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Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.748 24 Issues per Year Indexed in Medline
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Shih-Mo Yang, Dapeng Zhang, Wang Chen and Shih-Chi Chen
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00448A, Paper
Crystallization is one of the most crucial steps in the process of pharmaceutical formulation. In recent years, emulsion-based platforms have been developed and broadly adopted for generating high quality products....
Berrak Gol, Francisco J. Tovar-Lopez, Michael E. Kurdzinski, Shi-Yang Tang, Phred Petersen, Arnan Mitchell and Khashayar Khoshmanesh
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00415B, Paper
This work presents a microfluidic chip, which integrates continuous generation of micro scale galinstan droplets in glycerol, and the hydrodynamic transfer of these droplets into sodium hydroxide (NaOH) solution.
Mikael Evander, Olof Gidlöf, Björn Olde, David Erlinge and Thomas Laurell
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00290G, Paper
An acoustic non-contact method for extracting platelet-derived microparticles from small plasma volumes is presented. The method has higher recovery and can handle smaller sample volumes than conventional differential centrifugation method. It is optimal for the analysis of precious biobank samples with limited volume.
A. Liga, A. D. B. Vliegenthart, W. Oosthuyzen, J. W. Dear and M. Kersaudy-Kerhoas
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00240K, Frontier
This review enables biologists and clinicians to assess the performance of microfluidics, and microfluidic engineers to discover these promising biomarkers.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01316F, Paper
A high-throughput microfluidic single-cell screening platform capable of investigating cell properties, such as growth and biomolecule production, followed by selectively extracting particular cells of interest off-chip for further study is developed.
Jens Höfflin, Saraí Torres Delgado, Fralett Suárez Sandoval, Jan G. Korvink and Dario Mager
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00138B, Technical Innovation
We present a design for wireless power transfer, via inductively coupled coils, to a spinning disk. The rectified and stabilised power feeds an Arduino-compatible microcontroller on the disc, which in...
Fan Xu, Ruogang Zhao, Alan S. Liu, Tristin Metz, Yu Shi, Prasenjit Bose and Daniel Henry Reich
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C4LC01395F, Paper
This paper describes an approach to actuate magnetically arrays of microtissue constructs for long-term mechanical conditioning and subsequent biomechanical measurements. Each construct consists of cell/matrix material self-assembled around a pair...
Youchun Xu, He Yan, Yan Zhang, Kewei Jiang, Ying Lu, Yonghong Ren, Hui Wang, Shan Wang and Wanli Xing
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00244C, Paper
Multiplex PCR is an effective tool for simultaneous multiple target detection but is limited by the intrinsic interference and competition among primer pairs when it is performed in one reaction...
Jinzhen Fan, Baoqing Li, Siyuan Xing and Tingrui Pan
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00432B, Paper
This paper reports a reconfigurable microfluidic dilution device for high-throughput quantitative assays, which can easily produce discrete logarithmic/binary concentration profiles ranging from 1 to 100 fold dilution in parallel from...
Faride Haghighi, Zahra Talebpour and Amir Sanati-Nezhad
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00283D, Critical Review
In recent years, the need of measurement and detection of samples in situ or with very small volume and low concentration (low sub parts per billion) is a cause for...
Matthew M. Shindel and Eric M. Furst
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00351B, Paper
Coupling analog frequency modulation (FM) to the driving stimulus in active microrheology measurements conducted with optical tweezers effectively parallelizes numerous single-frequency experiments.
Xiaojun Yan, Jingyu Wang, Lu Zhu, Jonathan Joseph Lowrey, Yuanyuan Zhang, Wei Hou, Jiahong Dong and Yanan Du
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00313J, Paper
Hydrogel as three-dimensional (3D) substrate has been employed in miniaturized high throughput protein detection platforms to increase number of effective antibodies and signal augmentation. However, high water content of hydrogel...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01052C, Focus
The purpose of this article is to demonstrate the capacity of paper-based ELISA (P-ELISA) to monitor VEGF in patients requiring treatment for vision-threatening diseases.
Simon Garcia, Raimon Sunyer, Andy Olivares, Jérôme Noailly, Javier Atencia and Xavier Trepat
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00140D, Paper
Cellular responses to chemical cues are at the core of a myriad of fundamental biological processes ranging from development to cancer metastasis. Most of these biological processes are also influenced...
A. Zacheo, A. Zizzari, E. Perrone, L. Carbone, G. Giancane, L. Valli, R. Rinaldi and V. Arima
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01419G, Technical Innovation
Microwave-assisted wet etching intensifies the glass etching action under safe working and finely monitored operative conditions and it produces smooth deep channels in short processing times with reduced underetching effects.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00235D, Critical Review
Inkjet printing is emerging at the forefront of biosensor fabrication technologies. Parallel advances in both ink chemistry and printers have led to a biosensor manufacturing approach that is simple, rapid,...
Xixian Wang, Rui Hu, Anle Ge, Liang Hu, Shanshan Wang, Xiaojun Feng, Wei Du and Bifeng Liu
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00354G, Paper
C. elegans as a powerful model organism, has been widely used in fundamental biological studies. Many of these studies frequently need a large number of different stage-synchronized worms due to...
Robert R. Niedl and Carsten Beta
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00276A, Paper
Responsive hydrogels serve as controllable on-chip fluid reservoirs that drive the operation of paper-based microfluidic devices.
Tran Quang Hung, Yi Sun, Carl Esben Poulsen, Than Linh-Quyen, Wai Hoe Chin, Dang Duong Bang and Anders Wolff
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00176E, Paper
We developed a lab-on-a-chip system integrating miniaturized micro-optic SAF arrays within microfluidic chambers for high sensitivity and multiplexed detection of fluorescent molecules.
Jiajie Chen, Zhiwen Kang, Guanghui Wang, Fong-Chuen Loo, Siu-Kai Kong and Ho-Pui Ho
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00406C, Paper
We present a versatile optofluidic flow manipulation scheme based on plasmonic heating in random gold nanoisland substrate (Au-NIS). With its highly efficient conversion of optical power to hydrodynamic actuation, the...
Friedrich Schuler, Frank Schwemmer, Martin Trotter, Simon Wadle, Roland Zengerle, Felix von Stetten and Nils Paust
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00291E, Paper
Aqueous microdroplets provide miniaturized reaction compartments for numerous chemical, biochemical or pharmaceutical applications. We introduce centrifugal step emulsification for the fast and easy production of monodispers droplets. Homogenous droplets with...
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00379B, Paper
We present a novel microfluidic EDGE (Edge based Droplet GEneration) device with regularly spaced micron-sized partitions, which is aimed at upscaling of o/w emulsion preparation. By this means, remarkably higher...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00217F, Paper
Simple microfluidic flow focusing generation of droplets from ultralow interfacial tension aqueous two phase systems (ATPS).
Yingnan Sun, Xiaodong Chen, Xiaoguang Zhou, Jinbiao Zhu and Yude Yu
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00356C, Paper
We introduce a new model to describe the multiple printing procedure implemented by the inkjet printing approach. This non-contact and sequential picoliter droplet printing technology is named as sequential inkjet printing.
David J. Guckenberger, Theodorus E. de Groot, Alwin M. D. Wan, David J. Beebe and Edmond W. K. Young
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00234F, Tutorial Review
Micromilling is a fast and simple method capable of fabricating complex 2D or 3D microdevices compatible with cell culture and microscopy.

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