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Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.748 24 Issues per Year Indexed in MEDLINE
 
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Zhou Liu, San To Chan, Faizi Hammad Ali, Robert C. Roberts and Ho Cheung Shum
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00177C, Paper
In this work, we investigate the coalescence of emulsion droplets in a controlled electric field. Two contacting droplets stabilized by surfactants can be forced to coalesce into a combined one...
 
Anthony K Au, Nirveek Bhattacharjee, Lisa F Horowitz, Tim C Chang and Albert Folch
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00126A, Paper
Microfluidic automation – the automated routing, dispensing, mixing, and/or separation of fluids through microchannels – generally remains a slowly-spreading technology because device fabrication requires sophisticated facilities and the technology’s use...
 
Sean Collignon, James R. Friend and Leslie Yeo
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C4LC01453G, Paper
Open droplet microfluidic platforms offer attractive alternatives to closed microchannel devices, including lower fabrication cost and complexity, significantly smaller sample and reagent volumes, reduced surface contact and adsorption, as well...
 
Flávio C. Cabrera, Antonio F. A. A. Melo, João C. P. de Souza, Aldo E. Job and Frank N. Crespilho
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01483A, Paper
The preparation of controlled amounts of magnetite nanoparticles decorated with gold nanoparticles without organic solvents, surfactants, or heat treatment is presented. For this, natural-rubber-based microfluidic device (NRMD) was used as a flexible lab-on-a-chip.
 
Larry J Millet, Joshua Lucheon, Robert F Standaert, Scott Thomas Retterer and Mitchel J Doktycz
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00094G, Paper
Biochemical separations are the heart of diagnostic assays and purification methods for biologics. On-chip miniaturization and modularization of separation procedures will enable the development of customized, portable devices for personalized...
 
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01377H, Paper
A multifunctional droplet microdevice was presented for the post-embryonic development study of C. elegans initiating from the L1 stage, and the effect of HIF-1 on worm development was investigated.
 
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01459F, Paper
A lab-on-a-chip system with integrated sample preparation and real-time loop-mediated isothermal amplification for rapid detection of Salmonella in food samples.
 
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01471E, Paper
Here, we present the development, characterization and quantification of a novel 1D/2D like polymeric platform for cell culture.
 
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00009B, Paper
Three-dimensional heterogeneous assembly of coded microgels in enclosed aquatic environments is demonstrated using a remotely actuated and controlled magnetic microgripper by a customized electromagnetic coil system.
 
Seung Chan Hong, Joon Sang Kang, Jung Eun Lee, Sang Soo Kim and Jae Hee Jung
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00079C, Paper
A novel microchannel-based inertial separator that can rapidly and continuously separate submicron aerosols according to particle inertial differences and Dean vortices in the airflow was developed.
 
Zhi-Jun Meng, Wei Wang, Xuan Liang, Wei-Chao Zheng, Nan-Nan Deng, Rui Xie, Xiao-Jie Ju, Zhuang Liu and Liang-Yin Chu
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00132C, Paper
Simple and versatile plug-n-play microfluidic systems that are fabricated from flexible assembly of glass-based flow-control modules are developed to flexibly manipulate flows for versatile emulsion generation.
 
Donghyuk Kim, Ivan Pushkarsky, Andy Tay and Dino Di Carlo
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC90032H, Highlight
Array-based discovery of multivalent aptamers – Aptamers for electrochemical sensing of TGF-β1 release from liver cells – Maintenance-free aptamer biosensor.
 
Yu-Chun Kung, Kuo-Wei Huang, Yu-Jui Fan and Pei-Yu Chiou
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01211A, Paper
We report a novel methodology for fabricating large-area, multilayer, thin-film, high aspect ratio, 3D microfluidic structures with through-layer vias and open channels that can be bonded between hard substrates.
 
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00044K, Technical Innovation
The combination of photolithography-patterning and embossing of a Parafilm® can fabricate microfluidic paper-based analytical devices (μPADs) without the use of a wax printer, cutter plotter and wet-chemical processing of paper.
 
P. T. Kumar, K. Vriens, M. Cornaglia, M. Gijs, T. Kokalj, K. Thevissen, A. Geeraerd, B. P. A. Cammue, R. Puers and J. Lammertyn
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01469C, Paper
We demonstrate the application of digital microfluidic technology as a suitable platform for conducting high-throughput cell-based studies on non-adherent yeast cells in a spatio-temporal manner.
 
Eunpyo Choi, Kilsung Kwon, Seung Jun Lee, Daejoong Kim and Jungyul Park
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01435A, Technical Innovation
An active micromixer having 3D nanochannel networks constructed from a spatially controlled nanoparticle assembly is proposed. It induces vortex generation due to non-equilibrium electrokinetics near the NCNM that allow a large effective interfacing area.
 
Christian Dusny, Alexander Grünberger, Christopher Probst, Wolfgang Wiechert, Dietrich Kohlheyer and Andreas Schmid
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01270D, Paper
The cross-platform comparison of three different single-cell cultivation methods demonstrates technical influences on biological key parameters like specific growth rate, division rate and cellular morphology.
 
Julian Marschewski, Stefan Jung, Patrick Ruch, Nishant Prasad, Sergio Mazzotti, Bruno Michel and Dimos Poulikakos
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00045A, Paper
Enhancing mixing is of uttermost importance in many laminar microfluidic devices, aiming at overcoming the severe performance limitation of species transport by diffusion alone. Here we focus on the significant...
 
Francesco Del Giudice, Hojjat Madadi, Massimiliano Maria Villone, Gaetano D' Avino, Angela Maria Cusano, Raffaele Vecchione, Maurizio Ventre, Pier Luca Maffettone and Paolo Netti
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00106D, Paper
The deflection of magnetic beads in a microfluidic channel through magnetophoresis can be improved if the particles are somehow focused along the same streamline in the device. We design and...
 
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C4LC01066C, Paper
Catalysis in microreactors allows reactions to be performed in a very small volume, reducing the environmental problems and greatly intensifying the processes through easy pressure control and the elimination of...
 
Xiaolong Luo, Chen-Yu Tsao, Hsuan-Chen Wu, David N. Quan, Gregory F. Payne, Gary W. Rubloff and William E. Bentley
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00107B, Paper
The human gut is over a meter in length, liquid residence times span several hours.
 
Daniel Taller, Katherine Richards, Zdenek Slouka, Satyajyoti Senapati, Reginald Hill, David B. Go and Hsueh-Chia Chang
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00036J, Paper
A novel approach to the analysis of exosomal RNA is presented using SAW exosome lysis and ion-exchange nanomembrane RNA sensing.
 
Chun-Li Chang, Wanfeng Huang, Shadia I. Jalal, Bin-Da Chan, Aamer Mahmood, Safi Shahda, Bert H. O'Neil, Daniela E. Matei and Cagri A. Savran
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00100E, Paper
A parallel flow micro-aperture chip system for detection of circulating tumor cells.
 
Elisabeth Wilhelm, Kaustubh Deshpande, Frederik Kotz, Dieter Schild, Nico Keller, Stefan Heissler, Kai Sachsenheimer, Kerstin Länge, Christiane Neumann and Bastian. E. Rapp
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01440E, Paper
New surface modification techniques enable room temperature bonding of epoxy components to PDMS.
 
Fernando Martinez-Pedrero, Arthur V. Straube, Tom H. Johansen and Pietro Tierno
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00067J, Paper
Sorting in motion: magnetic colloids driven above a channel-free magnetic substrate can be readily assembled into one-dimensional chains capable of performing sophisticated lab-on-a-chip functions, including trapping, sorting and tweezing.
 

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