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Journal cover: Molecular BioSystems

Molecular BioSystems

Research at the interface of chemistry and biology: chemical biology, -omics sciences and systems biology.
Impact Factor 2.829 12 Issues per Year Indexed in Medline
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Molecular BioSystems,
01 September 2016 , Issue 9,
Page 2655 to 2942
F. Ceciliani, P. Roccabianca, C. Giudice and C. Lecchi
Mol. BioSyst., 2016, 12, 2665-2679
DOI: 10.1039/C6MB00227G, Review Article
From themed collection Omics in Animal Sciences
We present in this review the most recent achievement in the application of transcriptomics, proteomics and metabolomics to canine cancer research. The protocols to recover material suitable for omics analyses from formalin-fixed, paraffin-embedded tissues are highlighted, together with the potential of omics in veterinary cancer diagnostics.
Josipa Kuleš, Anita Horvatić, Nicolas Guillemin, Asier Galan, Vladimir Mrljak and Mangesh Bhide
Mol. BioSyst., 2016, 12, 2680-2694
DOI: 10.1039/C6MB00268D, Review Article
From themed collection Omics in Animal Sciences
The availability of omics datasets coupled to high-throughput and bioinformatics analyses enabled rational and faster identification of new generation vaccine candidates.
Dawei Xu, Linhai Jiang, Louis DeRidder, Brendan Elmore, Maurish Bukhari, Qiang Wei, Damien S. K. Samways and He Dong
Mol. BioSyst., 2016, 12, 2695-2699
DOI: 10.1039/C6MB00369A, Communication
From themed collection Chemical Biology in Molecular BioSystems
This work explored the membrane activity of filamentous supramolecular peptides and their great potential as a supramolecular peptide-based chemotherapeutic enhancer.
Michał Wojciechowski, Àngel Gómez-Sicilia, Mariano Carrión-Vázquez and Marek Cieplak
Mol. BioSyst., 2016, 12, 2700-2712
DOI: 10.1039/C6MB00214E, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Knots in proteins have been proposed to resist proteasomal degradation, thought in turn to be related to neurodegenerative diseases such as Huntington.
Cheong-Meng Chong, Man-Teng Kou, Peichen Pan, Hefeng Zhou, Nana Ai, Chuwen Li, Hai-Jing Zhong, Chung-Hang Leung, Tingjun Hou and Simon Ming-Yuen Lee
Mol. BioSyst., 2016, 12, 2713-2721
DOI: 10.1039/C6MB00343E, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
Through the combined virtual and high content drug screening, BIPM was identified as a novel and potent ROCK2 inhibitor. Exposure of SH-SY5Y cells to BIPM led to significant changes in neurite length, cell migration and actin stress fibers via mediating ROCK2 downstream proteins.
Mol. BioSyst., 2016, 12, 2722-2734
DOI: 10.1039/C6MB00224B, Paper
From themed collection Omics in Animal Sciences
Adipose tissue and muscle are endocrine organs releasing signalling and mediator proteins termed adipokines and myokines. The identification of the complete set of proteins secreted by adipose tissue and muscle is a challenge to understand the molecular cross-talk between these tissues and to reveal potential targets to control body or muscle composition and metabolism.
Funmilola Clara Thomas, William Mullen, Riccardo Tassi, Adela Ramírez-Torres, Manikhandan Mudaliar, Tom N. McNeilly, Ruth N. Zadoks, Richard Burchmore and P. David Eckersall
Mol. BioSyst., 2016, 12, 2735-2747
DOI: 10.1039/C6MB00239K, Paper
From themed collection Omics in Animal Sciences
Acute phase proteins and a group of 77 peptides in a biomarker panel increase in milk during bovine mastitis caused by a Streptococcus uberis infection of mammary glands.
