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Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 6.115 24 Issues per Year Indexed in Medline
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Elena Afrimzon, Galina Botchkina, Naomi Zurgil, Yana Shafran, Maria Sobolev, Sergei Moshkov, Orit Ravid, Iwao Ojima and Mordechai Deutsch
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00014B, Paper
Specific phenotypic subpopulations of cancer stem cells (CSCs) are responsible for tumor development, production of heterogeneous differentiated tumor mass, metastasis, and resistance to therapies. The development of therapeutic approaches based...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC00842E, Critical Review
Implantable devices have provided various potential diagnostic options and therapeutic methods in diverse medical fields. A variety of hard-material–based implantable electrodes have been developed; however, several limitations for their chronic...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00116E, Paper
Recently, microparticles have been used as nanoporous membranes in microfluidic devices, contributing to various bioassays on a chip. Here, we report a self-assembled particle membrane (SAPM) integrated microfluidic device that...
Adnane Kara, Arnaud Reitz, Jessy Mathault, Syllia Mehou-Loko, Mehran Abbaszadeh Amirdehi, Amine Miled and Jesse Greener
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00077K, Paper
Electrochemical imaging is developed as a new chemical imaging modality for microfluidics. The technique is based on multipoint voltammetry using an embedded 20x10 microelectrode array implemented on a customized printed...
Avanish Mishra, Thora R. Maltais, THOMAS M. WALTER, Alex Wei, Stuart Joseph Williams and Steven T. Wereley
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01559F, Paper
This is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted for publication. Accepted manuscripts are published online shortly after acceptance. This version of the article will be replaced by the fully edited, formatted and proof read Advance Article as soon as this is available.
Jungkyu Kim, Amanda M. Stockton, Erik C. Jensen and Richard A. Mathies
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01397F, Critical Review
This article reviews programmable microfluidic platforms using pneumatically actuated microvalve array and their applications on biological and chemical analysis.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01544H, Paper
A minimally invasive neural probe combining microelectrodes and a droplet collection system demonstrating high temporal resolution sampling.
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01585E, Technical Innovation
We report versatile uses of multilayered polyimide (PI) film microreactors with various functions including pressure tolerance, three-dimensional mixer and multistep membrane emulsification. Such PI film microreactors were fabricated by simple...
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01481F, Paper
Micro-perfusion bioreactor on a chip for on-line detection and quantification of ECM remodeling under hydrodynamic and biochemical stimulations.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01478F, Paper
In a miniaturised flow switch fluid flows are controlled by reducing the local viscosity via absorption of laser radiation. The microfluidic chip is fabricated using Selective Laser-Induced Etching (SLE).
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01100K, Paper
We studied inertial focusing in non-rectangular channels and presented a method for particle manipulation by connection of various cross-section channels.
Fupeng Liang, An Ju, Yi Qiao, Jing Guo, Haiqing Feng, Junji Li, Na Lu, Jing Tu and Zuhong Lu
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00152A, Technical Innovation
Comparing with microfluidic devices, fabrication of structure-controllable and designable nanochannel devices has been considered to have high cost and complex procedures, which requires expensive equipments and high-quality raw materials. Exploring...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01563D, Paper
Coculturing multiple cell types together in 3-dimensional (3D) cultures better mimics the in vivo microphysiological environment, and has become widely adopted in recent years with the development of organ-on-chip systems....
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01233C, Paper
From themed collection Optofluidics
Stationary and moving liquid-core/liquid-cladding optical waveguides were established with dielectrophoresis from electrowetting-created droplets.
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01541C, Paper
We recently demonstrated direct observation of the micro-electrokinetic turbulence in a microchannel at low Reynolds number (Re), when a pressure driven flow was forced electrokinetically. Here we characterize the corresponding...
Haitao Yu, Ying Chen, Pengcheng Xu, Tiegang Xu, Yuyang Bao and Xinxin Li
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01187F, Paper
A μ-‘diving suit’ technology is developed to achieve long-time stable resonance of micro-cantilever sensors in solution for real-time bio/chemical detection.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01417D, Paper
The topography of thin films in microfluidic channels can be reconstructed at the nanometric scale from interference microscopy imaging by modelling the multiple reflections at the upper and the lower surfaces of the microchannel.
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01249J, Paper
From themed collection Optofluidics
We report a novel wash-free magnetic immunoassay technique for prostate-specific antigen (PSA) that uses a surface-enhanced Raman scattering (SERS)-based microdroplet sensor. The magnetic bar embedded in a droplet-based microfluidic system...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01365H, Paper
Lack of sensitivity is a major problem among microfluidic paper-based analytical devices (μPADs) for early disease detection and diagnosis. Accordingly, the present study presents a method for improving the enrichment...
Sarah M. Friedrich, Helena C. Zec and Tza-Huei Wang
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01294E, Critical Review
From themed collection Optofluidics
This review discusses recent advances in single molecule analysis of nucleic acid molecules within micro- and nano-fluidic environments.
Yun Chen, Zecong Fang, Brett Merritt, Dillon Strack, Jie Xu and Sungyon Lee
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01420D, Paper
We quantitatively analyze the secondary radiation force of an acoustic bubble for particle trapping and release in a flow.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01151E, Paper
A standalone microfluidic chip allows to carry out an antibiotic susceptibility test with an automatic pipette and with minimum manual labour.
Chao Liu, Chundong Xue, Jiashu Sun and Guoqing Hu
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01522G, Paper
We propose a fitting formula for the inertial lift on a sphere drawn from direct numerical simulation data obtained in straight microchannels. The formula consists of four terms that represent the shear-gradient-induced lift, the wall-induced lift, the slip-shear lift, and the correction of the shear-gradient-induced lift, respectively.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01413A, Paper
The effects of molecular confinement and crowding on enzyme kinetics were studied at length scales and under conditions similar to those found in biological cells.
Vishal Tandon, Woo Seok Kang, Tremaan A. Robbins, Abigail J. Spencer, Ernest S. Kim, Michael J. McKenna, Sharon G. Kujawa, Jason Fiering, Erin E. L. Pararas, Mark J. Mescher, William F. Sewell and Jeffrey T. Borenstein
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01396H, Paper
From themed collection Lab on a Chip Recent HOT Articles
We fabricated a micropump for reciprocating, zero-net-volume intracochlear drug delivery.

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