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Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
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Molecular BioSystems,
01 November 2016 , Issue 11,
Page 3237 to 3504
Yifan Lian, Zeling Cai, Huangbo Gong, Songling Xue, Dongdong Wu and Keming Wang
Mol. BioSyst., 2016, 12, 3247-3253
DOI: 10.1039/C6MB00475J, Review Article
We focus on the current knowledge of HOTTIP in various cancers and illustrate the corresponding mechanism and biological function of HOTTIP during tumor development.
Mol. BioSyst., 2016, 12, 3254-3258
DOI: 10.1039/C6MB00551A, Communication
Systemic analysis of stress transcriptomics reveals that ROS and redox changes may universally trigger stress responses in Synechocystis (cyanobacteria).
Mol. BioSyst., 2016, 12, 3259-3265
DOI: 10.1039/C6MB00517A, Communication
The binding parameters of substrates with enzyme TAG revealed that it exhibits selectivity for 3mA over the normal adenine base. The results obtained from the experiments are useful in designing of competitive inhibitors.
Yang Yu, Matej Skočaj, Mateja Erdani Kreft, Nataša Resnik, Peter Veranič, Pietro Franceschi, Kristina Sepčić and Graziano Guella
Mol. BioSyst., 2016, 12, 3266-3279
DOI: 10.1039/C6MB00477F, Paper
A joint NMR/LC-MS approach allows to establish significant differences in the lipidoma of invasive urothelial carcinoma cells (T24) with respect to noninvasive urothelial cells (RT4).
Mol. BioSyst., 2016, 12, 3280-3293
DOI: 10.1039/C6MB00521G, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
The fluctuation correlation network of M2/NS5B includes some hub nodes and the information flow can freely transfer through this network.
Mol. BioSyst., 2016, 12, 3294-3306
DOI: 10.1039/C6MB00489J, Paper
Assessing the influence of nearest neighbors on the conformational ensemble of amino acid residues in unfolded and intrinsically disordered proteins and peptides is pivotal for a thorough understanding of the statistical coil state of unfolded proteins as well as of the energetics of the folding process.
Mol. BioSyst., 2016, 12, 3307-3311
DOI: 10.1039/C6MB00471G, Paper
RNA 5-methylcytosine (m5C) has been discovered from archaea to eukaryotes, which is catalyzed by RNA methyltransferase.
Shang Li, Yanjun Xu, Zeguo Sun, Li Feng, Desi Shang, Chunlong Zhang, Xinrui Shi, Junwei Han, Fei Su, Haixiu Yang, Jianmei Zhao, Chao Song, Yunpeng Zhang, Chunquan Li and Xia Li
Mol. BioSyst., 2016, 12, 3312-3323
DOI: 10.1039/C6MB00101G, Paper
An integrative analysis of expression profile data reveals the lncRNA-involved functional module for esophageal cancer subtypes.
Arjun Sengupta, Soumita Ghosh, Bidyut K. Das, Abhinash Panda, Rina Tripathy, Sylviane Pied, B. Ravindran, Sulabha Pathak, Shobhona Sharma and Haripalsingh M. Sonawat
Mol. BioSyst., 2016, 12, 3324-3332
DOI: 10.1039/C6MB00362A, Paper
This first metabolomics report comparing patients of varying severities of falciparum malaria with patients shows lipid and plasma glycoproteins alterations, which may offer diagnostic prognosis.
Shunian Xiang, Zhangming Yan, Ke Liu, Yaou Zhang and Zhirong Sun
Mol. BioSyst., 2016, 12, 3333-3337
DOI: 10.1039/C6MB00536E, Paper
The first web server that provides a user-friendly tool for the prediction and query of A. thaliana mRNA m6A sites.
Mahendra Kumar Prajapat, Isha Shroff, R. G. Brajesh and Supreet Saini
Mol. BioSyst., 2016, 12, 3338-3346
DOI: 10.1039/C6MB00427J, Paper
Cooperation benefits individual cells in a microbial population by helping accomplish tasks which are difficult or non-beneficial for individuals in the population to carry out by themselves. In this work, we analyze a strategy that enables cooperating cells to survive in the presence of cheaters.
Mol. BioSyst., 2016, 12, 3347-3356
DOI: 10.1039/C6MB00500D, Paper
Herbal medicines have long been widely used in the treatment of various complex diseases in China.
Shazia Nafis, Kalaiarasan Ponnusamy, Mohammad Husain, R. K. Brojen Singh and Rameshwar N. K. Bamezai
Mol. BioSyst., 2016, 12, 3357-3369
DOI: 10.1039/C6MB00526H, Paper
NFKB1, SP1 and hsa-let-7a, were identified as key regulators of apoptosis, by network theory through probability of signal propagation, hub-removal and motif analysis.
