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Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 6.115 24 Issues per Year Indexed in Medline
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Eyad M Hamad, Stanley E.R. Bilatto, Nouran Y Adly, Daniel Correa, Bernhard Wolfrum, Michael J. Schoening, Andreas Offenhäusser and Alexey Yakushenko
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC01195G, Technical Innovation
Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for lab-on-a-chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is...
F. Stumpf, F. Schwemmer, T. Hutzenlaub, D. Baumann, O. Strohmeier, G. Dingemanns, G. Simons, C. Sager, L. Plobner, F. von Stetten, R. Zengerle and D. Mark
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC00871A, Paper
Sample supply remains the only manual handling step for pathogen detection at the point-of-care.
S. Burger, M. Schulz, F. von Stetten, R. Zengerle and N. Paust
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01280E, Paper
Rigorous mixing is achieved in a centrifugal microfluidic mixing chamber by inserting gas bubbles that rise rapidly due to increased buoyancy.
Hesam Babahosseini, Vaishnavi Srinivasaraghavan, Zongmin Zhao, Frank Gillam, Elizabeth Childress, Jeannine S. Strobl, Webster L. Santos, Chenming Zhang and Masoud Agah
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01201E, Paper
From themed collection Nanoengineering for Medicine and Biology (NEMB 2015)
A microfluidic chip developed to study the effects of free-drug versus NPs-mediated drug delivery on cancer cells using their electromechanical biomarkers.
Friedrich Schuler, Martin Trotter, Marcel Geltman, Frank Schwemmer, Simon Wadle, Elena Domínguez-Garrido, María López, Cristina Cervera-Acedo, Paula Santibáñez, Felix von Stetten, Roland Zengerle and Nils Paust
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01068C, Paper
An integrated digital droplet PCR system is presented that enables droplet generation, PCR amplification, and readout within a single reaction chamber on a centrifugal microfluidic LabDisk.
Wesley A. Cox-Muranami, Edward L. Nelson, G. P. Li and Mark Bachman
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01131K, Paper
Large area magnetic micropallets with ferromagnetic cores were fabricated on translucent gold thin films enabling consistent laser release of individual cell colonies via vapor bubble formation beneath the pallets.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC01323B, Communication
Multiplex expansion in point-of-care diagnostics usually requires a linear increase of premium commodities such as reagents or space. Here we demonstrate the power of binary and molecular encoding to compress...
Olaf Wagner, Julian Thiele, Marie Weinhart, Linas Mazutis, David A. Weitz, Wilhelm Huck and Rainer Haag
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC00823A, Technical Innovation
In droplet-based microfluidics, non-ionic, high-molecular weight surfactants are required to stabilize droplet interfaces. One of the most common structures that impart stability as well as biocompatibility to water-in-oil droplets is...
Hoon Suk Rho, Yoonsun Yang, Alexander Thomas Hanke, Marcel Ottens, Leon Terstappen and (Han) J G E Gardeniers
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC01206F, Paper
A new microfluidic valve or “v-type valve” which can be flexibly actuated to focus a fluid flow and block a specific area of a microchannel is demonstrated. Valves with different...
Niall P. MacDonald, Zhu Feng, Chris Hall, Julien Reboud, Kathryn Crosier, Phil Crosier, Elizabeth Patton, Donald Wlodkowic and Jonathan M Cooper
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC01374G, Paper
3D printing has emerged as a rapid and cost-efficient manufacturing technique to enable the fabrication of bespoke, complex prototypes. If the technology is to have a significant impact in biomedical...
Sukru U. Senveli, Zheng Ao, Siddarth Rawal, Ram H. Datar, Richard J. Cote and Onur Tigli
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01212K, Paper
Tumour cells are acoustically interrogated using Rayleigh type SAW devices where an embedded microcavity facilitates direct interaction between the cells and the surface waves.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC01117E, Paper
Tumor-derived circulating exosomes, enriched with a group of tumor antigens, have been recognized as a promising biomarker source for cancer diagnosis via less invasive procedure. Quantitatively pinpointing exosome tumor markers...
