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Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 6.115 24 Issues per Year Indexed in Medline
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Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00614G, Critical Review
In recent years there has been an explosion of methods for encapsulating cells in droplets. This review examines the state-of-the-art, including methods for active encapsulation.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00726G, Paper
The ability to manipulate drops with small volumes has many practical applications. Current microfluidic devices generally exploit channel geometry and/or active external equipment to control drops. Here we use a...
Xiaotong Fu, Nicholas Mavrogiannis, Steven Doria and Zachary Gagnon
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC90090E, Correction
Josephine C. Cunningham, Karen Scida, Molly R. Kogan, Bo Wang, Andrew D. Ellington and Richard M. Crooks
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00731C, Paper
A paper analytical device for quantitative electrochemical detection of ricin a chain is reported. It relies on magnetic preconcentration and silver nanoparticle labels to yield a detection limit of 34 pM.
Thanh-Vinh Nguyen, Minh-Dung Nguyen, Hidetoshi Takahashi, Kiyoshi Matsumoto and Isao Shimoyama
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00661A, Paper
We propose a MEMS-based cantilever array to estimate the viscosity of small droplets based on their tapping-induced vibration.
Edward W. Tekwa, Dao Nguyen, David Juncker, Michel Loreau and Andrew Gonzalez
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00576K, Paper
A simple microhabitat chip reveals the effect of patchiness on the evolution of cooperation in bacteria.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00370A, Paper
We present a lab-on-a-chip methodology for the enrichment of ultrasound contrast agents using pinched flow fractionation. We extend the modelling to include relatively large particles, by combining numerical and experimental results. Due to the simple operating principle, sorting devices based on this method are ideally suited for paralellization.
Hardik J. Pandya, Kihan Park, Wenjin Chen, Marina A. Chekmareva, David J. Foran and Jaydev P. Desai
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00491H, Paper
MEMS-based flexible sensor for simultaneous electro-mechanical characterization of breast tissue for cancer diagnosis.
Chris Moraes, Joseph M Labuz, Yue Shao, Jianping Fu and Shuichi Takayama
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00722D, Paper
We designed a fabrication technique able to replicate microstructures in soft silicone materials (E < 1 kPa). Sugar-based ‘hard candy’ recipes from the confectionery industry were modified to be compatible...
Junqi Zhang, Rongxin Fu, Liping Xie, Qi Li, Wenhan Zhou, Ruliang Wang, Jiancheng Ye, Dong Wang, Ning Xue, Xue Lin, Ying Lu and Guoliang Huang
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00488H, Paper
A smart device for label-free and real-time detection of gene point mutations related diseases was developed based on the high dark phase contrast of vapor condensation. The main components of...
Li Lu, Jeffrey W. Schertzer and Paul R. Chiarot
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00520E, Paper
A flexible and reliable approach to continuously fabricate monodisperse, asymmetric vesicles that provides simultaneous control over the membrane unilamellarity, vesicle size, and luminal content.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00315F, Paper
Massively size-reduced, phase changeable, monodisperse perfluorocarbon (PFC) nanodroplets were generated for ultrasound medical imaging using condensation and dissolution of microfluidic-generated, cosolvent-incorporated PFC bubbles.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00589B, Paper
Label-free biomechanical readout for high-throughput phenotypic drug screening is achieved on bi-Content Contractility-based micro-Collagen Chip (3CChip).
Kidong Park, Ali Mehrnezhad, Elise A. Corbin and Rashid Bashir
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00444F, Technical Innovation
We demonstrate a novel optomechanical technique to characterize the stiffness of single adherent cells on a substrate in a non-invasive manner.
Gregor Czilwik, Thorsten Messinger, Oliver Strohmeier, Simon Wadle, Felix von Stetten, Nils Paust, Günter Roth, Roland Zengerle, Petri Saarinen, Jaana Niittymaki, Katherine McAllister, Orla Sheils, John J. O’Leary and Daniel Mark
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00591D, Paper
Diagnosis of infectious diseases suffers from long turnaround times for gold standard culture-based identification of bacterial pathogens, therefore impeding timely specific antimicrobial treatment based on laboratory evidence. Rapid molecular diagnostics-based...
Andreas Winkler, Stefan M Harazim, Siegfried B Menzel and Hagen Schmidt
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00756A, Paper
Surface acoustic wave (SAW) based fluid atomizers are ideally suited to generate micrometer-sized droplets without any moving parts or nozzles. Versatile application fields can be found for instance in biomedical,...
W. Espulgar, W. Aoki, T. Ikeuchi, D. Mita, M. Saito, J.-K. Lee and E. Tamiya
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00652J, Paper
Single-cell level drug profiling application of isolated single and groups of neonatal rat cardiomyocytes trapped by centrifugal force.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00611B, Critical Review
The liver, the largest organ in the human body, is a multi-functional organ with diverse metabolic activities that plays a critical role in maintaining the body and sustaining life. Although...
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00651A, Paper
We present a programmable microfluidic static droplet array (SDA) device that can perform user-defined multistep combinatorial protocols. It combines the passive storage of aqueous droplets without any external control with...
Rune Barnkob, Christian J. Kähler and Massimiliano Rossi
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00562K, Paper
The General Defocusing Particle Tracking (GDPT) is a 3D particle tracking method that relies on a simple empirical procedure based on a calibration image stack and the normalized cross-correlation function. The method is intuitive and easy to use and can be applied on defocused particle images of arbitrary shapes.
Mehrije Ferizi, Carolin Leonhardt, Christian Meggle, Manish K. Aneja, Carsten Rudolph, Christian Plank and Joachim O. Rädler
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00749F, Paper
Micro-structured arrays allow highly parallel assessment of single-cell mRNA-mediated dsGFP-expression time courses. Fits to the individual expression kinetics yield mRNA life-time distribution, which are compared for differently stabilized mRNA constructs.
Chee Meng Benjamin Ho, Sum Huan Gary Ng, King Ho Holden Li and Yong-Jin Yoon
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00685F, Critical Review
The term ‘‘Lab-on-a-Chip,’’ is synonymous to describing microfluidic devices with biomedical applications. Even though Microfluidics have been developing rapidly for the past decade, the uptake rate in biological research has...
Xinjie Zhang, Nan Xiang, Wenlai Tang, Di Huang, Xin Wang, Hong Yi and Zhonghua Ni
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00647C, Paper
This paper presents a novel passive flow regulator for steady and high-throughput inertial isolation of differently sized microbeads.
Ying Yi, Ulrich Buttner and Ian G. Foulds
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00703H, Paper
This work, focusing on an implantable drug delivery system, presents the first prototype electrolytic pump that combines a catalytic reformer and a cyclically actuated mode.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00558B, Paper
Primary, secondary and tertiary vortices generated inside an ion concentration polarization (ICP) region all rotating in the same direction.

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