Mol. BioSyst., 2016, 12, 3370-3376
DOI: 10.1039/C6MB00540C, Paper
We chose the HDV ribozyme with an embedded theophylline aptamer as the sensor domain and the pri-miRNA as the effector domain to engineer a gene-regulatory device, and developed a new approach for inducible RNAi in the control of MAP4K4 gene expression.
Mol. BioSyst., 2016, 12, 3377-3384
DOI: 10.1039/C6MB00457A, Paper
Predictive permeability models, based on compounds obtained from the cell- and enzyme-based data of Mtb inhibitors, have been developed.
Mol. BioSyst., 2016, 12, 3385-3395
DOI: 10.1039/C6MB00428H, Paper
Regardless of advances in anti-HIV therapy, HIV infection remains an immense challenge due to the rapid onset of mutation instigating drug resistance.
Mol. BioSyst., 2016, 12, 3396-3406
DOI: 10.1039/C6MB00577B, Paper
Employing the combined strategy to identify novel CCR5 inhibitors and provide a basis for rational drug design.
Sourav RoyChoudhury, Biswa Prasanna Mishra, Tila Khan, Ratna Chattopadhayay, Indrani Lodh, Chaitali Datta Ray, Gunja Bose, Himadri S. Sarkar, Sudha Srivastava, Mamata V. Joshi, Baidyanath Chakravarty and Koel Chaudhury
Mol. BioSyst., 2016, 12, 3407-3416
DOI: 10.1039/C6MB00420B, Paper
A NMR based metabolomics study on Indian PCOS women was divided into discovery and validated phases.
Mol. BioSyst., 2016, 12, 3417-3424
DOI: 10.1039/C6MB00576D, Paper
miR-186 has been reported to be implicated in tumorigenesis and chemoresistance in a few cancer types.
Ruijun Li, Fengyu Li, Qiang Feng, Zhipeng Liu, Zhuye Jie, Bo Wen, Xun Xu, Shilong Zhong, Guanglei Li and Kunlun He
Mol. BioSyst., 2016, 12, 3425-3434
DOI: 10.1039/C6MB00339G, Paper
This work leads to candidate diagnosis biomarker discovery in coronary heart disease which can be developed as a non-invasive and feasible method for CHD diagnosis.
Mol. BioSyst., 2016, 12, 3435-3446
DOI: 10.1039/C6MB00511J, Paper
The structure of αdA promotes its recognition by APE1 but dramatically impedes formation of a catalytically competent complex.
Ivan Kel, Zisong Chang, Nadia Galluccio, Margherita Romeo, Stefano Beretta, Luisa Diomede, Alessandra Mezzelani, Luciano Milanesi, Christoph Dieterich and Ivan Merelli
Mol. BioSyst., 2016, 12, 3447-3458
DOI: 10.1039/C6MB00453A, Paper
SPIRE integrates different univariate and multivariate approaches for eQTL analysis, paying particular attention to the scalability of the procedure in order to support cis- as well as trans-mapping, thus allowing the identification of hotspots in NGS data.
Oveis Jamialahmadi, Ehsan Motamedian and Sameereh Hashemi-Najafabadi
Mol. BioSyst., 2016, 12, 3459-3466
DOI: 10.1039/C6MB00532B, Paper
BiKEGG is a COBRA toolbox extension for (1) inferring reaction correspondences between the KEGG and BiGG databases, and (2) overlaying flux distributions on customized metabolic maps.
Mol. BioSyst., 2016, 12, 3467-3477
DOI: 10.1039/C6MB00585C, Paper
Esophageal carcinoma is one of the most malignant gastrointestinal cancers worldwide, and has a high mortality rate.
Mol. BioSyst., 2016, 12, 3478-3501
DOI: 10.1039/C6MB00609D, Paper
Distance plays an important role in the clustering process for allocating data points to different clusters.

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46 citations
With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent to develop automated methods for analyzing the relationship between the sequences and their functions.
DOI: 10.1039/C5MB00155B
Published: 05 Jun 2015
13 citations
Immunoglobulins, also called antibodies, are a group of cell surface proteins which are produced by the immune system in response to the presence of a foreign substance (called antigen).
DOI: 10.1039/C5MB00883B
Published: 11 Feb 2016
29 citations
MicroRNA precursor identification is an important task in bioinformatics.
DOI: 10.1039/C5MB00050E
Published: 17 Feb 2015

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