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Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 6.115 24 Issues per Year Indexed in Medline
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Brynson Lehmkuhl, Scott D. Noblitt, Amber T. Krummel and Charles S. Henry
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00759C, Paper
(a) Etching schematic of CaF2 using PDMS mold. (b) Photo of CaF2 device with NMA and D2O inlets labeled. The arrow represents where the IR spectra were taken. (c) FTIR data showing NMA and D2O mix. The arrow indicates the amide peak shift from deuteration as the position changes from the mixing area to the NMA channel.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00866B, Paper
From themed collection Lab on a Chip Recent HOT Articles
A numerical simulation setup to predict the motion of arbitrarily-shaped particles under the simultaneous effects of streaming and radiation forces.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC01016K, Paper
An electrochemical device, which consists of electrode arrays, nanocavities, and microwells, was developed for multi-electrochemical detection with high sensitivity. A local redox cycling–based electrochemical (LRC-EC) system was used for multi-electrochemical...
Soo Hyeon Kim, Maria Antfolk, Marina Kobayashi, Shohei Kaneda, Thomas Laurell and Teruo Fujii
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC01065A, Paper
We present a novel approach for high throughput single cell arraying by integrating two original microfluidic devices: an acoustofluidic chip and an electroactive microwell array.
Benjamin Gorissen, Michaël de Volder and Dominiek Reynaerts
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00775E, Paper
A novel approach to induce fluid flow using a cilia array with individually controlled pneumatic cilia, imposing metachronal waves.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00923E, Paper
Acquired drug resistance is a key factor in the failure of chemotherapy. Due to intratumoral heterogeneity, cancer cells depict variations in intracellular drug uptake and efflux at the single cell...
Heon-Ho Jeong, Venkata R. Yelleswarapu, Sagar Yadavali, David Issadore and Daeyeon Lee
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC01025J, Technical Innovation
Three dimensional monolithic elastomer device (3D MED) for kilo-scale droplet generation (1.5 L per hour) is developed using a double-sided imprinting technique.
Li Wang, Cong Xu, Yujuan Zhu, Yue Yu, Ning Sun, Xiaoqing Zhang, Ke Feng and Jianhua Qin
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00919G, Paper
We demonstrate the first attempt to differentiate human-iPSCs into cardiac microtissues on paper and create “a beating heart on paper.”
Yang Shi, Li Liang, Xiaoqiang Zhu, Xuming Zhang and Yi Yang
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC01066G, Paper
Multimode interference (MMI) is a typical self-imaging phenomenon and has been widely exploited for optical devices like couplers and splitters. Usually it utilizes solid waveguides only and thus has very...
Zheng Ao, Erika Parasido, Siddarth Rawal, Anthony Williams, Richard Schlegel, Stephen Liu, Chris Albanese, Richard J. Cote, Ashutosh Agarwal and Ram H. Datar
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC01024A, Communication
Stimulus responsive release of Circulating Tumor Cells (CTCs), with high recovery rates from their capture platform, is highly desirable for off-chip analyses.
Darrin J. Young, Peng Cong, Michael A. Suster and Margot Damaser
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00821B, Paper
This paper presents an implantable wireless battery recharging system design for bladder pressure chronic monitoring.
Manjima Dhar, Reem Khojah, Andy Tay and Dino Di Carlo
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC90101D, Highlight
Barcoded droplet-based mRNA sequencing from thousands of single cells – Exploring regulatory differences in single cells with fluidics-controlled ATAC-seq – Towards single-cell chromatin immunoprecipitation.
Saeed Rismani Yazdi, Amir Shadmani, Sebastian C. Bürgel, Patrick M. Misun, Andreas Hierlemann and Olivier Frey
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC01000D, Paper
From themed collection Lab on a Chip Recent HOT Articles
Integrated hanging-drop micropump synchronized with cardiac microtissue beating enables parallel and closed-loop medium circulation in microfluidic hanging-drop networks for multi-tissue experiments.
Yoonsun Yang, Hoon Suk Rho, Michiel Stevens, Arjan G. J. Tibbe, Han Gardeniers and Leon W. M. M. Terstappen
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00816F, Paper
We developed a microfluidic device in which single cancer cells can be placed, lysed and their DNA amplified for further interrogation.
Ayodele Fatona, Yang Chen, Michael Reid, Michael A. Brook and Jose M. Moran-Mirabal
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00741K, Paper
In this manuscript Fatona et al. describe a simple one-step in-mould method to modify PDMS surfaces with surfactants and render them permanently hydrophilic, and demonstrate its use to fabricate self-driven microfluidic devices.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00796H, Paper
We present a new approach to increase the sensitivity of magnetic bead-based microfluidic biosensor platforms with laminated low-cost soft-magnetic lattices.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00809C, Critical Review
From themed collection Lab on a Chip: Recent Review Articles
A review of microfabricated implantable devices that examines the critical role of material choice in design and fabrication.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00693G, Paper
A droplet-based microfluidics model to study deformation of double emulsions under conditions of flow cytometry hydrodynamic focusing.
Daniel J. B. Bechstein, Elaine Ng, Jung-Rok Lee, Stephanie G. Cone, Richard S. Gaster, Sebastian J. Osterfeld, Drew A. Hall, James A. Weaver, Robert J. Wilson and Shan X. Wang
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00953G, Communication
We partition magnetic sensor arrays into individually addressable microfluidic compartments, enhancing their effective use, i.e. by separating cross-reactive assays.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00801H, Paper
We developed an integrated slidable microdevice which can perform solid phase extraction, μPCR, immunochromatographic strip detection for multiplex pathogen identification on a portable genetic analyzer.
Kaixiang Zhang, Dong-Ku Kang, M. Monsur Ali, Linan Liu, Louai Labanieh, Mengrou Lu, Hamidreza Riazifar, Thi N. Nguyen, Jason A. Zell, Michelle A. Digman, Enrico Gratton, Jinghong Li and Weian Zhao
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00650C, Paper
We present a technology that can provide digital quantification of miRNA in unprocessed plasma with a LOD of 50 copies per mL.
Hoang Van Phan, M. Bulut Coşkun, Muhsincan Şeşen, Gregory Pandraud, Adrian Neild and Tuncay Alan
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00836K, Paper
A vibrating membrane with discontinuities in the form of through holes is utilised to achieve millisecond mixing.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00730E, Paper
Fluid displacement during droplet formation at microfluidic flow-focusing junctions was revealed and controlled to generate hydrogel microparticles of various morphologies.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00940E, Paper
A novel optical biosensor based on long-range surface plasmon-polariton (LRSPP) waveguides is demonstrated for the detection of leukemia markers in patient serum using a functionalization strategy based on Protein G.
W. Zhang, M. P. Tullier, K. Patel, A. Carranza, J. A. Pojman and A. D. Radadia
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00971E, Method
We demonstrate thiol–acrylate microfluidics prepared via soft lithography for single-step protein immobilization and fluorescence-based pathogen detection.

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