Journal cover: Molecular BioSystems

Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.
Impact Factor 3.35 12 Issues per Year Indexed in MEDLINE
 
arrow_left Prev Pg 1 of 1 Next arrow_right
Molecular BioSystems,
01 August 2014 , Issue 8,
Page 1989 to 2260
Mol. BioSyst., 2014, 10, 1998-2022
DOI: 10.1039/C4MB00147H, Review Article
Medicinal chemistry methodologies used in the drug discovery of highly validated viral targets.
 
Mol. BioSyst., 2014, 10, 2023-2030
DOI: 10.1039/C4MB00053F, Method
A new method that uses Bayesian model averaging for linear regression to infer molecular interactions in biological systems with high prediction accuracy and high computational efficiency.
 
Yanyan Ping, Hongyi Zhang, Yulan Deng, Li Wang, Hongying Zhao, Lin Pang, Huihui Fan, Chaohan Xu, Feng Li, Yong Zhang, Yonghui Gong, Yun Xiao and Xia Li
Mol. BioSyst., 2014, 10, 2031-2042
DOI: 10.1039/C4MB00289J, Method
Due to the extensive complexity and high genetic heterogeneity of genetic alterations in cancer, comprehensively depicting the molecular mechanisms of cancer remains difficult.
 
Amit Kumar, Paola Melis, Vito Genna, Eleonora Cocco, Maria Giovanna Marrosu and Enrico Pieroni
Mol. BioSyst., 2014, 10, 2043-2054
DOI: 10.1039/C4MB00203B, Paper
DRB1–DQB1 binding affinities in peptide molecular recognition process. (A) In protective haplotype DRB1 allele displays a preferential affinity for MBP peptide, while (B) in predisposing haplotype DQB1 allele displays a preferential affinity for EBNA1 peptide.
 
Feng Zhang, Qin Zhan, Xin Dong, Bo Jiang, Lianna Sun, Shouhong Gao, Zhiqing He, Xia Tao and WanSheng Chen
Mol. BioSyst., 2014, 10, 2055-2063
DOI: 10.1039/C4MB00055B, Paper
Shengxian Decoction (SXT), a classic Traditional Chinese Medicine (TCM) prescription, consists of five TCMs: Astragali Radix, Anemarrhenae Rhizoma, Bupleuri Radix, Platycodonis Radix (PG), and Cimicifugae Rhizoma.
 
Domenico Fraccalvieri, Stefano Motta, Guido Galliani, Linda Cavaletti and Laura Bonati
Mol. BioSyst., 2014, 10, 2064-2073
DOI: 10.1039/C4MB00085D, Paper
A computational study on the binding of celiac disease relevant epitopes and their analogues identified the di-hydroxylation of Pro residues as a promising functionalization to lower the affinity for HLA–DQ2.5.
 
Jie Sun, Hongbo Shi, Zhenzhen Wang, Changjian Zhang, Lin Liu, Letian Wang, Weiwei He, Dapeng Hao, Shulin Liu and Meng Zhou
Mol. BioSyst., 2014, 10, 2074-2081
DOI: 10.1039/C3MB70608G, Paper
Accumulating evidence demonstrates that long non-coding RNAs (lncRNAs) play important roles in the development of complex human diseases. Predicting novel human lncRNA–disease associations is a challenging and essential task.
 
Marcel Mischnik, Stepan Gambaryan, Hariharan Subramanian, Jörg Geiger, Claudia Schütz, Jens Timmer and Thomas Dandekar
Mol. BioSyst., 2014, 10, 2082-2089
DOI: 10.1039/C4MB00170B, Paper
A kinetic description of the fragile equilibrium in thrombozytes regulating blood flow would be an important basis for rational medical interventions.
 
Mol. BioSyst., 2014, 10, 2090-2105
DOI: 10.1039/C4MB00126E, Paper
Clostridium acetobutylicum is a strict anaerobe which exhibits two distinct steps in its metabolic network.
 
Christos Deligkaris, Anthony Thomas Ascone, Kevin Joseph Sweeney and Alan Jonathan Quentin Greene
Mol. BioSyst., 2014, 10, 2106-2125
DOI: 10.1039/C4MB00239C, Paper
We discuss reasons for the successes and failures, implications, and the importance of ensuring an adequate search in docking calculations.
 
Yan Hou, Mingzhu Yin, Fengyu Sun, Tao Zhang, Xiaohua Zhou, Huiyan Li, Jian Zheng, Xiuwei Chen, Cong Li, Xiaoming Ning, Ge Lou and Kang Li
Mol. BioSyst., 2014, 10, 2126-2133
DOI: 10.1039/C4MB00054D, Paper
Cervical cancer is a clinical and pathological heterogeneity disease, which requires different types of treatments and leads to a variety of outcomes.
 
