Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
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Molecular BioSystems,
01 December 2016 , Issue 12,
Page 3505 to 3746
Mol. BioSyst., 2016, 12, 3515-3529
DOI: 10.1039/C6MB00598E, Review Article
This review highlights the molecular pathogenesis of Huntington's disease emphasizing how chromosome condensation defects and DNA damage may cause neural degeneration.
Vera Oldrati, Miriam Arrell, Aude Violette, Frédéric Perret, Xavier Sprüngli, Jean-Luc Wolfender and Reto Stöcklin
Mol. BioSyst., 2016, 12, 3530-3543
DOI: 10.1039/C6MB00516K, Review Article
The term “venomics” was coined to describe the global study of venom and venom glands, targeting comprehensive characterization of the whole toxin profile of a venomous animal by means of proteomics, transcriptomics, genomics and bioinformatics studies.
Rui Hu, Hong-Kin Yap, Yik-Hong Fung, Yong Wang, Wing-Lam Cheong, Lok-Yan So, Chui-Shan Tsang, Lawrence Yoon Suk Lee, Warrick Ken Cheung Lo, Jian Yuan, Ning Sun, Yun-Chung Leung, Guoqiang Yang and Kwok-Yin Wong
Mol. BioSyst., 2016, 12, 3544-3549
DOI: 10.1039/C6MB00566G, Communication
Aggregation induced emissive compound EPB can detect protein–protein interaction.
Mol. BioSyst., 2016, 12, 3550-3555
DOI: 10.1039/C6MB00659K, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
We have developed an exonuclease and nicking endonuclease aided electrochemical biosensor for the isothermal amplification detection of miRNA.
Mol. BioSyst., 2016, 12, 3556-3566
DOI: 10.1039/C6MB00573J, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Monoclonal light chain (NGTA1-Me-pro) possessing two alternative active centers with metalloprotease activities specifically recognizing only myelin basic protein (MBP) was obtained. NGTA1-Me-pro demonstrated two pH optima (A), two optimal concentrations of Me2+ ions (B), and two Km values for MBP.
Mol. BioSyst., 2016, 12, 3567-3575
DOI: 10.1039/C6MB00608F, Paper
Distribution of organic compounds between different biological tissues may be considered in the framework of solute partitioning in aqueous two-phase systems.
Mol. BioSyst., 2016, 12, 3576-3588
DOI: 10.1039/C6MB00235H, Paper
Spectroscopic studies of human H-type ferritin in comparison with an archaeal ferritin from Pyrococcus furiosus reveal how kinetics of a common mechanism of Fe(II) oxidation is tuned differently in these two ferritins.
Mol. BioSyst., 2016, 12, 3589-3599
DOI: 10.1039/C6MB00606J, Paper
Stiffness of disordered linkers affects the conformation of the active-site cleft when Cel8A is bound to its substrate.
Matthias G. Beuerle, Neil P. Dufton, Anna M. Randi and Ian R. Gould
Mol. BioSyst., 2016, 12, 3600-3610
DOI: 10.1039/C6MB00506C, Paper
Molecular dynamics study elucidating the mechanistic background of the DNA-binding process and the sequence specificity of the transcription factor ERG. Along with the biological findings the capabilities of unbiased DNA-binding simulations in combination with various means of analysis in the field of protein DNA-interactions are shown.
Sung Hyeon Lee, Seunghyup Jeong, Jua Lee, In Seok Yeo, Myung Jin Oh, Unyong Kim, Sumin Kim, Su Hee Kim, Seung-Yeol Park, Jae-Han Kim, Se Hoon Park, Jung Hoe Kim and Hyun Joo An
Mol. BioSyst., 2016, 12, 3611-3621
DOI: 10.1039/C6MB00559D, Paper
A newly developed platform demonstrates quantitative, structure-specific profiling of haptoglobin glycosylation for the purpose of biomarker discovery for gastric cancer.
Soujanya D. Yelamanchi, Manish Kumar, Anil K. Madugundu, Lathika Gopalakrishnan, Gourav Dey, Sandip Chavan, Gajanan Sathe, Premendu P. Mathur, Harsha Gowda, Anita Mahadevan, Susarla K. Shankar and T. S. Keshava Prasad
Mol. BioSyst., 2016, 12, 3622-3632
DOI: 10.1039/C6MB00507A, Paper
We employed a high-resolution mass spectrometry-based approach to characterize the proteome of the human pineal gland.
Kamalika Sen, Arijita Sarkar, Ranjan Kumar Maji, Zhumur Ghosh, Sanjib Gupta and Tapash Chandra Ghosh
Mol. BioSyst., 2016, 12, 3633-3642
DOI: 10.1039/C6MB00568C, Paper
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by increased proliferation or abnormal accumulation of the granulocytic cell line without the depletion of their capacity to differentiate.
