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Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
Impact Factor 3.21 12 Issues per Year Indexed in Medline
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Molecular BioSystems,
01 February 2016 , Issue 2,
Page 315 to 680
Caixiu Liao, Yajun Gui, Yuan Guo and Danyan Xu
Mol. BioSyst., 2016, 12, 328-333
DOI: 10.1039/C5MB00806A, Review Article
From themed collection Chemical Biology in Molecular BioSystems
Arrhythmia, the basis of which is cardiomyocyte ion channel abnormalities, poses a serious threat to human health.
Qun Liang, Han Liu, Tianyu Zhang, Yan Jiang, Haitao Xing and Hua Zhang
Mol. BioSyst., 2016, 12, 334-340
DOI: 10.1039/C5MB00572H, Communication
There is a lack of diagnostic tests for cholangiocarcinoma. This report identifies 4 serum metabolites which could differentiate cholangiocarcinoma patients with high accuracy.
Mol. BioSyst., 2016, 12, 341-344
DOI: 10.1039/C5MB00720H, Communication
From themed collection 2016 Hot Articles in Molecular BioSystems
‘Barcoding’ how bacteria bind to simple sugar-surfaces using a training algorithm is used as a powerful identification tool.
Samuel Juillot, Hannes M. Beyer, Josef Madl, Wilfried Weber, Matias D. Zurbriggen and Winfried Römer
Mol. BioSyst., 2016, 12, 345-349
DOI: 10.1039/C5MB00763A, Communication
From themed collection Chemical Biology in Molecular BioSystems
One major regulatory mechanism in cell signalling is the spatio-temporal control of the localization of signalling molecules. We synthetically designed an entire cell signalling pathway, which allows controlling the transport of signalling molecules from the plasma membrane to the nucleus, by using light and small molecules.
Howbeer Muhamadali, Yun Xu, Rosa Morra, Drupad K. Trivedi, Nicholas J. W. Rattray, Neil Dixon and Royston Goodacre
Mol. BioSyst., 2016, 12, 350-361
DOI: 10.1039/C5MB00624D, Paper
In this study we have employed metabolomics approaches to understand the metabolic effects of producing enhanced green fluorescent protein (eGFP) as a recombinant protein in Escherichia coli cells.
Mol. BioSyst., 2016, 12, 362-370
DOI: 10.1039/C5MB00733J, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
This work constitutes the first known report on lncRNA expression patterns of ectopic and eutopic endometrial tissues in human adenomyosis.
Mol. BioSyst., 2016, 12, 371-378
DOI: 10.1039/C5MB00702J, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Transcriptional regulatory cascades are always triggered through the combinatorial interplay between transcription factors (TFs) and microRNAs (miRNAs) in eukaryotes.
Mol. BioSyst., 2016, 12, 379-390
DOI: 10.1039/C5MB00781J, Paper
From themed collection Chemical Biology in Molecular BioSystems
L-type Ca2+ channels (LTCCs), the heteromultimeric proteins, are associated with electrical signaling and provide the key link between electrical signals and non-electrical processes.
Federico Lopez-Moya, David Kowbel, M a José Nueda, Javier Palma-Guerrero, N. Louise Glass and Luis Vicente Lopez-Llorca
Mol. BioSyst., 2016, 12, 391-403
DOI: 10.1039/C5MB00649J, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
In this work we performed the first transcriptional study of a filamentous fungus (N. crassa) in response to chitosan.
Hélène Denis, Olivier Van Grembergen, Benjamin Delatte, Sarah Dedeurwaerder, Pascale Putmans, Emilie Calonne, Françoise Rothé, Christos Sotiriou, François Fuks and Rachel Deplus
Mol. BioSyst., 2016, 12, 404-413
DOI: 10.1039/C5MB00513B, Paper
From themed collection Chemical Biology in Molecular BioSystems
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression.
Mol. BioSyst., 2016, 12, 414-420
DOI: 10.1039/C5MB00590F, Paper
Background: the acquisition of antibiotic resistance in bacterial cells is often accompanied with a reduction of fitness in the absence of antibiotics, known as the “fitness cost”.
Mahendra Kumar Prajapat, Kirti Jain, Debika Choudhury, Nikhil Raj and Supreet Saini
Mol. BioSyst., 2016, 12, 421-430
DOI: 10.1039/C5MB00693G, Paper
Starting with Savageau's pioneering work regarding demand rules for gene regulation from the 1970s, here, we choose the simplest transcription network and ask: how does the cell choose a particular regulatory topology from all available possibilities?
