Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.697 24 Issues per Year Indexed in MEDLINE
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Bryan Bobo, Dana Phelan, Jonathan Rebhahn, Michael S. Piepenbrink, Bo Zheng, Tim R. Mosmann, James J. Kobie and Lisa A. DeLouise
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00580E, Paper
To address concerns with suboptimal methods for screening cells, we have developed a cell-sorting array composed of nanoliter spherical cell culture compartments termed microbubble (MB) wells. We demonstrate a proof-of-concept system for the detection of cell secreted factors from both immortalized cell lines and primary B cell samples.
YongAn Huang, YeZhou Wang, Lin Xiao, Huimin Liu, WenTao Dong and ZhouPing Yin
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00762J, Paper
This paper describes the design and characterization of microfluidic serpentine antennas with reversible stretchability and designed mechanical frequency modulation (FM). The microfluidic antennas are designed based on the Possion’s ratio...
Stefano Focaroli, Stefania Mazzitelli, Mirella Falconi, Giovanni Luca and Claudio Nastruzzi
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00679H, Paper
The present paper describes the production of microfluidic chips by an approach based on shrinkable biocompatible polymers (i.e. agarose) for the production of size controlled microfluidic channels. In addition, all...
Charles Conn, Kun Ma, George J. Hirasaki and Sibani Lisa Biswal
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00620H, Paper
Foam mobility control and novel oil displacement mechanisms were observed in a microfluidic device representing a porous media system with layered permeability. Foam was pre-generated via a flow-focusing microfluidic device...
Tríona M. O'Connell, Damien King, Chandra K. Dixit, Brendan O'Connor, Dermot Walls and Jens Ducrée
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00618F, Paper
It is now widely recognised that the earliest changes that occur on a cell when it is stressed or becoming diseased are alterations in its surface glycosylation.
A. Rival, D. Jary, C. Delattre, Y. Fouillet, G. Castellan, A. Bellemin-Comte and X. Gidrol
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00592A, Paper
A compact EWOD digital microfluidic chip enables single cell manipulation, sample preparation using magnetic beads and gene expression analysis by qRT-PCR.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00517A, Paper
Kaposi’s sarcoma (KS) is an infectious cancer occurring in immune-compromised patients, caused by Kaposi’s sarcoma herpesvirus (KSHV). Our vision is to simplify the process of KS diagnosis through the creation...
Sophia Lin, Eugene K. Lee, Nancy Nguyen and Michelle Khine
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00528G, Critical Review
This paper reviews progress in micro- and nanofabrication achieved using heat-shrinkable shape memory polymers (SMPs) and the demonstrated applications of the resulting technologies.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00502C, Paper
A portable microfluidic device for the rapid diagnosis of cancer metastatic potential is reported that is capable of separating cells according to their metastatic ability.
Shaohua Ma, Joseph M. Sherwood, Wilhelm T. S. Huck and Stavroula Balabani
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00671B, Paper
The flow topology in moving microdroplets has a significant impact on the behaviour of encapsulated objects and hence on applications of the technology.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00598H, Paper
We present a double-inkjet printing method for the generation of picoliter droplet-in-oil arrays on planar substrates, efficiently addressing droplet evaporation issues without the assistance of a humidifier or glycerol.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00686K, Paper
A plastic microdevice with an embedded filter paper disc was developed for rapid DNA extraction and “in situ” PCR amplification.
Yanbo Xie, Hans de Boer, Ad J Sprenkels, Albert van den Berg and Jan C.T. Eijkel
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00740A, Communication
In this paper, we introduce a microfluidic based self-excited energy conversion system inspired by Kelvin’s water dropper but driven by inertia instead of gravity. Two micro water jets are produced...
Giovanni Marinaro, Angelo Accardo, francesco de angelis, Thomas Dane, Britta Weinhausen, Manfred Burghammer and Christian Riekel
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00750F, Technical Innovation
We developed a new generation of superhydrophobic chips optimized for probing ultrasmall sample quantities by X-ray scattering and fluorescence techniques. The chips are based on thin Si3N4 membranes with a...
Philipp Hahn, Olivier Schwab and Jürg Dual
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00714J, Paper
We investigate how the combination of numerical simulation tools and optimization routines can be used to design micro-devices. Experimental devices that are designed in this way can only provide optimal...
Moez Haque, Kenneth KC Lee, Stephen Ho, Luis A Fernandes and Peter Herman
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00648H, Paper
The lab-on-chip (LOC) platform has presented a powerful opportunity to improve functionalization, parallelization, and miniaturization on planar or multi-level geometries that has not been possible with fiber optic technology. A...
G. Bergström, K. Nilsson, C.-F. Mandenius and N. D. Robinson
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00693C, Communication
Flowing porous gelatin microcarriers pre-seeded with cells into a microfluidic bioreactor is a simple and rapid method for creating 3D cell-culturing environments suitable for toxicity studies.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00363B, Paper
An optofluidic device named the “Insect–Human Hybrid Eye” (IHHE), which combines the architectural merits of both human camera eyes and insect compound eyes, is presented to implement imaging with a large angle of view and adaptive focusing along any direction within the field.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00700J, Paper
We present pressure tolerant 3D parallel polyimide (PI) film microreactor of up to ~160 bars with direct 3D flow focusing geometry for mass production of PEG-PLGA nanoparticles in a ~10...
Jae Hee Jung, Chao Han, Seung Ah Lee, Jinho Kim and Changhuei Yang
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00790E, Paper
The fabrication of a novel microfluidic system, integrated with a set of laser-controlled microactuators on an ePetri on-chip microscopy platform, is presented in this paper. In the fully integrated microfluidic...
Cheuk-Wing Li, Guodong Yu, Jingyun Jiang, Simon Ming-Yuen Lee, wanqing Helen Yue and Mengsu Yang
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00779D, Paper
We have developed a microfluidic device for continuous separation of small molecules from a protein mixture and demonstrated its practical use in the study of protein-ligand binding that plays a...
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00676C, Paper
From themed collection 2014 Lab on a Chip Emerging Investigators
An antibody barcode microchamber array chip permits the measurement of secreted proteins from pairs of individual tumor and macrophage cells and quantifying paracrine signaling-induced functional changes.
Hyundoo Hwang, Jan Krajniak, Yohei Matsunaga, Guy M. Benian and Hang Lu
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00697F, Communication
This paper describes a novel worm immobilization technique based on optical control of sol–gel transition of thermoreversible Pluronic gel, providing simple, versatile, and biocompatible ways for long-term high-resolution imaging and microinjection of Caenorhabditis elegans.
Florian Lapierre, Maxime Harnois, Yannick Coffinier, Rabah Boukherroub and Vincent Thomy
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00650J, Paper
How to take advantage of superhydrophobic microgrids to address the problem of coupling continuous to digital microfluidic systems? A reconfigurable capillary connection for digital microfluidic devices is presented.
Samad Ahadian, Shukuyo Yamada, Javier Ramon, Kosuke Ino, Hitoshi Shiku, Ali Khademhossein and Tomokazu Matsue
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00479E, Communication
In this manuscript we demonstrate the rapid formation of three-dimensional (3D) embryonic stem cell (ESC) aggregates with controllable sizes and shapes in hydrogels using dielectrophoresis (DEP). The ESCs encapsulated within...

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