Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.748 24 Issues per Year Indexed in MEDLINE
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Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01032A, Communication
We present a novel process to encapsulate Indocyanine Green (ICG) in liposomal droplets at high concentration for potential applications in image-guided drug delivery. The microencapsulation process follows two consecutive steps...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01290A, Paper
We demonstrate an active, implantable drug delivery device embedded with a microfluidic pump that is driven by a radio-controlled actuator for temporal drug delivery. The polyimide-packaged 10×10×2 mm3 chip contains...
Yunkyoung Choi, Heonsu Jeon and Sunghwan Kim
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01171F, Communication
Fully biocompatible laser would be of attractive use in many aspects of biomedical researches. Here we report a single-mode biocompatible distributed feedback laser consisting of silk, riboflavin and silver in...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01277A, Paper
We present a novel method for the generation of giant unilamellar vesicles and the use of fluctuation analysis to characterise their mechanical properties.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01268B, Technical Innovation
A combination of cutting edge developments is presented to characterize three-dimensional (3D) temperature and velocity fields in microscopic flows. An emulsion of non-encapsulated thermo-liquid crystal (TLC) micro spheres, with a...
Donghyuk Kim, Qingshan Wei, Janay Elise Kong, Aydogan Ozcan and Dino Di Carlo
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC90119C, Highlight
Digital measurement with a high dynamic range – Are digital nucleic acid assays more robust? – Digital measurement of membrane transporter proteins.
Alexander J. Aranyosi, Elisabeth A. Wong and Daniel Irimia
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00970C, Paper
A system that accomplishes a function analogous to a treadmill at the cellular scale helps decouple the spatial and temporal gradients during neutrophil chemotaxis.
Gonghao Wang, Kaci Crawford, Cory Turbyfield, Wilbur Lam, Alexander Alexeev and Todd Sulchek
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01150C, Paper
We report a microfluidic approach to separate and enrich a mixture of two cell types based on differences in cell viscoelastic behavior during repeated compressions and relaxation events.
Jianwei Wu, Ridong Wang, Haixia Yu, Guijun Li, Kexin Xu, Norman C. Tien, Robert C. Roberts and Dachao Li
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01121J, Paper
An additive method using inkjet-printed silver nanoparticles to fabricate a microelectrode-based biosensor inside microchannels of PDMS with MPTMS modification is proposed.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00593G, Paper
We introduce a novel technique of impedimetric sensing of cellular adhesion, which might have the potential to supplement the well-known technique of Electrical Cell-substrate Impedance Sensing (ECIS) in cell culture assays.
Magdalena A. Czekalska, Tomasz S. Kaminski, Slawomir Jakiela, K. Tanuj Sapra, Hagan Bayley and Piotr Garstecki
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00985A, Paper
We report a droplet microfluidic system that automates the formation of lipid bilayers and allows for electrophysiological measurements and for an automated screening protocols in which the activity of proteins is tested against inhibitors.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01013B, Paper
Easy movement of oxidized Galinstan in microfluidic channels is a promising way for the wide application of the non-toxic liquid metal. In this paper, two different surface modification techniques (physical...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01094A, Paper
In this work, we present a novel fabrication process that enables the monolithic integration of lateral porous silicon membranes into single-layer planar microchannels. This fabrication technique relies on the patterning...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00944D, Focus
The purpose of this paper is to present a new approach for introducing to a non-scientific audience a major public health issue: access to safe drinking water. Access to safe...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01046A, Paper
We present a novel microfluidic platform to visualize the formation of free-standing films by interfacial polymerization. A microfluidic device is fabricated, with an array of micropillars to stabilize an aqueous-organic...
Xudong Lin, Shiqi Wang, Xudong Yu, Zhuguo Liu, Fei Wang, Wai Tsun Li, Shuk Han Cheng, Qiuyun Dai and Peng Shi
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01186D, Paper
A microfluidic system, Fish-Trap, was developed to enable automatic, gel-free, and anesthetic-free immobilization and orientation of zebrafish larvae, allowing high-throughput mapping of drug-induced brain-wide neural activity in awake vertebrates with single-cell resolution.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01028K, Paper
We report the development of a microfluidic assay and a real-time, automatic progeny counting system that records progeny counting information from many individual C. elegans hermaphrodites.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00949E, Paper
We present a thorough experimental and theoretical analysis of nanoscale electrokinetics using ion-selective nanochannel networks formed by geometrically controlled in situ self-assembled nanoparticles.
Karla Perez-Toralla, Guillaume Mottet, Ezgi TULUKCUOGLU GUNERI, Jerome Champ, François-Clément Bidard, Jean-Yves Pierga, Jerzy Klijanienko, Irena Draskovic, Laurent Malaquin, Jean-Louis Viovy and Stephanie Descroix
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01059K, Paper
Microfluidic systems bears promise to provide new powerful tools for the molecular characterization of cancer cells, in particular for the routine detection of multiple cancer biomarkers using a minute amount...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00943F, Paper
Payloads including FITC-Dextran dye and plasmids were delivered into NIH/3T3 fibroblasts using microbubbles produced by micro-second laser pulses to induce pores in the cell membranes. Two different operational modes were...
Jonathan Wehking and Ranganathan Kumar
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00934G, Paper
This work demonstrates that liquid droplet emulsions in a microchannel can be deformed, decelerated and/or pinned by applying a suitable electrical potential. By concentrating a potential gradient at the corners,...
Abraham K. Badu-Tawiah, Shefali Lathwal, Kaja Kaastrup, Mohammad H. Al-Sayah, Dionysios C. Christodouleas, Barbara S. Smith, George M Whitesides and Hadley D. Sikes
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01239A, Technical Innovation
Diagnostic tests in resource-limited settings require technologies that are affordable and easy to use with minimal infrastructure. Colorimetric detection methods that produce results that are readable by eye, without reliance...
Mathieu Odijk, Andries Dirk van der Meer, Daniel Levner, Hyun Jung Kim, Marinke W van der Helm, Loes Segerink, Jean-Phillipe M.S. Frimat, Geraldine Hamilton, Donald Ingber and Albert van den Berg
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01219D, Paper
Trans-epithelial electrical resistance (TEER) measurements are widely used as real-time, non-destructive, and label-free measurements of epithelial and endothelial barrier function. TEER measurements are ideal for characterizing tissue barrier function in...
Tushar D. Rane, Liben Chen, Helena Claire Zec and Jeff Tza-Huei Wang
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01158A, Paper
Digital nucleic acid detection is rapidly becoming a popular technique for ultra-sensitive and quantitative detection of nucleic acid molecules in a wide range of biomedical studies. Digital polymerase chain reaction...
Michael Erickstad, Laura Hale, Sreekanth Chalasani and Alex Groisman
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00717D, Paper
Oxygen is essential for metabolism of vertebrate animals and is a vital component of their natural habitats. Hypoxic conditions in tissue, when oxygen levels are lower than normal, change a...

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