Angela Messina, Simona Reina, Francesca Guarino, Andrea Magrì, Flora Tomasello, Richard E. Clark, Rona R. Ramsay and Vito De Pinto
Mol. BioSyst., 2014, 10, 2134-2145
DOI: 10.1039/C4MB00237G, Paper
From themed collection Italian Proteomics Association, 2014
In higher eukaryotes three different VDAC genes encode three homologous proteins which do not show the same activity.
 
Mol. BioSyst., 2014, 10, 2146-2159
DOI: 10.1039/C4MB00071D, Paper
A potent Jak2 inhibitor could solve numerous diseases and so identifying a potent Jak2 inhibitor could be a jackpot for the pharmaceutical industry. Extensive computational analysis was carried out to identify potent Jak2 inhibitors.
 
Aihua Zhang, Xiaohang Zhou, Hongwei Zhao, Yu Guan, Shiyu Zhou, Guang-li Yan, Zhonghua Ma, Qi Liu and Xijun Wang
Mol. BioSyst., 2014, 10, 2160-2165
DOI: 10.1039/C4MB00222A, Paper
Detailed analysis workflow of TransOmics informatics for metabolomics data from large biological data sets.
 
Mol. BioSyst., 2014, 10, 2166-2175
DOI: 10.1039/C4MB00217B, Paper
Substances containing an α-amino-β-mercapto-ethane pharmacophore may be used as effective methylglyoxal scavengers and inhibitors of protein carbonylation and cross-linking.
 
Steven V. Rødkær, Dennis Pultz, Michelle Brusch, Martin V. Bennetzen, Lasse G. Falkenby, Jens S. Andersen and Nils J. Færgeman
Mol. BioSyst., 2014, 10, 2176-2188
DOI: 10.1039/C4MB00207E, Paper
The molecular mechanisms underlying how cells sense, respond, and adapt to alterations in nutrient availability have here been studied extensively by phosphoproteomics.
 
Mol. BioSyst., 2014, 10, 2189-2201
DOI: 10.1039/C4MB00077C, Paper
Combined QM–MM studies are conducted to determine the CDK2 and 3,5-diaminoindazole inhibitors interaction energy with quantum chemical descriptors, which provides a novel scaffold for further optimization of CDK2 inhibitors that can improve the selectivity.
 
Fangfang Deng, Shuying Ma, Meihong Xie, Xiaoyun Zhang, Peizhen Li and Honglin Zhai
Mol. BioSyst., 2014, 10, 2202-2214
DOI: 10.1039/C4MB00183D, Paper
A good consistency in the docking and dynamics simulations provides important information on residues and binding mode, which can aid in the further study TLR8 agonists.
 
Mol. BioSyst., 2014, 10, 2215-2228
DOI: 10.1039/C4MB00253A, Paper
The emergence of different drug resistant strains of HIV-1 reverse transcriptase (HIV RT) remains of prime interest in relation to viral pathogenesis as well as drug development.
 
Mahesh Chandra Patra, Jitendra Maharana, Budheswar Dehury and Sachinandan De
Mol. BioSyst., 2014, 10, 2236-2246
DOI: 10.1039/C4MB00214H, Paper
Inactive-state conformation of the novel NPBWR1 and its antagonist binding modes were explored through MD-simulation and binding free energy calculations.
 
Mol. BioSyst., 2014, 10, 2247-2258
DOI: 10.1039/C4MB00088A, Paper
Atomistic graph–theoretical analysis of caspase-1 reveals details of intra-protein communication pathways.
 
, 2014, 10, 2229-2235
DOI: 10.1039/C4MB00316K
The bacteriophage virion proteins play extremely important roles in the fate of host bacterial cells.
 

Search this Journal

Find an Issue

Molecular BioSystems (2005-Present)
Year *
Issue

Find an Article

Journal*
Year*
Page 

Related News

H ow to explain your research and organize the data in an effective and logical way for publication in an STM journal? S ong Gao, Professor of Chemist...
Chemical Science , launched in 2010, is set to become the world’s first high-quality Open Access chemistry journal. From the first issue in January 20...
RSC Publishing Blog 15 Jul 2014
Those who publish with us and read our journals will know that we take our responsibility as a publisher very seriously. Now, we’re taking that respon...
RSC Publishing Blog 14 Jul 2014
FMRP regulates miR196a-mediated repression of HOXB8 via interaction with the AGO2 MID domain Ying Li, Wei Tang, Li-rong Zhang and Chun-yang Zhang Mol....