Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.748 24 Issues per Year Indexed in MEDLINE
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Minsoung Rhee, Yooli K Light, Suzan Yilmaz, Paul d Adams, Deepak Saxena, Robert J Meagher and Anup K Singh
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00823E, Paper
Picoinjection is a promising technique to add reagents into pre-formed emulsion droplets on chip; however, it is sensitive to pressure fluctuation, making stable operation of the picoinjector challenging. We present...
Hardik J. Pandya, Wenjin Chen, Lauri A. Goodell, David J. Foran and Jaydev P. Desai
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00594E, Paper
The mechanical properties of tissue change significantly during the progression from healthy to malignant.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01014K, Paper
This paper discusses a novel, simple, and inexpensive micro-volume ultrafiltration technique for protein concentration, desalting, buffer exchange, and size-based protein purification. The technique is suitable for processing protein samples in...
Collin Lawrence Sones, Ioannis Katis, Peijun J. W. He, Ben Mills, Medya Fouad Namiq, Peter Shardlow, Morten Ibsen and Robert W Eason
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00850B, Paper
Paper-based microfluidics is a rapidly progressing inter-disciplinary technology driven by the need for low-cost alternatives to conventional point-of-care diagnostic tools. For transport of reagents/analytes, such devices often consist of interconnected...
E. Ortiz-Ortega, Marc-Antoni Goulet, Jin Wook Lee, M Guerra-Balcázar, Noé Arjona, Erik Kjeang, J. Ledesma-García and L. G. Arriaga
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01010H, Communication
The use of three-dimensional flow-through nanoporous electrodes was explored and successfully applied in a formic acid air-breathing nanofluidic fuel cell. The effects of fuel concentration, reaction stoichiometry and catalyst mass...
Ghulam Destgeer, Byung Hang Ha, Jin Ho Jung and Hyung Jin Sung
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00868E, Paper
Submicron separation is the segregation of the particles having diameter difference of less than one micrometre. We present an acoustofluidic particle separator with submicron separation resolution to study the continuous,...
JiSoo Park, Bo Kyeong Lee, Gi Seok Jeong, Jung Keun Hyun, Changjoon Justin Lee and Sang-Hoon Lee
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00962B, Paper
There has been a growing need for in vitro models of neurodegenerative diseases such as Alzheimer’s disease that would enable a better understanding of etiology and faster development of treatment...
Raffaella Molteni, Elena Bianchi, Paolo Patete, Monica Fabbri, Guido Baroni, Gabriele Dubini and Ruggero Pardi
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00741G, Paper
Leukocyte extravasation and interstitial migration are key events during inflammation. Traditional in vitro techniques address only specific steps of cell recruitment to tissues and fail to recapitulate the whole process...
Gui-Ping Zhu, Majid Hejazian, Xiaoyang Huang and Nam-Trung Nguyen
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00885E, Paper
Magnetic manipulation is a promising technique for lab-on-a-chip platforms. The magnetic approach can avoid problems associated with heat, surface charge, ionic concentration and pH level. The present paper investigates the...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00869C, Paper
In recent years there has been great progress harnessing the small-feature size and programmability of integrated circuits (ICs) for biological applications, by building microfluidics directly on top of ICs. However,...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00990H, Paper
The molecular stretching of DNA is an indispensable tool for the optical exploration of base sequences and epigenomic changes of DNA at a single molecule level. In stretching terminal-unmodified DNA...
Hyewon Lee, Shin Ae Kim, Sean Coakley, Paula Mugno, Marc Hammarlund, Massimo A. Hilliard and Hang Lu
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00789A, Paper
We present a high-density microfluidic device for target-selective illumination, selective stimulation, and long-term monitoring of C. elegans.
Alvaro J. Conde, Milena Batalla, Belén Cerda, Olga Mykhaylyk, Christian Plank, Osvaldo Podhajcer, Juan M. Cabaleiro, Rossana E. Madrid and Lucia Policastro
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00839A, Paper
A low-cost, portable microfluidic platform for preparing monodisperse magnetoliposomal suspensions that does not require extrusion steps.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00734D, Paper
We present a novel paper-based analytical device for isotachophoretic sample focusing, enabling processing of a 30 μL sample and a 1000-fold increase in peak concentration in several minutes.
Nicolas C. Pégard, Marton L. Toth, Monica Driscoll and Jason W. Fleischer
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00701H, Communication
From themed collection Lab on a Chip 2014 HOT Articles
We present a 3D tomography technique for in vivo observation of microscopic samples.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00785A, Paper
This paper describes the development of a new, easy-to-implement approach to generate high-throughput microfluidic particle-separation devices.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00895B, Technical Innovation
We applied a simple evaporation-based self-assembly technique to create a sub-50 nm nanofluidic junction between two microchannels in PDMS.
Yuliang Zhao, Hok Sum Sam Lai, Guanglie Zhang, Gwo-Bin Lee and Wen Jung Li
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00795F, Paper
Single-cell density and mass were measured rapidly using a combination of optically induced electrokinetics, microfluidics, computer vision, and classical sedimentation theory.
Zhuoqing Yang, Yi Zhang, Toshihiro Itoh and Ryutaro Maeda
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00997E, Technical Innovation
We present a novel lab-on-a-tube technology, which is a combination of three-dimensional (3D) cylindrical photolithography and nanoimprint process, for fabricating micro functional structures on tiny tube substrate directly. As example,...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00928B, Paper
Supported lipid bilayers (SLBs) have been used for various biosensing applications. The bilayer structure enables embedded lipid membrane species to maintain their native orientation, and the two-dimensional fluidity is crucial...
Siwei Li, Peter Glynne-Jones, Orestis Andriotis, Kuan Yong Ching, Umesh Sai Jonnalagadda, Richard Oreffo, Martyn Hill and Rahul Shrikant Tare
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00956H, Paper
Cartilage grafts generated using conventional static tissue engineering strategies are characterised by low cell viability, suboptimal hyaline cartilage formation and, critically, inferior mechanical competency, which limit their application for resurfacing...
Martin D. Brennan, Megan L. Rexius-Hall, Laura Jane Elgass and David T. Eddington
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00853G, Critical Review
Cellular function and behavior are affected by the partial pressure of O2, or oxygen tension, in the microenvironment.
Delphine Le Roux, Brian E. Root, Jeffrey A. Hickey, Orion N. Scott, Anchi Tsuei, Jingyi Li, David J. Saul, Luc Chassagne, James P. Landers and Philippe de Mazancourt
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00685B, Paper
A fully integrated microfluidic chip for STR human identification analysis has been developed that includes a DNA enzymatic liquid preparation, microliter non-contact PCR, and a polymer allowing high-resolution separation.
PinTso Lin, HengYi Chu, TsanWen Lu and PoTsung Lee
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00731J, Paper
We propose and demonstrate a trapping configuration integrating coupling waveguide and gold bowtie structure to form a near-field plasmonic tweezers. Compared with excitation from the top, wave coupled through the...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00798K, Paper
The breakup dynamics in non-Newtonian multiphase microsystems are associated with a variety of industrial applications such as food production and biomedical engineering. In this study, we numerically and experimentally characterize...

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