Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.697 24 Issues per Year Indexed in MEDLINE
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Yan Pang, Hyoungsoo Kim, Zhaomiao Liu and Howard A. Stone
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00871E, Paper
We study the effect of softness of the microchannel on the process of droplet generation in two-phase flows in a T-junction microchannel.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00716F, Paper
A simple paper fluidic device provides a visual indication of blood coagulation status.
Joshua J. Cardiel, Ya Zhao, Lige Tonggu, Liguo Wang, Jae-Hyun Chung and Amy Q. Shen
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00610K, Communication
Schematics of microfluidic-assisted GOx immobilization in a nanogel scaffold with chronoamperometric studies for glucose sensing.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00587B, Paper
An integrated microfluidic system was developed for automatic, high-throughput screening of multiple cell lines to competitively select aptamer-based biomarkers for ovarian cancer cells.
Wuzhou Song, Demetri Psaltis and Kenneth B. Crozier
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00477A, Communication
We present a micro-patterned silicon structure that enables the preparation of a SERS substrate and pre-concentration of the analyte molecules.
YongAn Huang, Yezhou Wang, Lin Xiao, Huimin Liu, Wentao Dong and Zhouping Yin
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00762J, Paper
This paper describes the design and characterization of microfluidic serpentine antennas with reversible stretchability and designed mechanical frequency modulation (FM).
S. Focaroli, S. Mazzitelli, M. Falconi, G. Luca and C. Nastruzzi
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00679H, Paper
The present paper describes the production of microfluidic chips using an approach based on shrinkable biocompatible polymers (i.e. agarose) for the production of size controlled microfluidic channels.
Yuanjun Yan, Li Fang Ng, Li Theng Ng, Kwan Bum Choi, Jan Gruber, Andrew A. Bettiol and Nitish V. Thakor
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00494A, Paper
We present a high-throughput continuous-flow C. elegans sorting device that works based on integrated optical fiber detection and laminar flow switching.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC90079K, Highlight
PCR-activated cell sorting in microdroplets – Microfluidic single-cell western blots – Microwells reveal the functional heterogeneity in single circulating tumor cells.
Cheuk-Wing Li, Guodong Yu, Jingyun Jiang, Simon Ming-Yuen Lee, Changqing Yi, Wanqing Yue and Mengsu Yang
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00779D, Paper
Through utilizing streamline reversibility, we developed a microfluidic device for the continuous separation of free ligands from a protein–ligand complex for off-chip detection.
Hidehiro Oana, Kaori Nishikawa, Hirotada Matsuhara, Ayumu Yamamoto, Takaharu G. Yamamoto, Tokuko Haraguchi, Yasushi Hiraoka and Masao Washizu
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC90085E, Correction
Joshua W. Griffis, Mikhail M. Safranovitch, Shilpi P. Vyas, Sean Gerrin, Ekaterina Protozanova, Gene Malkin and Robert H. Meltzer
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00781F, Paper
Single molecule DNA intercalation in continuous elongational flow.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00424H, Paper
We present a unique method to instruct in the specific art of droplet formation using a hand-operated pressure pumping system and simple droplet generators, allowing students to form monodisperse picoliter to nanoliter droplet streams at low cost.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00739E, Paper
A microfabricated optofluidic ring resonator (μOFRR) sensor is introduced and its utility as a detector for micro-scale gas chromatography is assessed.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00700J, Paper
We present a pressure-tolerant 3D parallel polyimide (PI) film microreactor operating at up to ~160 bars with direct 3D flow focusing geometry for mass production of PEG–PLGA nanoparticles in a ~101 gram-scale (g h−1).
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00443D, Paper
Considerable effort has recently been directed toward the miniaturization of quantitative-polymerase-chain-reaction (qPCR) instrumentation in an effort to reduce both cost and form factor for point-of-care applications. Considerable gains have been...
Maulik V. Patel, Imaly A. Nanayakkara, Melinda G. Simon and Abraham P. Lee
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00447G, Paper
We report on a microfluidic platform that performs simultaneous on-chip pumping and size based separation of cells and particles.
Roman Gerbers, Wilke Foellscher, Hong Chen, Constantine Anagnostopoulos and Mohammad Faghri
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00786G, Paper
Currently, the Lateral flow Immunoassays (LFIAs) are not able to perform complex multi-step immunodetection tests because of their in inability to introduce multiple reagents in a controlled manner to the...
Jérémie Léonard, Norbert Dumas, Jean-Pascal Caussé, Sacha Maillot, Naya Giannakopoulou, Sophie Barre and Wilfried Uhring
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00780H, Paper
We demonstrate Time-Correlated Single Photon Counting (TCSPC) in microfluidic droplets in high throughput conditions. We discuss the fundamental limitations in the photon acquisition rate imposed by the single photon detection...
Yang Liu, Lip Ket Chin, Wee Ser, Teck Choon Ayi, Peng Huat Yap, tarik bourouina and Yamin Leprince-Wang
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00783B, Paper
In this paper, for the first time, an on-chip optofluidic imaging system is innovated to measure the biophysical signature of single waterborne bacterium, including both the refractive index and morphology...
Cristina Potrich, Valentina Vaghi, Lorenzo Lunelli, Laura Pasquardini, Gaia Cecilia Santini, Chiara Ottone, Marzia Quaglio, Matteo Cocuzza, Fabrizio Candido Pirri, Manuela Ferracin, Massimo Negrini, Paola Tiberio, Veronica De Sanctis, Roberto Bertorelli and Cecilia Pederzolli
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00630E, Paper
There is an increasing interest in circulating microRNAs (miRNAs) as a potential minimal invasive diagnostic tool in oncology. Considerable efforts are being made in the development of Lab-On-a-Chip devices for...
João Tiago S. Fernandes, Sandra Tenreiro, Andreia Gameiro, Virginia Chu, Tiago F Outeiro and João Pedro Conde
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00756E, Paper
Parkinson’s disease (PD) is a common age-associated neurodegenerative disorder. The protein α-synuclein (aSyn) is a key actor in PD both due to its association with familial and sporadic cases, and...
Rika Wright Carlsen, Matthew R. Edwards, Jiang Zhuang, Cecile Pacoret and Metin Sitti
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00707G, Paper
We demonstrate the active control of bacteria-propelled magnetic microswimmers using remote magnetic fields.
Dario Carugo, Tobias Octon, Walid Messaoudi, Adam L. Fisher, Michele Carboni, Nick R. Harris, Martyn Hill and Peter Glynne-Jones
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00577E, Paper
Acoustically-driven continuous-flow concentration of microorganisms using a thin-reflector microfluidic resonator, with application in water quality analysis.
Bruno Pinho, Stéphane Girardon, Frédéric Bazer-Bachi, Ghislain Bergeot, Samuel Marre and Cyril Aymonier
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00505H, Paper
This paper reports a novel microfluidic-based approach for investigating the thermodynamics of multicomponent systems at high pressures and temperature, allowing for a much faster phase diagram determination compared to conventional high-pressure optical cell methods.

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