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Themed collection Recent HOT articles

47 items
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The dangers of hazards

Concerns about the quality and reproducibility of scientific papers have emphasised the uncertainty of observations in the biological sciences.

Graphical abstract: The dangers of hazards
From the themed collection: Recent Review Articles
Review Article

Cytotoxicological pathways induced after nanoparticle exposure: studies of oxidative stress at the ‘nano–bio’ interface

This review focuses on the most common toxicological pathways induced by nanoparticle exposure.

Graphical abstract: Cytotoxicological pathways induced after nanoparticle exposure: studies of oxidative stress at the ‘nano–bio’ interface
From the themed collection: Recent Review Articles
Review Article

Toxic mechanisms of microcystins in mammals

This review discusses mechanisms of toxicity, particularly those observed in liver tissue, mediated by microcystins (MCs) produced by cyanobacteria.

Graphical abstract: Toxic mechanisms of microcystins in mammals
From the themed collection: Recent Review Articles
Review Article

Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8)

Recent updates on various molecular and pathophysiological aspects of the zinc transporter ZIP8 (SLC39A8).

Graphical abstract: Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8)
From the themed collection: Recent Review Articles
Review Article

The effects of T-2 toxin on the prevalence and development of Kashin–Beck disease in China: a meta-analysis and systematic review

The interpretation of high T-2 toxin detection rate and amount in endemic areas on Kashin–Beck disease prevalence and development.

Graphical abstract: The effects of T-2 toxin on the prevalence and development of Kashin–Beck disease in China: a meta-analysis and systematic review
From the themed collection: Recent Review Articles
Review Article

Key mechanisms involved in ionizing radiation-induced systemic effects. A current review

Organisms respond to exogenous threats and insults by a potent inflammatory and immune response, aimed at preserving tissue integrity and restoring tissue homeostasis and function.

Graphical abstract: Key mechanisms involved in ionizing radiation-induced systemic effects. A current review
From the themed collection: Recent Review Articles
Communication

Cysteine-induced hormesis effect of silver nanoparticles

The toxicity of silver nanoparticles (AgNPs) is widely exploited, but their hormesis effect has, so far, received little attention.

Graphical abstract: Cysteine-induced hormesis effect of silver nanoparticles
From the themed collection: Recent HOT articles
Communication

A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication

A novel hybrid able to protect organophosphate-inhibited AChE as well as to reactivate it.

Graphical abstract: A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication
From the themed collection: Recent HOT articles
Paper

Metabolomics for the early detection of cisplatin-induced nephrotoxicity

Metabolomics is a useful tool for discovering biomarkers to predict the side effects of cancer therapy.

Graphical abstract: Metabolomics for the early detection of cisplatin-induced nephrotoxicity
From the themed collection: Recent HOT articles
Paper

In silico prediction of pesticide aquatic toxicity with chemical category approaches

Herein, six machine learning methods combined with nine fingerprints were used to predict aquatic toxicity of pesticides.

Graphical abstract: In silico prediction of pesticide aquatic toxicity with chemical category approaches
From the themed collection: Recent HOT articles
Paper

Regulating temperature and relative humidity in air–liquid interface in vitro systems eliminates cytotoxicity resulting from control air exposures

Modifications to a VITROCELL exposure system were required to mitigate cytotoxicity caused by the absence of temperature and humidity control.

Graphical abstract: Regulating temperature and relative humidity in air–liquid interface in vitro systems eliminates cytotoxicity resulting from control air exposures
From the themed collection: Recent HOT articles
Paper

Mucor circinelloides: efficiency of bioremediation response to heavy metal pollution

Mucor circinelloides, selected from mine tailings for heavy metal bioremediation, was characterized at the genetic level by internal transcribed spacer (ITS) analysis.

Graphical abstract: Mucor circinelloides: efficiency of bioremediation response to heavy metal pollution
From the themed collection: Recent HOT articles
Paper

Coal combustion related fine particulate matter (PM2.5) induces toxicity in Caenorhabditis elegans by dysregulating microRNA expression

We employed an in vivo assay system of Caenorhabditis elegans to determine if and which microRNAs (miRNAs) were dysregulated upon exposure to coal combustion related fine particulate matter (PM2.5) by profiling the miRNAs using SOLiD sequencing.

