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Journal cover: Molecular BioSystems

Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.
Impact Factor 3.183 12 Issues per Year Indexed in Medline
 
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Molecular BioSystems,
01 May 2015 , Issue 5,
Page 1207 to 1474
Mol. BioSyst., 2015, 11, 1217-1234
DOI: 10.1039/C5MB00064E, Review Article
Composite biomarkers of beta-cell injury (miRNAs, autoantibodies, or cytokines) may lead to better biomarkers of diabetes.
 
Mol. BioSyst., 2015, 11, 1235-1240
DOI: 10.1039/C4MB00711E, Method
Reference gene-based normalization of expression profiles secures consistent differential expression analysis between samples of different phenotypes or biological conditions, and facilitates comparison between experimental batches.
 
Yali Li, Ling Wang, Zhihong Liu, Chanjuan Li, Jiake Xu, Qiong Gu and Jun Xu
Mol. BioSyst., 2015, 11, 1241-1250
DOI: 10.1039/C4MB00718B, Paper
The classification models for predicting selective LXRβ agonists were firstly established using multiple machine learning methods. The top models can predict selective LXRβ agonists with chemical structure diversity.
 
Mol. BioSyst., 2015, 11, 1251-1259
DOI: 10.1039/C4MB00713A, Paper
Computational structural biology and simulations help to understand the functional mechanism of transport proteins in Leishmaniasis.
 
Ida C. Elle, Kasper K. Karlsen, Mikkel G. Terp, Niels Larsen, Ronni Nielsen, Nicola Derbyshire, Susanne Mandrup, Henrik J. Ditzel and Jesper Wengel
Mol. BioSyst., 2015, 11, 1260-1270
DOI: 10.1039/C5MB00045A, Paper
From themed collection 2015 Hot Articles
Aptamers containing LNA nucleotides were selected against recombinant human CD73 using SELEX and next generation sequencing (NGS) with custom NGS bioinformatics software (BION-apta).
 
Chunlong Zhang, Chunquan Li, Yanjun Xu, Li Feng, Desi Shang, Xinmiao Yang, Junwei Han, Zeguo Sun, Yixue Li and Xia Li
Mol. BioSyst., 2015, 11, 1271-1284
DOI: 10.1039/C5MB00061K, Paper
From themed collection 2015 Hot Articles
Integrative analysis of lung development–cancer expression patterns reveals that proliferation and immunity were involved in the inverse expression patterns.
 
Mol. BioSyst., 2015, 11, 1285-1289
DOI: 10.1039/C5MB00127G, Paper
From themed collection 2015 Hot Articles
We provided a platform for constructing artificial microRNAs that can silence both protein-coding genes and non-coding genes.
 
Yuya Takeshige, Yoko Egami, Toshiyuki Wakimoto and Ikuro Abe
Mol. BioSyst., 2015, 11, 1290-1294
DOI: 10.1039/C5MB00131E, Paper
From themed collection 2015 Hot Articles
Sponge metagenomes are accessible genetic sources containing genes and gene clusters responsible for the biosynthesis of sponge-derived bioactive natural products.
 
Ting Ran, Zhimin Zhang, Kejun Liu, Yi Lu, Huifang Li, Jinxing Xu, Xiao Xiong, Yanmin Zhang, Anyang Xu, Shuai Lu, Haichun Liu, Tao Lu and Yadong Chen
Mol. BioSyst., 2015, 11, 1295-1304
DOI: 10.1039/C4MB00723A, Paper
The interaction mechanism of bromodomain inhibitors was investigated using interaction fingerprinting and binding free energy based methods.
 
Mol. BioSyst., 2015, 11, 1305-1318
DOI: 10.1039/C5MB00137D, Paper
Farnesoid X receptor and Takeda G-protein-coupled receptor-5 are well known bile acid receptors and act as promising targets for the drug development and treatment of diabetes.
 
Tingting Shao, Zheng Zhao, Aiwei Wu, Jing Bai, Yongsheng Li, Hong Chen, Chunjie Jiang, Yuan Wang, Shengli Li, Letian Wang, Fengmin Zhang, Juan Xu and Xia Li
Mol. BioSyst., 2015, 11, 1319-1328
DOI: 10.1039/C5MB00095E, Paper
Systematically deciphering the characteristics of crosstalk mediated by viral and human miRNAs.
 
Xueqin Gu, Yunlong Song, Yifeng Chai, Feng Lu, Frank J. Gonzalez, Guorong Fan and Yunpeng Qi
Mol. BioSyst., 2015, 11, 1329-1337
DOI: 10.1039/C5MB00048C, Paper
GC-MS metabolomics revealed discriminating metabolites in serum and colon of colitis mice to decipher the PPARα-dependent exacerbation of colitis.
 
