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Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.586 24 Issues per Year Indexed in Medline
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Junchao Wang, Philip Brisk and William H. Grover
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00758A, Paper
In this work we created functional microfluidic chips without actually designing them. We accomplished this by first generating a library of thousands of different random microfluidic chip designs, then simulating...
Jason C Harper, Jenna M. Andrews, Candice Ben, Andrew C. Hunt, Jaclyn K. Murton, Bryan D Carson, George Bachand, Julie A. Lovchik, William D. Arndt, Melissa R. Finley and Thayne L. Edwards
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00858E, Paper
Since the introduction of micro total analytical systems (μTASs), significant advances have been made toward development of lab-on-a-chip platforms capable of performing complex biological assays that can revolutionize public health,...
Yaoping Liu, LINGQIAN ZHANG, CHI MO, Yan-Ping Cao, Wengang Wu and Wei Wang
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01086E, Paper
Surface functionalization of polydimethylsiloxane (PDMS) is important in developing high-performanced microfluidic devices. This work applied the thermal chemical vapor deposition (t-CVD) of Parylene-C onto PDMS to caulk the molecular network...
Wenming Liu, Chang Tian, Mingming Yan, Lei Zhao, Chao Ma, Tianbao Li, Juan Xu and Jinyi Wang
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00996D, Paper
We present a microfluidic platform reusable for culturing various heterotypic and homotypic 3D tumors with spatiotemporal and high-throughput control.
Lingqian Chang, Lei Li, Junfeng Shi, Yan Sheng, Wu Lu, Daniel Gallego-Perez and Ly James Lee
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00840B, Tutorial Review
In this review, the technical aspects of micro- and nanoscale electroporation with their representative cutting-edge research, including gene editing (CRISPR-Cas9), adoptive immunotherapy, and cellular reprogramming. The challenges and opportunities of advanced electroporation technologies are discussed.
Ankit Kumar, Shigeng Li, Chieh-Min Cheng and Daeyeon Lee
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC01060A, Paper
Flow-induced phase inversion of O/W emulsions into W/O emulsions in hydrophobic tapered phase inversion channels (PICs).
Joo Chuan Yeo, Kenry and Chwee Teck Lim
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00926C, Frontier
There has been an emerging interest in the development of microfluidic wearable technologies, arising from increasing demands in the areas of healthcare.
Rahim Rahimi, Su Su Htwe, Manuel Ochoa, Amy Donaldson, Michael Zieger, Rajiv Sood, Ali Tamayol, Ali Khademhosseini, Amir Ghaemmaghami and Babak Ziaie
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00866F, Communication
Culturing cells at air-liquid interface (ALI) is essential for creating functional in-vitro models of lung tissue. We present the use of direct-patterned laser-treated hydrophobic paper as an effective semi-permeable membrane,...
Liang Zhu, Huanming Xia, Zhenfeng Wang, Eliza Li Shan Fong, Junjun Fan, Wen Hao Tong, Yen Peng Daphne Seah, Weian Zhang, Qiushi Li and Hanry Yu
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00811A, Technical Innovation
Compaction by vertical flow perfusion induces an in vivo-like cuboidal morphology of hepatocytes in monolayer culture, which enhances polarity and hepatic functions in long-term in vitro culture for drug testing applications.
Yankai Jia, Yukun Ren, Weiyu Liu, Likai Hou, Ye Tao, Qingming Hu and Hongyuan Jiang
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01052K, Communication
We utilize ac electric field to trigger the on-demand fusion of two aqueous cores inside Water-in-Oil-in-Water (W/O/W) double-emulsion drops. We attribute the coalescence phenomenon to field-induced structural polarization and breakdown...
Nan-Nan Deng, Wei Wang, Xiao-Jie Ju, Rui Xie and Liang-Yin Chu
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01022A, Paper
Precise manipulation of droplets in microfluidics has revolutionized a myriad of drop-based technologies, such as multiple emulsion preparation, drop fusion, drop fission, drop trapping and drop sorting, which offer promising...
Viviane Lutz-Bueno, Jianguo Zhao, Raffaele Mezzenga, Thomas Pfohl, Peter Fischer and Marianne Liebi
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00690F, Paper
Microfluidics applies designed and well-controlled flow fields, while scanning-SAXS determines the local fluid structure. When combined, the relation between structural transitions and flow fields can be explored.
Jun Zhang, Sheng Yan, Dan Yuan, Qianbin Zhao, Say Hwa Tan, Nam-Trung Nguyen and Weihua Li
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC01007E, Paper
We proposed and developed a novel viscoelastic ferrofluid, and demonstrated its superior advantages for continuous sheathless separation of nonmagnetic particles.
Mahiar M. Hamedi, Barış Ünal, Emily Kerr, Ana C. Glavan, M. Teresa Fernandez-Abedul and George M. Whitesides
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00975A, Communication
This communication describes the use of uncoated cellophane (regenerated cellulose films) for the fabrication of microplates, and the use of coated cellophane for the fabrication of open-channel microfluidic devices.
