Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
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Remo Friedrich, Stephan Block, Mohammadreza Alizadehheidari, Susanne Heider, Joachim Fritzsche, Elin K Esbjörner, Fredrik Westerlund and Marta Bally
Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C6LC01302C, Paper
We present a nanofluidic device for fluorescence-based detection and characterization of small lipid vesicles on a single particle basis. The device works like a nano flow cytometer where individual vesicles...
Hiroaki Suzuki, Kenta M Mistuno, Katsuyuki Shiroguchi, Mamiko Tsugane, Taiji Okano, Tetsuji Dohi and Tomoaki Tsuji
Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C6LC01313A, Technical Innovation
Herein we examined the extent of replicability of the PDMS microchamber device transferred from the mater mold with complex 3D structures fabricated via micro stereolithography. Due to the elastomeric property...
Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C6LC01333C, Paper
Cytology of sparingly available cell samples from both clinical and experimental settings would benefit from high-selectivity protein tools. To minimize cell handling losses in sparse samples, we design a multi-stage...
Jitao Zhang, Xuefei A. Nou, Hanyoup Kim and Giuliano Scarcelli
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01443G, Paper
A flow cytometry technique featuring the all-optical measurement of nuclear mechanical properties is developed by integrating Brillouin spectroscopy with microfluidics.
Gustav Svedberg, Yunjin Jeong, Hunjong Na, Jisung Jang, Peter Nilsson, Sunghoon Kwon, Jesper Gantelius and Helene Andersson Svahn
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01358A, Paper
Multiplexed, scanner-based colorimetric detection of autoantibodies in plasma was achieved using graphically encoded particles and gold nanoparticles.
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01401A, Paper
We characterized the dynamics of drug-loss in microfluidics, and provide a quantitative framework for the design of organ-on-a-chip for drug discovery.
Sarit Kipper, Ludmila Frolov, Ortal Guy, Michal Pellach, Yair Glick, Asaf Malichi, Binyamin A. Knisbacher, Efrat Barbiro-Michaely, Dorit Avrahami, Yehuda Yavets-Chen, Erez Y. Levanon and Doron Gerber
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01534D, Paper
A computerized semiautomatic aligner aligns multilayer devices comprising intricate microfeatures several-fold more accurately than manual alignment.
Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C6LC01226D, Paper
Calcific aortic valvular disease (CAVD) is the most prevalent valvular pathology in the United States. Development of a pharmacologic agent to slow, halt, or reverse calcification has proven unsuccessful as...
Yu-Cheng Chen, Qiushu Chen, Tingting Zhang, Wenjie Wang and Xudong Fan
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01457G, Paper
Highly versatile tissue laser platform.
Chengzhi Hu, Hannes Vogler, Marianne Aellen, Naveen Shamsudhin, Bumjin Jang, Jan T. Burri, Nino Läubli, Ueli Grossniklaus, Salvador Pané and Bradley J. Nelson
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01307D, Paper
We developed and characterized a microelectrode device used for studying the cellular repsonse of pollen tubes.
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01439A, Tutorial Review
This review describes the principles of optical DNA mapping in nanofluidic channels and highlights recent examples of exciting novel applications.
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01023G, Critical Review
Engineered microparticles fabricated through recently developed methods for biomedical applications.
Marco Serra, Iago Pereiro, Ayako Yamada, Jean-Louis Viovy, Stephanie Descroix and Davide Ferraro
Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C6LC01319H, Communication
The sealing of microfluidic devices remains a complex and time-consuming process requiring specific equipment and protocols: a universal method is thus highly desirable. We propose here the use of a...
Duc T. T. Phan, Xiaolin Wang, Brianna M. Craver, Agua Sobrino, Da Zhao, Jerry C. Chen, Lilian Y. N. Lee, Steven C. George, Abraham P. Lee and Christopher C. W. Hughes
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01422D, Paper
A vascularized, perfused organ-on-a-chip platform suitable for large-scale drug efficacy/toxicity screening.
