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Lab on a Chip

Miniaturisation for chemistry, physics, biology, materials science and bioengineering
Impact Factor 5.586 24 Issues per Year Indexed in Medline
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Alborz Feizi, Yibo Zhang, Alon Greenbaum, Alex Guziak, Michelle Luong, Raymond Yan Lok Chan, Brandon Berg, Haydar Ozkan, Wei Luo, Michael Wu, Yichen Wu and Aydogan Ozcan
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00976J, Paper
Monitoring yeast cell viability and concentration is important in brewing, baking and biofuel production. However, existing methods of measuring viability and concentration are relatively bulky, tedious and expensive. Here we...
Marie-Charlotte Horny, Mathieu Lazerges, Jean-Michel Siaugue, Antoine Pallandre, Daniel Rose, Fethi Bedioui, Claude Deslouis, Anne-Marie Haghiri-Gosnet and Jean Gamby
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00869K, Paper
Here we transposed an ultramicroelectrode (UME) setup into a microfluidic chip configuration for DNA biosensors. Hydrodynamics properties of the fluidic channel microelectrode were screened with [Fe(III)(CN)6]3-/[Fe(II)(CN)6]4- redox couple in cyclic...
Esther Amstad, Michael Chemama, Maximilian Eggersdorfer, Laura Rodriguez Arriaga, Michael Brenner and David A. Weitz
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01075J, Paper
Monodisperse drops with diameters between 20 μm and 200 μm can be used to produce particles or capsules for many applications such as for cosmetics, food, and biotechnology. Drops composed...
Gabriel Amselem, Cyprien Guermonprez, Benoit Drogue, Sébastien Michelin and Charles N Baroud
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00968A, Paper
In spite of the large number of droplet-based microfluidic tools that have appeared in recent years, their penetration into non-specialist labs remains limited to a small number of applications. This...
Javier Lopez Prieto, Hao-Wei Su, Han Wei Hou, Miguel Pinilla Vera, Bruce D Levy, Rebecca M Baron, Jongyoon Han and Joel Voldman
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00940A, Paper
Sepsis is a potentially lethal condition that might benefit from early monitoring of circulating activated leukocytes for faster stratification of severity of illness and improved administration of targeted treatment. Characterization...
Mahtab Hassanpourfard, Ranajay Ghosh, Thomas Thundat and Aloke Kumar
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC01055E, Communication
Bacterial streamer induced clogging regime is characterized by stick-slip fronts and instabilities resulting in formation of water channels.
Liang Hu, Anle Ge, Xixian Wang, Shanshan Wang, Yue Gao, Xiaojun Feng, Wei Du and Bi-Feng Liu
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00948D, Paper
We report an on-demand gas segmented flow generator with high spatiotemporal resolution to analyze neuronal responses of C. elegans to fluctuating gas cues.
Viviane Lutz-Bueno, Jianguo Zhao, Raffaele Mezzenga, Thomas Pfohl, Peter Fischer and Marianne Liebi
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00690F, Paper
The determination of in situ structural information of soft matter under flow is challenging, as it depends on many factors, such as temperature, concentration, confinement, channel geometry, and type of...
Wenming Liu, Chang Tian, Mingming Yan, Lei Zhao, Chao Ma, Tianbao Li, Juan Xu and Jinyi Wang
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00996D, Paper
The construction of a micro-platform capable of microscale control for continuous, dynamic, and high-throughput biomimetic tumor manipulation and analysis plays a significant role in biological and clinical research. Here, we...
Gangadhar Eluru, Albina Lourdes Nirupa Julius and Sai Siva Gorthi
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00935B, Paper
The recent, rapid growth of microfluidic applications has witnessed the emergence of several particle flow focusing techniques for analysis and/or further processing. Majority of flow focusing techniques employ external sheath...
J. Y. Han, O. D. Rahmanian, E. L. Kendall, N. Fleming and D. L. DeVoe
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00862C, Paper
Screw-based micropumps enable precise software-defined flow control with integrated on-chip reagents for portable assays.
L. Zhang, Q. Cai, R. S. Wiederkehr, M. Fauvart, P. Fiorini, B. Majeed, M. Tsukuda, T. Matsuno and T. Stakenborg
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC01046F, Paper
We present a silicon-based integrated microsystem combining a blood lysis chamber, a cross-flow filter, a T-junction mixer, and a microreactor for quantitative polymerase chain reaction. The detection of multiple single nucleotide polymorphisms was demonstrated in the system from human blood.
Lingqian Chang, Lei Li, Junfeng Shi, Yan Sheng, Wu Lu, Daniel Gallego-Perez and L.James Lee
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00840B, Tutorial Review
