Journal cover: Molecular BioSystems

Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.
Impact Factor 3.183 12 Issues per Year Indexed in MEDLINE
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Molecular BioSystems,
01 February 2015 , Issue 2,
Page 321 to 666
Mol. BioSyst., 2015, 11, 333-337
DOI: 10.1039/C4MB00485J, Opinion
Regulon prediction tools are trendy in system biology but software developers, concerned for providing reliable outputs, often impose rigid screening parameters. We discuss and illustrate why biologists should utilize tools that allow lowering threshold scores set by default in order to discover unexpected but essential cistrans relationships.
Mol. BioSyst., 2015, 11, 338-353
DOI: 10.1039/C4MB00627E, Review Article
Amide bond-containing (ABC) biomolecules are some of the most structurally intriguing and functionally significant natural products with unmatched utility in medicine, agriculture and biotechnology.
Mol. BioSyst., 2015, 11, 354-360
DOI: 10.1039/C4MB00569D, Method
RFCoil is a novel predictor for parallel coiled-coil dimer and trimer.
Nobuaki Takemori, Ayako Takemori, Kazuhiro Matsuoka, Ryo Morishita, Natsuki Matsushita, Masato Aoshima, Hiroyuki Takeda, Tatsuya Sawasaki, Yaeta Endo and Shigeki Higashiyama
Mol. BioSyst., 2015, 11, 361-365
DOI: 10.1039/C4MB00556B, Communication
A novel strategy for quantitating transmembrane proteome.
Do-Hyoung Kim, Chewook Lee, Ye-Jin Cho, Si-Hyung Lee, Eun-Ji Cha, Ji-Eun Lim, T. Michael Sabo, Christian Griesinger, Donghan Lee and Kyou-Hoon Han
Mol. BioSyst., 2015, 11, 366-369
DOI: 10.1039/C4MB00532E, Communication
The eIF4E–binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures. We show here that it contains a pre-structured helix that presages the eIF4E-bound helix.
Jieming Guo, Xinlei Lian, Jiayong Zhong, Tong Wang and Gong Zhang
Mol. BioSyst., 2015, 11, 370-378
DOI: 10.1039/C4MB00462K, Paper
Considering translational errors, length-dependent translation initiation optimizes the energy cost for maintaining a functional proteome.
C. Airoldi, F. Tripodi, C. Guzzi, R. Nicastro and P. Coccetti
Mol. BioSyst., 2015, 11, 379-383
DOI: 10.1039/C4MB00452C, Paper
We present a rapid and reproducible protocol for intracellular metabolite extraction from yeast cells analyzed by 1H-NMR spectroscopy.
Yongjing Liu, Rui Zhang, Fujun Qiu, Kening Li, Yuanshuai Zhou, Desi Shang and Yan Xu
Mol. BioSyst., 2015, 11, 384-393
DOI: 10.1039/C4MB00439F, Paper
We constructed a lncRNA–PCG bipartite network by sample correlation and identified cancer-related lncRNAs.
Shaojie Ma, Guohua Zeng, Danqing Fang, Juping Wang, Wenjuan Wu, Wenguo Xie, Shepei Tan and Kangcheng Zheng
Mol. BioSyst., 2015, 11, 394-406
DOI: 10.1039/C4MB00350K, Paper
Recently, the development of Src/Abl (c-Src/Bcr–Abl tyrosine kinases) dual inhibitors has attracted considerable attention from the research community for the treatment of malignancies.
Ge Dong, Junsong Wang, Pingping Guo, Dandan Wei, Minghua Yang and Lingyi Kong
Mol. BioSyst., 2015, 11, 407-417
DOI: 10.1039/C4MB00583J, Paper
A 1H NMR based metabolomics approach combined with serum biochemistry and histopathological examination was used to study the toxicity of Arisaematis Rhizoma by intragastrical administration for the first time.
Chengyan Zhou, Gang Li, Yanchuan Li, Liya Gong, Yifan Huang, Zhiping Shi, Shanshan Du, Ying Li, Maoqing Wang, Jun Yin and Changhao Sun
Mol. BioSyst., 2015, 11, 418-433
DOI: 10.1039/C4MB00421C, Paper
This paper was designed to study metabolomic characters of the high-fat diet (HFD)-induced hyperlipidemia and the intervention effects of Mangiferin (MG).
Mol. BioSyst., 2015, 11, 434-453
DOI: 10.1039/C4MB00457D, Paper
Computational analysis using temporal logic shows how brain microglia could switch between phenotypes in response to amyloid-β or cytokines.