Bruno Teste, Jerome Champ, Arturo Londono-Vallejo, Stéphanie Descroix, Laurent Malaquin, Jean-Louis Viovy, Irena Draskovic and Guillaume Mottet
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01535B, Paper
Chromatin immunoprecipitation assays in droplets based on a microfluidic platform combining nanoliter droplets, magnetic beads and magnetic tweezers.
Ning Shao, Jianwei Chen, Jiaying Hu, Rong Li, Dabing Zhang, Shujuan Guo, Junhou Hui, Peng Liu, Litao Yang and Sheng-ce Tao
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01330A, Paper
A [C with combining low line]apillary [A with combining low line]rray-based [L with combining low line]oop-mediated isothermal amplification for [M with combining low line]ultiplex visual detection of nucleic acids (CALM) platform realizes simple and rapid GMO monitoring.
Michael Mauk, Jinzhao Song, Haim H. Bau, Robert Gross, Frederic D. Bushman, Ronald G. Collman and Changchun Liu
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01239F, Critical Review
We review recent technical advances in molecular testing of HIV using microfluidic technology, including sample preparation, isothermal amplification and detection.
Andrew Christopher Hodgson, Christophe Merlin Verstreken, Cynthia L Fisher, Ulrich Keyser, Stefano Pagliara and Kevin Chalut
Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C6LC01308B, Paper
Cell nuclei experience and respond to a wide range of forces, both in vivo and in vitro. In order to characterize the nuclear response to physical stress, we developed a...
Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C6LC01411A, Paper
The formation of glial scar remains a significant barrier to the long term success of neural probes. Micromotion coupled with mechanical mismatch between the probe and tissue is believed to...
Shin-Hyun Kim, Jin Woong Kim, Jun-Cheol Cho and David A. Weitz
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC90129H, Correction
Yu Du, Ning Li, Hao Yang, Chunhua Luo, Yixin Gong, Chunfang Tong, Yuxin Gao, Shouqin Lü and Mian Long
Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C6LC01374K, Paper
Physiologically, four major types of hepatic cells, including liver sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, and hepatocytes, reside inside liver sinusoids and interact with flowing peripheral cells under...
Yangfan Chen, Ho Nam Chan, Sean Alan Michael, Yusheng Shen, Yin Chen, Qian Tian, Lu Huang and Hongkai Wu
Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C6LC01427E, Technical Innovation
The human circulatory system is comprised of a complex network of blood vessels interconnecting biologically relevant organs and a heart driving blood recirculation throughout this system. Recreating this system in...
Ziqiu Tong, Angela Ivask, Keying Guo, Scott McCormick, Enzo Lombi, Craig Priest and Nicolas H. Voelcker
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01261B, Paper
A crossed flow microfluidic device was used for generation of cell-based arrays aiming for high throughput screening of applied bioactive chemicals to captured cells.
Paulo A. Garcia, Zhifei Ge, Laura E. Kelley, Steven J. Holcomb and Cullen R. Buie
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01309K, Paper
From themed collection 2016 Lab on a Chip Emerging Investigators
Synthetic biology holds great potential for addressing pressing challenges for mankind and our planet.
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01238H, Paper
A valve-free, low cost 3D-printed device was designed for fast, low cost automated protein detection of PSA and PF-4 with a LOD of 0.5 pg mL−1 and a large dynamic range.

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81 citations
This review surveys the leading approaches for sorting cells in microfluidic devices and organizes those technologies by the many physical mechanisms exploited for sorting.
DOI: 10.1039/C4LC01246A
Published: 06 Jan 2015
56 citations
In this paper, a review is carried out of how 3D printing helps to improve the fabrication of microfluidic devices, the 3D printing technologies currently used for fabrication and the future of 3D printing in the field of microfluidics.
DOI: 10.1039/C5LC00685F
Published: 22 Jul 2015
57 citations
We established a microfluidic four-organ-chip for interconnected long-term co-culture of human intestine (1), liver (2), skin (3) and kidney (4) equivalents.
DOI: 10.1039/C5LC00392J
Published: 13 May 2015

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