Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.748 24 Issues per Year Indexed in MEDLINE
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A. F. Chrimes, I. Khodasevych, A. Mitchell, G. Rosengarten and K. Kalantar-zadeh
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01213E, Paper
We present a novel switchable Fresnel zone plate, created using nanoparticle suspensions which are controlled by dielectrophoresis.
G. Czilwik, I. Schwarz, M. Keller, S. Wadle, S. Zehnle, F. von Stetten, D. Mark, R. Zengerle and N. Paust
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01115E, Paper
Schematic view of fluidic structures with a liquid–air mixture a) the vapor–liquid equilibrium is rapidly reached by diffusion and convection in a closed cavity. b) A capillary prevents rapid propagation of vapor.
Juan Rodrigo Velez-Cordero, Misael G Pérez-Zúñiga and Juan Hernández-Cordero
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01389A, Paper
We demonstrate an optopneumatic piston based on glass capillaries, amixture of PDMS-carbon nanopowder, silicone andmineral oil. The fabrication method is based on wire coating techniques and surface tension driven instabilities,...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01018C, Paper
A method for the collection and concentration of molecules on arrays of metallic nanocones is presented, making use of the high electric field gradients at the nanotips. The nanocones are integrated into a microfluidic channel and used as nanoelectrodes. By applying an AC voltage, dielectrophoresis is used to capture molecules from the channel region on the nanocones.
Xu Shi, Chun-Hong Chen, Weimin Gao, Shih-hui Chao and Deirdre R. Meldrum
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01111B, Paper
Nucleic acid extraction is a necessary step for most genomic/transcriptomic analyses, but it often requires complicated mechanisms to be integrated into a lab-on-a-chip device.
Anja Kunze, James Che, Armin Karimi and Dino Di Carlo
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC90122C, Highlight
Microfluidic pipette tip for combined solution transfer and cell filtration – Physical separations for improved cell-based therapies – Separating cells from the living brain with nanomagnets.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01176G, Paper
In this paper, the design, development and validation of a novel high throughput microfluidic device enabling both the robust and rapid trapping of 100's to 1000's of single cells and their in situ clonal growth is described.
Andreas O. Stucki, Janick D. Stucki, Sean R. R. Hall, Marcel Felder, Yves Mermoud, Ralph A. Schmid, Thomas Geiser and Olivier T. Guenat
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01252F, Paper
From themed collection Open access articles from Lab on a Chip
The effects of respiration movements on primary lung cells from patients are investigated on an easy to handle lung-on-a-chip.
Hatice Ceylan Koydemir, Zoltan Gorocs, Derek Tseng, Bingen Cortazar, Steve Feng, Raymond Yan Lok Chan, Jordi Burbano, Euan McLeod and Aydogan Ozcan
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01358A, Paper
Rapid and sensitive detection of waterborne pathogens in drinkable and recreational water sources is crucial for treating and preventing the spread of water related diseases, especially in resource-limited settings. Here...
Isaac Rodríguez-Ruiz, Mayte Conejero-Muriel, Tobias Nils Ackermann, Jose A. Gavira and Andreu Llobera
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01332H, Paper
We propose a PDMS-based photonic system for the accurate measurement of protein concentration with minute amounts of sample. As opposed to the state of the art, in the multiple path...
Majid Hejazian, Weihua Li and Nam-Trung Nguyen
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01422G, Critical Review
Separation of cells is a key application area of lab-on-a-chip (LOC) devices. Among the various methods, magnetic separation of cells utilizing microfluidic devices offers the merits of biocompatibility, efficiency, and...
Ilke Akartuna, Donald A. Aubrecht, Thomas E. Kodger and David Alain Weitz
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01285B, Paper
We present a new microfluidic method to coalesce pairs of surfactant-stabilized water-in-fluorocarbon oil droplets. We achieve this through the local addition of a poor solvent for the surfactant, perfluorobutanol, which...
Christoph Faigle, Franziska Lautenschläger, Graeme Whyte, Philip Homewood, Estela Martin-Badosa and Jochen Guck
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01196A, Paper
The mechanical properties of biological cells have long been considered as inherent marker of biological function and disease. However, the screening and active sorting of heterogeneous populations based on serial...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01165A, Communication
A novel microfluidic protein digestion system with a nanostructured and bioactive inner surface was constructed for rapid protein digestion.
Matthias Mehling, Tino Frank, Cem Albayrak and Savaş Tay
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01038H, Paper
A microfluidic system for the study of T-cell chemotaxis and subsequent gene expression analysis.
Burcu Gumuscu, Johan G. Bomer, Albert van den Berg and Jan C. T. Eijkel
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01350F, Technical Innovation
From themed collection Open access articles from Lab on a Chip
Capillary barriers provide a simple and elegant means of autonomous fluid-flow control in microfluidic systems.
Zhuang Zhi Chong, Shu Beng Tor, Ngiap Hiang Loh, Teck Neng Wong, Alfonso M. Gañán-Calvo, Say Hwa Tan and Nam-Trung Nguyen
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01139B, Technical Innovation
We report a new technology using acoustofluidic to achieve controllable manipulation of the size of the bubbles formed.
Franklin I. Uba, Bo Hu, Kumuditha Weerakoon-Ratnayake, Nyote Oliver-Calixte and Steven A. Soper
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01254B, Paper
A low temperature hybrid assembly process for the production of functional thermoplastic nanofluidic devices with process yield rates >90% and an assembly time of 16 min is reported.
Thach Vuong, Brandon Huey-Ping Cheong, So Hung Huynh, Murat Muradoglu, Oi Wah Liew and Tuck Wah Ng
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01273A, Communication
An air logic system using a superhydrophobic well scheme allows open surface microfluidic transfer with low sample adhesion losses.
Dries Vercruysse, Alexandra Dusa, Richard Stahl, Geert Vanmeerbeeck, Koen Johannes Hubertus Gerardus de Wijs, Chengxun Liu, Dimiter Prodanov, Peter Peumans and Liesbet Lagae
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01131G, Paper
A compelling clinical need exists for inexpensive, portable, haematology analyzers that can be utilized at the point-of-care, in emergency settings or in resource-limited settings. Development of a label-free, microfluidic blood...
Zhengya Dong, Chaoqun Yao, Xiaoli Zhang, Jie Xu, Guangwen CHEN, Yuchao Zhao and Quan Yuan
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01431F, Paper
Combination of ultrasound and microreactor is an emerging and promising area, but the report of designing high-power ultrasonic microreactor (USMR) is still limited. This work presents a robust, high-power and...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01271B, Critical Review
We review the recent development in functional microphysiological models and present an outlook on the opportunities for translational development in immunology.
Reza Ghaemi, Pouya Rezai, Balaji Iyengar and Ponnambalam Ravi Selvaganapathy
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01245C, Paper
Two microfluidic devices (Pneumatic chip and FlexiChip) have been developed for immobilization and live-intact fluorescent functional imaging of Drosophila larva’s Central Nervous System (CNS) in response to controlled acoustic stimulation....
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01247J, Paper
A multi-layer scaffold incorporating dielectrophoresis for automated cell manipulation is developed to construct 3D cellular patterns for tissue engineering applications.
Eric Brouzes, Travis Kruse, Robert Kimmerling and Helmut H. Strey
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01327A, Paper
We manipulate the splitting profile due to asymmetric forks to improve the enrichment of magnetic beads extracted from flowing droplets.

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