Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.697 24 Issues per Year Indexed in MEDLINE
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Samad Ahadian, Shukuyo Yamada, Javier Ramon, Kosuke Ino, Hitoshi Shiku, Ali Khademhossein and Tomokazu Matsue
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00479E, Communication
In this manuscript we demonstrate the rapid formation of three-dimensional (3D) embryonic stem cell (ESC) aggregates with controllable sizes and shapes in hydrogels using dielectrophoresis (DEP). The ESCs encapsulated within...
Shaohua Ma, Joseph M Sherwood, Wilhelm Huck and Stavroula Balabani
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00671B, Paper
The flow topology in moving microdroplets has a significant impact on the behaviour of encapsulated objects and hence on applications of the technology. This study reports on a systematic investigation...
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00609G, Paper
We present a novel method for the determination of aliquot volumes on rotating centrifugal microfluidic platforms using image segmentation.
Chueh-Yu Wu, Oladunni Adeyiga, Jonathan Lin and Dino Di Carlo
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC90067G, Highlight
Electrokinetic concentration on paper – Two-phase in flow concentration on paper – Laser micromachined hybrid open/paper microfluidic chips.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC90072C, Editorial
From themed collection Lab on a Chip: Insights Issue
George Whitesides, the Chair of the Editorial Board of Lab on a Chip, introduces this year’s “Insights” themed issue.
Tríona M. O’Connell, Damien King, Chandra K Dixit, brendan o'connor, Dermot Walls and Jens Ducree
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00618F, Paper
It is now widely recognised that the earliest changes that occur on a cell when it is stressed or becoming diseased are alterations in its surface glycosylation. Current state-of-the-art technologies...
Lina Wei, Andrew J. Sweeney, Liyuan Sheng, Yu Fang, Mark S. Kindy, Tingfei Xi and Bruce Z. Gao
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00723A, Paper
The single-neuron biochip created by the microfluidics-based laser guided cell-micropatterning system demonstrates high sensitivity in evaluation of the developmental neurotoxicity.
Lyderic Bocquet and Patrick Tabeling
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00325J, Frontier
From themed collection Lab on a Chip: Insights Issue
Cartoon representing the main mechanisms that operate in the nano-, micro- and millifluidic realms. The mechanisms are illustrated by characters whose positions in the spectrum of scales are fixed by the characteristic lengths they are associated with. The fundamental questions of nanofluidics are the following: How do the characteristic scales pertaining to the 1–100 nm range interfere with the system size? Can they combine together to produce new physical effects?
Bruno Pinho, Stéphane Girardon, Frédéric Bazer-Bachi, Ghislain Bergeot, Samuel Marre and Cyril Aymonier
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00505H, Paper
In this work, we present a novel microfluidic-based approach for investigating thermodynamics of multicomponents systems at high pressures and temperatures, such as determining miscibility diagrams and supercritical coordinates of complex...
Chia-Wen Chang, Yung-Ju Cheng, Melissa Tu, Ying-Hua Chen, Chien-Chung Peng, Wei-Hao Liao and Yi-Chung Tung
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00732H, Paper
This paper reports a polydimethylsiloxane-polycarbonate (PDMS-PC) hybrid microfluidic device capable of performing cell culture under combinations of chemical and oxygen gradients. The microfluidic device is constructed by two PDMS layers...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00676C, Paper
From themed collection 2014 Lab on a Chip Emerging Investigators
It is increasingly recognized that infiltrating immune cells contribute to the pathogenesis of a wide range of solid tumors. The paracrine signaling between tumor and the immune cells alters the...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00662C, Paper
Developing blood-based test is appealing for non-invasive disease diagnosis, especially when biopsy is difficult, costly, and sometime not even an option. Tumor-derived exosomes have attracted increasing interest for non-invasive cancer...
Daniel Stoecklein, Chueh-Yu Wu, Keegan Owsley, Yu Xie, Dino Di Carlo and Baskar Ganapathysubramanian
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00653D, Paper
The ability to control the shape of a flow in a passive microfluidic device enables potential applications in chemical reaction control, particle separations, and complex material fabrication. Recent work has...
Kosuke Iwai, Kuan-Cheng Shih, Xiao Lin, Thomas A. Brubaker, Ryan Daniel Sochol and Liwei Lin
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00500G, Paper
Point-of-care (POC) and disposable biomedical applications demand low-power microfluidic systems with pumping components that provide controlled pressure sources. Unfortunately, external pumps have hindered the implementation of such microfluidic systems due...
Micha Haim Kornreich, Michael Heymann, Seth Fraden and Roy Beck
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00600C, Technical Innovation
We visualize birefringence in $\mu$L sample volumes using a microfluidic dialysis chip optimized for cross polarization microscopy. The chip is composed of two overlapping Polydimethylsiloxane (PDMS) channels separated by a...
Anthony Dickherber, Brian Sorg, Rao Divi, Aniruddha Ganguly and Miguel Ossandon
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC90059F, Editorial
Extraordinary progress has been made in the last several decades in basic and clinical cancer research, but an urgent need persists for better tools that can accelerate our ability to understand and combat cancer.
Adrien Bussonnière, Yannick Miron, Michaël Baudoin, Olivier Bou Matar, Michel Grandbois, Paul Charette and Alan Renaudin
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00625A, Paper
We present a droplet-based surface acoustic wave (SAW) system designed to viably detach biological cells from a surface and sort cell types based on differences in adhesion strength (adhesion contrast).
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00588K, Paper
We describe a versatile microfluidic fluorescence-activated cell sorter that uses acoustic actuation to sort cells or drops at ultra-high rates.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00617H, Tutorial Review
This short review focuses on the application of SU-8 for the microchip-based approach to the miniaturization of mass spectrometry.
Wei-Lun Hsu, Dalton J. E. Harvie, Malcolm R. Davidson, Helen Jeong, Ewa M. Goldys and David W. Inglis
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00504J, Paper
Concentration gradient focusing and separation in a silica nanofluidic channel with a non-uniform electroosmotic flow.
Benjamín Vazquez, Naser Qureshi, Laura Oropeza-Ramos and Luis F. Olguin
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00654B, Paper
Using a split laser, we analysed how the velocity of in-flow microdroplets modifies the droplet fluorescence signal when interrogated by LIF.
Gilad Kaufman, Rostislav Boltyanskiy, Siamak Nejati, Abdou R. Thiam, Michael Loewenberg, Eric R. Dufresne and Chinedum O. Osuji
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00482E, Communication
A single-step method is introduced to generate microcapsules with 1–2 μm thick shells and tunable mechanical properties based on polyelectrolyte complexation across a water/oil droplet interface.
Luoran Shang, Yao Cheng, Jie Wang, Haibo Ding, Fei Rong, Yuanjin Zhao and Zhongze Gu
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00698D, Communication
A microfluidic device with an annular capillary array injection channel was developed for single-step emulsification of multicomponent double emulsions.
Gunnar Bergström, Kjell Nilsson, Carl-Fredrik Mandenius and Nathaniel D. Robinson
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00693C, Communication
Macroporous gelatin beads (CultiSpher™ microcarriers) provide a convenient method for rapidly and reliably introducing cells cultured ex situ into a microfluidic device, where the spheres create a 3D environment for...
Issac. J. Micheal, Aditya J. Vidhyasagar, Kiran Kumar Bokara, Naveen Kumar Mekala, Amit Asthana and Ch. Mohan Rao
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00659C, Technical Innovation
We present a simple, rapid, bench-top, Foil Assisted Rapid Molding (FARM) method for fabrication of microfluidic devices. This novel technique involves the use of aluminium foil, pen and an X-Y...

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