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Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.748 24 Issues per Year Indexed in MEDLINE
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Edinson Lucumi Moreno, Siham Hachi, Sebastiaan J Trietsch, Aidos S Baumuratov, Thomas Hankemeier, Paul Vulto, Jens C Schwamborn and Ronan M.T. Fleming
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00180C, Paper
A hallmark of Parkinson's disease is the progressive loss of nigrostriatal dopaminergic neurons. We derived human neuroepithelial cells from induced pluripotent stem cells and sucessfully differentiated them into dopaminergic neurons...
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C4LC01409J, Paper
Microfluidic deterministic lateral displacement (DLD) arrays have been applied for fractionation and analysis of cells in quantities of ~100 µL of blood, with processing of larger quantities limited by clogging...
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00306G, Paper
A novel method to study the condensed phase reactions that occur during the ignition of hypergolic propellants (very fast liquid reactions) using microreactors is presented. Planar counterflow microreactors are used...
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00239G, Frontier
Cell-containing hydrogel modules, as cell–hydrogel microunits for creating a physiologically relevant 3D in vivo-like microenvironment with multiple cell types and unique extracellular matrix (ECM) compositions, facilitate long-term cell maintenance and...
Renee M Huval, Oliver H Miller, Jabe Lowry Curley, Yuwei Fan, Benjamin J Hall and Michael Moore
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C4LC01513D, Paper
The use of advanced in vitro testing is a powerful tool to develop predictive cellular assays suitable for improving the high attrition rates of novel pharmaceutical compounds. A microscale, organotypic...
Josiane P. Lafleur, Silja Senkbeil, Jakub Novotny, Gwenaël Nys, Nanna Bøgelund, Kasper D. Rand, Frantisek Foret and Jorg P Kutter
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00224A, Paper
A novel, rapid and simple method for the preparation of emulsion-templated monoliths in microfluidic channels based on thiol-ene chemistry is presented. The method allows monolith synthesis and anchoring inside thiol-ene...
Daniel E. Heath, Abdul Rahim Mohamed Sharif, Chee Ping Ng, Mary G. Rhoads, Linda G. Griffith, Paula T. Hammond and Mary B. Chan-Park
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01416B, Paper
Micromolded hydrogels lose non-fouling properties enabling cell adhesion and migration on the gel (left). We develop a method to regenerate the cell resistance of the gels resulting in robust resistance to cell adhesion (right).
Emanuel Elizalde, Raúl Urteaga and Claudio L. A. Berli
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01487A, Paper
We present a tool that allows one to determine the cross-sectional profile required for a programmed liquid front velocity or flow rate during lateral imbibition in paper substrates. New regimes can be designed, i.e. constant liquid front velocity.
Julien Autebert, Benoit Coudert, Jérôme Champ, Laure Saias, Ezgi Tulukcuoglu Guneri, Ronald Lebofsky, François-Clément Bidard, Jean-Yves Pierga, Françoise Farace, Stéphanie Descroix, Laurent Malaquin and Jean-Louis Viovy
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00104H, Paper
A new generation of the Ephesia cell capture technology optimized for CTC capture and genetic analysis is presented, characterized in depth and compared with the CellSearch system as a reference.
BingPu Zhou, Wei Xu, Ahad Syed, Yeungyeung Chau, Longqing Chen, Basil Chew, Omar Yassine, Xiaoxiao Wu, Yibo Gao, Jingxian Zhang, Xiao Xiao, Jurgen Kosel, Xixiang Zhang, Zhaohui Yao and Weijia Wen
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00173K, Paper
Magnetically functionalized PDMS-based micropillar arrays have been successfully designed, fabricated and implanted for controllable microfluidic mixing. The arrangement of PDMS micropillar arrays inside the microchannel can be flexibly controlled by...
Vincent Miralles, Axel Huerre, Hannah Williams, Bastien Fournié and Caroline Jullien
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00110B, Paper
We report on a versatile technique for microfluidic droplet manipulation that proves
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00175G, Method
To better understanding fluid dynamics within microfluidic channels, herein, we present an accurate experimental approach for studying the fluid dynamics of rapid processes within microfluidic devices using bright-field microscopy with white light illumination.
