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Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
Impact Factor 3.21 12 Issues per Year Indexed in Medline
 
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Molecular BioSystems,
01 August 2015 , Issue 8,
Page 2105 to 2384
Marie Schrynemackers, Louis Wehenkel, M. Madan Babu and Pierre Geurts
Mol. BioSyst., 2015, 11, 2116-2125
DOI: 10.1039/C5MB00174A, Method
We systematically investigate, theoretically and empirically, the application of tree-based methods for the supervised inference of biological networks.
 
Raheleh Amirkhah, Ali Farazmand, Shailendra K. Gupta, Hamed Ahmadi, Olaf Wolkenhauer and Ulf Schmitz
Mol. BioSyst., 2015, 11, 2126-2134
DOI: 10.1039/C5MB00245A, Method
The article describes a novel method (CRCmiRTar) for a CRC-specific prediction of functional miRNA-target interactions based on a machine learning approach.
 
Trayambak Basak, Ajay Bhat, Dipankar Malakar, Manoj Pillai and Shantanu Sengupta
Mol. BioSyst., 2015, 11, 2135-2143
DOI: 10.1039/C5MB00234F, Paper
SWATH is capable of quantifying proteins of lower abundance as compared to iTRAQ.
 
Mol. BioSyst., 2015, 11, 2144-2151
DOI: 10.1039/C5MB00206K, Paper
From themed collection 2015 Hot Articles in Molecular BioSystems
D/E-rich proteins might be involved in DNA mimicry, mRNA processing and regulation of the transcription complex.
 
Mol. BioSyst., 2015, 11, 2152-2157
DOI: 10.1039/C5MB00348B, Paper
From themed collection Chemical Biology in Molecular BioSystems
Ligands binding significantly affect protein flexibility and dynamics.
 
Liang Liu, Hongyan Wang, Jianguo Wen, Chih-En Tseng, Youli Zu, Chung-che Chang and Xiaobo Zhou
Mol. BioSyst., 2015, 11, 2158-2166
DOI: 10.1039/C4MB00663A, Paper
Myelodysplastic syndromes are a heterogeneous group of clonal disorders of hematopoietic progenitors and have potentiality to progress into acute myelogenous leukemia.
 
L. Michel Espinoza-Fonseca, Lorenzo Alamo, Antonio Pinto, David D. Thomas and Raúl Padrón
Mol. BioSyst., 2015, 11, 2167-2179
DOI: 10.1039/C5MB00162E, Paper
From themed collection Chemical Biology in Molecular BioSystems
Tarantula thick filament activation is triggered by disorder-to-order transition in myosin regulatory light chain N-terminal extension controlled by sequential phosphorylation.
 
Lorenzo Alamo, Xiaochuan (Edward) Li, L. Michel Espinoza-Fonseca, Antonio Pinto, David D. Thomas, William Lehman and Raúl Padrón
Mol. BioSyst., 2015, 11, 2180-2189
DOI: 10.1039/C5MB00163C, Paper
From themed collection Chemical Biology in Molecular BioSystems
Tarantula thick filament activation stiffens myosin regulatory light chain N-terminal extension by sequential phosphorylation hindering the docking back of the free head.
 
Wolfgang Schmidt-Heck, Madlen Matz-Soja, Susanne Aleithe, Eugenia Marbach, Reinhard Guthke and Rolf Gebhardt
Mol. BioSyst., 2015, 11, 2190-2197
DOI: 10.1039/C5MB00129C, Paper
The Hedgehog signalling-driven Gli transcription factors in hepatocytes form a regulatory network identified by a fuzzy-logic modelling approach. The network explains dynamic features important for hepatocyte function and fate.
 
Katherine A. Hollywood, Catherine L. Winder, Warwick B. Dunn, Yun Xu, David Broadhurst, Christopher E. M. Griffiths and Royston Goodacre
Mol. BioSyst., 2015, 11, 2198-2209
DOI: 10.1039/C4MB00739E, Paper
GC-MS-based metabolomics illustrates the response of central metabolism metabolites upon treatment with the anti-psoriatic drug dithranol.
 
Mol. BioSyst., 2015, 11, 2210-2218
DOI: 10.1039/C5MB00273G, Paper
One can suggest that the repeats in prion-like domains of RNA-binding proteins assist in the rapid initiation of the process of assembly and formation of cross-β structures and such domains most likely should be disordered.
 
