Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.748 24 Issues per Year Indexed in MEDLINE
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Ravi Sinha, Séverine Le Gac, Nico Verdonschot, Albert van den Berg, Bart Koopman and Jeroen Rouwkema
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01259C, Paper
We report a medium throughput device to study the effects of combinations of two mechanical stimuli – surface strains and fluid flow shear stresses, on cells. The first generation prototype...
Camille Duprat, Hélène Berthet, Jason S. Wexler, Olivia du Roure and Anke Lindner
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01034E, Paper
An in situ method to tune and measure the mechanical properties of photo-polymerized gels.
Hong Yan Song, Ten It Wong, Anton Sadovoy, Lin Wu, Ping Bai, Jie Deng, Shifeng Guo, Yi Wang, Wolfgang Knoll and Xiaodong Zhou
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00978A, Paper
Schematic representation of our immunodetection set-up, which uses a Nikon Ti Eclipse microscope to detect the plasmonic nanochip with quantum dot based bioassay established.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01218F, Paper
A simple microfluidic device based on a microfluidic pipette array was developed for mechanical characterization of cells.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01027B, Technical Innovation
A holed-designed PDMS membrane is proposed as an innovative microarray spotter exploiting a vacuum procedure and verifying a good level of reproducibility of spotting fluorescent proteins over large areas.
Steve C. C. Shih, Philip C. Gach, Jess Sustarich, Blake A. Simmons, Paul D. Adams, Seema Singh and Anup K. Singh
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00794H, Paper
We have developed a new hybrid droplet-to-digital microfluidic platform (D2D) that integrates droplet-in-channel microfluidics with digital microfluidics for performing multi-step single cell assays.
Philipp Rinklin, Dzmitry Afanasenkau, Simone Wiegand, Andreas Offenhäusser and Bernhard Wolfrum
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00805G, Paper
Electrical heating of microstructured conductors is used to induce highly resolved lesions in confluent layers of cardiomyocytes.
Janay Elise Kong, Soroush Kahkeshani, Ivan Pushkarsky and Dino Di Carlo
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC90107J, Highlight
Dialysis-like therapeutic – Microfluidic capture of therapeutic cells from blood – Engineered injectable microscale cell niches for cell therapy.
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00937A, Paper
A self-powered one-touch blood extraction system is fabricated by the integration of a smart polymer-capped hollow microneedle and a pre-vacuum actuator. It is well suited for integration with other microsystems to realize a real-time micro total analysis for point-of-care diagnosis.
Xiaolong Qiu, Janice De Jesus, Marissa Pennell, Marco Troiani and Jered Brackston Haun
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01126K, Paper
Tumors tissues house a diverse array of cell types, requiring powerful cell-based analysis methods to characterize different cell subtypes. Tumor tissue is dissociated into single cells by treatment with proteolytic...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01194E, Communication
By gradually deflecting droplets into the appropriate channel, a “gapped divider” allows ten-fold faster sorting over other reported methods.
O. Cakmak, E. Ermek, N. Kilinc, S. Bulut, I. Baris, I. H. Kavakli, G. G. Yaralioglu and Hakan Urey
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00809J, Paper
A new cantilever-based system enabling multiple coagulation tests on the same disposable cartridge is demonstrated.
Gungun Lin, Denys Makarov, Mariana Medina-Sánchez, Maria Guix, Larysa Baraban, Gianaurelio Cuniberti and Oliver G. Schmidt
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01160K, Paper
A magnetofluidic platform with integrated GMR sensors is demonstrated for on-demand facile generation and high-throughput real-time decoding of droplet barcodes.
Paul Rademeyer, Dario Carugo, Jeong Yu Lee and Eleanor Stride
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01206B, Paper
Echogenic particles, such as microbubbles and volatile liquid micro/nano droplets, have shown considerable potential in a variety of clinical diagnostic and therapeutic applications. The accurate prediction of their response to...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00892H, Paper
This work is a new proof-of-concept bubble-based gas sensor for a gas chromatography system, which utilizes the unique relationship between the diameters of the produced bubbles with the gas types and mixture ratios as a sensing element.
P. Karásek, Jakub Grym, M. Roth, Josef Planeta and Frantisek Foret
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00843J, Paper
A novel method of etching channels in glass microchips with the most tunable solvent, water, was tested as an alternative to common hydrogen fluoride-containing etchants. The etching properties of water...
Jan Behrens, Sean Langelier, Amgad R. Rezk, Gerhard Lindner, Leslie Y. Yeo and James R. Friend
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00704B, Communication
A versatile, low-power traveling wave SAW microfluidic sorting device using a Schröder diffuser, adopted from its typical use in concert halls to the microscale.
Sha He, Yi Zhang, Pei Wang, Xingzhi Xu, Kui Zhu, Wenying Pan, Wenwen Liu, Kaiyong Cai, Jiashu Sun, Wei Zhang and Xingyu Jiang
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00901K, Paper
A high-throughput, high-efficiency and straightforward microfluidic blotting method for analyzing proteins and nucleic acids.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01143K, Paper
An electrokinetic trapping (EKT)-based nanofluidic preconcentration device with the capability of label-free monitoring of trapped biomolecules through real-time dual-loop electric current measurement was demonstrated. Universal current-voltage (I-V) curves of EKT-based...
Théo Cambier, Thibault Honegger, Valérie Vanneaux, Jean Berthier, David Peyrade, Laurent Blanchoin, Jerome Larghero and Manuel Théry
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00807C, Paper
We designed a very simple 2D array of chambers protected from flow and supplied by a single inlet in order to easily monitor and stain hematopoietic stem cells over long periods of time.
Gisele Elias Nunes-Pauli, Alfredo de la Escosura-Muñiz, Claudio Parolo, Ivan H Bechtold and Arben Merkoçi
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01123F, Paper
We have developed a paper and gold nanoparticle (AuNP)-based lab-in-a-syringe (LIS) for immunosensing of biomarkers. This simple diagnostic device features simultaneous sampling and vertical-flow operation, meaning that unlike typical immunosensors,...
Mayuree Chanasakulniyom, Andrew Glidle and Jonathan M. Cooper
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00774C, Paper
Cell proliferation and migration are fundamental processes in determining cell and tissue behaviour.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC01069H, Paper
Self-sustainable energy sources are essential for a wide array of wireless applications deployed in remote field locations. Due to their self-assembling and self-repairing properties, “biological solar (bio-solar) cells” are recently...
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00987H, Paper
Numbering-up of microchannels was experimentally investigated in a multichannel liquid–liquid micromixer using a model reaction through the blocking strategy.
Huanhuan Feng, Dmitry Ershov, Thomas Krebs, Karin Schroen, Martien A. Cohen Stuart, Jasper van der Gucht and Joris Sprakel
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC00773E, Paper
Combining microcentrifugation, synchronized high-speed imaging and image processing allows direct measurement of coalescence dynamics in thermoresponsive emulsions.

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