Journal cover: Lab on a Chip

Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.697 24 Issues per Year Indexed in MEDLINE
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Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00517A, Paper
Kaposi’s sarcoma (KS) is an infectious cancer occurring in immune-compromised patients, caused by Kaposi’s sarcoma herpesvirus (KSHV). Our vision is to simplify the process of KS diagnosis through the creation...
Sophia Lin, Eugene K. Lee, Nancy Nguyen and Michelle Khine
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00528G, Critical Review
This paper reviews progress in micro- and nanofabrication achieved using heat-shrinkable shape memory polymers (SMPs) and the demonstrated applications of the resulting technologies.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00502C, Paper
A portable microfluidic device for the rapid diagnosis of cancer metastatic potential is reported that is capable of separating cells according to their metastatic ability.
Shaohua Ma, Joseph M. Sherwood, Wilhelm T. S. Huck and Stavroula Balabani
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00671B, Paper
The flow topology in moving microdroplets has a significant impact on the behaviour of encapsulated objects and hence on applications of the technology.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00598H, Paper
We present a double-inkjet printing method for the generation of picoliter droplet-in-oil arrays on planar substrates, efficiently addressing droplet evaporation issues without the assistance of a humidifier or glycerol.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00686K, Paper
A plastic microdevice with an embedded filter paper disc was developed for rapid DNA extraction and “in situ” PCR amplification.
Yanbo Xie, Hans de Boer, Ad J Sprenkels, Albert van den Berg and Jan C.T. Eijkel
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00740A, Communication
In this paper, we introduce a microfluidic based self-excited energy conversion system inspired by Kelvin’s water dropper but driven by inertia instead of gravity. Two micro water jets are produced...
Giovanni Marinaro, Angelo Accardo, francesco de angelis, Thomas Dane, Britta Weinhausen, Manfred Burghammer and Christian Riekel
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00750F, Technical Innovation
We developed a new generation of superhydrophobic chips optimized for probing ultrasmall sample quantities by X-ray scattering and fluorescence techniques. The chips are based on thin Si3N4 membranes with a...
Philipp Hahn, Olivier Schwab and Jürg Dual
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00714J, Paper
We investigate how the combination of numerical simulation tools and optimization routines can be used to design micro-devices. Experimental devices that are designed in this way can only provide optimal...
Moez Haque, Kenneth KC Lee, Stephen Ho, Luis A Fernandes and Peter Herman
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00648H, Paper
The lab-on-chip (LOC) platform has presented a powerful opportunity to improve functionalization, parallelization, and miniaturization on planar or multi-level geometries that has not been possible with fiber optic technology. A...
G. Bergström, K. Nilsson, C.-F. Mandenius and N. D. Robinson
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00693C, Communication
Flowing porous gelatin microcarriers pre-seeded with cells into a microfluidic bioreactor is a simple and rapid method for creating 3D cell-culturing environments suitable for toxicity studies.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00363B, Paper
An optofluidic device named the “Insect–Human Hybrid Eye” (IHHE), which combines the architectural merits of both human camera eyes and insect compound eyes, is presented to implement imaging with a large angle of view and adaptive focusing along any direction within the field.
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00700J, Paper
We present pressure tolerant 3D parallel polyimide (PI) film microreactor of up to ~160 bars with direct 3D flow focusing geometry for mass production of PEG-PLGA nanoparticles in a ~10...
Jae Hee Jung, Chao Han, Seung Ah Lee, Jinho Kim and Changhuei Yang
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00790E, Paper
The fabrication of a novel microfluidic system, integrated with a set of laser-controlled microactuators on an ePetri on-chip microscopy platform, is presented in this paper. In the fully integrated microfluidic...
Cheuk-Wing Li, Guodong Yu, Jingyun Jiang, Simon Ming-Yuen Lee, wanqing Helen Yue and Mengsu Yang
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00779D, Paper
We have developed a microfluidic device for continuous separation of small molecules from a protein mixture and demonstrated its practical use in the study of protein-ligand binding that plays a...
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00676C, Paper
From themed collection 2014 Lab on a Chip Emerging Investigators
An antibody barcode microchamber array chip permits the measurement of secreted proteins from pairs of individual tumor and macrophage cells and quantifying paracrine signaling-induced functional changes.
Hyundoo Hwang, Jan Krajniak, Yohei Matsunaga, Guy M. Benian and Hang Lu
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00697F, Communication
This paper describes a novel worm immobilization technique based on optical control of sol–gel transition of thermoreversible Pluronic gel, providing simple, versatile, and biocompatible ways for long-term high-resolution imaging and microinjection of Caenorhabditis elegans.
Florian Lapierre, Maxime Harnois, Yannick Coffinier, Rabah Boukherroub and Vincent Thomy
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00650J, Paper
How to take advantage of superhydrophobic microgrids to address the problem of coupling continuous to digital microfluidic systems? A reconfigurable capillary connection for digital microfluidic devices is presented.
Samad Ahadian, Shukuyo Yamada, Javier Ramon, Kosuke Ino, Hitoshi Shiku, Ali Khademhossein and Tomokazu Matsue
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00479E, Communication
In this manuscript we demonstrate the rapid formation of three-dimensional (3D) embryonic stem cell (ESC) aggregates with controllable sizes and shapes in hydrogels using dielectrophoresis (DEP). The ESCs encapsulated within...
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00609G, Paper
We present a novel method for the determination of aliquot volumes on rotating centrifugal microfluidic platforms using image segmentation.
Chueh-Yu Wu, Oladunni Adeyiga, Jonathan Lin and Dino Di Carlo
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC90067G, Highlight
Electrokinetic concentration on paper – Two-phase in flow concentration on paper – Laser micromachined hybrid open/paper microfluidic chips.
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC90072C, Editorial
From themed collection Lab on a Chip: Insights Issue
George Whitesides, the Chair of the Editorial Board of Lab on a Chip, introduces this year’s “Insights” themed issue.
Tríona M. O’Connell, Damien King, Chandra K Dixit, brendan o'connor, Dermot Walls and Jens Ducree
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00618F, Paper
It is now widely recognised that the earliest changes that occur on a cell when it is stressed or becoming diseased are alterations in its surface glycosylation. Current state-of-the-art technologies...
Lina Wei, Andrew J. Sweeney, Liyuan Sheng, Yu Fang, Mark S. Kindy, Tingfei Xi and Bruce Z. Gao
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00723A, Paper
The single-neuron biochip created by the microfluidics-based laser guided cell-micropatterning system demonstrates high sensitivity in evaluation of the developmental neurotoxicity.
Lyderic Bocquet and Patrick Tabeling
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00325J, Frontier
From themed collection Lab on a Chip 2014 HOT Articles
Cartoon representing the main mechanisms that operate in the nano-, micro- and millifluidic realms. The mechanisms are illustrated by characters whose positions in the spectrum of scales are fixed by the characteristic lengths they are associated with. The fundamental questions of nanofluidics are the following: How do the characteristic scales pertaining to the 1–100 nm range interfere with the system size? Can they combine together to produce new physical effects?

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