Mol. BioSyst., 2015, 11, 2219-2226
DOI: 10.1039/C5MB00214A, Paper
PredcircRNA presents computational classification of circularRNA from other lncRNA using hybrid features based on multiple kernel learning.
 
Zhaowen Liu, Junying Zhang, Xiguo Yuan, Baobao Liu, Yajun Liu, Aimin Li, Yuanyuan Zhang, Xiaohan Sun and Shouheng Tuo
Mol. BioSyst., 2015, 11, 2227-2237
DOI: 10.1039/C5MB00257E, Paper
We develop a novel computational workflow to analyze the cooperation of miRNAs across cancers by identifying pan-cancer conserved miRNA modules. Such modules are assumed to contribute to cancer hallmarks.
 
Mol. BioSyst., 2015, 11, 2238-2246
DOI: 10.1039/C5MB00110B, Paper
Characterising signal transduction networks is fundamental to our understanding of biology.
 
Mol. BioSyst., 2015, 11, 2247-2254
DOI: 10.1039/C5MB00302D, Paper
The calcium-binding signalling protein S100A4 enhances metastasis in a variety of cancers.
 
Mol. BioSyst., 2015, 11, 2255-2262
DOI: 10.1039/C5MB00196J, Paper
Membrane protein is a central component of the cell that manages intra and extracellular processes.
 
Marco Daniele Parenti, Santina Bruzzone, Alessio Nencioni and Alberto Del Rio
Mol. BioSyst., 2015, 11, 2263-2272
DOI: 10.1039/C5MB00205B, Paper
We report a comprehensive study aimed to classify and identify the selectivity hot-spots for targeting the catalytic cores of human sirtuins using small molecule modulators.
 
Mol. BioSyst., 2015, 11, 2273-2280
DOI: 10.1039/C5MB00222B, Paper
Modules of miRNAs' co-targeting and co-functional network of rice identify miRNAs co-regulating target genes having several interrelated biological processes.
 
Edwin Aoraha, Jason Candreva and Jin Ryoun Kim
Mol. BioSyst., 2015, 11, 2281-2289
DOI: 10.1039/C5MB00280J, Paper
A non-self-aggregating peptide ligand for β-amyloid aggregates created by simple point mutation of an β-amyloid-derived segment.
 
Qing-yong Chen, De-min Jiao, Li Yan, Yu-quan Wu, Hui-zhen Hu, Jia Song, Jie Yan, Li-jun Wu, Li-qun Xu and Jian-guo Shi
Mol. BioSyst., 2015, 11, 2290-2302
DOI: 10.1039/C4MB00734D, Paper
Metastasis associated miRNA–gene network in lung cancer.
 
Mol. BioSyst., 2015, 11, 2303-2311
DOI: 10.1039/C5MB00262A, Paper
From themed collection Chemical Biology in Molecular BioSystems
3C protease of Coxsackievirus B3 (CVB3) plays an essential role in the viral replication cycle, and therefore, emerged as an attractive therapeutic target for the treatment of human diseases caused by CVB3 infection.
 
Gerard Kian-Meng Goh, A. Keith Dunker and Vladimir N. Uversky
Mol. BioSyst., 2015, 11, 2312-2323
DOI: 10.1039/C5MB00277J, Paper
This study involves measurements of percentages of intrinsic disorder (PIDs) in the GAG protein shells of various retroviruses.
 
Jitendra Maharana, Budheswar Dehury, Jyoti Ranjan Sahoo, Itishree Jena, Aritra Bej, Debashis Panda, Bikash Ranjan Sahoo, Mahesh Chandra Patra and Sukanta Kumar Pradhan
Mol. BioSyst., 2015, 11, 2324-2336
DOI: 10.1039/C5MB00212E, Paper
Zebrafish NOD1 and NOD2 used an acidic surface for RIP2-mediated CARD–CARD interaction like Apaf1-procaspase9.
 
Gerard Kian-Meng Goh, A. Keith Dunker and Vladimir N. Uversky
Mol. BioSyst., 2015, 11, 2337-2344
DOI: 10.1039/C5MB00240K, Paper
The underlying reasons for the differences in the virulence of various types of Ebola virus (EBOV) remain unknown.
 
Mol. BioSyst., 2015, 11, 2345-2353
DOI: 10.1039/C5MB00264H, Paper
Glioblastoma (GBM) is the most common malignant brain cancer in adults.
 

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