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Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
 
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Molecular BioSystems,
01 March 2017 , Issue 3,
Page 435 to 622
Mol. BioSyst., 2017, 13, 443-455
DOI: 10.1039/C6MB00740F, Review Article
We review the role for conventional DNA repair proteins in ribosome biogenesis and ribosome biogenesis factors in DNA repair.
 
Spencer Havis, Wilna J. Moree, Sujina Mali and Steven J. Bark
Mol. BioSyst., 2017, 13, 456-462
DOI: 10.1039/C6MB00735J, Review Article
Solid-support resins are critical components of AP-MS experiments, but their interactions with experimental conditions are underappreciated.
 
Mol. BioSyst., 2017, 13, 463-469
DOI: 10.1039/C6MB00741D, Communication
Analysis of the PDB and 66 proteomes revealed that disordered regions in enzymes occur at similar lengths and frequencies as in non-enzymes.
 
A. Safavi, R. Emamzadeh, M. Nazari, M. Ehsani, S. H. Zarkesh-Esfahani and S. Rahgozar
Mol. BioSyst., 2017, 13, 470-475
DOI: 10.1039/C6MB00652C, Communication
A probe has been designed, produced and assayed for the detection of T-helper cells. The sFv fragment fused to the C-terminus of super Renilla luciferase 8 (Super RLuc8) and the probe successfully used for detection of human CD4+ cells using luminometer.
 
Mol. BioSyst., 2017, 13, 476-488
DOI: 10.1039/C6MB00795C, Paper
From themed collection 2017 Hot Articles in Molecular Biosystems
The molecular basis of protein–partner selection and DNA binding of the basic helix–loop–helix (bHLH) and basic region-leucine zipper (bZIP) superfamilies of dimeric transcription factors is fundamental toward understanding gene regulation.
 
Mol. BioSyst., 2017, 13, 489-497
DOI: 10.1039/C6MB00672H, Paper
From themed collection 2017 Hot Articles in Molecular Biosystems
The proposed method correctly identified and accurately quantified primary enzymatic alterations in cancer, and these account for over 80% of the metabolic alterations in the investigated carcinoma.
 
Darleny Y. Lizardo, Yen-Lung Lin, Omer Gokcumen and G. Ekin Atilla-Gokcumen
Mol. BioSyst., 2017, 13, 498-509
DOI: 10.1039/C6MB00842A, Paper
From themed collection 2017 Hot Articles in Molecular Biosystems
In this work, we show that lipids are highly regulated at transcriptome and metabolite level during replicative senescence.
 
Mol. BioSyst., 2017, 13, 510-524
DOI: 10.1039/C6MB00850J, Paper
From themed collection 2017 Hot Articles in Molecular Biosystems
The translationally controlled tumor protein (TCTP) is a highly conserved multifunctional protein, preferentially expressed in mitotically active tissues and is a potential biomarker and a therapeutic target for lung cancers.
 
Bin Huang, Yuran Peng, Jingjing Li, Shang Li, Yicheng Sun, Decai Wang, Binrui Yang, Judy Yuet-Wa Chan, Huidong Yu, George Pak-Heng Leung, Maggie Pui-Man Hoi, Guo-Chun Zhou and Simon Ming-Yuen Lee
Mol. BioSyst., 2017, 13, 525-536
DOI: 10.1039/C6MB00641H, Paper
A new andrographolide derivative AGP-26b exhibits anti-angiogenic activity in HUVECs and zebrafish.
 
Wei Liu, Wei Wang, Guohua Tian, Wenming Xie, Li Lei, Jiujin Liu, Wanxun Huang, Liyan Xu and Enmin Li
Mol. BioSyst., 2017, 13, 537-548
DOI: 10.1039/C6MB00757K, Paper
Toward precise survival outcome prediction by inferring survival associated pathway activities.
 
Mol. BioSyst., 2017, 13, 549-555
DOI: 10.1039/C6MB00615A, Paper
Network based approach for finding biomarkers for predicting the clinical behavior of cervical neoplasia cells at its earliest onset.
 
Mol. BioSyst., 2017, 13, 556-564
DOI: 10.1039/C6MB00824K, Paper
Ischemic arrhythmias are the main causes of sudden cardiac death.
 
Jyoti Roy, Arijita Sarkar, Sibun Parida, Zhumur Ghosh and Bibekanand Mallick
Mol. BioSyst., 2017, 13, 565-576
DOI: 10.1039/C6MB00699J, Paper
For the first time, this study reports specific piRNA signatures in a healthy human brain and an AD-diagnosed brain and decrypted the regulatory roles of dysregulated piRNAs in the pathogenesis of AD.
 
Yongming Yu, Licai Yang, Zhiping Liu and Chuansheng Zhu
Mol. BioSyst., 2017, 13, 577-584
DOI: 10.1039/C6MB00806B, Paper
Predicting bacterial essential genes using only fractal features.
 
Mol. BioSyst., 2017, 13, 585-597
DOI: 10.1039/C6MB00803H, Paper
The first account of the dynamic features of the loop region of VP40 of the Ebola virus (EboV) using accelerated molecular dynamics (aMD) simulations is reported herein.
 
Huili Guo, Yadong Yang, Feiyan Xue, Hong Zhang, Tiran Huang, Wenbin Liu, Huan Liu, Fenqiang Zhang, Mingfeng Yang, Chunmei Liu, Heshu Lu, Yansheng Zhang and Lanqing Ma
Mol. BioSyst., 2017, 13, 598-606
DOI: 10.1039/C6MB00563B, Paper
The flexible linker length has a direct effect on the catalytic efficiency of fusion protein 4CL::STS.
 
Mol. BioSyst., 2017, 13, 607-620
DOI: 10.1039/C6MB00553E, Paper
The first genome-scale metabolic network for Bradyrhizobium was constructed and the metabolic properties were compared between the free-living and symbiotic physiological states.
 

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57 citations
With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent to develop automated methods for analyzing the relationship between the sequences and their functions.
DOI: 10.1039/C5MB00155B
Published: 05 Jun 2015
18 citations
Immunoglobulins, also called antibodies, are a group of cell surface proteins which are produced by the immune system in response to the presence of a foreign substance (called antigen).
DOI: 10.1039/C5MB00883B
Published: 11 Feb 2016
13 citations
ReactomePA is an R package providing functional analyses at the gene and sequence levels, with several visualization functions provided.
DOI: 10.1039/C5MB00663E
Published: 23 Nov 2015

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