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Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 6.115 24 Issues per Year Indexed in Medline
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Po-Hsun Huang, Chung Yu Chan, Peng Li, Nitesh Nama, Yuliang Xie, Cheng-Hsin Wei, Yuchao Chen, Daniel Ahmed and Tony Jun Huang
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00868A, Paper
An active, spatiotemporally controllable chemical gradient generator is demonstrated utilizing the acoustic streaming effects induced by acoustically oscillating sharp-edge structures.
Xiang Li, Long Luo and Richard M. Crooks
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00875A, Paper
We present a battery-powered paper-based isotachophoresis device design for focusing DNA samples having various lengths.
Vincent J. Sieben, Asok Kumar Tharanivasan, John Ratulowski and Farshid Mostowfi
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00547G, Paper
We describe a microfluidic apparatus and method for performing asphaltene yield measurements on crude oil samples.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00904A, Communication
We report a simple, efficient microfluidic array system for the reliable isolation of cells. A microfluidic array chip, integrated with a size-based cell bandpass filter, provides the unprecedented capability of...
Jonathan Shemesh, Iman Jalilian, Anthony Shi, Guan Heng Yeoh, Melissa L. Knothe Tate and Majid Ebrahimi Warkiani
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00633C, Critical Review
From themed collection Lab-on-a-Chip: Recent Review Articles
The article describes flow-induced stress on adherent cells in microfluidics devices in light of ongoing discoveries in mechanobiology.
John B. Wydallis, Rachel M. Feeny, William Wilson, Tucker Kern, Tom Chen, Stuart Tobet, Melissa M. Reynolds and Charles S. Henry
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00778J, Paper
Electrochemical imaging with high spatiotemporal resolution of dynamic norepinephrine distributions is achieved using microfluidics and a high-density CMOS platinum microelectrode array with an on-board potentiostat.
Mayte Conejero-Muriel, Isaac Rodríguez-Ruiz, Sergio Martínez-Rodríguez, Andreu Llobera and José A. Gavira
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00776C, Paper
We present a microfluidic chip, McCLEC, for crystallization, cross-linking and enzymatic reactions. We demonstrate its high stability, robustness and reusability, envisaging its promising use in biotechnological applications.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00692A, Frontier
We review a phenomenon, electrocavitation, which can be used as a platform to fundamentally study cavitation in well-defined nanofluidic systems.
Max Bogorad, Jackson DeStefano, Johann Karlsson, Andrew Wong, Sharon Gerecht and Peter Searson
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00832H, Critical Review
From themed collection Lab-on-a-Chip: Recent Review Articles
A wide range of perfusable microvessel models have been developed, exploiting advances in microfabrication, microfluidics, biomaterials, stem cell technology, and tissue endingeering. These models vary in complexity and physiological relevance,...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00798D, Paper
In this study, we realize an integrated lab-on-a-chip system with “sample-in-answer-out” multiplex gene expression analysis capabilities for point-of-care hepatotoxicity assessment.
Mark L. Porter, Joaquín Jiménez-Martínez, Ricardo Martinez, Quinn McCulloch, J. William Carey and Hari S. Viswanathan
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00704F, Paper
We developed novel fabrication methods for geo-material micromodels (e.g., shale, cement). Our unique microfluidic system represents a significant step towards assessing actual flow in real rock at reservoir conditions for subsurface energy resource applications.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00716J, Critical Review
This article provides a comprehensive overview of the physics of the gas solubility and permeability of PDMS, a systematic review of different types of vacuum-driven power-free microfluidics, design guidelines, existing applications, and the outlook.
Christoph Westerwalbesloh, Alexander Grünberger, Birgit Stute, Sophie Weber, Wolfgang Wiechert, Dietrich Kohlheyer and Eric von Lieres
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00646E, Paper
A microfluidic device for microbial single-cell cultivation of bacteria was modeled and simulated using COMSOL Multiphysics. The liquid velocity field and the mass transfer within the supply channels and cultivation...
