C. Castro, W. Briggs, G. K. Paschos, G. A. FitzGerald and J. L. Griffin
Mol. BioSyst., 2015, 11, 1897-1906
Metabolomics has been used to analyse adipose tissue in mice with an adipocyte-specific deletion of Arntl, showing the importance of the peripheral circadian clock in metabolic regulation. Arntl induces global changes in both white and brown adipose tissues which were distinct for the two tissues.
Tulin Ersahin, Nurcan Tuncbag and Rengul Cetin-Atalay
Mol. BioSyst., 2015, 11, 1946-1954
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signalling pathway is hyperactivated or altered in many cancer types and regulates a broad range of cellular processes including survival, proliferation, growth, metabolism, angiogenesis and metastasis.