Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.697 24 Issues per Year Indexed in MEDLINE
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Jun Ho Son, Sang Hun Lee, SoonGweon Hong, Seung-min Park, Joseph Lee, Andrea M. Dickey and Luke P Lee
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00149D, Paper
Hemolysis, involving the rupture of red blood cells (RBCs) and release of their contents into blood plasma, is a major issue of concern in clinical fields. Hemolysis in vitro can...
Yi-Meng Sun, Wei Wang, Yun-Yan Wei, Nan-Nan Deng, Zhuang Liu, Xiao-Jie Ju, Rui Xie and Liang-Yin Chu
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00273C, Paper
Here we report on a simple and versatile strategy for in situ fabrication of nanogel-containing smart membranes in the microchannel of microchips. The fabrication approach is demonstrated by in situ...
Jason D. McNulty, Tyler Klann, Jin Sha, Max Salick, Gavin T. Knight, Lih-Sheng Turng and Randolph S. Ashton
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51137E, Paper
R-μCP enables automated manufacture of complex cell culture substrates using superimposed μCP steps and periodic substrate removal while maintaining microscale precision.
Linn Petersson, Linda Dexlin-Mellby, Anders A. Bengtsson, Gunnar Sturfelt, Carl A. K. Borrebaeck and Christer Wingren
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51420J, Paper
Miniaturization of multiplexed recombinant antibody microarrays for protein expression profiling of crude proteomes.
Meltem Elitas, Rodrigo Martinez-Duarte, Neeraj Dhar, John D. McKinney and Philippe Renaud
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00109E, Paper
This paper describes the ability for dielectrophoresis to enrich and recover antibiotic-treated mycobacteria, based on physico-chemical properties of their membranes.
Sertan Sukas, Erik Schreuder, Bjorn de Wagenaar, Joost Swennenhuis, Albert van den Berg, Leon Terstappen and Séverine Le Gac
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51433A, Technical Innovation
We present a novel coplanar side electrode configuration integrated in fused silica devices for synchronous electrical and optical measurements.
Björn Harink, Séverine Le Gac, David Barata, Clemens van Blitterswijk and Pamela Habibovic
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00190G, Technical Innovation
Microtiter plate-sized standalone chip holder for control of physiological conditions inside closed microfluidic cell culture systems, made from gas-impermeable materials.
Hongbo Zhou, Gang Li and Shuhuai Yao
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51442K, Paper
A stable microenvironment with pH ranging from 3 to 11 is achieved by on-demand control of droplet formation and electrolysis.
Petra Paiè, Francesca Bragheri, Rebeca Martinez Vazquez and Roberto Osellame
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00133H, Paper
A femtosecond laser fabricated microfluidic module for 3D hydrodynamic focusing allows confinement of fluids to a tight area in the channel center.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00023D, Paper
Fascicle-inspired tissue strips were generated having high (~100 s) length to diameter ratios using a novel external sacrificial molding method. High levels of alignment, 3D cell distribution, and cell density are demonstrated.
Anushi Rajapaksa, Aisha Qi, Leslie Y. Yeo, Ross Coppel and James R. Friend
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00232F, Paper
A practical, commercially viable microfluidic device relies upon the miniaturization and integration of all its components—including pumps, circuitry, and power supply—onto a chip-based platform.
Matthew P Horning, Charles Delahunt, S Ryan Singh, Spencer H Garing and Kevin P Nichols
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00293H, Paper
A paper microfluidic cartridge for the automated staining of malaria parasites (Plasmodium) with acridine orange prior to microscopy is presented. The cartridge enables simultaneous, sub-minute generation of both thin and...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00197D, Paper
We report the design, the fabrication and evaluation of an array of microdevices composed of high aspect ratio PDMS pillars, dedicated to the study of tumour spheroid mechanical properties. The...
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00015C, Paper
Chitosan/cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG ODN) nanoparticles as potential immunostimulatory adjuvants were synthesized by the conventional bulk mixing (BM) method and a novel microfluidic (MF) method.
Wei Liu, Yaqian Li, Siyu Feng, Jia Ning, Jingyu Wang, Maling Gou, Huijun Chen, Feng Xu and Yanan Du
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00081A, Paper
Microtissues on the scale of several hundred microns are a promising cell culture configuration resembling the functional tissue units in vivo.
Il Hyung Shin, Ki-jung Kim, Jiman Kim, Hee Chan Kim and Honggu Chun
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00024B, Technical Innovation
A cation-selective microfluidic sample preconcentration system is described using anion-permselective TMSVE- or polyE-323-coated nanochannels or a positively charged nanoporous polymer (PDADMAC) placed between positively-surface-coated microchannels.
Tim Femmer, Alexander Kuehne and Matthias Wessling
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00320A, Technical Innovation
Polydimethylsiloxane is a translucent and biologically inert silicone material used in sealants, biomedical implants and microscale lab-on-a-chip devices. Furthermore, in membrane technology polydimethylsiloxane represents a material for separation barriers as...
Christian Rensch, Simon Lindner, Ruben Salvamoser, Stephanie Leidner, Christoph Böld, Victor Samper, David Taylor, Marko Baller, Stefan Riese, Carmen Wängler and Björn Wängler
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00076E, Paper
The application of microfluidics to the synthesis of Positron Emission Tomography (PET) tracers has been explored for more than a decade. Microfluidic benefits such as superior temperature control have been...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00162A, Paper
A deep understanding of the mechanisms behind neurite polarization and axon path-finding is important for interpreting how the human body guides neurite growth during development and response to injury. Further,...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00192C, Paper
The deposition of asphaltenes in porous media, an important problem in science and macromolecular engineering, was for the first time investigated in a transparent packed-bed microreactor (μPBR) with online analytics...
Jayda L. Erkal, Asmira Selimovic, Bethany C. Gross, Sarah Y Lockwood, Eric Walton, Stephen McNamara, R. Scott Martin and Dana Spence
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00171K, Paper
We report two, 3D printed devices that can be used for electrochemical detection. In both cases, the electrode is housed in commercially available, polymer-based fittings so that the various electrode...
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00150H, Paper
DNA methylation is an epigenetic modification essential for normal development and maintenance of somatic biological functions. DNA methylation provides heritable, long-term chromatin regulation and aberrant methylation pattern is associated with...
Zhifeng Lin, Yuhong Ma, Changwen Zhao, Ruichao Chen, Xing Zhu, Lihua Zhang, Xu Yan and Wantai Yang
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00223G, Paper
Protein microarrays have become vital tools for various applications in biomedicine and bio-analysis during the past decade. The intense requirements for a lower detection limit and industrialization in this area...
Vittorio Bianco, Francesco Merola, Lisa Miccio, Pasquale Memmolo, Oriella Gennari, Melania Paturzo, Paolo Antonio Netti and Pietro Ferraro
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00290C, Paper
Imaging through turbid media is a challenging topic. A liquid is considered turbid when dispersed particles provoke strong light scattering, thus destroying the image formation by any standard optical system....
Carson T. Riche, Chuchu Zhang, Malancha Gupta and Noah Malmstadt
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00087K, Paper
Vapor deposited fluoropolymer coatings enabled extraction-induced merging of droplets and high frequency generation of droplets within PDMS microfluidic devices.

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