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Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 6.115 24 Issues per Year Indexed in Medline
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Fupeng Liang, An Ju, Yi Qiao, Jing Guo, Haiqing Feng, Junji Li, Na Lu, Jing Tu and Zuhong Lu
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00152A, Technical Innovation
Comparing with microfluidic devices, fabrication of structure-controllable and designable nanochannel devices has been considered to have high cost and complex procedures, which requires expensive equipments and high-quality raw materials. Exploring...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01563D, Paper
Coculturing multiple cell types together in 3-dimensional (3D) cultures better mimics the in vivo microphysiological environment, and has become widely adopted in recent years with the development of organ-on-chip systems....
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01233C, Paper
From themed collection Optofluidics
Stationary and moving liquid-core/liquid-cladding optical waveguides were established with dielectrophoresis from electrowetting-created droplets.
Jungkyu Kim, Amanda Stockton, Erik Christian Jensen and Richard A. Mathies
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01397F, Critical Review
Programmable microfluidic platforms (PMPs) are enabling significant advances in the utility of microfluidics for chemical and biochemical analysis. Traditional microfluidic devices are analogous to application-specific devices – a new device...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01541C, Paper
We recently demonstrated direct observation of the micro-electrokinetic turbulence in a microchannel at low Reynolds number (Re), when a pressure driven flow was forced electrokinetically. Here we characterize the corresponding...
Alessandro Garziano, francesco urciuolo, Giorgia Imparato, Francesca Martorina, Brunella Corrado and Paolo Antonio Netti
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01481F, Paper
Tissue-on-chip (TOC) systems aim at replicating complex biological dynamics in vitro with the potential to improve the understanding of human biology or to develop effective therapeutic strategies. To faithfully replicate...
Haitao Yu, Ying Chen, Pengcheng Xu, Tiegang Xu, Yuyang Bao and Xinxin Li
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01187F, Paper
A μ-‘diving suit’ technology is developed to achieve long-time stable resonance of micro-cantilever sensors in solution for real-time bio/chemical detection.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01417D, Paper
The topography of thin films in microfluidic channels can be reconstructed at the nanometric scale from interference microscopy imaging by modelling the multiple reflections at the upper and the lower surfaces of the microchannel.
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01249J, Paper
From themed collection Optofluidics
We report a novel wash-free magnetic immunoassay technique for prostate-specific antigen (PSA) that uses a surface-enhanced Raman scattering (SERS)-based microdroplet sensor. The magnetic bar embedded in a droplet-based microfluidic system...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01365H, Paper
Lack of sensitivity is a major problem among microfluidic paper-based analytical devices (μPADs) for early disease detection and diagnosis. Accordingly, the present study presents a method for improving the enrichment...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01544H, Paper
We propose a novel neural probe which combines microfluidic channels with recording and stimulation electrodes. The developed microfabrication approach enables the concentration of every active element such as electrodes and...
Sarah M. Friedrich, Helena C. Zec and Tza-Huei Wang
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01294E, Critical Review
From themed collection Optofluidics
This review discusses recent advances in single molecule analysis of nucleic acid molecules within micro- and nano-fluidic environments.
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01478F, Paper
In a miniaturised flow switch fluid flows are controlled by reducing the local viscosity via absorption of laser radiation. By this local flow rates are increased to switch the outlet...
Jeong-ah Kim, Jinyoung Lee, Chueh-Yu Wu, Sung Min Nam, Dino Di Carlo and Wonhee Lee
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C5LC01100K, Paper
Inertial focusing in microfluidic channels has been extensively studied experimentally and theoretically, which has led to various applications including microfluidic separation and enrichment of cells. Inertial lift forces are strongly...
Yun Chen, Zecong Fang, Brett Merritt, Dillon Strack, Jie Xu and Sungyon Lee
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01420D, Paper
We quantitatively analyze the secondary radiation force of an acoustic bubble for particle trapping and release in a flow.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01151E, Paper
A standalone microfluidic chip allows to carry out an antibiotic susceptibility test with an automatic pipette and with minimum manual labour.
Chao Liu, Chundong Xue, Jiashu Sun and Guoqing Hu
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01522G, Paper
We propose a fitting formula for the inertial lift on a sphere drawn from direct numerical simulation data obtained in straight microchannels. The formula consists of four terms that represent the shear-gradient-induced lift, the wall-induced lift, the slip-shear lift, and the correction of the shear-gradient-induced lift, respectively.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01207D, Paper
We present a two-stage immunosensor for pathogen detection in a mixed population.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01413A, Paper
The effects of molecular confinement and crowding on enzyme kinetics were studied at length scales and under conditions similar to those found in biological cells.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01392E, Paper
We present a low-cost, disposable, and fully-integrated paperfluidic molecular diagnostic chip for sample-to-result functionality at the point-of-care.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01526J, Paper
We report a microfluidic method for generation and studying model chemical networks comprising multiple communicating liquid compartments.
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01533B, Paper
A novel thermal digital microfluidic (T-DMF) device enables precise thermal modulation and pipelined measurement of multiple samples. Ultrafast DNA melting curve analysis is achieved in less than 7 seconds, with the resolution adequate for single-nucleotide discrimination.
E. J. Vrij, S. Espinoza, M. Heilig, A. Kolew, M. Schneider, C. A. van Blitterswijk, R. K. Truckenmüller and N. C. Rivron
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01499A, Paper
We present a micro-thermoformed microwell screening plate and identify cAMP as a regulator of primitive endoderm formation in embryoid bodies.
M. Fouet, M.-A. Mader, S. Iraïn, Z. Yanha, A. Naillon, S. Cargou, A.-M. Gué and P. Joseph
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC00941C, Paper
We push the limits of hydrodynamic filtration by demonstrating filter-less sorting of submicron particles, in line with the model and simulations.
Vishal Tandon, Woo Seok Kang, Tremaan A. Robbins, Abigail J. Spencer, Ernest S. Kim, Michael J. McKenna, Sharon G. Kujawa, Jason Fiering, Erin E. L. Pararas, Mark J. Mescher, William F. Sewell and Jeffrey T. Borenstein
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01396H, Paper
From themed collection Lab on a Chip Recent HOT Articles
We fabricated a micropump for reciprocating, zero-net-volume intracochlear drug delivery.

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