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Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 6.115 24 Issues per Year Indexed in Medline
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Lidija Malic, Xuefeng F Zhang, Daniel Brassard, Liviu Clime, Jamal Daoud, Christian Luebbert, Virginie Barrere, Alex Boutin, Sabah Bidawid, Jeff Farber, Nathalie Corneau and Teodor Veres
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00852B, Paper
Infections caused by foodborne pathogens such as Listeria monocytogenes pose a threat to public health while timely detection is challenging due to pathogen low numbers. The development of robust and...
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00730E, Paper
Microdroplets and microcapsules have been widely produced using microfluidic flow-focusing junction for biomedical and chemical applications. However, the multiphase microfluidic flow at the flow-focusing junction has not been well investigated....
Jonathan Shemesh, Iman Jalilian Hassan Pour, Anthony Shi, Guan Heng Yeoh, Melissa Knothe Tate and Majid Ebrahimi Warkiani
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00633C, Critical Review
Transduction of mechanical forces and chemical signals affect every cell in the human body. Fluid flow in systems such as the lymphatic or circulatory systems modulates not only cell morphology,...
Hongxing Hu, David Eustace and Christoph A. Merten
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00686D, Technical Innovation
A novel approach for cell-based assays in droplets.
Jaekyung Koh, Chueh-Yu Wu, Harsha Kittur and Dino Di Carlo
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC90092A, Highlight
Injectable microporous gels formed from microfluidically-generated building blocks – Optofluidic fabrication of complex 3D particles using inertial flow sculpting – Scaling microparticle production with contact flow lithography.
Michael P. McRae, Glennon W. Simmons, Jorge Wong, Basil Shadfan, Sanjiv Gopalkrishnan, Nicolaos Christodoulides and John T. McDevitt
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00636H, Paper
The programmable bio-nano-chip (p-BNC) is an ultra-flexible system for multiplexed and multiclass assays on a universal modular lab-on-a-chip platform for clinical and bioscience applications at the point-of-care.
Masumi Yamada, Ayaka Hori, Sari Sugaya, Yuya Yajima, Rie Utoh, Masayuki Yamato and Minoru Seki
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00785B, Paper
Cell-sized, highly condensed collagen microparticles were produced, which were utilized to fabricate composite multicellular spheroids of primary hepatocytes.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00588D, Critical Review
This article reviews recent developments in miniaturized neural implants for optogenetics, highlights major improvements enabled by microtechnologies, and discusses challenges faced by developers and adopters of these new technologies.
John Wydallis, Rachel Feeny, William Wilson, Tucker Kern, Melissa M Reynolds, Tom Chen, Stuart Tobet and Charles Henry
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00778J, Paper
A high-density amperometric electrode array containing 8,192 individually addressable platinum working electrodes with an integrated potentiostat fabricated using Complementary Metal Oxide Semiconductor (CMOS) processes is reported. The array was designed...
Peijun J. W. He, Ioannis Katis, Robert W Eason and Collin Lawrence Sones
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00590F, Paper
We report the use of a new laser-based direct-write technique that allows programmable and timed fluid delivery in channels within a paper substrate which enables implementation of multi-step analytical assays....
Ye Tao, Assaf Rotem, Huidan Zhang, Connie B. Chang, Anindita Basu, Abimbola O. Kolawole, Stephan A. Koehler, Yukun Ren, Jeffrey S. Lin, James M. Pipas, Andrew B. Feldman, Christiane E. Wobus and David A. Weitz
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00556F, Paper
We developed a rapid, targeted and culture-free infectivity assay using high-throughput drop-based microfluidics. The high sensitivity and large dynamic range of our cost effective assay alleviates the need for serial dilution experiments.
Wenjie Wang, Chunhua Zhou, Tingting Zhang, Jingdong Chen, Shaoding Liu and Xudong Fan
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00847F, Paper
High-Q FP optofluidic laser array.
Yunpeng Zhao, Frank Schwemmer, Steffen Zehnle, Felix von Stetten, Roland Zengerle and Nils Paust
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00508F, Technical Innovation
Microparticles are widely used as solid phase for affinity based separation. Here, we introduce a new method for automated handling of microparticles in centrifugal microfluidics that is not restricted by...
Mayte Conejero-Muriel, Isaac Rodríguez-Ruiz, Sergio Martínez-Rodríguez, Andreu Llobera and Jose A. Gavira
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00776C, Paper
A Microfluidic chip for Cross-Linked of Enzyme Crystals (McCLEC) is presented and demonstrated to be a stable, reusable and robust biocatalyst-based device with very promising biotechnological applications. The cost-effective microfluidic...
Mark L. Porter, Joaquín Jiménez-Martínez, Ricardo Martinez, Quinn McCulloch, James William Carey and Hari S Viswanathan
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00704F, Paper
Microfluidic investigations of flow and transport in porous and fractured media have the potential to play a significant role in the development of future subsurface energy resource technologies. However, the...
Liqiang Ren, Yuchao Chen, Peng Li, Zhangming Mao, Po-Hsun Huang, Joseph Rufo, Feng Guo, Lin Wang, J. Philip McCoy, Stewart J. Levine and Tony Jun Huang
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00706B, Paper
We developed a standing surface acoustic wave (SSAW)-based cell sorting device. The throughput of our device has been significantly improved by using focused interdigital transducers (FIDTs) as SSAW generator.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00794A, Paper
The phase change caused by microparticles trapped on a waveguide is simulated and measured using a Young interferometer.
Mingcheng Yang, Rui Liu, Marisol Ripoll and Ke Chen
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00479A, Paper
An external diffusive mass flux is shown to be able to generate a mechanical torque to rotate a microscale turbine based on anisotropic diffusiophoresis.
Norhana Jusoh, Soojung Oh, Sudong Kim, Jangho Kim and Noo Li Jeon
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00698H, Communication
We propose three-dimensional microvascular networks in a hydroxyapatite-incorporated extracellular matrix for designing and manipulating a vascularized bone tissue model in a microfluidic device.
Jun Yang, P. Ravi Selvaganapathy, Travis J. Gould, Dhruva J. Dwivedi, Dingsheng Liu, Alison E. Fox-Robichaud and Patricia C. Liaw
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00681C, Paper
Microfluidic chip for rapid, reagent-free quantification of cell-free DNA in blood for severe sepsis prognostics.
Eileen Pedraza, Aleksandar Karajić, Matthieu Raoux, Romain Perrier, Antoine Pirog, Fanny Lebreton, Stéphane Arbault, Julien Gaitan, Sylvie Renaud, Alexander Kuhn and Jochen Lang
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00616C, Paper
We present a method for delivering cells to target electrodes of a whole-cell bioelectronic sensor for multi-parametric sensing of glucose and physiological hormone regulators.
Shi-Yang Tang, Yiliang Lin, Ishan D. Joshipura, Khashayar Khoshmanesh and Michael D. Dickey
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00742A, Paper
Low voltages can control the directional flow of EGaIn liquid metal in complex microfluidic networks via two complementary mechanisms.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00604J, Technical Innovation
A general method allowing the revival of ‘dead’ glass nanofluidic chips by a simple cycle of thermal treatments was presented.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00611B, Critical Review
The liver, the largest organ in the human body, is a multi-functional organ with diverse metabolic activities that plays a critical role in maintaining the body and sustaining life.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00716J, Critical Review
Suitable pumping methods for flow control remain a major technical hurdle in the path of biomedical microfluidic systems for point-of-care (POC) diagnostics. Vacuum-driven power-free micropumping method provides a promising solution...

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