Journal cover: Molecular BioSystems

Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.
Impact Factor 3.35 12 Issues per Year Indexed in MEDLINE
 
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Molecular BioSystems,
01 September 2014 , Issue 9,
Page 2261 to 2484
Xuexin Yu, Baofeng Lian, Lihong Wang, Yan Zhang, Enyu Dai, Fanlin Meng, Dianming Liu, Shuyuan Wang, Xinyi Liu, Jing Wang, Xia Li and Wei Jiang
Mol. BioSyst., 2014, 10, 2270-2276
DOI: 10.1039/C4MB00258J, Paper
Although several studies have investigated the essential roles of inflammation in tumor progression, not many have systematically analyzed gene expression patterns across diverse cancers in the context of inflammation.
 
Mol. BioSyst., 2014, 10, 2277-2288
DOI: 10.1039/C4MB00230J, Paper
The network motif model better captures the age-dependency and topological characteristics of yeast protein–protein interaction networks.
 
Samuel Bertrand, Antonio Azzollini, Olivier Schumpp, Nadine Bohni, Jacques Schrenzel, Michel Monod, Katia Gindro and Jean-Luc Wolfender
Mol. BioSyst., 2014, 10, 2289-2298
DOI: 10.1039/C4MB00223G, Paper
A multi-well approach was developed for time series studies of de novo metabolite-induction by fungal co-culture using untargeted metabolomics.
 
Warren C. Byrd, Sarah Schwartz-Baxter, Jim Carlson, Silvana Barros, Steven Offenbacher and Sompop Bencharit
Mol. BioSyst., 2014, 10, 2299-2304
DOI: 10.1039/C4MB00185K, Paper
Denture stomatitis is an interaction between host and candidal organisms modifying by proteins from serum, tissue, and saliva as well as microbial environment of the denture.
 
Yong Tan, Joshua Ko, Xinru Liu, Cheng Lu, Jian Li, Cheng Xiao, Li Li, Xuyan Niu, Miao Jiang, Xiaojuan He, Hongyan Zhao, Zhongxiao Zhang, Zhaoxiang Bian, Zhijun Yang, Ge Zhang, Weidong Zhang and Aiping Lu
Mol. BioSyst., 2014, 10, 2305-2316
DOI: 10.1039/C4MB00072B, Paper
Two metabolic markers were identified.
 
Jing Bai, Yongsheng Li, Tingting Shao, Zheng Zhao, Yuan Wang, Aiwei Wu, Hong Chen, Shengli Li, Chunjie Jiang, Juan Xu and Xia Li
Mol. BioSyst., 2014, 10, 2317-2328
DOI: 10.1039/C4MB00169A, Paper
By integrating the analysis of large numbers of gene expression, we revealed microRNA-mediated pathway crosstalk among Crohn's disease, ulcerative colitis and colorectal cancer.
 
Mol. BioSyst., 2014, 10, 2329-2337
DOI: 10.1039/C4MB00234B, Paper
The overall strategy used for the proteome-wide comprehensive computational investigation to identify outer membrane proteins from Mycobacterium avium subsp. paratuberculosis.
 
Mol. BioSyst., 2014, 10, 2338-2346
DOI: 10.1039/C4MB00264D, Paper
Stochastic modelling of two-component signalling networks reveals active-state locking and growth-rate dependent bistability.
 
Mol. BioSyst., 2014, 10, 2347-2357
DOI: 10.1039/C4MB00263F, Paper
We developed a computational model that accounts for essential kinetic features of thrombin generation, fibrin formation, and fibrinolysis in diverse in vitro systems. We applied it to characterize strategies to improve hemostasis.
 
Lucienne Tritten, Jennifer Keiser, Tasneem Karwa, Jürg Utzinger, Elaine Holmes and Jasmina Saric
Mol. BioSyst., 2014, 10, 2358-2367
DOI: 10.1039/C4MB00097H, Paper
The purpose of this study was to give a comprehensive insight into the systemic metabolic phenotype of mice with a single or dual infection with Plasmodium berghei and Heligmosomoides bakeri.
 
Mol. BioSyst., 2014, 10, 2368-2383
DOI: 10.1039/C4MB00083H, Paper
A newly designed pyridinylhydroxylamine drug candidate can be an effective antidote both kinetically and structurally to reactivate the tabun-inhibited AChE enzyme.
 
Charuvaka Muvva, E. R. Azhagiya Singam, S. Sundar Raman and V. Subramanian
Mol. BioSyst., 2014, 10, 2384-2397
DOI: 10.1039/C4MB00243A, Paper
Molecular Modeling tools have been applied to identify the inhibitors of BRD4.
 
Mei-Ling Liu, Peng Zheng, Zhao Liu, Yi Xu, Jun Mu, Jing Guo, Ting Huang, Hua-Qing Meng and Peng Xie
Mol. BioSyst., 2014, 10, 2398-2406
DOI: 10.1039/C4MB00157E, Paper
A GC-MS based metabolomic approach was applied to characterize the metabolic profiling of schizophrenia subjects (n = 69) and healthy controls (n = 85) in peripheral blood mononuclear cells (PBMCs) to identify and validate biomarkers for schizophrenia.
 
Mol. BioSyst., 2014, 10, 2407-2414
DOI: 10.1039/C4MB00193A, Paper
Ion channels play many crucial functions in life.
 
Catherine Cerutti, Giampiero Bricca, Sophie Rome, Christian Z. Paultre and Marie-Paule Gustin
Mol. BioSyst., 2014, 10, 2415-2425
DOI: 10.1039/C4MB00024B, Paper
The cardiac functional coupling of energy production and cardiac contraction is driven by common transcriptional regulators positively or inversely coordinated with both functions.
 
Pingping Guo, Junsong Wang, Ge Dong, Dandan Wei, Minghui Li, Minghua Yang and Lingyi Kong
Mol. BioSyst., 2014, 10, 2426-2440
DOI: 10.1039/C4MB00251B, Paper
NMR based metabolomics approach combined with OSC-PLSDA was applied to investigate the chronic toxicity of crude ricin from castor bean kernels on rats for the first time.
 
Junli Du, Zhifa Yuan, Ziwei Ma, Jiuzhou Song, Xiaoli Xie and Yulin Chen
Mol. BioSyst., 2014, 10, 2441-2447
DOI: 10.1039/C4MB00287C, Paper
The KEGG-PATH approach, a kind of data mining through functional enrichment analysis of time-course experiments or those involving multiple treatments, can uncover the complex regulation mechanisms of KEGG pathways through the subdivision of total effect.
 
Mol. BioSyst., 2014, 10, 2448-2458
DOI: 10.1039/C4MB00219A, Paper
Viral proteins bridging unconnected components of the Hu-PPI network play a crucial role in viral replication and hence form attractive targets for therapeutic interventions.
 
Mol. BioSyst., 2014, 10, 2459-2465
DOI: 10.1039/C4MB00117F, Paper
We have developed a flexibility-incorporated optimization framework, flexoFBA, to calculate intracellular metabolic fluxes based on a few extracellular measurement constraints.
 
Mol. BioSyst., 2014, 10, 2466-2479
DOI: 10.1039/C4MB00274A, Paper
PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1) encoded by the polymorphic multi-copy var gene family plays an important role in parasite biology and the host–parasite interactions.
 

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