Lidija Malic, Xuefeng F Zhang, Daniel Brassard, Liviu Clime, Jamal Daoud, Christian Luebbert, Virginie Barrere, Alex Boutin, Sabah Bidawid, Jeff Farber, Nathalie Corneau and Teodor Veres
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00852B, Paper
Infections caused by foodborne pathogens such as Listeria monocytogenes pose a threat to public health while timely detection is challenging due to pathogen low numbers. The development of robust and...
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00730E, Paper
Microdroplets and microcapsules have been widely produced using microfluidic flow-focusing junction for biomedical and chemical applications. However, the multiphase microfluidic flow at the flow-focusing junction has not been well investigated....
Hongxing Hu, David Eustace and Christoph A. Merten
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00686D, Technical Innovation
A novel approach for cell-based assays in droplets.
Jaekyung Koh, Chueh-Yu Wu, Harsha Kittur and Dino Di Carlo
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC90092A, Highlight
Injectable microporous gels formed from microfluidically-generated building blocks – Optofluidic fabrication of complex 3D particles using inertial flow sculpting – Scaling microparticle production with contact flow lithography.
Michael P. McRae, Glennon W. Simmons, Jorge Wong, Basil Shadfan, Sanjiv Gopalkrishnan, Nicolaos Christodoulides and John T. McDevitt
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00636H, Paper
From themed collection Lab on a Chip Recent HOT Articles
The programmable bio-nano-chip (p-BNC) is an ultra-flexible system for multiplexed and multiclass assays on a universal modular lab-on-a-chip platform for clinical and bioscience applications at the point-of-care.
Masumi Yamada, Ayaka Hori, Sari Sugaya, Yuya Yajima, Rie Utoh, Masayuki Yamato and Minoru Seki
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00785B, Paper
Cell-sized, highly condensed collagen microparticles were produced, which were utilized to fabricate composite multicellular spheroids of primary hepatocytes.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00588D, Critical Review
This article reviews recent developments in miniaturized neural implants for optogenetics, highlights major improvements enabled by microtechnologies, and discusses challenges faced by developers and adopters of these new technologies.
Peijun J. W. He, Ioannis Katis, Robert W Eason and Collin Lawrence Sones
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00590F, Paper
We report the use of a new laser-based direct-write technique that allows programmable and timed fluid delivery in channels within a paper substrate which enables implementation of multi-step analytical assays....
Ye Tao, Assaf Rotem, Huidan Zhang, Connie B. Chang, Anindita Basu, Abimbola O. Kolawole, Stephan A. Koehler, Yukun Ren, Jeffrey S. Lin, James M. Pipas, Andrew B. Feldman, Christiane E. Wobus and David A. Weitz
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00556F, Paper
We developed a rapid, targeted and culture-free infectivity assay using high-throughput drop-based microfluidics. The high sensitivity and large dynamic range of our cost effective assay alleviates the need for serial dilution experiments.
Wenjie Wang, Chunhua Zhou, Tingting Zhang, Jingdong Chen, Shaoding Liu and Xudong Fan
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00847F, Paper
From themed collection Lab on a Chip Recent HOT Articles
High-Q FP optofluidic laser array.
Yunpeng Zhao, Frank Schwemmer, Steffen Zehnle, Felix von Stetten, Roland Zengerle and Nils Paust
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00508F, Technical Innovation
Microparticles are widely used as solid phase for affinity based separation. Here, we introduce a new method for automated handling of microparticles in centrifugal microfluidics that is not restricted by...
Liqiang Ren, Yuchao Chen, Peng Li, Zhangming Mao, Po-Hsun Huang, Joseph Rufo, Feng Guo, Lin Wang, J. Philip McCoy, Stewart J. Levine and Tony Jun Huang
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00706B, Paper
We developed a standing surface acoustic wave (SSAW)-based cell sorting device. The throughput of our device has been significantly improved by using focused interdigital transducers (FIDTs) as SSAW generator.

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