Graphical abstract: Coal combustion related fine particulate matter (PM2.5) induces toxicity in Caenorhabditis elegans by dysregulating microRNA expression
From the themed collection: Recent HOT articles
Paper

Mitochondria and MAPK cascades modulate endosulfan-induced germline apoptosis in Caenorhabditis elegans

Our data provide the direct in vivo evidence to indicate the molecular signalling mechanism of endosulfan-induced apoptosis.

Graphical abstract: Mitochondria and MAPK cascades modulate endosulfan-induced germline apoptosis in Caenorhabditis elegans
From the themed collection: Recent HOT articles
Paper

The muscarinic effect of anhydroecgonine methyl ester, a crack cocaine pyrolysis product, impairs melatonin synthesis in the rat pineal gland

AEME impaired melatonin synthesis both in vivo and in vitro and this effect seems to be mediated by muscarinic receptors and [Ca2+]i elevation.

Graphical abstract: The muscarinic effect of anhydroecgonine methyl ester, a crack cocaine pyrolysis product, impairs melatonin synthesis in the rat pineal gland
From the themed collection: Recent HOT articles
Paper

Assessment of cadmium-induced nephrotoxicity using a kidney-on-a-chip device

Cadmium (Cd) is a common environmental pollutant.

Graphical abstract: Assessment of cadmium-induced nephrotoxicity using a kidney-on-a-chip device
From the themed collection: Recent HOT articles
Paper

The mutagenic mechanism of oxygenated alkylhydrazones occurs through alkyl radicals and alkyldiazonium ions

Hydrazone hydroperoxides were formed by autoxidation and their mutagenicity was derived from the alkyldiazonium ion and the radical species.

Graphical abstract: The mutagenic mechanism of oxygenated alkylhydrazones occurs through alkyl radicals and alkyldiazonium ions
From the themed collection: Recent HOT articles
Paper

Circulating miRNAs and their target genes associated with arsenism caused by coal-burning

The results confirm that the circulating levels of miR-21, miR-145, miR-155, and miR-191 are increased in patients with arsenism caused by coal-burning and these miRNAs inhibit the target genes of pathways related to immune inflammation, oxidative stress, and DNA damage repair.

Graphical abstract: Circulating miRNAs and their target genes associated with arsenism caused by coal-burning
From the themed collection: Recent HOT articles
Paper

Cytotoxicity of T-2 and modified T-2 toxins: induction of JAK/STAT pathway in RAW264.7 cells by hepatopancreas and muscle extracts of shrimp fed with T-2 toxin

T-2 and modified T-2s are cytotoxic. Activation of the JAK/STAT pathway in RAW264.7 cells by T-2 was greater in hepatopancreas and muscle extracts from Litopenaeus vannamei.

Graphical abstract: Cytotoxicity of T-2 and modified T-2 toxins: induction of JAK/STAT pathway in RAW264.7 cells by hepatopancreas and muscle extracts of shrimp fed with T-2 toxin
From the themed collection: Recent HOT articles
Paper

Evaluation of the DNA damaging potential of indigenous health hazardous quartz nanoparticles on the cultured lung cells

Quartz nanoparticles (QNPs) cause various diseases in the biological systems and are thus considered as hazardous materials; however, their properties are important in a wide range of biological and pharmaceutical entities.

Graphical abstract: Evaluation of the DNA damaging potential of indigenous health hazardous quartz nanoparticles on the cultured lung cells
From the themed collection: Recent HOT articles
Paper

Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation

Because air pollution is a complex mixture of pollutants, understanding the health risks requires an evaluation of their combined effects rather than predictions based on the single chemicals alone.

Graphical abstract: Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation
From the themed collection: Recent HOT articles
Paper

Pyrazinamide-induced hepatotoxicity and gender differences in rats as revealed by a 1H NMR based metabolomics approach

Pyrazinamide disturbed the metabolic profiles of rats with gender difference, with regard to metabolic pathways related to its hepatotoxicity.

Graphical abstract: Pyrazinamide-induced hepatotoxicity and gender differences in rats as revealed by a 1H NMR based metabolomics approach
From the themed collection: Recent HOT articles
Paper

Assessment of synergistic thyroid disrupting effects of a mixture of EDCs in ovariectomized rats using factorial analysis and dose addition

Endocrine disrupting chemicals (EDCs) have been implicated in a broad spectrum of health problems related to reproduction, thyroid function, neurodevelopment, and metabolism.