Z. G. Li, S. Xiong, L. K. Chin, K. Ando, J. B. Zhang and A. Q. Liu
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00048C, Paper
The paper reports the tensile strength measurement using an optofluidic chip based on the displacement of air–water interface deformation with homogeneous nucleation.
MOHAMED LEMINE YOUBA DIAKITE, Jérôme ROLLIN, Dorothee Jary, Jean Berthier, Chantal MOURTON-GILLES, Didier Sauvaire, Cathy PHILIPPE, Guillaume Delapierre and Xavier Gidrol
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00178A, Paper
A long-sought milestone in the defense against bioterrorism is the development of rapid, simple, and near-patient assays for diagnostic and theranostic purposes. Here, we present a powerful test based-on a...
A. Causier, G. Carret, C. Boutin, T. Berthelot and P. Berthault
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00193E, Paper
A microbubble pump built by 3D printing ensures efficient dissolution of hyperpolarized gaseous species for micro-sized NMR.
Kazuya Fujimoto, Moeto Nagai, Hirofumi Shintaku, Hidetoshi Kotera and Ryuji Yokokawa
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00148J, Paper
Here, we propose a microtubule-based transport system between separate compartments in a microfluidic device, which dynamically forms single-micrometre-scale channels.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00041F, Paper
Textile weaving is presented as a new, highly scalable and affordable route for fabrication of electrochemical sensors.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00174A, Technical Innovation
We demonstrate ultrasonic welding for (1) self-aligned gapless bonding of a two-part lab-on-a-chip system and for (2) bonding of a large area shallow chamber. Combining injection moulding using micromilled shims with ultrasonic welding, we can go from design to a batch of chips within a single day. The chips are mass-producible with a total production time of 60 s per chip.
Zhaoyi Wang, Danut Voicu, Ling Tang, Li Wei and Eugenia Kumacheva
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00241A, Paper
Adsorption of polymers from solutions moving past solid or liquid surfaces controls a broad range of phenomena in science, technology, and medicine. In the present work, a microfluidic methodology was...
Janay Elise Kong, Jaekyung Koh, Jonathan Lin and Dino Di Carlo
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC90037A, Highlight
Microfluidic smartphone accessory for immunosurveillance – Intraocular microfluidic pressure sensor – Implanted iontophoretic delivery of chemotherapy.
Vittorio Bianco, Melania Paturzo, Valentina Marchesano, Ivan Gallotta, Elia Di Schiavi and Pietro Ferraro
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00143A, Paper
Simple and effective imaging strategies are of utmost interest for application at lab-on-chip scale. In fact, the majority of diagnostics tools are still image-based approaches for medical as well as...
Maria Antfolk, Christian Antfolk, Hans Lilja, Thomas Laurell and Per Augustsson
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00078E, Paper
Metastatic disease is responsible for most cancer deaths, and hematogenous spread through circulating tumor cells (CTC) is a prerequisite for tumor dissemination. CTCs may undergo epithelial-mesenchymal transition where many epithelial...
yukun ren, Weiyu Liu, Yankai Jia, Ye Tao, Jinyou Shao, Yucheng Ding and Hongyuan Jiang
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00058K, Paper
Position-controllable trapping of particles on the surface of a bipolar metal strip by induced-charge electroosmotic (ICEO) flow is presented herein. We demonstrate a nonlinear ICEO slip profile on the electrode...
J. R. Buser, A. Wollen, E. K. Heiniger, S. A. Byrnes, P. C. Kauffman, P. D. Ladd and P. Yager
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00080G, Technical Innovation
Portable lysis of Mycobacterium marinum and Staphylococcus epidermidis bacteria using an mp3 player, electromagnetic coil, and magnet in a tube.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01212G, Paper
Micropores in the ultra-thin parylene membrane limit myocyte–nonmyocyte interactions without transmembrane cell migration. Microelectrodes record field potentials for computing electrical conduction of the myocyte layer.

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