Manikhandan Mudaliar, Riccardo Tassi, Funmilola C. Thomas, Tom N. McNeilly, Stefan K. Weidt, Mark McLaughlin, David Wilson, Richard Burchmore, Pawel Herzyk, P. David Eckersall and Ruth N. Zadoks
Mol. BioSyst., 2016, 12, 2748-2761
DOI: 10.1039/C6MB00290K, Paper
From themed collection Omics in Animal Sciences
Longitudinal proteomic analysis of bovine milk shows consistent changes over time across cows after intramammary challenge with Streptococcus uberis.
Funmilola Clara Thomas, Manikhandan Mudaliar, Riccardo Tassi, Tom N. McNeilly, Richard Burchmore, Karl Burgess, Pawel Herzyk, Ruth N. Zadoks and P. David Eckersall
Mol. BioSyst., 2016, 12, 2762-2769
DOI: 10.1039/C6MB00289G, Paper
From themed collection Omics in Animal Sciences
Metabolomic investigation of milk from cows with bovine mastitis has revealed major changes in carbohydrates, lipids, amino acids, nucleotides and bile acids.
Jan-Dirk Wehland, Antonina S. Lygina, Pawan Kumar, Samit Guha, Barbara E. Hubrich, Reinhard Jahn and Ulf Diederichsen
Mol. BioSyst., 2016, 12, 2770-2776
DOI: 10.1039/C6MB00294C, Paper
From themed collection Chemical Biology in Molecular BioSystems
Analogs of the Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein Receptor proteins (SNAREs) for mediation of vesicle fusion.
Jiangyong Gu, Philip S. Crosier, Christopher J. Hall, Lirong Chen and Xiaojie Xu
Mol. BioSyst., 2016, 12, 2777-2784
DOI: 10.1039/C6MB00222F, Paper
Network efficiency and network flux are measures of drug efficacy against inflammation.
Ehab H. Mattar, Hussein A. Almehdar, Vladimir N. Uversky and Elrashdy M. Redwan
Mol. BioSyst., 2016, 12, 2785-2797
DOI: 10.1039/C6MB00283H, Paper
From themed collection 2016 Hot Articles in Molecular BioSystems
We revealed that human α- and β-defensins have strong anti-HCV activity in experiments on cellular protection, neutralization, and treatment at low concentrations, whereas synthetic linear avian defensins could reach similar anti-HCV potential only at noticeably higher concentrations.
Insung Na, Fanchi Meng, Lukasz Kurgan and Vladimir N. Uversky
Mol. BioSyst., 2016, 12, 2798-2817
DOI: 10.1039/C6MB00069J, Paper
Recent analyses indicated that autophagy can be regulated via some nuclear transcriptional networks and many important players in the autophagy and other forms of programmed cell death are known to be intrinsically disordered.
Atanu Singha Roy, Sintu Kumar Samanta, Pooja Ghosh, Debi Ranjan Tripathy, Sudip Kumar Ghosh and Swagata Dasgupta
Mol. BioSyst., 2016, 12, 2818-2833
DOI: 10.1039/C6MB00344C, Paper
From themed collection Chemical Biology in Molecular BioSystems
Oxidative DNA damage is confirmed by the morin–Cu(II) complex and it is also able to inhibit the growth of human HeLa cells. The binding of the morin–Cu(II) complex with HSA and BSA occurs mainly through hydrophobic forces.
Mol. BioSyst., 2016, 12, 2834-2848
DOI: 10.1039/C6MB00193A, Paper
The deletion of phenylalanine 508 reshapes the conformational space of the NBD1 domain that populates unique intermediate states that provide insights into the molecular events that underlie the impaired folding of F508del-NBD1.
Mol. BioSyst., 2016, 12, 2849-2858
DOI: 10.1039/C6MB00314A, Paper
From themed collection Chemical Biology in Molecular BioSystems
SOHPRED is a new and competitive bioinformatics tool for characterizing and predicting human S-sulfenylation sites.
