Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
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Michael Chu, Thao Nguyen, Eugene Kuohsi Lee, Julien Laurent Morival and Michelle Khine
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01338D, Technical Innovation
We demonstrate a facile, plasma free, process for fabricating reversibly and permanently sealed microfluidic chips using a PDMS-based adhesive polymer mixture. This method is compatible with current PDMS microfluidics processes,...
Ehsan Samiei, Maria Diaz de Leon Derby, Andre van den Berg and Mina Hoorfar
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00997B, Communication
This paper presents an electrohydrodynamic technique for rapid mixing of droplets in open and closed digital microfluidic (DMF) platforms. Mixing is performed by applying a high frequency AC voltage to...
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01208F, Paper
We developed an efficient and fast method based on a protein microarray integrated with a microfluidic chip for the process of SELEX (systematic evolution of ligands by exponential enrichment).
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01263A, Paper
An integrated device with nanoparticle assay and chaotic micromixing for rapid detection of Hendra virus antibodies.
Masumi Yamada, Wataru Seko, Takuma Yanai, Kasumi Ninomiya and Minoru Seki
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01237J, Paper
Hydrodynamic microfluidic platforms have proven useful and versatile for precisely sorting particles/cells based on their physicochemical properties. In this study, we demonstrate that a simple lattice-shaped microfluidic pattern can work...
Lynn DiMemmo, Ann Cameron Varano, Jonathan Haulenbeek, Yanping Liang, Kaya Patel, Madeline J. Dukes, Songyan Zheng, Mario Hubert, Steven P Piccoli and Deborah F. Kelly
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01160H, Paper
Understanding the properties of protein-based therapeutics is a common goal of biologists and physicians. Technical barriers in the direct observation of small proteins or therapeutic agents can limit our knowledge...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01381C, Technical Innovation
We present an image processing and analysis system to facilitate detailed performance analysis of free flow electrophoresis (FFE) chips. It consists of a cost-effective self-built imaging setup and a comprehensive...
Joshua Heinemann, Kai Deng, Jian Gao, Steve C.C. Shih, Paul d Adams, Anup K Singh and Trent R Northen
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01182A, Paper
Biological assays often require expensive reagents and tedious manipulations. These shortcomings can be overcome using digitally operated microfluidic devices that require reduced sample volumes to automate assays. One particular challenge...
Tung-Yi Lin, Truong Do, Patrick Kwon and Peter B. Lillehoj
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01430E, Technical Innovation
Plastics are one of the most commonly used materials for fabricating microfluidic devices. While various methods exist for fabricating plastic microdevices, hot embossing offers several unique advantages including high throughput,...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01362G, Technical Innovation
Membrane functionality is crucial in microfluidics for realizing operations such as filtration, separation, concentration, signaling among cells and gradient generation. Currently, common methods often sandwich commercially available membranes in multi-layer...
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01161F, Paper
An optical fiber tunneling mode is used to create 2 excitation/detection points from a single fiber.
A. M. Clark, S. E. Wheeler, C. L. Young, L. Stockdale, J. Shepard Neiman, W. Zhao, D. B. Stolz, R. Venkataramanan, D. Lauffenburger, L. Griffith and A. Wells
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01171C, Paper
Microphysiological systems fitted with hydrogel scaffolds are critical tools in the assessment and development of therapeutic strategies to target dormant metastases.
Yupan Wu, Yukun Ren, Ye Tao, Likai Hou, Qingming Hu and Hongyuan Jiang
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01346E, Paper
Induced-charge electroosmosis (ICEO) phenomena have been attracting considerable attention as a means for pumping and mixing in microfluidic systems with the advantage of simple structures and low-energy consumption. We propose...
Xin Meng, Huachuan Huang, Keding Yan, Xiaolin Tian, Wei Yu, Haoyang Cui, Yan Kong, Liang Xue, Cheng Liu and Shouyu Wang
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01321J, Paper
In order to realize high contrast imaging with portable device for potential mobile healthcare, we demonstrate a hand-held smartphone based quantitative phase microscope using transport of intensity equation method. With...
