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Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 6.115 24 Issues per Year Indexed in Medline
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Gregor Czilwik, Thorsten Messinger, Oliver Strohmeier, Simon Wadle, Felix von Stetten, Nils Paust, Günter Roth, Roland Zengerle, Petri Saarinen, Jaana Niittymaki, Katherine McAllister, Orla Sheils, John J. O’Leary and Daniel Mark
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00591D, Paper
Diagnosis of infectious diseases suffers from long turnaround times for gold standard culture-based identification of bacterial pathogens, therefore impeding timely specific antimicrobial treatment based on laboratory evidence. Rapid molecular diagnostics-based...
Andreas Winkler, Stefan M Harazim, Siegfried B Menzel and Hagen Schmidt
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00756A, Paper
Surface acoustic wave (SAW) based fluid atomizers are ideally suited to generate micrometer-sized droplets without any moving parts or nozzles. Versatile application fields can be found for instance in biomedical,...
W. Espulgar, W. Aoki, T. Ikeuchi, D. Mita, M. Saito, J.-K. Lee and E. Tamiya
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00652J, Paper
Single-cell level drug profiling application of isolated single and groups of neonatal rat cardiomyocytes trapped by centrifugal force.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00611B, Critical Review
The liver, the largest organ in the human body, is a multi-functional organ with diverse metabolic activities that plays a critical role in maintaining the body and sustaining life. Although...
Thanh-Vinh Nguyen, Minh-Dung Nguyen, Hidetoshi Takahashi, Kiyoshi Matsumoto and Isao Shimoyama
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00661A, Paper
We report a simple technique to measure the free vibration of microlitre-sized droplets using an array of thirteen MEMS-based piezoresistive cantilevers and demonstrate its application for the measurement of viscosity....
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00651A, Paper
We present a programmable microfluidic static droplet array (SDA) device that can perform user-defined multistep combinatorial protocols. It combines the passive storage of aqueous droplets without any external control with...
Edward W Tekwa, Dao Nguyen, David Juncker, Michel Loreau and Andrew Gonzalez
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00576K, Paper
Localized interactions are predicted to favour the evolution of cooperation amongst individuals within a population. One important factor that can localize interactions is habitat patchiness. We hypothesize that habitats with...
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00370A, Paper
Ultrasound contrast agent (UCA) suspensions contain encapsulated microbubbles with a wide size distribution, with radii between 1 and 10
Rune Barnkob, Christian J. Kähler and Massimiliano Rossi
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00562K, Paper
The General Defocusing Particle Tracking (GDPT) is a 3D particle tracking method that relies on a simple empirical procedure based on a calibration image stack and the normalized cross-correlation function. The method is intuitive and easy to use and can be applied on defocused particle images of arbitrary shapes.
Mehrije Ferizi, Carolin Leonhardt, Christian Meggle, Manish K. Aneja, Carsten Rudolph, Christian Plank and Joachim O. Rädler
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00749F, Paper
Micro-structured arrays allow highly parallel assessment of single-cell mRNA-mediated dsGFP-expression time courses. Fits to the individual expression kinetics yield mRNA life-time distribution, which are compared for differently stabilized mRNA constructs.
Chee Meng Benjamin Ho, Sum Huan Gary Ng, King Ho Holden Li and Yong-Jin Yoon
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00685F, Critical Review
The term ‘‘Lab-on-a-Chip,’’ is synonymous to describing microfluidic devices with biomedical applications. Even though Microfluidics have been developing rapidly for the past decade, the uptake rate in biological research has...
Li Lu, Jeffrey W Schertzer and Paul R Chiarot
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00520E, Paper
We report on a novel microfluidic strategy for the continuous fabrication of monodisperse asymmetric vesicles with customized membrane composition, size, and luminal content. The microfluidic device encompasses a triangular post...
Xinjie Zhang, Nan Xiang, Wenlai Tang, Di Huang, Xin Wang, Hong Yi and Zhonghua Ni
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00647C, Paper
This paper presents a novel passive flow regulator for steady and high-throughput inertial isolation of differently sized microbeads.
Ying Yi, Ulrich Buttner and Ian G. Foulds
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00703H, Paper
This work, focusing on an implantable drug delivery system, presents the first prototype electrolytic pump that combines a catalytic reformer and a cyclically actuated mode.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00558B, Paper
Primary, secondary and tertiary vortices generated inside an ion concentration polarization (ICP) region all rotating in the same direction.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00598A, Paper
This paper reports a novel hydrodynamic technique for sorting of droplets and cells based on size and deformability. The device comprises two modules: focusing and spacing control module and sorting...
Susan Helena Roelofs, Albert van den Berg and Mathieu Odijk
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00481K, Critical Review
In this review we discuss recent developments in the emerging research field of miniaturized desalination. Traditionally desalination is performed to convert salt water into potable water and research is focused...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00458F, Paper
Here, we present a Lab-on-a-Chip system for DNA Methylation Analysis based on Bisulfite conversion (LoMA-B), which is coupled to a sample pre-processing module for on-chip bisulfite conversion and a label-free, real-time detection module for rapid analysis of DNA methylation status.
Hyogeun Shin, Hyunjoo Jenny Lee, Uikyu Chae, Huiyoung Kim, Jeongyeon Kim, Nakwon Choi, Jiwan Woo, Yakdol Cho, Changjoon Justin Lee, Eui-Sung Yoon and Il-Joo Cho
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00582E, Paper
Multi-functional neural probes are promising platforms to conduct efficient and effective in-depth studies of brain by recording neural signals as well as modulating the signals with various stimuli. Here we...
Rui Dou, Rachel E. Saunders, Lisa Mohamet, Christopher M. Ward and Brian Derby
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00674K, Paper
We have successfully used inkjet printing to cryopreserve 3T3 mouse fibroblast cells and human neuroprogenitor cells (NPCs) derived from human embryonic stem cells (hESCs).
Tiffany Guo, Ritish Patnaik, Kevin Kuhlmann, Alex J. Rai and Samuel K. Sia
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00609K, Paper
In this work, we demonstrate a microfluidic-based smartphone dongle that simultaneously measures concentration of hemoglobin and detects HIV antibodies.
Luis F. Alonzo, Monica L. Moya, Venktesh S. Shirure and Steven C. George
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00507H, Paper
To address the gap between in vivo microenvironments and in vitro systems, we have developed a novel microfluidic device that precisely controls the spatial and temporal interactions between adjacent three-dimensional cellular environments.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00315F, Paper
Perfluorocarbon (PFC) nanodroplet agents are exciting new biomaterials that can be remotely vapourized by ultrasound or light to change into micron-scale gas bubbles in situ. After PFC nanodroplet vapourization, the...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00523J, Paper
The direct coupling of free-flow isotachophoresis device with an electrospray-ionization-mass-spectrometer allows continuous online detection without any sample preparation such as purification and labeling.
Hardik J Pandya, Kihan Park, Wenjin Chen, Marina A. Chekmareva, David J. Foran and Jaydev Desai
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00491H, Paper
Carcinomas are the most commonly diagnosed cancers originating in the skin, lungs, breasts, pancreas, and other organs and glands. In most of the cases, the microenvironment within the tissue changes...

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