Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.697 24 Issues per Year Indexed in MEDLINE
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Hongbo Zhou, Gang Li and Shuhuai Yao
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51442K, Paper
A stable microenvironment with pH ranging from 3 to 11 is achieved by on-demand control of droplet formation and electrolysis.
Petra Paiè, Francesca Bragheri, Rebeca Martinez Vazquez and Roberto Osellame
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00133H, Paper
A femtosecond laser fabricated microfluidic module for 3D hydrodynamic focusing allows confinement of fluids to a tight area in the channel center.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00023D, Paper
Fascicle-inspired tissue strips were generated having high (~100 s) length to diameter ratios using a novel external sacrificial molding method. High levels of alignment, 3D cell distribution, and cell density are demonstrated.
Anushi Rajapaksa, Aisha Qi, Leslie Y. Yeo, Ross Coppel and James R. Friend
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00232F, Paper
A practical, commercially viable microfluidic device relies upon the miniaturization and integration of all its components—including pumps, circuitry, and power supply—onto a chip-based platform.
Matthew P Horning, Charles Delahunt, S Ryan Singh, Spencer H Garing and Kevin P Nichols
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00293H, Paper
A paper microfluidic cartridge for the automated staining of malaria parasites (Plasmodium) with acridine orange prior to microscopy is presented. The cartridge enables simultaneous, sub-minute generation of both thin and...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00197D, Paper
We report the design, the fabrication and evaluation of an array of microdevices composed of high aspect ratio PDMS pillars, dedicated to the study of tumour spheroid mechanical properties. The...
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00015C, Paper
Chitosan/cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG ODN) nanoparticles as potential immunostimulatory adjuvants were synthesized by the conventional bulk mixing (BM) method and a novel microfluidic (MF) method.
Wei Liu, Yaqian Li, Siyu Feng, Jia Ning, Jingyu Wang, Maling Gou, Huijun Chen, Feng Xu and Yanan Du
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00081A, Paper
Microtissues on the scale of several hundred microns are a promising cell culture configuration resembling the functional tissue units in vivo.
Il Hyung Shin, Ki-jung Kim, Jiman Kim, Hee Chan Kim and Honggu Chun
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00024B, Technical Innovation
A cation-selective microfluidic sample preconcentration system is described using anion-permselective TMSVE- or polyE-323-coated nanochannels or a positively charged nanoporous polymer (PDADMAC) placed between positively-surface-coated microchannels.
Tim Femmer, Alexander Kuehne and Matthias Wessling
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00320A, Technical Innovation
Polydimethylsiloxane is a translucent and biologically inert silicone material used in sealants, biomedical implants and microscale lab-on-a-chip devices. Furthermore, in membrane technology polydimethylsiloxane represents a material for separation barriers as...
Christian Rensch, Simon Lindner, Ruben Salvamoser, Stephanie Leidner, Christoph Böld, Victor Samper, David Taylor, Marko Baller, Stefan Riese, Carmen Wängler and Björn Wängler
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00076E, Paper
The application of microfluidics to the synthesis of Positron Emission Tomography (PET) tracers has been explored for more than a decade. Microfluidic benefits such as superior temperature control have been...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00162A, Paper
A deep understanding of the mechanisms behind neurite polarization and axon path-finding is important for interpreting how the human body guides neurite growth during development and response to injury. Further,...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00192C, Paper
The deposition of asphaltenes in porous media, an important problem in science and macromolecular engineering, was for the first time investigated in a transparent packed-bed microreactor (μPBR) with online analytics...
Jayda L. Erkal, Asmira Selimovic, Bethany C. Gross, Sarah Y Lockwood, Eric Walton, Stephen McNamara, R. Scott Martin and Dana Spence
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00171K, Paper
We report two, 3D printed devices that can be used for electrochemical detection. In both cases, the electrode is housed in commercially available, polymer-based fittings so that the various electrode...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00150H, Paper
DNA methylation is an epigenetic modification essential for normal development and maintenance of somatic biological functions. DNA methylation provides heritable, long-term chromatin regulation and aberrant methylation pattern is associated with...
Zhifeng Lin, Yuhong Ma, Changwen Zhao, Ruichao Chen, Xing Zhu, Lihua Zhang, Xu Yan and Wantai Yang
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00223G, Paper
Protein microarrays have become vital tools for various applications in biomedicine and bio-analysis during the past decade. The intense requirements for a lower detection limit and industrialization in this area...
Vittorio Bianco, Francesco Merola, Lisa Miccio, Pasquale Memmolo, Oriella Gennari, Melania Paturzo, Paolo Antonio Netti and Pietro Ferraro
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00290C, Paper
Imaging through turbid media is a challenging topic. A liquid is considered turbid when dispersed particles provoke strong light scattering, thus destroying the image formation by any standard optical system....
Carson T. Riche, Chuchu Zhang, Malancha Gupta and Noah Malmstadt
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00087K, Paper
Vapor deposited fluoropolymer coatings enabled extraction-induced merging of droplets and high frequency generation of droplets within PDMS microfluidic devices.
Nahid Babaei Aznaveh, Muhammad Safdar, Gideon Wolfaardt and Jesse Greener
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00084F, Paper
We present a flow-templating micro-bioreactor as a new concept for controlled patterning of linear biofilm formations. Experiments and simulations comprehensively exploit control parameters to grow biofilm patterns with controllable dimensions. The paper concludes with a study of biofilm growth rates under well-defined shear stress environments.
Hyoungseon Choi, Chang Su Jeon, Inseong Hwang, Juhui Ko, Saram Lee, Jaebum Choo, Jin-Hyo Boo, Hee Chan Kim and Taek Dong Chung
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00238E, Paper
Detection of pathogenic bacteria requires a sensitive, accurate, rapid, and portable device. Given that lethal microbes are of various sizes, bacterial sensors based on DC (direct current) impedance on chips...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00036F, Paper
In this work, we present a methodological approach to analyze an enhanced dielectrophoresis (DEP) system from both a circuit analysis and an electrothermal view points. In our developed model, we...
Meltem Elitas, Rodrigo Martinez-Duarte, Neeraj Dhar, John McKinney and Philippe Renaud
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00109E, Paper
Persistence of bacteria during antibiotic therapy is a widespread phenomenon, of particular importance in refractory mycobacterial infections such as leprosy and tuberculosis. Persistence is characterized by the phenotypic tolerance of...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00172A, Frontier
These insights attempt to share with the community the lights and shadows of one emerging and exciting topic, Food Microfluidics, defined as the Microfluidic technology for food analysis and diagnosis...
Shailender Singh Kanwar, Christopher James Dunlay, Diane M. Simeone and Sunitha Nagrath
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00136B, Paper
Microfluidic all-in-one device “ExoChip” for isolation, quantification and analysis of circulatory exosomes: bridging the gap between technology and clinical application.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00079J, Paper
As outstanding catalyst supports, chitosan–silica core–shell hybrid microspheres have been prepared using a facile microfluidic approach.

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