J. R. Coppeta, M. J. Mescher, B. C. Isenberg, A. J. Spencer, E. S. Kim, A. R. Lever, T. J. Mulhern, R. Prantil-Baun, J. C. Comolli and J. T. Borenstein
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01236A, Paper
A microphysiological systems platform with high precision onboard flow control supports organ model crosstalk for up to 2 weeks.
Josef J. Heiland, Rico Warias, Carsten Lotter, Laura Mauritz, Patrick J. W. Fuchs, Stefan Ohla, Kirsten Zeitler and Detlev Belder
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01217E, Communication
Seamless on-chip integration of a micro reaction unit and an HPLC functionality coupled to MS allows to study stereo selective chemical transformations at the microscale.
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01255H, Paper
We report magnetic-field-driven on-demand manipulation of liquid metal in microfluidic channels filled with base or acid.
Richard Murdock, Karen M Gallegos, Joshua Hagen, Nancy Kelley-Loughnane, Alison Weiss and Ian Papautsky
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01074A, Paper
Currently, diagnosis of influenza is performed either through tedious polymerase chain reaction (PCR) or through rapid antigen detection assays. The rapid antigen detection assays available today are highly specific but...
Chengzhi Hu, Gautam Munglani, Hannes Vogler, Tohnyui Ndinyanka Fabrice, Naveen Shamsudhin, Falk K. Wittel, Christoph Ringli, Ueli Grossniklaus, Hans J. Herrmann and Bradley J. Nelson
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01145D, Paper
A microfluidic device can trap and indent tip-growing cells for quantification of turgor pressure and cell wall Young's modulus.
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01142J, Paper
Continuous manipulation of nanoparticles using micro-vortex generated by a highly focused, high frequency surface acoustic wave (SAW) beam.
Jin-Wen Shangguan, Yu Liu, Jian-Bin Pan, Bi-Yi Xu, Jing-Juan Xu and Hong-Yuan Chen
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01250G, Paper
Microfluidic PDMS on paper devices (POP devices) make in situ analysis fast, reliable and easy to carry out.
Hugo Doméjean, Mathieu de la Motte Saint Pierre, Anette Funfak, Nicolas Atrux-Tallau, Kevin Alessandri, Pierre Nassoy, Jérôme Bibette and Nicolas Bremond
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC00848H, Paper
High-throughput production of monodisperse sub-millimeter liquid core capsules for the culture of cell aggregates or cell monolayers.
Amélie Neuville, Louis RENAUD, Thi Thuy Luu, Mona Wetrhus Minde, Espen Jettestuen, Jan Ludvig Vinningland, Aksel Hiorth and Dag Kristian Dysthe
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01253A, Paper
In this paper we propose a simple method to embed transparent reactive materials in a microfluidic cell, and to observe in situ the dissolution of the material. As an example...
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01018K, Critical Review
From themed collection Lab on a Chip: Recent Review Articles
We present a comprehensive review on the fundamentals of passive and active microfluidic droplet generation.
Thoriq Salafi, Kerwin Kwek Zeming and Yong Zhang
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01045H, Critical Review
From themed collection Lab on a Chip Recent HOT Articles
Nanoparticles have been widely implemented for healthcare and nanoscience industrial applications.

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72 citations
This review surveys the leading approaches for sorting cells in microfluidic devices and organizes those technologies by the many physical mechanisms exploited for sorting.
DOI: 10.1039/C4LC01246A
Published: 06 Jan 2015
51 citations
In this paper, a review is carried out of how 3D printing helps to improve the fabrication of microfluidic devices, the 3D printing technologies currently used for fabrication and the future of 3D printing in the field of microfluidics.
DOI: 10.1039/C5LC00685F
Published: 22 Jul 2015
55 citations
We established a microfluidic four-organ-chip for interconnected long-term co-culture of human intestine (1), liver (2), skin (3) and kidney (4) equivalents.
DOI: 10.1039/C5LC00392J
Published: 13 May 2015

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