Mol. BioSyst., 2016, 12, 3643-3650
DOI: 10.1039/C6MB00626D, Paper
A dynamic query-driven learning scheme helps to make more use of proteins with known structure and functions.
Daniel Ian McSkimming, Shima Dastgheib, Timothy R. Baffi, Dominic P. Byrne, Samantha Ferries, Steven Thomas Scott, Alexandra C. Newton, Claire E. Eyers, Krzysztof J. Kochut, Patrick A. Eyers and Natarajan Kannan
Mol. BioSyst., 2016, 12, 3651-3665
DOI: 10.1039/C6MB00466K, Paper
KinView enables both experts and novices to perform comparative analyses of cancer variants in the context of natural sequence variation and post-translational modifications across evolutionary groups of kinases.
Arthitaya Meeprasert, Supot Hannongbua, Nawee Kungwan and Thanyada Rungrotmongkol
Mol. BioSyst., 2016, 12, 3666-3673
DOI: 10.1039/C6MB00610H, Paper
Disrupted hydrogen bonding network in the extended S2 subsite lead to faldaprevir and danoprevir resistances.
Ronald Zielman, Rudmer Postma, Aswin Verhoeven, Floor Bakels, Willebrordus P. J. van Oosterhout, Axel Meissner, Arn M. J. M. van den Maagdenberg, Gisela M. Terwindt, Oleg A. Mayboroda and Michel D. Ferrari
Mol. BioSyst., 2016, 12, 3674-3682
DOI: 10.1039/C6MB00424E, Paper
Hemiplegic migraine patients can be discriminated from healthy controls, with 2-hydroxybutyrate and 2-hydroxyisovalerate as the most discriminant metabolites.
Jeganathan Manivannan, Manjunath Prashanth, Venkatesan Saravana Kumar, Manickaraj Shairam and Jayachandran Subburaj
Mol. BioSyst., 2016, 12, 3683-3694
DOI: 10.1039/C6MB00557H, Paper
Transcriptomics data reanalysis explores novel mechanisms behind vascular calcification events and provides clues for novel therapeutic strategies.
Amanda L. Mansouri, Laura N. Grese, Erica L. Rowe, James C. Pino, S. Chakra Chennubhotla, Arvind Ramanathan, Hugh M. O'Neill, Valerie Berthelier and Christopher B. Stanley
Mol. BioSyst., 2016, 12, 3695-3701
DOI: 10.1039/C6MB00512H, Paper
Preferential hydration changes accompanying the osmotic folding of two intrinsically disordered proteins (IDPs) were determined.
Ji-Yong An, Zhu-Hong You, Xing Chen, De-Shuang Huang, Guiying Yan and Da-Fu Wang
Mol. BioSyst., 2016, 12, 3702-3710
DOI: 10.1039/C6MB00599C, Paper
Self-interacting proteins (SIPs) play an essential role in cellular functions and the evolution of protein interaction networks (PINs).
Nidhi Singh, Priyanka Shah, Hemlata Dwivedi, Shikha Mishra, Renu Tripathi, Amogh A. Sahasrabuddhe and Mohammad Imran Siddiqi
Mol. BioSyst., 2016, 12, 3711-3723
DOI: 10.1039/C6MB00574H, Paper
Integrated in silico approaches for the identification of antitrypanosomal inhibitors.
Mol. BioSyst., 2016, 12, 3724-3733
DOI: 10.1039/C6MB00617E, Paper
Biological networks are effective tools for studying molecular interactions.
Mol. BioSyst., 2016, 12, 3734-3742
DOI: 10.1039/C6MB00661B, Paper
Novel AChE inhibitors are discovered using computer aided drug design and bioassays.
Oveis Jamialahmadi, Ehsan Motamedian and Sameereh Hashemi-Najafabadi
Mol. BioSyst., 2016, 12, 3743-3743
DOI: 10.1039/C6MB90040B, Correction

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49 citations
With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent to develop automated methods for analyzing the relationship between the sequences and their functions.
DOI: 10.1039/C5MB00155B
Published: 05 Jun 2015
13 citations
Immunoglobulins, also called antibodies, are a group of cell surface proteins which are produced by the immune system in response to the presence of a foreign substance (called antigen).
DOI: 10.1039/C5MB00883B
Published: 11 Feb 2016
31 citations
MicroRNA precursor identification is an important task in bioinformatics.
DOI: 10.1039/C5MB00050E
Published: 17 Feb 2015

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