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Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.748 24 Issues per Year Indexed in Medline
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Aubrey Emmanuel Kusi-Appiah, Troy Lowry, Emily M Darrow, Korey Wilson, Michael Davidson , Brian P Chadwick and Steven Lenhert
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00478K, Paper
The dose-dependent bioactivity of small molecules on cells is a crucial factor in drug discovery and personalized medicine. Although small-molecule microarrays are a promising platform for miniaturized screening, it has...
Melis Hazar, Yong Tae Kim, Jiho Song, Philip R. LeDuc, Lance A. Davidson and William C. Messner
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00530B, Paper
To investigate the collective movements within 3D multilayered tissues our group has focused on developing a novel microfluidic technique capable of creating complex patterns in multicellular structures.
F. Schwemmer, T. Hutzenlaub, D. Buselmeier, N. Paust, F. von Stetten, D. Mark, R. Zengerle and D. Kosse
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00513B, Paper
The centrifugo-pneumatic multi-liquid aliquoting allows for parallel aliquoting of two liquids and pairwise combination of generated aliquots.
David Dannhauser, Domenico Rossi, Filippo Causa, Pasquale Memmolo, ANDREA FINIZIO, Thomas Wriedt, Jens Hellmers, Yuri Eremin, Pietro Ferraro and Paolo Netti
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00525F, Paper
A camera-based light scattering approach coupled with a viscoelasticity-induced cell migration technique has been used to characterize morphological properties of erythrocytes in microfluidic flows. We have obtained light scattering profiles...
Ryo Murakami, Chia-Hung Dylan Tsai, Makoto Kaneko, Shinya Sakuma and Fumihito Arai
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00535C, Paper
An unexpected phenomenon of red blood cell bouncing back and forth between the walls inside a microfluidic channel was observed during experiments, and is presented as ``Cell Pinball" in this...
Fabienna Arends, Sabine Sellner, Philipp M. Seifert, Ulrich Gerland, Markus Rehberg and Oliver Lieleg
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00561B, Paper
For an efficient distribution of drugs and drug carriers through biological barriers such as the vascular system, the size and surface properties of nanoparticles and molecules play a key role....
Gunnar Bergström, Jonas Christoffersson, Kristin Schwanke, Robert Zweigerdt and Carl-Fredrik Mandenius
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00449G, Paper
We exploit the use of 3D clustered cardiac bodies (CBs) as a novel tool for toxicity testing in microfluidics.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00431D, Paper
We investigate the hydrodynamics of gas/liquid and liquid/liquid flows in the post microreactor with flow visualization and CFD simulation, and reveal the mechanism of mass transfer enhancement compared to open channels through transport analysis.
Mehdi Ghodbane, Elizabeth C. Stucky, Tim J. Maguire, Rene S. Schloss, David I. Shreiber, Jeffrey D. Zahn and Martin L. Yarmush
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00398A, Paper
We develop and validate a 6-plex microfluidic immunoassay with 32-sample capacity, high performance sensitivity, and a large dynamic range.
Yiwei Li, Xiaojun Feng, Yachao Wang, Wei Du, Peng Chen, Chao Liu and Bi-Feng Liu
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00618J, Paper
A simple and versatile 3D microfluidic strategy, enabling directed assembly of multiple gradients in cell density with user-defined designs for reconstitution of the functionality of tissues and cell density-dependant nano-cytotoxicity assay.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00436E, Paper
We demonstrate 3D ultrasound cell culture for the formation of solid liver tumors in a multi-well microplate, and we use this method to simulate the early stages of tumor development under immune natural killer cell attack.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00688K, Paper
Cell membrane water permeability is an important determinant of epithelial fluid secretion, tissue swelling, angiogenesis, tumor spread and other biological processes. Cellular water channels, the aquaporins, are important drug targets....
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00529A, Paper
Quantitative assays are of great importance for point-of-care (POC) diagnostics because they can offer accurate information on the analytes. However, current POC devices often require an accessory instrument to give...
Mathias Ohlin, Ida Iranmanesh, Athanasia E Christakou and Martin Wiklund
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00490J, Paper
We study the temperature-independent impact on cell viability of relevant physical parameters during long-term, high-acoustic-pressure ultrasonic exposure in a microfluidic chip designed for ultrasonic-standing-wave trapping and aggregation of cells. We...
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00573F, Technical Innovation
Carbon nanotubes (CNT) have been extensively used to produce electrodes of enhanced performance but only very recently exploited in microfluidic devices. In these cases, CNT-electrodes had to be produced previous...
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00465A, Paper
Paper-based microfluidic devices have recently attracted attention for their ability to utilize the inherent capillary force, or absorptivity, of paper to generate flows instead of requiring an external force. This...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00343A, Paper
This work introduces a new numerical simulation approach to acoustic microfluidic chip design based on coupled-resonator theory.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00090D, Paper
We present an innovative electrode design which uses multi-range electrokinetics with impedance spectroscopy, reaching a detection limit of 105 CFU mL−1 of bacteria.
Sydney M. Shaffer, Rohan P. Joshi, Benjamin S. Chambers, David Sterken, Andrew G. Biaesch, David J. Gabrieli, Yang Li, Kristen A. Feemster, Scott E. Hensley, David Issadore and Arjun Raj
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00459D, Paper
This paper presents an automated platform for ultra rapid detection of respiratory viruses using RNA FISH.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00626K, Paper
Spatially-controlled plasma treatment enables easy, accurate, reliable and scalable wettability patterning of microfluidic devices.
Lingqian Chang, Daniel Gallego-Perez, Xi Zhao, Paul Bertani, Zhaogang Yang, Chi-Ling Chiang, Veysi Malkoc, Junfeng Shi, Chandan K. Sen, Lynn Odonnell, Jianhua Yu, Wu Lu and L. James Lee
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00553A, Paper
Dielectrophoresis-assisted nanochannel electroporation for controlled large scale cell transfection.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00544B, Paper
Sandstone formations are ubiquitous to both aquifers and petroleum reservoirs, of which clay is a major constituent. The release of clay particles from pore surfaces as a result of reduced...
M. D. Simmons, N. Jones, D. J. Evans, C. Wiles, P. Watts, S. Salamon, M. Escobar Castillo, H. Wende, D. C. Lupascu and M. G. Francesconi
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00287G, Paper
The first example a doped ionic solid with increasing content of dopant prepared in a microreactor.
Oladunni Adeyiga, Soroush Kahkeshani, Petra Paiè and Dino Di Carlo
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC90071A, Highlight
One microstructure to repel them all – Capillarity-guided micropatterning – Droplets chasing droplets.
Luis Fernando Alonzo, Monica L Moya, Venktesh S Shirure and Steven C George
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00507H, Paper
Tissue engineering can potentially recreate in vivo cellular microenvironments in vitro for an array of applications such as biological inquiry and drug discovery. However, the majority of current in vitro...

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