Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.748 24 Issues per Year Indexed in MEDLINE
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Valentina Arima, Ilenia Viola, alessandra zizzari, Monica Bianco, Ruggero Miglietta, Loretta Del mercato, Mauro Carraro, Antonio Sorarù, Marcella Bonchio, Giuseppe Gigli and Ross Rinaldi
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00791C, Paper
Liquid flow in microchannels is completely laminar and uniaxial, with very low Reynolds number (Re) regime and long mixing lengths. To increase fluid mixing and reactants solubility, as well as...
Delphine Le Roux, Brian E. Root, Jeffrey Hickey, Orion N. Scott, Anchi Tsuei, Jingyi Li, David J. Saul, Luc Chassagne, James Landers and Philippe de Mazancourt
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00685B, Paper
A fully-integrated microfluidic chip for human identification by short tandem repeat (STR) analysis has been developed that includes a unique enzymatic liquid preparation of the DNA, microliter non-contact PCR, and...
Qiang Zhang, Peiran Zhang, Yetian Su, Chunbo Mou, Menglong Yang, Jian Xu and Bo Ma
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00833B, Technical Innovation
A simple, low-cost and on-demand microfluidic controlling platform was developed based on a unique capillary-tuned solenoid microvalve suction effect without any outer pressure source. The suction effect was innovatively employed...
Jérémie Léonard, Norbert Dumas, Jean-Pascal Caussé, Sacha Maillot, Naya Giannakopoulou, Sophie Barre and Wilfried Uhring
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00780H, Paper
Time-correlated single photon counting (TCSPC) was demonstrated in microfluidic droplets for high-throughput, time-resolved fluorescence (bio)sensing of nanosecond-lived fluorophores.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00645C, Communication
By combining the gravity and magnetic force, we developed a versatile and facile microfluidic method to form magnetic decentered core-shell microcapsules in which the directions of the core and the...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00879K, Paper
This is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted for publication. Accepted manuscripts are published online shortly after acceptance. This version of the article will be replaced by the fully edited, formatted and proof read Advance Article as soon as this is available.
Aurélien André Paul Trichet, James Foster, Naomi Elyse Omori, Dean James, Philip Ronald Dolan, Gareth Hughes, Claire Vallance and Jason Smith
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00817K, Paper
Open-access optical microcavities provide a novel approach to label-free lab-on-a-chip optofluidic sensing. They offer direct access to a highly confined electromagnetic field, and yield a femtoliter detection volume. This article...
Haig Norian, Ryan M. Field, Ioannis Kymissis and Kenneth L. Shepard
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00443D, Paper
qPCR demonstrated on the surface of a CMOS integrated circuit using embedded heaters, temperature sensors, photodiodes, and electrowetting-based droplet transport mechanism.
Cristina Potrich, Valentina Vaghi, Lorenzo Lunelli, Laura Pasquardini, Gaia Cecilia Santini, Chiara Ottone, Marzia Quaglio, Matteo Cocuzza, Candido Fabrizio Pirri, Manuela Ferracin, Massimo Negrini, Paola Tiberio, Veronica De Sanctis, Roberto Bertorelli and Cecilia Pederzolli
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00630E, Paper
Circulating oncomiRs are purified and directly reverse transcribed in the same functionalized PDMS parallel chip.
Charles A Cartier, Aaron M Drews and Kyle Bishop
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00811A, Paper
We present a simple and effective ratcheted microfluidic mixer that uses contact charge electrophoresis (CCEP) of a micron-scale particle to rapidly mix nonpolar liquids. CCEP combines contact charging and electrostatic...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00828F, Tutorial Review
Microfluidic or microchannel artificial lungs promise to enable a new class of truly portable, therapeutic artificial lungs through feature sizes and blood channel designs that closely mimic those found in...
Ruben Soares, Pedro Novo, Ana Azevedo, Pedro Fernandes, Maria Raquel Aires-Barros, Virginia Chu and João Pedro Conde
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00695J, Paper
Immunoassays are fast and sensitive techniques for analyte quantification and their use in point-of-care devices for medical, environmental, and food safety applications have potential benefits of cost, portability, and multiplexing....
Kelvin M. Frazier, Katherine A. Mirica, Joseph J. Walish and Timothy M. Swager
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00864B, Paper
Mechanical abrasion is an extremely simple, rapid, and low-cost method for deposition of carbon-based materials onto a substrate.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00801D, Technical Innovation
Insulator-based dielectrophoresis enables contact-less separation and analysis of biosystems, but it is unable to operate effectively in the MHz frequency range, which is necessary for the manipulation of biological cells...
Ahmed Alfadhel, Bodong Li, Amir Omar Zaher, Omar Yassine and Jurgen Kosel
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00821A, Paper
A magnetic nanocomposite has been implemented as artificial hair on a giant magneto-impedance (GMI) thin film sensor for flow sensing. The 500 μm long and 100 μm in diameter pillars...
Lukas C Gerber, Liat Rosenfeld, Yunhan Chen and Sindy K Y Tang
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00640B, Communication
We describe the use of chemical diffusion and reaction to record temporally-varying chemical information as spatial patterns without the need for external power. Diffusion of chemicals acts as a clock,...
João Tiago S. Fernandes, Sandra Tenreiro, Andreia Gameiro, Virginia Chu, Tiago F. Outeiro and João P. Conde
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00756E, Paper
We report a novel platform combining a gradient generator with single-cell traps to study the expression of alpha-synuclein under different stimuli in a yeast model to investigate the mechanisms behind Parkinson's disease.
Gungun Lin, Denys Makarov, Michael Melzer, Wenping Si, Chenglin Yan and Oliver G. Schmidt
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00751D, Paper
A highly flexible GMR-based microfluidic analytic device was demonstrated to analyze droplets of various dimensions and different concentrations of magnetic contents.
Bin-Da Chan, Kutay Icoz, Wanfeng Huang, Chun-Li Chang and Cagri A. Savran
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00765D, Paper
A method to weigh individually selected biological microparticles over a dynamic range of 30 pg to 2.4 μg. The figure shows a single pollen grain specifically picked and placed on the left-hand cantilever for weighing; on the right-hand cantilever is a bead used as a reference.
Roman Gerbers, Wilke Foellscher, Hong Chen, Constantine Anagnostopoulos and Mohammad Faghri
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00786G, Paper
A paper-based immunosensor incorporating a microfluidic valve technology which autonomously manipulates multiple fluids to sequentially flow over a detection area.
Baichen Li, Lin Li, Allan Guan, Quan Dong, Kangcheng Ruan, Ronggui Hu and Zhenyu Li
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00227J, Paper
Microfluidics and lab-on-a-chip technologies have made it possible to manipulate small volume liquids with unprecedented resolution, automation and integration. However, most current microfluidic systems still rely on bulky off-chip infrastructures...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00560K, Paper
Pressure-tolerant polymer-glass microfluidic reactors with excellent bonding strength have been fabricated by simultaneous solidification-bonding (SSB) method, in which a viscous and reactive matrix polymer was cast on the glass substrate...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00804A, Paper
Abnormal DNA methylation has been associated with the development and progression of several human cancers and is a potential target for treatment. Thus, myriad technologies for the analysis of DNA...
Yan Pang, Hyoungsoo Kim, Zhaomiao Liu and Howard A. Stone
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00871E, Paper
We study the effect of softness of the microchannel on the process of droplet generation in two-phase flows in a T-junction microchannel.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00716F, Paper
A simple paper fluidic device provides a visual indication of blood coagulation status.

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