Graphical abstract: Assessment of synergistic thyroid disrupting effects of a mixture of EDCs in ovariectomized rats using factorial analysis and dose addition
From the themed collection: Recent HOT articles
Paper

Signals involved in the effects of bisphenol A (BPA) on proliferation and motility of Leydig cells: a comparative proteomic analysis

Recent studies indicated that bisphenol A (BPA) can disrupt spermatogenesis and then cause male infertility.

Graphical abstract: Signals involved in the effects of bisphenol A (BPA) on proliferation and motility of Leydig cells: a comparative proteomic analysis
From the themed collection: Recent HOT articles
Paper

MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO2, NO2 and PM2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway

The role of ambient air pollution is considered to be important in the development of chronic obstructive pulmonary disease (COPD), and pulmonary hypertension (PH) is a common clinical manifestation of COPD.

Graphical abstract: MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO2, NO2 and PM2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway
From the themed collection: Recent HOT articles
Paper

Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats

Quinine is an antimalarial drug; however, its use is limited by its narrow therapeutic index and elevated side effects.

Graphical abstract: Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats
From the themed collection: Recent HOT articles
Paper

Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil

The evaluation of mercury (Hg) toxicity in agricultural soil is of great concern because its bioavailability and bioaccumulation in organisms through the food chain can have adverse effects on human health.

Graphical abstract: Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil
From the themed collection: Recent HOT articles
Paper

Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study

Many in vivo studies have revealed that the cytotoxic potential of gold nanoparticles results in controversial conclusions.

Graphical abstract: Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study
From the themed collection: Recent HOT articles
Paper

Role of cytochrome P450s in the male reproductive toxicity of 1-bromopropane

Cytochrome P450 contributes to male reproductive toxicity of 1-bromopropane.

Graphical abstract: Role of cytochrome P450s in the male reproductive toxicity of 1-bromopropane
From the themed collection: Recent HOT articles
Paper

Effects of prenatal and lactation nicotine exposure on glucose homeostasis, lipogenesis and lipid metabolic profiles in mothers and offspring

Perinatal nicotine exposure affects mothers’ and pups’ glucose homeostasis, lipogenesis and lipid metabolic profiles. The effects on pups include the direct roles of nicotine and indirect roles of maternal alterations.

Graphical abstract: Effects of prenatal and lactation nicotine exposure on glucose homeostasis, lipogenesis and lipid metabolic profiles in mothers and offspring
From the themed collection: Recent HOT articles
Paper

Combined toxicity of Fe3O4 nanoparticles and cadmium chloride in mice

Co-exposure to nano-Fe3O4 and CdCl2 attenuated CdCl2-induced damage in mice through mutually competitive inhibition of Fe and Cd uptake.

Graphical abstract: Combined toxicity of Fe3O4 nanoparticles and cadmium chloride in mice
From the themed collection: Recent HOT articles
Paper

Comparative oxidative stress elicited by nanosilver in stable HSPA1A promoter-driven luciferase reporter HepG2 and A549 cells

HSPA1A promoter-driven luciferase reporter gene assay provides a novel tool for predictive screening of the oxidative stress elicited by nanosilver.

Graphical abstract: Comparative oxidative stress elicited by nanosilver in stable HSPA1A promoter-driven luciferase reporter HepG2 and A549 cells
From the themed collection: Recent HOT articles
Paper

Long-term exposure of K562 cells to benzene metabolites inhibited erythroid differentiation and elevated methylation in erythroid specific genes

We demonstrate that long-term and low-dose exposure to benzene metabolites inhibits hemin-induced erythroid differentiation of K562 cells, in which DNA methylation plays a role through depressing erythroid specific genes.

Graphical abstract: Long-term exposure of K562 cells to benzene metabolites inhibited erythroid differentiation and elevated methylation in erythroid specific genes
From the themed collection: Recent HOT articles
Paper

Detection of the carcinogenic properties of synthetic and natural dyes using positron annihilation lifetime spectrometry

Positron annihilation lifetime spectrometry was used to detect the carcinogenic properties of a range of synthetic and natural dyes used in the food and drug industries.

Graphical abstract: Detection of the carcinogenic properties of synthetic and natural dyes using positron annihilation lifetime spectrometry
From the themed collection: Recent HOT articles
Open Access Paper

Characterization of a functional C3A liver spheroid model

We have developed a method for creating C3A liver spheroids and demonstrated cellular polarisation, zonation as well as increased liver-specific functionality and more predictive toxicological response compared to standard 2D liver models.