Electroporation has been one of the most popular non-viral technologies for cell transfection. However, conventional bulk electroporation (BEP) shows significant limitations in efficiency, cell viability and transfection uniformity. Recent advances...
Roozbeh Abedini-Nassab, Daniel Joh, Faris Albarghouthi, Ashutosh Chilkoti, David Martin Murdoch and Benjamin Yellen
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00878J, Paper
The ability to direct and sort individual biological and non-biological particles into spatially addressable locations is fundamentally important to the emerging field of single cell biology. Towards this goal, we...
Jun Zhang, Sheng Yan, Dan Yuan, Qianbin Zhao, Say Hwa Tan, Nam-Trung Nguyen and Weihua Li
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01007E, Paper
Separation of microparticles has found broad applications in biomedicine, industry and clinical diagnosis. In a conventional aqueous ferrofluid, separation of microparticles usually employs a sheath flow or two offset magnets...
Mahiar Max Hamedi, Barış Ünal, Emily Kerr, Ana C Glavan, M. Teresa Fernández-Abedul and George M Whitesides
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00975A, Communication
This communication describes the use of uncoated cellophane (regenerated cellulose films) for the fabrication of microplates, and the use of coated cellophane for the fabrication of open-channel microfluidic devices. The...
Saraí M. Torres Delgado, David J. Kinahan, Fralett Suárez Sandoval, Lourdes Albina Nirupa Julius, Niamh A. Kilcawley, Jens Ducrée and Dario Mager
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00973E, Paper
Wireless power technology for centrifugal microfluidics to bridge the gap between Lab-on-a-Disc and Lab-on-a-Chip by placing the sensors in the frame of reference of the spinning disc.
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00910G, Paper
A crucial yet ill-defined phenomenon involved in the remodeling of vascular networks, including angiogenic sprouting, is flow-mediated endothelial dynamics and phenotype changes. Despite the interstitial flow, a creeping fluid flow...
Ankit Kumar, Shigeng Li, Chieh-Min Cheng and Daeyeon Lee
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01060A, Paper
Phase inversion emulsification (PIE) is a process of generating emulsions by inverting the continuous and dispersed phases of pre-existing emulsions. Although PIE is conventionally performed in batch processes, flowing emulsions...
Floris T. G. van den Brink, Tina Wigger, Liwei Ma, Mathieu Odijk, Wouter Olthuis, Uwe Karst and Albert van den Berg
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00708B, Paper
Reactive xenobiotic metabolites and their adduct formation with biomolecules can be detrimental to human health.
Christian D. Ahrberg, Andreas Manz and Bong Geun Chung
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00984K, Critical Review
Developments of microfluidic-based time/space domain PCR, digital PCR, and isothermal nucleic acid amplification.
Joo Chuan Yeo, Kenry Kenry and Chwee Teck Lim
Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC00926C, Frontier
There has been an intense interest in the development of wearable technologies, arising from increasing demands in the areas of fitness and healthcare. While still at an early stage, incorporating...
Sebastian Haefner, Philipp Frank, Martin Elstner, Johannes Nowak, Stefan Odenbach and Andreas Richter
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00806B, Paper
The utilisation of hydrogels as converters from continuous to discontinuous microfluidics and as storage elements with readout functionality is presented.
María Díaz-González, César Fernández-Sánchez and Antonio Baldi
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00800C, Paper
A new type of electrically controlled and fully integrated wax microvalve is described. The valve is designed for multiple actuation and has a small footprint, fast response and low energy consumption.
Shaurya Prakash and A. T. Conlisk
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC00688D, Tutorial Review
Nanoscale fluid transport through conduits in the 1–100 nm range is termed as nanofluidics.

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42 citations
In this paper, a review is carried out of how 3D printing helps to improve the fabrication of microfluidic devices, the 3D printing technologies currently used for fabrication and the future of 3D printing in the field of microfluidics.
DOI: 10.1039/C5LC00685F
Published: 22 Jul 2015
55 citations
This review surveys the leading approaches for sorting cells in microfluidic devices and organizes those technologies by the many physical mechanisms exploited for sorting.
DOI: 10.1039/C4LC01246A
Published: 06 Jan 2015
42 citations
We established a microfluidic four-organ-chip for interconnected long-term co-culture of human intestine (1), liver (2), skin (3) and kidney (4) equivalents.
DOI: 10.1039/C5LC00392J
Published: 13 May 2015

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