Mol. BioSyst., 2015, 11, 454-462
DOI: 10.1039/C4MB00591K, Paper
Upon entering the blood stream, gold nanoparticles form molecular complexes with the encountered proteins such as albumin. Using molecular dynamics simulations, we have shown that with albumin exposure to the gold nanoparticles, the alpha helix amount reduced and ligand-binding sites altered by this structural change.
Shenghua Gu, Bei Cao, Runbin Sun, Yueqing Tang, Janice L. Paletta, Xiao-Lei Wu, Linsheng Liu, Weibin Zha, Chunyan Zhao, Yan Li, Jason M. Radlon, Phillip B. Hylemon, Huiping Zhou, Jiye Aa and Guangji Wang
Mol. BioSyst., 2015, 11, 463-474
DOI: 10.1039/C4MB00500G, Paper
The turnover of bile acids was involved in the lipid lowering effect of orally administered berberine.
Mol. BioSyst., 2015, 11, 475-485
DOI: 10.1039/C4MB00625A, Paper
Identifying protein–protein interaction (PPI) sites plays an important and challenge role in some topics of biology.
Mol. BioSyst., 2015, 11, 486-496
DOI: 10.1039/C4MB00529E, Paper
Metabonomics analysis revealed the presumable pathological processes in the early stages of AMI and provided useful information on the pretreatment efficacy of DQTM.
Yiran Wu, Xiaolong Zhuo, Ziwei Dai, Xiao Guo, Yao Wang, Chuanmao Zhang and Luhua Lai
Mol. BioSyst., 2015, 11, 497-505
DOI: 10.1039/C4MB00610K, Paper
A mammalian cell mitotic network model was built and two effective anti-cancer drug combinations, Aurora B/PLK1 and microtubule formation/PLK1, were identified.
Mol. BioSyst., 2015, 11, 506-515
DOI: 10.1039/C4MB00523F, Paper
This study aimed to investigate the toxic effects of long-term, low-dose acephate administration on rats using ultra-performance liquid chromatography-mass spectrometry.
Haiyu Zhang, Tingting Ge, Xiaoming Cui, Yan Hou, Chaofu Ke, Meng Yang, Kai Yang, Jingtao Wang, Bing Guo, Fan Zhang, Ge Lou and Kang Li
Mol. BioSyst., 2015, 11, 516-521
DOI: 10.1039/C4MB00407H, Paper
Plasma metabolic profiling yielded a panel of prognostic biomarkers, which strongly predicted ovarian cancer recurrence and could potentially shape individualized treatments in the future.
Tarique Sarwar, Mohammed Amir Husain, Sayeed Ur Rehman, Hassan Mubarak Ishqi and Mohammad Tabish
Mol. BioSyst., 2015, 11, 522-531
DOI: 10.1039/C4MB00636D, Paper
Minor groove binding of esculetin with Ct-DNA was established by a series of in vitro experiments and in silico analyses.
Xing-Xing He, Shu-Zhen Kuang, Jia-Zhi Liao, Chuan-Rui Xu, Ying Chang, Yu-Liang Wu, Jing Gong, De-An Tian, An-Yuan Guo and Ju-Sheng Lin
Mol. BioSyst., 2015, 11, 532-539
DOI: 10.1039/C4MB00563E, Paper
DNA methylation plays a complex role in the regulation of miRNA expression and the development of hepatocellular carcinoma.
Mol. BioSyst., 2015, 11, 540-548
DOI: 10.1039/C4MB00161C, Paper
Shengmai injection protects against IR injury through modulation of the myocardial energy metabolism to improve cardiac efficiency through multiple metabolic pathways.
Mol. BioSyst., 2015, 11, 549-557
DOI: 10.1039/C4MB00540F, Paper
Pharmacophoric features of potent BACE inhibitors derived from multi-chemometric studies.
Mol. BioSyst., 2015, 11, 558-563
DOI: 10.1039/C4MB00645C, Paper
Mycobacterium tuberculosis is a bacterium that causes tuberculosis, one of the most prevalent infectious diseases.
Katja Gehmlich, Michael S. Dodd, J. William Allwood, Matthew Kelly, Mohamed Bellahcene, Heena V. Lad, Alexander Stockenhuber, Charlotte Hooper, Houman Ashrafian, Charles S. Redwood, Lucie Carrier and Warwick B. Dunn
Mol. BioSyst., 2015, 11, 564-573
DOI: 10.1039/C4MB00594E, Paper
Perhexiline induces a distinct metabolic phenotype change in a mouse model of hypertrophic cardiomyopathy as defined by a metabolomics approach.

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