Entropy effects in temperature-regulated nickel-catalyzed regiodivergent alkene hydroalkylation
Density functional theory calculation studies reveal entropy effects in temperature-regulated nickel-catalyzed regiodivergent alkene hydroalkylation.
A convergent paired electrochemical strategy for decarboxylative C(sp2)–C(sp3) bond formation
In this report, we describe a convergent paired electrochemical decarboxylative C(sp2)–C(sp3) cross-coupling reaction that employs readily available alkyl carboxylic acids and C(sp2)–iodides as direct coupling partners.
Nickel/photoredox dual-catalyzed reductive cross-coupling of aryl halides and aldehydes
A photoredox-assisted nickel-catalyzed reductive coupling of aryl halides and aldehydes to afford silyl-protected alcohols is reported. Key to success of this strategy is to identify α-silylamines as efficient organic reductants.
Facile and practical access to chiral benzofused oxa-heterocycles via an asymmetric hydrogenation and intramolecular SNAr cascade
Herein, we report a tandem asymmetric hydrogenation and SNAr reaction, providing valuable six- and five-membered chiral benzofused cyclic ethers with high yields and enantioselectivities (up to 99% yield and up to 99% ee).
Research Article
Pulsed electrolysis: enhancing primary benzylic C(sp3)–H nucleophilic fluorination
Pulsed electrolysis waveforms benefit primary benzylic cation generation and fluorination.
Enantio- and diastereoselective conjugate addition of pyridyl alkyl ketones to enones by Cu(II)-Lewis acid/Brønsted base catalysis
Cu(II) Lewis acid/Brønsted base catalysis was employed to achieve enantio- and diastereoselective conjugate additions of pyridyl alkyl ketones to enones, resulting in the formation of various 1,5-diketones with vicinal stereocenters.
Research Article
Asymmetric copper-catalyzed alkynylallylic dimethylamination
A reliable protocol for asymmetric Cu-catalyzed alkynylallylic dimethylamination is described with the discovery of tetramethyldiaminomethane as a new, stable and convenient surrogate of the dimethylamine nucleophile.
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