Mol. BioSyst., 2016, 12, 431-443
DOI: 10.1039/C5MB00480B, Paper
Model-based investigation of the metabolism and immunometabolism of CD4+ T cells (CD4T1670) and the application of CD4T1670 in drug development.
Mol. BioSyst., 2016, 12, 444-453
DOI: 10.1039/C5MB00529A, Paper
From themed collection Chemical Biology in Molecular BioSystems
Conformational thermodynamics compares the modeling protocols to identify the conformation of the missing region leading to a suitable model for metal ion free (apo) skeletal muscle Troponin C.
Junpeng Zhang, Thuc Duy Le, Lin Liu, Jianfeng He and Jiuyong Li
Mol. BioSyst., 2016, 12, 454-463
DOI: 10.1039/C5MB00562K, Paper
We present a causality based framework called mirSRN to infer miRNA synergism in human molecular systems.
Mol. BioSyst., 2016, 12, 464-476
DOI: 10.1039/C5MB00622H, Paper
The integrative analysis of transcriptome, regulatory transcriptional network and ethanol tolerance network revealed biological processes affected by ethanol in Saccharomyces cerevisiae.
Mol. BioSyst., 2016, 12, 477-479
DOI: 10.1039/C5MB00663E, Paper
ReactomePA is an R package providing functional analyses at the gene and sequence levels, with several visualization functions provided.
Mol. BioSyst., 2016, 12, 480-489
DOI: 10.1039/C5MB00573F, Paper
From themed collection Chemical Biology in Molecular BioSystems
An effective method used to prepare fusible proteoliposomes reconstituted with phage portal proteins for the black lipid membrane analysis.
Mol. BioSyst., 2016, 12, 490-498
DOI: 10.1039/C5MB00681C, Paper
HydPred was presented as the most reliable tool up to now for the identification of protein hydroxylation sites with a user-friendly web server at
Jinfeng Wang, Yong Zhu, Jiuting Tan, Xiaoxiao Meng, Hui Xie and Ruilan Wang
Mol. BioSyst., 2016, 12, 499-507
DOI: 10.1039/C5MB00698H, Paper
From themed collection Chemical Biology in Molecular BioSystems
Lysyl oxidase (LOX) is a copper-dependent amine oxidase that plays a critical role in pulmonary fibrosis.
Huajun Zheng, Enuo Liu, Tao Shi, Luyi Ye, Tomonobu Konno, Munehiro Oda and Zai-Si Ji
Mol. BioSyst., 2016, 12, 508-519
DOI: 10.1039/C5MB00547G, Paper
This is the first report to describe transcriptome data in Lb. bulgaricus using RNA-seq, and the strain's advantage in yoghurt production were explained by the gene expression profile.
Mol. BioSyst., 2016, 12, 520-531
DOI: 10.1039/C5MB00615E, Paper
From themed collection Chemical Biology in Molecular BioSystems
By implementing label propagation on drug/target similarity network with mutual interaction information derived from drug–target heterogeneous network, LPMIHN algorithm identifies potential drug–target interactions.
Mol. BioSyst., 2016, 12, 532-540
DOI: 10.1039/C5MB00638D, Paper
We have classified the existing RNA-binding protein (RBP) structures into different structural families. Here, we report ∼2600 proteins with RBP signatures in humans.
Ning An, Xue Yang, Yueming Zhang, Xiaoyu Shi, Xuexin Yu, Shujun Cheng, Kaitai Zhang and Guiqi Wang
Mol. BioSyst., 2016, 12, 541-552
DOI: 10.1039/C5MB00761E, Paper
The expression profile of human colorectal developing tissues in 4 sequential stages was accomplished, and V probes and A probes were obtained based on differential expression patterns during embryonic development and carcinogenesis.
Valérie Broeckx, Kurt Boonen, Lentel Pringels, Xavier Sagaert, Hans Prenen, Bart Landuyt, Liliane Schoofs and Evelyne Maes
Mol. BioSyst., 2016, 12, 553-565
DOI: 10.1039/C5MB00670H, Paper
Comparison of protein extraction buffers and overall variation in formalin-fixed paraffin-embedded tissue using the same proteomic workflow.

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