Graphical abstract: Characterization of a functional C3A liver spheroid model
From the themed collection: Recent HOT articles
Paper

QSAR modeling for predicting reproductive toxicity of chemicals in rats for regulatory purposes

The figure shows the prediction performance of (a) DTF-QSAR and (b) DTB-QSAR models for pLOAEL (rat) in training and test data.

Graphical abstract: QSAR modeling for predicting reproductive toxicity of chemicals in rats for regulatory purposes
From the themed collection: Recent HOT articles
Paper

Multi-tissue metabolic responses of goldfish (Carassius auratus) exposed to glyphosate-based herbicide

Glyphosate disturbed the metabolomic profiles of goldfish, with regard to metabolic pathways that were related with its toxicity.

Graphical abstract: Multi-tissue metabolic responses of goldfish (Carassius auratus) exposed to glyphosate-based herbicide
From the themed collection: Recent HOT articles
Open Access Paper

Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons

Our data represent the first demonstration that oxy-PAHs can be potent inhibitors of CYP1 expression and function.

Graphical abstract: Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons
From the themed collection: Recent HOT articles
Paper

In silico prediction of the developmental toxicity of diverse organic chemicals in rodents for regulatory purposes

The figure shows performance of the local and global QSAR and ISC-QSAAR models in predicting the developmental toxicity potential of chemicals in rodents.

Graphical abstract: In silico prediction of the developmental toxicity of diverse organic chemicals in rodents for regulatory purposes
From the themed collection: Recent HOT articles
Paper

Formaldehyde-induced toxicity in the nasal epithelia of workers of a plastic laminate plant

The generation of M1dG adducts can constitute an additional molecular mechanism for formaldehyde-induced nasal carcinogenesis.

Graphical abstract: Formaldehyde-induced toxicity in the nasal epithelia of workers of a plastic laminate plant
From the themed collection: Recent HOT articles
Paper

eIF3 regulates migration, invasion and apoptosis in cadmium transformed 16HBE cells and is a novel biomarker of cadmium exposure in a rat model and in workers

Translation (eukaryotic) initiation factor 3 (eIF3 or TIF3) has been found to be a proto-oncogene in cadmium (Cd) response both in vitro and vivo, but whether eIF3 may serve as a biomarker of Cd exposure is still unclear.

Graphical abstract: eIF3 regulates migration, invasion and apoptosis in cadmium transformed 16HBE cells and is a novel biomarker of cadmium exposure in a rat model and in workers
From the themed collection: Recent HOT articles
Paper

Prenatal caffeine exposure-induced adrenal developmental abnormality in male offspring rats and its possible intrauterine programming mechanisms

Glucocorticoid (GC) is a major factor for fetal tissue maturation and fate decision after birth.

Graphical abstract: Prenatal caffeine exposure-induced adrenal developmental abnormality in male offspring rats and its possible intrauterine programming mechanisms
From the themed collection: Recent HOT articles
Paper

Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells

Benzo(a)pyrene (B[a]P) is a common environmental and foodborne pollutant which has been identified as a Group I carcinogen. And the global metabolic effects of long-term B[a]P exposure at low dosage were investigated.

Graphical abstract: Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells
From the themed collection: Recent HOT articles
Paper

HIF-2α, acting via miR-191, is involved in angiogenesis and metastasis of arsenite-transformed HBE cells

Arsenic is a well established human carcinogen that causes diseases of the lung.

Graphical abstract: HIF-2α, acting via miR-191, is involved in angiogenesis and metastasis of arsenite-transformed HBE cells
From the themed collection: Recent HOT articles
Paper

Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways

The development of therapeutic approaches combining efficacy and safety represents an important goal in intestinal inflammation research.

Graphical abstract: Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways
From the themed collection: Recent HOT articles
Paper

Cytotoxic effects of aspartame on human cervical carcinoma cells

In the present study we determined the effects of aspartame at various concentrations on cell viability, morphology, ROS level and DNA in human cervical carcinoma cells over different exposure periods.

Graphical abstract: Cytotoxic effects of aspartame on human cervical carcinoma cells
From the themed collection: Recent HOT articles
Paper

Mechanistic understanding of molecular initiating events (MIEs) using NMR spectroscopy

The effectiveness of NMR spectroscopy is demonstrated for the characterisation of Molecular Initiating Events in TT21C-aligned approaches to risk assessments.

Graphical abstract: Mechanistic understanding of molecular initiating events (MIEs) using NMR spectroscopy
From the themed collection: Recent HOT articles
47 items

About this collection

This themed collection features articles published in Toxicology Research marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.

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