Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
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Kumuditha Madushanka Weerakoon Ratnayake, Colleen Erin ONeil, Franklin Uba and Steven A Soper
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01173J, Critical Review
Microfluidics is now moving into a developmental stage where basic discoveries are being transitioned into the commerical sector so that these discoveries can affect, for example, healthcare. Thus, high production...
Md Azahar Ali, kunal Mondal, Yifei Wang, Huawei Jiang, Navreet K Mahal, Michael J Castellano, Ashutosh Sharma and Liang Dong
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01266C, Paper
It is challenging to integrate porous graphene foam (GF) and GF-based nanocomposites into microfluidic channels and even create microfluidic structures within these materials. This is because their irregular interior pore...
Xiangpeng Li, Jessica C. Brooks, Juan Hu, Katarena I. Ford and Christopher J. Easley
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01201A, Paper
A fully automated, 16-channel microfluidic input/output multiplexer (µMUX) has been developed for interfacing to primary cells and to improve understanding of the dynamics of endocrine tissue function. The device utilizes...
Zitian Chen, Peiyu Liao, Fangli Zhang, Mengcheng Jiang, Yusen Zhu and Yanyi Huang
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01305H, Communication
Stable water-in-oil emulsion is essential to digital PCR and many other bioanalytical reactions that employ droplets as microreactors. We developed a novel technology to produce monodisperse emulsion droplets with high...
Minghui Tang, Jacky Fong-Chuen Loo, Yuye Wang, Xuping Zhang, Ho-Chin Kwok, Mamie Hui, Czarina Chi-Hung Leung, Siu-Kai Kong, Guanghui Wang and Ho-Pui Ho
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01169A, Paper
Currently the centrifuge apparatus is primarily an end-point sample processing equipment. The lack of real-time active control has imposed an inherent limitation such that many delicate sample processing steps requiring...
Lynn M. DiMemmo, A. Cameron Varano, Jonathan Haulenbeek, Yanping Liang, Kaya Patel, Madeline J. Dukes, Songyan Zheng, Mario Hubert, Steven P. Piccoli and Deborah F. Kelly
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01160H, Paper
Understanding the properties of protein-based therapeutics is a common goal of biologists and physicians.
Tung-Yi Lin, Truong Do, Patrick Kwon and Peter B. Lillehoj
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01430E, Technical Innovation
We demonstrate a unique approach for fabricating plastic microfluidic devices via hot embossing using 3D printed metal molds.
Yupan Wu, Yukun Ren, Ye Tao, Likai Hou, Qingming Hu and Hongyuan Jiang
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01346E, Paper
Induced-charge electroosmosis (ICEO) phenomena have been attracting considerable attention as a means for pumping and mixing in microfluidic systems with the advantage of simple structures and low-energy consumption.
Amélie Neuville, Louis Renaud, Thi Thuy Luu, Mona Wetrhus Minde, Espen Jettestuen, Jan Ludvig Vinningland, Aksel Hiorth and Dag Kristian Dysthe
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01253A, Paper
In this paper, we propose a simple method to i) embed transparent reactive materials in a microfluidic cell, ii) observe in situ and quantify the dissolution of the material in presence of flowing fluids, using a standard interference microscope.
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00638H, Paper
The neurovascular unit is a complex, interdependent system composed of neurons and neural supporting cells such as astrocytes, as well as cells that comprise the vascular system including endothelial cells,...
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC90128J, Editorial
This Editorial summarizes recent changes at Lab on a Chip and looks forward to further developments in 2017.
Xin Meng, Huachuan Huang, Keding Yan, Xiaolin Tian, Wei Yu, Haoyang Cui, Yan Kong, Liang Xue, Cheng Liu and Shouyu Wang
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01321J, Paper
A smartphone based hand-held quantitative phase microscope using the transport of intensity equation method.
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01049K, Critical Review
Nanoparticles have drawn significant attention in biomedicine due to their unique optical, thermal, magnetic and electrical properties which are highly related to their size and morphologies. Recently, microfluidic systems have...
