Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.748 24 Issues per Year Indexed in MEDLINE
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Kumi Y. Inoue, Masahki Matsudaira, Masanori Nakano, Kosuke Ino, Chika Sakamoto, Yusuke Kanno, Reyushi Kubo, Ryota Kunikata, Atsushi Kira, Atsushi Suda, Ryota Tsurumi, Toshihito Shioya, Shinya Yoshida, Masanori Muroyama, Tomohiro Ishikawa, Hitoshi Shiku, Shiro Satoh and Masayoshi Esashi
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01099J, Paper
We develop an advanced version of large-scale integration (LSI)-based amperometric sensing system with a 400-electrode array for real-time bioimaging and simultaneous multi-point biosensing (Bio-LSI). Two major improvements allow the Bio-LSI...
zhenzhen li, Alexander Leshansky, Patrick Tabeling and Len Pismen
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01289E, Paper
We present a comprehensive study of the step-emulsification process for high-throughput production of colloidal monodisperse droplets. The `microfluidic step emulsifier' combines a shallow microchannel operating with two co-flowing immiscible fluids...
Marie Leman, Faris Abouakil, Andrew D. Griffiths and Patrick Tabeling
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01122H, Paper
Standard operations of droplet-based microfluidic were miniaturized down to the femtolitre scale. The level of control is maintained despite the three order of magnitude reduction in droplet volume.
Thach Vuong, Brandon Huey Ping Cheong, So Hung Huynh, Murat Muradoglu, Oi Wah Liew and Tuck Wah Ng
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01273A, Communication
Superhydrophobic surfaces aid biochemical analysis by limiting sample loss. A system based on wells here tolerated tilting of up to 20o and allowed air logic transfer with evidences of mixing....
Lian Yi, Xue Wang, Raghuram Dhumpa, Adrian Mark Schrell, Nikita Mukhitov and Michael G Roper
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01360C, Paper
A microfluidic system was developed to investigate the entrainment of insulin secretion from islets of Langerhans to oscillatory glucose levels. A gravity-driven perfusion system was integrated with a microfluidic system...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01319K, Paper
In this work, we report a novel design of a passively-controlled, finger-driven microfluidic circuit for the metering and delivery (MaD) of liquid reagent. The proposed design modularized the fluidic circuit...
Yunkyoung Choi, Heonsu Jeon and Sunghwan Kim
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01171F, Communication
A fully biocompatible laser would be attractive in many aspects of biomedical research.
Mathieu Odijk, Andries D. van der Meer, Daniel Levner, Hyun Jung Kim, Marinke W. van der Helm, Loes I. Segerink, Jean-Phillipe Frimat, Geraldine A. Hamilton, Donald E. Ingber and Albert van den Berg
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01219D, Paper
TEER measurements are ideal for characterizing tissue barrier function in organs-on-chip studies for drug testing and investigation of human disease models; however, published reports indicate highly conflicting results even with identical cell lines and setups.
Yamin Yang, Xiaochuan Yang, Jin Zou, Chao Jia, Yue Hu, Henry Du and Hongjun Wang
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01065E, Paper
A microfluidic-based in vitro three-dimensional (3D) breast cancer tissue model was established for determining the efficiency of photodynamic therapy (PDT) with therapeutic agents (photosensitizer and gold nanoparticles) under various irradiation conditions.
Matthias Blazek, Tomas Silva Santisteban, Roland Zengerle and Matthias Meier
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00797B, Paper
In the present study, we developed a microfluidic large-scale integration (mLSI) platform for the temporal and chemical control of cell cultures to study fast kinetics of protein phosphorylation.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC90120G, Editorial
Harp Minhas, Executive Editor of Lab on a Chip discusses the important role that teamwork has played in the success of the journal.
Abraham K. Badu-Tawiah, Shefali Lathwal, Kaja Kaastrup, Mohammad Al-Sayah, Dionysios C. Christodouleas, Barbara S. Smith, George M. Whitesides and Hadley D. Sikes
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01239A, Technical Innovation
Polymerization-based signal amplification is combined with an immunoassay for detection of a malaria antigen (PfHRP2) at paper surfaces.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01033G, Paper
In this paper, we demonstrated an integrated centrifugal microdevice which could perform reverse transcriptase loop-mediated isothermal amplification and immunochromatographic strip based amplicon analysis for rapid, sensitive, and multiplex influenza A virus detection.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01046A, Paper
A microfluidic device is designed and used to investigate interfacial polymerization film formation in situ.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00943F, Paper
Microsecond-laser-pulse-induced microbubbles can porate specific single cells on demand at up to 95% efficiency, including the delivery of plasmids and multiple types of payloads.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00884G, Communication
We developed a micropatterned photodegradable hydrogel array integrated with reconfigurable microfluidics to enable cell secretion analysis and cell retrieval at the single-cell level.
Bo Jiang, Julien Haber, Albert Renken, Paul Muralt, Lioubov Kiwi-Minsker and Thomas Maeder
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01105H, Paper
We developed a novel low-temperature co-fired ceramic (LTCC) microfabrication method for making microreactors with complex fluidic structures for applications involving harsh chemicals and envir`onmental processes.
Hyesung Cho, Junsoo Kim, Keishi Suga, Takaaki Ishigami, Hyunchul Park, Jung Won Bang, Soonmin Seo, Mansoo Choi, Pahn-Shick Chang, Hiroshi Umakoshi, Ho-Sup Jung and Kahp-Yang Suh
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01096E, Communication
We fabricated a simple yet robust microfluidic platform with monolithically integrated hierarchical apertures.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01032A, Communication
We present a novel process to encapsulate Indocyanine Green (ICG) in liposomal droplets at high concentration for potential applications in image-guided drug delivery. The microencapsulation process follows two consecutive steps...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01290A, Paper
We demonstrate an active, implantable drug delivery device embedded with a microfluidic pump that is driven by a radio-controlled actuator for temporal drug delivery. The polyimide-packaged 10×10×2 mm3 chip contains...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01277A, Paper
We present a novel method for the generation of giant unilamellar vesicles and the use of fluctuation analysis to characterise their mechanical properties.
Lisa Drechsel, Martin Schulz, Felix von Stetten, Carmen Moldovan, Roland Zengerle and Nils Paust
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01214C, Paper
A ball-pen mechanism incorporated into a disposable cartridge mediates dipping of a biosensor into the sample and reagents.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01268B, Technical Innovation
A combination of cutting edge developments is presented to characterize three-dimensional (3D) temperature and velocity fields in microscopic flows. An emulsion of non-encapsulated thermo-liquid crystal (TLC) micro spheres, with a...
Donghyuk Kim, Qingshan Wei, Janay Elise Kong, Aydogan Ozcan and Dino Di Carlo
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC90119C, Highlight
Digital measurement with a high dynamic range – Are digital nucleic acid assays more robust? – Digital measurement of membrane transporter proteins.
Alexander J. Aranyosi, Elisabeth A. Wong and Daniel Irimia
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00970C, Paper
A system that accomplishes a function analogous to a treadmill at the cellular scale helps decouple the spatial and temporal gradients during neutrophil chemotaxis.

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