Mol. BioSyst., 2016, 12, 2859-2866
DOI: 10.1039/C6MB00423G, Paper
From themed collection Chemical Biology in Molecular BioSystems
Small drug molecules and other important metabolites are delivered via a suitable carrier protein-mediated transport through a specific receptor.
Honorine Lebraud, David J. Wright, Charlotte E. East, Finn P. Holding, Marc O'Reilly and Tom D. Heightman
Mol. BioSyst., 2016, 12, 2867-2874
DOI: 10.1039/C6MB00367B, Paper
From themed collection Chemical Biology in Molecular BioSystems
The trans-cyclooctenol/tetrazine click reaction was used for in-gel ABPP to determine the proteome-wide selectivity profile of a covalent ERK1/2 inhibitor.
Mol. BioSyst., 2016, 12, 2875-2882
DOI: 10.1039/C6MB00104A, Paper
Hubs, the highly connected nodes in protein–protein interaction networks (PPINs), are associated with several characteristic properties and are known to perform vital roles in cells.
Mol. BioSyst., 2016, 12, 2883-2892
DOI: 10.1039/C6MB00381H, Paper
Pancreatic cancer is a highly malignant disease with a poor prognosis and it is essential to diagnose and treat the disease at an early stage.
Chuan Dong, Ya-Zhou Yuan, Fa-Zhan Zhang, Hong-Li Hua, Yuan-Nong Ye, Abraham Alemayehu Labena, Hao Lin, Wei Chen and Feng-Biao Guo
Mol. BioSyst., 2016, 12, 2893-2900
DOI: 10.1039/C6MB00374E, Paper
Pseudo dinucleotide composition (PseDNC) and Z curve showed excellent performance in the classification issues of nucleotide sequences in bioinformatics.
Susmitnarayan Chaudhury, Sudipta Bag, Madhuparna Bose, Amit Kumar Das, Ananta Kumar Ghosh and Swagata Dasgupta
Mol. BioSyst., 2016, 12, 2901-2909
DOI: 10.1039/C6MB00256K, Paper
From themed collection Chemical Biology in Molecular BioSystems
The transparency of the human eye lens depends on the solubility and stability of the structural proteins of the eye lens, the crystallins.
Mol. BioSyst., 2016, 12, 2910-2920
DOI: 10.1039/C6MB00332J, Paper
From themed collection Chemical Biology in Molecular BioSystems
In this paper, we describe the biochemical properties and biological activity of a series of cholinesterase reactivators (symmetrical bisquaternary xylene-linked compounds, K106–K114) with ctDNA.
Mol. BioSyst., 2016, 12, 2921-2931
DOI: 10.1039/C6MB00274A, Paper
An integrated network-based approach is proposed to nominate driver genes. It is composed of two steps including a network diffusion step and an aggregated ranking step, which fuses the correlation between the gene mutations and gene expression, the relationship between the mutated genes and the heterogeneous characteristic of the patient mutation.
Maodong Li, Tanlin Sun, Fan Jin, Daqi Yu and Zhirong Liu
Mol. BioSyst., 2016, 12, 2932-2940
DOI: 10.1039/C6MB00415F, Paper
To extract protein dimension and energetics information from single-molecule fluorescence resonance energy transfer spectroscopy (smFRET) data, it is essential to establish the relationship between the distributions of the radius of gyration (Rg) and the end-to-end (donor-to-acceptor) distance (Ree).

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39 citations
With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent to develop automated methods for analyzing the relationship between the sequences and their functions.
DOI: 10.1039/C5MB00155B
Published: 05 Jun 2015
27 citations
MicroRNA precursor identification is an important task in bioinformatics.
DOI: 10.1039/C5MB00050E
Published: 17 Feb 2015
8 citations
Immunoglobulins, also called antibodies, are a group of cell surface proteins which are produced by the immune system in response to the presence of a foreign substance (called antigen).
DOI: 10.1039/C5MB00883B
Published: 11 Feb 2016

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