Mol. BioSyst., 2015, 11, 1338-1347
DOI: 10.1039/C4MB00722K, Paper
The prototypical hydrolyzable tannin, pentagalloylglucose (PGG), inhibits formation of AGEs at all stages of glycation and protects protein structure.
 
Goran Jovanovic, Xia Sheng, Angelique Ale, Elisenda Feliu, Heather A. Harrington, Paul Kirk, Carsten Wiuf, Martin Buck and Michael P. H. Stumpf
Mol. BioSyst., 2015, 11, 1348-1359
DOI: 10.1039/C4MB00720D, Paper
Two-component systems play a central part in bacterial signal transduction.
 
Lei Yang, Dapeng Hao, Jizhe Wang, Xudong Xing, Yingli Lv, Yongchun Zuo and Wei Jiang
Mol. BioSyst., 2015, 11, 1360-1369
DOI: 10.1039/C5MB00124B, Paper
Acquiring comprehensive knowledge of protein in various subcellular localizations is one of the fundamental goals in cell biology and proteomics.
 
Vishnya Stoyanova, Vanya Bogoeva, Lidiya Petrova, Magdalena Tchorbadjieva, Svetla Petrova, Ventsislava Georgieva, George Georgiev, Boriana Deliyska, Vasil Vasilev and Ivanka Tsacheva
Mol. BioSyst., 2015, 11, 1370-1377
DOI: 10.1039/C5MB00021A, Paper
We analyzed the structural features of C1q that underlie its autoantigenicity by the means of a model system using an amphiphilic polyzwitterion (PZ).
 
Mol. BioSyst., 2015, 11, 1378-1388
DOI: 10.1039/C5MB00132C, Paper
From themed collection 2015 Hot Articles
The relationships among the types of transcripts, the classes of coding SNPs and the population frequencies in the human genome.
 
Rituparna Borah, Narsimha Mamidi, Subhankar Panda, Sukhamoy Gorai, Suraj Kumar Pathak and Debasis Manna
Mol. BioSyst., 2015, 11, 1389-1399
DOI: 10.1039/C5MB00100E, Paper
Investigation of γ-hydroxymethyl-γ-butyrolactone substituents as protein kinase C ligands, in an effort to develop small molecule-based regulators with higher specificity for C1 domain than the endogenous ligand, diacylglycerols.
 
QingMing Kong, QunBo Tong, Di Lou, JianZu Ding, Bin Zheng, Rui Chen, Xiao Zhu, XiaoHeng Chen, KeWei Dong and ShaoHong Lu
Mol. BioSyst., 2015, 11, 1400-1409
DOI: 10.1039/C5MB00074B, Paper
We applied isobaric tagging reagents for relative and absolute quantification analyses to investigate the effect of artesunate on the proteome of Schistosoma japonicum in susceptible mice.
 
Sourav Roy, Tarak Karmakar, Vasudeva S. Prahlada Rao, Lakshmeesha K. Nagappa, Sundaram Balasubramanian and Hemalatha Balaram
Mol. BioSyst., 2015, 11, 1410-1424
DOI: 10.1039/C5MB00136F, Paper
Coupled events of ligand-induced isomerization and oligomerization in catalysis by PfHGXPRT.
 
Yongxia Yang, Yaling Wang, Jingli Zhang, Zhihui Han, Ali Chen, Sina Pan, Shengwang Liang and Shumei Wang
Mol. BioSyst., 2015, 11, 1425-1433
DOI: 10.1039/C5MB00033E, Paper
The metabolic pathways in plasma and urine revealed the biochemical changes under chronic cold stress from a systematic and holistic view.
 
Mol. BioSyst., 2015, 11, 1434-1442
DOI: 10.1039/C4MB00600C, Paper
This study represented the first attempt to investigate the global regulation of CsrA through transcriptome analysis in Gram-positive bacteria.
 
Mol. BioSyst., 2015, 11, 1443-1453
DOI: 10.1039/C4MB00689E, Paper
The loss of a key hydrogen bond between H1 and H3 causes marked changes in the structure and dynamical behavior of PrPC.
 
Mol. BioSyst., 2015, 11, 1454-1461
DOI: 10.1039/C5MB00102A, Paper
From themed collection 2015 Hot Articles
An adenosine analog devoid of the N3-nitrogen of the purine ring was incorporated into the catalytic cores of the well-known DNA enzymes 8–17 and 10–23. The results show that minor groove interactions are important for the catalytic activity and thus constitute an important feature of DNA enzymes.
 
Reinald Shyti, Isabelle Kohler, Bart Schoenmaker, Rico J. E. Derks, Michel D. Ferrari, Else A. Tolner, Oleg A. Mayboroda and Arn M. J. M. van den Maagdenberg
Mol. BioSyst., 2015, 11, 1462-1471
DOI: 10.1039/C5MB00049A, Paper
Cortical spreading depression-induced brain metabolic changes have been captured in the plasma of a transgenic migraine mouse model using CE-MS.
 

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