Michael Chu, Thao Nguyen, Eugene Kuohsi Lee, Julien Laurent Morival and Michelle Khine
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01338D, Technical Innovation
We demonstrate a facile, plasma free, process for fabricating reversibly and permanently sealed microfluidic chips using a PDMS-based adhesive polymer mixture. This method is compatible with current PDMS microfluidics processes,...
Ehsan Samiei, Maria Diaz de Leon Derby, Andre van den Berg and Mina Hoorfar
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00997B, Communication
This paper presents an electrohydrodynamic technique for rapid mixing of droplets in open and closed digital microfluidic (DMF) platforms. Mixing is performed by applying a high frequency AC voltage to...
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01208F, Paper
We developed an efficient and fast method based on a protein microarray integrated with a microfluidic chip for the process of SELEX (systematic evolution of ligands by exponential enrichment).
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01263A, Paper
An integrated device with nanoparticle assay and chaotic micromixing for rapid detection of Hendra virus antibodies.
Masumi Yamada, Wataru Seko, Takuma Yanai, Kasumi Ninomiya and Minoru Seki
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01237J, Paper
Hydrodynamic microfluidic platforms have proven useful and versatile for precisely sorting particles/cells based on their physicochemical properties. In this study, we demonstrate that a simple lattice-shaped microfluidic pattern can work...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01381C, Technical Innovation
We present an image processing and analysis system to facilitate detailed performance analysis of free flow electrophoresis (FFE) chips. It consists of a cost-effective self-built imaging setup and a comprehensive...
Joshua Heinemann, Kai Deng, Jian Gao, Steve C.C. Shih, Paul d Adams, Anup K Singh and Trent R Northen
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01182A, Paper
Biological assays often require expensive reagents and tedious manipulations. These shortcomings can be overcome using digitally operated microfluidic devices that require reduced sample volumes to automate assays. One particular challenge...
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01362G, Technical Innovation
Membrane functionality is crucial in microfluidics for realizing operations such as filtration, separation, concentration, signaling among cells and gradient generation. Currently, common methods often sandwich commercially available membranes in multi-layer...
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01161F, Paper
An optical fiber tunneling mode is used to create 2 excitation/detection points from a single fiber.
A. M. Clark, S. E. Wheeler, C. L. Young, L. Stockdale, J. Shepard Neiman, W. Zhao, D. B. Stolz, R. Venkataramanan, D. Lauffenburger, L. Griffith and A. Wells
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01171C, Paper
Microphysiological systems fitted with hydrogel scaffolds are critical tools in the assessment and development of therapeutic strategies to target dormant metastases.
J. R. Coppeta, M. J. Mescher, B. C. Isenberg, A. J. Spencer, E. S. Kim, A. R. Lever, T. J. Mulhern, R. Prantil-Baun, J. C. Comolli and J. T. Borenstein
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01236A, Paper
A microphysiological systems platform with high precision onboard flow control supports organ model crosstalk for up to 2 weeks.
Josef J. Heiland, Rico Warias, Carsten Lotter, Laura Mauritz, Patrick J. W. Fuchs, Stefan Ohla, Kirsten Zeitler and Detlev Belder
Lab Chip, 2017, Advance Article
DOI: 10.1039/C6LC01217E, Communication
Seamless on-chip integration of a micro reaction unit and an HPLC functionality coupled to MS allows to study stereo selective chemical transformations at the microscale.

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72 citations
This review surveys the leading approaches for sorting cells in microfluidic devices and organizes those technologies by the many physical mechanisms exploited for sorting.
DOI: 10.1039/C4LC01246A
Published: 06 Jan 2015
51 citations
In this paper, a review is carried out of how 3D printing helps to improve the fabrication of microfluidic devices, the 3D printing technologies currently used for fabrication and the future of 3D printing in the field of microfluidics.
DOI: 10.1039/C5LC00685F
Published: 22 Jul 2015
55 citations
We established a microfluidic four-organ-chip for interconnected long-term co-culture of human intestine (1), liver (2), skin (3) and kidney (4) equivalents.
DOI: 10.1039/C5LC00392J
Published: 13 May 2015

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