Yu Shrike Zhang, Farideh Davoudi, Philipp Walch, Amir Manbachi, Xuan Luo, Valeria Dell'Erba, Amir K. Miri, Hassan Albadawi, Andrea Arneri, Xiaoyun Li, Xiaoying Wang, Mehmet Remzi Dokmeci, Ali Khademhosseini and Rahmi Oklu
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00380J, Paper
From themed collection 3D Printing
A novel bioprinted model of thrombosis was developed to study thrombosis and thrombolysis in vitro.
Alborz Feizi, Yibo Zhang, Alon Greenbaum, Alex Guziak, Michelle Luong, Raymond Yan Lok Chan, Brandon Berg, Haydar Ozkan, Wei Luo, Michael Wu, Yichen Wu and Aydogan Ozcan
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00976J, Paper
Monitoring yeast cell viability and concentration is important in brewing, baking and biofuel production. However, existing methods of measuring viability and concentration are relatively bulky, tedious and expensive. Here we...
Marie-Charlotte Horny, Mathieu Lazerges, Jean-Michel Siaugue, Antoine Pallandre, Daniel Rose, Fethi Bedioui, Claude Deslouis, Anne-Marie Haghiri-Gosnet and Jean Gamby
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00869K, Paper
Here we transposed an ultramicroelectrode (UME) setup into a microfluidic chip configuration for DNA biosensors. Hydrodynamics properties of the fluidic channel microelectrode were screened with [Fe(III)(CN)6]3-/[Fe(II)(CN)6]4- redox couple in cyclic...
Esther Amstad, Michael Chemama, Maximilian Eggersdorfer, Laura Rodriguez Arriaga, Michael Brenner and David A. Weitz
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01075J, Paper
Monodisperse drops with diameters between 20 μm and 200 μm can be used to produce particles or capsules for many applications such as for cosmetics, food, and biotechnology. Drops composed...
Gabriel Amselem, Cyprien Guermonprez, Benoit Drogue, Sébastien Michelin and Charles N Baroud
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00968A, Paper
In spite of the large number of droplet-based microfluidic tools that have appeared in recent years, their penetration into non-specialist labs remains limited to a small number of applications. This...
Javier Lopez Prieto, Hao-Wei Su, Han Wei Hou, Miguel Pinilla Vera, Bruce D Levy, Rebecca M Baron, Jongyoon Han and Joel Voldman
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00940A, Paper
Sepsis is a potentially lethal condition that might benefit from early monitoring of circulating activated leukocytes for faster stratification of severity of illness and improved administration of targeted treatment. Characterization...
Mahtab Hassanpourfard, Ranajay Ghosh, Thomas Thundat and Aloke Kumar
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC01055E, Communication
Bacterial streamer induced clogging regime is characterized by stick-slip fronts and instabilities resulting in formation of water channels.
Liang Hu, Anle Ge, Xixian Wang, Shanshan Wang, Yue Gao, Xiaojun Feng, Wei Du and Bi-Feng Liu
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00948D, Paper
We report an on-demand gas segmented flow generator with high spatiotemporal resolution to analyze neuronal responses of C. elegans to fluctuating gas cues.
Gangadhar Eluru, Albina Lourdes Nirupa Julius and Sai Siva Gorthi
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00935B, Paper
The recent, rapid growth of microfluidic applications has witnessed the emergence of several particle flow focusing techniques for analysis and/or further processing. Majority of flow focusing techniques employ external sheath...
J. Y. Han, O. D. Rahmanian, E. L. Kendall, N. Fleming and D. L. DeVoe
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00862C, Paper
Screw-based micropumps enable precise software-defined flow control with integrated on-chip reagents for portable assays.
L. Zhang, Q. Cai, R. S. Wiederkehr, M. Fauvart, P. Fiorini, B. Majeed, M. Tsukuda, T. Matsuno and T. Stakenborg
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC01046F, Paper
We present a silicon-based integrated microsystem combining a blood lysis chamber, a cross-flow filter, a T-junction mixer, and a microreactor for quantitative polymerase chain reaction. The detection of multiple single nucleotide polymorphisms was demonstrated in the system from human blood.

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42 citations
In this paper, a review is carried out of how 3D printing helps to improve the fabrication of microfluidic devices, the 3D printing technologies currently used for fabrication and the future of 3D printing in the field of microfluidics.
DOI: 10.1039/C5LC00685F
Published: 22 Jul 2015
58 citations
This review surveys the leading approaches for sorting cells in microfluidic devices and organizes those technologies by the many physical mechanisms exploited for sorting.
DOI: 10.1039/C4LC01246A
Published: 06 Jan 2015
46 citations
We established a microfluidic four-organ-chip for interconnected long-term co-culture of human intestine (1), liver (2), skin (3) and kidney (4) equivalents.
DOI: 10.1039/C5LC00392J
Published: 13 May 2015

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