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Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
 
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Molecular BioSystems,
01 February 2017 , Issue 2,
Page 227 to 434
Kunihiko Morihiro, Yuuya Kasahara and Satoshi Obika
Mol. BioSyst., 2017, 13, 235-245
DOI: 10.1039/C6MB00538A, Review Article
Xeno nucleic acids (XNAs) are a group of chemically modified nucleic acid analogues that have been applied to various biological technologies such as antisense oligonucleotides, siRNAs and aptamers.
 
Nikolas Ferreira dos Santos Paparidis, Maxwell Castro Durvale and Fernanda Canduri
Mol. BioSyst., 2017, 13, 246-276
DOI: 10.1039/C6MB00387G, Review Article
From themed collection 2017 Hot Articles in Molecular Biosystems
CDK9 is a prominent member of the transcriptional CDKs subfamily, a group of kinases whose function is to control the primary steps of mRNA synthesis and processing by eukaryotic RNA polymerase II.
 
M. Baranek, A. Belter, M. Z. Naskręt-Barciszewska, M. Stobiecki, W. T. Markiewicz and J. Barciszewski
Mol. BioSyst., 2017, 13, 277-313
DOI: 10.1039/C6MB00595K, Review Article
Small molecules cause pluripotency induction through epigenetic changes such as DNA methylation, histone modifications, RNA noncoding and chromatin remodeling.
 
Mol. BioSyst., 2017, 13, 314-319
DOI: 10.1039/C6MB00748A, Communication
We rationally designed a novel regulation-type of artificial riboswitch that upregulates the 3′ CITE-mediated translation in response to a specific ligand without major hybridization switches in a plant expression system.
 
Aihua Zhang, Xiaohang Zhou, Hongwei Zhao, Shiyu Zou, Chung Wah Ma, Qi Liu, Hui Sun, Liang Liu and Xijun Wang
Mol. BioSyst., 2017, 13, 320-329
DOI: 10.1039/C6MB00677A, Communication
An integrative metabolomics and proteomics approach can provide novel insights in the understanding of biological systems.
 
Mol. BioSyst., 2017, 13, 330-337
DOI: 10.1039/C6MB00678G, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Small-molecule marine natural products are identified to selectively recognize and stabilize the DNA-binding conformation of FOXO1, an oncogenic transcription factor.
 
Lu Sun, Liang Fang, Bin Lian, Jin-Jun Xia, Chan-juan Zhou, Ling Wang, Qiang Mao, Xin-Fa Wang, Xue Gong, Zi-Hong Liang, Shun-Jie Bai, Li Liao, Yu Wu and Peng Xie
Mol. BioSyst., 2017, 13, 338-349
DOI: 10.1039/C6MB00651E, Paper
From themed collection 2017 Hot Articles in Molecular Biosystems
As a serotonin–norepinephrine reuptake inhibitor [SNRI], venlafaxine is one of the most commonly prescribed clinical antidepressants, with a broad range of antidepressant effects.
 
Md. Zubbair Malik, Md. Jahoor Alam, Romana Ishrat, Subhash M. Agarwal and R. K. Brojen Singh
Mol. BioSyst., 2017, 13, 350-362
DOI: 10.1039/C6MB00525J, Paper
The nuclear matrix associated protein SMAR1 is sensitive to p53 and acts as a stress inducer as well as a regulator in the p53 regulatory network.
 
Yinglan Pu, Shuqun Zhang, Zhe Chang, Yunqin Zhang, Dong Wang, Li Zhang, Yan Li and Zhili Zuo
Mol. BioSyst., 2017, 13, 363-370
DOI: 10.1039/C6MB00712K, Paper
Discovery of novel dual site TNKS inhibitors by pharmacophore modeling, molecular docking and bioassay.
 
Mol. BioSyst., 2017, 13, 371-379
DOI: 10.1039/C6MB00600K, Paper
This work exposes disturbances in major metabolic pathways while providing a prospective path both for diagnosis and underlying ME/CFS/SEID mechanisms.
 
Zichuang Yan, Yongjing Liu, Yunzhen Wei, Ning Zhao, Qiang Zhang, Cheng Wu, Zhiqiang Chang and Yan Xu
Mol. BioSyst., 2017, 13, 380-391
DOI: 10.1039/C6MB00625F, Paper
Copy number alteration (CNA) represents an important class of genetic variations that may contribute to tumorigenesis, tumor growth and metastatic spread.
 
Cristian Piras, Yongzhi Guo, Alessio Soggiu, Metasu Chanrot, Viviana Greco, Andrea Urbani, Gilles Charpigny, Luigi Bonizzi, Paola Roncada and Patrice Humblot
Mol. BioSyst., 2017, 13, 392-405
DOI: 10.1039/C6MB00723F, Paper
Proteomics of the physiological response of bEECs to LPS challenge to unravel the possible implication of bacterial infection in pregnancy establishment.
 
Mol. BioSyst., 2017, 13, 406-416
DOI: 10.1039/C6MB00807K, Paper
In the present work, latest network pharmacological approach has been used for the screening of natural anticancer compounds from Clerodendrum species.
 
Mol. BioSyst., 2017, 13, 417-424
DOI: 10.1039/C6MB00744A, Paper
The RF and pharmacophore models can be considered as integrated screening tools to indicate the potential risk of cholestatic DILI.
 
Mingyuan Xin, Jun Fan, Mingyao Liu and Zhenran Jiang
Mol. BioSyst., 2017, 13, 425-431
DOI: 10.1039/C6MB00635C, Paper
Identifying drug modes of action (MoA) is of paramount importance for having a good grasp of drug indications in clinical tests.
 
Kienana Muhrez, Lydie Nadal-Desbarats, Jean-Michel Halimi, Binta Dieme, Matthias Büchler, Patrick Emond, Hélène Blasco and Chantal Le Guellec
Mol. BioSyst., 2017, 13, 432-432
DOI: 10.1039/C7MB90005H, Correction
 

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55 citations
With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent to develop automated methods for analyzing the relationship between the sequences and their functions.
DOI: 10.1039/C5MB00155B
Published: 05 Jun 2015
16 citations
Immunoglobulins, also called antibodies, are a group of cell surface proteins which are produced by the immune system in response to the presence of a foreign substance (called antigen).
DOI: 10.1039/C5MB00883B
Published: 11 Feb 2016
31 citations
MicroRNA precursor identification is an important task in bioinformatics.
DOI: 10.1039/C5MB00050E
Published: 17 Feb 2015

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