 12, 1790-1798
DOI: 10.1039/C5MB00847F, Paper
From themed collection Chemical Biology in Molecular BioSystems
We report a simplified immunochemical approach to directly detect and quantify oxidized protein tyrosine phosphatases modified with dimedone.
 
Jeannie L. Hernandez, Dahvid Davda, Jaimeen D. Majmudar, Sang Joon Won, Ashesh Prakash, Alexandria I. Choi and Brent R. Martin
Mol. BioSyst., 2016, 12, 1799-1808
DOI: 10.1039/C6MB00019C, Paper
From themed collection Chemical Biology in Molecular BioSystems
Over-expression of the mesenchymal transcription factor Snail alters expression of many proteins. These changes are largely correlated with changes in S-palmitoylation, but in some cases are uncoupled.
 
Sara C. Stolze, Nora Liu, Ruud H. Wijdeven, Adriaan W. Tuin, Adrianus M. C. H. van den Nieuwendijk, Bogdan I. Florea, Mario van der Stelt, Gijsbert A. van der Marel, Jacques J. Neefjes and Herman S. Overkleeft
Mol. BioSyst., 2016, 12, 1809-1817
DOI: 10.1039/C6MB00257A, Paper
From themed collection Chemical Biology in Molecular BioSystems
H89-derived photo-affinity probes can be used to label clinically relevant kinases as well as to screen known and identify novel kinase inhibitors.
 
Bahareh Rabbani, Hirofumi Nakaoka, Shahin Akhondzadeh, Mustafa Tekin and Nejat Mahdieh
Mol. BioSyst., 2016, 12, 1818-1830
DOI: 10.1039/C6MB00115G, Review Article
A breakthrough in next generation sequencing (NGS) in the last decade provided an unprecedented opportunity to investigate genetic variations in humans and their roles in health and disease.
 
Mol. BioSyst., 2016, 12, 1831-1841
DOI: 10.1039/C6MB00137H, Paper
Stroke is one of the most fatal diseases in the world, which is seriously threatening human life.
 
Marwa Eltoweissy, Gry H. Dihazi, Gerhard A. Müller, Abdul R. Asif and Hassan Dihazi
Mol. BioSyst., 2016, 12, 1842-1859
DOI: 10.1039/C5MB00887E, Paper
From themed collection Chemical Biology in Molecular BioSystems
In the pathogenesis of renal fibrosis, oxidative stress (OS) enhances the production of reactive oxygen species (ROS) leading to sustained cell growth, inflammation, excessive tissue remodelling and accumulation, which results in the development and acceleration of renal damage.
 
Liang-chao Zhao, Bai-yong Shen, Xia-xing Deng, Hao Chen, Zheng-gang Zhu and Cheng-hong Peng
Mol. BioSyst., 2016, 12, 1860-1870
DOI: 10.1039/C6MB00203J, Paper
From themed collection Chemical Biology in Molecular BioSystems
Silencing of TMEM45B induces apoptosis and suppresses invasion and migration in pancreatic cancer cells.
 
Mehboob Hoque, Jyoti Gupta, Gulam Rabbani, Rizwan Hasan Khan and M. Saleemuddin
Mol. BioSyst., 2016, 12, 1871-1880
DOI: 10.1039/C5MB00905G, Paper
From themed collection Chemical Biology in Molecular BioSystems
Oleic acid (OA) complexes of human alpha-lactalbumin (α-LA) and several other proteins are effective in the killing of a variety of tumor cells.
 
Mol. BioSyst., 2016, 12, 1881-1891
DOI: 10.1039/C6MB00228E, Paper
From themed collection Chemical Biology in Molecular BioSystems
Computational analyses revealed correlations between the intrinsic disorder propensity of shell proteins and case fatality rates (CFRs) among Flaviviruses and within at least two Flavivirus species, such as tick-borne encephalitis virus (TBEV) and dengue virus (DENV).
 
Mol. BioSyst., 2016, 12, 1892-1900
DOI: 10.1039/C6MB00160B, Paper
From themed collection Chemical Biology in Molecular BioSystems
Guanine(C8)–thymine(N3) intrastrand cross-links are bypassed with varying efficiencies by Y-family polymerases, but the A-family polymerase BF is strongly blocked.
 
Mol. BioSyst., 2016, 12, 1901-1912
DOI: 10.1039/C6MB00263C, Paper
When exposed to low concentrations of toxic chemicals, bacteria modulate the expression of a number of cellular processes.
 
Junhao Li, Hanwen Du, Zengrui Wu, Haixia Su, Guixia Liu, Yun Tang and Weihua Li
Mol. BioSyst., 2016, 12, 1913-1921
DOI: 10.1039/C6MB00139D, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Cytochrome P450 2C19 (CYP2C19) is one of 57 drug metabolizing enzymes in humans and is responsible for the metabolism of ∼7–10% of drugs in clinical use.
 
Mol. BioSyst., 2016, 12, 1922-1928
DOI: 10.1039/C6MB00118A, Paper
Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary cancer complex syndrome manifesting a variety of endocrine and non-endocrine neoplasms and lesions.
 
Mol. BioSyst., 2016, 12, 1929-1937
DOI: 10.1039/C6MB00009F, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Analyzing isotopes in multiple elements of metabolites can shed light on the coordination of carbon and nitrogen metabolism.
 

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