Jonas Hansson, Hiroki Yasuga, Tommy Haraldsson and Wouter van der Wijngaart
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC01318F, Paper
We introduce Synthetic Microfluidic Paper, a novel porous material for microfluidic applications that consists of OSTE polymer that is photostructured in a well-controlled geometry of slanted and interlocked micropillars. We...
Aereas Aung, Ivneet Singh Bhullar, Jomkuan Theprungsirikul, Shruti Krishna Davey, Han Liang Lim, Yu-Jui Chiu, Xuanyi Ma, Sukriti Dewan, Yu-Hwa Lo, Andrew McCulloch and Shyni Varghese
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC00820D, Paper
We present the development of three-dimensional (3D) cardiac microtissues within a microfluidic device with the ability to quantify real-time contractile stress measurements in situ.
Zhifei Ge, Peter R. Girguis and Cullen R. Buie
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC00978B, Paper
Nanoporous microscale microbial incubators allow communities of microbes to grow in physical isolation while maintaining chemical communication, facilitating the study of interactions within diverse communities.
Qingming Chen, Aoqun Jian, Zhaohui Li and Xuming Zhang
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01163A, Paper
We report a new design of optofluidic tunable lens with a 2D refractive index gradient generated by shining light onto a pair of metal strips.
A. Spencer, C. Spruell, S. Nandi, M. Wong, M. Creixell and A. B. Baker
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC00994D, Paper
A high throughput cone-and-plate device enabling the parallel application of flow for performing drug screening assays on tumor cell adhesion.
Jun Zhang, Sheng Yan, Dan Yuan, Gursel Alici, Nam-Trung Nguyen, Majid Ebrahimi Warkiani and Weihua Li
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01159K, Critical Review
From themed collection Lab on a Chip Recent HOT Articles
We provide a comprehensive review describing the fundamental mechanisms of inertial microfluidics, structure design and applications in biology, medicine and industry.
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC01005E, Technical Innovation
Here, we report the novel application of a material with self-concentrating properties for enhancing the sensitivity of immunoassays. Termed as glass microbubbles, they are antibody functionalized buoyant hollow glass microspheres...
Xiaolin Wang, Duc T. T. Phan, Steven C George, Christopher Hughes and Abraham Lee
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC01050K, Paper
This paper reports a method for generating an intact and perfusable microvascular network that connects to microfluidic channels without appreciable leakage. This platform incorporates different stages of vascular development including...
Lab Chip, 2015, Accepted Manuscript
DOI: 10.1039/C5LC01335F, Paper
High-speed sorting is an essential process in a number of clinical and research applications, where single cells, droplets and particles are segregated based on their properties in a continuous flow....
Kerwin Kwek Zeming, Nitish V. Thakor, Yong Zhang and Chia-Hung Chen
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01051A, Paper
Real-time nanoparticle separation in deterministic lateral displacement can be achieved by manipulating solution iconicity.
Bin Zhuang, Junping Han, Guangxin Xiang, Wupeng Gan, Shuaiqin Wang, Dong Wang, Lei Wang, Jing Sun, Cai-Xia Li and Peng Liu
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01094B, Paper
A fully integrated and automated microsystem consisting of disposable plastic chips for DNA extraction and PCR coupled with a reusable glass array-CE chip for rapid pharmacogenetic testing.
Kyungsup Han, Yong-Jin Yoon, Yong Shin and Mi Kyoung Park
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC00891C, Paper
We have developed a Self-powered Switch-controlled Nucleic acid Extraction System (SSNES) to overcome the limitation of LOC technology in POC applications. The SSNES have a potential to be widely used as powerless, fully-disposable and user-friendly system for DNA extraction.
Chiara Martino, Cyril Statzer, Daniele Vigolo and Andrew J. deMello
Lab Chip, 2016, Advance Article
DOI: 10.1039/C5LC01150G, Technical Innovation
Herein we demonstrate the segmentation of alginate solution streams to generate alginate fibers of precisely controllable lengths between 200 and 1000 μm.

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